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Discovery of an Optimal Drug Combination: Overcoming Resistance to Targeted Drugs for Liver Cancer
A KAIST research team presented a novel method for improving medication treatment for liver cancer using Systems Biology, combining research from information technology and the life sciences. Professor Kwang-Hyun Cho in the Department of Bio and Brain Engineering at KAIST conducted the research in collaboration with Professor Jung-Hwan Yoon in the Department of Internal Medicine at Seoul National University Hospital. This research was published in Hepatology in September 2017 (available online from August 24, 2017).
Liver cancer is the fifth and seventh most common cancer found in men and women throughout the world, which places it second in the cause of cancer deaths. In particular, Korea has 28.4 deaths from liver cancer per 100,000 persons, the highest death rate among OECD countries and twice that of Japan.
Each year in Korea, 16,000 people get liver cancer on average, yet the five-year survival rate stands below 12%. According to the National Cancer Information Center, lung cancer (17,399) took the highest portion of cancer-related deaths, followed by liver cancer (11,311) based on last year data.
Liver cancer is known to carry the highest social cost in comparison to other cancers and it causes the highest fatality in earlier age groups (40s-50s). In that sense, it is necessary to develop a new treatment that mitigates side effects yet elevates the survival rate.
There are ways in which liver cancer can be cured, such as surgery, embolization, and medication treatments; however, the options become limited for curing progressive cancer, a stage in which surgical methods cannot be executed.
Among anticancer medications, Sorafenib, a drug known for enhancing the survival rate of cancer patients, is a unique drug allowed for use as a targeted anticancer medication for progressive liver cancer patients. Its sales reached more than ten billion KRW annually in Korea, but its efficacy works on only about 20% of the treated patients. Also, acquired resistance to Sorafenib is emerging. Additionally, the action mechanism and resistance mechanism of Sorafenib is only vaguely identified.Although Sorafenib only extends the survival rate of terminal cancer patients less than three months on average, it is widely being used because drugs developed by global pharmaceutical companies failed to outperform its effectiveness.
Professor Cho’s research team analyzed the expression changes of genes in cell lines in response to Sorafenib in order to identify the effect and the resistance mechanism of Sorafenib.
As a result, the team discovered the resistance mechanism of Sorafenib using Systems Biology analysis. By combining computer simulations and biological experiments, it was revealed that protein disulfide isomerase (PDI) plays a crucial role in the resistance mechanism of Sorafenib and that its efficacy can be improved significantly by blocking PDI.
The research team used mice in the experiment and discovered the synergic effect of PDI inhibition with Sorafenib for reducing liver cancer cells, known as hepatocellular carcinoma. Also, more PDIs are shown in tissue from patients who possess a resistance to Sorafenib. From these findings, the team could identify the possibility of its clinical applications. The team also confirmed these findings from clinical data through a retrospective cohort study.
“Molecules that play an important role in cell lines are mostly put under complex regulation. For this reason, the existing biological research has a fundamental limitations for discovering its underlying principles,” Professor Cho said. “This research is a representative case of overcoming this limitation of traditional life science research by using a Systems Biology approach, combining IT and life science. It suggests the possibility of developing a new method that overcomes drug resistance with a network analysis of the targeted drug action mechanism of cancer.”
The research was supported by the National Research Foundation of Korea (NRF) and funded by the Ministry of Science and ICT.
(Figure 1. Simulation results from cellular experiments using hepatocellular carcinoma)
(Figure 2. Network analysis and computer simulation by using the endoplasmic reticulum (ER) stress network)
(Figure 3. ER stress network model)
2017.08.30 View 10456 -
Cooperative Tumor Cell Membrane-Targeted Phototherapy
A KAIST research team led by Professor Ji-Ho Park in the Bio and Brain Engineering Department at KAIST developed a technology for the effective treatment of cancer by delivering synthetic receptors throughout tumor tissue. The study, led by Ph.D. candidate Heegon Kim, was published online in Nature Communications on June 19.
Cancer targeted therapy generally refers to therapy targeting specific molecules that are involved in the growth and generation of cancer. The targeted delivery of therapeutics using targeting agents such as antibodies or nanomaterials has improved the precision and safety of cancer therapy.
However, the paucity and heterogeneity of identified molecular targets within tumors have resulted in poor and uneven distribution of targeted agents, thus compromising treatment outcomes.
To solve this problem, the team constructed a cooperative targeting system in which synthetic and biological nanocomponents participate together in the tumor cell membrane-selective localization of synthetic receptors to amplify the subsequent targeting of therapeutics. Here, synthetic and biological nanocomponents refer to liposomes and extracellular vesicles, respectively.
The synthetic receptors are first delivered selectively to tumor cell membranes in the perivascular region using liposomes. By hitchhiking with extracellular vesicles secreted by the cells, the synthetic receptors are transferred to neighboring cells and further spread throughout the tumor tissues where the molecular targets are limited.
Hitchhiking extracellular vesicles for delivery of synthetic receptors was possible since extracellular vesicles, such as exosomes, mediate intercellular communications by transferring various biological components such as lipids, cytosolic proteins, and RNA through a membrane fusion process. They also play a supportive role in promoting tumor progression in that tumor-derived extracellular vesicles deliver oncogenic signals to normal host cells.
The team showed that this tumor cell membrane-targeted delivery of synthetic receptors led to a uniform distribution of synthetic receptors throughout a tumor and subsequently led to enhanced phototherapeutic efficacy of the targeted photosensitizer.
Professor Park said, “The cooperative tumor targeting system is expected to be applied in treating various diseases that are hard to target.”
The research was funded by the Basic Science Research Program through the National Research Foundation funded by the Ministry of Science, ICT & Future Planning, and the National R&D Program for Cancer Control funded by the Ministry for Health and Welfare.
(Ph.D. candidates Hee Gon Kim (left) and Chanhee Oh)
Figure 1. A schematic of a cooperative tumor targeting system via delivery of synthetic receptors.
Figure 2. A confocal microscopic image of a tumor section after cooperative targeting by synthetic receptor delivery. Green and magenta represent vessels and therapeutic agents inside a tumor respectively.
2017.07.07 View 9569 -
The 2017 International Food Festival
The savory smell of exotic dishes filled the main plaza of the KAIST campus on May 26. Exotic music reverberated throughout the campus. The KAIST community took a break together on a breezy early summer Friday afternoon sharing food with their friends and family. KAIST international student body, KISA (KAIST International Students Association), installed white food tents and prepared their country’s favorite dishes at their 13th annual International Food Festival.
The festival was co-organized with Chungnam National University and the University of Science & Technology (UST). At the festival, students from 18 nations cooked about 60 dishes and sold them to the public. Foreign students’ performances of traditional dance and music on the stage livened the atmosphere.
KISA President Sanzhar Kerimbek of the Department of Chemical and Biomolecular Engineering said, “We are so glad to show the diversity of KAIST and its rich culture. This is a big opportunity to get together with neighboring universities, CNU and UST and say thank you for their participation and support." Valentin Porcellini, an exchange students from France in the School of Computing, said, “We are so excited to have people taste our crepes, ratatouille, and other dishes.”
Associate Vice President of the International Office Jay Hyung Lee also said he was glad to see so many people joining this festival. While congratulating the students on the success of the festival, he said the festival will serve as an opportunity to better understand each other by sharing the food and culture.
(Photo caption: Paricipants stop by the Indonesian booth to purchase the food at the International Food Festival on May 26.)
2017.05.29 View 5132 -
Gout Diagnostic Strip Using a Single Teardrop
A novel diagnostic strip for gout patients using a single teardrop has been announced by KAIST research team. This technology analyzes biological molecules in tears for a non-invasive diagnosis, significantly reducing the time and expense previously required for a diagnosis.
The research team under Professor Ki-Hun Jeong of the Department of Bio and Brain Engineering succeeded in developing an affordable and elaborate gout diagnostic strip by depositing metal nanoparticles on paper. This technology can not only be used in diagnostic medicine and drug testing, but also in various other areas such as field diagnoses that require prompt and accurate detection of a certain substance.
Gout induces pain in joints due to needle-shaped uric acid crystal build up. In general, therapeutic treatments exist to administer pain relief, stimulate uric acid discharge, and uric acid depressant. Such treatments work for temporary relief, but there have significant limitations. Thus, patients are required to regularly check uric acid concentrations, as well as control their diets. Therefore, simpler ways to measure uric acid would greatly benefit gout control and its prevention in a more affordable and convenient manner.
Existing gout diagnostic techniques include measuring uric acid concentrations from blood samples or observing uric acid crystals from joint synovial fluid under a microscope. These existing methods are invasive and time consuming. To overcome their limitations, the research team uniformly deposited gold nanoislands with nanoplasnomics properties on the surface of paper that can easily collect tears.
Nanoplasnomics techniques collect light on the surface of a metal nanostructure, and can be applied to disease and health diagnostic indicators as well as for genetic material detection. Further, metals such as gold absorb stronger light when it is irradiated, and thus can maximize light concentration on board surfaces while maintaining the properties of paper. The developed metal nanostructure production technology allows the flexible manufacturing of nanostructures on a large surface, which in turn allows flexible control of light concentrations.
The research team grafted surface-enhanced Raman spectroscopy on paper diagnostic strips to allow uric acid concentration measurements in teardrops without additional indicators. The measured concentration in teardrops can be compared to blood uric acid concentrations for diagnosing gout.
Professor Jeong explained, “Based on these research results, our strip will make it possible to conduct low-cost, no indicator, supersensitive biological molecule analysis and fast field diagnosis using tears.” He continued, “Tears, as well as various other bodily fluids, can be used to contribute to disease diagnosis and physiological functional research.”
Ph.D. candidate Moonseong Park participated in the research as the first author of the paper that was published in the online edition of ACS Nano on December 14, 2016. Park said, “The strip will allow fast and simple field diagnosis, and can be produced on a large scale using the existing semiconductor process.”
(Figure 1. Optical image of paper gout diagnostic strip covered with gold)
(Figure 2. Scanning delectron microscopic image of paper gout diagnostic strip)
(Figure 3. Scanning electron microscope image of cellulos fiber coated with gold nanoislands)
(Figure 4. Gout diagnosis using tears)
2017.04.27 View 8113 -
Highly-Efficient Photoelectrochemical CO2 Reduction
Direct CO2 conversion has continuously attracted a great deal of attention as a technology to produce fuels and chemical building blocks from renewable energy resources. Specifically, substances such as carbon feedstocks and fuels can be produced by utilizing sunlight, water, and CO2 as semiconductors and a water interface through photoelectrochemical CO2 reduction.
A KAIST research team demonstrated a novel photoelectrode structure for highly-selective and efficient photoelectrochemical CO2 reduction reactions. The research team led by Professor Jihun Oh of the Graduate School of EEWS (Energy, Environment, Water and Sustainability) presented a Si photoelectrode with a nanoporous Au thin film that is capable of reducing CO2 to CO with 90 percent selectivity in aqueous solution. The research team’s technology will provide a basic framework for designing the semiconductor photoelectrode structure necessary for photoelectrochemical conversion.
In order to achieve steady conversion of CO2, it is necessary to use a high-performance catalyst to lower overpotential. Among the metal catalysts, Au is known to be an electrocatalyst that converts CO2 to CO.
Conventionally, bare Au, as a catalyst, produces a lot of hydrogen gas due to its low CO selectivity. In addition, the high cost of Au remains a challenge in using the catalyst. Professor Oh’s research team addressed the issue by creating a nanoporous Au thin film formed by the electrochemical reduction of an anodized Au thin film.
As a result, the team could demonstrate an efficient, selective photoelectrochemical reduction reaction of CO2 to CO using electrochemically-treated Au thin films on a Si photoelectrode. The electrochemical reduction on anodized Au thin films forms a nanoporous thin layer exhibiting many grain boundaries of nanoparticles on the Au surface. This dramatically improves the selectivity of the reduction reaction with a maximum CO faradaic efficiency of over 90% at low overpotential and durability.
The research team also used an Au thin film of about 200 nanometers, 50,000 times thinner than previously reported nanostructured Au catalysts, resulting in a cost-effective catalyst. When depositing the catalyst on the semiconductor surface in the type of nanoparticles, the substrate of the thin film will be affected in the course of electrochemical reduction.
Thus, the research team designed a new Si photoelectrode with mesh-type co-catalysts that are independently wired at the front and back of the photoelectrode without influencing the photoelectrode, and made it possible for electrochemical reduction.
Due to the superior CO2 reduction reaction activity of the nanoporous Au mesh and high photovoltage from Si, the Si photoelectrode with the nanoporous Au thin film mesh shows conversion of CO2 to CO with 91% Faradaic efficiency at positive potential than CO equilibrium potential.
Professor Oh explained, “This technology will serve as a platform for diverse semiconductors and catalysts. Researchers can further improve the solar-to-CO2 conversion efficiency using this technology.
Dr. Jun Tae Song, the first author continued, “This new approach made it possible to develop a simple but very important type of electrode structure. It is the first time to achieve CO2 conversion at the potential lower than equilibrium potential. We believe that our research will contribute to efficient CO2 conversion.”
This research was published in the inside front cover of Advanced Energy Materials on February 8, 2017. The research was funded and supported by the Korea Carbon Capture & Sequestration R&D Center. Professor Sung-Yoon Chung of the EEWS also participated in this research.
(Figure: Schematic diagram of a Si photoelectrode that patterns with mesh-type nanoporous Au)
2017.03.08 View 9091 -
Adsorbent That Can Selectively Remove Water Contaminants
Professor Cafer T. Yavuz and his team at the Graduate School of Energy, Environment, Water, and Sustainability (EEWS) have developed an adsorbent that can selectively capture soluble organic contaminants in water.
This water treatment adsorbent is a fluorine-based nanoporous polymer that can selectively remove water-soluble micromolecules. It has the added advantage of being cheap and easily synthesized, while also being renewable.
The results of this research have been published online in Nature Communication on November 10, 2016. The research paper is titled “Charge-specific Size-dependent Separation of Water-soluble Organic Molecules by Fluorinated Nanoporous Networks.” (DOI: 10.1038/ncomms13377)
Water pollution is accelerating as a result of global industrial development and warming. As new materials are produced and applied in the agricultural and industrial sectors, the types of contaminants expelled as sewage and waste water are also becoming diverse.
Chemicals such as dyes and pesticides can be especially harmful because they are made up of small and highly soluble organic particles that cannot be completely removed during the water treatment process, ultimately ending up in our drinking water.
The current conventional water treatment systems utilize processes such as activated carbon, ozonolysis, and reverse osmosis membrane. These processes, however, are designed to remove larger organic molecules with lower solubility, thus removal of very small molecules with high solubility is difficult. In addition, these micromolecules tend to be charged, therefore are less easily separated in aqueous form.
The research team aimed to remove these small molecules using a new adsorbent technology.
In order to remove aqueous organic molecular contaminants, the team needed an adsorbent that can adsorb micro-sized molecules. It also needed to introduce a chemical function that would allow it to selectively adsorb molecules, and lastly, the adsorbent needed to be structurally stable as it would be used underwater.
The team subsequently developed an adsorbent of fluorine-based porous organic polymer that met all the conditions listed above. By controlling the size of the pores, this adsorbent is able to selectively adsorb aqueous micromolecules of less than 1-2 nm in size.
In addition, in order to separate specific contaminants, there should be a chemical functionality, such as the ability to strongly interact with the target material. Fluorine, the most electronegative atom, interacts strongly with charged soluble organic molecules.
The research team incorporated fluorine into an adsorbent, enabling it to separate charged organic molecules up to 8 times faster than neutral molecules.
The adsorbent developed by Professor Yavuz’s team has wide industrial applications. It can be used in batch-adsorption tests, as well as in column separation for size- and charge-specific adsorption.
Professor Yavuz stated that “the charge-selective properties displayed by fluorine has the potential to be applied in desalination or water treatment processes using membranes."
This paper was first-authored by Dr. Jeehye Byun, and the research was funded by KAIST’s High Risk High Return Program and the Ministry of Science, ICT and Future Planning of Korea’s Mid-Career Researcher Program, as well as its Technology Development Program to Solve Climate Change.
Figure 1. Diagram conceptualizing the process of charge- and size-specific separation by the fluorine-based porous polymer adsorbent
Figure 2. Difference in absorbance before and after using a porous fluorine polymer column to separate organic molecules
Figure 3. Adsorption properties of a fluorine polymer according to the charge and size of organic molecules
2017.01.17 View 9362 -
KAIST Alumni of the Year
(From left Chul-Hwan Kim, president and CEO of Orange Power, Hooshik Kim, president & CEO of Vieworks, Chilhee Chung, presient of Samsung Advanced Institute of Technology, KAIST President Sung-Mo Kang, KAIST Alumni Association President Jung-Sik Ko, Won-Pil Baek, senior vice president for R&D program at Korea Atomic Energy Research Insitute, Hyonho Jung, CEO of Medytox, Jaehwa Kim on behalf of Han-Oh Park, president & CEO of Bioneer Corporation)
The KAIST Alumni Association presented the Alumni of the Year award to six of its most accomplished alumni at the New Year dinner held at the Lotte Hotel in Seoul on January 14.
KAIST alumni community, which numbers over 500,000, has made a significant impact around the globe in science and technology, industry, education, and the public sector. Each year, the KAIST Alumni Association honors individuals who have made a significant contribution with outstanding leadership through the Alumni of the Year awards.
KAIST Alumni Association President Jung-Sik Ko awarded the recipients at the dinner. About 200 alumni, faculty, and students, including KAIST President Sung-Mo Kang, joined the celebration.
The 2016 awardees are Dr. Chilhee Chung, president of Samsung Advanced Institute of Technology(SAIT); Dr.Won-Pil Baek, senior vice president for R&D program at Korea Atomic Energy Research Institute(KAERI); Dr.Han-Oh Park, president & CEO of Bioneer Corporation; Dr.Hyonho Jung, CEO of Medytox; Hooshik Kim, president & CEO of Vieworks; and Dr.Chul-Hwan Kim, president & CEO of Orange Power.
Dr. Chung of SAIT (MS in physics ’79) played a leading role in developing top-notch system semiconductors and memory device technology while serving as president of the Samsung Electronic Semiconductor R&D Center. He has focused on the development of cutting-edge future technology, the Quantum Dot, by incorporating eco-friendly materials with the highest efficiency and color purity which is cadmium-free.
Working at KAERI since 2001, Dr. Baek (Ph.D. in nuclear and quantum engineering ’87) has made contributions to help Korea emerge as a nuclear technology powerhouse. He played a critical role in developing and facilitating a global nuclear safety verification facility dubbed ‘ATLAS.’ Such nuclear technological prowess led the Korean government to advance into the foreign markets, such as exporting nuclear power plants to United Arab Emirates.
The CEO of Bioneer, Dr. Park (Ph.D. in chemistry ’87) started a bio-venture in Korea. His company has developed hundreds of reagents, diagnostic kits, and advanced equipment for gene research over two decades. Bioneer has paved the way for establishing a world-class level of infrastructure in genomic technology. By developing the innovative technology "SAMiRNA ™ (Self-Assembled-Micelle-inhibitory-RNA)" that overcomes the problems in drug development, Bioneer presented a new solution for the treatment of incurable diseases. In collaboration with global pharmaceutical companies and research groups, Dr. Park has successfully led joint development in the licensing of new therapeutic medicine candidates for various incurable diseases.
Dr. Jung (Ph.D. in biological sciences ’88) founded the bio-pharmaceutical company Medytox in 2000. Medytox is the first company in Korea that commercialized botulinum toxin formulation. Medytox developed the non-animal liquid botulinum toxin formulation for the first time in the world. It successfully localized botulinum preparation that can treat various neurological diseases. Medytox’s new toxin formulation resulted in improving public health care as well as relieving the heavy dependence on importing bio-pharmaceutical products.
As the CEO of Vieworks, Kim (MS in physics ’95) succeeded in commercializing of digital X-ray. Especially, it is leading the design of optical and image systems that affect the quality of digital X-ray image. Kim’s company established related technology base, contributing to human health promotion and national industrial development.
President Kim of Orange Power (Ph.D. in chemical and biomolecular engineering ’93) is also the founder of the KITE Entrepreneurship Foundation. He launched Biogenix Co., Ltd. and Image and Materials Co. in 2005. In order to nurture an entrepreneurship and start-ups eco-system, he invested 10 billion KRW from the proceeds of the sale of one of his start-ups. In addition, he started Orange Power Co., Ltd. in 2012 to solve the secondary battery heat problem and established a global partnership with Hydro Quebec in Canada, Nexion in UK, Volkswagen of Germany, and Tesla of the US.
2017.01.16 View 10717 -
Direct Utilization of Elemental Sulfur for Microporous Polymer Synthesis
Using elemental sulfur as an alternative chemical feedstock, KAIST researchers have produced novel microporous polymers to sift CO2 from methane in natural-gas processing.
Methane, a primary component of natural gas, has emerged recently as an important energy source, largely owing to its abundance and relatively clean nature compared with other fossil fuels. In order to use natural gas as a fuel, however, it must undergo a procedure called “hydrodesulfurization” or “natural gas sweetening” to reduce sulfur-dioxide emissions from combustion of fossil fuels. This process leads to excessive and involuntary production of elemental sulfur. Although sulfur is one of the world’s most versatile and common elements, it has relatively few large-scale applications, mostly for gunpowder and sulfuric acid production.
Thus, the development of synthetic and processing methods to convert sulfur into useful chemicals remains a challenge. A research team led by Professor Ali Coskun from the Graduate School of EEWS (Energy, Environment, Water and Sustainability) at Korea Advanced Institute of Science and Technology (KAIST) has recently introduced a new approach to resolving this problem by employing elemental sulfur directly in the synthesis of microporous polymers for the process of natural-gas sweetening.
Natural gas, containing varying amounts of carbon dioxide (CO2) and hydrogen sulfide (H2S), is generally treated with amine solutions, followed by the regeneration of these solutions at increased temperatures to release captured CO2 and H2S. A two-step separation is involved in removing these gases. The amine solutions first remove H2S, and then CO2 is separated from methane (CH4) with either amine solutions or porous sorbents such as microporous polymers.
Using elemental sulfur and organic linkers, the research team developed a solvent and catalyst-free strategy for the synthesis of ultramicroporous benzothiazole polymers (BTAPs) in quantitative yields. BTAPs were found to be highly porous and showed exceptional physiochemical stability. In-situ chemical impregnation of sulfur within the micropores increased CO2 affinity of the sorbent, while limiting diffusion of CH4. BTAPs, as low-cost, scalable solid-sorbents, showed outstanding CO2 separation ability for flue gas, as well as for natural and landfill gas conditions.
The team noted that: “Each year, millions of tons of elemental sulfur are generated as a by-product of petroleum refining and natural-gas processing, but industries and businesses lacked good ideas for using it. Our research provides a solution: the direct utilization of elemental sulfur into the synthesis of ultramicroporous polymers that can be recycled back into an efficient and sustainable process for CO2 separation. Our novel polymeric materials offer new possibilities for the application of a little-used natural resource, sulfur, to provide a sustainable solution to challenging environmental issues.”
This work was published online in Chem on September 8, 2016 and also highlighted in C&EN (Chemical & Engineering News) by the American Chemical Society (ACS) on September 19, 2016. The research paper was entitled “Direct Utilization of Elemental Sulfur in the Synthesis of Microporous Polymers for Natural Gas Sweetening.” (DOI: 10.1016/j.chempr.2016.08.003)
Figure 1. A Schematic Image of Direct Utilization of Elemental Sulfur
This image shows direct utilization of elemental sulfur in the synthesis of microporous polymers and its gas separation performance.
Figure 2. BTAP’s Breakthrough Experiment under Pre-mixed Gas Conditions
This data presents the breakthrough measurements for CO2-containing binary gas-mixture streams with different feed-gas compositions to investigate the CO2 capture capacity of ultramicroporous benzothiazole polymers (BTAPs) for large-scale applications under simulated conditions of natural and landfill gases.
2016.10.05 View 8341 -
KAIST Offers Online Science Magnet High School Program
The Global Institute for Talented Education at KAIST has begun providing middle and high school students with in-depth online science education.
The institute receives applications until March 20, 2016. For details, please refer to the website: http://talented.kaist.ac.kr.
The program will run from March 21, 2016 to June 13, 2016.
Any middle and high school student can take courses on mathematics, science (physics, chemistry and biology), and information system (C language and Python computer language) based on their levels and needs. A total of 23 courses will be offered at the level of the first year of middle school to the second year of high school.
The online lecturers are drawn from science-magnet high schools nationwide. They will lead the classes to become more interactive with students, encouraging discussions and questions and answers.
KAIST students will also take part as tutors, helping the middle and high school students better understand the basic concept of the subjects they undertake and and to think creatively to solve problems.
About 500 top students will be chosen from the online course applicants to participate in a science camp hosted by KAIST during summer and winter vacations.
2016.03.14 View 4713 -
A New Way to Look at MOFs
An international research team composed of researchers from KAIST (led by Professors Osamu Terasaki and Jeung Ku Kang at the Graduate School of Energy, Environment, Water and Sustainability) and other universities, including UC Berkeley, has recently published research results on the adsorption process of metal-organic frameworks (MOFs) in Nature (November 9, 2015).
MOFs are porous three-dimensional crystals with a high internal surface area, which have a wide range of applications involving adsorption such as hydrogen, methane, or carbon dioxide storage. In the paper entitled “Extra Adsorption and Adsorbate Superlattice Formation in Metal-organic Frameworks,” the research team described their observation of a very specific interpore interaction process in MOFs.
For additional information, please see:
A New Way to Look at MOFs
International study challenges prevailing view on how metal organic frameworks store gases
EurekAlert, November 9, 2015
http://www.eurekalert.org/pub_releases/2015-11/dbnl-anw110915.php
(Courtesy of the US Department of Energy and Lawrence Berkeley National Laboratory news release)
2015.11.13 View 7771 -
KAIST Invites the World's Top Accelerators to the "Start-up Accelerator Forum"
The Institute for Start-up KAIST hosted a forum on start-up accelerators in cooperation with the KAIST Pangyo Center. More than 100 experts participated in the start-up forum including experts from the world’s top accelerators from Europe and the United States.
Start-up accelerators are companies or institutions that provide support to start-up companies in the early stages to grow into sustainable ventures. Their roles include providing networking opportunities to mentors in technology, marketing, design, business strategy, and potential investors by hosting Demo Days.
The KAIST Start-up Forum is an annual event organized by the Institute for Start-up KAIST to encourage conversations between universities and corporations to promote start-up companies and innovative business strategies.
The forum’s organizers invited Professor Olli Vuola of Aalto University in Finland; Milton B. McColl, the CEO of Gauss Surgical; Kara Shurmanitine, the Director of the Division of Global Partnership at Mass Challenge; and Jimmy Kim, the co-founder of SparkLabs Global Ventures.
2015.10.29 View 3301 -
Brain Cognitive Engineering Experts from Korea and Abroad Gather at KAIST
The symposium presents recent and future research trends in brain and cognitive engineering.
KAIST hosted the Brain Cognitive Engineering Symposium on September 24, 2015, at the Dream Hall of the Chung Moon Soul building on campus. Around 100 experts in the field of neuroscience participated.
Organized by the Department of Bio and Brain Engineering at KAIST, the symposium celebrated the establishment of the Brain Cognitive Engineering Program at the university and examined the recent research trends in neuroscience.
Six neuroscience experts presented their research and held discussions.
Professor Paul M. Thompson of the University of Southern California (USC), a renowned scientist in neurology imaging genetics, gave a speech entitled “The ENIGMA Project: Mapping Disease and Genetic Effects on the Human Brain in 30,000 People Worldwide.”
Professor Jae-seung Jeong of KAIST’s Department of Bio and Brain Engineering, Director Sung-Gi Kim of IBS Center for Neuroscience Imaging Research, Professor Sung-Hwan Lee of Korea University’s Department of Brain Engineering, Professor Cheil-Moon of DGIST’s Department of Brain and Cognitive Science, and Professor Jun-Tani of KAIST’s Department of Electrical Engineering also participated in the symposium.
Participants discussed the most recent findings in the field of brain science such as the education and research trends of brain cognitive engineering, trends of the world’s brain integrated science, the prospects of brain cognitive engineering program, brain activities that induce blood flow and fMRI, activity production in the brain cortex model as well as the development of functional hierarchy for the motor visual perception, and the neurorobotics research.
Professor Jeong said that “this symposium is a place for examination of the most recent research findings in the field of neuroscience as well as for discussion of its education,”and that “it would be an important opportunity for learning research on brain’s basic mechanisms as well as its applications.”
2015.09.25 View 7680