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A Comprehensive Metabolic Map for Bio-Based Chemicals Production
A KAIST research team completed a metabolic map that charts all available strategies and pathways of chemical reactions that lead to the production of various industrial bio-based chemicals.
The team was led by Distinguished Professor Sang Yup Lee, who has produced high-quality metabolic engineering and systems engineering research for decades, and made the hallmark chemicals map after seven years of studies.
The team presented a very detailed analysis on metabolic engineering for the production of a wide range of industrial chemicals, fuels, and materials. Surveying the current trends in the bio-based production of chemicals in industrial biotechnology, the team thoroughly examined the current status of industrial chemicals produced using biological and/or chemical reactions.
This comprehensive map is expected to serve as a blueprint for the visual and intuitive inspection of biological and/or chemical reactions for the production of interest from renewable resources. The team also compiled an accompanying poster to visually present the synthetic pathways of chemicals in the context of their microbial metabolism.
As metabolic engineering has become increasing powerful in addressing limited fossil resources, climate change, and other environmental issues, the number of microbially produced chemicals using biomass as a carbon source has increased substantially. The sustainable production of industrial chemicals and materials has been explored with micro-organisms as cell factories and renewable nonfood biomass as raw materials for alternative petroleum. The engineering of these micro-organism has increasingly become more efficient and effective with the help of metabolic engineering – a practice of engineering using the metabolism of living organisms to produce a desired metabolite.
With the establishment of systems metabolic engineering – the integration of metabolic engineering with tools and strategies from systems biology, synthetic biology and evolutionary engineering – the speed at which micro-organisms are being engineered has reached an unparalleled pace.
In order to evaluate the current state at which metabolically engineered micro-organisms can produce a large portfolio of industrial chemicals, the team conducted an extensive review of the literature and mapped them out on a poster. This resulting poster, termed the bio-based chemicals map, presents synthetic pathways for industrial chemicals, which consist of biological and/or chemical reactions.
Industrial chemicals and their production routes are presented in the context of central carbon metabolic pathways as these key metabolites serve as precursors for the chemicals to be produced. The resulting biochemical map allows the detection and analysis of optimal synthetic pathways for a given industrial chemical. In addition to the poster, the authors have compiled a list of chemicals that have successfully been produced using micro-organisms and a list of the corresponding companies producing them commercially. This thorough review of the literature and the accompanying analytical summary will be an important resource for researchers interested in the production of chemicals from renewable biomass sources.
Metabolically engineered micro-organisms have already made a huge contribution toward the sustainable production of chemicals using renewable resources. Professor Lee said he wanted a detailed survey of the current state and capacity of bio-based chemicals production.
“We are so excited that this review and poster will expand further discussion on the production of important chemicals through engineered micro-organisms and also combined biological and chemical means in a more sustainable manner,” he explained.
This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biofineries from the Ministry of Science and ICT through the National Research Foundation of Korea.
For further information, Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST ( leesy@kaist.ac.kr , Tel: +82-42-350-3930)
Figure: Bio-based chemicals production through biological and chemical routes. This metabolic map describes representative chemicals that can be produced either by biological and/or chemical means. Red arrows represent chemical routes and blue arrows represent biological routes. Intermediate metabolites in the metabolism of a living organism can serve as a platform toward the production of industrially relevant chemicals. A more comprehensive map presented by the team can be found as a poster in the review.
2019.01.15 View 7365 -
Distinguished Alumni Awardees 2018
The KAIST Alumni Association (KAA) announced four recipients of the Distinguished Alumni Awards 2018. The Distinguished Alumni Awards recognize graduates who have achieved outstanding accomplishments in their professional and personal lives, and who have been an inspiration to fellow alumni and students in Korea and around the globe. Since the establishment of the award in 1992, a total of 99 alumni at home and abroad have been honored as recipients. The awards ceremony will take place during the New Year Alumni Reception on January 19 in Seoul.
Yeungnam University President Gil-Soo Sur (’75 MS, ’78 PhD in Chemistry) has demonstrated leadership in higher education and gained trust in academia for playing a leading role in educational innovation as well as serving as an educator who has fostered outstanding research talents for decades.
Professor Kwang-Soo Kim (’77 MS, ’79 PhD in Life Science) is the director of the Molecular Neurobiology Laboratory at McLean Hospital at Harvard Medical School. He has more than 20 years of experience investigating molecular and developmental neurobiology of the midbrain dopamine neuronal system. He has contributed to developing cell replacement therapy for Parkinson’s disease and has pioneered a generation of safe human-induced pluripotent stem cells through the direct delivery of reprogrammed proteins.
Young-Hwan Moon (’82 MS, ’87 PhD in Chemistry and Biomolecular Engineering) is the CEO of Coretech, which specializes in producing specialty gases and environmental catalysts required for chemical processes. He was recognized for enhancing national competence by securing competitive technology for manufacturing products.
Young-Hyun Jun (’84 MS, ’86 PhD in Electrical Engineering), the CEO of Samsung SDI, is a globally renowned expert in memory semiconductors. By bringing about innovative technology to enhance productivity and processes, he led Samsung Electronics to become the number one company at the global level in the field of semiconductors.
2019.01.14 View 4433 -
KAIST Presents Innovations at CES 2019
Ten of the most innovative technologies spun off from KAIST made a debut at the Consumer Electronics Show (CES) 2019, the world’s largest consumer electronics and IT exhibition being held in Las Vegas from January 8 to 11. The KAIST booth at the CES featured technologies made by KAIST research teams and five startup companies including LiBEST, Memslux, and Green Power. In particular, the KAIST Alumni Association invited 33 aspiring alumni entrepreneurs selected from the KAIST Startup Competition to the show.
At the exhibition, KAIST is presenting innovations in the fields of AI and Bio-IT convergence for the Fourth Industrial Revolution. These include real-time upscaling from Full HD to 4K UHD using AI deep learning-based convolutional neural networks (Professor Munchurl Kim, School of Electrical Engineering) and an AI conversation agent that responds to user’s emotions (Professor Soo-Young Lee, School of Electrical Engineering).
Other technologies include optimal drug target identification by cancer cell type through drug response prediction to be used in personalized cancer treatments (Professor Kwang-Hyun Cho, Department of Bio and Brain Engineering), a nanofiber-based color changing gas sensor with greater sensitivity than conventional paper-based color changing sensors (Professor Il-Doo Kim, Department of Materials Science and Engineering), and functional near-infrared spectroscopy (fNIRS) for brain imaging and muscle fatigue measurement (Professor Hyeonmin Bae, School of Electrical Engineering).
The KAIST booth also features startups founded by KAIST alumni including LiBEST with a flexible lithium polymer secondary cell optimized for smart wearable devices and Rempus with a high-performance lithium ion cell packaging technology for outstanding safety, high capacity, long life, and fast charging.
Green Power and Smart Radar Systems are also joining the booth with a highly efficient and eco-friendly wireless charging system for electrical cars, and a 4D image radar sensor that detects 3D images and speed in real time for applications in self-driving cars, drones, and security systems respectively.
Faculty-founded startup Memslux (CEO Jun-Bo Yoon, School of Electrical Engineering) is presenting a transparent surface light source solution for next-generation display devices.
Associate Vice President of Office of University-Industry Cooperation Kyung Cheol Choi said, “I believe that universities should play a role in connecting technological innovations to business startups for creating value at a global level. In that sense, it is a great opportunity to present innovative technologies from KAIST and promote outstanding KAIST startups at CES 2019. Hopefully, this experience will lead to joint R&D, investment, cooperation, and international technology transfer contracts with leading companies from around the world.”
Here are the five key technologies presented by KAIST at CES 2019.
2019.01.10 View 8347 -
Technology to Control Near-Field Thermal Radiation
(from left clockwise: Professor Seung Seob Lee, Professor Bong Jae Lee, PhD Mikyung Lim and PhD candidate Jaeman Song)
A KAIST research team succeeded in measuring and controlling the near-field thermal radiation between metallo-dielectric (MD) multilayer structures.
Their thermal radiation control technology can be applied to next-generation semiconductor packaging, thermophotovoltaic cells and thermal management systems. It also has the potential to be applied to a sustainable energy source for IoT sensors.
In the nanoscale gaps, thermal radiation between objects increases greatly with closer distances. The amount of heat transfer in this scale was found to be from 1,000 to 10,000 times greater than the blackbody radiation heat transfer, which was once considered the theoretical maximum for the rate of thermal radiation. This phenomenon is called near-field thermal radiation. With recent developments in nanotechnology, research into near-field thermal radiation between various materials has been actively carried out.
Surface polariton coupling generated from nanostructures has been of particular interest because it enhances the amount of near-field thermal radiation between two objects, and allows the spectral control of near-field thermal radiation. This advantage has motivated much of the recent theoretical research on the application of near-field thermal radiation using nanostructures, such as thin films, multilayer nanostructures, and nanowires. Nevertheless, thus far, most of the studies have focused on measuring near-field thermal radiation between isotropic materials.
A joint team led by Professor Bong Jae Lee and Professor Seung Seob Lee from the Department of Mechanical Engineering succeeded in measuring near-field thermal radiation according to the vacuum distance between MD multilayer nanostructures by using a custom MEMS (Micro-Electro-Mechanical Systems)-device-integrated platform with three-axis nanopositioner.
MD multilayer nanostructures refer to structures in which metal and dielectric layers with regular thickness alternate. The MD single-layer pair is referred to as a unit cell, and the ratio of the thickness occupied by the metal layer in the unit cell is called the fill factor.
By measuring the near-field thermal radiation with a varying number of unit cells and the fill factor of the multilayer nanostructures, the team demonstrated that the surface plasmon polariton coupling enhances near-field thermal radiation greatly, and allows spectral control over the heat transfer.
Professor B. J. Lee said, “The isotropic materials that have so far been studied experimentally had limited spectral control over the near-field thermal radiation. Our near-field thermal radiation control technology using multilayer nanostructures is expected to become the first step toward developing various near-field thermal radiation applications.”
This research, led by PhD Mikyung Lim and PhD candidate Jaeman Song, was published in Nature Communications on October 16.
Figure 1. Experimental setup for measuring near-field thermal radiation between MD multilayers
Figure 2. Investigation of manipulated near-field heat flux by modifying the surface conditions with MD multilayers
2019.01.04 View 6354 -
Professor Jeong-Ho Lee Named the KAISTian of 2018
(Professor Jeong-Ho Lee (right) poses with President Sung-Chul Shin)
Professor Jeong-Ho Lee from the Graduate School of Medical Science and Engineering was selected as the KAISTian of the Year of 2018. The award was established in 2001 and recognizes the most outstanding scholars who have made significant research and scholastic achievements during the year. Professor Lee was awarded during the New Year ceremony held in the auditorium on January 2.
Professor Lee has investigated mutations arising in the brain for decades and has published in renowned journals such as Nature, Nature Medicine, and Cell. Last August, Professor Lee reported breakthrough research on glioblastoma in Nature, giving insight into understanding how the mutation causing glioblastoma starts and suggested novel ways to treat glioblastoma, which was thought to be incurable. (Click for more)
Professor Lee’s Translational Neurogenetics Laboratory lab is investigating innovative diagnostics and therapeutics for untreatable brain disorders including intractable epilepsy and glioblastoma. To commercialize his technology, he established the tech-startup SoVarGen and now works as its CTO.
Professor Lee credited all his lab colleagues and staff. “I know all of this research would not have possible without their sweat and effort. I am happy to receive this honorable award on behalf of them.”
Remembering the beginning of his career at KAIST in 2012, Professor Lee said “KAIST seemed to be a very high and formidable barrier for me, after completing my medical education in Korea. I thank my department professors and colleagues who led me to focus on the research path that I really wanted. They provided everything for my research environment to help make good results.”
“I will continue to strive for promoting the well-being of humanity by addressing various incurable diseases as well as developing novel therapeutics. That will be the way to promote the stature of KAIST at home and abroad,” he added.
2019.01.02 View 5978 -
Ultrathin Digital Camera Inspired by Xenos Peckii Eyes
(Professor Ki-Hun Jeong from the Department of Bio and Brain Engineering)
The visual system of Xenos peckii, an endoparasite of paper wasps, demonstrates distinct benefits for high sensitivity and high resolution, differing from the compound eyes of most insects. Taking their unique features, a KAIST team developed an ultrathin digital camera that emulates the unique eyes of Xenos peckii.
The ultrathin digital camera offers a wide field of view and high resolution in a slimmer body compared to existing imaging systems. It is expected to support various applications, such as monitoring equipment, medical imaging devices, and mobile imaging systems.
Professor Ki-Hun Jeong from the Department of Bio and Brain Engineering and his team are known for mimicking biological visual organs. The team’s past research includes an LED lens based on the abdominal segments of fireflies and biologically inspired anti-reflective structures.
Recently, the demand for ultrathin digital cameras has increased, due to the miniaturization of electronic and optical devices. However, most camera modules use multiple lenses along the optical axis to compensate for optical aberrations, resulting in a larger volume as well as a thicker total track length of digital cameras. Resolution and sensitivity would be compromised if these modules were to be simply reduced in size and thickness.
To address this issue, the team have developed micro-optical components, inspired from the visual system of Xenos peckii, and combined them with a CMOS (complementary metal oxide semiconductor) image sensor to achieve an ultrathin digital camera.
This new camera, measuring less than 2mm in thickness, emulates the eyes of Xenos peckii by using dozens of microprism arrays and microlens arrays. A microprism and microlens pair form a channel and the light-absorbing medium between the channels reduces optical crosstalk. Each channel captures the partial image at slightly different orientation, and the retrieved partial images are combined into a single image, thereby ensuring a wide field of view and high resolution.
Professor Jeong said, “We have proposed a novel method of fabricating an ultrathin camera. As the first insect-inspired, ultrathin camera that integrates a microcamera on a conventional CMOS image sensor array, our study will have a significant impact in optics and related fields.”
This research, led by PhD candidates Dongmin Keum and Kyung-Won Jang, was published in Light: Science & Applications on October 24, 2018.
Figure 1. Natural Xenos peckii eye and the biological inspiration for the ultrathin digital camera (Light: Science & Applications 2018)
Figure 2. Optical images captured by the bioinspired ultrathin digital camera (Light: Science & Applications 2018)
2018.12.31 View 8700 -
Sound-based Touch Input Technology for Smart Tables and Mirrors
(from left: MS candidate Anish Byanjankar, Research Assistant Professor Hyosu Kim and Professor Insik Shin)
Time passes so quickly, especially in the morning. Your hands are so busy brushing your teeth and checking the weather on your smartphone. You might wish that your mirror could turn into a touch screen and free up your hands. That wish can be achieved very soon. A KAIST team has developed a smartphone-based touch sound localization technology to facilitate ubiquitous interactions, turning objects like furniture and mirrors into touch input tools.
This technology analyzes touch sounds generated from a user’s touch on a surface and identifies the location of the touch input. For instance, users can turn surrounding tables or walls into virtual keyboards and write lengthy e-mails much more conveniently by using only the built-in microphone on their smartphones or tablets. Moreover, family members can enjoy a virtual chessboard or enjoy board games on their dining tables.
Additionally, traditional smart devices such as smart TVs or mirrors, which only provide simple screen display functions, can play a smarter role by adding touch input function support (see the image below).
Figure 1.Examples of using touch input technology: By using only smartphone, you can use surrounding objects as a touch screen anytime and anywhere.
The most important aspect of enabling the sound-based touch input method is to identify the location of touch inputs in a precise manner (within about 1cm error). However, it is challenging to meet these requirements, mainly because this technology can be used in diverse and dynamically changing environments. Users may use objects like desks, walls, or mirrors as touch input tools and the surrounding environments (e.g. location of nearby objects or ambient noise level) can be varied. These environmental changes can affect the characteristics of touch sounds.
To address this challenge, Professor Insik Shin from the School of Computing and his team focused on analyzing the fundamental properties of touch sounds, especially how they are transmitted through solid surfaces.
On solid surfaces, sound experiences a dispersion phenomenon that makes different frequency components travel at different speeds. Based on this phenomenon, the team observed that the arrival time difference (TDoA) between frequency components increases in proportion to the sound transmission distance, and this linear relationship is not affected by the variations of surround environments.
Based on these observations, Research Assistant Professor Hyosu Kim proposed a novel sound-based touch input technology that records touch sounds transmitted through solid surfaces, then conducts a simple calibration process to identify the relationship between TDoA and the sound transmission distance, finally achieving accurate touch input localization.
The accuracy of the proposed system was then measured. The average localization error was lower than about 0.4 cm on a 17-inch touch screen. Particularly, it provided a measurement error of less than 1cm, even with a variety of objects such as wooden desks, glass mirrors, and acrylic boards and when the position of nearby objects and noise levels changed dynamically. Experiments with practical users have also shown positive responses to all measurement factors, including user experience and accuracy.
Professor Shin said, “This is novel touch interface technology that allows a touch input system just by installing three to four microphones, so it can easily turn nearby objects into touch screens.”
The proposed system was presented at ACM SenSys, a top-tier conference in the field of mobile computing and sensing, and was selected as a best paper runner-up in November 2018.
(The demonstration video of the sound-based touch input technology)
2018.12.26 View 8952 -
Fabrication of Shape-conformable Batteries with 3D-Printing
(from left: Dr. Bok Yeop Ahn, Dr. Chanhoon Kim, Professor Il-Doo Kim and Professor Jennifer A. Lewis)
Flexible, wireless electronic devices are rapidly emerging and have reached the level of commercialization; nevertheless, most of battery shapes are limited to either spherical and/or rectangular structures, which results in inefficient space use. Professor Il-Doo Kim’s team from the Department of Materials Science at KAIST has successfully developed technology to significantly enhance the variability of battery design through collaboration research with Professor Jennifer A. Lewis and her team from the School of Engineering and Applied Sciences at Harvard University.
Most of the battery shapes today are optimized for coin cell and/or pouch cells. Since the battery as an energy storage device occupies most of the space in microelectronic devices with different designs, new technology to freely change the shape of the battery is required.
The KAIST-Harvard research collaboration team has successfully manufactured various kinds of battery shapes, such as ring-type, H, and U shape, using 3D printing technology. And through the research collaboration with Dr. Youngmin Choi at the Korea Research Institute of Chemical Technology (KRICT), 3D-printed batteries were applied to small-scale wearable electronic devices (wearable light sensor rings).
The research group has adopted environmentally friendly aqueous Zn-ion batteries to make customized battery packs. This system, which uses Zn2+ instead of Li+ as charge carriers, is much safer compared with the conventional lithium rechargeable batteries that use highly inflammable organic electrolytes. Moreover, the processing conditions of lithium-ion batteries are very complicated because organic solvents can ignite upon exposure to moisture and oxygen.
As the aqueous Zn-ion batteries adopted by the research team are stable upon contact with atmospheric moisture and oxygen, they can be fabricated in the ambient air condition, and have advantages in packaging since packaged plastic does not dissolve in water even when plastic packaging is applied using a 3D printer.
To fabricate a stable cathode that can be modulated in various forms and allows high charge-discharge, the research team fabricated a carbon fiber current collector using electrospinning process and uniformly coated electrochemically active polyaniline conductive polymer on the surface of carbon fiber for a current collector-active layer integrated cathode. The cathode, based on conductive polyaniline consisting of a 3D structure, exhibits very fast charging speeds (50% of the charge in two minutes) and can be fabricated without the detachment of active cathode materials, so various battery forms with high mechanical stability can be manufactured.
Prof. Kim said, “Zn-ion batteries employing aqueous electrolytes have the advantage of fabrication under ambient conditions, so it is easy to fabricate the customized battery packs using 3D printing.”
“3D-printed batteries can be easily applied for niche applications such as wearable, personalized, miniaturized micro-robots, and implantable medical devices or microelectronic storage devices with unique designs,” added Professor Lewis.
With Dr. Chanhoon Kim in the Department of Materials Science and Engineering at KAIST and Dr. Bok Yeop Ahn School of Engineering and Applied Sciences at Harvard University participating as equally contributing first authors, this work was published in the December issue of ACS Nano.
This work was financially supported by the Global Research Laboratory (NRF-2015K1A1A2029679) and Wearable Platform Materials Technology Center (2016R1A5A1009926).
Figure 1.Fabrication of shape-conformable batteries based on 3D-printing technology and the application of polyaniline carbon nanofiber cathodes and wearable electronic devices
Figure 2.Fabricated shape-conformable batteries based on a 3D-printing method
Meanwhile, Professor Il-Doo Kim was recently appointed as an Associate Editor of ACS Nano, a highly renowned journal in the field of nanoscience.
Professor Kim said, “It is my great honor to be an Associate Editor of the highly renowned journal ACS Nano, which has an impact factor reaching 13.709 with 134,596 citations as of 2017. Through the editorial activities in the fields of energy, I will dedicate myself to improving the prominence of KAIST and expanding the scope of Korea’s science and technology. I will also contribute to carrying out more international collaborations with world-leading research groups.”
(Associate Editor of ACS Nano Professor Il-Doo Kim)
2018.12.20 View 10668 -
Optimal Immuno-Therapeutic Strategies for Liver Cancer
KAIST medical scientists have presented a heterogeneity of immune cell exhaustion in the cancer environment, providing evidence and rationale for designing optimal strategies for immune checkpoint inhibitors in liver cancer patients.
They succeeded in distinguishing the hepatocellular carcinoma group from the exhausted tumor infiltrating immune cell composition of liver cancer patients. The study, conducted in collaboration with Asan Medical Center, confirmed the applicability for liver cancer patients, providing a new path for personalized precision medicine as well as a new model for translational research.
Our immune system is able to destroy cancerous cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. One of the mechanisms that has evolved to prevent eradication by the immune system is to functionally silence effector T cells, termed T-cell exhaustion, that is mainly mediated by immune checkpoint molecules such as PD-1, TIM-3, and LAG-3.
Recent breakthroughs and encouraging clinical results with various immune checkpoint inhibitors (ICIs), such as anti-PD-1 monoclonal antibodies (mAbs) and anti-CTLA-4 mAbs, have demonstrated tremendous potential to cure cancers through the immune activation of exhausted T cells. Immune checkpoint inhibitors showed significant clinical benefits for several types of cancers, leading to their wide application in clinical practice.
Anti-PD1 blocking antibodies are one of the most representative agents in this class of drug. However, it has been challenging to precisely understand the biological and clinical significance of T-cell exhaustion in cancer. A KAIST research team led by Professor Su-Hyung Park reported the heterogeneity of T-cell exhaustion in hepatocellular carcinoma (HCC) and its potential clinical implications in Gastroenterology on December 4.
The team revealed that heterogeneous T-cell exhaustion status is determined by the differential PD-1 expression levels in CD8+ T cells in liver cancer patients. The authors found that tumor-infiltrating CD8+ T cells with high PD-1 expression from liver cancer patients are functionally impaired and co-express other immune checkpoint receptors such as TIM-3 and/or LAG3, compared to those with low PD-1 expression.
Moreover, based on these results, the authors suggested that liver cancer patients can be classified into two distinct subgroups. Patients having high PD-1 expression levels in the tumor microenvironment showed more aggressive tumor features and biomarkers predicting a favorable response to anti-PD1 therapy. The research team also demonstrated that only liver cancer patients having high PD-1 expression are susceptible to combined immune checkpoint blockade-based therapies.
Prof. Park said, “The new classification of liver cancer patients identified by this study can be utilized as a biomarker to predict the response of current cancer immunotherapy targeting the PD-1 pathway.” He also said they will continue to conduct research on T-cell exhaustion and activation in various types of cancer, which could lead to a better understanding of T-cell response against cancer, thereby providing evidence for future cancer immunotherapy to achieve the ultimate goal to prolong the survival of cancer patients.
2018.12.18 View 5272 -
Reducing the Drag Force of a Moving Body Underwater
(from left: Professor Yeunwoo Cho and PhD Jaeho Chung)
Professor Yeunwoo Cho and his team from the Department of Mechanical Engineering developed new technology that reduces the drag force of a moving body in a still fluid by using the supercavitation phenomenon.
When a body moves in air, the frictional drag is lower than that of the same body moving in water. Therefore, the body that moves in water can reduce the drag significantly when it is completely enveloped in a gaseous cavity.
The team used compressed air to create so-called supercavitation, which is a phenomenon created by completely enveloping a body in a single large gaseous cavity. The drag force exerted on the body is then measured.
As a result, the team confirmed that the drag force for a moving body enveloped in air is about 25% of the drag force for a moving body without envelopment.
These results can be applied for developing high-speed underwater vehicles and the development of air-lubricated, high-speed vessels.
The team expects that the results can be applied for developing high-speed underwater vehicles and the development of air lubrication for a ship’s hull.
This research, led by PhD Jaeho Chung, was published in the Journal of Fluid Mechanics as a cover article on November 10, 2018.
Figure 1. The cover article of the Journal of Fluid Mechanics Vol. 854
2018.12.04 View 4316 -
KAIST Seals the Deal for Kenya KAIST Project
KAIST will participate in Kenya’s strategic economic development plan under the provision of a turnkey-based science and technology education consultancy for the establishment of the Kenya Advanced Institute of Science and Technology (Kenya KAIST).KAIST signed the contract on November 30 with the Konza Technopolis Development Authority to establish Kenya KAIST. Korea Eximbank will offer a 95 million USD loan to the Kenyan government for this project. The project will include the educational and architectural design and construction of Kenya KAIST. The campus will be constructed in the Konza Techno City nearby Nairobi by 2021, with the first batch of 200 graduate students starting classes in 2022. KAIST, in consortium with Samwoo and Sunjin architecture and engineering companies, will take the lead of the three-year project, with the kick-off ceremony planned at the end of next January in Nairobi. The Kenyan government plans to transform Kenya into a middle-income country under Vision 2030 through promoting science, technology, and innovation for national economic growth. Nicknamed Africa’s Silicon Savannah, Konza Techno City is a strategic science and technology hub to realize this vision. To this end, the medium-term plan set a goal to provide specialized research and training in various leading-edge engineering and advanced science fields.In the two-phase evaluation of the consultancy bidding, KAIST won preferred bidder status in the technical proposal evaluation, outbidding three other Korean consortia. Invited to the financial proposal bidding, the KAIST consortium successfully completed month-long contract negotiations with Kenya last week.KAIST will develop academic curricula for six initial departments (Mechanical Engineering, Electrical/Electronic Engineering, ICT Engineering, Chemical Engineering, Civil Engineering, and Agricultural Biotechnology), which will lay the ground work for engineering research and education in Kenya to meet emerging socioeconomic demands. In addition, KAIST will provide the education of basic sciences of math, physics, chemistry, and biology for students.It is also notable that the Kenyan government asked to develop an industry-academy cooperation program in Konza Techno City. It reflects the growing industrial needs of Kenya KAIST, which will be located in the center of the Konza Technopolis. It is anticipated that the technopolis will create 16,675 jobs in the medium term and over 200,000 after completion, positioning Kenya as an ICT hub within the region.KAIST also shares a similar history of establishment with Kenya KAIST, as it will be built with a foreign loan. KAIST, created by the Korean government in 1971 to drive the economic engine through advancement of science and technology with a six-million USD loan from USAID, has now become a donor institution that hands down science and technology education systems including the construction of campuses to underdeveloped countries.The successful case of KAIST has been benchmarked by many countries for years. For instance, KAIST set up the curriculum of the nuclear engineering program at the Khalifa University of Science and Technology in UAE in 2010. In China, Chongqing University of Technology is running its electrical engineering and computer science programs based on the educational systems and curricula offered by KAIST from 2015. In October, KAIST also signed an MOU with the Prince Mohammad Bin Salman College of Cyber Security, AI, and Advanced Technologies in Saudi Arabia to provide the undergraduate program for robotics.Among all these programs benchmarking KAIST, Kenya KAIST clearly stands out, for it is carrying out a turnkey-based project that encompasses every aspect of institution building ranging from educational curriculum development to campus construction and supervision.President Sung-Chul Shin is extremely excited about finalizing the deal, remarking, “It is of great significance that KAIST’s successful development model has carved out a unique path to becoming a global leading university that will benefit other countries. In only a half century, we have transitioned from a receiver to a donor institution, as the country itself has done.”“KAIST will spare no effort for Kenya KAIST to become a successful science and technology university that will play a crucial role in Kenya’s national development. I believe Kenya KAIST will be an exemplary case of an ODA (Official Development Assistance) project based on the development of science and technology to benefit underdeveloped countries,” he added.
2018.12.03 View 10027 -
From Concept to Reality: Changing Color of Light Using a Spatiotemporal Boundary
(from left: Professor Bumki Min, PhD candidate Jaehyeon Son and PhD Kanghee Lee)
A KAIST team developed an optical technique to change the color (frequency) of light using a spatiotemporal boundary. The research focuses on realizing a spatiotemporal boundary with a much higher degree of freedom than the results of previous studies by fabricating a thin metal structure on a semiconductor surface. Such a spatiotemporal boundary is expected to be applicable to an ultra-thin film type optical device capable of changing the color of light.
The optical frequency conversion device plays a key role in precision measurement and communication technology, and the device has been developed mainly based on optical nonlinearity.
If the intensity of light is very strong, the optical medium responds nonlinearly so the nonlinear optical phenomena, such as frequency doubling or frequency mixing, can be observed. Such optical nonlinear phenomena are realized usually by the interaction between a high-intensity laser and a nonlinear medium.
As an alternative method frequency conversion is observed by temporally modifying the optical properties of the medium through which light travels using an external stimulus. Since frequency conversion in this way can be observed even in weak light, such a technique could be particularly useful in communication technology.
However, rapid optical property modification of the medium by an external stimulus and subsequent light frequency conversion techniques have been researched only in the pertubative regime, and it has been difficult to realize these theoretical results in practical applications.
To realize such a conceptual idea, Professor Bumki Min from the Department of Mechanical Engineering and his team collaborated with Professor Wonju Jeon from the Department of Mechanical Engineering and Professor Fabian Rotermund from the Department of Physics. They developed an artificial optical material (metamaterial) by arranging a metal microstructure that mimics an atomic structure and succeeded in creating a spatiotemporal boundary by changing the optical property of the artificial material abruptly.
While previous studies only slightly modified the refractive index of the medium, this study provided a spatiotemporal boundary as a platform for freely designing and changing the spectral properties of the medium. Using this, the research team developed a device that can control the frequency of light to a large degree.
The research team said a spatiotemporal boundary, which was only conceptually considered in previous research and realized in the pertubative regime, was developed as a step that can be realized and applied.
Professor Min said, “The frequency conversion of light becomes designable and predictable, so our research could be applied in many optical applications. This research will present a new direction for time-variant media research projects in the field of optics.”
This research, led by PhD Kanghee Lee and PhD candidate Jaehyeon Son, was published online in Nature Photonics on October 8, 2018.
This work was supported by the National Research Foundation of Korea (NRF) through the government of Korea. The work was also supported by the Center for Advanced Meta-Materials (CAMM) funded by the Korea Government (MSIP) as the Global Frontier Project (NRF-2014M3A6B3063709).
Figure 1. The frequency conversion process of light using a spatiotemporal boundary.
Figure 2. The complex amplitude of light at the converted frequency with the variation of a spatiotemporal boundary.
2018.11.29 View 8112