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Gout Diagnostic Strip Using a Single Teardrop
A novel diagnostic strip for gout patients using a single teardrop has been announced by KAIST research team. This technology analyzes biological molecules in tears for a non-invasive diagnosis, significantly reducing the time and expense previously required for a diagnosis.
The research team under Professor Ki-Hun Jeong of the Department of Bio and Brain Engineering succeeded in developing an affordable and elaborate gout diagnostic strip by depositing metal nanoparticles on paper. This technology can not only be used in diagnostic medicine and drug testing, but also in various other areas such as field diagnoses that require prompt and accurate detection of a certain substance.
Gout induces pain in joints due to needle-shaped uric acid crystal build up. In general, therapeutic treatments exist to administer pain relief, stimulate uric acid discharge, and uric acid depressant. Such treatments work for temporary relief, but there have significant limitations. Thus, patients are required to regularly check uric acid concentrations, as well as control their diets. Therefore, simpler ways to measure uric acid would greatly benefit gout control and its prevention in a more affordable and convenient manner.
Existing gout diagnostic techniques include measuring uric acid concentrations from blood samples or observing uric acid crystals from joint synovial fluid under a microscope. These existing methods are invasive and time consuming. To overcome their limitations, the research team uniformly deposited gold nanoislands with nanoplasnomics properties on the surface of paper that can easily collect tears.
Nanoplasnomics techniques collect light on the surface of a metal nanostructure, and can be applied to disease and health diagnostic indicators as well as for genetic material detection. Further, metals such as gold absorb stronger light when it is irradiated, and thus can maximize light concentration on board surfaces while maintaining the properties of paper. The developed metal nanostructure production technology allows the flexible manufacturing of nanostructures on a large surface, which in turn allows flexible control of light concentrations.
The research team grafted surface-enhanced Raman spectroscopy on paper diagnostic strips to allow uric acid concentration measurements in teardrops without additional indicators. The measured concentration in teardrops can be compared to blood uric acid concentrations for diagnosing gout.
Professor Jeong explained, “Based on these research results, our strip will make it possible to conduct low-cost, no indicator, supersensitive biological molecule analysis and fast field diagnosis using tears.” He continued, “Tears, as well as various other bodily fluids, can be used to contribute to disease diagnosis and physiological functional research.”
Ph.D. candidate Moonseong Park participated in the research as the first author of the paper that was published in the online edition of ACS Nano on December 14, 2016. Park said, “The strip will allow fast and simple field diagnosis, and can be produced on a large scale using the existing semiconductor process.”
(Figure 1. Optical image of paper gout diagnostic strip covered with gold)
(Figure 2. Scanning delectron microscopic image of paper gout diagnostic strip)
(Figure 3. Scanning electron microscope image of cellulos fiber coated with gold nanoislands)
(Figure 4. Gout diagnosis using tears)
2017.04.27 View 8095 -
Professor Lee Recognized by the KMS as Best Paper Awardee
Professor Ji Oon Lee of the Department of Mathematical Sciences was selected as the 2017 Best Paper Awardee by the Korean Mathematical Society. The award will be presented during the KMS spring meeting on April 29. Dr. Lee is being honored for proving a necessary and sufficient condition for the Tracy-Wisdom law of Wigner matrices. In a paper titled ‘A Necessary and Sufficient Condition for Edge Universality of Wigner Matrices,’ he proposed a solution for one of the many unanswered problems in the field of random matrix theory that have existed for decades. The paper, co-authored with Professor Jun Yin at the University of Wisconsin – Madison, was published in the Duke Mathematical Journal in 2014. Professor Lee joined KAIST in 2010 after finishing his Ph.D. at Harvard University. He was named a ‘POSCI Science Fellow’ and received the ‘Young Scientist Award’ from the KMS in 2014.
2017.04.27 View 7599 -
Seeking a New Economic and Industrial Paradigm
The School of Humanities & Social Science will offer the open lecture course titled ‘Seeking a New Economic and Industrial Paradigm’ from May11 to June 7. This is part of a quarterly lecture series run by the school and open to the public.
The open lecture is designed to provide opportunities for the public to identify future challenges and opportunities for Korea’s economy and industry. Experts in macroeconomics, finance, and global collaboration will provide glimpses of new directions for each sector as well as megatrends of emerging technologies on the heels of the 4th Industrial Revolution.
Jin Hyuk Yoo from the Bank of Korea will speak on the ‘Outlook and Challenges of the Korean Economy.’ He will identify the current economic situation and explain how to build on sustainable long-term economic growth in the opening course.
Won-Bin Lee of the Korea Institute for Industrial Economics & Trade will present on the ‘New Industrial Policy in the Era of the Fourth Industrial Revolution.’ His lecture will focus on fostering the local industry and creating its own ecosystem for furthering regional industries.
Dong-Hoon Lee of Donga ST will speak on the implications that the Fourth Industrial Revolution will bring about in the medical industry. Won-Suk Choi of FnPricing will introduce the FN business model, presenting the risks and benefits of fintech in his lecture ‘Finance: Human and Technology.’
Jae-Hong Choi of the Institute of International Development Cooperation at Korea University will give a talk titled ‘Toward the World through Global Cooperation.’ He will present on the history of Korea’s global cooperation initiatives and the role of KOICA, introducing its emerging economic and industrial cooperation model.
Professor Jeounghoon Kim, who is responsible for the public lecture program, said, “Korea now faces very diverse social economic and industrial challenges and we seem to be lost while searching for a solution. The public will have an opportunity to understand the current economic situation and its industrial implications.”
For registration and more info, please visit http://hss.kaist.ac.kr.
2017.04.26 View 6883 -
Professor Jinah Park Received the Prime Minister's Award
Professor Jinah Park of the School of Computing received the Prime Minister’s Citation Ribbon on April 21 at a ceremony celebrating the Day of Science and ICT. The awardee was selected by the Ministry of Science, ICT and Future Planning and Korea Communications Commission.
Professor Park was recognized for her convergence R&D of a VR simulator for dental treatment with haptic feedback, in addition to her research on understanding 3D interaction behavior in VR environments. Her major academic contributions are in the field of medical imaging, where she developed a computational technique to analyze cardiac motion from tagging data.
Professor Park said she was very pleased to see her twenty-plus years of research on ways to converge computing into medical areas finally bear fruit. She also thanked her colleagues and students in her Computer Graphics and CGV Research Lab for working together to make this achievement possible.
2017.04.26 View 7884 -
Professor Duck-Joo Lee Awarded the 21st Century Grand Prize
Professor Duck-Joo Lee of the Department of Aerospace Engineering was awarded the 21st Century Grand Prize in the field of technology development by the New Industry Management Academy and the 21st Leaders Club on April 13.
Professor Lee was honored in recognition of his contribution to the helicopter industry. He played a part in domestic helicopter development projects including the KUH-1 Surion (Korean Attack Helicopter), a twin-engine, transport utility helicopter as well as LAH (Light Armed Helicopter) and LCH (Light Civil Helicopter) projects.
Since joining KAIST in 1988, Professor Lee supervised more than 26 PhDs and 27 MSs. He was responsible for hosting the 1st Asian-Australian Rotorcraft Forum and Exhibition and currently serves as vice president of the American Helicopter Society and the Korea Drone Industry Promotion Association. He also participated in open online courses on K-MOOC and Coursera.
(Caption: Professor Lee (second from left in the first row) poses after receiving the award.)
2017.04.26 View 6483 -
KAIST Nanosatellite LINK Launched to the ISS
Courtesy: United Launch Alliance
The KAIST nanosatellite LINK (Little Intelligent Nanosatellite of KAIST) was successfully launched on an Atlas V booster aboard the NASA CRS-7 Mission on April 18 at Space Launch Complex 41, Cape Canaveral Air Force Station in Florida. The KAIST nanosatellite was developed by the research team led by Professor Hyochoong Bang of the Department of Aerospace Engineering.
Aboard the flight to the ISS (International Space Station) were 28 satellites including LINK. They are part of the QB50 Project, an international educational initiative which aims to deploy an array of CubeSat-mounted sensors into Earth’s thermosphere. The project is funded by the European Commission and managed by the von Karman Institute for Fluid Dynamics in Belgium.
The small satellites are hitching a lift into orbit aboard the unmanned resupply spacecraft Cygnus, with a total mass of 83 kilograms. Built to CubeSat specifications, Cygnus will deploy four of the spacecraft following its departure from the space station. LINK will conduct its scientific mission for three months at the station.
The majority of QB50 satellites carry one of three standard instrument packages, consisting of a primary instrument and an array of thermistors, thermocouples, and resistant temperature detectors. LINK is a two-unit CubeSat and weighs two kilograms. It carries an ion-neutral mass spectrometer (INMS), which measures the mass of ions and neutral atoms, as the primary payload of the QB50 project. The secondary payload is two Langmuir probes, which are in-house sensors (m-NLP) developed by Professor Kyong Wook Min’s team of the Department of Physics at KAIST. These are all geared toward collecting long-term continuous in-situ measurements of conditions in Earth’s lower thermosphere.
Professor Bang said, “The QB50 Project is being used for educational purposes. However, the LINK launch will bring a new breakthrough toward collecting information on Earth’s lower thermosphere. Building on these experiences of designing and launching the CubeSat will serve as an opportunity to verify the research results made in our lab firsthand in space.”
(Caption: LINK (Little Intelligent Nanosatellite of KAIST) was launched on an Atlast V booster aboard the NASA CRS-7 Mission on April 18.)
2017.04.25 View 8222 -
FinTech Conference by KAIST, EDHEC-Risk Institute, Princeton, and Tsinghua
KAIST will partner with EDHEC-Risk Institute, Princeton University, and Tsinghua University to host a series of annual rotation conference on FinTech. The inaugural conference will be held in Princeton on April 26 and is entitled ‘Four-University Rotating FinTech Conference: Wealth Management Systems for Individual Investors.’
The conference will facilitate discussion among all interest parties of academics, practitioners, and regulators from around the world. Professor Woo Chang Kim of the Department of Industrial & Systems Engineering will represent KAIST. Professor Kim is also the head of the Center for Wealth Management Technologies at KAIST.
In addition to Professor Kim, leading experts from the US, Asia, and Europe will present at the conference, including Andrew Yao (Turing Award recipient and founder of IIIS FinTech Center at Tsinghua University), John Bogle (founder of the Vanguard Group, and president of the Bogle Financial Markets Research Center), Lionel Martellini (director of EDHEC-Risk Institute), John Mashey (Bell Labs/Silicon Valley computer scientist/corporate executive), and John Mulvey (professor and founding member of the Bendheim Center for Finance at Princeton University).
This year’s conference will feature following sessions:
· Mass-Customization of Goal-Based Investment Solutions: The New Frontier in Digital Wealth Management Services
· Goal-Based Investment via Multi-Stage Stochastic Goal Programming for Robo-Advisor Services
· Big Data – Yesterday, Today and Tomorrow
· Applying Machine Learning Concepts for Asset Allocation and ALM
· FinTech: Drawing Strengths from Computing Theories
· Savings and Investing to Achieve Retirement Goals: An Update Given Current Market Assumptions · The Rise of Robo-Advisors: A Threat or an Opportunity for the Wealth Management Industry?
The conference will include the participation of official partner Samsung Asset Management.
2017.04.20 View 7657 -
Processable High Internal Phase Pickering Emulsion Using Depletion Attraction
Professor Siyoung Choi’s research team from the KAIST Department of Chemical & Biomolecular Engineering used physical force to successfully produce a stable emulsion.
Emulsions, commonly known as cosmetic products, refer to stably dispersed structures of oil droplets in water (or water droplets in oil). Pickering emulsions refer to emulsions stabilized using solid particles, instead of detergent. Traditionally, it is said that water and oil do not mix. Until recently, detergent was added to mix oil and water for dispersion. Emulsions have traditionally been produced using this technique and are currently used for products such as mayonnaise, sun block, and lotion.
On the other hand, Pickering emulsions have been used after stabilization of chemical treatments on solid particle surfaces to enhance adsorption power. However, there were limitations in its application, since the treatment process is complex and its applicable range remains limited. Instead of chemical treatment on Pickering emulsion surfaces, the research team mixed small macromolecules a few nanometer in size with larger solid particles (tens of nanometers to a few micrometers). This induced depletion force was used to successfully stabilize the emulsion.
Depletion force refers to the force a large number of small particles induces to aggregate the bigger particles, in order to secure free space for themselves. In short, the force induces an attraction between larger particles. Until now, depletion force could only be applied to solids and solid particles. However, the research team used macromolecules and large particles such as solid particles and oil droplets to show the applicability of depletion force between solids and liquids. By introducing macromolecules that act as smaller particles, hydrophilic solid particles enhanced the adsorption of solid particles to the oil droplet surface, while preventing dissociation from the particle surface, resulting in the maintenance of a stable state.
The research team confirmed the possibility of the simple production of various porous macromolecular materials using stable Pickering emulsions. Such porous macromolecules are expected to be applicable in separation film, systems engineering, drug delivery, and sensors, given their large surface area.
Professor KyuHan Kim, the first author said, “Until now, depletion force has only been used between solid colloid particles. This research has scientific significance since it is the first example of using depletion force between solid particles and liquid droplets.”
Professor Choi said, “Beyond its academic significance, this technology could contribute to industries and national competitiveness.” He continued, “Since this technology uses physical force, not chemical, to produce stable emulsion, it can be used regardless of the type of solid particle and macromolecule. Further, it could be used in customized porous material production for special purposes.”
The research was published in Nature Communications online on February 1. In particular, this research is significant since an undergraduate student, Subeen Kim, participated in the project as a second author through the KAIST Undergraduate Research Program (URP). This research was funded by the National Research Foundation of Korea.
(Figure 1: Images of the inner structure of porous macromolecules produced using the new technology)
(Figure 2: Images showing the measurement of rheological properties of Pickering emulsions and system processability)
(Figure 3: Images showing a stable Pickering emulsion system)
2017.04.19 View 8167 -
2017 Summer Nuclear Nonproliferation Education Program
The Nuclear Nonproliferation Education and Research Center (NEREC) at KAIST announced its 30 scholarship recipients for the 2017 Summer Nuclear Nonproliferation Education Program on April 18. The six-week program, starting from July 10, will be run in Korea, Japan, and China.
The program provides young global scholars with focused and challenging nuclear nonproliferation studies. Young scholars will be exposed to diverse science and technology policies and practices concurrently conducted in many countries and the future direction for enhancing nuclear nonproliferation. They will participate in a series of seminars, projects, international conferences, and field trips.
Since its launch in 2014, the program has educated 71 young scholars. This year, more than 150 scholars from 37 countries applied for the program, reflecting the growing reputation of the program both at home and abroad. The director of the NEREC, Professor Man-Sung Yim of the Department of Nuclear and Quantum Engineering at KAIST said that young scholars from very prestigious foreign universities have shown strong interest in the program. According to Professor Yim, this year’s recipients are from 26 universities from 16 countries including Harvard University, Oxford University, the National Research Nuclear University of Russia, and the Tokyo Institute of Technology
2017.04.19 View 6898 -
Newdin Contents Donates 'Strikezon'
Newdin Contents, an online and mobile game maker, made a gift of ‘Strikezon' to KAIST on April 19. The screen game valued at 100 million KRW will be placed in the lobby of the School of Computing, enriching the diverse physical activity options for the KAIST community. The donation was made at a ceremony attended by KAIST President Sung-Chul Shin, the CEO of the Newdin, Hyo-Kyum Kim, and Head of the School of Computing Professor Myoung Ho Kim.
At the Strikezon, students can enjoy mini baseball games indoors including a batting challenge and a pitching mode indoors for free.
President Shin thanked Mr. Kim of Newdin Contents, saying the donation will be a stepping stone for possible mutual collaborations which will play a synergistic role for technological development. Mr. Kim noted, “We are very pleased to donate the program to KAIST, which is the alma mater of Joon-Mo Hwang, the developer of Strikezon.” He added that Newdin Contents will make every effort to produce advanced game products with state of the art technology.
(Photo caption:President Sung-Chul Shin hits the ball at the Strikezon on April 19.)
2017.04.19 View 4153 -
Dr. Sejong Kim Cited as Young Scientist by the KPS
Dr. Sejong Kim, a graduate of KAIST, was cited as the Young Scientist of Optics and Quantum Electronics by the Korean Physical Society (KPC) at the 2017 KPC Spring Meeting on April 19.
Dr. Kim, now a postdoctoral scholar at the University of Technology Sydney, was recognized for the award based on her outstanding research of photonic crystals. She has published articles in Nano Letters, Advanced Materials, Optics Letters, and Optics Express 3 as the first author and co-first author. She also won the silver prize at the Samsung HumanTech Paper Award in the field of Physical Devices and Science as the first author in 2013, one of the most prestigious scientific paper awards in Korea.
2017.04.18 View 3173 -
Tactile Sensor for Robot Skin Advanced by KAIST Team
The joint research team of Professors Jung Kim and Inkyu Park from the Department of Mechanical Engineering developed a tactile sensor that can act as skin for robots using silicon and carbon materials. This technology produced a sensor that can absorb shock and distinguish various forms of touch, and it is hoped to be used as robot skin in the future.
Skin serves an important role as the largest organ of the human body. As well as protecting major organs from external shock, skin also measures and distinguishes delicate tactile information and transfer it to the nervous system.
Current robotic sensory technology allows robots to have visual and auditory systems at nearly similar levels to human capacity, but there are limitations in tactile sensors that can detect changes in the environment throughout the body. To apply skin with similar functions as humans to robots, it is essential to develop skin sensor technology with high flexibility and high shock absorption. Another limitation for developing robot skin was connecting numerous sensors all over the body using electric wiring.
To overcome this problem, the research team combined silicon and carbon nanotubes (CNT) to produce a composite, which was then used in combination with a medical imaging technique called electrical impedance tomography (EIT). This led to technology that can distinguish various forms of force over a large area without electrical wiring.
The sensing material can distinguish the location and the size of various forms by touch, and thus can be applied to robot skin that can absorb shock as well as serves as a 3D computer interface and tactile sensor. It can withstand strong force such as a hammer strike, and can be re-used even after partial damage to the sensor by filling and hardening the damaged region with composite. Further, the sensor can be made by filling a 3D shape frame with silicon-nanotube composite. Using this technology, new forms of computer interaces can be developed with both curbed and flat surfaces.
This research was conducted through a collaboration between Professor Park, an expert in nanostructures and sensors, and Professor Kim, an expert in bio-robotics. Hence, the technology is likely to be applied in real products.
Professor Kim said, “Flexible tactile sensors can not only be directly adhered to the body, but they also provides information on modified states in multiple dimensions”. He continued, “This technology will contribute to the soft robot industry in the areas of robot skin and the field of wearable medical appliances.”
Professor Park said, “This technology implemented a next-generation user interface through the integration of functional nano-composite material and computer tomography.”
This research was published in Scientific Reports, a sister journal of Nature, online on January 25. This research was conducted as joint research by first author Hyo-Sang Lee, as well as Donguk Kwon and Ji-seung Cho, and was funded by the Ministry of Science, ICT and Future Planning.
(Fiigrue 1: Robotic hand responding to resistance via a connection with the developed tactile sensor)
(Figure 2: Manufacturing process for pressure-resistant composite using silicon rubber and carbon nanotubes)
(Figure 3: Computer interface using pressure-resistant composite)
2017.04.17 View 10811