College+of+Engineering
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A KAIST-SNUH Team Devises a Way to Make Mathematical Predictions to find Metabolites Related to Somatic Mutations in Cancers
Cancer is characterized by abnormal metabolic processes different from those of normal cells. Therefore, cancer metabolism has been extensively studied to develop effective diagnosis and treatment strategies. Notable achievements of cancer metabolism studies include the discovery of oncometabolites* and the approval of anticancer drugs by the U.S. Food and Drug Administration (FDA) that target enzymes associated with oncometabolites. Approved anticancer drugs such as ‘Tibsovo (active ingredient: ivosidenib)’ and ‘Idhifa (active ingredient: enasidenib)’ are both used for the treatment of acute myeloid leukemia. Despite such achievements, studying cancer metabolism, especially oncometabolites, remains challenging due to time-consuming and expensive methodologies such as metabolomics. Thus, the number of confirmed oncometabolites is very small although a relatively large number of cancer-associated gene mutations have been well studied.
*Oncometabolite: A metabolite that shows pro-oncogenic function when abnormally accumulated in cancer cells. An oncometabolite is often generated as a result of gene mutations, and this accumulation promotes the growth and survival of cancer cells. Representative oncometabolites include 2-hydroxyglutarate, succinate, and fumarate.
On March 18th, a KAIST research team led by Professor Hyun Uk Kim from the Department of Chemical and Biomolecular Engineering developed a computational workflow that systematically predicts metabolites and metabolic pathways associated with somatic mutations in cancer through collaboration with research teams under Prof Youngil Koh, Prof. Hongseok Yun, and Prof. Chang Wook Jeong from Seoul National University Hospital.
The research teams have successfully reconstructed patient-specific genome-scale metabolic models (GEMs)* for 1,043 cancer patients across 24 cancer types by integrating publicly available cancer patients’ transcriptome data (i.e., from international cancer genome consortiums such as PCAWG and TCGA) into a generic human GEM. The resulting patient-specific GEMs make it possible to predict each patient’s metabolic phenotypes.
*Genome-scale metabolic model (GEM): A computational model that mathematically describes all of the biochemical reactions that take place inside a cell. It allows for the prediction of the cell’s metabolic phenotypes under various genetic and/or environmental conditions.
< Figure 1. Schematic diagram of a computational methodology for predicting metabolites and metabolic pathways associated with cancer somatic mutations. of a computational methodology for predicting metabolites and metabolic pathways associated with cancer somatic mutations. >
The team developed a four-step computational workflow using the patient-specific GEMs from 1,043 cancer patients and somatic mutation data obtained from the corresponding cancer patients. This workflow begins with the calculation of the flux-sum value of each metabolite by simulating the patient-specific GEMs. The flux-sum value quantifies the intracellular importance of a metabolite. Next, the workflow identifies metabolites that appear to be significantly associated with specific gene mutations through a statistical analysis of the predicted flux-sum data and the mutation data. Finally, the workflow selects altered metabolic pathways that significantly contribute to the biosynthesis of the predicted oncometabolite candidates, ultimately generating metabolite-gene-pathway sets as an output.
The two co-first authors, Dr. GaRyoung Lee (currently a postdoctoral fellow at the Dana-Farber Cancer Institute and Harvard Medical School) and Dr. Sang Mi Lee (currently a postdoctoral fellow at Harvard Medical School) said, “The computational workflow developed can systematically predict how genetic mutations affect cellular metabolism through metabolic pathways. Importantly, it can easily be applied to different types of cancer based on the mutation and transcriptome data of cancer patient cohorts.”
Prof. Kim said, “The computational workflow and its resulting prediction outcomes will serve as the groundwork for identifying novel oncometabolites and for facilitating the development of various treatment and diagnosis strategies”.
This study, which was supported by the National Research Foundation of Korea, has been published online in Genome Biology, a representative journal in the field of biotechnology and genetics, under the title "Prediction of metabolites associated with somatic mutations in cancers by using genome‑scale metabolic models and mutation data".
2024.03.18 View 3257 -
KAIST Develops Healthcare Device Tracking Chronic Diabetic Wounds
A KAIST research team has developed an effective wireless system that monitors the wound healing process by tracking the spatiotemporal temperature changes and heat transfer characteristics of damaged areas such as diabetic wounds.
On the 5th of March, KAIST (represented by President Kwang Hyung Lee) announced that the research team led by Professor Kyeongha Kwon from KAIST’s School of Electrical Engineering, in association with Chung-Ang University professor Hanjun Ryu, developed digital healthcare technology that tracks the wound healing process in real time, which allows appropriate treatments to be administered.
< Figure 1. Schematic illustrations and diagrams of real-time wound monitoring systems. >
The skin serves as a barrier protecting the body from harmful substances, therefore damage to the skin may cause severe health risks to patients in need of intensive care. Especially in the case of diabetic patients, chronic wounds are easily formed due to complications in normal blood circulation and the wound healing process. In the United States alone, hundreds of billions of dollars of medical costs stem from regenerating the skin from such wounds. While various methods exist to promote wound healing, personalized management is essential depending on the condition of each patient's wounds.
Accordingly, the research team tracked the heating response within the wound by utilizing the differences in temperature between the damaged area and the surrounding healthy skin. They then measured heat transfer characteristics to observe moisture changes near the skin surface, ultimately establishing a basis for understanding the formation process of scar tissue. The team conducted experiments using diabetic mice models regarding the delay in wound healing under pathological conditions, and it was demonstrated that the collected data accurately tracks the wound healing process and the formation of scar tissue.
To minimize the tissue damage that may occur in the process of removing the tracking device after healing, the system integrates biodegradable sensor modules capable of natural decomposition within the body. These biodegradable modules disintegrate within the body after use, thus reducing the risk of additional discomfort or tissue damage upon device removal. Furthermore, the device could one day be used for monitoring inside the wound area as there is no need for removal.
Professor Kyeongha Kwon, who led the research, anticipates that continuous monitoring of wound temperature and heat transfer characteristics will enable medical professionals to more accurately assess the status of diabetic patients' wounds and provide appropriate treatment. He further predicted that the implementation of biodegradable sensors allows for the safe decomposition of the device after wound healing without the need for removal, making live monitoring possible not only in hospitals but also at home.
The research team plans to integrate antimicrobial materials into this device, aiming to expand its technological capabilities to enable the observation and prevention of inflammatory responses, bacterial infections, and other complications. The goal is to provide a multi-purpose wound monitoring platform capable of real-time antimicrobial monitoring in hospitals or homes by detecting changes in temperature and heat transfer characteristics indicative of infection levels.
< Image 1. Image of the bioresorbable temperature sensor >
The results of this study were published on February 19th in the international journal Advanced Healthcare Materials and selected as the inside back cover article, titled "Materials and Device Designs for Wireless Monitoring of Temperature and Thermal Transport Properties of Wound Beds during Healing."
This research was conducted with support from the Basic Research Program, the Regional Innovation Center Program, and the BK21 Program.
2024.03.11 View 3379 -
The World’s First Hacking-preventing Cryptographic Semiconductor Chip
With the dramatic increase in the amount of information exchanged between components or devices in the 5G/6G era, such as for the Internet of Things (IoT) and autonomous driving, hacking attacks are becoming more sophisticated. Consequently, enhancing security functions is essential for safely transmitting data between and among devices.
On February 29th, a KAIST research team led by Professors Yang-gyu Choi and Seung-tak Ryu from the School of Electrical Engineering announced the successful development of the world's first security cryptographic semiconductor.
The team has developed the Cryptoristor, a cryptographic transistor based on FinFET technology, produced through a 100% silicon-compatible process, for the first time in the world. Cryptoristor is a random number generator (RNG) with unparalleled characteristics, featuring a unique structure comprising a single transistor and a distinctive mechanism.
In all security environments, including artificial intelligence, the most crucial element is the RNG. In the most commonly used security chip, the Advanced Encryption Standard (AES), the RNG is a core component, occupying approximately 75% of the total chip area and more than 85% of its energy consumption. Hence, there is an urgent need for the development of low-power/ultra-small RNGs suitable for mobile or IoT devices.
Existing RNGs come with limitations as they lack compatibility with silicon CMOS processes and circuit-based RNGs occupy a large surface area.
In contrast, the team’s newly developed Cryptoristor, a cryptographic semiconductor based on a single-component structure, consumes and occupies less than .001 of the power and area compared to the current chips being used. Utilizing the inherent randomness of FinFETs, fabricated on a Silicon-on-Insulator (SOI) substrate with an insulating layer formed beneath the silicon, the team developed an RNG that unpredictably produces zeroes and ones.
< Figure 1. Conceptual diagram of the security cryptographic transistor device. >
Generally speaking, preventing hackers from predicting the encrypted algorithms during data exchanges through mobile devices is pivotal. Therefore, this method ensures unpredictability by generating random sequences of zeroes and ones that change every time.
Moreover, while the Cryptoristor-based RNG research is the world's first of its kind without any international implementation cases, it shares the same transistor structure as existing logic or memory components. This enables 100% production through rapid mass production processes using existing semiconductor facilities at a low cost.
Seung-il Kim, a PhD student who led the research, explained the significance of the study, stating, "As a cryptographic semiconductor, the ultra-small/low-power random number generator enhances security through its distinctive unpredictability, supporting safe hyperconnectivity with secure transmissions between chips or devices. Particularly, compared to previous research, it offers excellent advantages in terms of energy consumption, integration density, and cost, making it suitable for IoT device environments."
This research, with master’s student Hyung-jin Yoo as the co-author, was officially published in the online edition of Science Advances, a sister journal of Science, in February 2024 (research paper title: Cryptographic transistor for true random number generator with low power consumption).
This research received support from the Next-Generation Intelligent Semiconductor Technology Development Project and the Core Technology Development Project for the National Semiconductor Research Laboratory.
2024.03.07 View 4113 -
KAIST Research Team Creates the Scent of Jasmine from Microorganisms
The fragrance of jasmine and ylang-ylang, used widely in the manufacturing of cosmetics, foods, and beverages, can be produced by direct extraction from their respective flowers. In reality, this makes it difficult for production to meet demand, so companies use benzyl acetate, a major aromatic component of the two fragrances that is chemically synthesized from raw materials derived from petroleum.
On February 26, a KAIST research team led by Research Professor Kyeong Rok Choi from the BioProcess Engineering Research Center and Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering revealed the development of the first microbial process to effectively produce benzyl acetate, an industrially useful compound, from renewable carbon sources such as glucose. The results were published in their paper titled “A microbial process for the production of benzyl acetate”.
< Figure 1. Production of benzyl acetate through co-culture of upstream and downstream strains harboring the benzoic acid-dependent pathway. >
The team, led by Distinguished Professor Lee, aimed to produce benzyl acetate through an environmentally friendly and sustainable method, and developed an Escherichia coli strand to convert glucose into benzyl acetate through system metabolic engineering*.
*System metabolic engineering: a field of research founded by Distinguished Professor Lee to effectively develop microbial cell plants, a core component of the bio-industry that will replace the existing chemical industry, which is highly dependent on petroleum.
The research team developed a metabolic pathway that biosynthesizes benzyl acetate from benzoic acid derived from glucose, and successfully produced benzyl acetate by co-culturing** the strain.
**co-culture: simultaneously synthesizing two or more types of microorganisms in a mixture
However, it has been confirmed that the enzyme used to convert benzoic acid into benzyl acetate in this co-culturing technique acts non-specifically on an intermediate product during benzoic acid biosynthesis, producing a by-product called cinnamyl acetate. This process consumes the intermediate product needed for benzoic acid biosynthesis, thereby reducing the production efficiency of the target compound, benzyl acetate.
To overcome this problem, Distinguished Professor Lee and his team devised a delayed co-culture method, where they first produced benzoic acid in the earlier stages of fermentation by only culturing the top strain that produces benzoic acid from glucose, and later inoculated the bottom strain to convert the accumulated benzoic acid in the culture medium into benzyl acetate.
By applying this co-culture technique, the team suppressed the formation of by-products without further strain improvement or applying additional enzymes, and multiplied the concentration of the target compound by 10 times, producing 2.2 g/L of benzyl acetate. In addition, the team confirmed its potential for the commercial production of benzyl acetate through a technical economic analysis on this microbial process.
< Figure 2. Delayed co-culture of the Bn1 and Bn-BnAc3 strains for improved production of benzyl acetate through the benzoic acid-independent pathway.>
Research Professor Keyong Rok Choi, who was the first author of this paper, said, “This work is significant in that we have developed an effective microbial process to produce the industrially useful compound benzyl acetate, and also in that we have suggested a new approach to overcome the target chemical efficiency diminution and by-product formation issues caused commonly through non-specific enzyme activities during metabolic engineering.”
Distinguished Professor Lee said, “If we can increase the variety and number of microbial processes that produce useful chemicals through sustainable methods and at the same time develop effective strategies to solve chronic and inevitable problems that arise during microbial strain development, we will be able to accelerate the transition from the petrochemical industry into the eco-friendly and sustainable bio-industry.
This work was published online in Nature Chemical Engineering, issued by Nature.
This research was supported by the ‘Implementation of Intelligent Cell Factory Technology (PI: Distinguished Professor Sang Yup Lee) Project by the Ministry of Science and ICT, and the ‘Development of Protein Production Technology from Inorganic Substances through Microbiological Metabolic System Control’ (PI: Research Professor Kyeong Rok Choi) by the Agricultural Microbiological Project Group at the Rural Development Administration.
2024.03.05 View 3444 -
KAIST Team Develops an Insect-Mimicking Semiconductor to Detect Motion
The recent development of an “intelligent sensor” semiconductor that mimics the optic nerve of insects while operating at ultra-high speeds and low power offers extensive expandability into various innovative technologies. This technology is expected to be applied to various fields including transportation, safety, and security systems, contributing to both industry and society.
On February 19, a KAIST research team led by Professor Kyung Min Kim from the Department of Materials Science and Engineering (DMSE) announced the successful developed an intelligent motion detector by merging various memristor* devices to mimic the visual intelligence** of the optic nerve of insects.
*Memristor: a “memory resistor” whose state of resistance changes depending on the input signal
**Visual intelligence: the ability to interpret visual information and perform calculations within the optic nerve
With the recent advances in AI technology, vision systems are being improved by utilizing AI in various tasks such as image recognition, object detection, and motion analysis. However, existing vision systems typically recognize objects and their behaviour from the received image signals using complex algorithms. This method requires a significant amount of data traffic and higher power consumption, making it difficult to apply in mobile or IoT devices.
Meanwhile, insects are known to be able to effectively process visual information through an optic nerve circuit called the elementary motion detector, allowing them to detect objects and recognize their motion at an advanced level. However, mimicking this pathway using conventional silicon integrated circuit (CMOS) technology requires complex circuits, and its implementation into actual devices has thus been limited.
< Figure 1. Working principle of a biological elementary motion detection system. >
Professor Kyung Min Kim’s research team developed an intelligent motion detecting sensor that operates at a high level of efficiency and ultra-high speeds. The device has a simple structure consisting of only two types of memristors and a resistor developed by the team. The two different memristors each carry out a signal delay function and a signal integration and ignition function, respectively. Through them, the team could directly mimic the optic nerve of insects to analyze object movement.
< Figure 2. (Left) Optical image of the M-EMD device in the left panel (scale bar 200 μm) and SEM image of the device in the right panel (scale bar: 20 μm). (Middle) Responses of the M-EMD in positive direction. (Right) Responses of the M-EMD in negative direction. >
To demonstrate its potential for practical applications, the research team used the newly developed motion detector to design a neuromorphic computing system that can predict the path of a vehicle. The results showed that the device used 92.9% less energy compared to existing technology and predicted motion with more accuracy.
< Figure 3. Neuromorphic computing system configuration based on motion recognition devices >
Professor Kim said, “Insects make use of their very simple visual intelligence systems to detect the motion of objects at a surprising high speed. This research is significant in that we could mimic the functions of a nerve using a memristor device.” He added, “Edge AI devices, such as AI-topped mobile phones, are becoming increasingly important. This research can contribute to the integration of efficient vision systems for motion recognition, so we expect it to be applied to various fields such as autonomous vehicles, vehicle transportation systems, robotics, and machine vision.”
This research, conducted by co-first authors Hanchan Song and Min Gu Lee, both Ph.D. candidates at KAIST DMSE, was published in the online issue of Advanced Materials on January 29.
This research was supported by the Mid-Sized Research Project by the National Research Foundation of Korea, the Next-Generation Intelligent Semiconductor Technology Development Project, the PIM Artificial Intelligence Semiconductor Core Technology Development Project, the National Nano Fab Center, and the Leap Research Project by KAIST.
2024.02.29 View 3938 -
KAIST to begin Joint Research to Develop Next-Generation LiDAR System with Hyundai Motor Group
< (From left) Jong-Soo Lee, Executive Vice President at Hyundai Motor, Sang-Yup Lee, Senior Vice President for Research at KAIST >
The ‘Hyundai Motor Group-KAIST On-Chip LiDAR Joint Research Lab’ was opened at KAIST’s main campus in Daejeon to develop LiDAR sensors for advanced autonomous vehicles.
The joint research lab aims to develop high-performance and compact on-chip sensors and new signal detection technology, which are essential in the increasingly competitive autonomous driving market. On-chip sensors, which utilize semiconductor manufacturing technology to add various functions, can reduce the size of LiDAR systems compared to conventional methods and secure price competitiveness through mass production using semiconductor fabrication processes.
The joint research lab will consist of about 30 researchers, including the Hyundai-Kia Institute of Advanced Technology Development research team and KAIST professors Sanghyeon Kim, Sangsik Kim, Wanyeong Jung, and Hamza Kurt from KAIST’s School of Electrical Engineering, and will operate for four years until 2028.
KAIST will be leading the specialized work of each research team, such as for the development of silicon optoelectronic on-chip LiDAR components, the fabrication of high-speed, high-power integrated circuits to run the LiDAR systems, and the optimization and verification of LiDAR systems.
Hyundai Motor and Kia, together with Hyundai NGV, a specialized industry-academia cooperation institution, will oversee the operation of the joint research lab and provide support such as monitoring technological trends, suggesting research directions, deriving core ideas, and recommending technologies and experts to enhance research capabilities.
A Hyundai Motor Group official said, "We believe that this cooperation between Hyundai Motor Company and Kia, the leader in autonomous driving technology, and KAIST, the home of world-class technology, will hasten the achievement of fully autonomous driving." He added, "We will do our best to enable the lab to produce tangible results.”
Professor Sanghyeon Kim said, "The LiDAR sensor, which serves as the eyes of a car, is a core technology for future autonomous vehicle development that is essential for automobile companies to internalize."
2024.02.27 View 4377 -
Genome Sequencing Unveils Mutational Impacts of Radiation on Mammalian Cells
Recent release of the waste water from Japan's Fukushima nuclear disaster stirred apprehension regarding the health implications of radiation exposure. Classified as a Group 1 carcinogen, ionizing radiation has long been associated with various cancers and genetic disorders, as evidenced by survivors and descendants of atomic bombings and the Chernobyl disaster. Despite much smaller amount, we remain consistently exposed to low levels of radiation in everyday life and medical procedures.
Radiation, whether in the form of high-energy particles or electromagnetic waves, is conventionally known to break our cellular DNA, leading to cancer and genetic disorders. Yet, our understanding of the quantitative and qualitative mutational impacts of ionizing radiation has been incomplete.
On the 14th, Professor Young Seok Ju and his research team from KAIST, in collaboration with Dr. Tae Gen Son from the Dongnam Institute of Radiological and Medical Science, and Professors Kyung Su Kim and Ji Hyun Chang from Seoul National University, unveiled a breakthrough. Their study, led by joint first authors Drs. Jeonghwan Youk, Hyun Woo Kwon, Joonoh Lim, Eunji Kim and Tae-Woo Kim, titled "Quantitative and qualitative mutational impact of ionizing radiation on normal cells," was published in Cell Genomics.
Employing meticulous techniques, the research team comprehensively analyzed the whole-genome sequences of cells pre- and post-radiation exposure, pinpointing radiation-induced DNA mutations. Experiments involving cells from different organs of humans and mice exposed to varying radiation doses revealed mutation patterns correlating with exposure levels. (Figure 1)
Notably, exposure to 1 Gray (Gy) of radiation resulted in on average 14 mutations in every post-exposure cell. (Figure 2) Unlike other carcinogens, radiation-induced mutations primarily comprised short base deletions and a set of structural variations including inversions, translocations, and various complex genomic rearrangements. (Figure 3) Interestingly, experiments subjecting cells to low radiation dose rate over 100 days demonstrated that mutation quantities, under equivalent total radiation doses, mirrored those of high-dose exposure.
"Through this study, we have clearly elucidated the effects of radiation on cells at the molecular level," said Prof. Ju at KAIST. "Now we understand better how radiation changes the DNA of our cells," he added.
Dr. Son from the Dongnam Institute of Radiological and Medical Science stated, "Based on this study, we will continue to research the effects of very low and very high doses of radiation on the human body," and further remarked, "We will advance the development of safe and effective radiation therapy techniques."
Professors Kim and Chang from Seoul National University College of Medicine expressed their views, saying, "Through this study, we believe we now have a tool to accurately understand the impact of radiation on human DNA," and added, "We hope that many subsequent studies will emerge using the research methodologies employed in this study."
This research represents a significant leap forward in radiation studies, made possible through collaborative efforts and interdisciplinary approaches. This pioneering research engaged scholars from diverse backgrounds, spanning from the Genetic Engineering Research Institute at Seoul National University, the Cambridge Stem Cell Institute in the UK, the Institute for Molecular Biotechnology in Austria (IMBA), and the Genome Insight Inc. (a KAIST spin-off start-up). This study was supported by various institutions including the National Research Foundation of Korea, Dongnam Institute of Radiological and Medical Science (supported by Ministry of Science and ICT, the government of South Korea), the Suh Kyungbae Foundation, the Human Frontier Science Program (HFSP), and the Korea University Anam Hospital Korea Foundation for the Advancement of Science and Creativity, the Ministry of Science and ICT, and the National R&D Program.
2024.02.15 View 3844 -
Team KAIST placed among top two at MBZIRC Maritime Grand Challenge
Representing Korean Robotics at Sea: KAIST’s 26-month strife rewarded
Team KAIST placed among top two at MBZIRC Maritime Grand Challenge
- Team KAIST, composed of students from the labs of Professor Jinwhan Kim of the Department of Mechanical Engineering and Professor Hyunchul Shim of the School of Electrical and Engineering, came through the challenge as the first runner-up winning the prize money totaling up to $650,000 (KRW 860 million).
- Successfully led the autonomous collaboration of unmanned aerial and maritime vehicles using cutting-edge robotics and AI technology through to the final round of the competition held in Abu Dhabi from January 10 to February 6, 2024.
KAIST (President Kwang-Hyung Lee), reported on the 8th that Team KAIST, led by students from the labs of Professor Jinwhan Kim of the Department of Mechanical Engineering and Professor Hyunchul Shim of the School of Electrical Engineering, with Pablo Aviation as a partner, won a total prize money of $650,000 (KRW 860 million) at the Maritime Grand Challenge by the Mohamed Bin Zayed International Robotics Challenge (MBZIRC), finishing first runner-up.
This competition, which is the largest ever robotics competition held over water, is sponsored by the government of the United Arab Emirates and organized by ASPIRE, an organization under the Abu Dhabi Ministry of Science, with a total prize money of $3 million.
In the competition, which started at the end of 2021, 52 teams from around the world participated and five teams were selected to go on to the finals in February 2023 after going through the first and second stages of screening. The final round was held from January 10 to February 6, 2024, using actual unmanned ships and drones in a secluded sea area of 10 km2 off the coast of Abu Dhabi, the capital of the United Arab Emirates. A total of 18 KAIST students and Professor Jinwhan Kim and Professor Hyunchul Shim took part in this competition at the location at Abu Dhabi.
Team KAIST will receive $500,000 in prize money for taking second place in the final, and the team’s prize money totals up to $650,000 including $150,000 that was as special midterm award for finalists.
The final mission scenario is to find the target vessel on the run carrying illegal cargoes among many ships moving within the GPS-disabled marine surface, and inspect the deck for two different types of stolen cargo to recover them using the aerial vehicle to bring the small cargo and the robot manipulator topped on an unmanned ship to retrieve the larger one. The true aim of the mission is to complete it through autonomous collaboration of the unmanned ship and the aerial vehicle without human intervention throughout the entire mission process. In particular, since GPS cannot be used in this competition due to regulations, Professor Jinwhan Kim's research team developed autonomous operation techniques for unmanned ships, including searching and navigating methods using maritime radar, and Professor Hyunchul Shim's research team developed video-based navigation and a technology to combine a small autonomous robot with a drone.
The final mission is to retrieve cargo on board a ship fleeing at sea through autonomous collaboration between unmanned ships and unmanned aerial vehicles without human intervention. The overall mission consists the first stage of conducting the inspection to find the target ship among several ships moving at sea and the second stage of conducting the intervention mission to retrieve the cargoes on the deck of the ship. Each team was given a total of three opportunities, and the team that completed the highest-level mission in the shortest time during the three attempts received the highest score.
In the first attempt, KAIST was the only team to succeed in the first stage search mission, but the competition began in earnest as the Croatian team also completed the first stage mission in the second attempt. As the competition schedule was delayed due to strong winds and high waves that continued for several days, the organizers decided to hold the finals with the three teams, including the Team KAIST and the team from Croatia’s the University of Zagreb, which completed the first stage of the mission, and Team Fly-Eagle, a team of researcher from China and UAE that partially completed the first stage. The three teams were given the chance to proceed to the finals and try for the third attempt, and in the final competition, the Croatian team won, KAIST took the second place, and the combined team of UAE-China combined team took the third place. The final prize to be given for the winning team is set at $2 million with $500,000 for the runner-up team, and $250,000 for the third-place.
Professor Jinwhan Kim of the Department of Mechanical Engineering, who served as the advisor for Team KAIST, said, “I would like to express my gratitude and congratulations to the students who put in a huge academic and physical efforts in preparing for the competition over the past two years. I feel rewarded because, regardless of the results, every bit of efforts put into this up to this point will become the base of their confidence and a valuable asset in their growth into a great researcher.” Sol Han, a doctoral student in mechanical engineering who served as the team leader, said, “I am disappointed of how narrowly we missed out on winning at the end, but I am satisfied with the significance of the output we’ve got and I am grateful to the team members who worked hard together for that.”
HD Hyundai, Rainbow Robotics, Avikus, and FIMS also participated as sponsors for Team KAIST's campaign.
2024.02.09 View 6394 -
A KAIST Research Team Develops a Novel “Bone Bandage” Material for Cracked Bones
Bone regeneration is a complex process, and existing methods to aid regeneration including transplants and growth factor transmissions face limitations such as the high cost. But recently, a piezoelectric material that can promote the growth of bone tissue has been developed.
A KAIST research team led by Professor Seungbum Hong from the Department of Materials Science and Engineering (DMSE) announced on January 25 the development of a biomimetic scaffold that generates electrical signals upon the application of pressure by utilizing the unique osteogenic ability of hydroxyapatite (HAp). This research was conducted in collaboration with a team led by Professor Jangho Kim from the Department of Convergence Biosystems Engineering at Chonnam National University.
HAp is a basic calcium phosphate material found in bones and teeth. This biocompatible mineral substance is also known to prevent tooth decay and is often used in toothpaste.
Previous studies on piezoelectric scaffolds confirmed the effects of piezoelectricity on promoting bone regeneration and improving bone fusion in various polymer-based materials, but were limited in simulating the complex cellular environment required for optimal bone tissue regeneration. However, this research suggests a new method for utilizing the unique osteogenic abilities of HAp to develop a material that mimics the environment for bone tissue in a living body.
< Figure 1. Design and characterization of piezoelectrically and topographically originated biomimetic scaffolds. (a) Schematic representation of the enhanced bone regeneration mechanism through electrical and topographical cues provided by HAp-incorporated P(VDF-TrFE) scaffolds. (b) Schematic diagram of the fabrication process. >
The research team developed a manufacturing process that fuses HAp with a polymer film. The flexible and free-standing scaffold developed through this process demonstrated its remarkable potential for promoting bone regeneration through in-vitro and in-vivo experiments in rats.
The team also identified the principles of bone regeneration that their scaffold is based on. Using atomic force microscopy (AFM), they analysed the electrical properties of the scaffold and evaluated the detailed surface properties related to cell shape and cell skeletal protein formation. They also investigated the effects of piezoelectricity and surface properties on the expression of growth factors.
Professor Hong from KAIST’s DMSE said, “We have developed a HAp-based piezoelectric composite material that can act like a ‘bone bandage’ through its ability to accelerate bone regeneration.” He added, “This research not only suggests a new direction for designing biomaterials, but is also significant in having explored the effects of piezoelectricity and surface properties on bone regeneration.”
This research, conducted by co-first authors Soyun Joo and Soyeon Kim from Professor Hong’s group, was published on ACS Applied Materials & Interfaces on January 4 under the title “Piezoelectrically and Topographically Engineered Scaffolds for Accelerating Bone Regeneration”. From Professor Kim’s group, Ph.D. candidate Yonghyun Gwon also participated as co-first author, and Professor Kim himself as a corresponding author.
< Figure 2. Analysis of piezoelectric and surface properties of the biomimetic scaffolds using atomic force microscopy. (a) PFM amplitude and phase images of box-poled composite scaffolds. The white bar represents 2 μm. (b) 3D representations of composite scaffolds paired with typical 2D line sections. (c) In vivo bone regeneration micro-CT analysis, (d) schematic representation of filler-derived electrical origins in bone regeneration. >
This research was supported by the KAIST Research and Development Team, the KUSTAR-KAIST Joint Research Center, the KAIST Global Singularity Project, and the government-funded Basic Research Project by the National Research Foundation of Korea.
2024.02.01 View 4214 -
KAIST Research Team Develops Sweat-Resistant Wearable Robot Sensor
New electromyography (EMG) sensor technology that allows the long-term stable control of wearable robots and is not affected by the wearer’s sweat and dead skin has gained attention recently. Wearable robots are devices used across a variety of rehabilitation treatments for the elderly and patients recovering from stroke or trauma.
A joint research team led by Professor Jae-Woong Jung from the KAIST School of Electrical Engineering (EE) and Professor Jung Kim from the KAIST Department of Mechanical Engineering (ME) announced on January 23rd that they have successfully developed a stretchable and adhesive microneedle sensor that can electrically sense physiological signals at a high level without being affected by the state of the user’s skin.
For wearable robots to recognize the intentions behind human movement for their use in rehabilitation treatment, they require a wearable electrophysiological sensor that gives precise EMG measurements. However, existing sensors often show deteriorating signal quality over time and are greatly affected by the user’s skin conditions. Furthermore, the sensor’s higher mechanical hardness causes noise since the contact surface is unable to keep up with the deformation of the skin. These shortcomings limit the reliable, long-term control of wearable robots.
< Figure 1. Design and working concept of the Stretchable microNeedle Adhesive Patch (SNAP). (A) Schematic illustration showing the overall system configuration and application of SNAP. (B) Exploded view schematic diagram of a SNAP, consisting of stretchable serpentine interconnects, Au-coated Si microneedle, and ECA made of Ag flakes–silicone composite. (C) Optical images showing high mechanical compliance of SNAP. >
However, the recently developed technology is expected to allow long-term and high-quality EMG measurements as it uses a stretchable and adhesive conducting substrate integrated with microneedle arrays that can easily penetrate the stratum corneum without causing discomfort. Through its excellent performance, the sensor is anticipated to be able to stably control wearable robots over a long period of time regardless of the wearer’s changing skin conditions and without the need for a preparation step that removes sweat and dead cells from the surface of their skin.
The research team created a stretchable and adhesive microneedle sensor by integrating microneedles into a soft silicon polymer substrate. The hard microneedles penetrate through the stratum corneum, which has high electrical resistance. As a result, the sensor can effectively lower contact resistance with the skin and obtain high-quality electrophysiological signals regardless of contamination. At the same time, the soft and adhesive conducting substrate can adapt to the skin’s surface that stretches with the wearer’s movement, providing a comfortable fit and minimizing noise caused by movement.
< Figure 2. Demonstration of the wireless Stretchable microNeedle Adhesive Patch (SNAP) system as an Human-machine interfaces (HMI) for closed-loop control of an exoskeleton robot. (A) Illustration depicting the system architecture and control strategy of an exoskeleton robot. (B) The hardware configuration of the pneumatic back support exoskeleton system. (C) Comparison of root mean square (RMS) of electromyography (EMG) with and without robotic assistance of pretreated skin and non-pretreated skin. >
To verify the usability of the new patch, the research team conducted a motion assistance experiment using a wearable robot. They attached the microneedle patch on a user’s leg, where it could sense the electrical signals generated by the muscle. The sensor then sent the detected intention to a wearable robot, allowing the robot to help the wearer lift a heavy object more easily.
Professor Jae-Woong Jung, who led the research, said, “The developed stretchable and adhesive microneedle sensor can stability detect EMG signals without being affected by the state of a user’s skin. Through this, we will be able to control wearable robots with higher precision and stability, which will help the rehabilitation of patients who use robots.”
The results of this research, written by co-first authors Heesoo Kim and Juhyun Lee, who are both Ph.D. candidates in the KAIST School of EE, were published in Science Advances on January 17th under the title “Skin-preparation-free, stretchable microneedle adhesive patches for reliable electrophysiological sensing and exoskeleton robot control”.
This research was supported by the Bio-signal Sensor Integrated Technology Development Project by the National Research Foundation of Korea, the Electronic Medicinal Technology Development Project, and the Step 4 BK21 Project.
2024.01.30 View 4074 -
KAIST Professor Jiyun Lee becomes the first Korean to receive the Thurlow Award from the American Institute of Navigation
< Distinguished Professor Jiyun Lee from the KAIST Department of Aerospace Engineering >
KAIST (President Kwang-Hyung Lee) announced on January 27th that Distinguished Professor Jiyun Lee from the KAIST Department of Aerospace Engineering had won the Colonel Thomas L. Thurlow Award from the American Institute of Navigation (ION) for her achievements in the field of satellite navigation.
The American Institute of Navigation (ION) announced Distinguished Professor Lee as the winner of the Thurlow Award at its annual awards ceremony held in conjunction with its international conference in Long Beach, California on January 25th. This is the first time a person of Korean descent has received the award.
The Thurlow Award was established in 1945 to honor Colonel Thomas L. Thurlow, who made significant contributions to the development of navigation equipment and the training of navigators. This award aims to recognize an individual who has made an outstanding contribution to the development of navigation and it is awarded to one person each year. Past recipients include MIT professor Charles Stark Draper, who is well-known as the father of inertial navigation and who developed the guidance computer for the Apollo moon landing project.
Distinguished Professor Jiyun Lee was recognized for her significant contributions to technological advancements that ensure the safety of satellite-based navigation systems for aviation. In particular, she was recognized as a world authority in the field of navigation integrity architecture design, which is essential for ensuring the stability of intelligent transportation systems and autonomous unmanned systems. Distinguished Professor Lee made a groundbreaking contribution to help ensure the safety of satellite-based navigation systems from ionospheric disturbances, including those affected by sudden changes in external factors such as the solar and space environment.
She has achieved numerous scientific discoveries in the field of ionospheric research, while developing new ionospheric threat modeling methods, ionospheric anomaly monitoring and mitigation techniques, and integrity and availability assessment techniques for next-generation augmented navigation systems. She also contributed to the international standardization of technology through the International Civil Aviation Organization (ICAO).
Distinguished Professor Lee and her research group have pioneered innovative navigation technologies for the safe and autonomous operation of unmanned aerial vehicles (UAVs) and urban air mobility (UAM). She was the first to propose and develop a low-cost navigation satellite system (GNSS) augmented architecture for UAVs with a near-field network operation concept that ensures high integrity, and a networked ground station-based augmented navigation system for UAM. She also contributed to integrity design techniques, including failure monitoring and integrity risk assessment for multi-sensor integrated navigation systems.
< Professor Jiyoon Lee upon receiving the Thurlow Award >
Bradford Parkinson, professor emeritus at Stanford University and winner of the 1986 Thurlow Award, who is known as the father of GPS, congratulated Distinguished Professor Lee upon hearing that she was receiving the Thurlow Award and commented that her innovative research has addressed many important topics in the field of navigation and her solutions are highly innovative and highly regarded.
Distinguished Professor Lee said, “I am very honored and delighted to receive this award with its deep history and tradition in the field of navigation.” She added, “I will strive to help develop the future mobility industry by securing safe and sustainable navigation technology.”
2024.01.26 View 3411 -
KAIST and Hyundai Motors Collaborate to Develop Ultra-Fast Hydrogen Leak Detection within 0.6 Seconds
Recently, as the spread of eco-friendly hydrogen cars increases, the importance of hydrogen sensors is also on the rise. In particular, achieving technology to detect hydrogen leaks within one second remains a challenging task. Accordingly, the development of the world's first hydrogen sensor that meets the performance standards of the U.S. Department of Energy has become a hot topic.
A team at KAIST led by Dr. Min-Seung Jo from Professor Jun-Bo Yoon's team in the Department of Electrical and Electronic Engineering has successfully achieved all of its desired performance indicators, meeting globally recognized standards through collaboration with the Electromagnetic Energy Materials Research Team at Hyundai Motor Company's Basic Materials Research Center and Professor Min-Ho Seo of Pusan National University. On January 10th, the research group announced that the world's first hydrogen sensor with a speed of less than 0.6 seconds had been developed.
In order to secure faster and more stable hydrogen detection technology than existing commercialized hydrogen sensors, the KAIST team began developing a next-generation hydrogen sensor in 2021 together with Hyundai Motor Company, and succeeded after two years of development.
< Figure 1. (Left) The conceptual drawing of the structure of the coplanar heater-integrated hydrogen sensor. Pd nanowire is stably suspended in the air even with its thickness of 20 nm. (Right) A graph of hydrogen sensor performance operating within 0.6 seconds for hydrogen at a concentration of 0.1 to 4% >
Existing hydrogen sensor research has mainly focused on sensing materials, such as catalytic treatments or the alloying of palladium (Pd) materials, which are widely used in hydrogen sensors. Although these studies showed excellent performance with certain performance indicators, they did not meet all of the desired performance indicators and commercialization was limited due to the difficulty of batch processing.
To overcome this, the research team developed a sensor that satisfied all of the performance indicators by combining independent micro/nano structure design and process technology based on pure palladium materials. In addition, considering future mass production, pure metal materials with fewer material restrictions were used rather than synthetic materials, and a next-generation hydrogen sensor was developed that can be mass-produced based on a semiconductor batch process.
The developed device is a differential coplanar device in which the heater and sensing materials are integrated side by side on the same plane to overcome the uneven temperature distribution of existing gas sensors, which have a structure where the heater, insulating layer, and sensing materials are stacked vertically. The palladium nanomaterial, which is a sensing material, has a completely floating structure and is exposed to air from beneath, maximizing the reaction area with a gas to ensure a fast reaction speed. In addition, the palladium sensing material operates at a uniform temperature throughout the entire area, and the research team was able to secure a fast operation speed, wide sensing concentration, and temperature/humidity insensitivity by accurately controlling temperature-sensitive sensing performance.
< Figure 2. Electron microscopy of the coplanar heater-integrated hydrogen sensor (left) Photo of the entire device (top right) Pd nanowire suspended in the air (bottom right) Cross section of Pd nanowire >
The research team packaged the fabricated device with a Bluetooth module to create an integrated module that wirelessly detects hydrogen leaks within one second and then verified its performance. Unlike existing high-performance optical hydrogen sensors, this one is highly portable and can be used in a variety of applications where hydrogen energy is used.
Dr. Min-Seung Jo, who led the research, said, “The results of this research are of significant value as they not only operate at high speeds by exceeding the performance limits of existing hydrogen sensors, but also secure the reliability and stability necessary for actual use, and can be used in various places such as automobiles, hydrogen charging stations, and homes.” He also revealed his future plans, saying, “Through the commercialization of this hydrogen sensor technology, I would like to contribute to advancing the safe and eco-friendly use of hydrogen energy.”
< Figure 3. (Left) Real-time hydrogen detection results from the coplanar heater-integrated hydrogen sensor integrated and packaged in wireless communication and an app for mobile phone. (Middle) LED blinking cycle control in accordance with the hydrogen concentration level. (Right) Results of performance confirmation of the detection within 1 second in a real-time hydrogen leak demo >
The research team is currently working with Hyundai Motor Company to manufacture the device on a wafer scale and then mount it on a vehicle module to further verify detection and durability performance.
This research, conducted by Dr. Min-Seung Jo as the first author, has three patent applications filed in the U.S. and Korea, and was published in the renowned international academic journal 'ACS Nano'. (Paper title: Ultrafast (∼0.6 s), Robust, and Highly Linear Hydrogen Detection up to 10% Using Fully Suspended Pure Pd Nanowire). (Impact Factor: 18.087). ( https://pubs.acs.org/doi/10.1021/acsnano.3c06806?fig=fig1&ref=pdf )
The research was conducted through support from the National Research Foundation of Korea's Nano and Materials Technology Development Project and support and joint development efforts from Hyundai Motor Company's Basic Materials Research Center.
2024.01.25 View 3088