TR
-
Prof. Cho Identifies Dynamics of Signal Transportation System in Control of Cell Proliferation
KAIST, Jan. 22, 2009 -- A research team led by Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has identified a hidden mechanism of the dynamic behavior of signal transportation system involved in the control of cell proliferation, university authorities said.
The finding is expected to provide a clue to appropriately controlling the pathway of ERK protein which is known to play a significant role in causing and spreading cancer. The research was featured as the cover paper of the latest online edition of the Journal of Cell Science.
The Ras-Raf-MEK-ERK pathway (or ERK pathway) is an important signal transduction system involved in the control of cell proliferation, survival and differentiation. However, the dynamic regulation of the pathway by positive- and negative-feedback mechanism, in particular the functional role of Raf kinase inhibitor protein (RKIP) are still incompletely understood. RKIP is a physiological endogenous inhibitor of MEK phosphorylation by Raf kinases, but also participates in a positive-feedback loop in which ERK can inactivate RKIP.
"We attempted to unearth the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and computer simulations based on an experimentally validated mechanical model," Prof. Cho was quoted as saying.
2009.02.03 View 12452 -
Six Organizations Join Forces to Induce Projected National Brain Institute to Daejeon
Six major organizations including KAIST have joined forces to help Daejeon City to win the government approval to build the envisioned Korean Brain Institute in Daedeok Research Complex.
The six organizations signed a memorandum of understanding on cooperating in establishing the government-funded institute built within the Daedeok Research Complex in the city of Daejeon, at KAIST on Jan. 14. The six organizations are KAIST, the Daejeon City Government, Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Standard and Science, Asan Medical Center, and SK Corp., a pioneer in effective therapeutic invention for serious brain disorders.
The partnership of the six organizations is expected to bring a broad-based cooperation opportunities and create a massive synergy effect in the brain science researches and the development of new therapeutic treatment for brain disorders by combining their resources and infrastructures.
The six organizations have also built an international research network with such globally-renowned brain research institutions as RIKEN, a large natural sciences research institute in Japan, Max Plank Institute in Germany, Federal Institute of Technology, Lausanne, in Switzerland and Brain Research Institute of University of Queensland in Australia. The research network is under the support and guidance of Dennis Choi, a prominent neuroscientist who once served as the President of the Society for Neuroscience and is currently a professor in the Departments of Neurology and biology at Emory University.
The tentatively titled Korea Brain Institute is envisioned to help fight brain disorders and create Korea"s new growth engine, as well as lengthening life span, by conducting convergence researches in nero science, brain science and pharmacology. If the consortium of the six organizations wins the government approval to build the proposed institute within the Daedeok complex, the central government and the Daejeon city government are expected to pour a total of 329.7 billion won into the project by 2020.
2009.01.14 View 17980 -
Five KAIST Students Offered Internship from Qualcomm
Qualcomm Inc., a wireless telecommunications research and development company based in San Diego, California, has offered internship for five KAIST students of the Department of Electrical Engineering and Computer Science, university authorities said on Monday (Jan. 5).
The five students who are graduate and doctoral students studying communication and RFID (radio frequency identification) design will be working for six months at Qualcomm"s RFIC (radio frequency integrated circuits) Department in Santa Clara, Calif., as co-researchers. These interns will receive about $7,000 a month each with other benefits.
It is the first time that Qualcomm has offered internship for students outside the U.S., according to external relations officials at KAIST. Students who have shown outstanding research output during the internship period will be offered employment at Qualcomm.
"Qualcomm"s internship for KAIST students is designed to help young Korean talents to become professionals who will lead global advancement in the IT sector and strengthen its research network with Korea," Seung-Soo Kim, senior director of Qualcomm Korea, was quoted as saying.
Qualcomm plans to continue providing internship program for KAIST students, as well as pursuing joint research initiatives, the officials said.
2009.01.08 View 15889 -
Prof. Seong Publishes English Book on Reliability in Digital Control Systems
Prof. Poong-Hyun Seong of Department of Nuclear and Quantum Engineering has recently published an English-language book on reliability and risk issues in large scale safety-critical digital control systems used in complex facilities such as nuclear power plants.
The book entitled “Reliability and Risk Issues in Large Scale Safety-critical Digital Control Systems” is a result of Prof. Seong’s collaboration with some KAIST graduates who used to be under his guidance. The 303-page publication has been published by Springer, one of the world’s leading publishers of academic journals, as part of the Springer Series in Reliability Engineering.
The book consists of four parts; part I deals with issues related to hardware, part II software, part III human factors and finally the last part integrated systems. It can be purchased through some on-line book stores such as Amazon.com.
Prof. Seong served as an editor-in-chief for Nuclear Engineering and Technology (NET), an international journal of Korean Nuclear Society (KNS), from 2003 to 2008. He also worked as a chair of the Human Factors Division (HFD) of American Nuclear Society (ANS) from 2006 to 2007. Prof. Seong is now a commissioner of Korea Nuclear Safety Commission which is the nation’s highest committee on Nuclear Safety.
2008.12.26 View 17097
-
KAIST Scientists Creates Transparent Memory Chip
--See-Through Semis Could Revolutionize Displays
A group of KAIST scientists led by Prof. Jae-Woo Park and Koeng-Su Lim has created a working computer chip that is almost completely clear -- the first of its kind.
The new chip, called "transparent resistive random access memory (TRRAM), is similar in type to an existing technology known as complementary metal-oxide semiconductor (CMOS) memory -- common commercial chips that provide the data storage for USB flash drives and other devices. Like CMOS devices, the new chip provides "non-volatile" memory, meaning that it stores digital information without losing data when it is powered off. Unlike CMOS devices, however, the new TRRAM chip is almost completely clear.
The paper on the new technology, entitled "Transparent resistive random access memory and its characteristics for non-volatile resistive switching," was published in the December issue of the Applied Physics Letters (APL), and the American Institute of Physics, the publisher of APL, issued a press release about this breakthrough.
"It is a new milestone of transparent electronic systems," says researcher Jung-Won Seo, who is the first author of the paper. "By integrating TRRAM devices with other transparent electronic components, we can create a totally see-through embedded electronic system."
Technically, TRRAM devices rely upon an existing technology known as resistive random access memory (RRAM), which is already in commercial development for future electronic data storage devices. RRAM is built using metal oxide materials between equally transparent electrodes and substrates.
According to the research team, TRRAM devices are easy to fabricate and may be commercially available in just 3-4 years.
"We are sure that TRRAM will become one of alternative devices to current CMOS-based flash memory in the near future after its reliability is proven and once any manufacturing issues are solved," says Prof. Jae-Woo Park, who is the co-author on the paper. He adds that the new devices have the potential to be manufactured cheaply because any transparent materials can be utilized as substrate and electrode. They also may not require incorporating rare elements such as Indium.
2008.12.17 View 17517 -
Prof. Cho Wins Best Paper Award
KAIST Prof. Nam-Zin Cho of the Department of Nuclear and Quantum Engineering, won the Best Thesis Award in the nuclear reactor physics category at the 2008 Winter Meeting of the American Nuclear Society held on Nov. 9-13 in Reno, Nevada.
His paper, entitled "Thermal Feedback Transient Analysis of a Pebble Fuel Based on the Two-Temperature Homogenized Model," was jointly authored by Hwi Yu and Jong-Un Kim under the guidance of Prof. Cho.
Prof. Cho was elected a fellow of the American Nuclear Society in 2001 and has served as the deputy editor of the Nuclear Science and Engineering, the research journal of the American Nuclear Society, since 1999.
2008.12.09 View 15016 -
2008 IEEE International Conference on Humanoid Robots Opens
The 2008 IEEE-RAS International Conference on Humanoid Robots, an international gathering to identify new research trends and technology in humanoid robotics, will open a three-day session on Monday (Dec. 1) at the Hotel Rivera and KAIST in Daejeon.
The annual conference is organized by KAIST and the Robotics and Automation Society of the Institute for Electric and Electronic Engineers, a U.S.-based international non-profit, professional organization for the advancement of technology related to electricity.
The conference is expected to draw a total of 200 robotics researchers from 19 different countries. Prof. Jun-Ho Oh, at the Department of Mechanical Engineering who led the creation of Korea"s first humanoid robot Hubo, is serving as general chair of the conference. Prof. Oh was named the host of the 2008 conference at the 2007 conference held at the Carnegie Melon University of the United States. The eight-year old conference was inaugurated in Boston in 2000.
On the opening day of Dec. 1, seven lectures will be given on diverse areas of robotics including cognitive humanoid vision, and robot vision sensor and sensing. On the subsequent two days, a total of 110 papers will be presented.
During the conference period, a variety of robots produced by six local and foreign robot makers will be on demonstration, providing opportunities for researchers and industrial robot makers to share technological ideas.
Highlights of the conference will be special lectures by world-renowned robot researchers Prof. Yoshiyuki Sankai of University of Tsukuba, who has created an exoskeletal "robot suit," and Prof. Art Kuo of Univerity of Michigan who is regarded as a leading authority in dynamic walking.
Following the conference, all participants are scheduled to tour Prof. Oh"s Hubo Lab and the Human-Robot Interaction Research Center, both located at KAIST.
2008.12.01 View 14840
-
Method to Synthesize New Lithium Ion Battery Cathode Material Identified
A KAIST research team headed by Prof. Do-Kyung Kim at the Department of Materials Science and Engineering developed a technology to synthesize a new lithium ion battery spinel cathode which is regarded as a core part of hybrid and lithium battery cars.
The research was conducted in collaboration with a research team of Prof. Yi Cui at Stanford University"s Department of Chemistry. Their findings were introduced in the November issue of Nano Letters, one of the leading academic journals in nano-science.
The newly synthesized lithium ion battery spinel cathode known as spinel LiMn2O4 nanorods is attracting interests as an alternative cathode material since it is a low-cost, environmentally friendly substance for Li-ion battery cathodes. Its raw material is also highly available.
Lithium ion batteries with high energy and power density are important for consumer electronic devices, portable power tools, and vehicle electrification. LixCoO2 is a commonly used cathode material in commercial lithium iron batteries. However, the high cost, toxicity, and limited abundance of cobalt have been recognized to be disadvantageous.
2008.11.20 View 13156 -
KAIST Opens Cell Bench Research Center
KAIST opened a cell bench research center on the campus on Monday, Nov. 17, as a joint project with Samsung Electric Co. and Samsung Medical Center.
On hand at the opening ceremony were about 100 persons from the three organizations, including KAIST President Nam-Pyo Suh, Samsung Electric"s Chief Technology Officer (CTO) Byung-Cheon Koh and Samsung Medical Center Vice President Hyo-Geun Lim.
The newly-opened research center will be involved in the development of individually-tailored anti-cancer medicine using bio-inspired cell chips and technologies for clinical applications. Prof. Young-Ho Cho of the Department of Bio and Brain Engineering was named director of the research center.
"Top-notch professionals from the electronic industry, academia and the medical community have gathered together to establish this research center. We expect the center will open a new path for the science and technology community and the industry to combine their strengths and develop innovative anti-cancer therapeutics," said KAIST President Nam-Pyo Suh at the opening ceremony.
"The development of bio-cell chip technology represents a new challenge for the Samsung Electric which has focused on information technologies thus far. Through cooperation with KAIST and Samsung Medical Center, we expect to be able to develop a simple and efficient cure for cancer patients," commented Samsung Electric CTO Byung-Cheon Koh.
The research center will be initially concentrating on the development of cell chips for lung cancer, one of the primary causes of death for Koreans.
2008.11.17 View 16604 -
KAIST Research Team Unveils Method to Fabricate Photonic Janus Balls
A research team led by Prof. Seung-Man Yang of the Department of Chemical and Biomolecular Engineering has found a method to fabricate photonic Janus balls with isotropic structural colors.
The finding draws attention since the newly-fabricated photonic balls may prove useful pigments for the realization of e-paper or flexible electronic displays.
The breakthrough was published in the Nov. 3 edition of the science journal "Advanced Materials." The Nov. 6 issue of "Nature" also featured it as one of the research highlights under the title of "Future Pixels."
Prof. Yang"s research team found that tiny marbles, black on one side and colored on the other, can be made by "curing" suspensions of silica particles with an ultraviolet lamp. When an electric field is applied, the marbles line up so that the black sides all face upwards, which suggests they may prove useful pigments for flexible electronic displays.
The researchers suspended a flow of carbon-black particles mixed with silica and a transparent or colored silica flow in a resin that polymerizes under ultraviolet light. They then passed the mixture through a tiny see-through tube. The light solidified the silica and resin as balls with differently colored regions, each about 200 micrometers in diameter.
Over the last decades, the development of industrial platforms to artificially fabricate structural color pigments has been a pressing issue in the research areas of materials science and optics. Prof. Yang, who is also the director of the National Creative Research Initiative Center for Integrated Optofluidic Systems, has led the researches focused on fabrication of functional nano-materials through the process of assembling nano-building blocks into designed patterns.
The "complementary hybridization of optical and fluidic devices for integrated optofluidic systems" research was supported by a grant from the Creative Research Initiative Program of the Ministry of Education, Science & Technology.
2008.11.12 View 14674 -
KAIST, KRIBB Agree to Cooperate in Research of Convergence Technologies
Oct. 15, 2008 -- KAIST and Korea Research Institute of Bioscience and Biotechnology (KRIBB) have agreed to cooperate in the research of convergence fields of biotechnology, information technology and nanotechnology.
To this end, the two institutions concluded a memorandum of understanding to create a new academia-institute cooperative model in the convergence fields on Oct. 15 in Seoul, with KAIST President Nam-Pyo Suh, KRIBB Director Young-Hoon Park and Vice Minister of Education, Science and Technology Jong-Koo Park in attendance.
Under the agreement, the two institutions will set up the tentatively-named KAIST-KRIBB BINT Convergence Institute for the development of technologies and nurturing skilled manpower in the convergence fields.
The partnership of the two institutions is expected to bring broad-based cooperation opportunities and create a massive synergy effect by combining their resources and infrastructure for the development of convergence technologies, KAIST officials said..
The proposed institute is also designed to build a world-class research hub in systems biotechnology by combining strengths of the two institutions with initiatives to achieve the Korean government"s new vision for "low carbon, green growth."
The institute will also serve as a base for domestic brain convergence by concentrating the nation"s research capacities in genetics and brain technology.
KAIST also signed a memorandum of understanding for cooperation in researches in Oriental medicine with three institutions, KRIBB, Daegu Hanny University and Korea Institute of Oriental Medicine.
The agreement calls for the four institutions to conduct joint researches in traditional sciences and Oriental medicine based on systems biology, develop manpower in related fields and share academic and research information.
The agreement is expected to provide impetus to reinforcing competitiveness in compound and convergence technologies and discover new properties in Oriental medicine, according to KAIST authorities.
2008.10.16 View 16658 -
KAIST Professor Exposes Structural Dynamics of Protein in Solution
-- Dr. Hyot-Cherl Ihee"s 3-Year Research Is Valuable in Pharmaceutical Application
Prof. Hyot-Cherl Ihee and his team at the Department of Chemistry, KAIST, has successfully unveiled the structural dynamics of protein in solution as a result of more than three years" research work.
Nature Methods, a sister publication of the authoritative science magazine Nature, published the treatise, titled "Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering" in its Sept. 22 online edition. The research paper will be carried in the magazine"s printed version in its October edition, according to Dr. Lee who is its correspondence author.
In May 2005, Prof. Ihee successfully photographed the structural dynamics of protein in solid state and his findings were published in the Proceedings of National Academy of Science of the United States. As protein normally exists in human body in solution, not in solid state, he directed his research to developing the technology to capture protein"s dynamics in resolved state.
In July that year, Prof. Ihee succeeded in measuring the structural changes of simple organic molecules in real time. He further developed the technology to uncover the structural dynamics of hemoglobin, myoglobin and cytochrome C.
Prof. Ihee"s research, helped with the Education-Science-Technology Ministry"s Creative Research Promotion Fund, can be applied to new pharmaceutical development projects as well as nanotechnology development, according to KAIST officials.
Prof. Ihee who earned his doctorate at California Institute of Technology in 1994 began teaching at KAIST in 2003. He won the Young Scientist Award given by the Korean government in 2006.
2008.09.22 View 14037