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Professor Eunjoon Kim Is KAIST's Person of the Year 2014
KAIST announced that it has named Chair Professor Eunjoon Kim of the Department of Biological Sciences as its “Person of the Year 2014.” The award ceremony took place at the auditorium on campus on January 5, 2014.
Established in 2001, the award has been presented to a KAIST faculty member who has made great achievements in research and education, thereby contributing to the advancement of KAIST.
Professor Kim was the first to identify the mechanism of synapse formation between neurons during his post-doctoral program at Harvard Medical School in 1995. The research was published in Nature.
In 2011, Professor Kim discovered that the lack of protein GIT1, a neuronal synapse in the brain, caused ADHD (Attention Deficit Hyperactivity Disorder). He is widely recognized for his work concerning synapse proteins and brain disease related research that set the foundation for future medical developments.
In his award speech, Professor Kim said, “Whenever a research finding concerning a new drug therapy or research is published, I receive many inquiries from the parents of children with ADHD or autism. As a scientist, I would like to focus my research ultimately to help those in pain, rather than just pursuing research excellence or reputation.”
2015.01.06 View 9670 -
A Key Signal Transduction Pathway Switch in Cardiomyocyte Identified
A KAIST research team has identified the fundamental principle in deciding the fate of cardiomyocyte or heart muscle cells. They have determined that it depends on the degree of stimulus in β-adrenergic receptor signal transduction pathway in the cardiomyocyte to control cells' survival or death. The findings, the team hopes, can be used to treat various heart diseases including heart failure.
The research was led by KAIST Department of Bio and Brain Engineering Chair Professor Kwang-Hyun Cho and conducted by Dr. Sung-Young Shin (lead author) and Ph.D. candidates Ho-Sung Lee and Joon-Hyuk Kang. The research was conducted jointly with GIST (Gwangju Institute of Science and Technology) Department of Biological Sciences Professor Do-Han Kim’s team. The research was supported by the Ministry of Science, ICT and Future Planning, Republic of Korea, and the National Research Foundation of Korea. The paper was published in Nature Communications on December 17, 2014 with the title, “The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.”
The β-adrenergic receptor signal transduction pathway can promote cell survival (mediated by β2 receptors), but also can result in cell death by inducing toxin (mediated by β1 receptors) that leads to various heart diseases including heart failure. Past attempts to identify the fundamental principle in the fate determining process of cardiomyocyte based on β-adrenergic receptor signalling concluded without much success.
The β-adrenergic receptor is a type of protein on the cell membrane of cardiomyocyte (heart muscle cell) that when stimulated by neurohormones such as epinephrine or norepinephrine would transduce signals making the cardiomyocyte contract faster and stronger.
The research team used large-scale computer simulation analysis and systems biology to identify ERK* and ICER** signal transduction pathways mediated by a feed-forward circuit as a key molecular switch that decides between cell survival and death.
Weak β-adrenergic receptor stimulations activate ERK signal transduction pathway, increasing Bcl-2*** protein expression to promote cardiomyocyte survival. On the other hand, strong β-adrenergic receptor stimulations activate ICER signal transduction pathway, reducing Bcl-2 protein expression to promote cardiomyocyte death.
Researchers used a systems biology approach to identify the mechanism of B-blocker****, a common drug prescribed for heart failure. When cardiomyocyte is treated with β1 inhibitor, strong stimulation on β-adrenergic receptor increases Bcl-2 expression, improving the chance of cardiomyocyte survival, a cell protection effect.
Professor Kwang-Hyun Cho said, “This research used systems biology, an integrated, convergence research of IT (information technology) and BT (biotechnology), to successfully identify the mechanism in deciding the fate of cardiomyocytes based on the β-adrenergic receptor signal transduction pathway for the first time. I am hopeful that this research will enable the control of cardiomyocyte survival and death to treat various heart diseases including heart failure.”
Professor Cho’s team was the first to pioneer a new field of systems biology, especially concerning the complex signal transduction network involved in diseases. Their research is focused on modelling, analyzing simulations, and experimentally proving signal pathways. Professor Cho has published 140 articles in international journals including Cell, Science, and Nature.
* ERK (Extracellular signal-regulated kinases): Signal transduction molecule involved in cell survival
** ICER (Inducible cAMP early repressor): Signal transduction molecule involved in cell death
*** Bcl-2 (B-cell lymphoma 2): Key signal transduction molecule involved in promotion of cell survival
**** β-blocker: Drug that acts as β-adrenergic receptor inhibitor known to slow the progression of heart failure, hence used most commonly in medicine.
Picture: A schematic diagram for the β-AR signalling network
2015.01.05 View 12113 -
Broadband and Ultrathin Polarization Manipulators Developed
Professor Bumki Min from the Department of Mechanical Engineering at KAIST has developed a technology that can manipulate a polarized light in broadband operation with the use of a metamaterial.
It is expected that this technology will lead to the development of broadband optical devices that can be applied to broadband communication and display.
When an object or its structure is analyzed by using a polarized light such as a laser, the results are generally affected by the polarized state of the light. Therefore, in an optics laboratory, the light is polarized by various methods.
In such cases, researchers employ wave plates or photoactive materials. However, the performance of these devices depend vastly on wavelength, and so they are not suitable to be used as a polarizer, especially in broadband.
There were many attempts to make artificial materials that are very photoactive by using metamaterials which have a strong resonance. Nonetheless, because the materials had an unavoidable dispersion in the resonance frequency, they were not adequate for broadband operation.
Professor Min’s research team arranged and connected helical metamaterials that are smaller than the wavelength of light. They verified theoretically and experimentally that polarized light can be constantly rotated regardless of the wavelength by super-thin materials that have thickness less than one-tenth of the wavelength of the light. The experiment which confirmed the theory was conducted in the microwave band.
Broadband polarized rotational 3D metamaterials were found to rotate the polarized microwave within the range of 0.1 GHz to 40 GHz by 45 degrees regardless of its frequency. This nondispersive property is quite unnatural because it is difficult to find a material that does not change in a wide band.
In addition, the research team materialized the broadband nondispersive polarized rotational property by designing the metamaterial in a way that it has chirality, which determines the number of rotations proportional to the wavelength.
Professor Min said, “As the technology is able to manipulate ultrathin polarization of light in broadband, it will lead to the creation of ultra-shallow broadband optical devices.”
Sponsored by the Ministry of Science, ICT and Future Planning of the Republic of Korea and the National Research Foundation of Korea, this research was led by a PhD candidate, Hyun-Sung Park, under the guidance of Professor Min. The research findings were published online in the November 17th issue of Nature Communications.
Figure 1 – Broadband and Ultrathin Polarization Manipulators Produced by 3D Printer
Figure 2 – Concept of Broadband and Ultrathin Polarization Manipulators
2014.12.03 View 10357 -
Elsevier Selects a KAIST Graduate's Paper as the Top Cited Papers in 2011-2012
Dr. Myung-Won Seo, a graduate from the Department of Chemical and Bimolecular Engineering at KAIST, published a paper in January 2011 in Chemical Engineering Journal, which was entitled “Solid Circulation and Loop-seal Characteristics of a Dual Circulating Fluidized Bed: Experiments and CFD Simulation.” His paper was selected by Elsevier as the Top Cited Papers of 2011-2012. The Chemical Engineering Journal is a renowned peer-reviewed journal issued by Elsevier.
Dr. Seo published another paper, “CFD Simulation with Experiments in a Dual Circulating Fluidized Bed Gasifier,” in January 2012 in Computers & Chemical Engineering, which was also selected as the Most Downloaded Papers in 2012-2013.
Dr. Seo graduated with a doctoral degree from KAIST in 2011. He is currently working at the Clean Fuel Laboratory, the Korea Institute of Energy Research, Daejeon, as a researcher. His research areas are coal gasification, upgrading, and liquefaction, as well as energy and chemical production from low-grade fuels such as biomass and wastes.
2014.11.24 View 8655 -
3D Printer Developed by KAIST Undergraduate Students
More than 100 Pre-orders Prior to Product Launch Made
KAIST undergraduate students received more than 100 pre-orders before the launch for 3D printers they developed and became a hot topic of interest.
KAIST Research Institute for Social Technology and Innovations (Head Hong-Kyu Lee) had a launch party at Daejeon Riviera Hotel on 17 November 2014 for “Commercial Delta 3D Printer” developed by KAIST undergraduate students inviting around 50 businesses, buyers and representatives of 3D Printing Industry Association.
“3D Printer” uses blueprints of products such as toys, mug cups and chairs to make 3D objects and is thought to be revolutionary technology in manufacturing industry. The interest has grown as recent printers could print even fruits and cosmetics.
The printing structure of 3D printer can be divided roughly into horizontal Mendel method and Delta method. KAIST students focused on the Delta method to give a differentiated product from 90% of commercial products that use Mendel method.
First, the students focused on lowering the cost of unit price by using self-developed components. The carriage (transport machine) of the product is replaced by self-developed components instead of bearing to reduce the noise and the linking method was changed to beads from loop guide to increase the completeness of the printed product. Also, an auto-levelling is loaded to ensure the nozzle and the bed is parallel and hence increasing convenience for the users. Further, the printer, designed by a product designer in Germany, is linked to a smartphone application for blueprints.
A student in the development team, Seokhyeon Seo (Department of Computer Science, 3rd Year Undergraduate) said, “The biggest merits of the product are lowering the price to a 1/3 by using self-developed components and reducing the noise.” He continued, “By using a smartphone application, anyone can easily design the product. So it is applicable to use for education or at home”
In the exhibit, “3D Printing Korea 2014,” in Coex, Seoul the printer had a preview demonstration, and received more than 100 pre-orders from educational and business training institutions. Further, buyers from Canada and the US requested opening agencies in their countries.
KAIST Research Institute for Social Technology and Innovations Head Hong-Kyu Lee said, “3D printing is an innovative technology that could bring the 3rd industrial revolution.” He continued, “It is still early days but the demand will increase exponentially.”
This project was a research project of KAIST Research Institute for Social Technology and Innovations led by a development team consisting of 4 undergraduate students of KAIST, one student from University of Oxford and one German product designer.
Students in the picture below are Won-Hoi Kim (Department of Mechanical Engineering), Sung-Hyun Cho (Department of Mechanical Engineering), and Suk-Hyun Seo (Department of Computer Science) from left to right.
2014.11.19 View 9976 -
The Website of the KAIST Industrial Design Department Receives a Design Award
The 10th QS-Apple Higher Education Conference and Exhibition took place on November 11-13, 2014 in Taipei, Taiwan. The conference was hosted by Quacquarelli Symonds, a British company specializing in education, which publishes annually its world university rankings. Apple stands for Asia Pacific Professional Leaders in Education.
The QS-Apple conference supports the internationalization of Asia Pacific universities by providing opportunities for networking, exchanging best practices, and discussing recent developments in higher education. During the conference, the organizers presented the Creative Awards for best international education promotional designs in four categories: Website Pages, Video, Print Advertisement, and International Student Recruitment Brochures.
KAIST’s Industrial Design Department received the Best Website Pages Award for their website in recognition of high levels of user convenience and satisfaction as well as English language services. A total of 39 universities in the Asia and Pacific region competed in this category, and Nanyang Technological University in Singapore came in second place, followed by Hong Kong Baptist University in third.
2014.11.13 View 8008 -
Distinguished Professor Sang Yup Lee Accepts an Honorary Professorship at Beijing University of Chemical Technology
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at KAIST has been appointed an honorary professor at Beijing University of Chemical Technology (BUCT). Founded in 1958, BUCT is one of the outstanding universities in mainland China, especially in chemistry studies.
In addition to the Chinese Academy of Sciences (2012), Shanghai Jiao Tong University (2013), Wuhan University (2014), and Hebei University of Technology (2014), this is the fifth honorary professorship Professor Lee has received from higher education institutions in China.
Professor Lee was recognized for his pioneering research in systems metabolic engineering of microorganisms necessary for the development of green chemical industries. He succeeded in producing succinic acid through bacterial fermentation and engineering plastic raw materials in the most effective and economical method for the first time in the world. Professor Lee also developed polylactic acid, a bio-based polymer that allows plastics to be produced through natural and renewable resources, as well as the microbial production of alkanes, an alternative to gasoline that can be produced from fatty acids.
Professor Lee has been actively working as a member of a group of global leaders supported by the World Economic Forum (WEF), serving as the Chairman of the Future of Chemicals, Advanced Materials & Biotechnology, Global Agenda Councils, WEF.
2014.11.13 View 10344 -
A KAIST Student Team Wins the ACM UIST 2014 Student Innovation Contest
A KAIST team consisted of students from the Departments of Industrial Design and Computer Science participated in the ACM UIST 2014 Student Innovation Contest and received 1st Prize in the category of People’s Choice.
The Association for Computing Machinery (ACM) Symposium on User Interface Software and Technology (UIST) is an international forum to promote innovations in human-computer interfaces, which takes place annually and is sponsored by ACM Special Interest Groups on Computer-Human Interaction (SIGCHI) and Computer Graphics (SIGGRAPH). The ACM UIST conference brings together professionals in the fields of graphical and web-user interfaces, tangible and ubiquitous computing, virtual and augmented reality, multimedia, and input and output devices.
The Student Innovation Contest has been held during the UIST conference since 2009 to innovate new interactions on state-of-the-art hardware. The participating students were given with the hardware platform to build on—this year, it was Kinoma Create, a JavaScript-powered construction kit that allows makers, professional product designers, and web developers to create personal projects, consumer electronics, and "Internet of Things" prototypes. Contestants demonstrated their creations on household interfaces, and two winners in each of three categories -- Most Creative, Most Useful, and the People’s Choice -- were awarded.
Utilizing Kinoma Create, which came with a built-in touchscreen, WiFi, Bluetooth, a front-facing sensor connector, and a 50-pin rear sensor dock, the KAIST team developed a “smart mop,” transforming the irksome task of cleaning into a fun game. The smart mop identifies target dirt and shows its location on the display built in the rod of a mop. If the user turns on a game mode, then winning scores are gained wherever the target dirt is cleaned.
The People’s Choice award was decided by conference attendees, and they voted the smart mop as their most favorite project.
Professor Tek-Jin Nam of the Department of Industrial Design at KAIST, who advised the students, said, "A total of 24 teams from such prestigious universities as Carnegie Mellon University, Georgia Institute of Technology, and the University of Tokyo joined the contest, and we are pleased with the good results. Many people, in fact, praised the integration of creativity and technical excellence our have shown through the smart mop.”
Team KAIST: pictured from right to left, Sun-Jun Kim, Se-Jin Kim, and Han-Jong Kim
The Smart Mop can clean the floor and offer users a fun game.
2014.11.12 View 10081 -
President Steve Kang will serve as the Chairman of Global Agenda Council on the Future of Electronics of the World Economic Forum
President Steve Kang of KAIST has been appointed to the Chairman of the Global Agenda Council (GAC) on the Future of Electronics of the World Economic Forum (WEF). He will serve the position for two years until September 2016.
President Kang and WEF council members co-hosted, with the government of the United Arab Emirates (UAE), the Future Circles Initiative, a future-focused, innovative brainstorming conference to help find strategies and ideas for the development of UAE. The conference took place on November 11-12, 2014 at the Mina Al Salam Hotel in Dubai.
WEF has about 80 GACs. Each council consists of 15 experts and thought leaders from the academia, industry, government, business, and non-profit sector and deals with specific issues that are important and relevant to the global community such as ageing, artificial intelligence and robotics, brain research, food and nutrition security, education, social media, and future of chemicals, advanced materials and biotechnology.
President Kang was recognized for his contribution to the advancement of science and higher education as an engineer, scholar, and professor. He led the development of the world’s premier CMOS 32-bit microprocessors while working at the AT&T Bell Laboratories. He also taught and conducted research at the University of California, Santa Cruz, and the University of Illinois, Urbana-Champaign. President Kang served as the chancellor of the University of California at Merced from March 2007 to June 2011.
2014.11.11 View 8141 -
KAIST Develops Core Technology to Synthesize a Helical Nanostructure
Professor Dong-Ki Yoon’s research team of the Graduate School of Nanoscience and Technology (GSNT) at KAIST has developed helical nanostructures using self-assembly processes. The results were published in the Proceedings of the National Academy of Sciences of the United States of America(PNAS) on the October 7th.
This technology enables the synthesis of various helical structures on a relatively large confined area. Its synthesis is often considered the most arduous for three dimensional structures. Formed from liquid crystal, the structure holds a regular helical structure within the confined space of 20 to 300 nanometers. Also, the distance between each pattern increased as the diameter of the nanostructure increased.
Liquid crystals have a unique property of responding sensitively to the surrounding electromagnetic field. The technology, in combination with the electromagnetic property of liquid crystal, is expected to foster the development of highly efficient optoelectronic devices.
Using this technology, it is possible to develop three dimensional patterning technology beyond the current semiconductor manufacturing technology which uses two dimensional photolithography processes. Three-dimensional semiconductor devices are expected to store hundred times more data than current devices. They will also lower costs by simplifying manufacturing processes.
The essence of this research, “self-assembly in confined space,” refers to controlling complex nanostructures, which can be synthesized from materials such as macromolecules, liquid crystal molecules, and biomolecules in relation to surrounding environments including the temperature, concentration, and pH.
The research team produced a confined space with a length of tens of nanometers by using a porous anodized aluminum membrane induced from an electrochemical reaction. They successfully synthesized independently controlled helical nanostructures by forming the helical structures from liquid crystal molecules within that space.
Professor Yoon said, “This research examines the physicochemical principle of controlling helical nanostructures.” He highlighted the significance of the research and commented, “The technology enables the control of complex nanostructures from organic molecules by using confined space and surface reforming.”
He added that, “When grafted with nanotechnology or information technology, this technology will spur new growth to liquid crystal-related industries such as the LCD.”
The research was led by two Ph.D. candidates, Hanim Kim and Sunhee Lee, under the guidance of Professor Yoon. Dr. Tae-Joo Shin of the Pohang Accelerator Laboratory, Professor Sang-Bok Lee of the University of Maryland, and Professor Noel Clark of the University of Colorado also participated.
Picture 1. Electron Microscopy Pictures and Conceptual Diagrams of Helical Nanostructures
Picture 2. Electron Microscopy Pictures of Manufactured Helical Nanostructures
2014.10.29 View 8190 -
KAIST Registers an Internationally Recognized Standard Patent
A video compression technology, jointly developed by Professor Mun-Chul Kim of the Department of Electrical Engineering at KAIST, the Electronics and Telecommunications Research Institute (ETRI), and the Korean Broadcasting System (KBS), is registered internationally as the standard patent in the next-generation High Efficiency Video Coding (HEVC).
HEVC (H.265) is an international technology standard that compresses large image data for Ultra High Definition (UHD) televisions and smartphones. It has the twice the compression efficiency as that of H.264/AVC which is most commonly used for processing full HD sources. This means that it is able to compress a video file to half the size while maintaining the same image quality.
Although the related market is at a nascent stage, HEVC technology has already been applied to the latest version of televisions and smartphones. Experts predict that the market will grow to USD 200 billion by 2016, and KAIST is expected to receive a royalty payment of USD 9.3 million from this patent.
The International Organization for Standardization (ISO/IEC) established the HEVC standard in January 2013. Also, an international patent pool licensing corporation, MPEG LA announced the HEVC standard patent pool on September 29, 2014.
Professor Joongmyeon Bae, Dean of the Office of University-Industry Cooperation (OUIC) of KAIST, said, “This is an unprecedented case for Korea whereby a core technology developed by a university became an international standard, which has a vast impact on the market.”
President of KAIST, Steve Kang commented, “With its advanced technology, KAIST joined the HEVC standard patent pool as one of the 23 founding members along with Apple, Siemens, and NEC. This is a remarkable achievement.”
Picture 1: Improvements in video compression technology
Picture 2: Comparison of different screen resolutions
2014.10.09 View 11304 -
KAIST Co-owns the HEVC Patent Portfolio License
MPEG LA, LLC, a firm based in Denver, Colorado, which licenses patent pools covering essential patents required for the use of video coding technology, such as MPEG-2, MPEG-4 Visual (Part 2), and HEVC/H.264, announced the availability of the High Efficiency Video Coding (HEVC) Patent Portfolio License on September 29, 2014.
The HEVC standard, also known as H.265 and MPEG-H Part 2, is necessary to improve video coding and transmission efficiency for the Internet, televisions, and mobile gadgets with increased speed and capacity.
Through the portfolio license, users can easily obtain patent rights required for the HEVC standard in a single transaction, instead of negotiating separate licenses from multiple patent holders.
A total of 23 enterprises currently own essential HEVC patents. KAIST is the only Korean university among the joint patent owners. Collaborating with the Korea Broadcasting System (KBS) and the Electronics and Telecommunications Research Institute (ETRI), Professor Mun-Chul Kim of the Electrical Engineering Department at KAIST developed one of the core patents.
For a link to a press release distributed by MPEG LA, LLC, please see:
MPEG LA, LLC, September 29, 2014
"MPEG LA, LLC Offers HEVC Patent Portfolio License"
http://www.mpegla.com/main/Pages/Media.aspx
2014.10.02 View 11316