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KAIST's Partnership Agreement with the Imperial College of Science, Technology and Medicine, UK
KAIST signed an agreement on academic and research cooperation with the Imperial College of Science, Technology (Imperial College London) and Medicine in the United Kingdom (UK) on November 6th, 2013 in London.
The two universities have been implementing collaboration programs at the department level in the areas of plastic electronics since September 2012 and systems engineering and molecular simulation since February 2013, but have never had a formal partnership agreement.
President Steve Kang from KAIST and Provost James Stirling from Imperial College London signed the comprehensive cooperation agreement which will not only strengthen the existing collaborations between the two institutions but also explore areas of mutual interest in the interdisciplinary study of big data, as well as in the fields of mechanical engineering, synthetic biology, and quantum physics.
Workshops, seminars, lectures, and conferences will be jointly organized and held to facilitate the exchange of research staff and faculty and to promote collaborations in research assignments. The universities will also look into the possibility of exchange programs for undergraduate and graduate students.
The partnership agreement will be effective for five years.
Minister Moon-Gi Choi from the Republic of Korea’s Ministry of Science, Information and Communications Technology (ICT) & Future Planning attended the signing ceremony as well and congratulated the establishment of the partnership, saying:
“We are living in the age of highly advanced science and technology that requires us to have a new economic development paradigm for sustainable growth. Through convergence research based on the application of ICT and technology innovation, we will have new opportunities for development. I hope KAIST and the Imperial College London will be at the forefront of such endeavors in coming years.”With its history spanning over 100 years, the Imperial College London is a public research university located in London, UK, specializing in science, engineering, medicine, and business. The university is regarded as being one of the most prestigious universities in the world, having eminent alumni such as Thomas Henry Huxley (biologist), H.G. Wells (author), and Sir Alexander Fleming (pharmacologist).
From left to right: Provost James Stirling, Minister Moon-Gi Choi, and President Steve Kang
2013.11.12 View 8488 -
KAIST student wins Aerospace Student Papers Grand Prize
Dong-Il Yoo, a doctoral candidate under Professor Hyun-Chul Shim, at the Department of Aerospace Engineering, KAIST, has been awarded the Second Prize Award at the 11th Korea Aerospace Industries (KAI) Paper Contest. The award ceremony was held on October 30th at the media conference room at the KINTEX ADEX 2013 Exhibition in Seoul.
Yoo"s paper, titled "A Study on Virtual Pursuit Point-based Autonomous Air Combat Guidance Law for UCAV," is highly regarded for originality and creativity. The Field Robotics Center at the KAIST Institute, where Yoo conducted his research, also received the first prize at the 7th KAI Paper Contest.
The KAI Paper Contest was first organized in 2003 to promote academic interest and advance research and development in aerospace engineering among university students.
The KAI Paper Contest is one of the most prestigious contests in Korea. It is sponsored by the Ministry of Trade, Industry and Energy, the Ministry of Land, Infrastructure and Transport, the Korean Society for Aeronautical and Space Sciences, the Korea Aerospace Industries Association, and the Korea Civil Aviation Development Association.
Dong-Il Yoo (left) and Professor Hyun-Chul Shim (right)
2013.11.11 View 11089 -
The World Economic Forum Invites KAIST to 2014 Davos Forum
President Steve Kang and Distinguished Professor Sang Yup Lee have been invited by the World Economic Forum (WEF) to attend its annual meeting slated for January 22-25, 2014 in Davos-Klosters, Switzerland.
The president will also join the Global University Leaders Forum (GULF) to be held during the annual meeting. The GULF consists of leading research universities throughout the world, at which President Kang will address agenda related to higher education and research.
From September 11th to 13th, KAIST was invited to the WEF’s 2013 Summer Davos Forum held in Dalian, China. The Summer Davos Forum is recognized as a barometer of the world economy, and KAIST hosted three sessions there.
In a session titled “Smart Regulations,” Professor Sang Yup Lee hosted presentations and discussions under the topic of “How regulation models can strengthen technical innovation and expansion.” President Steve Kang, Peter Sands, CEO of Standard Chartered Bank Group, Mark Weinberger, CEO of Ernest & Young, and Peter Terium, CEO of RWE, participated in the discussions.
The KAIST delegates also presented and participated in a session titled “From Trade Center to Innovative Hub” to discuss how to lead innovations in Asia, as well as “Marine Resources: Finding New Frontier” to address issues of how to develop and manage oceanic resources for potential growth.
President Kang said, “The World Economic Forum allows us to introduce the results of our innovative and creative research to global leaders and to demonstrate that our global position continues to grow.”
The WEF has been hosting Summer Davos Forum in China since 2007. About 1,500 participants from over 90 countries joined in this year’s summer forum under the theme of “Innovation: Inevitable Mainstream.” New strategies for innovations and solutions for global threats were suggested through presentations and discussions in 125 sessions.
The World Economic Forum (WEF) is an independent, international, and non-profit organization based in Geneva, Switzerland. It is committed to improving the state of the world by engaging business, political, academic, and government leaders to shape global, regional and industry agenda.
Among the meetings and forums organized by the WEF, its annual meeting held each January in Davos, a.k.a. the Davos Forum, has been the best known gathering. The Davos Forum brings together some 2,500 top business leaders, international political leaders, selected intellectuals and journalists to discuss the most pressing issues facing the world including health and environment.
2013.11.07 View 10214 -
Professor Jae-Hyung Lee appointed as AIChE fellow
Professor Jae-Hyung Lee from the Department of Chemical and Bimolecular Engineering at KAIST was appointed as a fellow in the American Institute of Chemical Engineers (AIChE).
Established in 1908, AIChE is the largest association of chemical engineers worldwide, which now boasts more than 40,000 members from 90 countries.
Following Distinguished Professor Sang Yup Lee from the same department at KAIST, Professor Jae-Hyung Lee is the second Korean appointed as a fellow by the organization.
He has been acknowledged for his innovative research on the improvement of model predictive control of industrial processes.
Professor Lee is the director of the Saudi Armaco-KAIST CO2 Management Center at KAIST, a fellow of the Institute of Electrical and Electronics Engineers (IEEE) and the International Federation of Automatic Control (IFAC), and a member of the Korean Academy of Science and Technology.
He received the Young Investigator Award from the National Science Foundation (NSF) in 1994 and the Computing in Chemical Engineering Award from AIChE in 2013.
2013.11.05 View 8851 -
KAIST announced a novel technology to produce gasoline by a metabolically engineered microorganism
A major scientific breakthrough in the development of renewable energy sources and other important chemicals; The research team succeeded in producing 580 mg of gasoline per liter of cultured broth by converting in vivo generated fatty acids
For many decades, we have been relying on fossil resources to produce liquid fuels such as gasoline, diesel, and many industrial and consumer chemicals for daily use. However, increasing strains on natural resources as well as environmental issues including global warming have triggered a strong interest in developing sustainable ways to obtain fuels and chemicals.
Gasoline, the petroleum-derived product that is most widely used as a fuel for transportation, is a mixture of hydrocarbons, additives, and blending agents. The hydrocarbons, called alkanes, consist only of carbon and hydrogen atoms. Gasoline has a combination of straight-chain and branched-chain alkanes (hydrocarbons) consisted of 4-12 carbon atoms linked by direct carbon-carbon bonds.
Previously, through metabolic engineering of Escherichia coli (E. coli), there have been a few research results on the production of long-chain alkanes, which consist of 13-17 carbon atoms, suitable for replacing diesel. However, there has been no report on the microbial production of short-chain alkanes, a possible substitute for gasoline.
In the paper (entitled "Microbial Production of Short-chain Alkanes") published online in Nature on September 29, a Korean research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST) reported, for the first time, the development of a novel strategy for microbial gasoline production through metabolic engineering of E. coli.
The research team engineered the fatty acid metabolism to provide the fatty acid derivatives that are shorter than normal intracellular fatty acid metabolites, and introduced a novel synthetic pathway for the biosynthesis of short-chain alkanes. This allowed the development of platform E. coli strain capable of producing gasoline for the first time. Furthermore, this platform strain, if desired, can be modified to produce other products such as short-chain fatty esters and short-chain fatty alcohols.
In this paper, the Korean researchers described detailed strategies for 1) screening of enzymes associated with the production of fatty acids, 2) engineering of enzymes and fatty acid biosynthetic pathways to concentrate carbon flux towards the short-chain fatty acid production, and 3) converting short-chain fatty acids to their corresponding alkanes (gasoline) by introducing a novel synthetic pathway and optimization of culture conditions. Furthermore, the research team showed the possibility of producing fatty esters and alcohols by introducing responsible enzymes into the same platform strain.
Professor Sang Yup Lee said, "It is only the beginning of the work towards sustainable production of gasoline. The titer is rather low due to the low metabolic flux towards the formation of short-chain fatty acids and their derivatives. We are currently working on increasing the titer, yield and productivity of bio-gasoline. Nonetheless, we are pleased to report, for the first time, the production of gasoline through the metabolic engineering of E. coli, which we hope will serve as a basis for the metabolic engineering of microorganisms to produce fuels and chemicals from renewable resources."
This research was supported by the Advanced Biomass Research and Development Center of Korea (ABC-2010-0029799) through the Global Frontier Research Program of the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF), Republic of Korea. Systems metabolic engineering work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012-C1AAA001-2012M1A2A2026556) by MSIP through NRF.
Short-Chain Alkanes Generated from Renewable Biomass
This diagram shows the metabolic engineering of Escherichia coli for the production of short-chain alkanes (gasoline) from renewable biomass.
Nature Cover Page (September 29th, 2013)
2013.11.04 View 10974 -
Collaboration with Korea Institute of Energy Research
KAIST and the Korea Institute of Energy Research (KIER) agreed on September 4th to further collaboration on energy research such as the development of nano-based hybrid solar cells, bio-fuels, artificial photosynthesis, and carbon dioxide reduction.
The two institutions will select 11 research projects to focus on their cooperation. President Steve Kang (in the right) stood with Jooho Whang, the president of KIER (in the left), holding the signed memorandum of understanding.
2013.11.04 View 7312 -
KAIST's classes now available to take from all around the world
Signed a partnership agreement with Coursera to provide millions of people with online courses in science and technology.
The Korea Advanced Institute of Science and Technology (KAIST), a world-leading research university focusing on science, engineering and technology, joined a new, online platform for open access that serves the needs of Korean and global learners.
KAIST and Coursera, the world"s largest provider of massive open online courses (MOOCs), agreed on October 14th, 2013 to partner for the provision of internet-based open learning, through which the university expects to reinforce its current education initiative, Education 3.0.Steve Kang, president of KAIST, was upbeat about the partnership."We know the benefits and importance of online education that will significantly impact the landscape of today"s higher education. Hopefully, our partnership with Coursera will expand our initiative to continuously provide quality education globally."
With its network of 107 prestigious partner universities and public institutions worldwide, Coursera offers 482 free online courses across a wide field of humanities, science, engineering, and business to 5 million students around the globe.
KAIST will be able to utilize top-notch online courses and lecture contents available on the company"s website. The university can also supply its online courses to the global community, allowing the faculty"s top quality lectures to reach hundreds and thousands of students and adult learners throughout the world.Incorporating advanced information and communications technology, KAIST has implemented a new, smart education program, Education 3.0, since 2012 to effectively meet the growing demands of creating a better and more interactive learning and teaching environment for students and faculty. Under Education 3.0, students study online and meet in groups with a professor for discussions and problem solving.
Tae-Eog Lee, Director of the Center for Excellence in Learning & Teaching at KAIST, said:"We received a phenomenal response from students and professors to the courses made available under Education 3.0. For this year alone, we are offering 60 courses, such classes as calculus, general biology, basic programming, design and communication, bioengineering fundamentals, and logic and artificial intelligence."
Professor Lee added:"It has turned out that our education initiative is not only useful to our students but also quite popular among learners outside the university and Korea. It"s a great thing that KAIST can contribute to the world"s concerted efforts to provide equal opportunities for learning. At the same time, we look forward to seeing the benefits of MOOC-based content being used in our classrooms."
Founded in 2012 by two eminent Stanford University professors, Coursera has held a strong lead in MOOCs. Unlike the traditional online education model, open courseware (OCW), designed for simply sharing lecture materials including videos, slides, and data through the internet, MOOCs develop and evaluate courses, lecture contents, and delivery quality to meet high academic standards—In order to earn credits, subscribers (universities and students) are required to submit course registration, specification, and description; student attendance roster; homework and assignments; and assessment.
Daphne Koller, co-founder of Coursera, commented on the partnership agreement with KAIST:"We are honored to have so many brilliant minds working together to expand educational opportunities globally. To be able to offer courses from professors at the forefront of their fields to millions of people is truly remarkable, and our students remind us daily of the value of spreading this knowledge globally."
Among the partner universities and institutions are Stanford University, California Institute of Technology, Columbia University, École Polytechnique Fédérale de Lausanne, Technion-Israel Institute of Technology, the National University of Singapore, the University of Tokyo, the World Bank, and Shanghai Jiao Tong University.
President Steve Kang (in the left) singed a partnership agreement with Dr. Daphne Koller (in the right), president and CEO of Coursera.
2013.11.04 View 9253 -
KAIST Hosted the 6th International Presidential Forum on Global Research Universities
More than 120 global leaders from higher education, private and public sectors, to discuss the promotion of economic growth through knowledge creation and entrepreneurship
The Korea Advanced Institute of Science and Technology (KAIST) held the 6th International Presidential Forum on Global Research Universities (IPFGRU) on October 15th at the Westin Chosun Hotel in Seoul, Republic of Korea.
About 64 presidents and vice presidents from 57 research universities in 28 nations attended for a presentation and panel discussion on the topic of “The Role and Responsibility of Research Universities: Knowledge Creation, Technology Transfer, and Entrepreneurship.”Annually held, the forum is organized to promote excellence and innovation in higher education and provide a place for discussion among prominent research university leaders and key policy-makers in the private and public sectors from across the world.Among the notable universities attending the 2013 forum were the University of California, Irvine, the École Polytechnique Fédérale de Lausanne, Technische Universität Berlin, Technion-Israel Institute of Technology, Tokyo Institute of Technology, Rice University, the University of Waterloo, and Massachusetts Institute of Technology (MIT). Government officials as well as representatives from business and industry such as Samsung Electronics, Korea Telecom, and Elsevier also joined the event.
The forum was proceeded with three separate sessions: Enabling Knowledge Creation, Entrepreneurship & University-Based Technology Transfer, and Higher Education & Strategic Knowledge Creation: Specialization & Performance, through which speakers and panelists examined how universities have played a role in knowledge creation and technology transfer, and ultimately how they have contributed to the development of national economies.
Keynote speakers were Michael Drake, chancellor of UC Irvine, and Jörg Steinbach, president of Technische Universität Berlin. Forum participants shared their experiences and insights in starting up knowledge- and technolgy-based new businesses.
Steve Kang, president of KAIST, talked about the purpose of the 2013 IPFGRU:
“In the face of an ever-changing economic climate driven by shifts in technological advancement, demographic trends, and global integration, the role of research universities is becoming ever more significant in achieving sustainable economic growth. This forum will help participants from around the world to define the choices ahead as universities seek the most productive and beneficial models for cooperation with industry, venture startups, and government.”For the 2013 IPFGRU, Ministry of Science, ICT, and Future Planning, ROK, Saudi Aramco, Samsung Heavy Industries, S-Oil, Elsevier, Thomson Reuters, and the Korea Economic Daily were forum sponsors.
2013.11.04 View 9527 -
A powerful strategy for developing microbial cell factories by employing synthetic small RNAs
The current systems for the production of chemicals, fuels and materials heavily rely on the use of fossil resources. Due to the increasing concerns on climate change and other environmental problems, however, there has been much interest in developing biorefineries for the production of such chemicals, fuels and materials from renewable resources. For the biorefineries to be competitive with the traditional fossil resource-based refineries, development of high performance microorganisms is the most important as it will affect the overall economics of the process most significantly. Metabolic engineering, which can be defined as purposeful modification of cellular metabolic and regulatory networks with an aim to improve the production of a desired product, has been successfully employed to improve the performance of the cell. However, it is not trivial to engineer the cellular metabolism and regulatory circuits in the cell due to their high complexity.
In metabolic engineering, it is important to find the genes that need to be amplified and attenuated in order to increase the product formation rate while minimizing the production of undesirable byproducts. Gene knock-out experiments are often performed to delete those metabolic fluxes that will consequently result in the increase of the desired product formation. However, gene knock-out experiments require much effort and time to perform, and are difficult to do for a large number of genes. Furthermore, the gene knock-out experiments performed in one strain cannot be transferred to another organism and thus the whole experimental process has to be repeated. This is a big problem in developing a high performance microbial cell factory because it is required to find the best platform strain among many different strains. Therefore, researchers have been eager to develop a strategy that allows rapid identification of multiple genes to be attenuated in multiple strains at the same time.
A Korean research team led by Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering from the Korea Advanced Institute of Science and Technology (KAIST) reported the development of a strategy for efficiently developing microbial cell factories by employing synthetic small RNAs (sRNAs). They first reported the development of such system in Nature Biotechnology last February. This strategy of employing synthetic sRNAs in metabolic engineering has been receiving great interest worldwide as it allows easy, rapid, high-throughput, tunable, and un-doable knock-down of multiple genes in multiple strains at the same time. The research team published a paper online on August 8 as a cover page (September issue) in Nature Protocols, describing the detailed strategy and protocol to employ synthetic sRNAs for metabolic engineering.
In this paper, researchers described the detailed step-by-step protocol for synthetic sRNA-based gene expression control, including the sRNA design principles. Tailor-made synthetic sRNAs can be easily manipulated by using conventional gene cloning method. The use of synthetic sRNAs for gene expression regulation provides several advantages such as portability, conditionality, and tunability in high-throughput experiments. Plasmid-based synthetic sRNA expression system does not leave any scar on the chromosome, and can be easily transferred to many other host strains to be examined. Thus, the construction of libraries and examination of different host strains are much easier than the conventional hard-coded gene manipulation systems. Also, the expression of genes can be conditionally repressed by controlling the production of synthetic sRNAs. Synthetic sRNAs possessing different repression efficiencies make it possible to finely tune the gene expression levels as well. Furthermore, synthetic sRNAs allow knock-down of the expression of essential genes, which was not possible by conventional gene knock-out experiments.
Synthetic sRNAs can be utilized for diverse experiments where gene expression regulation is needed. One of promising applications is high-throughput screening of the target genes to be manipulated and multiple strains simultaneously to enhance the production of chemicals and materials of interest. Such simultaneous optimization of gene targets and strains has been one of the big challenges in metabolic engineering. Another application is to fine tune the expression of the screened genes for flux optimization, which would enhance chemical production further by balancing the flux between biomass formation and target chemical production. Synthetic sRNAs can also be applied to finely regulating genetic interactions in a circuit or network, which is essential in synthetic biology. Once a sRNA scaffold-harboring plasmid is constructed, tailor-made, synthetic sRNAs can be made within 3-4 days, followed by the desired application experiments.
Dr. Eytan Zlotorynski, an editor at Nature Protocols, said "This paper describes the detailed protocol for the design and applications of synthetic sRNA. The method, which has many advantages, is likely to become common practice, and prove useful for metabolic engineering and synthetic biology studies."
This paper published in Nature Protocols will be useful for all researchers in academia and industry who are interested in the use of synthetic sRNAs for fundamental and applied biological and biotechnological studies.
This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012-C1AAA001-2012M1A2A2026556) and the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) of the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea.
2013.10.31 View 8847 -
First Prize in the 2013 International Military Science and Technology Contest
Professor James R. Morrison and his students of the Industrial and Systems Engineering Department at KAIST were awarded the first prize in the 2013 International Military Science and Technology Contest organized by the Defense Acquisition Program Administration held in COEX from July 11 to 14.
The research group, Byungduk Song (Ph.D candidate), Jonghoe Kim (Ph.D candidate), Hyolin Park (MS candidate) and Professor James R. Morrison, received the first prize with their paper entitled “Automated and persistent UAV system for a complementary method for border patrol and target tracking.”
The Defense Acquisition Program Administration is the host of the annual contest which aims to contribute to the future of the defense industry and to expand technology exchange between private institutes and the military through the coordination of defense technology and advanced technology from industrial and educational cooperation.Professor Morrison’s team received the honor of the first-place prize out of 56 competitors from within Korea and 7 from overseas in the field of Synthetic New Technology/Academic Thesis.
2013.10.31 View 8193 -
Core Technology for Lithium Air Secondary Battery Developed
KAIST-Kyonggi University joint research team developed composite catalyst out of nano fiber and graphene
Five times improvement in capacity compared to lithium-ion secondary battery, driving 800 km at maximum
The core technology for lithium air secondary battery, the next generation high capacity battery, has been developed.
A research team formed by KAIST Department of Materials Science’s Professors Il-Doo Kim and Seokwoo Jeon, and Kyonggi University Department of Materials Science’s Professor Yong-Joon Park has created a lithium air secondary battery, with five times greater storage than the lithium-ion secondary battery, by developing a nano fiber-graphene composite catalyst. The research results are published in the August 8th online edition of Nano Letters.
A cathode of a lithium-ion battery consists of graphite and an anode of the battery consists of a lithium transition metal oxide. Lithium-ion batteries are widely used in mobile phones and laptops. However, lithium-ion batteries cannot support electric vehicles, providing energy for only 160 kilometers on one full charge. The lithium air secondary battery just developed by the research team uses lithium on the cathode and oxygen on the anode. It is earning a popular acknowledgement among the next generation secondary battery research community for having lightweight mass and high energy density.
However, lithium-ion batteries remain difficult to commercialize because of their short lifespan. Lithium and oxygen meet up to form lithium oxide (Li2O2) at discharge, and decompose again at charge. In a traditional lithium air battery, this cycle does not occur smoothly and results in high resistance, thereby reducing the lifespan of the battery. It is thus essential to develop high efficiency catalyst that facilitates the formation and decomposition of lithium oxides.
The research team used electric radiation to develop a nano composite catalyst by mixing cobalt oxide nano fiber and graphene. The performance of the battery has been maximized by settling nonoxidative graphene, which has high specific surface area and electrical conductivity, on catalyst active cobalt oxide nano fiber. Applying the nano composite catalyst on both poles of the lithium air battery resulted in an improved lifespan of over 80 recharge cycles with capacity greater than 100mAh/g, five times greater than a lithium ion battery. The newly discovered charge-discharge property is the highest among the reported performances of the lithium air battery so far.
The lithium air battery is cheap to make, as the main materials are metal oxide and graphene. “There are yet more issues to resolve such as stability, but we will collaborate with other organizations to open up the era of electronic vehicles,” said Professor Il-Doo Kim. “We hope to contribute to vitalizing the fields of next generation lithium air battery by leading nanocatalyst synthesis technology, one of the core materials in the fields of secondary battery,” Professor Kim spoke of his aspiration.
The graduate students participated in the research are Won-Hee Ryu, a postdoctorate at KAIST Department of Materials Science, Sungho Song, a PhD candidate at KAIST Department of Materials Science, and Taek-Han Yoon, a graduate student at Kyonggi University.
Picture I: Schematic Diagram of Lithium Air Battery Made of Nano Composite Catalysts
Picture II: Images of Cobalt Oxide Nano Fibers and Graphene Nano Composite Catalysts
Picture III: Images of Manufacturing Process of Cobalt Oxide Nano Fibers and Graphene Nano Composite Catalysts for Lithium Air Battery
2013.10.18 View 11050 -
Therapy developed to induce Angiogenesis of Retina
- Junyeop Lee, Graduate School of Medical Sciences and Engineering
- Research results expected to be applied for treatment of diabetic retinopathy
A major clue to treatment of retinovascular disease, which causes blindness, has been found. The key to protection of the retinal nerve is the angiogenic protein that promotes healthy retinal vessel growth around the retina, which usually does not receive blood supply readily. This research offers a beginning to the possible improvement of therapy for diabetic retinopathy1 and retinopathy of prematurity2. Also important to the research is the fact that the ophthalmology specialist researcher, currently undergoing professional training, provided the results.
KAIST Graduate School of Medical Sciences and Engineering’s Junyeop Lee is the opthalmology specialist, who carried out the research under supervision by academic advisers Gyuyeong Go and Wookjun Yoo. The Ministry of Science, ICT and Future Planning as well as the National Research Foundation of Korea have funded his research. The research results have been published as a cover paper on ‘Science Translational Medicine’ on 18th August. This journal is a sister publication of Science, which is prestigious in the field of translational medicine that ties the basic science with clinical medicine. (Thesis title: Angiopoietin-1 Guides Directional Angiogenesis Through Integrin αvβ5 Signaling for Recovery of Ischemic Retinopathy)
The traditional treatment of diabetic retinopathy includes laser photocoagulation to destroy the retinal tissues or antibody therapeutics, which prevents vessel proliferation and blood leaking. The advantage of antibody therapeutics3 is that it retains the retinal nerves, however, it is not the fundamental solution but merely a temporary one, which requires repeated treatments.
The research team identified that Angiopoietin-14 protein, known as essential for growth and stabilization of vessels, also plays an important role in retinal vessel growth. The protein protects the retinal nerves, as well as provides improvement for retinal ischemia5 that is the root cause of vision loss due to retinal hemorrhages. It is expected to become a key to finding fundamental treatment method – by providing sufficient blood supply to the retina, thereby preserving the retinal nerve functions.
The results show that administration of Angiopoietin-1 to retinopathy mouse model promotes growth of healthy vessel growth, further preventing abnormal vessel growth, retinal hemorrhage and vision loss due to retinal ischemia.
Junyeop Lee said, “This research has identified that Angiopoietin-1 is an important factor in retinal vessel generation and stabilization. The paradigm will shift from traditional treatment method, which prevents vessel growth, to a new method that generates healthy vessels and strengthens vessel functions.”
1 Diabetic retinopathy: This retinovascular disease is a diabetic complication caused by insufficient blood supply. It is the major causes of blindness in adults.
2 Retinopathy of prematurity: The retinal vascular disease that occurs in premature infants with incomplete retinal vascular development. It is also the most common cause of blindness in children.
3 Antibody Therapeutics: Antibody developed to selectively inhibit abnormal blood vessel growth and leakage. Typical antibody therapeutics is Avastin and Lucentis, which hinder vascular endothelial growth factor (VEGF).
4 Angiopoietin-1: A critical growth factor that induces the production of healthy blood vessels and maintains the stability of the created vessel.
5 Retinal ischemia: State of ailment where retinal tissue blood supply is not sufficient.
Figure 1. Retinopathy mouse models show that, in comparison to the control group, the VEGF-Trap treatment and Angiopoietin-1 (Ang1) treatment groups significantly suppresses the pathological vascular proliferation. In addition, the Ang 1 group show vessel growth toward the central avascular area (region of retinal ischemia), which is not observed in VEGF-Trap treatment.
Figure 2. Reduced retinal ischemia, retinal bleeding and blood vessel normalization by Angiopoietin-1. Retinal ischemic region (arrow) and retinal bleeding significantly reduced in the Angiopoietin-1 (Ang1) treatment model in comparison to control group (left). The newly generated vessels in Ang 1 model are structurally supported by perivascular cells as normal retinal vessels do (right).
2013.10.12 View 10514