Engineering
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Optimal Immuno-Therapeutic Strategies for Liver Cancer
KAIST medical scientists have presented a heterogeneity of immune cell exhaustion in the cancer environment, providing evidence and rationale for designing optimal strategies for immune checkpoint inhibitors in liver cancer patients.
They succeeded in distinguishing the hepatocellular carcinoma group from the exhausted tumor infiltrating immune cell composition of liver cancer patients. The study, conducted in collaboration with Asan Medical Center, confirmed the applicability for liver cancer patients, providing a new path for personalized precision medicine as well as a new model for translational research.
Our immune system is able to destroy cancerous cells in our body, however sometimes cancer cells can adapt and mutate, effectively hiding from our immune system. One of the mechanisms that has evolved to prevent eradication by the immune system is to functionally silence effector T cells, termed T-cell exhaustion, that is mainly mediated by immune checkpoint molecules such as PD-1, TIM-3, and LAG-3.
Recent breakthroughs and encouraging clinical results with various immune checkpoint inhibitors (ICIs), such as anti-PD-1 monoclonal antibodies (mAbs) and anti-CTLA-4 mAbs, have demonstrated tremendous potential to cure cancers through the immune activation of exhausted T cells. Immune checkpoint inhibitors showed significant clinical benefits for several types of cancers, leading to their wide application in clinical practice.
Anti-PD1 blocking antibodies are one of the most representative agents in this class of drug. However, it has been challenging to precisely understand the biological and clinical significance of T-cell exhaustion in cancer. A KAIST research team led by Professor Su-Hyung Park reported the heterogeneity of T-cell exhaustion in hepatocellular carcinoma (HCC) and its potential clinical implications in Gastroenterology on December 4.
The team revealed that heterogeneous T-cell exhaustion status is determined by the differential PD-1 expression levels in CD8+ T cells in liver cancer patients. The authors found that tumor-infiltrating CD8+ T cells with high PD-1 expression from liver cancer patients are functionally impaired and co-express other immune checkpoint receptors such as TIM-3 and/or LAG3, compared to those with low PD-1 expression.
Moreover, based on these results, the authors suggested that liver cancer patients can be classified into two distinct subgroups. Patients having high PD-1 expression levels in the tumor microenvironment showed more aggressive tumor features and biomarkers predicting a favorable response to anti-PD1 therapy. The research team also demonstrated that only liver cancer patients having high PD-1 expression are susceptible to combined immune checkpoint blockade-based therapies.
Prof. Park said, “The new classification of liver cancer patients identified by this study can be utilized as a biomarker to predict the response of current cancer immunotherapy targeting the PD-1 pathway.” He also said they will continue to conduct research on T-cell exhaustion and activation in various types of cancer, which could lead to a better understanding of T-cell response against cancer, thereby providing evidence for future cancer immunotherapy to achieve the ultimate goal to prolong the survival of cancer patients.
2018.12.18 View 4514 -
Characteristics of Submesoscale Geophysical Turbulence Reported
A KAIST research team has reported some of unique characteristics and driving forces behind submesoscale geophysical turbulence. Using big data analysis on ocean surface currents and chlorophyll concentrations observed using coastal radars and satellites has brought better understanding of oceanic processes in space and time scales of O(1) kilometer and O(1) hour. The outcomes of this work will lead to improved tracking of water-borne materials and performance in global and regional climate prediction models.
In 2012, United States National Aeronautics and Space Administration (NASA) released a movie clip called “Perpetual Oceans”, which visualized ocean circulation obtained from satellite altimeter-derived sea surface height observations over two and a half years. When the movie was released to the public, it received a great deal of attention because the circulation patterns were strikingly similar to “The Starry Night” by Vincent van Gogh.
“Perpetual Oceans” is full of vortical flow patterns describing the oceanic turbulent motions at mesoscale (a scale of 100 km or larger). Meanwhile, Professor Sung Yong Kim from the Department of Mechanical Engineering and his team focused on the study of the oceanic turbulence at sub-mesoscale (space and time scales of 1 to 100 km and hours).
Sub-mesoscale processes are important because they contribute to the vertical transport of oceanic tracers, mass, buoyancy, and nutrients and rectify both the mixed layer structure and upper ocean stratification. These process studies have been primarily based on numerical simulations because traditional in situ ocean measurements can be limited in their capability to resolve the detailed horizontal and vertical structures of these processes.
The team conducted big data analysis on hourly observations of one-year ocean surface current maps and five-year chlorophyll concentration maps, obtained from remote sensing instruments such as coastal high-frequency radars (HFRs) and geostationary ocean color imagery (GOCI) to examine the unique characteristics of oceanic submesoscale processes.
The team analyzed the slope change of the wavenumber energy spectra of the observations in terms of season and sampling directions. Through the analysis, the team proved that energy cascade (a phenomenon in which large-scale energy transfers to small-scale energy or vice-versa during the turbulent energy transit) occurs in the spatial scale of 10 km in the forward and inverse directions. This is driven by baroclinic instability as opposed to the mesoscale eddy-driven frontogenesis at the O(100) km scale based on the observed regional submesoscale circulations.
This work will contribute to the parameterization of physical phenomenon of sub-mesoscale in the field of global high-resolution modeling within ocean physics and atmospheric as well as climate change. Based on the understanding of the principle of sub-mesoscale surface circulation, practical applications can be further derived for radioactivity, oil spill recovery, and marine pollutant tracking.
Moreover, the data used in this research was based on long-term observations on sub-mesoscale surface currents and concentrations of chlorophyll, which may reflect the submesoscale processes actively generated in the subpolar front off the east coast of Korea. Hence, this study can potentially be beneficial for integrated big data analyses using high-resolution coastal radar-derived surface currents and satellite-derived products and motivate interdisciplinary research between ocean physics and biology.
This research was published as two companion papers in the Journal of Geophysical Research: Oceans on August 6, 2018. (doi:10.1002/2016JC012517; doi:10.1002/2017JC013732)
Figure 1.'The Starry Night' of Van Gogh and the 'Perpetual Ocean' created by NASA's Goddard Space Flight Center.
Figure 2. A schematic diagram of the energy cascades in forward and backward directions and the spatial scale where the energy is injected.
Figure 3. A snapshot of the chlorophyll concentration map derived from geostationary ocean color imagery (GOCI) off the east coast of Korea presenting several examples of sub-mesoscale turbulent flows.
Figure 4. Energy spectra of the HFR-derived surface currents and GOCI-derived chlorophyll concentrations and the temporal variability of spectral decay slopes in the cross-shore and along-shore directions.
2018.12.13 View 4835 -
Reducing the Drag Force of a Moving Body Underwater
(from left: Professor Yeunwoo Cho and PhD Jaeho Chung)
Professor Yeunwoo Cho and his team from the Department of Mechanical Engineering developed new technology that reduces the drag force of a moving body in a still fluid by using the supercavitation phenomenon.
When a body moves in air, the frictional drag is lower than that of the same body moving in water. Therefore, the body that moves in water can reduce the drag significantly when it is completely enveloped in a gaseous cavity.
The team used compressed air to create so-called supercavitation, which is a phenomenon created by completely enveloping a body in a single large gaseous cavity. The drag force exerted on the body is then measured.
As a result, the team confirmed that the drag force for a moving body enveloped in air is about 25% of the drag force for a moving body without envelopment.
These results can be applied for developing high-speed underwater vehicles and the development of air-lubricated, high-speed vessels.
The team expects that the results can be applied for developing high-speed underwater vehicles and the development of air lubrication for a ship’s hull.
This research, led by PhD Jaeho Chung, was published in the Journal of Fluid Mechanics as a cover article on November 10, 2018.
Figure 1. The cover article of the Journal of Fluid Mechanics Vol. 854
2018.12.04 View 3738 -
From Concept to Reality: Changing Color of Light Using a Spatiotemporal Boundary
(from left: Professor Bumki Min, PhD candidate Jaehyeon Son and PhD Kanghee Lee)
A KAIST team developed an optical technique to change the color (frequency) of light using a spatiotemporal boundary. The research focuses on realizing a spatiotemporal boundary with a much higher degree of freedom than the results of previous studies by fabricating a thin metal structure on a semiconductor surface. Such a spatiotemporal boundary is expected to be applicable to an ultra-thin film type optical device capable of changing the color of light.
The optical frequency conversion device plays a key role in precision measurement and communication technology, and the device has been developed mainly based on optical nonlinearity.
If the intensity of light is very strong, the optical medium responds nonlinearly so the nonlinear optical phenomena, such as frequency doubling or frequency mixing, can be observed. Such optical nonlinear phenomena are realized usually by the interaction between a high-intensity laser and a nonlinear medium.
As an alternative method frequency conversion is observed by temporally modifying the optical properties of the medium through which light travels using an external stimulus. Since frequency conversion in this way can be observed even in weak light, such a technique could be particularly useful in communication technology.
However, rapid optical property modification of the medium by an external stimulus and subsequent light frequency conversion techniques have been researched only in the pertubative regime, and it has been difficult to realize these theoretical results in practical applications.
To realize such a conceptual idea, Professor Bumki Min from the Department of Mechanical Engineering and his team collaborated with Professor Wonju Jeon from the Department of Mechanical Engineering and Professor Fabian Rotermund from the Department of Physics. They developed an artificial optical material (metamaterial) by arranging a metal microstructure that mimics an atomic structure and succeeded in creating a spatiotemporal boundary by changing the optical property of the artificial material abruptly.
While previous studies only slightly modified the refractive index of the medium, this study provided a spatiotemporal boundary as a platform for freely designing and changing the spectral properties of the medium. Using this, the research team developed a device that can control the frequency of light to a large degree.
The research team said a spatiotemporal boundary, which was only conceptually considered in previous research and realized in the pertubative regime, was developed as a step that can be realized and applied.
Professor Min said, “The frequency conversion of light becomes designable and predictable, so our research could be applied in many optical applications. This research will present a new direction for time-variant media research projects in the field of optics.”
This research, led by PhD Kanghee Lee and PhD candidate Jaehyeon Son, was published online in Nature Photonics on October 8, 2018.
This work was supported by the National Research Foundation of Korea (NRF) through the government of Korea. The work was also supported by the Center for Advanced Meta-Materials (CAMM) funded by the Korea Government (MSIP) as the Global Frontier Project (NRF-2014M3A6B3063709).
Figure 1. The frequency conversion process of light using a spatiotemporal boundary.
Figure 2. The complex amplitude of light at the converted frequency with the variation of a spatiotemporal boundary.
2018.11.29 View 6929 -
KAIST Shows Strong Performance in Crypto Contest Korea 2018
(Awardees at the ceremony for Crypto Contest Korea 2018)
A paper titled “Indifferentiability of Truncated Random Permutations” by PhD candidate Wonseok Choi and MS candidate Byeonghak Lee (under Professor Jooyoung Lee) from the KAIST Graduate School of Information Security (GSIS) won first place in Crypto Contest Korea 2018. Byeonghak Lee became a repeat winner since his paper titled “Tweakable Block Ciphers Secure Beyond the Birthday Bound in the Ideal Cipher Model” also received an award at Crypto Contest Korea 2017.
The contest, hosted by the Korea Cryptography Forum, the Korea Institute of Information Security & Cryptology, and the National Security Research Institute and sponsored by the National Intelligence Service, was held for promoting cryptography in Korea. The total prize money is fifty million won with ten million won going to the first place winners.
The contest was divided into three divisions: paper, problem solving, and idea. Among the three divisions, first place came from the paper division only.
Besides first place, KAIST students showed outstanding performance in the contest. PhD candidate Seongkwang Kim received participation prize while he also received special prizes with MS candidate Yeongmin Lee. The hacking club GoN (under Professor Sang Kil Cha), comprised of undergraduate students from the GSIS was awarded the grand prize in the division of problem solving.
The award ceremony was held during the Future Crypto Workshop 2018 on November 15. The awards ceremony for Crypto Expert Korea 2018 were also held there, and PhD candidate Ji-Eun Lee from the School of Computing and Byeonghak Lee received awards, the grand prize and runner-up prize respectively.
2018.11.27 View 6718 -
Silk Adhesive Paves the Way for Epidermal Electronics
(from left: Dr. Ji-Won Seo, Professor Hyunjoo Jenny Lee and PhD candidate, Hyojung Kim)
Producing effective epidermal electronics requires a strong, biocompatible interface between a biological surface and a sensor. Here, a KAIST team employed a calcium-modified silk fibroin as a biocompatible and strong adhesive. This technology led to the development of epidermal electronics with strong adhesion for patients who need drug injections and physiological monitoring over a long time.
Recently, biocompatible silk fibroins has been increasingly used for flexible substrates and water-soluble sacrificial layers because they allow structural modifications and are biodegradable. From previous studies, the team discovered the adhesive properties of silk fibroin via metal chelate bonding and the water-capturing of Ca ions.
Professor Hyunjoo Jenny Lee from the School of Electrical Engineering and her team explored ways to develop reusable, water-degradable, biocompatible and conductive epidermal electronics that can be attached to the human skin for long-term use. To overcome the limitations of conventional silk fibroin, the team introduced Ca ions to modify silk fibroin into a strong and biocompatible adhesive.
Calcium ions adopted in silk fibroins serve to capture water and enhance the cohesion force through metal chelation. Therefore, this endows viscoelasticity to previously a firm silk fibroin. This modified silk fibroin exhibits strong viscoelasticity and strong adhesiveness when physically attached to the human skin and various polymer substrates. Their developed silk adhesive is reusable, water-degradable, biocompatible, and conductive.
To test the effectiveness, the team employed the silk adhesive to fabricate an epidermal capacitive touch sensor that can be attached to the human skin. They verified the reusability of the sensor by performing attachment and detachment tests. They also confirmed that the physical adhesion of the Ca-modified silk facilitates its reusability and possesses high peel strength.
Furthermore, they tested the stretchability of the silk adhesive on bladder tissue. Although it is not an epidermal skin, bladder tissue is highly stretchable. Hence, it is a perfect target to measure the resistance-strain characteristic of the silk adhesive. When the bladder tissue was stretched, the resistive strain epidermal sensor corresponded to the tensile strain.
Showing high biocompatibility, the silk adhesive is suitable for interfacing with the human skin for a long period of time. Therefore, it can also be applied to a drug delivery epidermal system as well as an electrocardiogram (ECG) epidermal sensor.
Professor Lee said, “We are opening up a novel use for silk by developing reusable and biodegradable silk adhesive using biocompatible silk fibroin. This technology will contribute to the development of next-generation epidermal electronics as well as drug delivery systems.
This research, led by Dr. Ji-Won Seo and a PhD candidate, Hyojung Kim, was published in Advanced Functional Materials on September 5, 2018.
Figure 1. Schematic and photograph of a hydrogel patch adhered on the human skin through the silk adhesive
Figure 2. Cover page of Advanced Functional Materials
2018.11.21 View 5810 -
Distinguished Professor Lee Re-Appointed As Co-Chair of the Global Future Council on Biotechnology
(Distinguished Professor Sang Yup Lee)
Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering was re-appointed as the co-chair of the Global Future Council on Biotechnology at the World Economic Forum during the annual GFC meeting in Dubai, UAE last week. Elizabeth O’Day, founder and CEO of Olaris Therapeutics, will co-chair the council with him for two years.
Professor Lee served as the inaugural co-chair of the council for two years from 2016 with Professor Feng Zhang from the Broad Institute of MIT and Harvard.
The World Economic Forum’s Global Future Councils on Biotechnology is comprised of 14 members and aims to identify policy opportunities to help accelerate new biotechnological discoveries and applications while guiding dialogue with consumers about their implications.
Professor Lee, who has made significant research breakthroughs in the field of systems metabolic engineering, received the George Washington Carver Award, the PV Danckwerts Memorial Lecture Award, and the Eni Award this year.
2018.11.19 View 3215 -
New Anisotropic Conductive Film for Ultra-Fine Pitch Assembly Applications
(Professor Paik(right) and PhD Candidate Yoon)
Higher resolution display electronic devices increasingly needs ultra-fine pitch assemblies. On that account, display driver interconnection technology has become a major challenge for upscaling display electronics.
Researchers have moved to one step closer to realizing ultra-fine resolution for displays with a novel thermoplastic anchoring polymer layer structure. This new structure can significantly improve the ultra-fine pitch interconnection by effectively suppressing the movement of conductive particles. This film is expected to be applied to various mobile devices, large-sized OLED panels, and VR, among others.
A research team under Professor Kyung-Wook Paik in the Department of Materials developed an anchoring polymer layer structure that can effectively suppress the movement of conductive particles during the bonding process of the anisotropic conductive films (ACFs). The new structure will significantly improve the conductive particle capture rate, addressing electrical short problems in the ultra-fine pitch assembly process.
During the ultra-fine pitch bonding process, the conductive particles of conventional ACFs agglomerate between bumps and cause electrical short circuits. To overcome the electrical shortage problem caused by the free movement of conductive particles, higher tensile strength anchoring polymer layers incorporated with conductive particles were introduced into the ACFs to effectively prevent conductive particle movement.
The team used nylon to produce a single layer film with well-distributed and incorporated conductive particles. The higher tensile strength of nylon completely suppressed the movement of conductive particles, raising the capture rate of conductive particles from 33% of the conventional ACFs to 90%. The nylon films showed no short circuit problem during the Chip on Glass assembly. Even more, they obtained excellent electrical conductivity, high reliability, and low cost ACFs during the ultra-fine pitch applications.
Professor Paik believes this new type of ACFs can further be applied not only to VR, 4K and 8K UHD display products, but also to large-size OLED panels and mobile devices.
His team completed a prototype of the film supported by the ‘H&S High-Tech,’ a domestic company and the ‘Innopolis Foundation.’ The study, whose first author is PhD candidate Dal-Jin Yoon, is described in the October issue of IEEE TCPMT.
Figure 1: Schematic process of APL structure fabrication.
Figure 2: Proto-type production of APL ACFs.
2018.11.13 View 5712 -
Team KAT Wins the Autonomous Car Challenge
(Team KAT receiving the Presidential Award)
A KAIST team won the 2018 International Autonomous Car Challenge for University Students held in Daegu on November 2.
Professor Seung-Hyun Kong from the ChoChunShik Graduate School of Green Transportation and his team participated in this contest with the team named KAT (KAIST Autonomous Technologies). The team received the Presidential Award with a fifty million won cash prize and an opportunity for a field trip abroad.
The competition was conducted on actual roads with Connected Autonomous Vehicles (CAV), which incorporate autonomous driving technologies and vehicle-to-everything (V2X) communication system.
In this contest, the autonomous vehicles were given a mission to pick up passengers or parcels. Through the V2X communication, the contest gave current location of the passengers or parcels, their destination, and service profitability according to distance and level of service difficulty.
The participating vehicles had to be equipped very accurate and robust navigation system since they had to drive on narrow roads as well as go through tunnels where GPS was not available. Moreover, they had to use camera-based recognition technology that was invulnerable to backlight as the contest was in the late afternoon.
The contest scored the mission in the following way: the vehicles get points if they pick up passengers and safely drop them off at their destination; on the other hand, points are deducted when they violate lanes or traffic lights. It will be a major black mark if a participant sitting in the driver’s seat needs to get involved in driving due to a technical issue.
Youngbo Shim of KAT said, “We believe that we got major points for technical superiority in autonomous driving and our algorithm for passenger selection.”
This contest, hosted by Ministry of Trade, Industry and Energy, was the first international competition for autonomous driving on actual roads. A total of nine teams participated in the final contest, four domestic teams and five teams allied with overseas universities such as Tsinghua University, Waseda University, and Nanyang Technological University.
Professor Kong said, “There is still a long way to go for fully autonomous vehicles that drive flexibly under congested traffic conditions. However, we will continue to our research in order to achieve high-quality autonomous driving technology.”
(Team KAT getting ready for the challenge)
2018.11.06 View 9501 -
Controlling Crystal Size of Organic Semiconductors
A KAIST research team led by Professor Steve Park from the Department of Materials Science and Engineering
Recently, solution-processable organic semiconductors are being highlighted for their potential application in printed electronics, becoming a feasible technique to fabricate large-area flexible thin film at a low cost. The field-effect mobility of small-molecule organic semiconductors is dependent on the crystallinity, crystal orientation, and crystal size. A variety of solution-based coating techniques, such as ink-jet printing, dip-coating, and solution shearing have been developed to control the crystallinity and crystal orientation, but a method for developing techniques to increase the crystal size of organic semiconductors is still needed.
To overcome this issue, the research team developed an inorganic polymer micropillar-based solution shearing system to increase the crystal size of an organic semiconductor with pillar size. Using this technique, the crystallization process of organic semiconductors can be controlled precisely, and therefore large-area organic semiconductor thin film with controlled crystallinity can be fabricated.
A variety of solution-based coating techniques cannot control the fluid-flow of solutions appropriately, so the solvent evaporates randomly onto the substrate, which has difficulty in the fabrication of organic semiconductor thin film with a large crystal size.
The research team integrated inorganic polymer microstructures into the solution shearing blade to solve this issue. The inorganic polymer can easily be microstructured via conventional molding techniques, has high mechanical durability, and organic solvent resistance. Using the inorganic polymer-based microstructure blade, the research team controlled the size of small molecule organic semiconductors by tuning the shape and dimensions of the microstructure. The microstructures in the blade induce the sharp curvature regions in the meniscus line that formed between the shearing blade and the substrate, and therefore nucleation and crystal growth can be regulated. Hence, the research team fabricated organic semiconductor thin-film with large crystals, which increases the field-effect mobility.
The research team also demonstrated a solution shearing process on a curved surface by using a flexible inorganic polymer-based shearing blade, which expands the applicability of solution shearing.
Professor Park said, “Our new solution shearing system can control the crystallization process precisely during solvent evaporation.” He added, “This technique adds another key parameter that can be utilized to tune the property of thin films and opens up a wide variety of new applications.
The results of this work entitled “Inorganic Polymer Micropillar-Based Solution Shearing of Large-Area Organic Semiconductor Thin Films with Pillar-Size-Dependent Crystal Size” was published in the July 2018 issue of Advanced Materials as a cover article.
2018.10.30 View 5329 -
KAIST Launches Woorisae II
Professor Sejin Kwon from the Department of Aerospace Engineering and his team succeeded in launching a science rocket, named ‘Woorisae II’ at Saemanguem reclamation. This rocket was developed in collaboration with the Satellite Technology Research Lab (SaRTec).
The test-firing was conducted at 10:43 am on Sunday October 28, 2018 (35°N 42’ 06” 126°E 33’ 36”, Radius of 0.6NM). This launch was the follow-up to the previous launch that was cancelled due to not gaining approval for using the airspace.
Professor Kwon’s team put a great deal of effort into securing the land for the rocket launch. As a result, they got approval from the Saemangeum Development and Investment Agency for the land and the Ministry of Land, Infrastructure and Transport for the use of the airspace. The Republic of Korea Air Force and United States Air Force also approved the use of the airspace for the launch of the science rocket for research purposes.
Woorisae II is 2.2 meters long with a diameter of 20cm, and weighs 13kg without a payload. The rocket is powered by a hybrid rocket with hydrogen peroxide oxidizer producing 100 kg of force. The Woorisae II sounding rocket was designed to burn for five seconds and then continue inertial flight for 20 seconds. The target altitude of Woorisae II was set at 3,300 feet to comply with the airspace approval.
The team developed the core components, including a hybrid rocket propulsion system, flight computer and parachute recovery system, as well as a ground control station. The flight data was transmitted to the ground station and recorded to onboard computer memory.
When a malfunction occurs during the flight, Woorisae II was designed to terminate the power flight for safety by shutting the propellant valve and deploying the recovery parachute. All the rocket subsystems and components were developed and supplied by domestic startup companies such as INOCOM and NARA SPACE TEHCNOLOGY.
Generally, sounding rockets reach an altitude beyond 30km and are widely used for testing rocket engines and reentry materials as well as for conducting microgravity experiments. Instruments for atmospheric science can also be installed to measure fine dust and high altitude atmosphere. Besides these science and technology purposes, most advanced spacefaring countries have sounding rocket programs to train and educate young people in the field of space science.
Professor Kwon said, “We will plan to launch upgraded rockets on November 4 and December 6 because we already received approval from the related agencies for using this land and airspace. Based on the experiment, we are planning to develop a cost-efficient small launch vehicle that is capable of delivering a cube satellite into Earth’s orbit.”
(Photos of preparing the rocket launch)
2018.10.29 View 8271 -
Lens-free OLEDs with Efficiency comparable to that of Inorganic LEDs
(from left: Professor Seunghyup Yoo and PhD candidate Jinouk Song)
The use of organic light-emitting diodes (OLEDs) has extended to various applications, but their efficiency is still lagging behind inorganic light-emitting diodes. In this research, a KAIST team provided a systematic way to yield OLEDs with an external quantum efficiency (EQE) greater than 50% with an external scattering medium.
Having properties suitable for thin and flexible devices, OLEDs are popular light sources for displays, such as mobile devices and high quality TVs. In recent years, numerous efforts have been made to apply OLEDs in lighting as well as light sources for vehicles.
For such applications, high efficiency is of the upmost importance for the successful deployment of light sources. Thanks to continuous research and the development of OLEDs, their efficiency is steadily on the rise, and a level equivalent to inorganic LEDs has been demonstrated in some reports.
However, these highly efficient OLEDs were often achieved with a macroscopic lens or complex internal nanostructures, which undermines the key advantages of OLEDs as an affordable planar light sources and tends to hinder their stable operation, thus putting a limitation to their commercialization.
Among various methods proven effective for OLED light extraction, a team led by Professor Seunghyup Yoo at the School of Electrical Engineering focused on the external scattering-based approach, as it can maintain planar geometry and compatibility with flexibility. It is also able to be fabricated on a large scale at a low cost and causes no interference with electrical properties of OLEDs.
Conventionally, research on enhancing OLED light extraction using light scattering has been conducted empirically in many cases. This time, the team developed comprehensive and analytical methodology to theoretically predict structures that maximize efficiency.
Considering OLEDs with the external scattering layers as a whole rather than two separate entities, the researchers combined the mathematical description of the scattering phenomena with the optical model for light emission within an OLED to rapidly predict the characteristics of many devices with various structures. Based on this approach, the team theoretically predicted the optimal combination of scattering layers and OLED architectures that can lead to the maximum efficiency.
Following this theoretical prediction, the team experimentally produced the optimal light scattering film and incorporated it to OLEDs with orange emitters having a high degree of horizontal dipole orientation. As a result, the team successfully realized OLEDs exhibiting EQE of 56% and power efficiency of 221 lm/W. This is one of the highest efficiencies ever realized for an OLED unit device without the help of a macroscopic lens or internal light extraction structures.
Professor Yoo said, “There are various technologies developed for improving OLED light extraction efficiency; nevertheless, most of them have not reached a level of practical use. This research mainly provides a systematic way to attain an EQE of 50% or higher in OLEDs while keeping in mind the constraints for commercialization. The approach shown here can readily be applied to lighting devices or sensors of wearable devices.”.
This research, co-led by Professor Jang-Joo Kim from Seoul National University and Professor Yun-Hi Kim from Gyeongsang National University, was published in Nature Communications on August 10, 2018. (J. Song et al. Nature Communications, 9, 3207. DOI: 10.1038/s41467-018-05671-x)
Figure 1.Photographs of OLEDs with SiO₂ -embedded scattering layers according to scatterance
2018.10.26 View 7580