Graduate
-
Marien Buissonniere Awarded the 9th Grand Award for Future Strategy
Global healthcare and humanitarian activist honored by the Grand Award for Future Strategy
The Moon Soul Graduate School of Future Strategy awarded the 9th Grand Award for Future Strategy to Marine Buissonniere, an independent advisor and practitioner in the fields of global health and humanitarian action. She currently works as a senior advisor to the Prevent Epidemics team at Resolve to Save Lives. She also co-chairs Doctors Without Borders’ Transformational Investment Capacity.
Buissonniere was recognized for designing and implementing global response strategies in global strife and disaster stricken areas over the 25 years while serving as secretary general of Doctors Without Borders. She has been working with various government agencies around the world including Resolve to Save Lives to respond to the Covid-19 pandemic and preparing global future strategies for the post-pandemic era.
The Grand Award for Future Strategy recognizes individual and organization who have contributed to the nation and humanity through future research and strategies in the fields of science and technology, economy and industry, society and culture, politics and governance, and resources and environment.
The selection committee place particular emphasis on her humanitarian efforts toward North Korea. She was in charge of the task force for resuming the health project in North Korea and facilitated the North Korean program in 2002. She also played a significant role in raising awareness of North Korea’s humanitarian issues in the international community by lecturing at Columbia and Princeton.
Buissonniere said during the awards ceremony held online on November 5, “I am very grateful to receive this award from KAIST, a world’s top-flight university as well as from South Korea related to the Korean Peninsula and North Korea, where I have spent most of my life. What makes this award even more special is it is about the international medical relief activities and system innovations that I’ve devoted my life to over the last 25 years. I am going to continue this journey to help many people in difficult situations. Eventually, I would like to make it possible for those people in need to make their own future by themselves.”
2021.11.11 View 6683 -
Minister of Justice Meets with KAIST International Community Members
The Office of Immigration Service in Daejeon will dispatch On-Site Immigration Service Team at the campus once a week
Minister of Justice Beom Kye Park met with international students and faculty members on October 29 at the KAIST campus and promised the government’s prompt and flexible revision of the process for acquiring legal residency and Korean citizenship for talents in the fields of science and technology.
During the meeting to discuss immigration difficulties with foreign students, researchers, and faculty at KAIST, many KAIST international students expressed their wishes to continue their research in Korea after graduation and asked for legal support to acquire permanent residence status.
International faculty members including PhD and Master’s candidate and postdoc fellows attended the meeting along with KAIST President Kwang Hyung Lee and Assistant Vice President of the International Office Scott Knowles.
Currently, there are 1,100 international members on campus: 421 undergraduates, 236 Master’s student, 266 PhD candidates, 79 researchers, and 67 faculty members.
President Lee said, “It is prerequisite to nurture the outstanding talents who earned their degrees in Korea for raising our national competitiveness. We would like to ask the government to ease the current system to embrace those excellent talents. That will definitely be necessary for securing new talents as well as for invigorating the domestic industry and R&D sector, which will lead to attracting the next excellent groups of talented students from abroad.”
Minister Park said that the government now needs more inclusive immigration policies granting legal residency and citizenship to the highly talented group. He added that the ministry will make every effort to help our degree holders acquire the relevant legal status to settle down here.
Meanwhile, the Office of Immigration Services in Daejeon set up the ‘On-Site Immigration Service’ at the campus and provided one-on-one consultation services for KAIST international community regarding extension of stays and alien registration affairs.
The On-Site Immigration Service will continue at the campus once a week for convenience of KAIST international community in the very near future.
2021.10.29 View 5210 -
3 KAIST PhD Candidates Selected as the 2021 Google PhD Fellows
PhD candidates Soo Ye Kim and Sanghyun Woo from the KAIST School of Electrical Engineering and Hae Beom Lee from the Kim Jaechul Graduate School of AI were selected as the 2021 Google PhD Fellows. The Google PhD Fellowship is a scholarship program that supports graduate school students from around the world that have produced excellent achievements from promising computer science-related fields. The 75 selected fellows will receive ten thousand dollars of funding with the opportunity to discuss research and receive one-on-one feedback from experts in related fields at Google.
Kim and Woo were named fellows in the field of "Machine Perception, Speech Technology and Computer Vision" with research of deep learning based super-resolution and computer vision respectively. Lee was named a fellow in the field of "Machine Learning" for his research in meta-learning.
Kim's research includes the formulation of novel methods for super-resolution and HDR video restoration and deep joint frame interpolation and super-resolution methods. Many of her works have been presented in leading conferences in computer vision and AI such as CVPR, ICCV, and AAAI. In addition, she has been collaborating as a research intern with the Vision Group Team at Adobe Research to study depth map refinement techniques.
(Kim's research on deep learning based joint super-resolution and inverse tone-mapping framework for HDR videos)
Woo’s research includes an effective deep learning model design based on the attention mechanism and learning methods based on self-learning and simulators. His works have been also presented in leading conferences such as CVPR, ECCV, and NeurIPS. In particular, his work on the Convolutional Block Attention Module (CBAM) which was presented at ECCV in 2018 has surpassed over 2700 citations on Google Scholar after being referenced in many computer vision applications. He was also a recipient of Microsoft Research PhD Fellowship in 2020.
(Woo's research on attention mechanism based deep learning models)
Lee’s research focuses effectively overcoming various limitations of the existing meta-learning framework. Specifically, he proposed to deal with a realistic task distribution with imbalances, improved the practicality of meta-knowledge, and made meta-learning possible even in large-scale task scenarios. These various studies have been accepted to numerous top-tier machine learning conferences such as NeurIPS, ICML, and ICLR. In particular, one of his papers has been selected as an oral presentation at ICLR 2020 and another as a spotlight presentation at NeurIPS 2020.
(Lee's research on learning to balance and continual trajectory shifting)
Due to the COVID-19 pandemic, the award ceremony was held virtually at the Google PhD Fellowship Summit from August 31st to September 1st. The list of fellowship recipients is displayed on the Google webpage.
2021.10.18 View 6178 -
Diva Sumi Jo to Join the KAIST Faculty
Visiting Distinguished Professor Jo will enrich KAIST’s scholarship and inspire futuristic art and technology research
Soprano Sumi Jo will join the KAIST faculty from the spring 2022 semester. Named as a visiting distinguished professor in the Graduate School of Culture Technology, she will give special leadership lectures. Her tenure will be through September 2024.
Jo joined the appointment ceremony held online at KAIST on October 14 from Portugal and expressed her high expectations for teaching KAIST students from next year. “I am very grateful for this opportunity to meet students at KAIST, the birthplace of advanced science and technology in Korea,” she said.
KAIST President Kwang Hyung Lee, who has stressed the importance of humanities and the arts in convergence studies of science and technology, lauded her joining the faculty as a big asset who will enrich KAIST’s scholarship. “Soprano Sumi Jo rose to stardom on the global music stage with her unrivaled talent and effort. I truly believe her experience and passion will inspire our students to expand their horizon of thought and knowledge,” said President Lee.
Distinguished Professor Jo will also participate in convergence research at the Graduate School of Culture Technology with KAIST professors and many other experts. The Sumi Jo Performing Arts Research Center at the Graduate School of Culture Technology will conduct research on the converging of imaging and audio processing technologies that will enhance virtual artists’ performances. Distinguished Professor Jo explained, “The world is changing so fast. I look forward to working on culture technology research at KAIST that will raise our life quality.”
Professor Juhan Nam from the Graduate School of Culture Technology said, “We look forward to working closely with her and her team to develop research themes that envision futuristic art combined with technology such as the metaverse and non-fungible tokens (NFTs).
Coloratura soprano Jo was born in Seoul and educated at Seoul National University and the Conservatorio Santa Cecilia in Italy. Among her teachers were Carolo Bergonzi and Giasnnelas Borelli. Following her graduation from the Conservatorio Santa Cecilia in 1985, she swept major international competitions in Seoul and Europe. In 1986, she was unanimously awarded the first prize in the Carlo Alberto Cappelli International Competition in Verona which is open only to the first-prize winners of major competitions.
Since her debut in the role of Gilda in Verdi’s Rigolleto in Italy in 1986, she has performed on the world's biggest stages along with noted maestros such as Herbert von Karajan, Georg Solti, Zubin Mehta, and James Levine. Distinguished Professor Jo, one of the most sought-after sopranos in the world, released more than 40 albums.
2021.10.15 View 6024 -
Two Researchers Designated as SUHF Fellows
Professor Taeyun Ku from the Graduate School of Medical Science and Engineering and Professor Hanseul Yang from the Department of Biological Sciences were nominated as 2021 fellows of the Suh Kyungbae Foundation (SUHF).
SUHF selected three young promising scientists from 53 researchers who are less than five years into their careers. A panel of judges comprised of scholars from home and abroad made the final selection based on the candidates’ innovativeness and power to influence. Professor You-Bong Hyun from Seoul National University also won the fellowship.
Professor Ku’s main topic is opto-connectomics. He will study ways to visualize the complex brain network using innovative technology that transforms neurons into optical elements.
Professor Yang will research the possibility of helping patients recover from skin diseases or injuries without scars by studying spiny mouse genes.
SUHF was established by Amorepacific Group Chairman Suh Kyungbae in 2016 with 300 billion KRW of his private funds. Under the vision of ‘contributing to humanity by supporting innovative discoveries of bioscience researchers,’ the foundation supports promising Korean scientists who pioneer new fields of research in biological sciences.
From 2017 to this year, SUHF has selected 20 promising scientists in the field of biological sciences. Selected scientists are provided with up to KRW 500 million each year for five years. The foundation has provided a total of KRW 48.5 billion in research funds to date.
2021.09.15 View 8600 -
The Dynamic Tracking of Tissue-Specific Secretory Proteins
Researchers develop a versatile and powerful tool for studying the spatiotemporal dynamics of secretory proteins, a valuable class of biomarkers and therapeutic targets
Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. This method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1.
Secretory proteins released into the blood play essential roles in physiological systems. They are core mediators of interorgan communication, while serving as biomarkers and therapeutic targets.
Previous studies have analyzed conditioned media from culture models to identify cell type-specific secretory proteins, but these models often fail to fully recapitulate the intricacies of multi-organ systems and thus do not sufficiently reflect biological realities.
These limitations provided compelling motivation for the research team led by Jae Myoung Suh and his collaborators to develop techniques that could identify and resolve characteristics of tissue-specific secretory proteins along time and space dimensions.
For addressing this gap in the current methodology, the research team utilized proximity-labeling enzymes such as TurboID to label secretory proteins in endoplasmic reticulum lumen using biotin. Thereafter, the biotin-labeled secretory proteins were readily enriched through streptavidin affinity purification and could be identified through mass spectrometry.
To demonstrate its functionality in live mice, research team delivered TurboID to mouse livers via an adenovirus. After administering the biotin, only liver-derived secretory proteins were successfully detected in the plasma of the mice. Interestingly, the pattern of biotin-labeled proteins secreted from the liver was clearly distinctive from those of hepatocyte cell lines.
First author Kwang-eun Kim from the Graduate School of Medical Science and Engineering explained, “The proteins secreted by the liver were significantly different from the results of cell culture models. This data shows the limitations of cell culture models for secretory protein study, and this technique can overcome those limitations. It can be further used to discover biomarkers and therapeutic targets that can more fully reflect the physiological state.”
This work research was supported by the National Research Foundation of Korea, the KAIST Key Research Institutes Project (Interdisciplinary Research Group), and the Institute for Basic Science in Korea.
-PublicationKwang-eun Kim, Isaac Park et al., “Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice,” Nature Communications on Sept.1,
2021(https://doi.org/10.1038/s41467-021-25546-y)
-ProfileProfessor Jae Myoung Suh Integrated Lab of Metabolism, Obesity and Diabetes Researchhttps://imodkaist.wixsite.com/home
Graduate School of Medical Science and Engineering College of Life Science and BioengineeringKAIST
2021.09.14 View 9424 -
Recipe for Success: Reputations Start from Inner Circles
A study on social network data of EDM DJs finds the relationship between social standing and identity building
If you would like to succeed in your career, carve out your own distinctiveness, then break your boundaries along with collaborators. This sounds very common. However, a study on social networks has proven that is the recipe for success.
A recent research on electric dance music DJs’ music identity and their reputation found that music DJs with a distinct genre identity as well as network positions combining brokerage and cohesion tend to place higher in terms of their social standing.
What do Calvin Harris, the star of Electro house, Diplo, the icon of Moombahton & Trap, Sebastian Ingrosso, the master of Progressive House, and Armin Van Buuren, the leader of Trance have in common? One commonality of these star DJs in the electronic music market is that they are the leaders who build their genres with solid musical identities and are artists who constantly try experimental and innovative connections with other genres.
Professor Wonjae Lee and Dr. Hyeongseok Wi from the Graduate School of Culture and Technology analyzed the playlist data performed by electronic dance music (EDM) DJs at several EDM festivals that were popular around the world before COVID-19 and the track data that they released during that period.
“This study investigates how social standing is attained within a professional group of artists whose members play a key role in evaluating their artistic products in the EDM market,” said Professor Lee.
Particularly, the team considered DJs' social standing as an effective means of ensuring the quality of their artwork in emerging music markets such as EDM and identified two important factors, the musical identity and the social position within the professional DJ’s group.
They analyzed the data from 3,164 playlists of 815 DJs who performed at nine festivals held from 2013 to 2016 as a sort of citation network among DJs, and transformed it into network data to measure social positions among the DJs. They considered the DJs who received a lot of citations from other DJs as having a high social standing. In addition, the genre, beats per minute (BPM), and key scale data of the songs released during the period were quantified to analyze the association with the musical identity.
First, the results of analysis of the released track data demonstrated that focused distinct musical identity is correlated with social standing among EDM DJs. The EDM market is an emerging specialist market that is constantly developing and differentiating new styles and genres. It includes artists who establish value criteria and demarcate categorical space into separate identity positions reflecting the artistic forms of a similar type.
Second, this study focuses on the two advantages of two types of social positioning, brokerage and cohesive, which can effectively reduce uncertainty in the market. The results show that DJs with a hybrid position, combining elements of both brokerage and cohesion, have higher social standing. This hybrid position is the most advantageous position for controlling new opportunities and inflows of resources and for utilizing them. Unlike existing studies that divide the merits of the two positions into a dichotomy, this study follows the practice of recent studies that show that the two positions can generate synergy in a complementary manner.
The remix culture prominent in EDM provides a convincing explanation for this phenomenon. Because constructing playlist sets represents a DJ’s main specialty, the ability to creatively combine a variety of tracks using one’s own artistic style is crucial. To showcase their remix skills, DJs skillfully select tracks to maximize the displays of their talent. Recognized DJs prefer to select tracks from other genres, borrowing from existing contexts and creating new reinterpretations while drawing upon their own musical backgrounds.
“Acquiring social acknowledgement within a professional group is an effective way to ensure the quality of products they produce and a strong reputation,” explained Professor Lee.
The research team also pointed out the unique case of Techno DJs, who are showing Galápagos syndrome by avoiding crossover between genres and sticking to their own musical identity, unlike most genres in EDM. This research was reported in PLos ONE on Aug. 25 and funded by KAIST and the BK21 Plus Postgraduate Organization for Content Science.
-ProfileProfessor Wonjae LeeGraduate School of Culture TechnologyKAIST
-PublicationHyeongseok Wi, Wonjae Lee “Stars inside have reached outside: The effects of electronic dance music DJ’s social standing and musical identity on track success,” Aug.25, 2021 PLosONE (https://doi.org/10.1371/journal.pone.0254618)
2021.09.09 View 7142 -
Digital Big Bang, Metaverse Technologies
The GSI Forum 2021 will explore the potential of new metaverse technologies that will change our daily lives
KAIST will be hosting a live online international forum on Sept.8 at 9 am (KST) through its KAIST YouTube channel. The forum will explore global trends regarding metaverse technology innovations and applications and discuss how we can build a new technology ecosystem.
Titled `Digital Big Bang, Metaverse Technology,' the Global Strategy Institute-International Forum 2021 will be the fourth event of its kind, following the three international forums held in 2020. The forum will delve into the development trends of metaverse platforms and AR/VR technologies and gather experts to discuss how such technologies could transform multiple aspects of our future, including education.
President Kwang Hyung Lee explains in his opening remarks that new technologies are truly opening a new horizon for our lives, saying, “In the education sector, digital technology will also create new opportunities to resolve the longstanding pedagogical shortfalls of one-way knowledge delivery systems. New digital technologies will help to unlock the creativity of our students. Education tailored to the students’ individual levels will not only help them accumulate knowledge but improve their ability to use it. Universities around the world are now at the same starting line. We should carve out our own distinct metaverse that is viable for human interactions and diverse technological experiences that promote students’ creativity and collaborative minds.”
Minster of Science and ICT Hyesook Lim will introduce how the Korean government is working to develop metaverse industries as a new potential engine of growth for the future in her welcoming remarks. The government’s efforts include collaborations with the private sector, investments in R&D, the development of talent, and regulatory reforms. Minister Lim will also emphasize the importance of national-level discussions regarding the establishment of a metaverse ecosystem and long-term value creation.
The organizers have invited global experts to share their knowledge and insights.
Kidong Bae, who is in charge of the KT Enterprise Project and ‘Metaverse One Team’ will talk about the current trends in the metaverse market and their implications, as well as KT’s XR technology references. He will also introduce strategies to establish and utilize a metaverse ecosystem, and highlight their new technologies as a global leader in 5G networks.
Jinha Lee, co-founder and CPO of the American AR solution company Spatial, will showcase a remote collaboration office that utilizes AR technology as a potential solution for collaborative activities in the post-COVID-19 era, where remote working is the ‘new normal.’ Furthermore, Lee will discuss how future workplaces that are not limited by space or distance will affect our values and creativity.
Professor Frank Steinicke from the University of Hamburg will present the ideal form of next-generation immersive technology that combines intelligent virtual agents, mixed reality, and IoT, and discuss his predictions for how the future of metaverse technology will be affected.
Marco Tempest, a creative technologist at NASA and a Director’s Fellow at the MIT Media Lab, will also be joining the forum as a plenary speaker. Tempest will discuss the potential of immersive technology in media, marketing, and entertainment, and will propose a future direction for immersive technology to enable the sharing of experiences, emotions, and knowledge.
Other speakers include Beomjoo Kim from Unity Technologies Korea, Professor Woontaek Woo from the Graduate School of Culture Technology at KAIST, Vice President of Global Sales at Labster Joseph Ferraro, and CEO of 3DBear Jussi Kajala. They will make presentations on metaverse technology applications for future education.
The keynote session will also have an online panel consisting of 50 domestic and overseas metaverse specialists, scientists, and teachers. The forum will hold a Q&A and discussion session where the panel members can ask questions to the keynote speakers regarding the prospects of metaverse and immersive technologies for education.
GSI Director Hoon Sohn stated, "KAIST will seize new opportunities that will arise in a future centered around metaverse technology and will be at the forefront to take advantage of the growing demand for innovative science and technology in non-contact societies. KAIST will also play a pivotal role in facilitating global cooperation, which will be vital to establish a metaverse ecosystem.”
2021.09.07 View 9288 -
Genomic Data Reveals New Insights into Human Embryonic Development
KAIST researchers have used whole-genome sequencing to track the development from a single fertilized-egg to a human body
Genomic scientists at KAIST have revealed new insights into the process of human embryonic development using large-scale, whole-genome sequencing of cells and tissues from adult humans. The study, published in Nature on Aug.25, is the first to analyse somatic mutations in normal tissue across multiple organs within and between humans.
An adult human body comprises trillions of cells of more than 200 types. How a human develops from a single fertilized egg to a fully grown adult is a fundamental question in biomedical science. Due to the ethical challenges of performing studies on human embryos, however, the details of this process remain largely unknown.
To overcome these issues, the research team took a different approach. They analysed genetic mutations in cells taken from adult human post-mortem tissue. Specifically, they identified mutations that occur spontaneously in early developmental cell divisions. These mutations, also called genomic scars, act like unique genetic fingerprints that can be used to trace the embryonic development process.
The study, which looked at 334 single-cell colonies and 379 tissue samples from seven recently deceased human body donors, is the largest single-cell, whole-genome analysis carried out to date. The researchers examined the genomic scars of each individual in order to reconstruct their early embryonic cellular dynamics.
The result revealed several key characteristics of the human embryonic development process. Firstly, mutation rates are higher in the first cell division, but then decrease to approximately one mutation per cell during later cell division. Secondly, early cells contributed unequally to the development of the embryo in all informative donors, for example, at the two-cell stage, one of the cells always left more progeny cells than the other. The ratio of this was different from person to person, implying that the process varies between individuals and is not fully deterministic.
The researchers were also able to deduce the timing of when cells begin to differentiate into individual organ-specific cells. They found that within three days of fertilization, embryonic cells began to be distributed asymmetrically into tissues for the left and right sides of the body, followed by differentiation into three germ layers, and then differentiation into specific tissues and organs.
“It is an impressive scientific achievement that, within 20 years of the completion of human genome project, genomic technology has advanced to the extent that we are now able to accurately identify mutations in a single-cell genome,” said Professor Young Seok Ju from the Graduate School of Medical Science and Engineering at KAIST. “This technology will enable us to track human embryogenesis at even higher resolutions in the future.”
The techniques used in this study could be used to improve our understanding of rare diseases caused by abnormalities in embryonic development, and to design new precision diagnostics and treatments for patients.
The research was completed in collaboration with Kyungpook National University Hospital, the Korea Institute of Science and Technology Information, Catholic University of Korea School of Medicine, Genome Insights Inc, and Immune Square Inc. This work was supported by the Suh Kyungbae Foundation, the Ministry of Health and Welfare of Korea, the National Research Foundastion of Korea.
-PublicationSeongyeol Park, Nanda Mali, Ryul Kim et al. ‘Clonal dynamics in early human embryogenesis inferred from somatic mutation’ Nature Online ahead of print, Aug. 25, 2021 (https://doi.org/10.1038/s41586-021-03786-8)
-ProfileProfessor Young Seok JuLab of Cancer Genomics (https://www.julab.kaist.ac.kr/)Graduate School of Medical Science and EngineeringKAIST
2021.08.31 View 9177 -
A Mechanism Underlying Most Common Cause of Epileptic Seizures Revealed
An interdisciplinary study shows that neurons carrying somatic mutations in MTOR can lead to focal epileptogenesis via non-cell-autonomous hyperexcitability of nearby nonmutated neurons
During fetal development, cells should migrate to the outer edge of the brain to form critical connections for information transfer and regulation in the body. When even a few cells fail to move to the correct location, the neurons become disorganized and this results in focal cortical dysplasia. This condition is the most common cause of seizures that cannot be controlled with medication in children and the second most common cause in adults.
Now, an interdisciplinary team studying neurogenetics, neural networks, and neurophysiology at KAIST has revealed how dysfunctions in even a small percentage of cells can cause disorder across the entire brain. They published their results on June 28 in Annals of Neurology.
The work builds on a previous finding, also by a KAIST scientists, who found that focal cortical dysplasia was caused by mutations in the cells involved in mTOR, a pathway that regulates signaling between neurons in the brain.
“Only 1 to 2% of neurons carrying mutations in the mTOR signaling pathway that regulates cell signaling in the brain have been found to include seizures in animal models of focal cortical dysplasia,” said Professor Jong-Woo Sohn from the Department of Biological Sciences. “The main challenge of this study was to explain how nearby non-mutated neurons are hyperexcitable.”
Initially, the researchers hypothesized that the mutated cells affected the number of excitatory and inhibitory synapses in all neurons, mutated or not. These neural gates can trigger or halt activity, respectively, in other neurons. Seizures are a result of extreme activity, called hyperexcitability. If the mutated cells upend the balance and result in more excitatory cells, the researchers thought, it made sense that the cells would be more susceptible to hyperexcitability and, as a result, seizures.
“Contrary to our expectations, the synaptic input balance was not changed in either the mutated or non-mutated neurons,” said Professor Jeong Ho Lee from the Graduate School of Medical Science and Engineering. “We turned our attention to a protein overproduced by mutated neurons.”
The protein is adenosine kinase, which lowers the concentration of adenosine. This naturally occurring compound is an anticonvulsant and works to relax vessels. In mice engineered to have focal cortical dysplasia, the researchers injected adenosine to replace the levels lowered by the protein. It worked and the neurons became less excitable.
“We demonstrated that augmentation of adenosine signaling could attenuate the excitability of non-mutated neurons,” said Professor Se-Bum Paik from the Department of Bio and Brain Engineering.
The effect on the non-mutated neurons was the surprising part, according to Paik. “The seizure-triggering hyperexcitability originated not in the mutation-carrying neurons, but instead in the nearby non-mutated neurons,” he said.
The mutated neurons excreted more adenosine kinase, reducing the adenosine levels in the local environment of all the cells. With less adenosine, the non-mutated neurons became hyperexcitable, leading to seizures.
“While we need further investigate into the relationship between the concentration of adenosine and the increased excitation of nearby neurons, our results support the medical use of drugs to activate adenosine signaling as a possible treatment pathway for focal cortical dysplasia,” Professor Lee said.
The Suh Kyungbae Foundation, the Korea Health Technology Research and Development Project, the Ministry of Health & Welfare, and the National Research Foundation in Korea funded this work.
-Publication:Koh, H.Y., Jang, J., Ju, S.H., Kim, R., Cho, G.-B., Kim, D.S., Sohn, J.-W., Paik, S.-B. and Lee, J.H. (2021), ‘Non–Cell Autonomous Epileptogenesis in Focal Cortical Dysplasia’ Annals of Neurology, 90: 285 299. (https://doi.org/10.1002/ana.26149)
-ProfileProfessor Jeong Ho Lee Translational Neurogenetics Labhttps://tnl.kaist.ac.kr/ Graduate School of Medical Science and Engineering KAIST
Professor Se-Bum Paik Visual System and Neural Network Laboratory http://vs.kaist.ac.kr/ Department of Bio and Brain EngineeringKAIST
Professor Jong-Woo Sohn Laboratory for Neurophysiology, https://sites.google.com/site/sohnlab2014/home Department of Biological SciencesKAIST
Dr. Hyun Yong Koh Translational Neurogenetics LabGraduate School of Medical Science and EngineeringKAIST
Dr. Jaeson Jang Ph.D.Visual System and Neural Network LaboratoryDepartment of Bio and Brain Engineering KAIST
Sang Hyeon Ju M.D.Laboratory for NeurophysiologyDepartment of Biological SciencesKAIST
2021.08.26 View 13210 -
KAIST KPC4IR Presents the AI Global Guide for Healthcare
The benchmark for the responsible usage of AI technology in the healthcare sector will promote clarity and high standards for technological applications
The KAIST Korea Policy Center for the Fourth Industrial Revolution (KPC4IR) published 'Using AI to Support Healthcare Decisions: A Guide for Society.' This global guide is designed to serve as a benchmark for the responsible usage of AI technologies, and will promote clarity and high standards for technological applications in the healthcare sector. The guide details what should be considered when making clinical decisions to help reduce the chances of the AI giving false or misleading results.
The KPC4IR presented the guide in collaboration with the Lloyd’s Register Foundation Institute for the Public Understanding of Risk at the National University of Singapore (NUS IPUR) and Sense about Science, a non-profit organization in the UK specialized in science communication, during the 2021 SIG-KDD (Special Interest Group on Knowledge Discovery and Data Mining) Conference on August 15.
AI technology is being widely used in the healthcare sector and has already proved its accuracy and efficiency in diagnosing and predicting diseases. Despite its huge impact on our daily lives in every sector of society, AI technology has some drawbacks and comes with risks, especially due to biased algorithms.
“We focused on the ‘reliability’ of AI applications in the healthcare sector to make all data well represented, in good quality. The technology will eventually innovate to better serve the people’s new demand, especially critical demands for safety and precision in healthcare services. This global guide will help both developers and people’s understanding of the appropriate technology applications,” says Director So Young Kim at the KPC4IR.
The guide, for instance, says that to scrutinize quality and reliability, the source of the data must be clearly known; the data must have been collected or selected for the purpose it’s being used for; the limitations and assumptions for that purpose have been clearly stated; the biases have been addressed; and it has been properly tested in the real world. It also reflects the importance of the representativeness of data that will affect the accuracy of the AI applications.
“By being transparent and demonstrating the steps taken to check that the AI is reliable, researchers and developers can help give people confidence about providing their data,” the guide states.
For this guide, the KPC4IR and its collaborators collected data after working with numerous experts from the Graduate School of AI at KAIST, the Science and Technology Policy Institute in Korea, Asan Medical Center in Seoul, Seoul National University Bundang Hospital, and AI solution companies.
2021.08.17 View 8345 -
A Study Reveals What Triggers Lung Damage during COVID-19
A longitudinal study of macrophages from SARS-CoV-2 infected lungs offers new insights into dynamic immunological changes
A KAIST immunology research team found that a specific subtype of macrophages that originated from blood monocytes plays a key role in the hyper-inflammatory response in SARS-CoV-2 infected lungs, by performing single-cell RNA sequencing of bronchoalveolar lavage fluid cells. This study provides new insights for understanding dynamic changes in immune responses to COVID-19.
In the early phase of COVID-19, SARS-CoV-2 infected lung tissue and the immediate defense system is activated. This early and fast response is called ‘innate immunity,’ provided by immune cells residing in lungs. Macrophages are major cell types of the innate immune system of the lungs, and newly differentiated macrophages originating from the bloodstream also contribute to early defenses against viruses.
Professor Su-Hyung Park and his collaborators investigated the quantitative and qualitative evaluation of immune responses in the lungs of SARS-CoV-2 infected ferrets. To overcome the limitations of research using patient-originated specimens, the researchers used a ferret infection model to obtain SARS-CoV-2 infected lungs sequentially with a defined time interval.
The researchers analyzed the 10 subtypes of macrophages during the five-day course of SARS-CoV-2 infection, and found that infiltrating macrophages originating from activated monocytes in the blood were key players for viral clearance as well as damaged lung tissue. Moreover, they found that the differentiation process of these inflammatory macrophages resembled the immune responses in the lung tissue of severe COVID-19 patients.
Currently, the research team is conducting a follow-up study to identify the dynamic changes in immune responses during the use of immunosuppressive agents to control hyper-inflammatory response called ‘cytokine storm’ in patients with COVID-19.
Dr. Jeong Seok Lee, the chief medical officer at Genome Insight Inc., explained, “Our analysis will enhance the understanding of the early features of COVID-19 immunity and provide a scientific background for the more precise use of immunosuppressive agents targeting specific macrophage subtypes.”
“This study is the first longitudinal study using sequentially obtained immune cells originating from SARS-CoV-2 infected lungs. The research describes the innate immune response to COVID-19 using single cell transcriptome data and enhances our understanding of the two phases of inflammatory responses,” Professor Park said.
This work was supported by the Ministry of Health and Welfare and KAIST, and was published in Nature Communications on July 28.
-PublicationSu-Hyung Park, Jeong Seok Lee, Su-Hyung Park et al. “Single-cell transcriptome of bronchoalverolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets” Nature Communications (https://doi.org/10.1038/s41467-021-24807-0)
-ProfileProfessor Su-Hyung ParkLaboratory of Translational Immunology and Vaccinologyhttps://ltiv.kaist.ac.kr/
Graduate School of Medical Science and EngineeringKAIST
2021.08.04 View 12796