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Plasma, an Excellent Sterilizer to Remove Harmful Bacteria
(PhD candidate Joo Young Park, Professor Wonho Choe and PhD researcher Sanghoo Park)
KAIST researchers are using plasma to remove bacteria that are stuck to surfaces of plastic bottles and food. This novel technology will contribute to disinfection in medical settings as well as food and agricultural industries.
Professor Wonho Choe and his team from the Department of Physics developed a technology that removes biofilm, which is comprised of microorganisms, by using plasma as a non-thermal sterilization method.
Plasma contains multiple bactericidal agents, including reactive species. In particular, the chemicals formed in aqueous solution during plasma exposure have the potential for high antibacterial activity against various bacterial infections.
The team treated water with plasma to see how effectively bactericidal agents in the plasma water can remove biofilm comprised of harmful microorganism such as Escherichia coli, Salmonella, and Listeria.
The team identified that reactive species, including hydroxyl radical, hydrogen peroxide, ozone, nitrite, and superoxide produced during plasma treatment, showed considerable ability to remove the biofilm. Hydrogen peroxide showed the strongest effect removing the biofilm; however, the hydroxyl radical also played a significant role in removing biofilm. Despite having a concentration 100 to 10,000 times lower than other reactive species, the hydroxyl radical showed a high biofilm removal efficacy owing to its strong oxidative power.
These findings reveal that plasma can be used as a no-residual and safe sterilization process alternative to conventional methods. With these outcomes, the team is planning to develop and commercialize a technology that can produce hydroxyl radicals with plasma.
Professor Choe has registered a patent for flexible packaging materials that facilitate plasma and completed the technology transfer to the startup company, named ‘Plasmapp’, which focuses on commercializing bactericidal technology.
“This research outcome will be the foundation for understanding plasma control technology and physicochemical interactions between plasma and microorganisms. It will also become an accelerator for utilizing plasma technology in the medical, food, and agricultural fields,” said Professor Choe.
This research, led by PhD candidate Joo Young Park and PhD researcher Sanghoo Park in collaboration with Professor Cheorun Jo’s team from Seoul National University, was published in ACS Applied Materials and Interfaces on December 20, 2017.
Figure 1. Flexible packaging materials that facilitate plasma
Figure 2. Schematic diagram of biofilm treatment with plasma
Figure 3. Concept of plasma application and evaluation result of reactive species' efficacy
Figure 4. STERPACK, the product launched by Plasmapp
2018.01.25 View 9570 -
Cellular Mechanism for Severe Viral Hepatitis Identified
(Professor Shin(left) and Professor Jung)
KAIST medical scientists identified a cellular mechanism causing inflammatory changes in regulatory T cells that can lead to severe viral hepatitis. Research on this mechanism will help further understand the nature of various inflammatory diseases and lead to the development of relevant clinical treatments.
It is known that activated immune cells of patients with viral hepatitis destroy hepatocyte, but its regulatory mechanism has not yet been described.
Regulatory T cells inhibit activation of other immune cells and thus are important for homeostasis of the immune system. However, recent studies contradictorily show that immune inhibitory functions of regulatory T cells weaken in inflammatory conditions and the cells secrete inflammatory cytokines in response. Meanwhile, such a phenomenon was not observed in viral hepatitis including types A, B and C.
The team focused on changes in regulatory T cells in patients with viral hepatitis and discovered that regulatory T cells undergo inflammatory changes to secrete inflammatory cytokines (protein secreted by immune cells) called TNF. They also proved regulatory T cells that secrete TNF contribute to the progression of viral hepatitis.
The team confirmed that regulatory T cells of acute hepatitis A patients have reduced immune-inhibitory functions. Instead, their regulatory T cells secrete TNF. Through this research, the team identified a molecular mechanism for changes in regulatory T cells and identified the transcription factor regulating the process. Furthermore, the team found similar changes to be also present in hepatitis B and C patients.
A KAIST immunology research team led by Professors Eui-Cheol Shin and Min Kyung Jung at the Graduate School of Medical Science & Engineering conducted this translational research with teams from Chungnam National University and Yonsei University to identify the mechanism in humans, instead of using animal models. The research was described in Gastroenterology last December.
Professor Shin said, “This is the first research on regulatory T cells that contributes to hepatocyte damage in viral hepatitis.” He continued, “It is significant for identifying the cells and the molecules that can be used as effective treatment targets for viral hepatitis in the future. This research was funded by the Samsung Science and Technology Foundation.
(Figure1: Treg cells from acute hepatitis A (AHA) patients produce tumor necrosis factor (TNF) andhave reduced suppressive activity. These changes are due to a decrease in FoxP3 transcription factor and an increase in RORγt transcription factor. TNF-producing Treg cells are associated with severe liver injury in AHA patients.)
(Figure 2: A higher proportion of Treg cells from patients with acute hepatitis A, compared with healthy controls, produced TNF upon stimulation with anti-CD3 and anti-CD2. This study reports the presence and the significance of TNF-producing Treg cells for the first time in human patients.)
2018.01.18 View 8429 -
Three Professors Named KAST Fellows
(Professor Dan Keun Sung at the center)
(Professor Y.H. Cho at the center)
(Professor K.H. Cho at the center)
The Korean Academy of Science and Technology (KAST) inducted three KAIST professors as fellows at the New Year’s ceremony held at KAST on January 12. They were among the 24 newly elected fellows of the most distinguished academy in Korea. The new fellows are Professor Dan Keun Sung of the School of Electrical Engineering, Professor Kwang-Hyun Cho of the Department of Bio and Brain Engineering, and Professor Yong-Hoon Cho of the Department of Physics.
Professor Sung was recognized for his lifetime academic achievements in fields related with network protocols and energy ICT. He also played a crucial role in launching the Korean satellites KITSAT-1,2,3 and the establishment of the Satellite Technology Research Center at KAIST.
Professor Y.H.Cho has been a pioneer in the field of low-dimensional semiconductor-powered quantum photonics that enables quantum optical research in solid state. He has been recognized as a renowned scholar in this field internationally.
Professor K.H.Cho has conducted original research that combines IT and BT in systems biology and has applied novel technologies of electronic modeling and computer simulation analysis for investigating complex life sciences. Professor Cho, who is in his 40s, is the youngest fellow among the newly inducted fellows.
2018.01.16 View 13741 -
Harnessing the Strength of KAIST Alumni: New Head of KAA Inaugurated
KAIST alumni gathered in Seoul on January 13 to celebrate the New Year and the newly-elected leadership of the KAIST Alumni Association (KAA). More than 300 alumni, including President Sung-Chul Shin who is also an alumnus of KAIST, joined the gala event held at the Lotte Hotel.
Photo: Ki-Chul Cha(left) and Jung Sik Koh(right)
The KAA inaugurated its new president, Ki-Chul Cha, who was preceded by Jung Sik Koh, the former CEO at the Korea Resources Corporation. His term starts from January 2018 to December 2020.
Cha is the CEO of Inbody Co Ltd., a global company specializing in developing and selling medical instruments, such as a body composition analyzers, and medical solutions. He is also an adjunct professor in the Department of Mechanical Engineering at Yonsei University. Cha obtained a master’s degree in Mechanical Engineering at KAIST in 1980, and a Ph.D. in Bioengineering at the University of Utah, before finishing his post-doc fellowship at Harvard Medical School.
Cha plans to explore the idea that alumni engagement, saying, “KAIST stays as a home in the memories of 60,000 alumni. I will dedicate myself to stimulating the alumni association to make KAISTians proud.”
At the gala event, the KAA awarded the Alumni of the Year honor to six alumni who distinguished themselves in the areas of professional achievement, humanitarianism, and public service. They are the Director of Startup KAIST Professor Byoung Yoon Kim; President of LG Chem Ltd and Head of Battery Research and Development Myung Hwan Kim; Director of INNOX Advanced Materials Co., Ltd Kyung Ho Chang; Vice President of the Korea International Trade Association Jung-Kwan Kim; CEO of Samsung Electro-Mechanics Yun-Tae Lee; and CEO of ENF Technology Jinbae Jung.
Photo: President Shin(far right) poses with six awardees of the Distinguished Alumni Award and the former President of KAA, Koh(far left)
2018.01.16 View 10408 -
One-Step Production of Aromatic Polyesters by E. coli Strains
KAIST systems metabolic engineers defined a novel strategy for microbial aromatic polyesters production fused with synthetic biology from renewable biomass. The team of Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering produced aromatic polyesters from Escherichia coli (E. coli) strains by applying microbial fermentation, employing direct microbial fermentation from renewable feedstock carbohydrates.
This is the first report to determine a platform strain of engineered E. coli capable of producing environmentally friendly aromatic polyesters. This engineered E. coli strain, if desired, has the potential to be used as a platform strain capable of producing various high-valued aromatic polyesters from renewable biomass. This research was published in Nature Communications on January 8.
Conventionally, aromatic polyesters boast solid strength and heat stability so that there has been a great deal of interest in fermentative production of aromatic polyesters from renewable non-food biomass, but without success.
However, aromatic polyesters are only made by feeding the cells with corresponding aromatic monomers as substrates, and have not been produced by direct fermentation from renewable feedstock carbohydrates such as glucose.
To address this issue, the team prescribed the detailed procedure for aromatic polyester production through identifying CoA-transferase that activates phenylalkanoates into their corresponding CoA derivatives. In this process, researchers employed metabolic engineering of E. coli to produce phenylalkanoates from glucose based on genome-scale metabolic flux analysis. In particular, the KAIST team made a modulation of gene expression to produce various aromatic polyesters having different monomer fractions.
The research team successfully produced aromatic polyesters, a non-natural polymer using the strategy that combines systems metabolic engineering and synthetic biology. They succeeded in biosynthesis of various kinds of aromatic polyesters through the system, thus proving the technical excellence of the environmentally friendly biosynthetic system of this research. Furthermore, his team also proved the potential of expanding the range of aromatic polyesters from renewable resources, which is expected to play an important role in the bio-plastic industry.
Professor Lee said, “An eco-friendly and sustainable chemical industry is the key global agenda every nation faces. We are making a research focus to a biochemical industry free from petroleum dependence, and conducting diverse research activities to address the issue. This novel technology we are presenting will serve as an opportunity to advance the biochemical industry moving forward.”
This work was supported by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) and also by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012M1A2A2026556 and NRF-2012M1A2A2026557) from the Ministry of Science and ICT through the National Research Foundation of Korea.
Figure: Biosynthesis of aromatic polyesters by metabolically engineered E. coli.This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced aromatic polyesters from glucose.
2018.01.09 View 7362 -
President Shin Reaffirms Innovation Initiatives in New Year Speech
(President Shin and representatives of faculty, students, staff celebrate the New Year in a reception held on January 2 at the auditorium.)
The KAIST community gathered to celebrate a fresh start for the year 2018. At the ceremony, held in the auditorium on January 2, members of KAIST community reaffirmed their commitment to be the trailblazers of Korea and beyond through unwavering innovations.
President Sung-Chul Shin presented his new vision and plan in his New Year speech, which focused on innovation for enhancing institutional competitiveness and global visibility. He said that as you are the future of KAIST, KAIST is the future of Korea. KAIST’s vision for a better future will have a significant impact on national progress and beyond. He stressed that innovation in the five pillars of education, research, technology commercialization, globalization, and future strategy will further advance the excellence of KAIST.
At the ceremony, President Shin also presented the award for ‘the KAISTian of the Year’ to Professor YongKeun Park of the Department of Physics. The annual award recognizes a distinguished professor whose academic accomplishments made the most significant impact.
In his New Year speech, President Shin said that the year 2018 will provide an opportunity to take a leap forward for becoming a ‘Global Value Creative, World-Leading University. The Vision 2031 Committee endorsed the five innovation initiatives to fulfill KAIST’s long-term vision and will open its recommendations to the public on March 20.
Educational innovation tops the initiatives. President Shin explained that the future of Korea is in the hands of talented individuals in science and technology, emphasizing the need to nurture creative, transdisciplinary talents with the capacity to enhance the social value of science and technology.
To this end, KAIST will establish a new undergraduate non-departmental program for transdisciplinary education. This plan will eventually provide students with more options in choosing their major, as well as help students build a strong foundation in basic science and engineering and encourage multidisciplinary approaches.
For creating an innovative institutional research infrastructure, KAIST plans to build a Network of Excellence for the Fourth Industrial Revolution (NExFire) for convergence research. The plan of ‘Cross-Generational Collaborative Labs,’ will bring out a new collaboration platform by pairing up senior and junior faculty. President Shin said it will be a stepping stone to extend the spectrum of knowledge without any cessation.
For technology commercialization, KAIST will maximize its intellectual property and economic value by stimulating technology-invested companies and startups. Close cooperation with venture capitalists at home and abroad will further accelerate the commercialization drive at KAIST.
Saying that the globalization is no long an option but a necessity, he stressed KAIST will strengthen its efforts to established a bilingual campus. “KAIST will make every effort to create a more welcoming and comfortable atmosphere for the international community and their families. We will expand benefits to our international community, such as access to the KAIST Child Care Center and collaboration with the Taejon Christian International School (TCIS),” he said. President Shin added he will further expand global networks and partnerships this year, participating in a diverse range of international events at home and abroad for increasing global visibility.
He also said that well-designed future strategies will complete innovation initiatives. The Future Strategy Research Center will serve as a think tank for identifying future agendas, establishing strategies and advocating for them.
In addition to the five innovation initiatives, President Shin emphasized a new organizational culture that embraces inclusiveness and mutual respect among all of the members of KAIST.
“So far, the ideal qualifications expected of KAISTians have included creativity and a challenging spirit. From now on, we will nurture talents with a focus on the 3Cs: Creativity, Challenge, and Caring. I would like to make a campus in which all members care for each other to help attain mutual growth with warmth and respect," he said.
For the full text, Click
2018.01.02 View 8985 -
Distinguished Professor Sang Yup Lee Named NAI Fellow
(Distinguished Professor Sang Yup Lee)
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering was named to the National Academy of Inventors in the US. He is the first Korean scholar ever elected as a NAI fellow.
The NAI is a non-profit member organization with over 4,000 individual inventors and fellows spanning more than 250 institutions worldwide. It is comprised of universities as well as governmental and non-profit research institutes. The academy was founded in 2010 to recognize and encourage inventors with patents from the US Patent and Trademark Office. So far, 575 fellows from 229 institutions have been elected.
The academy said Professor Lee has been recognized for fellowship induction as he has demonstrated a highly prolific spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on quality of life, economic development, and the welfare of society.
Distinguished Professor Lee, a pioneering researcher and scholar in the field of systems metabolic engineering, was ranked in the top 1% of highly cited researchers (HCR) this year. Over the past 11 years, he published more than 130,000 articles in prestigious journals around the world. He has been cited more than 34,000 times since he started working at KAIST in 1994.
He is also the first Korean ever elected to both the National Academy of Sciences (NAS) and the National Academy of Engineering (NAE) in the US, becoming the one of 13 foreign scholars in the world holding two prestigious institutions’ fellowships.
Dr. Lee is currently the dean of KAIST Institutes, the world-leading institute for multi and interdisciplinary research. He is also serving as co-chair of the Global Council on Biotechnology and is a member of the Global Future Council on the Fourth Industrial Revolution at the World Economic Forum.
2017.12.13 View 8500 -
CLKIP Bearing Fruit in China
The Chongqing Liangjiang KAIST International Program (CLKIP) is rapidly gaining steam in China. CLKIP, an educational program operated in Chongqing internationally by KAIST since 2015, offers two majors, Electronic Information Engineering and Computer Science and Technology, applying the same curriculum as at KAIST.
To operate the program, KAIST assigns professors from the School of Electrical Engineering and the School of Computing to the program every year. They are in charge of one-third of the major courses, and transfer KAIST’s educational curriculum and know-how.
A total of 13 professors from Chongqing University of Technology (CQUT) have received or are receiving training on advanced education methodologies and technical know-how, including an on and offline integrated learning program, called Education 4.0 and large-scale internet open learning.As CLKIP is gaining in popularity, the number of students for its undergraduate courses keeps increasing, from 66 in 2015 to 172 in 2016 and 200 students in 2017, achieving the student volume for enrollment annually.
CLKIP selected seven exchange undergraduate students and five dual-degree students this fall, and they are currently studying in KAIST for either one semester or one full year.
CLKIP is located in Chongqing, one of the major direct-controlled municipalities and a focal point for notable government projects. The Korea-China industrial zone is also located in this area.
Considering its location, CLKIP is more than just an international programs for educational cooperation. The program will provide opportunities to cooperate with Korean enterprises including Hyundai, SK Hynix, LG Chem and Hankook Tire. While cooperating in research and development as well as technical assistance, KAIST hopes that these enterprises will play a bridging role for KAIST alumni entering the Chinese market.
President Sung-Chul Shin said, “The success of CLKIP shows that KAIST programs for fostering future manpower and developing cutting-edge technologies do work in other countries. Based on this case, KAST will put more effort into transferring our innovative education systems abroad. We are also pushing ahead to establish a joint institute between KAIST and CQUT by 2018, which will become a foundation for facilitating the entry of KAIST’s cutting-edge technologies into the Chinese market.”
“KAIST aims to become an entrepreneurial university that creates value through technology commercialization. In this sense, KAIST plans to transfer advanced technologies to domestic and international companies located in the Liangjiang district,” he added.
2017.12.12 View 10792 -
Hubo Completes New Mission at the Winter Olympic Torch Relay
KAIST-born humanoid robot, Hubo, completed its special new mission: carrying the Olympic torch. The Winter Olympics will be held in PyeongChang for two weeks beginning February 9.
On December 11, the final leg of the torch relay in Daejeon for the PyeongChang Olympics 2018 took place inside KAIST. A city known for science and technology hosted special torch relay runners over three days.
Hubo arrived at the campus with Dr. Dennis Hong, a professor from the University of California at Los Angeles, in an autonomous vehicle. Then, Hubo received the flame from Professor Hong. Hubo, a robot developed by Professor Jun Ho Oh from the Department of Mechanical Engineering at KAIST, is best known for being the winner of the DARPA Robotics Challenge in 2015.
Hubo successfully completed its Olympic mission. That is, it had to drill through a wall to deliver the torch to the next runner. After completing the mission successfully, the torch was passed to Professor Oh. He ran a few steps and handed it over to the last runner of the Daejeon leg.
The last runner was Jung Jae Lee, who is a winning team member of the Samsung Junior Software Cup. Lee also had the honor of riding and controlling FX-2 which is another robot developed by Professor Oh for this peace torch relay. FX-2 took a few steps to finalize the relay.
Lee said, “I would like to become an expert in security. As I was riding the robot, I felt every step I took was one step closer to achieving of making major developments in the field of security.
Professor Oh said, “It is meaningful to see humans and robots cooperating with each other to carry out the torch relay.”
The torch relay, participated in by both humans and robots in Daejeon, was successfully completed and the torch headed off to Boryeong, Chungcheongnam-do.
2017.12.12 View 10219 -
MoU by KAIST-Seoul-Seocho-gu for the 4th Industrial Revolution
The opening ceremony of the Yangjae R&CD Innovation Hub was held in Seoul on December 5. More than 400 guests came to the ceremony from major institutes and companies that are based in the hub. KAIST President Sung-Chul Shin, the Mayor of Seoul, Won-soon Park, and the Mayor of Seocho-gu, Eun Hee Cho, signed an MoU for Seoul to be the leading city for successfully realizing the Fourth Industrial Revolution.
The three organizations aim to cooperate with one another in various areas, including an economic boost for local job creation, technology development, and the promotion of projects through an industry-academia-institute network and fostering manpower.
Yangjae R&CD is the first facility specializing in and dedicated for Artificial Intelligence, which is the major topic of the Fourth Industrial Revolution.
The hub is comprised of enterprises specializing in AI, open co-work spaces, conference rooms, an open networking lounge, and spaces for fostering professional manpower. The hub will recruit additional enterprises and individuals who wish to move in. KAIST, an institute containing professors and researchers in the field of AI, and Modulabs, an organization becoming distinguished in AI research, will be in charge of operating the facility together.
The Yangjae R&CD Innovation Hub will operate a professional training program with participation from KAIST professors, which aims to produce 500 professionals in AI research and development by 2020. It will also provide inexpensive space as well as consultations and venture capital to startup and venture companies. It plans to find and foster 50 innovation companies by 2020.
In particular, the hub will operate a course for new AI business models 24 times over three years.
The hub also offers job consultations, academic conferences, public space for companies residing in the hub, a free GPU cluster server, technical training, seminars, forums, investment attraction, overseas expansion, and one-to-one technical consultations.
The Yangjae R&CD Zone is the place established for the Fourth Industrial Revolution by Seoul. R&CD is a concept combining Research and Development, Connection, Companies, Community, and Culture.
Seoul aims to create the Yangjae Zone as an urban innovation hub for facilitating industry-academia linkage as well as establishing a startup-settlement-growth technical ecosystem.
2017.12.11 View 9430 -
KAIST International Community Celebrates the Year-End
KAIST international community all gathered in celebration of the year-end on December 5 at the KAIST auditorium. This year, the community made the year-end party very special, expressing their appreciation very touching way at the event hosted by the International Scholar and Student Services (ISSS). Nearly 650 international faculty, students, and their family members joined the party.
Currently, 184 faculty members and researchers from 29 countries are working at KAIST, with 901 international students from 92 countries enrolled.
The two-hour party offered them a chance to enjoy a wide variety of activities and events, including dance performances, student performances, games, and dinner.
The party also had a meaningful award ceremony. Prior to the event, a month-long survey was conducted, asking international scholars and students which on-campus team they were most thankful for this year. Candidates for the appreciation award were: Safety and Security Team, Student Affairs Team, Campus Police, dormitory supervisors, and campus cleaning staff.
Approximately 470 scholars and students responded to the survey and 214 voted for the campus cleaning staff (45.5%).
(President Sung-Chul Shin and Myeongja Kim)
Ms. Myeongja Kim, a director of the cleaning staff in the undergraduate zone, received the award on behalf of the entire cleaning staff. At the ceremony, President Sung-Chul Shin conferred the award.
President Shin in his welcoming remarks said that globalization is his priority and urgent mission. To make KAIST more globalized, he said he will focus on three agendas; to make the campus KAIST a more welcoming environment for international community; to make campus more inclusive and diverse; to enhance the global visibility of KAIST more proactively. Click for the full text of opening remarks
2017.12.11 View 5704 -
A New Spin Current Generating Material Developed
(Professor Park(left) and Ph.D. candidate Kim)
Magnetic random-access memory (MRAM) is a non-volatile device made of thin magnetic film that can maintain information without an external power supply, in contrast to conventional silicon-based semiconductor memory. It also has the potential for high-density integration and high-speed operation.
The operation of MRAM involves the control of the magnetization direction by exerting spin current-induced torque on a magnetic material. Spin current is generated using electricity in conventional MRAM, but this study developed materials technology that generates spin current using heat.
A KAIST research team led by Professor Byong-Guk Park of the Department of Materials Science and Engineering developed a material that generates spin current from heat, which can be utilized for a new operation principle for MRAM.
There have been theoretical reports on the spin Nernst effect, the phenomenon of the thermal generation of spin current, but is yet to have been experimentally proven due to technological limitations. However, the research team introduced a spin Nernst magnetoresistance measurement method using tungsten (W) and platinum (Pt) with high spin orbit coupling which allows for the experimental identification of the spin Nernst effect. They also demonstrated that the efficiency of spin current generation from heat is similar to that of spin current generated from electricity.
Professor Park said, “This research has great significance in experimentally proving spin current generation from heat, a new physical phenomenon. We aim to develop the technology as a new operational method for MRAM through further research. This can lower power consumption, and is expected to contribute to the advancement of electronics requiring low power requirement such as wearable, mobile, and IOT devices”.
This research was conducted as a joint research project with Professor Kyung-Jin Lee at Korea University and Professor Jong-Ryul Jeong at Chungnam National University. It was published in Nature Communications online on November 9 titled “Observation of transverse spin Nernst magnetoresistance induced by thermal spin current in ferromagnet/non-magnet bilayers.” Ph.D. candidate Dong-Jun Kim at KAIST is the first author. This research was funded by the Ministry of Science and ICT.
(Schematic diagram of spin Nernst magnetoresistance)
(Research result of new spin current generating materials)
2017.12.08 View 8195