Global
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An Electron Cloud Distribution Observed by the Scanning Seebeck Microscope
All matters are made of small particles, namely atoms. An atom is composed of a heavy nucleus and cloud-like, extremely light electrons.
Korean researchers developed an electron microscopy technique that enables the accurate observation of an electron cloud distribution at room-temperature. The achievement is comparable to the invention of the quantum tunneling microscopy technique developed 33 years ago.
Professor Yong-Hyun Kim of the Graduate School of Nanoscience and Technology at KAIST and Dr. Ho-Gi Yeo of the Korea Research Institute of Standards and Science (KRISS) developed the Scanning Seebeck Microscope (SSM). The SSM renders clear images of atoms, as well as an electron cloud distribution. This was achieved by creating a voltage difference via a temperature gradient.
The development was introduced in the online edition of Physical Review Letters (April 2014), a prestigious journal published by the American Institute of Physics.
The SSM is expected to be economically competitive as it gives high resolution images at an atomic scale even for graphene and semiconductors, both at room temperature. In addition, if the SSM is applied to thermoelectric material research, it will contribute to the development of high-efficiency thermoelectric materials.
Through numerous hypotheses and experiments, scientists now believe that there exists an electron cloud surrounding a nucleus. IBM's Scanning Tunneling Microscope (STM) was the first to observe the electron cloud and has remained as the only technique to this day. The developers of IBM microscope, Dr. Gerd Binnig and Dr. Heinrich Rohrer, were awarded the 1986 Nobel Prize in Physics.
There still remains a downside to the STM technique, however: it required high precision and extreme low temperature and vibration. The application of voltage also affects the electron cloud, resulting in a distorted image.
The KAIST research team adopted a different approach by using the Seebeck effect which refers to the voltage generation due to a temperature gradient between two materials.
The team placed an observation sample (graphene) at room temperature (37~57℃) and detected its voltage generation. This technique made it possible to observe an electron cloud at room temperature.
Furthermore, the research team investigated the theoretical quantum mechanics behind the electron cloud using the observation gained through the Seebeck effect and also obtained by simulation capability to analyze the experimental results.
The research was a joint research project between KAIST Professor Yong-Hyun Kim and KRISS researcher Dr. Ho-Gi Yeo. Eui-Seop Lee, a Ph.D. candidate of KAIST, and KRISS researcher Dr. Sang-Hui Cho also participated. The Ministry of Science, ICT, and Future Planning, the Global Frontier Initiative, and the Disruptive Convergent Technology Development Initiative funded the project in Korea.
Picture 1: Schematic Diagram of the Scanning Seebeck Microscope (SSM)
Picture 2: Electron cloud distribution observed by SSM at room temperature
Picture 3: Professor Yong-Hyun Kim
2014.04.04 View 12920 -
High Resolution 3D Blood Vessel Endoscope System Developed
Professor Wangyeol Oh of KAIST’s Mechanical Engineering Department has succeeded in developing an optical imaging endoscope system that employs an imaging velocity, which is up to 3.5 times faster than the previous systems. Furthermore, he has utilized this endoscope to acquire the world’s first high-resolution 3D images of the insides of in vivo blood vessel.
Professor Oh’s work is Korea’s first development of blood vessel endoscope system, possessing an imaging speed, resolution, imaging quality, and image-capture area. The system can also simultaneously perform a functional imaging, such as polarized imaging, which is advantageous for identifying the vulnerability of the blood vessel walls.
The Endoscopic Optical Coherence Tomography (OCT) System provides the highest resolution that is used to diagnose cardiovascular diseases, represented mainly by myocardial infarction.
However, the previous system was not fast enough to take images inside of the vessels, and therefore it was often impossible to accurately identify and analyze the vessel condition. To achieve an in vivo blood vessel optical imaging in clinical trials, the endoscope needed to be inserted, after which a clear liquid flows instantly, and pictures can be taken in only a few seconds.
The KAIST research team proposed a solution for such problem by developing a high-speed, high-resolution optical tomographic imaging system, a flexible endoscope with a diameter of 0.8 mm, as well as a device that can scan the imaging light within the blood vessels at high speed. Then, these devices were combined to visualize the internal structure of the vessel wall.
Using the developed system, the researchers were able to obtain high-resolution images of about 7 cm blood vessels of a rabbit’s aorta, which is similar size to human’s coronary arteries. The tomography scan took only 5.8 seconds, at a speed of 350 scans per second in all three directions with a resolution of 10~35㎛.
If the images are taken every 200 ㎛, like the currently available commercial vascular imaging endoscopes, a 7cm length vessel can be imaged in only one second.
Professor Wangyeol Oh said, “Our newly developed blood vessel endoscope system was tested by imaging a live animal’s blood vessels, which is similar to human blood vessels. The result was very successful.”
“Collaborating closely with hospitals, we are preparing to produce the imaging of an animal’s coronary arteries, which is similar in size to the human heart,” commented Professor Oh on the future clinical application and commercialization of the endoscope system. He added, “After such procedures, the technique can be applied in clinical patients within a few years.”
Professor Oh’s research was supported by the National Research Foundation of Korea and the Global Frontier Project by the Korean government. The research results were published in the 2014 January’s edition of Biomedical Optics Express.
Figure 1: End portion of optical endoscope (upper left)
Figure 2: High-speed optical scanning unit of the endoscope (top right)
Figure 3: High-resolution images of the inside of in vivo animal blood vessels (in the direction of vascular circumference and length)
Figure 4: High-resolution images of the inside of in vivo animal blood vessels (in the direction of the vein depth)
2014.03.25 View 10227 -
Quacquarelli Symonds (QS) World University Rankings by Subject 2014
The QS
World University Rankings are annual university rankings published by
Quacquarelli Symonds (QS) which provides the overall rankings of top global
universities as well as the rankings for individual subjects. The 2014 QS World
University Rankings by Subject is a comprehensive guide to the world’s best universities
in 30 popular subjects of 5 academic disciplines: arts & humanities,
engineering & technology, life sciences & medicine, natural sciences,
and social sciences.
According
to the 2014 subject rankings, released on February 26, KAIST made the list of top
50 universities in 9 subjects: physics & astronomy; materials sciences;
chemistry; chemical engineering; mechanical, aeronautical & manufacturing
engineering; electrical & electronic engineering; civil & structural engineering;
computer science & information systems; and biological sciences.
Among
them, KAIST was ranked number one in Korea for 5 subjects: materials sciences
(16th); mechanical, aeronautical & manufacturing engineering (21st);
civil & structural engineering (32nd); computer science &
information systems (36th), and biological sciences (43rd).
For basic sciences, KAIST has made good progress as well. For example, in
mathematics, KAIST took first place in Korea and was ranked in the 51st-100th
of the world’s top universities. Another notable result was that its business college
in Seoul campus, a relatively new addition to KAIST, made the rankings list of
51st-100th in accounting & finance.
The 2014
QS subject rankings used the following criteria for its evaluation of
university performance: a survey of academic and employer reputation, citations
per paper, inclusion of specialists, and the h-index, known as the Hirsch index or Hirsch number, which was
suggested by Jorge E. Hirsch, a physicist at the University of California in
San Diego, as a tool for determining theoretical physicists’ relative quality.
Today, the h-index is used to measure
both the productivity and impact of the published work of a scientist or
scholar.
2014.02.28 View 10358 -
KAIST Participates in the 2014 Davos Forum on January 22-25 in Switzerland
Through the sessions of the Global University Leaders Forum, IdeasLab, and Global Agenda Councils on Biotechnology, KAIST participants will actively engage with global leaders in the discussion of issues on education innovation and technological breakthroughs.
The 2014 Annual Meeting of the World Economic Forum (WEF), known as the Davos Forum, will kick off on January 22-25 in Davos-Klosters, Switzerland, under the theme of "The Reshaping of the World: Consequences for Society, Politics, and Business." Each year, the Forum attracts about 2,500 distinguished leaders from all around the world and provides an open platform to identify the current and emerging challenges facing the global community and to develop ideas and actions necessary to respond to such challenges.
President Sung-Mo Steve Kang and Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering, KAIST, will attend the Forum and engage in a series of dialogues on such issues as Massive Open Online Courses, new paradigms for universities and researchers, the transformation of higher education, the role and value of scientific discoveries, and the impact of biotechnology on the future of society and business.
At the session entitled "New Paradigms for Universities of the Future" hosted by the Global University Leaders Forum (GULF), President Kang will introduce KAIST"s ongoing online education program, Education 3.0. GULF was created in 2006 by WEF, which is a small community of the presidents and senior representatives of the top universities in the world.
Implemented in 2012, Education 3.0 incorporates advanced information and communications technology (ICT) to offer students and teachers a learner-based, team-oriented learning and teaching environment. Under Education 3.0, students study online and meet in groups with a professor for in-depth discussions, collaboration, and problem-solving. KAIST plans to expand the program to embrace the global community in earnest by establishing Education 3.0 Global in order to have interactive real-time classes for students and researchers across regions and cultures.
President Kang will also present a paper entitled "Toward Socially Responsible Technology: KAIST"s Approach to Integrating Social and Behavioral Perspectives into Technology Development" at another session of GULF called "Seeking New Approaches to Critical Global Challenges." In the paper, President Kang points out that notwithstanding the many benefits we enjoy from the increasingly interconnected world, digital media may pose a threat to become a new outlet for social problems, for example, Internet or digital addiction.
Experts say that early exposure to digital devices harms the healthy development of cognitive functions, emotions, and social behavior. President Kang will introduce KAIST"s recent endeavor to develop a non-intrusive technology to help prevent digital addiction, which will ultimately be embedded in the form of a virtual coach or mentor that helps and guides people under risk to make constructive use of digital devices. President Kang stresses the fundamental shift in the science and technology development paradigm from research and development (R&D) to a research and solution development (R&SD), taking serious consideration of societal needs, quality of life, and social impacts when conducting research.
Professor Sang Yup Lee will moderate the IdeasLab session at the Davos Forum entitled "From Lab to Life with the California Institute of Technology (Caltech)." Together with scientists from Caltech, he will discuss scientific breakthroughs that transform institutions, industries, and individuals in the near future, such as the development of damage-tolerant lightweight materials with nanotechnology, the ability to read and write genomes, and wireless lab-in-the-body monitors. In addition, he will meet global business leaders at the session of "Sustainability, Innovation, and Growth" and speak about how emerging technologies, biotechnology in particular, will transform future societies, business, and industries.
As a current special adviser of the World Economic Forum"s (WEF) Chemicals Industry Community, Professor Lee will meet global chairs and chief executive officers of chemical companies and discuss ways to advance the industry to become more bio-based and environmentally friendly. He served as a founding chairman of WEF"s Global Agenda Councils on Biotechnology in 2013.
President Sung-Mo Steve Kang Distinguished Professor Sang Yup Lee
2014.01.17 View 10042 -
First International Conference on Science and Technology for Society
KAIST co-organized the 2013 International Conference on Science and Technology for Society which was held on November 28 at the Grace Hall in Seoul EL-Tower. More than 300 people, including members of the Global Social Technology Advisory Board, domestic social technology experts, private companies, government officials, private citizens, and students joined the conference to discuss the roles and responsibilities of science and technology for society.
R&D policies and technologies for solving social issues were introduced, and discussions were held on desirable directions for technological development.
The first speaker, Yasushi Watanabe, Director of RISTEX (Research Institute of Science and Technology for Society) in Japan, introduced the importance of science and technology for society under the title “Change of R&D Paradigm for Society.”
Robert Wimmer, GrAT (Center for Appropriate Technology), Vienna University of Technology in Austria, presented “Need-oriented Design & Solutions for Development.” Kiyoaki Murakami, MRI, Japan, presented “Introduction of Platinum Vision” and Robert Ries, University of Florida, U.S.A., presented “Evaluating the Social Impacts of the Built Environment Using Life Cycle Assessment.”
Case studies on social enterprises and presentations on R&D for solving social problems were introduced by ICISTS (International Conference for the Integration of Science, Technology and Society), which is a student group at KAIST, National Research Foundation of Korea (NRF), Korea Institute of Machinery and Materials (KIMM), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea Institute of Industrial Technology (KITECH), Electronics and Telecommunication Research Institute (ETRI), and Korea Research Institute of Chemical Technology (KRICT).The conference was hosted by the Ministry of Science, ICT, and Future Planning and co-organized by NRF, KIMM, KRIBB, KITECH, ETRI and KRICT.
2013.12.11 View 10060 -
President of WIPA Sang-Hui Lee and SK Hynix Awarded the 2013 Intellectual Property Award
The ceremony for the 3rd Intellectual Property Award was held at the KAIST campus in Seoul on November 2nd. The award is given annually to Korean practitioners in intellectual property.
This year’s recipients were Sang-Hui Lee, the president of the World Intellectual Property Association of Korean Practitioners (WIPA) and the SK Hynix Patent Group which successfully defended a long-lasting claim against a patent specialist corporation.
The Intellectual Property Award (IP Award) is presented in recognition to Korean individuals or groups that contributed to national competitiveness through creation, application, or proceedings of intellectual property, as well as to building the foundation for the protection of patents, intellectual properties, and trademarks.
President Lee successfully hosted the Global Intellectual Property Summit in Seoul, which was held in October 2012. He was a crucial force behind the foundation of WIPA in May of this year and was also elected as the first president for the organization. Recently, President Lee has been at the forefront of job creation through the efficient use of intellectual property and the creative discovery of venture endeavors.
President Lee said, “The unique characteristic of a knowledge-based society lies in the collaboration network of people and knowledge property, startups based on intellectual property, and decentralized development.”
He added, “Just as Finland adopted a policy to build venture companies in utilization of intellectual properties and encouraged the decentralized growth throughout the nation after the collapse of Nokia, Korea must adapt to meet the changing requirements of the knowledge-intensive era.”
The SK Hynix Patent Group, another recipient for the Intellectual Property Award, won the lawsuit, dragged on for 13 years, against the Rambus, an American patent specialized corporation. The group initially lost the first trial in the federal court of California, but through relentless research and efforts, they won the case in the appeals court. The IP Award was co-hosted by the Korea Patent Attorney Association, the Korea Intellectual Property and Service Association, and KAIST.
2013.11.21 View 8311 -
The World Economic Forum Invites KAIST to 2014 Davos Forum
President Steve Kang and Distinguished Professor Sang Yup Lee have been invited by the World Economic Forum (WEF) to attend its annual meeting slated for January 22-25, 2014 in Davos-Klosters, Switzerland.
The president will also join the Global University Leaders Forum (GULF) to be held during the annual meeting. The GULF consists of leading research universities throughout the world, at which President Kang will address agenda related to higher education and research.
From September 11th to 13th, KAIST was invited to the WEF’s 2013 Summer Davos Forum held in Dalian, China. The Summer Davos Forum is recognized as a barometer of the world economy, and KAIST hosted three sessions there.
In a session titled “Smart Regulations,” Professor Sang Yup Lee hosted presentations and discussions under the topic of “How regulation models can strengthen technical innovation and expansion.” President Steve Kang, Peter Sands, CEO of Standard Chartered Bank Group, Mark Weinberger, CEO of Ernest & Young, and Peter Terium, CEO of RWE, participated in the discussions.
The KAIST delegates also presented and participated in a session titled “From Trade Center to Innovative Hub” to discuss how to lead innovations in Asia, as well as “Marine Resources: Finding New Frontier” to address issues of how to develop and manage oceanic resources for potential growth.
President Kang said, “The World Economic Forum allows us to introduce the results of our innovative and creative research to global leaders and to demonstrate that our global position continues to grow.”
The WEF has been hosting Summer Davos Forum in China since 2007. About 1,500 participants from over 90 countries joined in this year’s summer forum under the theme of “Innovation: Inevitable Mainstream.” New strategies for innovations and solutions for global threats were suggested through presentations and discussions in 125 sessions.
The World Economic Forum (WEF) is an independent, international, and non-profit organization based in Geneva, Switzerland. It is committed to improving the state of the world by engaging business, political, academic, and government leaders to shape global, regional and industry agenda.
Among the meetings and forums organized by the WEF, its annual meeting held each January in Davos, a.k.a. the Davos Forum, has been the best known gathering. The Davos Forum brings together some 2,500 top business leaders, international political leaders, selected intellectuals and journalists to discuss the most pressing issues facing the world including health and environment.
2013.11.07 View 10160 -
KAIST's classes now available to take from all around the world
Signed a partnership agreement with Coursera to provide millions of people with online courses in science and technology.
The Korea Advanced Institute of Science and Technology (KAIST), a world-leading research university focusing on science, engineering and technology, joined a new, online platform for open access that serves the needs of Korean and global learners.
KAIST and Coursera, the world"s largest provider of massive open online courses (MOOCs), agreed on October 14th, 2013 to partner for the provision of internet-based open learning, through which the university expects to reinforce its current education initiative, Education 3.0.Steve Kang, president of KAIST, was upbeat about the partnership."We know the benefits and importance of online education that will significantly impact the landscape of today"s higher education. Hopefully, our partnership with Coursera will expand our initiative to continuously provide quality education globally."
With its network of 107 prestigious partner universities and public institutions worldwide, Coursera offers 482 free online courses across a wide field of humanities, science, engineering, and business to 5 million students around the globe.
KAIST will be able to utilize top-notch online courses and lecture contents available on the company"s website. The university can also supply its online courses to the global community, allowing the faculty"s top quality lectures to reach hundreds and thousands of students and adult learners throughout the world.Incorporating advanced information and communications technology, KAIST has implemented a new, smart education program, Education 3.0, since 2012 to effectively meet the growing demands of creating a better and more interactive learning and teaching environment for students and faculty. Under Education 3.0, students study online and meet in groups with a professor for discussions and problem solving.
Tae-Eog Lee, Director of the Center for Excellence in Learning & Teaching at KAIST, said:"We received a phenomenal response from students and professors to the courses made available under Education 3.0. For this year alone, we are offering 60 courses, such classes as calculus, general biology, basic programming, design and communication, bioengineering fundamentals, and logic and artificial intelligence."
Professor Lee added:"It has turned out that our education initiative is not only useful to our students but also quite popular among learners outside the university and Korea. It"s a great thing that KAIST can contribute to the world"s concerted efforts to provide equal opportunities for learning. At the same time, we look forward to seeing the benefits of MOOC-based content being used in our classrooms."
Founded in 2012 by two eminent Stanford University professors, Coursera has held a strong lead in MOOCs. Unlike the traditional online education model, open courseware (OCW), designed for simply sharing lecture materials including videos, slides, and data through the internet, MOOCs develop and evaluate courses, lecture contents, and delivery quality to meet high academic standards—In order to earn credits, subscribers (universities and students) are required to submit course registration, specification, and description; student attendance roster; homework and assignments; and assessment.
Daphne Koller, co-founder of Coursera, commented on the partnership agreement with KAIST:"We are honored to have so many brilliant minds working together to expand educational opportunities globally. To be able to offer courses from professors at the forefront of their fields to millions of people is truly remarkable, and our students remind us daily of the value of spreading this knowledge globally."
Among the partner universities and institutions are Stanford University, California Institute of Technology, Columbia University, École Polytechnique Fédérale de Lausanne, Technion-Israel Institute of Technology, the National University of Singapore, the University of Tokyo, the World Bank, and Shanghai Jiao Tong University.
President Steve Kang (in the left) singed a partnership agreement with Dr. Daphne Koller (in the right), president and CEO of Coursera.
2013.11.04 View 9189 -
Foreign graduates donate to development fund for six years
International graduates of the Global IT Technology Graduate School at KAIST have continued a tradition of giving something back to their alma mater.
On May 10th, President Steve Kang held a donation ceremony with 12 donors.
Started in 2008, the graduates, mostly consisted of government officials from developing countries, have raised a development fund for KAIST, and in the past six years, a total of 81 graduates donated USD 10,000.
“KAIST provided me with an excellent education and research environment during my studies. I’m glad that I can have an opportunity to help my juniors and the university,” said Naryn Kenzhaliyev of Kazakhstan, a graduate present at the ceremony.
“Every year, these students voluntarily give when they are about to graduate. We feel proud and greatly appreciated for their philanthropic efforts,” said Professor Jae-Jung Noh, responsible for the global IT technology graduate program.
Established in 2006, the Global IT Technology Graduate School has attracted IT specialists from Korea and abroad, offering master’s and doctoral degrees. The school has invited many public servants in developing countries whose expertise lies in IT technology.
2013.07.04 View 5945 -
Top Ten Ways Biotechnology Could Improve Our Everyday Life
The Global Agenda Council on Biotechnology, one of the global networks under the World Economic Forum, which is composed of the world’s leading experts in the field of biotechnology, announced on February 25, 2013 that the council has indentified “ten most important biotechnologies” that could help meet rapidly growing demand for energy, food, nutrition, and health. These new technologies, the council said, also have the potential to increase productivity and create new jobs.
“The technologies selected by the members of the Global Agenda Council on Biotechnology represent almost all types of biotechnology.Utilization of waste, personalized medicine,and ocean agricultureare examples of the challenges where biotechnology can offer solutions,”said Sang Yup Lee, Chair of the Global Agenda Council on Biotechnology and Distinguished Professor in the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST). He also added that “the members of the council concluded that regulatory certainty, public perception, and investment are the key enablers for the growth of biotechnology.”
These ideas will be further explored during “Biotechnology Week” at the World Economic Forum’s Blog (http://wef.ch/blog) from Monday, 25 February, 2013. The full list follows below:
Bio-based sustainable production of chemicals, energy, fuels and materials
Through the last century, human activity has depleted approximately half of the world’s reserves of fossil hydrocarbons. These reserves, which took over 600 million years to accumulate, are non-renewable and their extraction, refining and use contribute significantly to human emissions of greenhouse gases and the warming of our planet. In order to sustain human development going forward, a carbon-neutral alternative must be implemented. The key promising technology is biological synthesis; that is, bio-based production of chemicals, fuels and materials from plants that can be re-grown.
Engineering sustainable food production
The continuing increase in our numbers and affluence are posing growing challenges to the ability of humanity to produce adequate food (as well as feed, and now fuel). Although controversial, modern genetic modification of crops has supported growth in agricultural productivity. In 2011, 16.7 million farmers grew biotechnology-developed crops on almost 400 million acres in 29 countries, 19 of which were developing countries. Properly managed, such crops have the potential to lower both pesticide use and tilling which erodes soil.
Sea-water based bio-processes
Over 70% of the earth surface is covered by seawater, and it is the most abundant water source available on the planet. But we are yet to discover the full potential of it. For example with halliophic bacteria capable of growing in the seawater can be engineered to grow faster and produce useful products including chemicals, fuels and polymeric materials. Ocean agriculture is also a promising technology. It is based on the photosynthetic biomass from the oceans, like macroalgae and microalgae.
Non-resource draining zero waste bio-processing
The sustainable goal of zero waste may become a reality with biotechnology. Waste streams can be processed at bio-refineries and turned into valuable chemicals and fuels, thereby closing the loop of production with no net waste. Advances in biotechnology are now allowing lower cost, less draining inputs to be used, including methane, and waste heat. These advances are simplifying waste streams with the potential to reduce toxicity as well as support their use in other processes, moving society progressively closer to the sustainable goal of zero waste.
Using carbon dioxide as a raw material
Biotechnology is poised to contribute solutions to mitigate the growing threat of rising CO2 levels. Recent advances are rapidly increasing our understanding of how living organisms consume and use CO2. By harnessing the power of these natural biological systems, scientists are engineering a new wave of approaches to convert waste CO2 and C1 molecules into energy, fuels, chemicals, and new materials.
Regenerative medicine
Regenerative medicine has become increasingly important due to both increased longevity and treatment of injury. Tissue engineering based on various bio-materials has been developed to speed up the regenerative medicine. Recently, stem cells, especially the induced pluripotent stem cells (iPS), have provided another great opportunity for regenerative medicine. Combination of tissue engineering and stem cell (including iPS) technologies will allow replacements of damaged or old human organs with functional ones in the near future.
Rapid and precise development and manufacturing of medicine and vaccines
A global pandemic remains one of the most real and serious threats to humanity. Biotechnology has the potential to rapidly identify biological threats, develop and manufacture potential cures. Leading edge biotechnology is now offering the potential to rapidly produce therapeutics and vaccines against virtually any target. These technologies, including messenger therapeutics, targeted immunotherapies, conjugated nanoparticles, and structure-based engineering, have already produced candidates with substantial potential to improve human health globally.
Accurate, fast, cheap, and personalized diagnostics and prognostics
Identification of better targets and combining nanotechnology and information technology it will be possible to develop rapid, accurate, personalized and inexpensive diagnostics and prognostics systems.
Bio-tech improvements to soil and water
Arable land and fresh water are two of the most important, yet limited, resources on earth. Abuse and mis-appropriation have threatened these resources, as the demand on them has increased. Advances in biotechnology have already yielded technologies that can restore the vitality and viability of these resources. A new generation of technologies: bio-remediation, bio-regeneration and bio-augmentation are being developed, offering the potential to not only further restore these resources, but also augment their potential.
Advanced healthcare through genome sequencing
It took more than 13 years and $1.5 billion to sequence the first human genome and today we can sequence a complete human genome in a single day for less than $1,000. When we analyze the roughly 3 billion base pairs in such a sequence we find that we differ from each other in several million of these base pairs. In the vast majority of cases these difference do not cause any issues but in rare cases they cause disease, or susceptibility to disease. Medical research and practice will increasingly be driven by our understanding of such genetic variations together with their phenotypic consequences.
2013.03.19 View 10968 -
KAIST and Saudi Aramco agreed to establish a joint CO2 research center in Korea
The Korea Advanced Institute of Science and Technology (KAIST) and Saudi Aramco, a global energy and petrochemicals enterprise, signed a memorandum of understanding (MOU) on January 6, 2013 in Dhahran, Saudi Arabia and pledged to jointly collaborate in research and development of innovative technologies and solutions to address the world"s energy challenges.
Under the MOU, the two entities agreed to establish a research center, Saudi Aramco-KAIST CO2 Research Center, near KAIST"s main campus in Daejeon, Korea. The research center, to be jointly managed by KAIST and Saudi Aramco, will foster and facilitate research collaborations in areas such as tackling carbon dioxide (CO2) emissions by removal or capture of CO2, conversing CO2 into useful products, developing efficiency improvements in energy production, sharing carbon management technologies, establishing exchange programs, and conducting joint projects.
According to Saudi Aramco, the company"s collaboration with KAIST is the first partnership established in Asia. Khalid A. Al-Falih, President and CEO of Saudi Aramco, said,
"The CO2 Research Center represents a major step in Saudi Aramco"s research and technology strategy to partner with top global institutions to help address and find sustainable solutions to the world’s energy challenge both domestically and internationally."
2013.03.19 View 9131
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New BioFactory Technique Developed using sRNAs
Professor Sang Yup Lee
- published on the online edition of Nature Biotechnology. “Expected as a new strategy for the bio industry that may replace the chemical industry.”-
KAIST Chemical & Biomolecular engineering department’s Professor Sang Yup Lee and his team has developed a new technology that utilizes the synthetic small regulatory RNAs (sRNAs) to implement the BioFactory in a larger scale with more effectiveness.
* BioFactory: Microbial-based production system which creates the desired compound in mass by manipulating the genes of the cell.
In order to solve the problems of modern society, such as environmental pollution caused by the exhaustion of fossil fuels and usage of petrochemical products, an eco-friendly and sustainable bio industry is on the rise. BioFactory development technology has especially attracted the attention world-wide, with its ability to produce bio-energy, pharmaceuticals, eco-friendly materials and more.
For the development of an excellent BioFactory, selection for the gene that produces the desired compounds must be accompanied by finding the microorganism with high production efficiency; however, the previous research method had a complicated and time-consuming problem of having to manipulate the genes of the microorganism one by one.
Professor Sang Yup Lee’s research team, including Dr. Dokyun Na and Dr. Seung Min Yoo, has produced the synthetic sRNAs and utilized it to overcome the technical limitations mentioned above.
In particular, unlike the existing method, this technology using synthetic sRNAs exhibits no strain specificity which can dramatically shorten the experiment that used to take months to just a few days.
The research team applied the synthetic small regulatory RNA technology to the production of the tyrosine*, which is used as the precursor of the medicinal compound, and cadaverine**, widely utilized in a variety of petrochemical products, and has succeeded developing BioFactory with the world’s highest yield rate (21.9g /L, 12.6g / L each).
*tyrosine: amino acid known to control stress and improve concentration
**cadaverine: base material used in many petrochemical products, such as polyurethane
Professor Sang Yup Lee highlighted the significance of this research: “it is expected the synthetic small regulatory RNA technology will stimulate the BioFactory development and also serve as a catalyst which can make the chemical industry, currently represented by its petroleum energy, transform into bio industry.”
The study was carried out with the support of Global Frontier Project (Intelligent Bio-Systems Design and Synthesis Research Unit (Chief Seon Chang Kim)) and the findings have been published on January 20th in the online edition of the worldwide journal Nature Biotechnology.
2013.02.21 View 9896