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Professor Otfried Cheong Named as Distinguished Scientist by ACM
Professor Otfried Cheong (Schwarzkopf) of the School of Computing was named as a Distinguished Scientist of 2016 by the Association for Computing Machinery (ACM).
The ACM recognized 45 Distinguished Members in the category of Distinguished Scientist, Educator, and Engineer for their individual contributions to the field of computing. Professor Cheong is the sole recipient from a Korean institution. The recipients were selected among the top 10 percent of ACM members with at least 15 years of professional experience and five years of continuous professional membership.
He is known as one of the authors of the widely used computational geometry textbook Computational Geometry: Algorithms and Applications and as the developer of Ipe, a vector graphics editor. Professor Cheong joined KAIST in 2005, after earning his doctorate from the Free University of Berlin in 1992. He previously taught at Ultrecht University, Pohang University of Science and Technology, Hong Kong University of Science and Technology, and the Eindhoven University of Technology.
2017.04.17 View 6667 -
Nuclease-Resistant Hybrid Nanoflowers
An eco-friendly method to synthesize DNA-copper nanoflowers with high load efficiencies, low cytotoxicity, and strong resistance against nucleases has been developed by Professor Hyun Gyu Park in the Department of Chemical and Biomolecular Engineering and his collaborators.
The research team successfully formed a flower-shaped nanostructure in an eco-friendly condition by using interactions between copper ions and DNA containing amide and amine groups. The resulting nanoflowers exhibit high DNA loading capacities in addition to low cytotoxicity.
Flower-shaped nanocrystals called nanoflowers have gained attention for their distinct features of high surface roughness and high surface area to volume ratios. The nanoflowers have been used in many areas including catalysis, electronics, and analytical chemistry.
Of late, research breakthroughs were made in the generation of hybrid inorganic-organic nanoflowers containing various enzymes as organic components. The hybridization with inorganic materials greatly enhanced enzymatic activity, stability, and durability compared to the corresponding free enzymes.
Generally, the formation of protein nanocrystals requires high heat treatment so it has limitations for achieving the high loading capacities of intact DNA.
The research team addressed the issue, focusing on the fact that nucleic acids with well-defined structures and selective recognition properties also contain amide and amine groups in their nucleobases. They proved that flower-like structures could be formed by using nucleic acids as a synthetic template, which paved the way to synthesize the hybrid nanoflowers containing DNA as an organic component in an eco-friendly condition.
The team also confirmed that this synthetic method can be universally applied to any DNA sequences containing amide and amine groups. They said their approach is quite unique considering that the majority of previous works focused on the utilization of DNA as a linker to assemble the nanomaterials. They said the method has several advantageous features. First, the ‘green’ synthetic procedure doesn’t involve any toxic chemicals, and shows low cytotoxicity and strong resistance against nucleases. Second, the obtained nanoflowers exhibit exceptionally high DNA loading capacities.
Above all, such superior features of hybrid nanoflowers enabled the sensitive detection of various molecules including phenol, hydrogen peroxide, and glucose. DNA-copper nanoflowers showed even higher peroxidase activity than those of protein-copper nanoflowers, which may be due to the larger surface area of the flower- shaped structures, creating a greater chance for applying them in the field of sensing of detection of hydrogen peroxide.
The research team expects that their research will create diverse applications in many areas including biosensors and will be further applied into therapeutic applications.
Professor Park said, “The inorganic component in the hybrid nanoflowers not only exhibits low cytotoxicity, but also protects the encapsulated DNA from being cleaved by endonuclease enzymes. Using this feature, the nanostructure will be applied into developing gene therapeutic carriers.”
This research was co-led by Professor Moon Il Kim at Gachon University and KAIST graduate Ki Soo Park, currently a professor at Konkuk University, is the first author. The research was featured as the front cover article of the Journal of Materials Chemistry B on March 28, Issue 12, published by the Royal Society of Chemistry.
The research was funded by the Mid-Career Researcher Support Program of the National Research Foundation of Korea and the Global Frontier Project of the Ministry of Science, ICT & Future Planning.
(Figure: (A) Schematic illustration of the formation of nuclease-resistant DNA–inorganic nanoflowers. (B) SEM images showing time-dependent growth of DNA-nanoflowers. The concentration of A-rich ssDNA (Table S1, ESI†) was 0.25 mM.)
2017.04.14 View 8265 -
KOOC Provides New Insights on Open Online Courses
KAIST’s free open online courses with innovative education modules are gaining a great deal of public attention. To reflect the increasing demand, KAIST will expand the number of courses offered via the KAIST Massive Open Online Course (KOOC) system from the five courses currently available to 12 courses from April 17. More courses will reportedly be offered in the second semester.
According to KOOC service team, more than 15,000 people enrolled in KOOCs since its opening last May. They said the ever increasing number of enrollment reflects the wide public interest to experience the high standard of the curriculum taught by KAIST faculty. The service team reported that they felt the need to diversify the curriculum in response to increasing enrollment. The new courses will span from the introduction to chemical engineering, to game theory, to writing research papers.
They also said that KAIST’s innovative education modules focusing on self-driven learning have drawn wide attention from the public. In the KOOCs, enrolled students can proactively engage in online Q&A discussions with professors. Currently, the KOOCs are only run in Korean, but the Introduction to Data Structure and Algorithms will be run in English with Korean subtitles.
The subjects of 2017 KOOCs are as follow:
-Introduction to Operations Research
-Light, Color, and Life
-Introduction to Chemical Engineering
-Introduction to the Application of AI/DM Technology I & II
-How to Write Research Papers
-Game Theory
-Optimization Techniques for Computer Vision
-Introduction to Data Structures and Algorithms I & II
-Sensor Engineering-Principles of Sensing Technology and Sensor Design
For more on the KOOCs, please visit http://kooc.kaist.ac.kr
2017.04.14 View 3348 -
Improving Traffic Safety with a Crowdsourced Traffic Violation Reporting App
KAIST researchers revealed that crowdsourced traffic violation reporting with smartphone-based continuous video capturing can dramatically change the current practice of policing activities on the road and will significantly improve traffic safety.
Professor Uichin Lee of the Department of Industrial and Systems Engineering and the Graduate School of Knowledge Service Engineering at KAIST and his research team designed and evaluated Mobile Roadwatch, a mobile app that helps citizen record traffic violation with their smartphones and report the recorded videos to the police.
This app supports continuous video recording just like onboard vehicle dashboard cameras. Mobile Roadwatch allows drivers to safely capture traffic violations by simply touching a smartphone screen while driving. The captured videos are automatically tagged with contextual information such as location and time. This information will be used as important evidence for the police to ticket the violators. All of the captured videos can be conveniently reviewed, allowing users to decide which events to report to the police.
The team conducted a two-week field study to understand how drivers use Mobile Roadwatch. They found that the drivers tended to capture all traffic risks regardless of the level of their involvement and the seriousness of the traffic risks. However, when it came to actual reporting, they tended to report only serious traffic violations, which could have led to car accidents, such as traffic signal violations and illegal U-turns. After receiving feedback about their reports from the police, drivers typically felt very good about their contributions to traffic safety.
At the same time, some drivers felt pleased to know that the offenders received tickets since they thought these offenders deserved to be ticketed. While participating in the Mobile Roadwatch campaign, drivers reported that they tried to drive as safely as possible and abide by traffic laws. This was because they wanted to be as fair as possible so that they could capture others’ violations without feeling guilty. They were also afraid that other drivers might capture their violations.
Professor Lee said, “Our study participants answered that Mobile Roadwatch served as a very useful tool for reporting traffic violations, and they were highly satisfied with its features. Beyond simple reporting, our tool can be extended to support online communities, which help people actively discuss various local safety issues and work with the police and local authorities to solve these safety issues.”
Korea and India were the early adaptors supporting video-based reporting of traffic violations to the police. In recent years, the number of reports has dramatically increased. For example, Korea’s ‘Looking for a Witness’ (released in April 2015) received more than half million reported violations as of November 2016. In the US, authorities started tapping into smartphone recordings by releasing video-based reporting apps such as ICE Blackbox and Mobile Justice. Professor Lee said that the existing services cannot be used while driving, because none of the existing services support continuous video recording and safe event capturing behind the wheel.
Professor Lee’s team has been incorporating advanced computer vision techniques into Mobile Roadwatch for automatically capturing traffic violations and safety risks, including potholes and obstacles. The researchers will present their results in May at the ACM CHI Conference on Human Factors in Computing Systems (CHI 2017) in Denver, CO, USA. Their research was supported by the KAIST-KUSTAR fund.
(Caption: A driver is trying to capture an event by touching a screen. The Mobile Radwatch supports continuous video recording and safe event captureing behind the wheel.)
2017.04.10 View 9768 -
Scholarship in Memory of Professor Shin Endowed by His Family
Professor Joong-Hoon Shin of the Graduate School of Nanoscience and Technology was touted as a genius young scientist who would take the lead in nanoscience technology. After earning degrees from Harvard and the Caltech, he was appointed at KAIST at age 27. He was the youngest professor ever appointed in Korea.
Professor Shin’s outstanding research in the field of semiconductor nano-optics led him to be named as the ‘Scientist of the Year’ for three consecutive years from 2004 by the most prestigious scientist and technology organizations including the Korean Academy Science and Technology, the National Research Foundation of Korea, and the Korean government. However, a fatal car accident last September on the way home from a seminar in Gangwon Province took his life and a promising scholar’s research was left unfinished. He was 47 years old.
Mrs. Young-Eun Hong, the widow of the late Professor Shin, made a 100 million KRW gift to KAIST to establish the ‘Joong-Hoon Shin Scholarship’ on April 7. The scholarship will provide financial assistance to outstanding students of physics and nanoscience.
At the donation ceremony attended by President Sung-Chul Shin, Professor Shin’s colleagues and students, and family members, Mrs. Hong said, “My family would like to help young students achieve their dreams on behalf of my husband. I hope students will remember my husband’s passion and dedication toward his studies for a long time. He was a very hard worker.”
Working at KAIST, Professor Shin made significant achievements in field of semiconductor nano-optics, specializing in silicon photonics and silicon nanocrystal structures. In particular, his research team gained attention reproducing the structure of ‘Morpho butterfly’ wings, which produce the same colors from various angles, using external light as a light source without extra power. Their research led to the creation of original technology dubbed the biomimetics reflective display and was published in Nature in 2012.
Professor Shin’s legacy still endures. In February, a research team under Professor Shin-Hyun Kim of the Department of Chemical and Biomolecular Engineering includingthe late Professor Shin’s doctoral student Seung Yeol Lee, posthumously dedicated their research published on Advanced Materials to Professor Shin. ( click )
KAIST President Sung-Chul Shin, who is also a physicist, said “His passing is a great loss to the whole scientific and technology community, at home and abroad. But Joong-Hoon Shin scholarship will enable the growth and ensure the strength of nanoscience and its education at KAIST. We will uphold Professor Shin’s legacy by doing our best to make KAIST a world-leading university which can create global value.”
Mrs. Hong said she will continue her husband’s academic legacy at his alma maters, Harvard and the Caltech, where he earned his BS in physics and his Ph.D. in applied physics respectively. She said she will start fundraising to establish the Joong-Hoon Shin Scholarship at Harvard and Caltech from July.
(Mrs. Hong poses with President Sung-Chul Shin after donating 100 million KRW for establishing 'Joong-Hoon Shin Scholarship' in memory of her husband on April 7.)
2017.04.10 View 6798 -
Professor Won Do Heo Receives 'Scientist of the Month Award'
Professor Won Do Heo of the Department of Biological Sciences was selected as the “Scientist of the Month” for April 2017 by the Ministry of Science, ICT and Future Planning and the National Research Foundation of Korea.
Professor Heo was recognized for his suggestion of a new biological research method developing various optogenetics technology which controls cell function by using light. He developed the technology using lasers or LED light, without the need for surgery or drug administration, to identify the cause of diseases related to calcium ions such as Alzheimer’s disease and cancer.
The general technique used in optogenetics, that control cells in the body with light, is the simple activation and deactivation of neurons.
Professor Heo developed a calcium ion channel activation technique (OptoSTIM1) to activate calcium ions in the body using light. He also succeeded in increasing calcium concentrations with light to enhance the memory capacity of mice two-fold.
Using this technology, the desired amount and residing time of calcium ion influx can be controlled by changing light intensity and exposure periods, enabling the function of a single cell or various cells in animal tissue to be controlled remotely.
The experimental results showed that calcium ion influx can be activated in cells that are affected by calcium ions, such as normal cells, cancer cells, and human embryonic stem cells. By controlling calcium concentrations with light, it is possible to control biological phenomena, such as cellular growth, neurotransmitter transmission, muscle contraction, and hormone control.
Professor Heo said, “Until now, it was standard to use optogenetics to activate neurons using channelrhodopsin. The development of this new optogenetic technique using calcium ion channel activation can be applied to various biological studies, as well as become an essential research technique in neurobiology.
The “Scientist of the Month Award” is given every month to one researcher who made significant contributions to the advancement of science and technology with their outstanding research achievement. The awardee will receive prize money of ten million won.
2017.04.07 View 7271 -
Crowdsourcing-Based Global Indoor Positioning System
Research team of Professor Dong-Soo Han of the School of Computing Intelligent Service Lab at KAIST developed a system for providing global indoor localization using Wi-Fi signals. The technology uses numerous smartphones to collect fingerprints of location data and label them automatically, significantly reducing the cost of constructing an indoor localization system while maintaining high accuracy.
The method can be used in any building in the world, provided the floor plan is available and there are Wi-Fi fingerprints to collect. To accurately collect and label the location information of the Wi-Fi fingerprints, the research team analyzed indoor space utilization. This led to technology that classified indoor spaces into places used for stationary tasks (resting spaces) and spaces used to reach said places (transient spaces), and utilized separate algorithms to optimally and automatically collect location labelling data.
Years ago, the team implemented a way to automatically label resting space locations from signals collected in various contexts such as homes, shops, and offices via the users’ home or office address information. The latest method allows for the automatic labelling of transient space locations such as hallways, lobbies, and stairs using unsupervised learning, without any additional location information. Testing in KAIST’s N5 building and the 7th floor of N1 building manifested the technology is capable of accuracy up to three or four meters given enough training data. The accuracy level is comparable to technology using manually-labeled location information.
Google, Microsoft, and other multinational corporations collected tens of thousands of floor plans for their indoor localization projects. Indoor radio map construction was also attempted by the firms but proved more difficult. As a result, existing indoor localization services were often plagued by inaccuracies. In Korea, COEX, Lotte World Tower, and other landmarks provide comparatively accurate indoor localization, but most buildings suffer from the lack of radio maps, preventing indoor localization services.
Professor Han said, “This technology allows the easy deployment of highly accurate indoor localization systems in any building in the world. In the near future, most indoor spaces will be able to provide localization services, just like outdoor spaces.” He further added that smartphone-collected Wi-Fi fingerprints have been unutilized and often discarded, but now they should be treated as invaluable resources, which create a new big data field of Wi-Fi fingerprints. This new indoor navigation technology is likely to be valuable to Google, Apple, or other global firms providing indoor positioning services globally. The technology will also be valuable for helping domestic firms provide positioning services.
Professor Han added that “the new global indoor localization system deployment technology will be added to KAILOS, KAIST’s indoor localization system.” KAILOS was released in 2014 as KAIST’s open platform for indoor localization service, allowing anyone in the world to add floor plans to KAILOS, and collect the building’s Wi-Fi fingerprints for a universal indoor localization service. As localization accuracy improves in indoor environments, despite the absence of GPS signals, applications such as location-based SNS, location-based IoT, and location-based O2O are expected to take off, leading to various improvements in convenience and safety. Integrated indoor-outdoor navigation services are also visible on the horizon, fusing vehicular navigation technology with indoor navigation.
Professor Han’s research was published in IEEE Transactions on Mobile Computing (TMC) in November in 2016.
For more, please visit http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7349230http://ieeexplore.ieee.org/document/7805133/
2017.04.06 View 8624 -
Improving Silver Nanowires for FTCEs with Flash Light Interactions
Flexible transparent conducting electrodes (FTCEs) are an essential element of flexible optoelectronics for next-generation wearable displays, augmented reality (AR), and the Internet of Things (IoTs). Silver nanowires (Ag NWs) have received a great deal of attention as future FTCEs due to their great flexibility, material stability, and large-scale productivity. Despite these advantages, Ag NWs have drawbacks such as high wire-to-wire contact resistance and poor adhesion to substrates, resulting in severe power consumption and the delamination of FTCEs.
A research team led by Professor Keon Jae Lee of the Materials Science and Engineering Department at KAIST and Dr. Hong-Jin Park from BSP Inc., has developed high-performance Ag NWs (sheet resistance ~ 5 Ω/sq, transmittance 90 % at λ = 550 nm) with strong adhesion on plastic (interfacial energy of 30.7 J∙m-2) using flash light-material interactions.
The broad ultraviolet (UV) spectrum of a flash light enables the localized heating at the junctions of nanowires (NWs), which results in the fast and complete welding of Ag NWs. Consequently, the Ag NWs demonstrate six times higher conductivity than that of the pristine NWs. In addition, the near-infrared (NIR) of the flash lamp melted the interface between the Ag NWs and a polyethylene terephthalate (PET) substrate, dramatically enhancing the adhesion force of the Ag NWs to the PET by 310 %.
Professor Lee said, “Light interaction with nanomaterials is an important field for future flexible electronics since it can overcome thermal limit of plastics, and we are currently expanding our research into light-inorganic interactions.”
Meanwhile, BSP Inc., a laser manufacturing company and a collaborator of this work, has launched new flash lamp equipment for flexible applications based on the Professor Lee’s research.
The results of this work entitled “Flash-Induced Self-Limited Plasmonic Welding of Ag NW Network for Transparent Flexible Energy Harvester (DOI: 10.1002/adma.201603473)” were published in the February 2, 2017 issue of Advanced Materials as the cover article.
Professor Lee also contributed an invited review in the same journal of the April 3, 2017 online issue, “Laser-Material Interactions for Flexible Applications (DOI:10.1002/adma.201606586),” overviewing the recent advances in light interactions with flexible nanomaterials.
References
[1] Advanced Materials, February 2, 2017, Flash-Induced Self-Limited Plasmonic Welding of Ag NW network for Transparent Flexible Energy Harvester http://onlinelibrary.wiley.com/doi/10.1002/adma.201603473/epdf
[2] Advanced Materials, April 3, 2017, Laser-Material Interactions for Flexible Applications
http://onlinelibrary.wiley.com/doi/10.1002/adma.201606586/abstract
For further inquiries on research:
keonlee@kaist.ac.kr (Keon Jae Lee), hjpark@bsptech.co.kr (Hong-Jin Park)
Picture 1: Artistic Rendtition of Light Interaction with Nanomaterials
(This image shows flash-induced plasmonic interactions with nanowires to improve silver nanowires (Ag NWs).)
Picture 2: Ag NW/PET Film
(This picture shows the Ag NWs on a polyethylene terephthalate (PET) film after the flash-induced plasmonic thermal process.)
2017.04.05 View 9492 -
Coin Karaoke on Campus
Singing at the top of your lungs can sometimes be a healthy outlet for relieving your stress. The Undergraduate Student Association at KAIST offers just that. They created coin karaoke kiosks on campus where students can visit and sing their favorite songs across a variety of music genres.
The KAI Coin Karaoke opened near the amphitheater, which consists of five kiosks for one to three people, two booths for six people, and one self-service coin machine. The operation hours are from 12 pm to 2 am, and it costs only 500 KRW for two songs.
“I often enjoy going to a karaoke for singing whenever I feel down and need to let things out,” said Tae-Sik Im, a junior undergraduate of the School of Computing. “Now, I don’t have to leave campus to find a place to sing. It’s much more convenient and safer.”
Many students even squeeze in time to stop by the karaoke during their breaks in between classes and enjoy belting out songs. Afterwards, students confessed, they are in a better mood for class.“We received a great deal of support from our students during our trial period in February. The facility officially opened on March 20 and anyone can go there and find some time to refresh themselves,” explained Young-Duck Cho, president of KAIST Undergraduate Student Association. He said all proceeds will go to students’ welfare fund. There are three rules to abide by for karaoke users though: no alcohol, no smoking, and no haning out.
(Photo caption:Students sing out at the newly opened KAI Coin Karaoke on the campus.)
2017.03.28 View 3668 -
Expanding the Genetic Code of Mus Musculus
Professor Hee-Sung Park of the Department of Chemistry, who garnered attention for his novel strategy of installing authentic post-translational modifications into recombinant proteins, expanded his research portfolio to another level. Professor Park’s team was the first to report the generation of a mouse strain with an expanded genetic code, allowing site-specific incorporation of unnatural amino acids.
Professor Park published the research on the new chemical biology method for achieving selective chemical modifications in proteins in Science last September. The research team, this time in collaboration with Professor Chan Bae Park of the Department of Physiology at the Ajou University School of Medicine, demonstrated temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein as a model protein. This research was published in the online edition of Nature Communications on February 21.
This approach enables the rapid onset of position-specific acetylation of a target protein at any developmental stage, facilitating temporal and spatial control of protein acetylation in various organs of the transgenic mouse. Such temporal and spatial control of protein acetylation will be of prime importance for investigating many essential biological processes and human diseases at the tissue and organism level.
Almost all human proteins, the products of about 25,000 genes, are known to undergo various post-translational modifications during and after synthesis. Post-translation modifications regulate the function of cellular proteins, playing a key role in many essential processes such as delivering signals and body growth. However, the unusual protein modifications, aroused from genetic and/or environmental factors, trigger severe diseases including cancer, dementia, and diabetes.
The team inserted transgenes into the mouse genome to allocate the site-specific addition of unnatural amino acids. The researchers inserted a modified version of lysine into the house mice, which allowed for the control of the acetylation. They used recombinant green fluorescent proteins from transgenic house mice as models for control of the acetylation.
The team was also able to regulate the acetylation of specific temporal and spatial frames in the mice, restraining the abnormality in proteins to certain organs such as the liver and kidneys. The research team said the strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organisms for human physiology and disease. Professor Park said, “This method can be easily extended to generate a wide range of custom-made transgenic mouse strains for further investigating diverse proteins of interest.” He added, “This method can be further extended to generate a wide range of custom-made transgenic mouse strains, opening a new paradigm for investigating anti-cancer and cerebral disease treatments.
This work was supported by grants from KAIST Systems Healthcare and the Medicinal Bioconvergence Research Center and the Intelligent Synthetic Biology Center of the Global Frontier Project funded by the Ministry of Science, ICT & Future Planning and the Ministry of Food and Drug Safety.
(Figure:Temporal and spatial control of in vivo protein acetylation)
(a) Temporal expression of acetylated GFPuv in the AcK-GFPamber mouse. The expression of GFPuv in skeletal muscle, liver, and lung tissues was detected only in the AcK-injected mouse. Scale bar, 200 µm. (b) Western blotting of anti-FLAG-immunoprecipitated proteins from tissues of the AcK-GFPamber mouse. Acetylated GFPuv was produced after AcK injection. (c) Spatial expression of acetylated GFPuv in the AcK-GFPamber mouse. Acetylated GFPuv was observed only in skeletal muscle when AcK was directly delivered to the tissues. Sacle bar, 200 µm.
2017.03.27 View 8424 -
ANSYS Korea Donates Engineering Simulation Software
ANSYS Korea made an in-kind donation of engineering simulation software, Multiphysics Campus Solution, to KAIST on March 24. ANSYS Korea donated 10,000 copies for education and 1,000 copies for research valued at about 4 billion KRW (about 200 billion KRW commercially).
The ANSYS software will benefit the engineering simulation work in nine departments and 60 labs for three years, including the departments of mechanical engineering, aerospace engineering, electrical engineering, civil and environmental engineering, nuclear and quantum engineering, chemical and bimolecular engineering, bio and brain engineering, materials science and engineering, and the Cho Chun Shik Graduate School of Green Transportation.
ANSYS is a global engineering simulation company. It provides ANSYS CAE (Computer Aided Engineering) software products in various industries in the world as well as various support, training, and consulting services. Deemed an exemplary model of university-industry R&D collaboration especially in the Industry 4.0 era, their donation will help create the best engineering education environment possible at KAIST.
ANSYS's multi-physics campus solution is a comprehensive software suite that spans the entire range of physics, providing access to virtually any field of engineering simulation that a design process requires. It expands the fields of fluids, structures, electromagnetics, and semiconductors. Undergraduates use it to learn physics principles and gain hands-on, real-world experience that can lead to a deeper understanding of engineering concepts. Postgraduate researchers apply simulation tools to solve complex engineering problems and produce data for their theses.
"Engineering simulations are playing a stronger role in science and engineering. ANSYS software will help our undergraduates and our researchers learn the principles of physics and deepen their understanding of engineering concepts. We hope this will serve as an instrumental tool for multidisciplinary studies, critical to fostering our students," said President Sung-Chul Shin.
ANSYS Korea CEO Yong-Won Cho added, "We sincerely hope our software will help KAIST students and researchers experience the best engineering education and achieve significant research results."
(Photo caption: President Shin (left) poses with ANSYS Korea CEO Yong-Won Cho at the donation ceremony on March 24 at KAIST)
2017.03.24 View 7504 -
First Mutations in Human Life Discovered
The earliest mutations of human life have been observed by research team led by the Wellcome Trust Sanger Institute and their collaborators. Analyzing genomes from adult cells, the scientists could look back in time to reveal how each embryo developed.
Research team of the Sanger Institute including Professor Young Seok Ju of the Graduate School of Medical Science and Engineering at KAIST published an article of “Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo” in Nature on March 22.
The study shows that from the two-cell stage of the human embryo, one of these cells becomes more dominant than the other and leads to a higher proportion of the adult body.
A longstanding question for researchers has been what happens in the very early human development as this has proved impossible to study directly. Now, researchers have analyzed the whole genome sequences of blood samples (collected from 279 individuals with breast cancer) and discovered 163 mutations that occurred very early in the embryonic development of those people.
Once identified, the researchers used mutations from the first, second and third divisions of the fertilized egg to calculate which proportion of adult cells resulted from each of the first two cells in the embryo. They found that these first two cells contribute differently to the whole body. One cell gives rise to about 70 percent of the adult body tissues, whereas the other cell has a more minor contribution, leading to about 30percent of the tissues. This skewed contribution continues for some cells in the second and third generation too.
Originally pinpointed in normal blood cells from cancer patients, the researchers then looked for these mutations in cancer samples that had been surgically removed from the patients during treatment. Unlike normal tissues composed of multiple somatic cell clones, a cancer develops from one mutant cell. Therefore, each proposed embryonic mutation should either be present in all of the cancer cells in a tumor, or none of them. This proved to be the case, and by using these cancer samples, the researchers were able to validate that the mutations had originated during early development.
Dr. Young Seok Ju, first author from the Wellcome Trust Sanger Institute and KAIST, said: "This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack. There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis."
Dr. Inigo Martincorena, from the Sanger Institute, said: "Having identified the mutations, we were able to use statistical analysis to better understand cell dynamics during embryo development. We determined the relative contribution of the first embryonic cells to the adult blood cell pool and found one dominant cell - that led to 70 percent of the blood cells - and one minor cell. We also sequenced normal lymph and breast cells, and the results suggested that the dominant cell also contributes to these other tissues at a similar level. This opens an unprecedented window into the earliest stages of human development."
During this study, the researchers were also able to measure the rate of mutation in early human development for the first time, up to three generations of cell division. Previous researchers had estimated one mutation per cell division, but this study measured three mutations for each cell doubling, in every daughter cell.
Mutations during the development of the embryo occur by two processes - known as mutational signatures 1 and 5. These mutations are fairly randomly distributed through the genome, and the vast majority of them will not affect the developing embryo. However, a mutation that occurs in an important gene can lead to disease such as developmental disorders.
Professor Sir Mike Stratton, lead author on the paper and Director of the Sanger Institute, said: "This is a significant step forward in widening the range of biological insights that can be extracted using genome sequences and mutations. Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better. This is just one early insight into human development, with hopefully many more to come in the future."
(Figure 1. Detection of somatic mutations acquired in early human embryogenesis )
(Figure 2. Unequal contributions of early embryonic cells to adult somatic tissues )
2017.03.23 View 7186