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Therapy developed to induce Angiogenesis of Retina
- Junyeop Lee, Graduate School of Medical Sciences and Engineering - Research results expected to be applied for treatment of diabetic retinopathy A major clue to treatment of retinovascular disease, which causes blindness, has been found. The key to protection of the retinal nerve is the angiogenic protein that promotes healthy retinal vessel growth around the retina, which usually does not receive blood supply readily. This research offers a beginning to the possible improvement of therapy for diabetic retinopathy1 and retinopathy of prematurity2. Also important to the research is the fact that the ophthalmology specialist researcher, currently undergoing professional training, provided the results. KAIST Graduate School of Medical Sciences and Engineering’s Junyeop Lee is the opthalmology specialist, who carried out the research under supervision by academic advisers Gyuyeong Go and Wookjun Yoo. The Ministry of Science, ICT and Future Planning as well as the National Research Foundation of Korea have funded his research. The research results have been published as a cover paper on ‘Science Translational Medicine’ on 18th August. This journal is a sister publication of Science, which is prestigious in the field of translational medicine that ties the basic science with clinical medicine. (Thesis title: Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy) The traditional treatment of diabetic retinopathy includes laser photocoagulation to destroy the retinal tissues or antibody therapeutics, which prevents vessel proliferation and blood leaking. The advantage of antibody therapeutics3 is that it retains the retinal nerves, however, it is not the fundamental solution but merely a temporary one, which requires repeated treatments. The research team identified that Angiopoietin-14 protein, known as essential for growth and stabilization of vessels, also plays an important role in retinal vessel growth. The protein protects the retinal nerves, as well as provides improvement for retinal ischemia5 that is the root cause of vision loss due to retinal hemorrhages. It is expected to become a key to finding fundamental treatment method – by providing sufficient blood supply to the retina, thereby preserving the retinal nerve functions. The results show that administration of Angiopoietin-1 to retinopathy mouse model promotes growth of healthy vessel growth, further preventing abnormal vessel growth, retinal hemorrhage and vision loss due to retinal ischemia. Junyeop Lee said, “This research has identified that Angiopoietin-1 is an important factor in retinal vessel generation and stabilization. The paradigm will shift from traditional treatment method, which prevents vessel growth, to a new method that generates healthy vessels and strengthens vessel functions.” 1 Diabetic retinopathy: This retinovascular disease is a diabetic complication caused by insufficient blood supply. It is the major causes of blindness in adults. 2 Retinopathy of prematurity: The retinal vascular disease that occurs in premature infants with incomplete retinal vascular development. It is also the most common cause of blindness in children. 3 Antibody Therapeutics: Antibody developed to selectively inhibit abnormal blood vessel growth and leakage. Typical antibody therapeutics is Avastin and Lucentis, which hinder vascular endothelial growth factor (VEGF). 4 Angiopoietin-1: A critical growth factor that induces the production of healthy blood vessels and maintains the stability of the created vessel. 5 Retinal ischemia: State of ailment where retinal tissue blood supply is not sufficient. Figure 1. Retinopathy mouse models show that, in comparison to the control group, the VEGF-Trap treatment and Angiopoietin-1 (Ang1) treatment groups significantly suppresses the pathological vascular proliferation. In addition, the Ang 1 group show vessel growth toward the central avascular area (region of retinal ischemia), which is not observed in VEGF-Trap treatment. Figure 2. Reduced retinal ischemia, retinal bleeding and blood vessel normalization by Angiopoietin-1. Retinal ischemic region (arrow) and retinal bleeding significantly reduced in the Angiopoietin-1 (Ang1) treatment model in comparison to control group (left). The newly generated vessels in Ang 1 model are structurally supported by perivascular cells as normal retinal vessels do (right).
2013.10.12
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Jellyfish Exterminator Robot Developed
Formation Control demonstrated by JEROS - Trial performance successfully completed with three assembly robots - A team led by KAIST Civil and Environmental Engineering Department’s Professor Hyeon Myeong has just finished testing the cooperative assembly robot for jellyfish population control, named JEROS, in the field. The rising number of accidents and financial losses by fishing industry, estimated at 300 billion won per year, caused by the recent swarm of jellyfish in coastal waters has been a major problem for many years. The research team led by Prof. Hyeon Myeong began developing an unmanned automated system capable of eradicating jellyfishin in 2009, and has since completed field-tests last year with success. This year, JEROS’s performance and speed has been improved with the ability to work in formation as a cooperative group to efficiently exterminate jellyfish. An unmanned aquatic robot JEROS with a mountable grinding part is buoyed by two cylindrical bodies that utilizes propulsion motors to move forward and reverse, as well as rotate 360 degrees. Furthermore, GIS (geographic information system)-based map data is used to specify the region for jellyfish extermination, which automatically calculates the path for the task. JEROS then navigates autonomously using a GPS (Global Positioning System) receiver and an INS(inertial navigation system). The assembly robots maintain a set formation pattern, while calculating its course to perform jellyfish extermination. The advantage of this method is that there is no need for individual control of the robots. Only the leader robot requires the calculated path, and the other robots can simply follow in a formation by exchanging their location information via wireless communication (ZigBee method). JEROS uses its propulsion speed to capture jellyfish into the grinding part on the bottom, which then suctions the jellyfish toward the propeller to be exterminated. The field test results show that three assembly robots operating at 4 knots (7.2km/h) disposes jellyfish at the rate of about 900kg/h. The research team has currently completed testing JEROS at Gyeongnam Masan Bay and is expected to further experiment and improve the performance at various environment and conditions. JEROS may also be utilized for other purposes including marine patrols, prevention of oil spills and waste removal in the sea. JEROS research has been funded by Ministry of Science, ICT and Future Planning and Ministry of Trade, Industry and Energy.
2013.09.27
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Transparent Glass Wall as a Touch Game Media
Professor Woo-hoon Lee - Selected as the “Highlight” at SIGGRAPH emerging technology conference - “An excellent example of the transparent display panel in everyday life” A joint research team led by KAIST Industrial Design Department’s Prof. Woo-hoon Lee and Computer Sciences Prof. Ki-hyuk Lee has developed a brand new concept game media “TransWall”, which utilizes both sides of the glass wall as the touch medium. TransWall has been chosen as the “highlight” of 2013 SIGGRAPH emerging technology conference. SIGGRAPH is a world-renowned conference in the area of computer graphics and interaction technique, last held 21st-25th July at Anaheim, in the United States. It all started with the thought, wouldn’t it be possible to turn the glass walls surrounding us into a medium for entertainment and communication? TransWall utilizes holographic screen film inserted between two glass sheets with a multi-touch function, onto which the image can be projected using the beam projector from both sides. Furthermore, an additional Surface Transducer attached to the glass can deliver the sound and vibration. What seemed as an ordinary glass wall has been transformed into a multi-sensory media that can transmit and receive visual, auditory and tactile information. TransWall can be implemented at public places such as theme parks, large shopping malls and subway stations, providing the citizens with a new form of entertainment. This touch-interaction method can also be applied to developing a variety of cultural contents in the future. Professor Lee said, “TransWall shows an example of near-future where touch-interaction method can be utilized with the soon-to-be commercialized transparent display panel in everyday lives.” TransWall Introduction video (https://vimeo.com/70391422) TransWall at SIGGRAPH 2013 Display (https://vimeo.com/71718874) Picture 1. Both sides of the glass wall can be used as a touch platform for various medias, including games. Picture 2. TransWall attracts the interests of the audience at SIGGRAPH emerging technology. Picture 3. Structure of TransWall Picture 4. Photo of TransWall from side
2013.09.19
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Secondary, High Capacity Battery developed from Rice Husks
Rice husks, a waste product from rice polishing, has been successfully utilized as the silicon anode for use in high capacity lithium ion secondary batteries. The new silicon anode derived from rice husks exhibit superior output and lifespan. Professor Choi Jang Wook (The Graduate School of Energy, Environment, Water and Sustainability (EEWS)) and Professor Park Seung Min (Department of Biochemistry) and their respective research teams separated naturally occurring, highly porous silica material within the rice husks and developed a 3-dimensional, highly porous silicon anode material. The result of the research effort was published in the online edition of the Proceedings of the National Academy of Sciences (PNAS) journal, a world renowned journal in the field of natural sciences. Silicon has attracted much attention as anode material for next generation lithium ion secondary batteries because it exhibits 3~5 times higher capacity than conventional graphene. The high capacity will pave the way to lithium secondary batteries with higher energy densities than conventional batteries. It is anticipated that the application of silicon batteries will yield electronic devices with a longer duration for use in addition to electronic vehicles boasting longer mileage. The silicon anode is based on the 3-dimensional, highly porous structure of rice husks which remedies the problematic extreme volume expansion of conventional silicon anodes. Utilization of inexpensive rice husks to create high value silicon anodes will cause a ripple effect on the industry and academia.
2013.08.23
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Ultra-High Strength Metamaterial Developed Using Graphene
New metamaterial has been developed, exhibiting hundreds of times greater strength than pure metals. Professor Seung Min, Han and Yoo Sung, Jeong (Graduate School of Energy, Environment, Water, and Sustainability (EEWS)) and Professor Seok Woo, Jeon (Department of Material Science and Engineering) have developed a composite nanomaterial. The nanomaterial consists of graphene inserted in copper and nickel and exhibits strengths 500 times and 180 times, respectively, greater than that of pure metals. The result of the research was published on the July 2nd online edition in Nature Communications journal. Graphene displays strengths 200 times greater than that of steel, is stretchable, and is flexible. The U.S. Army Armaments Research, Development and Engineering Center developed a graphene-metal nanomaterial but failed to drastically improve the strength of the material. To maximize the strength increased by the addition of graphene, the KAIST research team created a layered structure of metal and graphene. Using CVD (Chemical Vapor Deposition), the team grew a single layer of graphene on a metal deposited substrate and then deposited another metal layer. They repeated this process to produce a metal-graphene multilayer composite material, utilizing a single layer of graphene. Micro-compression tests within Transmission Electronic Microscope and Molecular Dynamics simulations effectively showed the strength enhancing effect and the dislocation movement in grain boundaries of graphene on an atomic level. The mechanical characteristics of the graphene layer within the metal-graphene composite material successfully blocked the dislocations and cracks from external damage from traveling inwards. Therefore the composite material displayed strength beyond conventional metal-metal multilayer materials. The copper-graphene multilayer material with an interplanar distance of 70nm exhibited 500 times greater (1.5GPa) strength than pure copper. Nickel-graphene multilayer material with an interplanar distance of 100nm showed 180 times greater (4.0GPa) strength than pure nickel. It was found that there is a clear relationship between the interplanar distance and the strength of the multilayer material. A smaller interplanar distance made the dislocation movement more difficult and therefore increased the strength of the material. Professor Han, who led the research, commented, “the result is astounding as 0.00004% in weight of graphene increased the strength of the materials by hundreds of times” and “improvements based on this success, especially mass production with roll-to-roll process or metal sintering process in the production of ultra-high strength, lightweight parts for automobile and spacecraft, may become possible.” In addition, Professor Han mentioned that “the new material can be applied to coating materials for nuclear reactor construction or other structural materials requiring high reliability.” The research project received support from National Research Foundation, Global Frontier Program, KAIST EEWS-KINC Program and KISTI Supercomputer and was a collaborative effort with KISTI (Korea Institute of Science and Technology Information), KBSI (Korea Basic Science Institute), Stanford University, and Columbia University. A schematic diagram shows the structure of metal-graphene multi-layers. The metal-graphene multi-layered composite materials, containing a single-layered graphene, block the dislocation movement of graphene layers, resulting in a greater strength in the materials.
2013.08.23
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Ultra High Speed Nanomaterial Synthesis Process Developed Using Laser
Dr. Jun-Yeop, Yeo and the research team led by Professor Seung-Hwan, Ko (both of the Department of Mechanical Engineering) successfully developed a process enabling the location-determinable, ultra high speed synthesis of nanomaterials using concentrated laser beams. The result of the research effort was published as the frontispiece in the July 9th issue of Advanced Functional Materials, a world renowned material science and engineering academic journal. Application of the technology reduced the time needed to process nanomaterial synthesis from a few hours to a mere five minutes. In addition, unlike conventional nanomaterial synthesis processes, it is simple enough to enable mass production and commercialization. Conventional processes require the high temperatures of 900~1,000 °C and the use of toxic or explosive vapors. Complex processes such as separation after synthesis and patterning are needed for application in electronic devices. The multi-step, expensive, environmentally unfriendly characteristics of nanomaterial synthesis served as road blocks to its mass production and commercialization. Exposing the precursor to concentrated continuous laser beam (green wavelength) resulted in the synthesis of nanowires in the desired location; the first instance in the world to accomplish this feat. The technology, according to the research team, makes possible the production, integration and patterning of nanomaterials using a single process. Applicable to various surfaces and substrates, nanowires have been successfully synthesized on flexible plastic substrates and controlled patterning on the surface of 3-dimensional structures. Dr. Yeo commented that the research effort has “yielded the creation of a nanomaterial synthesis process capable of synthesis, integration, pattern, and material production using light energy” and has “reduced the synthesis process time of nanomaterial to one tenths of the conventional process.” Dr. Yeo continues to devise steps to commercialize the new multifunctional electronic material and methods for mass production. The research effort, led by Dr. Yeo and Professor Ko, received contribution from Professor Hyung-Jin Sung (KAIST Department of Mechanical Engineering), Seok-Joon Hong, a Ph.D. candidate, Hyun-Wook Kang, also a Ph.D. candidate, Professor Costas Grigoropoulos of UC Berkeley, and Dr. Dae Ho Lee. In addition, the team received support from the National Research Foundation, Ministry of Knowledge Economy, Global Frontier Program, and KAIST EEWS. Picture I: Synthesized nanomaterials produced at a desirable location by laser beams Picture 2: Synthesized nanomaterials built on the 3D structure by using the developed technology Picture 3: Functional electric circuit made with synthesized nanomaterials Picture 4: Cover page of July 9th issue of Advanced Functional Materials
2013.08.23
View 9845
2013 International Conference for the Integration of Science, Technology, and Society at KAIST (ICISTS-KAIST)
The International Conference for the Integration of Science, Technology, and Society at KAIST (ICISTS-KAIST) is a global forum organized by KAIST undergraduate students to promote the exchange of ideas and facilitate the discussion of issues that are important to science, technology, society, and higher education. The ICISTS-KAIST conference has been held annually every summer since 2005, inviting distinguished speakers and guests from all around the world to share their insights and expertise with students gathered from Korea and abroad. Last year alone, more than 300 students from 22 nations and 40 speakers participated in the event. Originally, the ICISTS-KAIST was established by KAIST students who were inspired by the Harvard Project for Asian and International Relations (HPAIR), which is one of the Harvard’s largest annual student conferences in Asia. This year, 335 students from 103 universities in 22 countries joined the conference that was held on August 5th-9th in Daejeon, making the 2013 ICISTS-KAIST the biggest science and engineering gathering hosted by university students in Asia. About 36% of the participants were international students. The theme of the conference was “Perfect Alliance: Coexistence for Human Society,” in which students and speakers addressed issues on how to harmonize the speed of scientific progress with the development of important values in society, as well as to explore solutions to overcome the chasm, if any, between the boundaries of science and society. In his opening remarks, President Steve Kang said, “Creativity and innovation are born out of openness. Therefore, it is essential for young scientists and engineers to communicate with people from different cultural and political backgrounds. Through this kind of global interaction and exchange of ideas and views, students will have an opportunity to deepen their understanding of the world and to better examine the purpose of their intellectual exploration in science and technology.” At the 2013 ICISTS-KAIST, 25 distinguished speakers participated including Walter Bender, a former director of the Media Lab at MIT and David Christian, a professor of Macquarie University in Australia.
2013.08.08
View 10147
KAIST's wireless Online Electric Vehicle (OLEV) runs inner city roads
For the first time anywhere, electric buses provide public transportation services and are recharged right from the road. The Online Electric Vehicle (OLEV), developed by the Korea Advanced Institute of Science and Technology (KAIST), is an electric vehicle that can be charged while stationary or driving, thus removing the need to stop at a charging station. Likewise, an OLEV tram does not require pantographs to feed power from electric wires strung above the tram route. Following the development and operation of commercialized OLEV trams (at an amusement park in Seoul) and shuttle buses (at KAIST campus), respectively, the City of Gumi in South Korea, beginning on August 6th, is providing its citizens with OLEV public transportation services. Two OLEV buses will run an inner city route between Gumi Train Station and In-dong district, for a total of 24 km roundtrip. The bus will receive 20 kHz and 100 kW (136 horsepower) electricity at an 85% maximum power transmission efficiency rate while maintaining a 17cm air gap between the underbody of the vehicle and the road surface. OLEV is a groundbreaking technology that accelerates the development of purely electric vehicles as a viable option for future transportation systems, be they personal vehicles or public transit. This is accomplished by solving technological issues that limit the commercialization of electric vehicles such as price, weight, volume, driving distance, and lack of charging infrastructure. OLEV receives power wirelessly through the application of the “Shaped Magnetic Field in Resonance (SMFIR)” technology. SMFIR is a new technology introduced by KAIST that enables electric vehicles to transfer electricity wirelessly from the road surface while moving. Power comes from the electrical cables buried under the surface of the road, creating magnetic fields. There is a receiving device installed on the underbody of the OLEV that converts these fields into electricity. The length of power strips installed under the road is generally 5%-15% of the entire road, requiring only a few sections of the road to be rebuilt with the embedded cables. OLEV has a small battery (one-third of the size of the battery equipped with a regular electric car). The vehicle complies with the international electromagnetic fields (EMF) standards of 62.5 mG, within the margin of safety level necessary for human health. The road has a smart function as well, to distinguish OLEV buses from regular cars—the segment technology is employed to control the power supply by switching on the power strip when OLEV buses pass along, but switching it off for other vehicles, thereby preventing EMF exposure and standby power consumption. As of today, the SMFIR technology supplies 60 kHz and 180 kW of power remotely to transport vehicles at a stable, constant rate. Dong-Ho Cho, a professor of the electrical engineering and the director of the Center for Wireless Power Transfer Technology Business Development at KAIST, said: “It’s quite remarkable that we succeeded with the OLEV project so that buses are offering public transportation services to passengers. This is certainly a turning point for OLEV to become more commercialized and widely accepted for mass transportation in our daily living.” After the successful operation of the two OLEV buses by the end of this year, Gumi City plans to provide ten more such buses by 2015.
2013.08.07
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High Speed Nanomanufacturing Process Developed using Laser
Dr. Yeo Jun Yeop from KAIST’s Department of Mechanical Engineering, in a joint research project with Prof. Seung Hwan Ko, has developed a technology that speeds up the nanomanufacturing process by using lasers. Their research is published in the frontispiece of Advanced Functional Materials (July 9th issue). Fig. The frontispiece of Advanced Functional Materials(July 9th issue) The research group put a nanomaterial precursor on the board, illuminated it with a continuous-wave laser in the green wavelength range, and succeeded in synthesizing a nanowire at the point they wanted for the first time in the world. Currently nanomaterials are difficult to mass produce and commercialize due to their complex and costly manufacturing processes which also use toxic gases. However, their new technology simplified the process and so reduced the manufacturing time from some hours to five minutes (1/10th times reduced). Furthermore, this technology will apply regardless of the type of the board. Such nanometerials can be synthesized at any point on a flexible plastic board or even in three dimensional structures by illuminating them with a simple laser. Academics and industries expect mass production and commercialization of nanomaterials in near future. Dr. Yeo said he intends to research further to promote early commercialization of multifunctional electronic devices by combining various nanomaterials This research is sponsored by the National Research Foundation of Korea, the Ministry of Trade, Industry and Energy and KAIST EEWS Fig. A nanomaterial synthesized after illuminated by lasers Fig. A nanomaterial synthesized on a three dimensional structure using the developed technology Fig. Functional electron device manufactured by using the synthesized nanomaterials
2013.08.02
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KAIST and Seoul National University Agree to Expand Cooperation in Education and Research
The presidents of two top-notch universities in Korea, KAIST and Seoul National University (SNU), met on July 23rd at the SNU campus and agreed to expand their academic cooperation to promote the univresities" mutual development. To start, President Yeon-Cheon Oh of SNU proposed a student exchange program through which SNU students can take courses at KAIST for six months. In return, President Steve Kang suggested that KAIST establish a liaison office on the SNU campus to facilitate better communication between two universities, thereby developing more exchange programs for research and education.Additionally, the two public universities will set up a task force to implement the agreement, conduct joint research programs, and hold regular meetings between their faculty members.President Kang said, “SNU has superb academic and research programs not only in the fields of science and technology but also in the humanities, arts, and social sciences. KAIST will surely benefit from SNU’s excellence in a broad range of academic disciplines, and SNU will have an opportunity to capitalize on KAIST’s expertise in science, engineering, and technology to enhance its growth.”At the conclusion of their consultation, the presidents expressed the hope that the agreement will strengthen the two institutions" capacity for competitiveness and globalization, preparing them to compete with leading universities in the world.
2013.07.25
View 7774
A magnetic pen for smartphones adds another level of conveniences
Utilizing existing features on smartphones, the MagPen provides users with a compatible and simple input tool regardless of the type of phones they are using. A doctoral candidate at the Korea Advanced Institute of Science and Technology (KAIST) developed a magnetically driven pen interface that works both on and around mobile devices. This interface, called the MagPen, can be used for any type of smartphones and tablet computers so long as they have magnetometers embedded in. Advised by Professor Kwang-yun Wohn of the Graduate School of Culture Technology (GSCT) at KAIST, Sungjae Hwang, a Ph.D. student, created the MagPen in collaboration with Myung-Wook Ahn, a master"s student at the GSCT of KAIST, and Andrea Bianchi, a professor at Sungkyunkwan University. Almost all mobile devices today provide location-based services, and magnetometers are incorporated in the integrated circuits of smartphones or tablet PCs, functioning as compasses. Taking advantage of built-in magnetometers, Hwang"s team came up with a technology that enabled an input tool for mobile devices such as a capacitive stylus pen to interact more sensitively and effectively with the devices" touch screen. Text and command entered by a stylus pen are expressed better on the screen of mobile devices than those done by human fingers. The MagPen utilizes magnetometers equipped with smartphones, thus there is no need to build an additional sensing panel for a touchscreen as well as circuits, communication modules, or batteries for the pen. With an application installed on smartphones, it senses and analyzes the magnetic field produced by a permanent magnet embedded in a standard capacitive stylus pen. Sungjae Hwang said, "Our technology is eco-friendly and very affordable because we are able to improve the expressiveness of the stylus pen without requiring additional hardware beyond those already installed on the current mobile devices. The technology allows smartphone users to enjoy added convenience while no wastes generated." The MagPen detects the direction at which a stylus pen is pointing; selects colors by dragging the pen across smartphone bezel; identifies pens with different magnetic properties; recognizes pen-spinning gestures; and estimates the finger pressure applied to the pen. Notably, with its spinning motion, the MagPen expands the scope of input gestures recognized by a stylus pen beyond its existing vocabularies of gestures and techniques such as titling, hovering, and varying pressures. The tip of the pen switches from a pointer to an eraser and vice versa when spinning. Or, it can choose the thickness of the lines drawn on a screen by spinning. "It"s quite remarkable to see that the MagPen can understand spinning motion. It"s like the pen changes its living environment from two dimensions to three dimensions. This is the most creative characteristic of our technology," added Sungjae Hwang. Hwang"s initial research result was first presented at the International Conference on Intelligent User Interfaces organized by the Association for Computing Machinery and held on March 19-22 in Santa Monica, the US. In the next month of August, the research team will present a paper on the MagPen technology, entitled "MagPen: Magnetically Driven Pen Interaction On and Around Conventional Smartphones" and receive an Honorable Mention Award at the 15th International Conference on Human-Computer Interaction with Mobile Devices and Services (MobileHCI 2013) to be held in Germany. In addition to the MagPen, Hwang and his team are conducting other projects to develop different types of magnetic gadgets (collectively called "MagGetz") that include the Magnetic Marionette, a magnetic cover for a smartphone, which offers augmented interactions with the phone, as well as magnetic widgets such as buttons and toggle interface. Hwang has filed ten patents for the MagGetz technology. Youtube Links: http://www.youtube.com/watch?v=NkPo2las7wc, http://www.youtube.com/watch?v=J9GtgyzoZmM
2013.07.25
View 10470
Chin-Wan Chung, a professor of computer science, received the best paper award from ACM
The Korea Times reported on July 12, 2013 that Chin-Wan Chung, a professor of computer science at KAIST, won the best paper award by the Association for Computing Machinery (ACM). For the article, please click the link: http://koreatimes.co.kr/www/news/people/2013/07/178_139132.html
2013.07.15
View 6947
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