Medicine
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Genetic Cause of ADHD (Attention Deficit Hyperactivity Disorder) Found
The cooperative research team consisting research teams under Professor Kim Eun Joon and Professor Kang Chang Won of the department of Biological Sciences discovered that ADHD arises from the deficiency of GIT1 protein in the brain’s neural synapses.
ADHD (Attention Deficit Hyperactivity Disorder) is found in around 5% of children around the world and is a disorder where the child becomes unable to concentrate, show over the top responses, and display impulsive behavior.
The research team found that the difference between children with ADHD and those without it is one base in the GIT1 gene. The difference of a single base causes the underproduction of this protein, and those children with low levels of the protein had a higher probability to develop ADHD.
In addition, further evidence was provided when the research team conducted mice experiments. Those mice with low levels of GIT1 exhibited impulsive and exaggerated reactions like humans with ADHD, had learning disabilities, and produced abnormal brain waves. And upon injecting these mice with cure for ADHD, the symptoms of ADHD disappeared.
The impulsive behavior of ADHD children disappears as the child enters adulthood and a similar pattern was found in mice. A mice with low levels of GIT1 showed impulsive behaviors when 2 months old, but these behaviors disappeared as it got older to around 7 months old (equivalent to 20~30 years old for humans).
Professor Kim Eun Joon commented that there has to be equilibrium between mechanisms that excite the neurons and mechanisms that calm the neurons, but the lack of GIT1 leads to the decrease in the mechanisms that calm the neurons which causes the impulsive behavior of ADHD patients.
In addition, Professor Kang Chang Won commented that the results of the experiment has been receiving rave reviews and is being seen as the new method in the production of the cure for ADHD.
The result of the experiment was published in the online edition of Nature Medicine magazine.
2011.04.30 View 10152 -
The Irish Times: Gene link identified in ADHD, April 18, 2011
The Irish Times wrote an article on the recent research breakthrough made by a KAIST research team to identify a gene that triggers the syndrome of Attention Deficit Hyperactivity Disorder (ADHD) among children. Given the heightened attention to the syndrome across the world, the research result has received a great deal of attention not only from the academia but also from the media and public.
For the article, please visit http://www.irishtimes.com/newspaper/ireland/2011/0418/1224294910305.html. The research paper was appeared online April 17, 2011 in Nature Medicine, which will be printed in its May 2011 issue. For the paper, please click the link of http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2330.html.
2011.04.18 View 9286
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Late Dr. Ryu Geun Chul's Achievements and Generous Contributions
First Doctor in the field of Korean Traditional Medicine
The late Dr. Ryu was born in 1926 and is the father figure of Korea’s Traditional Medicine and is its First Doctor (1976 Kyung Hee University), and was the vice-professor of Kyung Hee University of Medicine, Vice-Director of Kyung Hee Institute of Korean Traditional Medicine, and was the first chairman of the Association of Korea Oriental Medicine. He developed the painless acupuncture administering device for the first time in Korea in 1962, and succeeded in anesthetizing a patient for cesarean procedure using acupuncture in 1972.
He even was the first to receive a medical engineering doctorate degree from the Moscow National Engineering School in April of 1996 and developed a stroke rehabilitation machine.
Korea’s Most Generous Donor
Dr. Ryu surprised the world by donating 57.8billion Won worth of real estate to KAIST in August of 2008. Dr. Ryu revealed that his reason for donating such a huge sum to KAIST was due to its focused students giving him the belief that the future of Korea is at KAIST and that the development of science and technology is necessary for Korea to develop into a world class nation and KAIST is the institute most suitable to lead Korea in the field.
Dr. Ryu lived on KAIST campus after donating his entire fortune and even established ‘KAIST scholars and spacemen health research center’ and ‘Dr. Ryu Health Clinic’ as he also wanted to donate his knowledge.
Even when he was a professor at Moscow National Engineering University in the late 1990s he carried out free medical work throughout Korea and in recognition of his devoted work, he was named honorary citizen from Chun Ahn city, San Chung city, and DaeJeon city. In 2007 he donated 450million Won to Cheon Dong Elementary School in Chun Ahn city to build a gymnasium and an indoor golf practice range.
Role as Science and Technology Public Relations Officer
Dr. Ryu volunteered to numerous lectures and interviews after donation to advertise science and technology. His belief that the development of science and technology is necessary for Korea’s development was the driving force behind his efforts at increasing interest and support for the field of science and technology.
In addition, through interviews with MBC, KBS, SBS, KTV, Joong Ang Newspapers, Dong Ah Newspaper and other media mediums, Dr. Ryu improved the public perception on donations whilst increasing the pride of scientists and researchers by highlighting their importance and the importance of science and technology.
In recognition of Dr. Ryu’s efforts, he received the 43rd Science Day Science and Technology Creation Award, 2010 MBC Social Service Special Award, and 2010 ‘Proud Chung Cheong Citizen’ Award.
2011.03.22 View 15520
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Graduate School of Medical Sciences sign Exchange Agreement with Yonsei Graduate School of Medicine
KAIST’s Graduate School of Medical Sciences signed on the 22nd of February an Exchange Agreement with the Yonsei Graduate School of Medicine.
The Agreement was signed with hopes of cooperation in research in the field of medical science and will establish a Cooperation Committee. The committee will put in motion cooperative research, training programs, exchange students, exchange of technology, and hold symposiums and seminars.
The representatives stated that the agreement is more than just a symbolic, ceremonial agreement. The agreement was made so that both graduate schools will develop into a world-class research institute in medical sciences.
2011.03.02 View 9327
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KAIST Wins First Prize at Recon Challenge of Int"l Magnetic Resonance Society
Professor Jong-chul Ye of the Department of Bio and Brain Engineering and Hong Jeong, a doctorate student, won the first prize at the Recon Challenge held as part of a workshop sponsored by the International Society for Magnetic Resonance in Medicine (ISMRM) held in Sedona, the United States.
The workshop took place under the theme of “data sampling and image reconstruction” on Jan. 25-28 in Sedona, Arizona, the United States. The KAIST team beat out major magnetic resonance imaging groups from the U.S. and Europe.
The Recon Challenge is a biennial competition highlighting different reconstruction strategies and metrics to compare them. ISMRM is an international, nonprofit, scientific association which promotes communication, research, development, and applications in the field of magnetic resonance in medicine and biology and other related topics.
At the competition, the KAIST team presented a new dynamic MRI algorithm called k-t FOCUSS that is optimal from a compressed sensing perspective. The main contribution of the method is extension of k-t FOCUSS to a more general framework with prediction and residual encoding. The prediction provides an initial estimate while the residual encoding takes care of the remaining residual signals.
2009.02.06 View 13039 -
KAIST, KRIBB Agree to Cooperate in Research of Convergence Technologies
Oct. 15, 2008 -- KAIST and Korea Research Institute of Bioscience and Biotechnology (KRIBB) have agreed to cooperate in the research of convergence fields of biotechnology, information technology and nanotechnology.
To this end, the two institutions concluded a memorandum of understanding to create a new academia-institute cooperative model in the convergence fields on Oct. 15 in Seoul, with KAIST President Nam-Pyo Suh, KRIBB Director Young-Hoon Park and Vice Minister of Education, Science and Technology Jong-Koo Park in attendance.
Under the agreement, the two institutions will set up the tentatively-named KAIST-KRIBB BINT Convergence Institute for the development of technologies and nurturing skilled manpower in the convergence fields.
The partnership of the two institutions is expected to bring broad-based cooperation opportunities and create a massive synergy effect by combining their resources and infrastructure for the development of convergence technologies, KAIST officials said..
The proposed institute is also designed to build a world-class research hub in systems biotechnology by combining strengths of the two institutions with initiatives to achieve the Korean government"s new vision for "low carbon, green growth."
The institute will also serve as a base for domestic brain convergence by concentrating the nation"s research capacities in genetics and brain technology.
KAIST also signed a memorandum of understanding for cooperation in researches in Oriental medicine with three institutions, KRIBB, Daegu Hanny University and Korea Institute of Oriental Medicine.
The agreement calls for the four institutions to conduct joint researches in traditional sciences and Oriental medicine based on systems biology, develop manpower in related fields and share academic and research information.
The agreement is expected to provide impetus to reinforcing competitiveness in compound and convergence technologies and discover new properties in Oriental medicine, according to KAIST authorities.
2008.10.16 View 15105 -
KAIST Professor Named International Research Grant Reviewer
Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, was appointed as a research grant review committee member of the international Human Frontier Science Program (HFSP) for 2008-2009, university authorities reported.
The HFSP is a funding agency that supports international collaboration in interdisciplinary, basic research in the life sciences. It was initiated in 1989 by G7 countries as the sole funding program for international researches in neuroscience and molecular biology. The HFSP now has a membership of 35 countries and Korea joined the program in 2004. Prof. Cho will be responsible for reviewing grant applications in the field of systems biology.
Prof. Cho received B.S., M.S. and Ph.D. degrees in electrical engineering from KAIST in 1993, 1995, and 1998, respectively. He has been working as a director of the KAIST Institute for the BioCentury and KAIST"s Laboratory for Systems Biology and Bio-Inspired Engineering. He has been serving on editorial advisory boards of various international science journals, including Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007) and Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007).
He is a senior member of the Engineering in Medicine and Biology Society (EMBS) affiliated with the Institute of Electronics and Electrical Engineers (IEEE). His research interests cover the areas of systems science with bio-medical applications, especially systems biology and bio-inspired engineering based on molecular systems biology.
2008.07.18 View 17421 -
Professor Chan Beum Park, requested for joint international research by a German biotechnology enterprise.
- Bitop AG (Germany) requested a joint development of medicines for Alzheimer’s disease
- The meaning of the financial support by European enterprise to the research result of domestic university.
Professor Chan Beum Park (Department of Materials Science and Engineering in KAIST/ President Nam Pyo Suh) has been entrusted with a joint international research for the development of medicines for Alzheimer’s disease from Bitop AG, German biotechnology enterprise.
KAIST recently agreed with Bitop AG to cooperate for a research program pursuing the development of inhibitors that inhibit the formation of plaque relevant to amyloid diseases like Alzheimer’s disease. Based on this agreement, KAIST will be provided with a financial support of sixty thousands Euro (about 74 million won) from Bitop AG.
Professor Park will perform the screening of inhibitors, which are the core of the research, and KAIST will share patent rights from the research with Bitop AG.
It is known that various degenerative nerve diseases like Alzheimer’s disease, Parkinson’s disease, mad cow disease, and so on arise mainly from the accumulation of pathological protein plaque termed amyloid, and environmental stress accelerates the diseases.
So far, no effective remedy has been developed for amyloid diseases.
Recently, the use of chemicals inhibiting the formation of amyloid has been raised as a potential remedy.
Natural small stress molecules extracted from microbes growing in extreme environments like volcanic region on the bottom of the deep sea, etc. are gaining attention as an amyloid inhibitor.
Professor Park found out for the first time in the world that Anti-stress materials are effective in inhibiting the formation of amyloid plaque and published that fact in several renowned European scientific journals.
After that, Professor Park was requested by Bitop AG for a joint research and has studied for the development of medicines for Alzheimer’s disease using various kinds of Anti-stress materials.
Professor Park said, “I’d like to grant a highly valuable meaning to this entrustment since it implies that European enterprises perceive the value of the research result by domestic universities and hope to promote research and development by providing practical financial support, etc. I wish this time’s entrustment will be a momentum to advance Korea’s research level one step higher through active joint researches with enterprises or institutes in U.S. and Europe as well as Bitop AG.”
Bitop AG is a German enterprise that produces various Anti-stress materials coming from extreme-loving microbes.
Currently, Anti-stress materials are being sold mainly as protein and cell protectants, cosmetic additives, health supplement, etc.
Anti-stress materials extracted from microbes well growing in extreme environment of one hundred centigrade or more are expected to perform a role of inhibitors that inhibit the formation of amyloid plaque, the main factor of stress-related degenerative nerve diseases like Alzheimer’s disease, etc. Such Anti-stress materials are gaining attention as a future medicine for Alzheimer’s disease, etc.
2006.09.05 View 14083