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The hereditary factor of autism revealed
Korean researchers have successfully investigated the causes and hereditary factors for autistic behavior and proposed a new treatment method with fewer side effects.
This research was jointly supported by the Ministry of Education, Science and Technology and the National Research Foundation as part of the Leading Researcher and Science Research Center Program
The research findings were publishing in the June edition of Nature magazine and will also be introduced in the July edition of Nature Reviews Drug Discovery, under the title ‘Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function’.
The research team found that lack of Shank2 genes in mice, which are responsible for the production of synapse proteins, caused autistic-like behavior. The results strongly suggested that the Shank2 gene was linked to autistic behavior and that Shank2 deficiency induced autistic behaviors.
Autism is a neural development disorder characterized by impaired social interaction, repetitive behavior, mental retardation, anxiety and hyperactivity. Around 100 million people worldwide display symptoms of autistic behavior. Recent studies conducted by the University of Washington revealed that 1 out of 3 young adults who display autistic behavior do not fit into the workplace or get accepted to college, a much higher rate than any other disorder. However, an effective cure has not yet been developed and current treatments are limited to reducing repetitive behavior.
The research team confirmed autistic-like social behavior in mice without the Shank2 genes and that the mice had decreased levels of neurotransmission in the NMDA receptor. The mice also showed damaged synaptic plasticity* in the hippocampus**.
* Plasticity: ability of the connectionbetween two neurons to change in strength in response to transmission of information
**Hippocampus: part of the brain responsible for short-term and long-term memory as well as spatial navigation.
The research team also found out that, to restore the function of the NMDA receptor, the passive stimulation of certain receptors, such as the mGLuR5, yielded better treatment results than the direct stimulation of the NMDA. This greatly reduces the side effects associated with the direct stimulation of receptors, resulting in a more effective treatment method.
This research successfully investigated the function of the Shank2 gene in the nerve tissue and showed how the reduced function of the NMDA receptor, due to the lack of the gene, resulted in autistic behavior. It also provided new possibilities for the treatment of autistic behavior and impaired social interaction
2012.06.24 View 10896 -
ICISTS-KAIST: Korea's Largest Scale University Student International Conference
An entirely student led and planned international conference will be held at KAIST.
KAIST student club ICISTS will be holding the ‘ICISTS-KAIST 2012’ conference from the 6th of August till the 10th of August.
This is the 8th annual conference which started in 2005 which is planned and executed entirely by undergraduate students. The conference aims at examining the rapidly changing relationship between science and technology and society and actively debate on the matter.
The 1st conference involved only 150 students of which only a few from abroad. However last year’s conference involved 300 students from 22 nations from all over the world.
The keyword of the conference in the much talked about ‘integration’ and therefore aims at establishing interdisciplinary networks that go beyond background and borders.
Not only does ‘ICISTS-KAIST’ involves panel talks by speakers, but also offers small scale lectures simultaneously which allows participants to attend talks that suit their individual preferences.
Group discussion session between participants and speakers will be held along with various performances and booths to introduce Korean traditional culture to international participants.
The theme of this year’s conference is “Age of Integration: Beyond the Borders of Knowledge”. It is comprised of 3 smaller conferences with themes of Art and Science, Natural Sciences and Social Sciences, and Science and Technology and Human Society.
This year’s conference will host lectures by Professor S. Shyam Sundar of Pennsylvania State Communication University, Professor Bruce E. Seely Dean of Michigan School of Engineering, and Professor Shin Hui Seop who was named as the ‘1st National Scientist’ in 2005.
Registration ends on the 15th of July and more information can be found at www.icists.org.
2012.06.18 View 8073
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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers.
*Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes.
Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions).
Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease.
Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease.
Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases.
However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself.
Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases.
The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases.
It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems.
The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30 View 11801
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Biomimetic reflective display technology developed
Professor Shin Jung Hoon
The bright colors of a rainbow or a peacock are produced by the reflection and interference of light in transparent periodic structures, producing what is called a structural color. These colors are very bright and change according to the viewing angle. On the other hand, the wings of a morpho-butterfly also have structural colors but are predominantly blue over a wide range of angles. This is because the unique structure of the morpho-butterfly’s wings contains both order and chaos.
Professor Shin Jung Hoon’s team from the Department of Physics and the Graduate School of Nanoscience and Technology at KAIST produced a display that mimics the structure of the morpho-butterfly’s wings using glass beads.
This research successfully produced a reflective display (one that reflects external light to project images), which could be used to make very bright displays with low energy consumption. This technology can also be used to make anti-counterfeit bills, as well as coating materials for mobile phones and wallets.
The structure of the morpho-butterfly’s wings seems to be in periodic order at the 1-micrometer level, but contains disorder at the 100-nanometer level. So far, no one had succeeded in reproducing a structure with both order and disorder at the nanometer level.
Professor Shin’s team randomly aligned differently sized glass beads of a few hundred nanometers to create chaos and placed a thin periodic film on top of it using the semiconductor deposition method, thereby creating the morpho-butterfly-like structure over a large area.
This new development produced better color and brightness than the morpho-butterfly wing and even exhibited less color change according to angle. The team sealed the film in thin plastic, which helped to maintain the superior properties whilst making it more firm and paper-like.
Professor Shin emphasized that the results were an exemplary success in the field of biomimetics and that structural colors could have other applications in sensors and fashion, for example.
The results were first introduced on May 3rd in Nature as one of the Research Highlights and will be published in the online version of the material science magazine, Advanced Materials.
This research was jointly conducted by Professor Shin Jung Hoon (Department of Physics / Graduate School of Nanoscience and Technology at KAIST), Professor Park NamKyoo (Department of Electrical and Computer Engineering at Seoul National University), and Samsung Advanced Institute of Technology. The funding was provided by the National Research Foundation of Korea and the Ministry of Education, Science and Technology as part of the World Class University (WCU) project.
Figure 2. The biomimetic film can express many different colors
Figure 3. The biomimetic diplay and a morpho-butterfly
2012.05.07 View 13470 -
10 Technolgies to Change the World in 2012: The Future Technology Global Agenda Council
The Future Technology Global Agenda Council which is under the World Economy Forum and which KAIST’s biochemical engineering department’s Prof. Sang Yeob Lee is the head of, chose the 10 new technologies that will change the world in year 2012.
The ten technologies include: IT, synthetic biology and metabolic engineering, Green Revolution 2.0, material construction nanotechnology, systematic biology and the simulation technology of biological systems, the technology to use CO2 as a natural resource, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology.
The technologies were chosen on the basis of the opinions various science, industry, and government specialists and is deemed to have high potential to change the world in the near future.
The Future Technology Global Agenda Council will choose ten new technologies yearly starting this year in order to solve the problems the world now faces.
The informatics systems that was ranked 1st place, sifts only the data necessary for decision making out of the overflowing amount of data. Much interest has been spurred at the Davos forum.
The synthetic biology and metabolic engineering chosen is expected to play an important role in creating new medicines and producing chemical substances and materials from reusable resources.
Biomass has also been chosen as one of the top ten most important technologies as it was seen to be necessary to lead the second Green Revolution in order to stably provide food for the increasing population and to create bio refineries.
Nanomaterials structured at the molecular level are expected to help us solve problems regarding energy, food, and resources.
Systematic biology and computer modeling is gaining importance in availing humans to construct efficient remedies, materials, and processes while causing minimum effects on the environment, resource reserves, and other people.
The technology to convert CO2, which is considered a problem all over the world, into a useful resource is also gaining the spotlight
Together with such technologies, wireless power transmission technology, high density energy power system, personalized medical/nutritional/disease preventing system, and new education technology are also considered the top ten technologies to change the world.
Prof. Lee said, “Many new discoveries are being made due to the accelerating rate of technological advancements. Many of the technologies that the council has found are sustainable and important for the construction of our future.”
2012.04.04 View 10332
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KAIST placed the 5th in top 50 global universities for international patent applications
New York Times released an article, dated March 19, 2012, on the statistics of international patent applications filed by global universities during 2011, and with 103 applications published, KAIST was listed the fifth among the top 50 universities, right behind four US universities: University of California (277), the Massachusetts Institute of Technology (179), the University of Texas System (127), and Johns Hopkins University (111). A total of seven Korean universities including KAIST made the top 50 list. For the article, please check the link below:
New York Times, March 19, 2012
“U.S. Universities Retain Lead in Patent Applications”
By Christopher F. Schuetze
http://www.nytimes.com/2012/03/19/world/asia/us-universities-retain-lead-in-patent-applications.html
In addition, for the press release by the World Intellectual Property Organization, the UN agency responsible for the Patent Cooperation Treaty, on international patent filings in 2011, please click the following link:
“International Patent Filings Set new Record in 2011”
http://www.wipo.int/pressroom/en/articles/2012/article_0001.html
2012.03.21 View 9110
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Distinguished Professor Sang-Yeop Lee gave keynote speech in '2011 China Bio-Refinery Summit'
Distinguished Professor Sang-Yeop Lee gave keynote speech in ‘2011 China Bio-Refinery Summit’ held in Chang’an, Beijing
Professor Lee gave a lecture on the vitalization strategy of ‘Bio-Refinery’, which is ‘A bio-based chemical industry to replace fossil fuel-based petro chemistry.
Professor Lee, insisted that for the successful construction of ‘Bio-Refinery’, there should be innovation in all value chain of biomass; biomass producer, bio-refinery business, consumer, government, etc. ▲Securement and distribution of Biomass ▲Development of strain and process for fermentation separation to effectively change biomass into chemical substance and fuel ▲Optimization of transportation and marketing.
During this summit, high-ranking government officials in politics and economics, executives of multicultural and Chinese business participated. From Korea, Do-Young Seung of Manager of technology research of GS and Hang-Deok Roh of laboratory chief of SK Chemical participated as panelist.
World Economy Forum, the gathering of leaders and experts in politics, economics, and policy created a ‘Global Agenda Council’ to find solutions on the issue of ‘sustainable growth of environment of the Earth and humanity’. Professor Lee is the chairperson of ‘Emerging Technologies Global Agenda Council (GAC)’ of Word Economy Forum.
Professor Lee, founder of ‘Systems Metabolic Engineering’, has made remarkable achievements world-wide, including a technology that manipulates metabolic circuit of microorganisms to purify various crude-originated chemical substances into environmentally friendly substances.
Currently, he is working on Systems biology research business in Ministry of Education, Science and Technology, Global Frontier Biomass business, Global Frontier Intelligent Bio-system construction and composition, to make progress in metabolic engineering which is essential for the bio-chemical industry.
2012.03.06 View 10921
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A Step Closer to Ultra Slim Mobile Phone
Professor Baek Kyung Wook (department of Material Science and Engineering) succeeded in developing an ultra-thin conjugation technique that can perfectly replace the modular contact in electronic devices.
The research team developed a compound material using ultra-fine solder-adhesive film and developed the vertical ultrasonic conjugation process thereby making a reliable utra-thin conjugation.
The developed technique allowed for very thin and reliable conjugation and will be able to replace the socket type connector and is expected to revolutionize the electronic device industry.
In mobile electronic devices like the smartphone, the trend is to incorporate various functional modules like camera, display, touchscreens, etc. in addition to striving for miniaturization of the device.
Recently the problem was the fact that the number of modules within the device was increasing due to the incorporation of various functions, and consequently the volume that these modules took up increased as well, which made miniaturization almost impossible.
Professor Baek‘s team succeeded in improving upon this problem by creating a compound material that has ultra-fine solder particles that can melt to form alloy fusion with the electrode and thermosetting adhesive film that can wrap around the electrode and provide mechanical protection.
The use of this material made it possible to reduce the thickness of the connector by hundredth fold which improved electrical, mechanical properties and highly reliable.
From a processing standpoint the conventional conjugation process involved heating the mechanical block and was therefore hard to manage its production and also consumed 1000W and took up to 15 seconds.
By contrast, Professor Baek’s team’s new process uses only ultrasound to locally heat and melt the conjugation point itself thereby reducing power consumption to 100W and conjugation time to 1~5 seconds.
The technique developed by Professor Baek and Lee Ki Won Doctorate student was awarded Excellent Dissertation Award by world famous journals like the Electronic Components and Technology Conference and is being recognized worldwide.
2012.01.31 View 8899
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Great Success!: 2011 Wearable Computer Contest
The 2011 Wearable Computer Contest (WCC) was held on the 28th and 29th of November at Seoul COEX. The WCC is hosted by KAIST and Korea Next Generation Computing Society and is an annual event.
A wearable computer allows the user to freely use the computer even a moving environment and involves the miniaturization, weight lightening to incorporate the computer into clothing. It is the fusion of IT technology and fashion and is opening new fields like entertainment, healthcare and other forms of fashion culture.
The competition selected 10 teams out of the 57 teams that applied that will participate in the finals.
The selected teams have to use smartphones to create a wearable computer that detects and uses the biorhythm of the wearer. A staff member commented that the requirement to use biorhythm reflected in many teams entering products related to health and safety, and body and entertainment.
The most notable of the products entered was the outfit that prevents bicycle accidents. The LED attached on the back shows the direction the bicycle is traveling, or if it is stopping and uses the smartphone as a camera to show the cyclist what’s going on behind him.
Other interesting products included a product that turned clothes into a movie theater. Whilst watching movies on the smartphone, sensors attached to the clothing give out vibrations, water vapor, smoke effect; essentially brining the 4D movie experience to each person.
In addition products like ▲LED jacket that turns music into light and vibration ▲a prosthetic arm using an electromyogram to move it ▲an exercise suit that detects regional exercise load and helps design a balanced exercise regime.
Kolon Industries Ltd. Provide the clothing for the finalists and the team that receives Kolon Special Award will be given the opportunity to commercialize the product.
2012.01.31 View 8097
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Professor Jang Soon Heung Appointed International Consultant of the Fukushima Nuclear Disaster Task Force
The Japanese government appointed Professor Jang Soon Heung (department of Nuclear and Quantum Engineering) as the International Consultant to the Fukushima Nuclear Disaster Task Force.
Professor Hatamura Yotaro of the Tokyo University is the head of the task force and is tasked with finding out the cause and extent of damage of the disaster and minimize social cost and expansion of damage along with prevent a similar disaster from occurring.
The International Consultants will independently advise and look over the findings of the task force.
The members include: Professor Jang Soon Heung (Professor of KAIST), Richard A. Meserve (Carnegie Research Center Director/Former Chairman of Nuclear Regulatory Commission), Andre-Claude Lacoste (Chairman of French Nuclear Safety Regulatory Commission), and Lars-Eirk Holm (Secretary General of Sweden Health and Welfare).
2012.01.31 View 7920
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 8840
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2011 IT Convergence International Workshop
KAIST held the 2011 IT Convergence International Workshop on Future Mobile Service & Service Technology.
The workshop was attended by Kim Byoung Il (Chairman of National Science and Technology Commission), Koichi Asatani (Professor at Kogakuin University), Jay H. Eum (representative of TransLink Capital), among 15 other experts from government, scholar, industry, and IT defense.
The keynote speaker, Chairman Kim Byoung Il, gave a speech on Industry Development Strategy for Software. Professor Koichi Asatani gave a presentation on information communication technology and future trend of future network and service. And Jay H. Eum will be giving a presentation on the technological venture firm strategy that was so successful in Silicon Valley.
There will be presentations and debate on mobile services, IT security and defense, IT convergence technology, software technology and other future IT convergence technologies.
2012.01.31 View 7058