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KAIST Professor Jiyun Lee becomes the first Korean to receive the Thurlow Award from the American Institute of Navigation
< Distinguished Professor Jiyun Lee from the KAIST Department of Aerospace Engineering >
KAIST (President Kwang-Hyung Lee) announced on January 27th that Distinguished Professor Jiyun Lee from the KAIST Department of Aerospace Engineering had won the Colonel Thomas L. Thurlow Award from the American Institute of Navigation (ION) for her achievements in the field of satellite navigation.
The American Institute of Navigation (ION) announced Distinguished Professor Lee as the winner of the Thurlow Award at its annual awards ceremony held in conjunction with its international conference in Long Beach, California on January 25th. This is the first time a person of Korean descent has received the award.
The Thurlow Award was established in 1945 to honor Colonel Thomas L. Thurlow, who made significant contributions to the development of navigation equipment and the training of navigators. This award aims to recognize an individual who has made an outstanding contribution to the development of navigation and it is awarded to one person each year. Past recipients include MIT professor Charles Stark Draper, who is well-known as the father of inertial navigation and who developed the guidance computer for the Apollo moon landing project.
Distinguished Professor Jiyun Lee was recognized for her significant contributions to technological advancements that ensure the safety of satellite-based navigation systems for aviation. In particular, she was recognized as a world authority in the field of navigation integrity architecture design, which is essential for ensuring the stability of intelligent transportation systems and autonomous unmanned systems. Distinguished Professor Lee made a groundbreaking contribution to help ensure the safety of satellite-based navigation systems from ionospheric disturbances, including those affected by sudden changes in external factors such as the solar and space environment.
She has achieved numerous scientific discoveries in the field of ionospheric research, while developing new ionospheric threat modeling methods, ionospheric anomaly monitoring and mitigation techniques, and integrity and availability assessment techniques for next-generation augmented navigation systems. She also contributed to the international standardization of technology through the International Civil Aviation Organization (ICAO).
Distinguished Professor Lee and her research group have pioneered innovative navigation technologies for the safe and autonomous operation of unmanned aerial vehicles (UAVs) and urban air mobility (UAM). She was the first to propose and develop a low-cost navigation satellite system (GNSS) augmented architecture for UAVs with a near-field network operation concept that ensures high integrity, and a networked ground station-based augmented navigation system for UAM. She also contributed to integrity design techniques, including failure monitoring and integrity risk assessment for multi-sensor integrated navigation systems.
< Professor Jiyoon Lee upon receiving the Thurlow Award >
Bradford Parkinson, professor emeritus at Stanford University and winner of the 1986 Thurlow Award, who is known as the father of GPS, congratulated Distinguished Professor Lee upon hearing that she was receiving the Thurlow Award and commented that her innovative research has addressed many important topics in the field of navigation and her solutions are highly innovative and highly regarded.
Distinguished Professor Lee said, “I am very honored and delighted to receive this award with its deep history and tradition in the field of navigation.” She added, “I will strive to help develop the future mobility industry by securing safe and sustainable navigation technology.”
2024.01.26 View 3440 -
A KAIST Research Team Observes the Processes of Memory and Cognition in Real Time
The human brain contains approximately 86 billion neurons and 600 trillion synapses that exchange signals between the neurons to help us control the various functions of the brain including cognition, emotion, and memory. Interestingly, the number of synapses decrease with age or as a result of diseases like Alzheimer’s, and research on synapses thus attracts a lot of attention. However, limitations have existed in observing the dynamics of synapse structures in real time.
On January 9, a joint research team led by Professor Won Do Heo from the KAIST Department of Biological Sciences, Professor Hyung-Bae Kwon from Johns Hopkins School of Medicine, and Professor Sangkyu Lee from the Institute for Basic Science (IBS) revealed that they have developed the world’s first technique to allow a real-time observation of synapse formation, extinction, and alterations.
Professor Heo’s team conjugated dimerization-dependent fluorescent proteins (ddFP) to synapses in order to observe the process in which synapses create connections between neurons in real time. The team named this technique SynapShot, by combining the words ‘synapse’ and snapshot’, and successfully tracked and observed the live formation and extinction processes of synapses as well as their dynamic changes.
< Figure 1. To observe dynamically changing synapses, dimerization-dependent fluorescent protein (ddFP) was expressed to observe flourescent signals upon synapse formation as ddFP enables fluorescence detection through reversible binding to pre- and postsynaptic terminals. >
Through a joint research project, the teams led by Professor Heo and Professor Sangkyu Lee at IBS together designed a SynapShot with green and red fluorescence, and were able to easily distinguish the synapse connecting two different neurons. Additionally, by combining an optogenetic technique that can control the function of a molecule using light, the team was able to observe the changes in the synapses while simultaneously inducing certain functions of the neurons using light.
Through more joint research with the team led by Professor Hyung-Bae Kwon at the Johns Hopkins School of Medicine, Professor Heo’s team induced several situations on live mice, including visual discrimination training, exercise, and anaesthesia, and used SynapShot to observe the changes in the synapses during each situation in real time. The observations revealed that each synapse could change fairly quickly and dynamically. This was the first-ever case in which the changes in synapses were observed in a live mammal.
< Figure 2. Microscopic photos observed through changes of the flourescence of the synapse sensor (SynapShot) by cultivating the neurons of an experimental rat and expressing the SynapShot. The changes in the synapse that is created when the pre- and post-synaptic terminals come into contact and the synapse that disappears after a certain period of time are measured by the fluorescence of the SynapShot. >
Professor Heo said, “Our group developed SynapShot through a collaboration with domestic and international research teams, and have opened up the possibility for first-hand live observations of the quick and dynamic changes of synapses, which was previously difficult to do. We expect this technique to revolutionize research methodology in the neurological field, and play an important role in brightening the future of brain science.”
This research, conducted by co-first authors Seungkyu Son (Ph.D. candidate), Jinsu Lee (Ph.D. candidate) and Dr. Kanghoon Jung from Johns Hopkins, was published in the online edition of Nature Methods on January 8 under the title “Real-time visualization of structural dynamics of synapses in live cells in vivo”, and will be printed in the February volume.
< Figure 3. Simultaneous use of green-SynapShot and red-SynapShot to distinguish and observe synapses with one post-terminal and different pre-terminals. >
< Figure 4. Dimer-dependent fluorescent protein (ddFP) exists as a green fluorescent protein as well as a red fluorescent protein, and can be applied together with blue light-activated optogenetic technology. After activating Tropomyosin receptor kinase B (TrkB) by blue light using optogenetic technology, the strengthening of synaptic connections through signals of brain-derived neurotrophic factor is observed using red-SynapShot. >
< Figure 5. Micrographs showing real-time changing synapses in the visual cortex of mice trained through visual training using in vivo imaging techniques such as two-photon microscopy as well as at the cellular level. >
This research was supported by Mid-Sized Research Funds and the Singularity Project from KAIST, and by IBS.
2024.01.18 View 3661 -
KAIST Research team develops anti-icing film that only requires sunlight
A KAIST research team has developed an anti-icing and de-icing film coating technology that can apply the photothermal effect of gold nanoparticles to industrial sites without the need for heating wires, periodic spray or oil coating of anti-freeze substances, and substrate design alterations.
The group led by Professor Hyoungsoo Kim from the Department of Mechanical Engineering (Fluid & Interface Laboratory) and Professor Dong Ki Yoon from the Department of Chemistry (Soft Material Assembly Group) revealed on January 3 to have together developed an original technique that can uniformly pattern gold nanorod (GNR) particles in quadrants through simple evaporation, and have used this to develop an anti-icing and de-icing surface.
Many scientists in recent years have tried to control substrate surfaces through various coating techniques, and those involving the patterning of functional nanomaterials have gained special attention. In particular, GNR is considered a promising candidate nanomaterial for its biocompatibility, chemical stability, relatively simple synthesis, and its stable and unique property of surface plasmon resonance. To maximize the performance of GNR, it is important to achieve a high uniformity during film deposition, and a high level of rod alignment. However, achieving both criteria has thus far been a difficult challenge.
< Figure 1. Conceptual image to display Hydrodynamic mechanisms for the formation of a homogeneous quadrant cellulose nanocrystal(CNC) matrix. >
To solve this, the joint research team utilized cellulose nanocrystal (CNC), a next-generation functional nanomaterial that can easily be extracted from nature. By co-assembling GNR on CNC quadrant templates, the team could uniformly dry the film and successfully obtain a GNR film with a uniform alignment in a ring-shape. Compared to existing coffee-ring films, the highly uniform and aligned GNR film developed through this research showed enhanced plasmonic photothermal properties, and the team showed that it could carry out anti-icing and de-icing functions by simply irradiating light in the visible wavelength range.
< Figure 2. Optical and thermal performance evaluation results of gold nanorod film and demonstration of plasmonic heater for anti-icing and de-icing. >
Professor Hyoungsoo Kim said, “This technique can be applied to plastic, as well as flexible surfaces. By using it on exterior materials and films, it can generate its own heat energy, which would greatly save energy through voluntary thermal energy harvesting across various applications including cars, aircrafts, and windows in residential or commercial spaces, where frosting becomes a serious issue in the winter.” Professor Dong Ki Yoon added, “This research is significant in that we can now freely pattern the CNC-GNR composite, which was previously difficult to create into films, over a large area. We can utilize this as an anti-icing material, and if we were to take advantage of the plasmonic properties of gold, we can also use it like stained-glass to decorate glass surfaces.”
This research was conducted by Ph.D. candidate Jeongsu Pyeon from the Department of Mechanical Engineering, and his co-first author Dr. Soon Mo Park (a KAIST graduate, currently a post-doctoral associate at Cornell University), and was pushed in the online volume of Nature Communication on December 8, 2023 under the title “Plasmonic Metasurfaces of Cellulose Nanocrystal Matrices with Quadrants of Aligned Gold Nanorods for Photothermal Anti-Icing." Recognized for its achievement, the research was also selected as an editor’s highlight for the journals Materials Science and Chemistry, and Inorganic and Physical Chemistry.
This research was supported by the Individual Basic Mid-Sized Research Fund from the National Research Foundation of Korea and the Center for Multiscale Chiral Architectures.
2024.01.16 View 6315 -
KAIST Demonstrates AI and sustainable technologies at CES 2024
On January 2, KAIST announced it will be participating in the Consumer Electronics Show (CES) 2024, held between January 9 and 12.
CES 2024 is one of the world’s largest tech conferences to take place in Las Vegas. Under the slogan “KAIST, the Global Value Creator” for its exhibition, KAIST has submitted technologies falling under one of following themes: “Expansion of Human Intelligence, Mobility, and Reality”, and “Pursuit of Human Security and Sustainable Development”.
24 startups and pre-startups whose technologies stand out in various fields including artificial intelligence (AI), mobility, virtual reality, healthcare and human security, and sustainable development, will welcome their visitors at an exclusive booth of 232 m2 prepared for KAIST at Eureka Park in Las Vegas.
12 businesses will participate in the first category, “Expansion of Human Intelligence, Mobility, and Reality”, including MicroPix, Panmnesia, DeepAuto, MGL, Reports, Narnia Labs, EL FACTORY, Korea Position Technology, AudAi, Planby Technologies, Movin, and Studio Lab.
In the “Pursuit of Human Security and Sustainable Development” category, 12 businesses including Aldaver, ADNC, Solve, Iris, Blue Device, Barreleye, TR, A2US, Greeners, Iron Boys, Shard Partners and Kingbot, will be introduced.
In particular, Aldaver is a startup that received the Korean Business Award 2023 as well as the presidential award at the Challenge K-Startup with its biomimetic material and printing technology. It has attracted 4.5 billion KRW of investment thus far.
Narnia Labs, with its AI design solution for manufacturing, won the grand prize for K-tech Startups 2022, and has so far attracted 3.5 billion KRW of investments.
Panmnesia is a startup that won the 2024 CES Innovation Award, recognized for their fab-less AI semiconductor technology. They attracted 16 billion KRW of investment through seed round alone.
Meanwhile, student startups will also be presented during the exhibition. Studio Lab received a CES 2024 Best of Innovation Award in the AI category. The team developed the software Seller Canvas, which automatically generates a page for product details when a user uploads an image of a product.
The central stage at the KAIST exhibition booth will be used to interview members of the participating startups between Jan 9 to 11, as well as a networking site for businesses and invited investors during KAIST NIGHT on the evening of 10th, between 5 and 7 PM.
Director Sung-Yool Choi of the KAIST Institute of Technology Value Creation said, “Through CES 2024, KAIST will overcome the limits of human intelligence, mobility, and space with the deep-tech based technologies developed by its startups, and will demonstrate its achievements for realizing its vision as a global value-creating university through the solutions for human security and sustainable development.”
2024.01.05 View 5193 -
KAIST presents strategies for environmentally friendly and sustainable polyamides production
- Provides current research trends in bio-based polyamide production
- Research on bio-based polyamides production gains importance for achieving a carbon-neutral society
Global industries focused on carbon neutrality, under the slogan "Net-Zero," are gaining increasing attention. In particular, research on microbial production of polymers, replacing traditional chemical methods with biological approaches, is actively progressing.
Polyamides, represented by nylon, are linear polymers widely used in various industries such as automotive, electronics, textiles, and medical fields. They possess beneficial properties such as high tensile strength, electrical insulation, heat resistance, wear resistance, and biocompatibility. Since the commercialization of nylon in 1938, approximately 7 million tons of polyamides are produced worldwide annually. Considering their broad applications and significance, producing polyamides through bio-based methods holds considerable environmental and industrial importance.
KAIST (President Kwang-Hyung Lee) announced that a research team led by Distinguished Professor Sang Yup Lee, including Dr. Jong An Lee and doctoral candidate Ji Yeon Kim from the Department of Chemical and Biomolecular Engineering, published a paper titled "Current Advancements in Bio-Based Production of Polyamides”. The paper was featured on the cover of the monthly issue of "Trends in Chemistry” by Cell Press.
As part of climate change response technologies, bio-refineries involve using biotechnological and chemical methods to produce industrially important chemicals and biofuels from renewable biomass without relying on fossil resources. Notably, systems metabolic engineering, pioneered by KAIST's Distinguished Professor Sang Yup Lee, is a research field that effectively manipulates microbial metabolic pathways to produce valuable chemicals, forming the core technology for bio-refineries. The research team has successfully developed high-performance strains producing a variety of compounds, including succinic acid, biodegradable plastics, biofuels, and natural products, using systems metabolic engineering tools and strategies.
The research team predicted that if bio-based polyamide production technology, which is widely used in the production of clothing and textiles, becomes widespread, it will attract attention as a future technology that can respond to the climate crisis due to its environment-friendly production technology. In this study, the research team comprehensively reviewed the bio-based polyamide production strategies. They provided insights into the advancements in polyamide monomer production using metabolically engineered microorganisms and highlighted the recent trends in bio-based polyamide advancements utilizing these monomers. Additionally, they reviewed the strategies for synthesizing bio-based polyamides through chemical conversion of natural oils and discussed the biodegradability and recycling of the polyamides. Furthermore, the paper presented the future direction in which metabolic engineering can be applied for the bio-based polyamide production, contributing to environmentally friendly and sustainable society.
Ji Yeon Kim, the co-first author of this paper from KAIST, stated "The importance of utilizing systems metabolic engineering tools and strategies for bio-based polyamides production is becoming increasingly prominent in achieving carbon neutrality."
Professor Sang Yup Lee emphasized, "Amid growing concerns about climate change, the significance of environmentally friendly and sustainable industrial development is greater than ever. Systems metabolic engineering is expected to have a significant impact not only on the chemical industry but also in various fields."
< [Figure 1] A schematic overview of the overall process for polyamides production >
This paper by Dr. Jong An Lee, PhD student Ji Yeon Kim, Dr. Jung Ho Ahn, and Master Yeah-Ji Ahn from the Department of Chemical and Biomolecular Engineering at KAIST was published in the December issue of 'Trends in Chemistry', an authoritative review journal in the field of chemistry published by Cell. It was published on December 7 as the cover paper and featured review.
※ Paper title: Current advancements in the bio-based production of polyamides
※ Author information: Jong An Lee, Ji Yeon Kim, Jung Ho Ahn, Yeah-Ji Ahn, and Sang Yup Lee
This research was conducted with the support from the development of platform technologies of microbial cell factories for the next-generation biorefineries project and C1 gas refinery program by Korean Ministry of Science and ICT.
< [Figure 2] Cover paper of the December issue of Trends in Chemistry >
2023.12.21 View 3774 -
North Korea and Beyond: AI-Powered Satellite Analysis Reveals the Unseen Economic Landscape of Underdeveloped Nations
- A joint research team in computer science, economics, and geography has developed an artificial intelligence (AI) technology to measure grid-level economic development within six-square-kilometer regions.
- This AI technology is applicable in regions with limited statistical data (e.g., North Korea), supporting international efforts to propose policies for economic growth and poverty reduction in underdeveloped countries.
- The research team plans to make this technology freely available for use to contribute to the United Nations' Sustainable Development Goals (SDGs).
The United Nations reports that more than 700 million people are in extreme poverty, earning less than two dollars a day. However, an accurate assessment of poverty remains a global challenge. For example, 53 countries have not conducted agricultural surveys in the past 15 years, and 17 countries have not published a population census. To fill this data gap, new technologies are being explored to estimate poverty using alternative sources such as street views, aerial photos, and satellite images.
The paper published in Nature Communications demonstrates how artificial intelligence (AI) can help analyze economic conditions from daytime satellite imagery. This new technology can even apply to the least developed countries - such as North Korea - that do not have reliable statistical data for typical machine learning training.
The researchers used Sentinel-2 satellite images from the European Space Agency (ESA) that are publicly available. They split these images into small six-square-kilometer grids. At this zoom level, visual information such as buildings, roads, and greenery can be used to quantify economic indicators. As a result, the team obtained the first ever fine-grained economic map of regions like North Korea. The same algorithm was applied to other underdeveloped countries in Asia: North Korea, Nepal, Laos, Myanmar, Bangladesh, and Cambodia (see Image 1).
The key feature of their research model is the "human-machine collaborative approach," which lets researchers combine human input with AI predictions for areas with scarce data. In this research, ten human experts compared satellite images and judged the economic conditions in the area, with the AI learning from this human data and giving economic scores to each image. The results showed that the Human-AI collaborative approach outperformed machine-only learning algorithms.
< Image 1. Nightlight satellite images of North Korea (Top-left: Background photo provided by NASA's Earth Observatory). South Korea appears brightly lit compared to North Korea, which is mostly dark except for Pyongyang. In contrast, the model developed by the research team uses daytime satellite imagery to predict more detailed economic predictions for North Korea (top-right) and five Asian countries (Bottom: Background photo from Google Earth). >
The research was led by an interdisciplinary team of computer scientists, economists, and a geographer from KAIST & IBS (Donghyun Ahn, Meeyoung Cha, Jihee Kim), Sogang University (Hyunjoo Yang), HKUST (Sangyoon Park), and NUS (Jeasurk Yang). Dr Charles Axelsson, Associate Editor at Nature Communications, handled this paper during the peer review process at the journal.
The research team found that the scores showed a strong correlation with traditional socio-economic metrics such as population density, employment, and number of businesses. This demonstrates the wide applicability and scalability of the approach, particularly in data-scarce countries. Furthermore, the model's strength lies in its ability to detect annual changes in economic conditions at a more detailed geospatial level without using any survey data (see Image 2).
< Image 2. Differences in satellite imagery and economic scores in North Korea between 2016 and 2019. Significant development was found in the Wonsan Kalma area (top), one of the tourist development zones, but no changes were observed in the Wiwon Industrial Development Zone (bottom). (Background photo: Sentinel-2 satellite imagery provided by the European Space Agency (ESA)). >
This model would be especially valuable for rapidly monitoring the progress of Sustainable Development Goals such as reducing poverty and promoting more equitable and sustainable growth on an international scale. The model can also be adapted to measure various social and environmental indicators. For example, it can be trained to identify regions with high vulnerability to climate change and disasters to provide timely guidance on disaster relief efforts.
As an example, the researchers explored how North Korea changed before and after the United Nations sanctions against the country. By applying the model to satellite images of North Korea both in 2016 and in 2019, the researchers discovered three key trends in the country's economic development between 2016 and 2019. First, economic growth in North Korea became more concentrated in Pyongyang and major cities, exacerbating the urban-rural divide. Second, satellite imagery revealed significant changes in areas designated for tourism and economic development, such as new building construction and other meaningful alterations. Third, traditional industrial and export development zones showed relatively minor changes.
Meeyoung Cha, a data scientist in the team explained, "This is an important interdisciplinary effort to address global challenges like poverty. We plan to apply our AI algorithm to other international issues, such as monitoring carbon emissions, disaster damage detection, and the impact of climate change."
An economist on the research team, Jihee Kim, commented that this approach would enable detailed examinations of economic conditions in the developing world at a low cost, reducing data disparities between developed and developing nations. She further emphasized that this is most essential because many public policies require economic measurements to achieve their goals, whether they are for growth, equality, or sustainability.
The research team has made the source code publicly available via GitHub and plans to continue improving the technology, applying it to new satellite images updated annually. The results of this study, with Ph.D. candidate Donghyun Ahn at KAIST and Ph.D. candidate Jeasurk Yang at NUS as joint first authors, were published in Nature Communications under the title "A human-machine collaborative approach measures economic development using satellite imagery."
< Photos of the main authors. 1. Donghyun Ahn, PhD candidate at KAIST School of Computing 2. Jeasurk Yang, PhD candidate at the Department of Geography of National University of Singapore 3. Meeyoung Cha, Professor of KAIST School of Computing and CI at IBS 4. Jihee Kim, Professor of KAIST School of Business and Technology Management 5. Sangyoon Park, Professor of the Division of Social Science at Hong Kong University of Science and Technology 6. Hyunjoo Yang, Professor of the Department of Economics at Sogang University >
2023.12.07 View 4586 -
The Relentless Rain: East Asia's Recent Floods and What Lies Beneath
In just a month's time, East Asia witnessed torrential downpours that would usually span an entire season. Japan, battered by three times its usual monthly rainfall, faced landslides and flooding that claimed over 200 lives. Meanwhile, South Korea grappled with its longest monsoon in seven years, leaving more than 40 individuals dead or missing. But these events, as harrowing as they sound, are more than just weather anomalies. They're telltale signs, symptoms of a larger malaise that has gripped our planet.
Diving deep into these rain-soaked mysteries, a recently published paper in the journal Science Advances offers a fresh perspective. Led by a research team at the Korea Advanced Institute of Science and Technology (KAIST), Korea, the research unpacks the influence of human-induced climate changes on the East Asia Summer Monsoon frontal system.
Heavy summer rain has a significant impact on agriculture and industry, and can be said to be one of the greatest threats to human society by causing disasters such as floods and landslides, affecting the local ecosystem. It has been reported from all over the world that the intensity of summer heavy rain has changed over the past few decades. However, summer rain in East Asia is caused by various forms such as typhoons, extratropical cyclones, and fronts, and efforts to study heavy frontal rain, which account for more than 40% of summer rainfall, is still insufficient. In addition, because heavy rain is also influenced by natural fluctuations or coincidences in the climate system, it is not yet known to what extent warming due to human activities affects the intensity of heavy frontal precipitation.
An international joint research team consisting of eight institutions from Korea, the United States, and Japan, including KAIST, Tokyo University, Tokyo Institute of Technology, Chonnam National University, GIST, and Utah State University, confirmed the intensity of heavy rain caused by the weather fronts in East Asia using observation data for the past 60 years and found that the coast of southeastern China. It was found that the intensity of heavy rain increased by about 17% across the Korean Peninsula and Japan. To investigate the cause of these changes, the research team used the Earth Metaverse experiment, which simulated Earth with and without greenhouse gas emissions due to human activities, and found that heavy rain intensity was strengthened by about 6% due to greenhouse gas emissions, and the changes discovered were has succeeded for the first time in the world in showing that warming cannot be explained without the effects of human activities.
< Figure 1. (Left) Observed difference in frontal rainfall intensity (FRI) from the later (1991–2015) to the earlier periods (1958–1982) (Right) Visualization of the impact of anthropogenic warming on the intensity of heavy frontal rain analyzed using the Earth Metaverse experiment. >
"It's not just about connecting the dots," said Moon, the first author of the paper, "it's about seeing the larger pattern. Our data analysis reveals a clear and intensified trend in East Asia's frontal rainfall, one that's intertwined with human actions and increasingly harmful for lives and property."
One of the intriguing finds from the study is the mechanics behind this intensification. The team found increased moisture transport due to a warmer climate, which, when coupled with the strengthening of a gigantic weather system called the West North Pacific Subtropical High, results in enhanced frontal rainfall. It’s akin to the climate dialing up the volume on rain events. As the atmosphere warms, it holds more moisture, leading to heavier downpours when conditions are right.
Nobuyuki Utsumi, another voice from the team, makes the science accessible for all, saying, "Monsoon rain isn't just rain anymore. The frequency, the intensity, it's changing. And our actions, our carbon footprint, are casting a larger shadow than we anticipated."
While the devastating news of floods fills headlines, Professor Simon Wang of Utah State University, reminds us of the underlying importance of their study. "It's like reading a detective novel. To solve the mystery of these floods, one has to trace them back to their roots. This work hints at a future where such intense rain events aren't the exception but might become an everyday reality."
Hyungjun Kim, the principal investigator of the team throws in a note of caution, "Understanding this is just the first step. Predicting and preparing for these extremes is the real challenge. Every amplified rainfall event is a message from the future, urging us to adapt." So far, predicting rainfall intensity and locations remains a challenging task for even the most sophisticated weather models.
< Figure 2. Comparison of rates of change in Anthropocene fingerprints. The horizontal axis shows the long-term change slope of the Anthropocene fingerprint signal (1958 to 2015). Shows the probability distribution of slopes extracted from the non-warming experiment (blue) and the warming experiment (red). The vertical solid lines are the slope of the Anthropocene fingerprint signal extracted from observational data. >
The researchers say, “Facing climate change, the narrative of this new study is more than mere numbers and data. It's a story of our planet, our actions, and the rain-soaked repercussions we're beginning to face. As we mop up the aftermath of another flood, research like Moon's beckons us to look deeper, understand better, and act wiser.”
< Figure 3. Comparison of water vapor convergence and rate of change of the western North Pacific high pressure. Shows the gradient of change in water vapor convergence (horizontal axis) and the Northwestern Pacific-East Asia pressure gradient (vertical axis) extracted from warming (red) and non-warming (blue) experiments. Shows the distribution of slope changes of the two indices during the period 1958 to 1982 (P1) and 1991 to 2015 (P2). >
The results of this study were published on November 24 in Science Advances. (Paper title: Anthropogenic warming induced intensification of summer monsoon frontal precipitation over East Asia)
This research was conducted with support from the National Research Foundation of Korea's Overseas Scientist Attraction Project (BP+) and the Anthropocene Research Center.
2023.12.05 View 3113 -
2023 Global Startup Internship Seminar (GSIS)
The Center for Global Strategies and Planning at KAIST hosted the 2023 Global Startup Internship Seminar (GSIS) both online and offline from November 29th to December 1st.
Following the success of the 2022 Global Startup Internship Fair (GSIF), the 2023 KAIST GSIS was organized in an enhanced format. This event provided students with the opportunity to explore internship opportunities with U.S. startups. Six startups in the fields of AI, bio, digital healthcare, drones, and e-commerce, Imprimed, Soundable Health, Vessl AI, B Garage, UNEEKOR, and Bringko, all founded by KAIST alumni, were invited. More than 80 KAIST students registered in advance to participate in the event.
The participating companies in this seminar shared who they and what they do and provided career mentoring for KAIST students. Catherine Song, the CEO of Soundable Health and a KAIST alumna, said, "It is very meaningful to introduce our company to KAIST students and provide them with the opportunity to take part in global internships."
In addition to startup company information and mentoring sessions, the seminar included sessions on preparing CVs, cover letters, and business emails for U.S. internships, and how to settle in Silicon Valley. Internship experiences were also shared by current KAIST students. Finally, a J-1 visa information session was conducted, providing useful tips for students preparing for U.S. internships.
Man-Sung Yim, the Vice President of the International Office at KAIST, said, "We hope that KAIST students, who have nurtured a global entrepreneurial spirit through this event, will grow into aspiring entrepreneurs with confidence on the global stage." He also mentioned plans to leverage the success of this event by connecting it with other KAIST global entrepreneurship programs.
2023.12.05 View 3475 -
An intravenous needle that irreversibly softens via body temperature on insertion
- A joint research team at KAIST developed an intravenous (IV) needle that softens upon insertion, minimizing risk of damage to blood vessels and tissues.
- Once used, it remains soft even at room temperature, preventing accidental needle stick injuries and unethical multiple use of needle.
- A thin-film temperature sensor can be embedded with this needle, enabling real-time monitoring of the patient's core body temperature, or detection of unintended fluid leakage, during IV medication.
Intravenous (IV) injection is a method commonly used in patient’s treatment worldwide as it induces rapid effects and allows treatment through continuous administration of medication by directly injecting drugs into the blood vessel. However, medical IV needles, made of hard materials such as stainless steel or plastic which do not mechanically match the soft biological tissues of the body, can cause critical problems in healthcare settings, starting from minor tissue damages in the injection sites to serious inflammations.
The structure and dexterity of rigid medical IV devices also enable unethical reuse of needles for reduction of injection costs, leading to transmission of deadly blood-borne disease infections such as human immunodeficiency virus (HIV) and hepatitis B/C viruses. Furthermore, unintended needlestick injuries are frequently occurring in medical settings worldwide, that are viable sources of such infections, with IV needles having the greatest susceptibility of being the medium of transmissible diseases. For these reasons, the World Health Organization (WHO) in 2015 launched a policy on safe injection practices to encourage the development and use of “smart” syringes that have features to prevent re-use, after a tremendous increase in the number of deadly infectious disease worldwide due to medical-sharps related issues.
KAIST announced on the 13th that Professor Jae-Woong Jeong and his research team of its School of Electrical Engineering succeeded in developing the Phase-Convertible, Adapting and non-REusable (P-CARE) needle with variable stiffness that can improve patient health and ensure the safety of medical staff through convergent joint research with another team led by Professor Won-Il Jeong of the Graduate School of Medical Sciences.
The new technology is expected to allow patients to move without worrying about pain at the injection site as it reduces the risk of damage to the wall of the blood vessel as patients receive IV medication. This is possible with the needle’s stiffness-tunable characteristics which will make it soft and flexible upon insertion into the body due to increased temperature, adapting to the movement of thin-walled vein. It is also expected to prevent blood-borne disease infections caused by accidental needlestick injuries or unethical re-using of syringes as the deformed needle remains perpetually soft even after it is retracted from the injection site.
The results of this research, in which Karen-Christian Agno, a doctoral researcher of the School of Electrical Engineering at and Dr. Keungmo Yang of the Graduate School of Medical Sciences participated as co-first authors, was published in Nature Biomedical Engineering on October 30. (Paper title: A temperature-responsive intravenous needle that irreversibly softens on insertion)
< Figure 1. Disposable variable stiffness intravenous needle. (a) Conceptual illustration of the key features of the P-CARE needle whose mechanical properties can be changed by body temperature, (b) Photograph of commonly used IV access devices and the P-CARE needle, (c) Performance of common IV access devices and the P-CARE needle >
“We’ve developed this special needle using advanced materials and micro/nano engineering techniques, and it can solve many global problems related to conventional medical needles used in healthcare worldwide”, said Jae-Woong Jeong, Ph.D., an associate professor of Electrical Engineering at KAIST and a lead senior author of the study.
The softening IV needle created by the research team is made up of liquid metal gallium that forms the hollow, mechanical needle frame encapsulated within an ultra-soft silicone material. In its solid state, gallium has sufficient hardness that enables puncturing of soft biological tissues. However, gallium melts when it is exposed to body temperature upon insertion, and changes it into a soft state like the surrounding tissue, enabling stable delivery of the drug without damaging blood vessels. Once used, a needle remains soft even at room temperature due to the supercooling phenomenon of gallium, fundamentally preventing needlestick accidents and reuse problems.
Biocompatibility of the softening IV needle was validated through in vivo studies in mice. The studies showed that implanted needles caused significantly less inflammation relative to the standard IV access devices of similar size made of metal needles or plastic catheters. The study also confirmed the new needle was able to deliver medications as reliably as commercial injection needles.
< Photo 1. Photo of the P-CARE needle that softens with body temperature. >
Researchers also showed possibility of integrating a customized ultra-thin temperature sensor with the softening IV needle to measure the on-site temperature which can further enhance patient’s well-being. The single assembly of sensor-needle device can be used to monitor the core body temperature, or even detect if there is a fluid leakage on-site during indwelling use, eliminating the need for additional medical tools or procedures to provide the patients with better health care services.
The researchers believe that this transformative IV needle can open new opportunities for wide range of applications particularly in clinical setups, in terms of redesigning other medical needles and sharp medical tools to reduce muscle tissue injury during indwelling use. The softening IV needle may become even more valuable in the present times as there is an estimated 16 billion medical injections administered annually in a global scale, yet not all needles are disposed of properly, based on a 2018 WHO report.
< Figure 2. Biocompatibility test for P-CARE needle: Images of H&E stained histology (the area inside the dashed box on the left is provided in an expanded view in the right), TUNEL staining (green), DAPI staining of nuclei (blue) and co-staining (TUNEL and DAPI) of muscle tissue from different organs. >
< Figure 3. Conceptual images of potential utilization for temperature monitoring function of P-CARE needle integrated with a temperature sensor. >
(a) Schematic diagram of injecting a drug through intravenous injection into the abdomen of a laboratory mouse (b) Change of body temperature upon injection of drug (c) Conceptual illustration of normal intravenous drug injection (top) and fluid leakage (bottom) (d) Comparison of body temperature during normal drug injection and fluid leakage: when the fluid leak occur due to incorrect insertion, a sudden drop of temperature is detected.
This work was supported by grants from the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT.
2023.11.13 View 5757 -
KAIST proposes alternatives to chemical factories through “iBridge”
- A computer simulation program “iBridge” was developed at KAIST that can put together microbial cell factories quickly and efficiently to produce cosmetics and food additives, and raw materials for nylons
- Eco-friendly and sustainable fermentation process to establish an alternative to chemical plants
As climate change and environmental concerns intensify, sustainable microbial cell factories garner significant attention as candidates to replace chemical plants. To develop microorganisms to be used in the microbial cell factories, it is crucial to modify their metabolic processes to induce efficient target chemical production by modulating its gene expressions. Yet, the challenge persists in determining which gene expressions to amplify and suppress, and the experimental verification of these modification targets is a time- and resource-intensive process even for experts. The challenges were addressed by a team of researchers at KAIST (President Kwang-Hyung Lee) led by Distinguished Professor Sang Yup Lee.
It was announced on the 9th by the school that a method for building a microbial factory at low cost, quickly and efficiently, was presented by a novel computer simulation program developed by the team under Professor Lee’s guidance, which is named “iBridge”. This innovative system is designed to predict gene targets to either overexpress or downregulate in the goal of producing a desired compound to enable the cost-effective and efficient construction of microbial cell factories specifically tailored for producing the chemical compound in demand from renewable biomass.
Systems metabolic engineering is a field of research and engineering pioneered by KAIST’s Distinguished Professor Sang Yup Lee that seeks to produce valuable compounds in industrial demands using microorganisms that are re-configured by a combination of methods including, but not limited to, metabolic engineering, synthetic biology, systems biology, and fermentation engineering.
In order to improve microorganisms’ capability to produce useful compounds, it is essential to delete, suppress, or overexpress microbial genes. However, it is difficult even for the experts to identify the gene targets to modify without experimental confirmations for each of them, which can take up immeasurable amount of time and resources.
The newly developed iBridge identifies positive and negative metabolites within cells, which exert positive and/or negative impact on formation of the products, by calculating the sum of covariances of their outgoing (consuming) reaction fluxes for a target chemical. Subsequently, it pinpoints "bridge" reactions responsible for converting negative metabolites into positive ones as candidates for overexpression, while identifying the opposites as targets for downregulation.
The research team successfully utilized the iBridge simulation to establish E. coli microbial cell factories each capable of producing three of the compounds that are in high demands at a production capacity that has not been reported around the world. They developed E. coli strains that can each produce panthenol, a moisturizing agent found in many cosmetics, putrescine, which is one of the key components in nylon production, and 4-hydroxyphenyllactic acid, an anti-bacterial food additive. In addition to these three compounds, the study presents predictions for overexpression and suppression genes to construct microbial factories for 298 other industrially valuable compounds.
Dr. Youngjoon Lee, the co-first author of this paper from KAIST, emphasized the accelerated construction of various microbial factories the newly developed simulation enabled. He stated, "With the use of this simulation, multiple microbial cell factories have been established significantly faster than it would have been using the conventional methods. Microbial cell factories producing a wider range of valuable compounds can now be constructed quickly using this technology."
Professor Sang Yup Lee said, "Systems metabolic engineering is a crucial technology for addressing the current climate change issues." He added, "This simulation could significantly expedite the transition from resorting to conventional chemical factories to utilizing environmentally friendly microbial factories."
< Figure. Conceptual diagram of the flow of iBridge simulation >
The team’s work on iBridge is described in a paper titled "Genome-Wide Identification of Overexpression and Downregulation Gene Targets Based on the Sum of Covariances of the Outgoing Reaction Fluxes" written by Dr. Won Jun Kim, and Dr. Youngjoon Lee of the Bioprocess Research Center and Professors Hyun Uk Kim and Sang Yup Lee of the Department of Chemical and Biomolecular Engineering of KAIST. The paper was published via peer-review on the 6th of November on “Cell Systems” by Cell Press.
This research was conducted with the support from the Development of Platform Technologies of Microbial Cell Factories for the Next-generation Biorefineries Project (Project Leader: Distinguished Professor Sang Yup Lee, KAIST) and Development of Platform Technology for the Production of Novel Aromatic Bioplastic using Microbial Cell Factories Project (Project Leader: Research Professor So Young Choi, KAIST) of the Korean Ministry of Science and ICT.
2023.11.09 View 4338 -
NYU-KAIST Global AI & Digital Governance Conference Held
< Photo 1. Opening of NYU-KAIST Global AI & Digital Governance Conference >
In attendance of the Minister of Science and ICT Jong-ho Lee, NYU President Linda G. Mills, and KAIST President Kwang Hyung Lee, KAIST co-hosted the NYU-KAIST Global AI & Digital Governance Conference at the Paulson Center of New York University (NYU) in New York City, USA on September 21st, 9:30 pm.
At the conference, KAIST and NYU discussed the direction and policies for ‘global AI and digital governance’ with participants of upto 300 people which includes scholars, professors, and students involved in the academic field of AI and digitalization from both Korea and the United States and other international backgrounds. This conference was a forum of an international discussion that sought new directions for AI and digital technology take in the future and gathered consensus on regulations.
Following a welcoming address by KAIST President, Kwang Hyung Lee and a congratulatory message from the Minister of Science and ICT, Jong-ho Lee, a panel discussion was held, moderated by Professor Matthew Liao, a graduate of Princeton and Oxford University, currently serving as a professor at NYU and the director at the Center for Bioethics of the NYU School of Global Public Health.
Six prominent scholars took part in the panel discussion. Prof. Kyung-hyun Cho of NYU Applied Mathematics and Data Science Center, a KAIST graduate who has joined the ranks of the world-class in AI language models and Professor Jong Chul Ye, the Director of Promotion Council for Digital Health at KAIST, who is leading innovative research in the field of medical AI working in collaboration with major hospitals at home and abroad was on the panel. Additionally, Professor Luciano Floridi, a founding member of the Yale University Center for Digital Ethics, Professor Shannon Vallor, the Baillie Gifford Professor in the Ethics of Data and Artificial Intelligence at the University of Edinburgh of the UK, Professor Stefaan Verhulst, a Co-Founder and the DIrector of GovLab‘s Data Program at NYU’s Tandon School of Engineering, and Professor Urs Gasser, who is in charge of public policy, governance and innovative technology at the Technical University of Munich, also participated.
Professor Matthew Liao from NYU led the discussion on various topics such as the ways to to regulate AI and digital technologies; the concerns about how deep learning technology being developed in medicinal purposes could be used in warfare; the scope of responsibilities Al scientists' responsibility should carry in ensuring the usage of AI are limited to benign purposes only; the effects of external regulation on the AI model developers and the research they pursue; and on the lessons that can be learned from the regulations in other fields.
During the panel discussion, there was an exchange of ideas about a system of standards that could harmonize digital development and regulatory and social ethics in today’s situation in which digital transformation accelerates technological development at a global level, there is a looming concern that while such advancements are bringing economic vitality it may create digital divides and probles like manipulation of public opinion. Professor Jong-cheol Ye of KAIST (Director of the Promotion Council for Digital Health), in particular, emphasized that it is important to find a point of balance that does not hinder the advancements rather than opting to enforcing strict regulations.
< Photo 2. Panel Discussion in Session at NYU-KAIST Global AI & Digital Governance Conference >
KAIST President Kwang Hyung Lee explained, “At the Digital Governance Forum we had last October, we focused on exploring new governance to solve digital challenges in the time of global digital transition, and this year’s main focus was on regulations.”
“This conference served as an opportunity of immense value as we came to understand that appropriate regulations can be a motivation to spur further developments rather than a hurdle when it comes to technological advancements, and that it is important for us to clearly understand artificial intelligence and consider what should and can be regulated when we are to set regulations on artificial intelligence,” he continued.
Earlier, KAIST signed a cooperation agreement with NYU to build a joint campus, June last year and held a plaque presentation ceremony for the KAIST NYU Joint Campus last September to promote joint research between the two universities. KAIST is currently conducting joint research with NYU in nine fields, including AI and digital research. The KAIST-NYU Joint Campus was conceived with the goal of building an innovative sandbox campus centering aroung science, technology, engineering, and mathematics (STEM) combining NYU's excellent humanities and arts as well as basic science and convergence research capabilities with KAIST's science and technology.
KAIST has contributed to the development of Korea's industry and economy through technological innovation aiding in the nation’s transformation into an innovative nation with scientific and technological prowess. KAIST will now pursue an anchor/base strategy to raise KAIST's awareness in New York through the NYU Joint Campus by establishing a KAIST campus within the campus of NYU, the heart of New York.
2023.09.22 View 5723 -
KAIST holds its first ‘KAIST Tech Fair’ in New York, USA
< Photo 1. 2023 KAIST Tech Fair in New York >
KAIST (President Kwang-Hyung Lee) announced on the 11th that it will hold the ‘2023 KAIST Tech Fair in New York’ at the Kimmel Center at New York University in Manhattan, USA, on the 22nd of this month. It is an event designed to be the starting point for KAIST to expand its startup ecosystem into the global stage, and it is to attract investments and secure global customers in New York by demonstrating the technological value of KAIST startup companies directly at location.
< Photo 2. President Kwang Hyung Lee at the 2023 KAIST Tech Fair in New York >
KAIST has been holding briefing sessions for technology transfer in Korea every year since 2018, and this year is the first time to hold a tech fair overseas for global companies.
KAIST Institute of Technology Value Creation (Director Sung-Yool Choi) has prepared for this event over the past six months with the Korea International Trade Association (hereinafter KITA, CEO Christopher Koo) to survey customer base and investment companies to conduct market analysis.
Among the companies founded with the technologies developed by the faculty and students of KAIST and their partners, 7 companies were selected to be matched with companies overseas that expressed interests in these technologies. Global multinational companies in the fields of IT, artificial intelligence, environment, logistics, distribution, and retail are participating as demand agencies and are testing the marketability of the start-up's technology as of September.
Daim Research, founded by Professor Young Jae Jang of the Department of Industrial and Systems Engineering, is a company specializing in smart factory automation solutions and is knocking on the door of the global market with a platform technology optimized for automated logistics systems.
< Photo 3. Presentation by Professor Young Jae Jang for DAIM Research >
It is a ‘collaborative intelligence’ solution that maximizes work productivity by having a number of robots used in industrial settings collaborate with one another. The strength of their solution is that logistics robots equipped with AI reinforced learning technology can respond to processes and environmental changes on their own, minimizing maintenance costs and the system can achieve excellent performance even with a small amount of data when it is combined with the digital twin technology the company has developed on its own.
A student startup, ‘Aniai’, is entering the US market, the home of hamburgers, with hamburger patty automation equipments and solutions. This is a robot kitchen startup founded by its CEO Gunpil Hwang, a graduate of KAIST’s School of Electrical Engineering which gathered together the experts in the fields of robot control, design, and artificial intelligence and cognitive technology to develop technology to automatically cook hamburger patties.
At the touch of a button, both sides of the patty are cooked simultaneously for consistent taste and quality according to the set condition. Since it can cook about 200 dishes in an hour, it is attracting attention as a technology that can not only solve manpower shortages but also accelerate the digital transformation of the restaurant industry.
Also, at the tech fair to be held at the Kimmel Center of New York University on the 22nd, the following startups who are currently under market verification in the U.S. will be participating: ▴'TheWaveTalk', which developed a water quality management system that can measure external substances and metal ions by transferring original technology from KAIST; ▴‘VIRNECT’, which helps workers improve their skills by remotely managing industrial sites using XR*; ▴‘Datumo’, a solution that helps process and analyze artificial intelligence big data, ▴‘VESSL AI’, the provider of a solution to eliminate the overhead** of machine learning systems; and ▴ ‘DolbomDream’, which developed an inflatable vest that helps the psychological stability of people with developmental disabilities.
* XR (eXtended Reality): Ultra-realistic technology that enhances immersion by utilizing augmented reality, virtual reality, and mixed reality technologies
** Overhead: Additional time required for stable processing of the program
In addition, two companies (Plasmapp and NotaAI) that are participating in the D-Unicorn program with the support of the Daejeon City and two companies (Enget and ILIAS Biologics) that are receiving support from the Scale Up Tips of the Ministry of SMEs and Startups, three companies (WiPowerOne, IDK Lab, and Artificial Photosynthesis Lab) that are continuing to realize the sustainable development goals for a total of 14 KAIST startups, will hold a corporate information session with about 100 invited guests from global companies and venture capital.
< Photo 4. Presentation for AP Lab >
Prior to this event, participating startups will be visiting the New York Economic Development Corporation and large law firms to receive advice on U.S. government support programs and on their attemps to enter the U.S. market. In addition, the participating companies plan to visit a startup support investment institution pursuing sustainable development goals and the Leslie eLab, New York University's one-stop startup support space, to lay the foundation for KAIST's leap forward in global technology commercialization.
< Photo 5. Sung-Yool Choi, the Director of KAIST Institute of Technology Value Creation (left) at the 2023 KAIST Tech Fair in New York with the key participants >
Sung-Yool Choi, the Director of KAIST Institute of Technology Value Creation, said, “KAIST prepared this event to realize its vision of being a leading university in creating global value.” He added, “We hope that our startups founded with KAIST technology would successfully completed market verification to be successful in securing global demands and in attracting investments for their endeavors.”
2023.09.11 View 9716