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KAIST Holds Robot Taekwondo Competition Recognized by the World Taekwondo Federation
KAIST will host the 12th Intelligent System-on-Chip (SoC) Robot War in October 2013, a robot competition. The event will have two entries: robot Taekwondo contest and HURO competition.
The World Taekwondo Federation has decided to offer an honorary Taekwondo degree to the winner of SoC Taekwondo Robot competition.
The Intelligent SoC Robot War was created in 2002 by KAIST’s Professor Hoi-Jun Yoo in the Department of Electrical Engineering.
For SoC Taekwondo Robot event, two robots compete in the form of Taekwondo, traditional Korean martial arts. The robots competing in this event have a camera and semiconductor chips on board, and therefore they have the brain-like functions to identify an object and control movements on their own. The robots have 21 joints with humanoid robot technology on their body for the techniques needed to compete in a typical Taekwondo match. They employ moves such as front kicks, side kicks, and upper punches.
In particular, KAIST’s System Design Innovation & Application Research Center, the organizer of this competition, has operated a team to demonstrate robot Taekwondo since last year with the purpose of displaying the basic movements of Taekwondo.
“Robots received attention as the source of growth in the near future. We have been developing robotics technology, and as part of our endeavor, preparing the Taekwondo demonstration team since 2012 to exhibit Korea’s robot technology and introduce our traditional martial arts,” said Professor Hoi-Jun Yoo. “We will continue to develop various capabilities for Taekwondo robots in cooperation with the World Taekwondo Federation.”
In HURO-Competition, robots compete for crossing the finishing line first by completing various missions, such as putting in a golf ball or overcoming obstacles while avoiding unexpected accidents. The winning team is awarded with a Presidential Award of Korea.
The 12th Intelligent SoC Robot War Competition is open to all graduate or undergraduate students. For details, visit the homepage at http://www.socrobotwar.org/.
2013.05.06 View 9964 -
Distinguished Professor Sang-Yup Lee received 2013 Amgen Biochemical Engineering Award
- Previous award winners are world-renowned scholars of biochemical engineering including James Bailey, Michael Shuler and Daniel Wang
KAIST Chemical and Biomolecular Engineering Department’s Professor Sang-Yup Lee has been selected to receive the 2013 Amgen Biochemical Engineering Award. The award ceremony will take place this June at the International Biochemical and Molecular Engineering conference in Beijing, China.
The Amgen Biochemical Engineering Award was established by Amgen, a world renowned American pharmaceutical company, in 1993. Amgen awards leading biochemical engineers every two years. The first Amgen award recipient was James Bailey of the California Institute of Technology (Caltech) in 1993. Since then leading engineers that are sometimes called “founding fathers of biochemical engineering” have received the award including MIT Professor Daniel Wang and Michael Shuler of Cornell University.
The first nine award winners were Americans and in 2011 Jens Nielson of Chalmers University of Technology, Sweden, received the Amgen award as a non-American. Professor Sang-Yup Lee is the first Asian to receive the award.
The Amgen award panel said, “Professor Lee made an incredible contribution to the fields of synthetic biology and industrial bioengineering by finding chemical material, fuel, protein and drug production and system bioengineering through metabolic engineering of microorganisms.”
Professor Lee is an expert in metabolic engineering of microorganisms and contributed to the development of system metabolic engineering and system bioengineering. Furthermore, he developed various medical and chemical products and processes which were then applied to synthesise strains of succinate, plastics, butanol and nylon.
Professor Lee is a fellow of the Korean Academy of Science and Technology and National Academy Engineering of Korea; an international member of National Academy of Engineering (US); a former fellow of the American Association for the Advancement of Science; a member of the American Institute of Chemical Engineers, the American Industrial Microbiology Society and American Academy of Microbiology. He is currently Head of Global Agenda Council on Biotechnology and is world renowned for his work in biotechnology field.
2013.04.30 View 8161 -
The new era of personalized cancer diagnosis and treatment
Professor Tae-Young Yoon
- Succeeded in observing carcinogenic protein at the molecular level
- “Paved the way to customized cancer treatment through accurate analysis of carcinogenic protein”
The joint KAIST research team of Professor Tae Young Yoon of the Department of Physics and Professor Won Do Huh of the Department of Biological Sciences have developed the technology to monitor characteristics of carcinogenic protein in cancer tissue – for the first time in the world.
The technology makes it possible to analyse the mechanism of cancer development through a small amount of carcinogenic protein from a cancer patient. Therefore, a personalised approach to diagnosis and treatment using the knowledge of the specific mechanism of cancer development in the patient may be possible in the future.
Until recently, modern medicine could only speculate on the cause of cancer through statistics. Although developed countries, such as the United States, are known to use a large sequencing technology that analyses the patient’s DNA, identification of the interactions between proteins responsible for causing cancer remained an unanswered question for a long time in medicine.
Firstly, Professor Yoon’s research team has developed a fluorescent microscope that can observe even a single molecule. Then, the “Immunoprecipitation method”, a technology to extract a specific protein exploiting the high affinity between antigens and antibodies was developed. Using this technology and the microscope, “Real-Time Single Molecule co-Immunoprecipitation Method” was created. In this way, the team succeeded in observing the interactions between carcinogenic and other proteins at a molecular level, in real time.
To validate the developed technology, the team investigated Ras, a carcinogenic protein; its mutation statistically is known to cause around 30% of cancers.
The experimental results confirmed that 30-50% of Ras protein was expressed in mouse tumour and human cancer cells. In normal cells, less than 5% of Ras protein was expressed. Thus, the experiment showed that unusual increase in activation of Ras protein induces cancer.
The increase in the ratio of active Ras protein can be inferred from existing research data but the measurement of specific numerical data has never been done before.
The team suggested a new molecular level diagnosis technique of identifying the progress of cancer in patients through measuring the percentage of activated carcinogenic protein in cancer tissue.
Professor Yoon Tae-young said, “This newly developed technology does not require a separate procedure of protein expression or refining, hence the existing proteins in real biological tissues or cancer cells can be observed directly.” He also said, “Since carcinogenic protein can be analyzed accurately, it has opened up the path to customized cancer treatment in the future.”
“Since the observation is possible on a molecular level, the technology confers the advantage that researchers can carry out various examinations on a small sample of the cancer patient.” He added, “The clinical trial will start in December 2012 and in a few years customized cancer diagnosis and treatment will be possible.”
Meanwhile, the research has been published in Nature Communications (February 19). Many researchers from various fields have participated, regardless of the differences in their speciality, and successfully produced interdisciplinary research. Professor Tae Young Yoon of the Department of Physics and Professors Dae Sik Lim and Won Do Huh of Biological Sciences at KAIST, and Professor Chang Bong Hyun of Computational Science of KIAS contributed to developing the technique.
Figure 1: Schematic diagram of observed interactions at the molecular level in real time using fluorescent microscope. The carcinogenic protein from a mouse tumour is fixed on the microchip, and its molecular characteristics are observed live.
Figure 2: Molecular interaction data using a molecular level fluorescent microscope. A signal in the form of spike is shown when two proteins combine. This is monitored live using an Electron Multiplying Charge Coupled Device (EMCCD). It shows signal results in bright dots.
An organism has an immune system as a defence mechanism to foreign intruders. The immune system is activated when unwanted pathogens or foreign protein are in the body. Antibodies form in recognition of the specific antigen to protect itself. Organisms evolved to form antibodies with high specificity to a certain antigen. Antibodies only react to its complementary antigens. The field of molecular biology uses the affinity between antigens and antibodies to extract specific proteins; a technology called immunoprecipitation. Even in a mixture of many proteins, the protein sought can be extracted using antibodies. Thus immunoprecipitation is widely used to detect pathogens or to extract specific proteins.
Technology co-IP is a well-known example that uses immunoprecipitation. The research on interactions between proteins uses co-IP in general. The basis of fixing the antigen on the antibody to extract antigen protein is the same as immunoprecipitation. Then, researchers inject and observe its reaction with the partner protein to observe the interactions and precipitate the antibodies. If the reaction occurs, the partner protein will be found with the antibodies in the precipitations. If not, then the partner protein will not be found. This shows that the two proteins interact.
However, the traditional co-IP can be used to infer the interactions between the two proteins although the information of the dynamics on how the reaction occurs is lost. To overcome these shortcomings, the Real-Time Single Molecule co-IP Method enables observation on individual protein level in real time. Therefore, the significance of the new technique is in making observation of interactions more direct and quantitative.
Additional Figure 1: Comparison between Conventional co-IP and Real-Time Single Molecule co-IP
2013.04.01 View 17172 -
Ligand Recognition Mechanism of Protein Identified
Professor Hak-Sung Kim
-“Solved the 50 year old mystery of how protein recognises and binds to ligands”
- Exciting potential for understanding life phenomena and the further development of highly effective therapeutic agent development
KAIST’s Biological Science Department’s Professor Hak-Sung Kim, working in collaboration with Professor Sung-Chul Hong of Department of Physics, Seoul National University, has identified the mechanism of how the protein recognizes and binds to ligands within the human body.
The research findings were published in the online edition of Nature Chemical Biology (March 18), which is the most prestigious journal in the field of life science.
Since the research identified the mechanism, of which protein recognises and binds to ligands, it will take an essential role in understanding complex life phenomenon by understanding regulatory function of protein.
Also, ligand recognition of proteins is closely related to the cause of various diseases. Therefore the research team hopes to contribute to the development of highly effective treatments.
Ligands, well-known examples include nucleic acid and proteins, form the structure of an organism or are essential constituents with special functions such as information signalling.
In particular, the most important role of protein is recognising and binding to a particular ligand and hence regulating and maintaining life phenomena. The abnormal occurrence of an error in recognition of ligands may lead to various diseases.
The research team focused on the repetition of change in protein structure from the most stable “open form” to a relatively unstable “partially closed form”.
Professor Kim’s team analysed the change in protein structure when binding to a ligand on a molecular level in real time to explain the ligand recognition mechanism.
The research findings showed that ligands prefer the most stable protein structure. The team was the first in the world to identify that ligands alter protein structure to the most stable, the lowest energy level, when it binds to the protein.
In addition, the team found that ligands bind to unstable partially-closed forms to change protein structure.
The existing models to explain ligand recognition mechanism of protein are “Induced Custom Model”, which involves change in protein structure in binding to ligands, and the “Structure Selection Model”, which argues that ligands select and recognise only the best protein structure out of many. The academic world considers that the team’s research findings have perfectly proved the models through experiments for the first time in the world.
Professor Kim explained, “In the presence of ligands, there exists a phenomenon where the speed of altering protein structure is changed. This phenomenon is analysed on a molecular level to prove ligand recognition mechanism of protein for the first time”. He also said, “The 50-year old mystery, that existed only as a hypothesis on biology textbooks and was thought never to be solved, has been confirmed through experiments for the first time.”
Figure 1: Proteins, with open and partially open form, recognising and binding to ligands.
Figure 2: Ligands temporarily bind to a stable protein structure, open form, which changes into the most stable structure, closed form. In addition, binding to partially closed form also changes protein structure to closed form.
2013.04.01 View 10363 -
KAIST and Saudi Aramco agreed to establish a joint CO2 research center in Korea
The Korea Advanced Institute of Science and Technology (KAIST) and Saudi Aramco, a global energy and petrochemicals enterprise, signed a memorandum of understanding (MOU) on January 6, 2013 in Dhahran, Saudi Arabia and pledged to jointly collaborate in research and development of innovative technologies and solutions to address the world"s energy challenges.
Under the MOU, the two entities agreed to establish a research center, Saudi Aramco-KAIST CO2 Research Center, near KAIST"s main campus in Daejeon, Korea. The research center, to be jointly managed by KAIST and Saudi Aramco, will foster and facilitate research collaborations in areas such as tackling carbon dioxide (CO2) emissions by removal or capture of CO2, conversing CO2 into useful products, developing efficiency improvements in energy production, sharing carbon management technologies, establishing exchange programs, and conducting joint projects.
According to Saudi Aramco, the company"s collaboration with KAIST is the first partnership established in Asia. Khalid A. Al-Falih, President and CEO of Saudi Aramco, said,
"The CO2 Research Center represents a major step in Saudi Aramco"s research and technology strategy to partner with top global institutions to help address and find sustainable solutions to the world’s energy challenge both domestically and internationally."
2013.03.19 View 9139 -
New Technology Will Enable the Commercialization of Plasmon Displays
-- Enhancements in the penetration ratios of color filters are expected by applying nano-surface plasmon effects. --
-- Color filter technology will be applicable to large-area OLED and LCD. --
The fabrication technology to commercialize display color filters using plasmon effects has been discovered.
A joint research team headed by Professor Kyung Cheol Choi from the Department of Electrical Engineering of the Korea Advanced Institute for Science and Technology and Prof. Byeong-Kwon Ju from the School of Electrical Engineering of Korea University has developed the technology to design and produce a display color filter by applying nano-surface plasmon effects.
Color filters are core components used to express colors in CMOS image sensors found in LCD/OLED displays or digital cameras. The current color filters have penetration ratios of 20~30%, but the objective of the joint research team is to raise this penetration ratio by over 40% to facilitate the mass production of energy-efficient plasmonic displays.
Currently available plasmonic color filters are limited to applications on micrometer scales. However, outcomes of the newest research extend the size of the applications up to 2.5 cm by using laser interference lithography. The academic and industrial sectors agree that it is now possible to mass-produce displays using plasmonic color filters.
The researchers built a nanohole array to large scale by using laser interference lithography, a technology that forms nanostructures with laser light interferences. They also suggested a new manufacturing process that can optimize the features of color filters while compensating for defects arising from the fabrication stages.
The new manufacturing process of applying laser interference lithography is expected to overcome the shortcomings of traditional color filters by simplifying production and, enabling them to be produced at lower costs.
“There were limitations to industrial applications of plasmon effect due to production costs, time, and yields,” explained Yun Seon Do, a Ph. D. candidate in the Department of Electrical Engineering of KAIST. “The new technology can reduce fabrication time and cost to the extent that it would be advisable to replace dye-based and pigment-based color filter technology."
“This research can be applied to large-scale displays, such as TV screens, by using laser-interference lithography,” said Jung-Ho Park, a Ph. D. candidate in the School of Electrical Engineering of Korea University. “The research outcome is expected to be widely applied in advanced nano-manufacturing processes as it does not restrict the types of circuit boards."
The research outcome, led by doctoral candidates Do and Park, appeared on the front cover of the second issue of Advanced Optical Materials, a highly regarded academic journal in the field of nanotechnologies, and the team has applied for six related patents.
2013.03.13 View 8363 -
Synthesis of a New Organic Supermolecule Succeeded
From left to right: Prof.Stoddart, Prof.Goddard and Prof.Jang Wook Choi
KAIST EEWS graduate school’s research team led by Prof. Stoddart, Prof. Goddard and Prof. Jang Wook Choi has succeeded the synthesis of a new organic supermolecule that is stable in a radical condition under room temperature.
Prof. Stoddart, who mainly led this research, is the world’s great scholar on orgaic molecular structure especially on catenane with an interconnection of several ring structures. Catenane is originated from Latin “catenane” referring to “chain”. The brief structure of the synthesized catenane is as following:
Usually radicals are known to be unstable since they are electronically neutral and have very high reactivity. However, the radicals from this research showed air- and water- stability. It also showed a reversible change in oxidation number from o to +8 through chemical/electrochemical oxidation-reduction reaction. The phenomenon where paramagnetic and diamagnetic characteristics change according to the oxidation number has also been observed.
Thus, the research like this - on the molecules showing various characteristics with stable radical - is expected to give a new direction to the next-generation electromemory system, semiconductor and energy storage system research.
Meanwhile, this research, led by Prof.Stoddart team with Prof.Goddard and Prof. Jang Wook Choi’s team, is conducted under the support of Science and Technology’s World Class University project by Ministry of Education and published in ‘Science’ on 25th of Jan.
2013.02.24 View 9950
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Online Article on President Sung-Mo 'Steve' Kang by California Council on Science and Technology (CCST)
The California Council on Science and Technology (CCST), an independent, not-for-profit organization established by the mandate of California Legislature in 1988, is designed to offer expert advice to the California state government and recommend solutions to science and technology-related policy issues.
Over the past three years, President Sung-Mo “Steve” Kang has served as a member of CCST Council, an assembly of corporate CEOs, academicians, scientists, and scholars of the highest distinction.
On February 21, 2013, CCST posted on its website the announcement of Council Member Sung-Mo “Steve” Kang as President of KAIST along with his personal comments on his move to KAIST and its presidency. For the online article, please visit: http://www.ccst.us/news/2013/0221KAIST.php
2013.02.23 View 7571
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New BioFactory Technique Developed using sRNAs
Professor Sang Yup Lee
- published on the online edition of Nature Biotechnology. “Expected as a new strategy for the bio industry that may replace the chemical industry.”-
KAIST Chemical & Biomolecular engineering department’s Professor Sang Yup Lee and his team has developed a new technology that utilizes the synthetic small regulatory RNAs (sRNAs) to implement the BioFactory in a larger scale with more effectiveness.
* BioFactory: Microbial-based production system which creates the desired compound in mass by manipulating the genes of the cell.
In order to solve the problems of modern society, such as environmental pollution caused by the exhaustion of fossil fuels and usage of petrochemical products, an eco-friendly and sustainable bio industry is on the rise. BioFactory development technology has especially attracted the attention world-wide, with its ability to produce bio-energy, pharmaceuticals, eco-friendly materials and more.
For the development of an excellent BioFactory, selection for the gene that produces the desired compounds must be accompanied by finding the microorganism with high production efficiency; however, the previous research method had a complicated and time-consuming problem of having to manipulate the genes of the microorganism one by one.
Professor Sang Yup Lee’s research team, including Dr. Dokyun Na and Dr. Seung Min Yoo, has produced the synthetic sRNAs and utilized it to overcome the technical limitations mentioned above.
In particular, unlike the existing method, this technology using synthetic sRNAs exhibits no strain specificity which can dramatically shorten the experiment that used to take months to just a few days.
The research team applied the synthetic small regulatory RNA technology to the production of the tyrosine*, which is used as the precursor of the medicinal compound, and cadaverine**, widely utilized in a variety of petrochemical products, and has succeeded developing BioFactory with the world’s highest yield rate (21.9g /L, 12.6g / L each).
*tyrosine: amino acid known to control stress and improve concentration
**cadaverine: base material used in many petrochemical products, such as polyurethane
Professor Sang Yup Lee highlighted the significance of this research: “it is expected the synthetic small regulatory RNA technology will stimulate the BioFactory development and also serve as a catalyst which can make the chemical industry, currently represented by its petroleum energy, transform into bio industry.”
The study was carried out with the support of Global Frontier Project (Intelligent Bio-Systems Design and Synthesis Research Unit (Chief Seon Chang Kim)) and the findings have been published on January 20th in the online edition of the worldwide journal Nature Biotechnology.
2013.02.21 View 9917
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Professor Hwang Kyu Young and Professor Yang Dong Yeol Receives Engineer of Korea Award
Emeritus Professor Hwang Kyu Young (Department of Computer Sciences) and Professor Yang Dong Yeol (Department of Mechanical Engineering) were named as the 2012 Engineer of Korea by the Ministry of Education, Science, and Technology and Korea Science Foundation.
The Engineer of Korea Award is awarded biannually to scientists and engineers that have contributed to the development of Korea’s science and technology and national economy.
Professor Hwang’s work with DBMS and close coupling architecture of information search and overall new theories and application technology development in the field of database system has aided the opening and expansion of IT software industry development and the advent of internet information culture era.
Professor Yang is a word renowned scholar in the field of net shape manufacturing and is considered to have opened a new page in the field of nano-molding technique.
In addition, Professor Eum Sang Il (Department of Mathematical Science) has been selected as the 2012 Young Scientist Award.
2013.01.22 View 10221
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KAIST OLEV (On-Line Electric Vehicle) to begin operation!
An On-Line Electric Vehicle (OLEV) that can charge during travel will be put into service for the first time in the world on normal roads.
From July of this year 2 OLEV buses will undergo trial operations in the city of Gumi.
The trial route spans 24km from Gumi station and the region of In-Dong and the establishment of the route is expected to be of a 4.8billion Won scale. The start of the infrastructure construction will start on February and operation will start in July.
KAIST had held sessions in October of last year to local governments and had a follow up OLEV suitability evaluation to those local governments expressing interest.
The city of Gumi was elected due to its good electrical infrastructure and an administrative willingness to match.
The OLEV developed by KAIST is an environmentally friendly vehicle that allows the transfer of electrical power using magnetic fields imbedded in the roads.
Ordinary electric vehicles require frequent visits to replenish their power which gives the OLEV a comparative advantage as it can charge while on the road. The ability to charge whilst on the road means that the OLEV requires a smaller battery than the ordinary electrical vehicle resulting in lower prices and weight.
The OLEV development commenced at KAIST in 2009 and in 2010 most of the core technologies required to realize the OLEV was developed and verified. Finally in 2012 steps were taken that will allow the commercialization of the OLEV.
And in October of last year KAIST OLEV accomplished 75% power transfer efficiency that allowed a system that can be commercialized.
The KAIST OLEV was named top 50 inventions in 2010 by Time Magazine.
2013.01.22 View 10346
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KAIST Professors win 2012 Korea Engineering Award
Distinguished Professor Hwang Gyu Young (Department of Computer Science) and Professor Yang Dong Yol (Department of Mechanical Engineering) from KAIST received the 2012 ‘Korea Engineering Award’ hosted by the Ministry of Education, Science and Technology and the Korea Research Foundation.
The ‘Korea Engineering Award’ is given biennially to researchers who have accomplished world class research and have contributed greatly to Korea’s development in the field of Science and Technology. The award started in 1994 and a total of 24 recipients were recognized in various fields such as electronics, mechanics, chemistry, construction, etc. The recipients of the award areawarded the Presidential award as well as 50million won as prize money.
Professor Hwang was recognized for his research on DBMS close-coupling architecture as well as other new data base system theories, contributing to the development of the IT software industry in Korea. Professor Yang was praised for his work in precision shape creation and manufacturing, especially for his work in the nano-stereolithography process.
In addition, Professor Oum Sang-il from the Deparment of Mathematical Science received the 2012 ‘Young Scientist Award’ hosted by the Ministry of Education, Science and Technology and the Korean Academy of Science and Technology.
The ceremony for ‘Korea Engineering Award’ and the ‘Young Scientist Award’ was held in Seoul Press Center Press Club on the 21st of December.
2012.12.26 View 11721