KAIST research team has succeeded in developing the technology that allows high capacity protein storage.
Professor Omar M. Yaghi (Graduate School of EEWS) and his research team succeeded in developing the core technology that enables the storage of various types of proteins by developing a metal organic structure. The result of their research was published in the May edition of Science magazine.
The newly developed technology can store various types and sizes of proteins. This property is expected to pave way to: 1) development of high capacity, high integration drugs 2) development of virus separation compounds 3) selective removal of protein causing negative reactions in the body 4) permanent preservation of rare polymeric proteins, among other expectations.
In addition it becomes possible to selectively remove and preserve all the body’s cells including stem cells which will aid the development of cures for incurable diseases and increase life expectancy and medical technology in general.
Conventional metal-organic structure used 7 Angstrom large small single molecules and therefore could not be used in the storage of large molecules or proteins. Its usability was proven only as potential high capacity gas storage structure. In addition the internal structure of the metal organic structure is cross linked which made it even more difficult to store large proteins within the structure.
Professor Yaghi’s team used molecular structure over 5nm in length in the development of the metal-organic structure to solve the problem associated with size of structure. The ordered structure of the structure’s pore was observed for the first time using Transmission Electron Microscope.
The new structure enables the ordered storage of large proteins and was able to store vitamin and proteins like myoglobin at high capacity for the first time in the world.