Department+of+Chemical
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Prof. Sang-Yup Lee Founding Member of Board of Editors of mBop
Prof. Sang-Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed as one of the founding board of editors of the mBio which will be launched next year, the university reported on Friday (Nov. 20).
mBio is the American Society for Microbiology"s first all-online, open access journal which will be launched in next May. According to the mBio website, the journal"s scope "will reflect the enormity of the microbial world, a highly interconnected biosphere where microbes interact with living and non-living matter to produce outcomes that range from symbiosis to pathogenesis, energy acquisition and conversion, climate change, geologic change, food and drug production, and even animal behavioral change."
Prof. Lee, LG Chem Chair Professor, is currently the Dean of the College of Life Science and Bioengineering and director of the Center for Systems and Synthetic Biotechnology. He received his B.S. in Chemical Engineering from Seoul National Univeristy in Korea and his M.S. and Ph.D. in Chemical Engineering from Northwestern University.
As of September 2009, he has published 298 journal papers and has more than 440 patents either registered or applied. Also, he has published 47 books/book chapters, "Systems Biology and Biotechnology of Escherichia Coli" being the latest.
His research interests are systems biology and biotechnology, industrial biotechnology, metabolic engineering, synthetic biology and nanobiotechnology. In particular, he has pioneered systems metabolic engineering, which integrates systems biology with metabolic engineering, for the development of micropoganisms possessing superior properties for industrial applications.
2009.11.20 View 12965 -
Prof. Woo's Team Discovers Eco-Friendly Solid-Oxide Fuel Cell System
A KAIST research team led by Prof. Seong-Ihl Woo of the Department of Chemical & Biomolecular Engineering has found a method to use glycerol, a byproduct from the production of biodiesel, as fuel for solid oxide fuel cells (SOFC), university authorities said on Tuesday (Oct. 27).
The research finding shows that glycerol can be an environmentally sustainable fuel when it is used for operating SOFCs with internal reforming, instead of hydrogen and methane. The finding was published in the Oct. 14, 2009 online edition of ChemSusChem, a sister journal of Angewandte Chemie, the world"s leading chemistry journal.
Biodiesel is an attractive alternative energy source because of its low sulfur content and demand is growing worldwide as oil price soars. Bio-derived glycerol will not contribute to the greenhouse effect and has the potential to contribute to reducing global warming.
Currently, glycereol is used as a raw material in the cosmetic, pharmacy, food, and tobacco industries. However, its supply exceeds its demand as the volume of biodiesel production increases. The production of 1 ton of biodiesel produces 0.1 ton of glycerol. Many researchers have investigated various routes for the consumption of surplus glycerol.
The research is expected to contribute to sustainable growth by reducing the emissions of carbon dioxide and reusing generated carbon dioxide for the production of biomass. The new method enables manufacturers to use glycerol as a fuel for operating SOFC.
2009.10.28 View 14027 -
Prof. Lee"s Team Pioneers Biotechnological Production of Chemical Using Renewable Materials
A research team led by Prof. Sang-Yup Lee of the Bio and Brain Engineering Department at KAIST has succeeded in engineering the bacterium E. coli to produce the industrial chemical putrescine, university authorities said on Monday (Aug. 31).
Putrescine, a four carbon chain diamine, is an important platform chemical with a wide range of applications for the pharmaceutical, agrochemical and chemical industries. It is currently used to synthesize nylon-4,6, a widely used engineering plastic.
The research result, published in the Biotechnology and Bioengineering journal, proviDrdes a renewable alternative to the traditional process using fossil fuels.
Currently the production of putrescine on an industrial scale relies on chemical synthesis, which requires non-renewable petrochemicals and expensive catalyst systems. This process is highly toxic and flammable with potentially severe repercussions for both the environment and human health.
"For the first time we have developed a metabolically engineered E. coli strain that efficiently produces putrescine," said Professor Lee. "The development of a bio-refinery for chemicals and materials is very important in a world where dependency on fossil fuels is an increasing concern."
The team developed a strain of E.coli capable of producing putrescine through metabolic engineering. This is where a cell"s metabolic and regulatory networks are enhanced in order to increase production of a needed material.
First the team weakened or deleted competing metabolic pathways within the E. coli strain before deleting pathways which cause putrescine degradation. They also amplified the crucial enzyme Spec C, which converts the chemical ornithine into putrescine. Finally the putrescine exporter, which allows excretion of intracellularly made putrescine, was engineered while a global regulator was engineered to further increase the concentration of putrescine. The final result of this process was an engineered E.coli strain which produced 24.2 g of putrescine per litre.
However, as it was believed that putrescine is toxic to microorganisms the team had to study putrescine tolerance in E.coli before it could be engineered to overproduce the chemical to the levels needed for industrial production.
The results revealed that E. coli can tolerate at least 0.5 M of putrescine, which is tenfold higher than the usual concentration in the cell. This level of tolerance was an important surprise as it means that E. coli can be engineered to overproduce putrescine to industrially competitive levels.
"The previously expected toxicity of putrescine may explain why its microbial production has been overlooked," said Lee. "Now a metabolically engineered E. coli strain has been developed which is capable of efficiently producing putrescine using renewable methods to an industrial level. This metabolic engineering framework should be useful for developing metabolically engineered microorganisms for the efficient production of other chemicals from renewable resources," he added.
2009.09.01 View 15031 -
KAIST College of Life Sciences and Bioengineering Signs MOU with Harvard
KAIST’s College of Life Sciences and Bioengineering recently signed a memorandum of understanding (MOU) with Harvard University’s Center for Brain Science on July 20, which will allow for joint research and exchange in researchers between the two institutions.
Headed by Director Kenneth Blum, Harvard’s Center for Brain Science leads the world in brain-related research. The new MOU will allow for research cooperation, exchanges of professors, researchers, and students, joint usage of infrastructure and research materials, and finally, sharing of research assignments.
The Dean of the College of Life Sciences and Bioengineering Sang Yup Lee, who concerted efforts to form the MOU said, “This agreement will bring together two of the world’s leading brain-related research teams, and I hope that combining their expertise will bring great advances in brain science and engineering.
KAIST’s College of Life Science and Bioengineering, which is known for its creative interdisciplinary research, is producing exemplary research results in the field of brain science from its Biological Sciences and Bio and Brain Engineering departments.
In addition to cooperation with Harvard, KAIST has also formed partnerships with Emory University, Japan’s RIKEN Brain Institute, and Germany’s Max Planck Institute. Not only does it have a worldwide network pertaining to brain research, but KAIST has also engaged in cooperative research with prominent domestic institutions such as, Asan Medical Center, the Korea Research Institute of Bioscience and Biotechnology, the Korea Research Institute of Standards and Science, and the SK Corporation. Through these connections, KAIST has managed to lead in mutually cooperative brain interdisciplinary research.
2009.08.10 View 17153 -
KAIST Professor Sang-Yup Lee Chair of International Metabolic Engineering Conference Due Next Year
KAIST distinguished professor Sang-Yup Lee was named to chair the 17th Metabolic Engineering Conference which will convene on Jeju Island, Korea, next year, under the theme of "Metabolic Engineering for Green Growth." It was decided at the 16th Biochemical Engineering Conference held in Burlington, Vermont, on July 5-9.
Metabolic Engineering Conference in 2010 will not only involve presentations and discussions about metabolic engineering, but will inaugurate the “World Council on Industrial Biotechnology,” which will bring together global corporations and the world’s experts in industrial biochemical engineering, according to sources at KAIST.
A KAIST official commented, “The fact that the Metabolic Engineering Conference is to be held here [in Korea] proves that Korea is being acknowledged as a key player in this field.”
As the world faces the depletion of fossil fuels and environmental pollution, nations are showing increasing interest in industrial biochemical alternatives, such as microscopic organisms or new chemicals, to solve their problems. In addition, efficient production of biochemical materials and bio-fuels using microbes is deemed vital for the future.
“The Korean government has become a model to other countries thanks to its leadership in carrying out the ‘Green Growth’ policy,” Professor Sang-Yup Lee said. He stated that KAIST is recognized for its research in advanced biochemical material and fuel production methods.
“Green Growth,” a concept first developed by ESCAP, the UN agency working for social and economic cooperation in Asia and the Pacific, aims to achieve sustainable economic growth without destroying the environment.
Ref. Department of Biochemical Engineering, Metabolic and BioMolecular Engineering Lab, KAIST
2009.07.17 View 14078 -
KAIST Research Team Unveils Method to Fabricate Photonic Janus Balls
A research team led by Prof. Seung-Man Yang of the Department of Chemical and Biomolecular Engineering has found a method to fabricate photonic Janus balls with isotropic structural colors.
The finding draws attention since the newly-fabricated photonic balls may prove useful pigments for the realization of e-paper or flexible electronic displays.
The breakthrough was published in the Nov. 3 edition of the science journal "Advanced Materials." The Nov. 6 issue of "Nature" also featured it as one of the research highlights under the title of "Future Pixels."
Prof. Yang"s research team found that tiny marbles, black on one side and colored on the other, can be made by "curing" suspensions of silica particles with an ultraviolet lamp. When an electric field is applied, the marbles line up so that the black sides all face upwards, which suggests they may prove useful pigments for flexible electronic displays.
The researchers suspended a flow of carbon-black particles mixed with silica and a transparent or colored silica flow in a resin that polymerizes under ultraviolet light. They then passed the mixture through a tiny see-through tube. The light solidified the silica and resin as balls with differently colored regions, each about 200 micrometers in diameter.
Over the last decades, the development of industrial platforms to artificially fabricate structural color pigments has been a pressing issue in the research areas of materials science and optics. Prof. Yang, who is also the director of the National Creative Research Initiative Center for Integrated Optofluidic Systems, has led the researches focused on fabrication of functional nano-materials through the process of assembling nano-building blocks into designed patterns.
The "complementary hybridization of optical and fluidic devices for integrated optofluidic systems" research was supported by a grant from the Creative Research Initiative Program of the Ministry of Education, Science & Technology.
2008.11.12 View 15017 -
Prof. Sang-Yup Lee Receives Merck Award for Metabolic Engineering
Prof. Sang-Yup Lee of KAIST"s Department of Chemical and Biomolecular Engineering has been chosen as the winner of the 2008 Merck Award for Metabol;ic Engineering established by the world"s leading pharmaceutical and chemical company Merck, KAIST officials said Tuesday, Sept. 16.
The Distinguished Professor of KAIST and LG Chem Chair Professor will receive the award on Sept. 18 during the 7th Metabolic Engineering convention now underway at Puerto Vallarta, Mexico. Prof. Lee will give a commemorative lecture, titled "Systems Metabolic Engineering for Chemicals," at the biannual academic conference. Prof. Lee is the fourth to win the coveted award which is given to the world"s top expert in metabolic engineering with outstanding achievements in the field.
Prof. Lee, 44, who graduated from Seoul National University and earned his master"s and doctoral degrees in chemical engineering from Northwestern University of the United States, is now the dean of the College of Life Science and Bioengineering, KAIST. Since 1994, he has served as the head of the Metabolic and Biomolecular Engineering National Research Laboratory, director of the BioProcess Engineering Center, Director of the Bioinformatics Research Center and Co-Director of the Institute for the BioCentury in KAIST.
Prof. Lee said he was receiving the Merck award "as a representative of KAIST graduates, students and researchers" who have worked with him at the Metabolic Engineering Lab. He added he was happy to see the outcome of bioengineering development projects supported by the Ministry of Education, Science and Technology over the past years was now being recognized by the world"s leading scientific society with the Merck Award.
Metabolic engineering, the art of optimizing genetic and regulatory processes within cells to increase the cell"s production of a certain substance, develops technologies that hold the key to the resolution of the world"s energy, food and environmental problems. The indispensible technology in bioengineering can be applied to the production of biomass to obtain alternative fuel.
Prof. Lee has actively participated in publishing such academic periodicals as Biotechnology Journal (as chief editor), Biotechnology and Bioengineering (deputy editor) and Metabolic Engineering (a member of the editorial committee).
2008.09.17 View 15928 -
Prof. Lee Appointed to Advisory Board of the U.S. Joint BioEnergy Institute
Prof. Sang-Yup Lee of the Department of Chemical and Biomolecular Engineering, KAIST, has been appointed as a member of the scientific advisory board of the Joint BioEnergy Institute under the wing of the U.S. Department of Energy, university authorities said on Monday (Aug. 4).
The Joint BioEnergy Institute (JBEI) is a scientific partnership in the San Francisco Bay area, California, led by Lawrence Berkeley National Laboratory (Berkeley Lab). Its partner organizations include the Sandia National Laboratories, the University of California in Berkeley, UC Davis, the Carnegie Institution for Science and the Lawrence Livermore National Laboratory.
JBEI
2008.08.07 View 13320 -
Storing Stably Hydrogen Atoms in Icy Materials Discovered
KAIST, Aug. 8, 2008 -- A KAIST research team led by Prof. Huen Lee of the Department of Chemical & Biomolecular Engineering has discovered that icy organic hydrates, which contain small cages that can trap guest molecules, can be used to create and trap hydrogen atoms at higher temperatures.
The properties and reactions of single hydrogen atoms are of great scientific interest because of their inherent quantum mechanical behavior; experimentally, they can be generated and stabilized at very low temperatures (4 K) by high-energy irradiation of solid molecular hydrogen.
The finding was reported in the journal of American Chemical Society and featured in the "Editor"s Choice" in the July 11 issue of Science as a recent research highlight.
Hydrogen is a clean and sustainable form of energy that can be used in mobile and stationary applications. Hydrogen has the potential to solve several major challenges today: depletion of fossil fuels, poor air quality, and green house gas emissions.
However, the trapping of hydrogen atoms in crystalline solid matrix has never been attempted mainly because of experimental difficulties in identifying the generated hydrogen atoms with either spectroscopic or microscopic technique.
"To overcome the barriers and limitations of the existing storage approaches, we have continuously attempted to find the new hydrogen storage media such as icy powders and other related inclusion compounds," said Prof. Lee
The discovery follows the breakthrough concept Prof. Lee"s research team proposed in Nature in 2005 to use pure ice to capture and store hydrogen molecules. At moderate temperature and pressure conditions small guest molecules are entrapped in pure ice powders to form the mixed icy hydrate materials.
"Stable existence of single hydrogen molecule/radical in icy crystalline matrices may offer significant advantages in exploring hydrogen as a quantum medium because icy hydrogen hydrates can be formed at milder conditions when compared with pure solid hydrogen, which requires the ultra low temperature of 4.2 K," said Prof. Lee.
The novel design and synthesis of ionic and radicalized icy hydrates are expected to open a new field for inclusion chemistry and ice-based science and technology. Specifically, the fact that hydrogen atoms can be stably stored in icy materials might provide versatile and practical applications to energy devices including fuel cells, ice-induced reactions, and novel energy storage process, according to the KAIST professor.
2008.08.07 View 14245 -
KAIST Professors Article Featured as Cover Thesis of Biotechnology Journal
An article authored by a research team of Prof. Sang-yup Lee at the Department of Chemical and Biomolecular Engineering and Dr. Jin-Hwan Park at the KAIST Institute for the BioCentury has been featured as the cover thesis of the August 2008 issue of Trends in Biotechnology.
The paper, titled "General strategy for strain improvement by means of systems metabolic engineering," focuses on the application of systems biology for the development of strains and illustrates future prospects. Trends in Biotechnology, published by Cell Press, is one of the most prestigious review journals in the field.
Jin-Hwan Park, the primary author of the research thesis, said that the KAIST team"s research work was expected to provide substantial help to researchers involved in biotechnology industry.
The strategy has been established on the basis of the experiences gained in the actual microbial production process using the systems biology methods which his research team has recently worked on, Prof. Park said.
2008.07.24 View 16237
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KAIST, GS Caltex Jointly Develop New Bacteria to Produce Biobutanol
KAIST and GS Caltex, Korea"s second-largest refiner, have jointly developed a new strain of bacteria to produce biobutanol, which is regarded as a promising next-generation biofuel, KAIST authorities said on Monday (June 2).
A research team led by Prof. Sang-Yup Lee of the Chemical and Biomolecular Engineering Department and researchers of GS Caltex succeeded in developing an improved strain of bacteria which enables to produce a large amount of biobutanol in the process of fermenting biomass. The research team has applied for international patent for the new technology.
Biomass refers to living and recently dead biological material that can be used as fuel or for industrial production. It usually refers to plant matter grown for use as biofuel, but it also includes plant or animal matter used for production of fibers, chemicals or heat.
In the 1970s and 1980s when scientists began researching the possibilities of alternative fuels, bacteria were used in the process of fermenting biomass. This ABE (acetone, butanol, ethanol) fermentation process yields butanol, acetone, and ethanol in a ratio of 6:3:1, respectively. Acetone produced in this process is not usable.
The newly developed technology to produce biobutanol has an advantage of lowering production cost by eliminating the process to separate acetone from butanol. This has been made possible by improving the bacteria used for the fermentation in metabolic engineering terms, and producing butanol and ethanol only in a ratio of 6:1, while curbing the generation of acetone.
In comparison with bioethanol, also a biofuel mixture which is currently under widespread use in some countries, butanol is more easily transported with gasoline and diesel through pipelines because of its lower tendency to separate from the fuel when contaminated with water. Butanol is also less corrosive than ethanol, another reason its transport through pipeline is preferable.
Global interest in full utilization of biomass and development of other alternative energy including biobutanol has deepened in recent years, as crude oil prices have skyrocketed to record levels and climate changes resulting from the excessive use of fossil fuel have been causing various problems around the world.
2008.06.04 View 13349 -
International Science Journal Spotlights Korean Biotechnology
Biotechnology Journal published by German-based Wiley-VCH, one of the world"s major scientific and technical publishers, devoted its entire special edition for May to biotechnology in Korea.
The monthly journal"s special issue was planned by KAIST Professor Sang-Yup Lee of the Chemical and Biomolecular Engineering Department who is one of the journal"s two editors-in-chief.
The special issue outlines the current status and future prospect of biotechnology in Korea, and presents five review papers and eight original papers by leading Korean biotech researchers to showcase recent developments in Korean biotechnology. Among these papers, a review by Dr. Byung-Hwan Hyeon and his colleagues describes in detail the Korean biotechnology strategies represented by "Bio-Vision 2016," and another by Dr. Ji-Hyun Kim and his collaborators presents recent progress in microbial genome projects in Korea.
In the editorial of the journal, Prof. Lee said, "Heavy industry and IT industry have been the two drivers of Korean economic growth. Korea is now considering biotechnology as its next generation growth engine."
Underscoring the growing importance of fusion research, he mentioned that integration of biotechnology with information technology and nanotechnology is advancing rapidly in Korea. Another special edition of Biotechnology Journal focusing on these exciting biotech developments in Korea is planned for the future.
2008.05.20 View 14999