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Information on the notification of student numbers for undergraduate freshmen of spring semester 2007 and input of personal information
Information on the notification of student numbers for undergraduate freshmen of spring semester 2007 and input of personal information
Freshmen are asked to input personal information from November 13 (Mon) thru 24 (Fri).
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2006.11.14 View 10663 -
Professor Sang-Yup Lee publishes a requested paper in Nature Biotechnology
Professor Sang-Yup Lee publishes a requested paper in Nature Biotechnology
“The era of commercialized bioplastic is coming”
Disclose an opinion as specialist at a requested paper in Nature Biotechnology, October 2006
A team led by Barbel Friedrich, Professor of Humboldt-Universitat zu Berlin, and Alexander Steinbuchel, Professor of West falische Wilhelms-Universitat Munster, found out the entire genome sequence of the typical bioplastic-producing microorganism ‘Ralstonia eutropha’ and published a paper on it in Nature Biotechnology, October 2006. As the entire genome sequence of the typical bioplactic-producing microorganism has been discovered, it is expected that the efficient production of bioplastic will be available through strain improvement at a more systematic level.
Regarding this paper, Nature Biotechnology requested world-renowned scholar Sang-Yup Lee, LG Chemical Chair-Professor of KAIST Chemical and Biomolecular Engineering Department, an expert analysis on the future of bioplastic production as a result of the deciphering of the genome sequence, and Professor Lee revealed his opinion at ‘News and Views’ in Nature Biotechnology, October 2006, issued on October 10. In the analysis, he insisted, “The deciphering of the genomes of Ralstonia means to pave the way for the improvement of strains at a system level by combining simulation through various omics and imaginary cells and engineering at a genome level. It will be possible to produce plastic with desired properties by altering the components of plastic as desired and produce bioplastic, more efficient and economical than have been reported so far, through the optimization of metabolic flow.”
Professor Lee is a world-renowned scholar in the bioplastic field, who has presented about 70 SCI papers in the field. He created a word ‘Plastic Bacteria’ at Trends in Biotechnology in 1996 and published an expert paper regarding E.Coli Plastic at Nature Biotechnology in 1997. He is now performing a research concerning the improvement of bioplastic-producing strains as an example of a research employing a systematic method for the system biological research and development project of the Ministry of Science and Technology.
The followings are the contents of Professor Lee’s paper concerning microorganism plastic published at ‘News and Views’ in Nature Biotechnology, October 2006.
- Polyhydroxyalkanoate (PHA) is a high molecule that numerous microorganisms accumulate in their own cells as energy storage substance when they are rich in carbonic resources, but poor in the other growth factors. The PHA high molecule is polyester, in which the unit substances (unit chemicals) are ester-bonded, and has been studied worldwide about twenty years before. However, PHA’s worse properties than petrochemical plastic and extremely high production cost have prevented its commercialization. The production cost of PHA was 15 dollars per kg in 1980’s, twenty times higher than the price of polypropylene. Sang-Yup Lee, LG Chemical Chair-Professor of KAIST Chemical & Biomolecular Department’s BK21 Project Group, has performed a research concerning the efficient production of microorganism plastic through the combination of metabolic engineering and fermentation process under the support of the Ministry of Science and Technology, and developed a process that lowers the production cost of PHA to 2-3 dollars per kg. He also has developed PHA-producing bacteria, efficient enough to fill plastic tightly, and named it ‘Plastic Bacteria’.
- The unprecedented rise of oil price for the past two years activated the researches on Bio-based energies and chemical production globally. PHA is also regaining attentions although the researches on it have been withered so far due to its poor economical efficiency and properties. The result of the genome deciphering of the typical plastic-producing microorganism ‘Ralstonia eutropha’ published by a German research team in Nature Biotechnology, October 2006 suggests huge meanings. That is, it will provide a blueprint over the metabolic activities of the bacteria and thus enables more systematic strain improvement.
- Eyeing on these facts, Nature Biotechnology requested Professor Sang-Yup Lee an expert analysis, and Professor Lee analyzed that there would be a dramatic development of microorganism plastic production through the application of the system biological engineering method, which is now being performed actively by Professor Lee at KAIST. In the analysis, Professor Lee revealed, “As the genome sequence has been found out, it becomes possible to establish metabolic network at a genome level, and since simulation becomes available, numberless trial and errors and experiments can be replaced with imaginary experiments rapidly. In addition, It makes the more efficient development of strains possible by fusion-analyzing the omics result such as various transcripts, proteins, metabolites, etc.” He also expected that it would be possible to produce tailor-made PHA having desired properties through metabolic engineering as well as the efficient production of plastic. Besides, he prospected that his research on the production of optically pure hydroxyl carboxyl acid, Professor Lee’s international patent right, would gain driving forces and technical development would be made rapidly at biological hydrogen production, production, dissolution and application of aromatic compounds, etc. by featuring this strain.
- Recently, Metabolic and ADM, U.S. companies, jointly started to produce PHA at a commercialization level, and Brazil having rich natural resources is commercializing PHA, following Bio-ethanol. In addition, Japan and Germany having a bunch of research performance in this field, and Australia having rich biomass are also performing consistent researches on PHA’s commercialization. Professor Lee prospected, “With the finding out of the genome sequence of the typical bioplastic-producing microorganism, competition for commercialization will be fiercer among nations through the development of efficient production systems.”
- Professor Lee prospected that as the efficient production of PHA becomes possible, the production of plastic from various renewable ingredients (cellurose, starch, suger, etc.) through microorganism fermentation would be made practically and the white biotechnologies of existing chemicals would gain more power. He also said, “Korea also will have to try to secure the production technologies and industry of Bio-based chemicals through strategic cooperation with resource powerfuls, etc. on the basis of the technical dominancy in some system metabolic engineering fields.”
- ‘News and Views’ in Nature Biotechnology is a section that publishes analyses of world-renowned specialists in the corresponding fields over the contents of some papers having great influences among papers published in the issue. KAIST Professor Sang-Yup Lee has published his second expert analysis of ‘Deciphering bioplastic production’ in the volume of October 2006, following the first paper ‘Going into the era of E.Coli plastic’.
2006.10.23 View 15267
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H.Y.Choi won BSPA
H.Y.Choi won BSPA
Hyun-Young Choi, Doctor’s course at the Lightwave Systems Research Laboratory (LSRL) of Department of Electrical Engineering of KAIST (Professor in charge Yoonchul Jung), won the Best Student Paper Awards (BSPA) in the Asia-Pacific Optical Communications 2006.
BSPA is awarded to the most prospective paper in the field of Optical Transmission, Switching, and Subsystems. Choi suggested an OSNR monitoring technique among performance monitoring techniques for the efficient maintenance and management of optical network in her paper. Her technique is based on a polarization-nulling method using the polarization features of optical signals. It employs polarization mode dispersion compensator and acousto optic tunable filter (AOTF) to prevent monitoring errors arising from polarization mode dispersion (PMD) and non-linear double refraction, which considerably improves the monitoring technique and makes it possible to demonstrate a technique proposed at ultra long haul network.
2006.10.16 View 13513
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Notification of student numbers and input of personal information for freshmen of the first master's, doctor's, and unified course 2007
Notification of student numbers and input of personal information for freshmen of the first master’s, doctor’s, and unified course 2007
Notification of student numbers and input of personal information for freshmen of the first master’s, doctor’s, and unified course 2007
Enrolled students are requested to input personal information.
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2006.10.10 View 11757
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Sona Kwak wins first prize in international robot design contest
Sona Kwak wins first prize in international robot design contest
Sona Kwak (Doctor’s course, Department of Industrial Design) won the first prize in an international robot design contest.
Kwak exhibited an emotional robot of ‘Hamie’ at ‘Robot Design Contest for Students’ in Ro-Man 2006/ The 15th IEEE International Symposium on Robot and Human Interactive Communication, which was held at University of Hertfordshire, United Kingdom for three days from September 6 (Wed) and obtained the glory of the first prize.
‘Hamie’, the work of the first prize, has been devised in terms of emotional communication among human beings. The design concept of ‘Hamie’ is a portable emotional robot that can convey even ‘intimacy’ using senses of seeing, hearing, and touching beyond a simple communication function. The design of ‘Hamie’ was estimated to best coincide with the topic of the contest in consideration of its function that allows emotional mutual action between human beings as well as mutual action between human and robot, or robot and robot. ‘Hamie’ is not an actual embodiment but proposed as ‘a concept and design of a robot’.
‘Ro-man’ is a world-famous academic conference in the research field of mutual action between robot and human being, and ‘Robot Design Contest for Students’ is a contest to scout for creative and artistic ideas on the design and structure of future robots and exhibits works from all over world.
Kwak is now seeking to develop the contents and designs of various next-generation service robots such as ▲ ottoro ? cleaning robot ▲ robot for blind ▲ robot for the old ▲ robot for education assistance ▲ robot for office affairs ▲ ubiquitos robot in her lab (PES Design Lab) led by Professor Myungseok Kim.
“I’ve considered and been disappointed about the role of designers in robot engineering while I’ve been designing robots. I am very proud that my robot design has been recognized in an academic conference of world-famous robot engineers and gained confidence,” Kwak said.
2006.09.27 View 15480
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Professor Eunjoon Kim's team finds synapse-forming protein
Professor Eunjoon Kim’s team finds synapse-forming protein
- discover a new protein ‘NGL’ that promotes the formation of neuronal synapses
- can presume the cause of various brain disorders including schizophrenia
- will be published at Nature Neuroscience Vol. 9 in September
A new protein that promotes the formation of synapses in human brains was discovered by a Korean research team.
The team led by Eunjoon Kim, Professor of Department of Biological Sciences and Head of Creative Research Group of Synapse Formation), announced that it had discovered a new fact that NGL protein promotes the formation of neuronal synapses and this fact would be published in Nature Neuroscience Vol. 9 on September 18.
Professor Kim’s team discovered that a membrane protein named ‘NGL’ located at post synapse links with other membrane protein named netrin-G in pre synapse, acting as crosslink, and promotes the formation of a new synapse.
‘NGL’ is the second protein found to crosslink synapse, following neuoroligin. With the discovery of this new protein, the principle of synapse formation and the causes of various brain disorders can be presumed.
In the human brain, about more than 100 billion neuron cells and about 10,000 synapses compose neural circuit. A synapse is the place where innervation occurs between neuron cells. The formation of synapse induces the formation of neural circuit, and neural circuit is deeply related with various brain disorders as well as normal development of brains or brain functions.
“As netrin-G linked with NGL is related with schizonphrenia and neuoroligin and synapse crosslinking protein having a similar function with NGL is deeply related with mental retardation and autism, I think NGL is related with various brain disorders including schizophrenia.”
<Explanation of attached photos>
■ Photo1: Experiment for confirming NGL’s ability to form synapse No. 1
Mix ordinary cell (green) revealing NGL at its surface and neuron cell. Axon grows toward NGL (ordinary cell) located in the middle of ten o’clock direction and meets NGL, where NGL induces the formation of pre synapse (red) in the contacting axon.
Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named Synapsin.
- Figure a-b: formation of synapse by NGL
- Figure c-d: transformed NGL losing synapse forming ability cannot form synapse
■ Photo 2: Experiment for confirming NGL’s ability to form synapse No. 2
When beads coated with NGL are scattered on neuron cell, the beads contact with the axon of the neuron cell (the beads are clearly visible at the phase differentiation image in the middle panel). At this time, NGL induces the formation of pre synapse (red) in the axon. Whether pre synapse has been formed can be told by the fluorescent dying (red) of pre synapse protein named SynPhy (panel a) or VGlut1 (panel b).
2006.09.21 View 14927
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Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park awarded Minister Prize
Professor Tae-Gwan Park (Department of Biological Sciences) was awarded the Minister Prize in the science innovation sector at the NANO KOREA 2006, which was opened on August 30.
This prize is given to researchers who have shown excellent research results in the field of Nanotechnology, and Professor Park was awarded the Minister Prize in recognition of his innovative achievements in the fields of Tissue Engineering, Drug Delivery, Gene Therapy, which are fusion technologies of NT and BT that utilize nanobiomaterials.
2006.09.06 View 14216
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Professor Chan Beum Park, requested for joint international research by a German biotechnology enterprise.
- Bitop AG (Germany) requested a joint development of medicines for Alzheimer’s disease
- The meaning of the financial support by European enterprise to the research result of domestic university.
Professor Chan Beum Park (Department of Materials Science and Engineering in KAIST/ President Nam Pyo Suh) has been entrusted with a joint international research for the development of medicines for Alzheimer’s disease from Bitop AG, German biotechnology enterprise.
KAIST recently agreed with Bitop AG to cooperate for a research program pursuing the development of inhibitors that inhibit the formation of plaque relevant to amyloid diseases like Alzheimer’s disease. Based on this agreement, KAIST will be provided with a financial support of sixty thousands Euro (about 74 million won) from Bitop AG.
Professor Park will perform the screening of inhibitors, which are the core of the research, and KAIST will share patent rights from the research with Bitop AG.
It is known that various degenerative nerve diseases like Alzheimer’s disease, Parkinson’s disease, mad cow disease, and so on arise mainly from the accumulation of pathological protein plaque termed amyloid, and environmental stress accelerates the diseases.
So far, no effective remedy has been developed for amyloid diseases.
Recently, the use of chemicals inhibiting the formation of amyloid has been raised as a potential remedy.
Natural small stress molecules extracted from microbes growing in extreme environments like volcanic region on the bottom of the deep sea, etc. are gaining attention as an amyloid inhibitor.
Professor Park found out for the first time in the world that Anti-stress materials are effective in inhibiting the formation of amyloid plaque and published that fact in several renowned European scientific journals.
After that, Professor Park was requested by Bitop AG for a joint research and has studied for the development of medicines for Alzheimer’s disease using various kinds of Anti-stress materials.
Professor Park said, “I’d like to grant a highly valuable meaning to this entrustment since it implies that European enterprises perceive the value of the research result by domestic universities and hope to promote research and development by providing practical financial support, etc. I wish this time’s entrustment will be a momentum to advance Korea’s research level one step higher through active joint researches with enterprises or institutes in U.S. and Europe as well as Bitop AG.”
Bitop AG is a German enterprise that produces various Anti-stress materials coming from extreme-loving microbes.
Currently, Anti-stress materials are being sold mainly as protein and cell protectants, cosmetic additives, health supplement, etc.
Anti-stress materials extracted from microbes well growing in extreme environment of one hundred centigrade or more are expected to perform a role of inhibitors that inhibit the formation of amyloid plaque, the main factor of stress-related degenerative nerve diseases like Alzheimer’s disease, etc. Such Anti-stress materials are gaining attention as a future medicine for Alzheimer’s disease, etc.
2006.09.05 View 14084
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National NanoFab Center Established
NNFC Emerges with Cutting-edge Nanotech
On March 16, a dedication ceremony was held at KAIST to mark the completion of the National NanoFab Center(NNFC). The opening was graced with the presence of several prominent figures, namely, President Robert B. Laughlin, Daejeon City Mayor Hong-chul Yum, and Myung Oh, Deputy Prime Minister and Minister of Science and Technology.Celebrations of the opening were attended by roughly 300 related personnel. After a welcoming speech given by Hee-Chul Lee, President of NNFC, the event proceeded with a ribbon cutting ceremony, followed by a grand tour of the cleanroom.
The newly completed NNFC on campus boasts a total area of 17,035 square meters which consists of a four-storey research building, a cleanroom and a central utility building.
Still at the first stage of its equipment supplementation, the center has currently achieved an immense 140 in gear variety, worth approximately 80 billion won. At its final stage, a total of 206 equipment arrangements are to be available for various research purposes.
Implementing the use of state-of-the-art facilities, NNFC’s devices include an electron beam capable of critical measurements as small as ten nanometers and an ion beam structure for the analysis of nano-scale materials. These equipments are to be used in numerous areas - fundamental physics, biotechnology and nanoscience
Until the year 2011, a sum of 290 billion won is to be invested in the NNFC by the government and other private organizations. The center, along with Daedeok Techno Valley, aspires to play an integral role in maturing towards a new age of nanotechnology.
President Lee of the NNFC stated that the center is essential for Korea’s nanotechnology skills to achieve higher standards and compete with countries such as the U.S. and Japan. President Lee is also a professor of KAIST at the Division of Electrical Engineering.
By Kyoung-lee Park / Staff ReporterApril, 2005 / The KAIST Herald
2005.04.12 View 20011
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KAIST Develops Thinking, Feeling Human-Like Robot
By Kim Tae-gyu / Staff ReporterTHE KOREA TIMES 2005.1.31(page 1)
South Korean scientists created the world"s first artificial species, a software robot with ``genes"" and ``chromosomes.""
Kim Jong-hwan, professor at Korea Advanced Institute of Science and Technology, said Sunday his team had developed a robot with 14 chromosomes, which gives the machine a ``personality.""
``This robot is a software-based one, sometimes called a sobot. It has a unique synthetic character determined by its specific combination of 14 chromosomes,"" the 47-year-old Kim said.
When Kim"s team gave a stimulus to the chromosome-equipped sobots, they showed totally different responses even under the same environment due to their distinctive personalities.
Several cognitive sensors enable the prototype models to identify 47 differing outside stimuli. The virtual robots also have 77 behavior patterns.
``Because a sobot is basically a software system, it can easily travel to other robots and multiply. In the middle of such processes, it can evolve through crossover and mutation,"" Kim said.
With the development of associated technologies, Kim expected the number of chromosomes would be augmented as sobots evolve to a more sophisticated species in the future.
The capacity to load large volumes of data is related to the evolution of sobots. Currently, 14 chromosomes consist of roughly 2,000 bytes of data.
The effort to incorporate the sobot into a platform, robot hardware, is now underway and Kim"s team looks to unveil the new-concept species as soon as next month.
``Diverse behavior patterns driven by sobots" specific personalities will be precisely translated into action just like the soul rules the body,"" Kim said.
Kim did not think the robotic evolution would lead to the human race being threatened; the concept of the recent blockbuster ``I, Robot.""
``If we design the chromosomes safely, the self-reproducing robot will not post a threat back to us,"" Kim said.
Kim first revealed the robotic breakthrough at a keynote speech of the International Conference on Autonomous Robots and Agents, held in New Zealand last December.
Kim is also known as pioneer in the field of robot football and has headed the Federation of International Robot-soccer Association (FIRA) since its foundation in 1999.
voc200@koreatimes.co.kr
2005.02.02 View 15068
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Nerve-protecting gene discovered
Korean scientists for the first time have identified a gene that blocks nerve damage from fevers and the use of narcotics, a state-run research institute said yesterday.
The finding may open the way for new medicine that can prevent the loss of brain function which is frequently caused by excessive stimulation of nerves and abnormally high body temperature.
"The research is in an early stage. But this approach has the potential to develop genetics-based preventatives against brain-attacking diseases," said Kim Jae-seob, a bioscience professor of the Korea Advanced Institute of Science and Technology, who led the study.
The researchers named the gene Pyrexia, which means fever. Kim"s team extracted it from genetically engineered fruit flies using a genome-screening system. In laboratory tests, they found that the gene is activated to 39 degrees Celsius or higher.
The researchers enhanced Pyrexia"s functionality in some fruit flies while removing the gene from others to observe their different reactions when exposed to high temperature.
"The fruit flies without the gene showed severe nerve disorder and suffered paralysis of brain function, while Pyrexia-enhanced flies maintained their normal brain conditions," the professor said.
The researchers got the same result from experiments with human cells, he said.
There are a lot of channel proteins, which enable ions to enter and exit the cell, that react to the level of temperature, but Pyrexia is the first of its kind that actually protects the neurons from external stimulus, he said.
The finding will appear on the March edition of the London-based science magazine Nature Genetics.
THE KOREA HERALD 2005.1.31 (thkim@heraldm.com) By Kim Tong-hyung
2005.02.02 View 14025
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Gene Protecting Brain Nerves Discovered
THE KOREA TIMES 2005.1.31By Kim Tae-gyu / Staff Reporter
South Korean scientists have for the first time discovered genes tasked with protecting brain nerves.
Korea Advanced Institute of Science and Technology professor Kim Jae-seob said Sunday the new genes, named pyrexia, shield brain nerves from outside stimuli, including high temperatures.
``The channel gene of pyrexia will open the door to developing new-concept medicines for brain damage in patients of high fever or drug addicts,’’ he said.
The channel gene refers to transport proteins, which provide a static passageway for a variety of essential substances to enter into cells.
``Up until now, a lot of channel genes activated by temperatures have been identified. But among them, pyrexia is first that guards brain nerves from external stresses,’’ Kim said.
Kim’s team learned pyrexia plays a pivotal role in the body through experiments with genetically engineered flies that did not have any pyrexia.
Up to 60 percent of the pyrexia-depleted mutants were paralyzed within three minutes of exposure to a temperature of 40 degrees Celsius.
In comparison, just 9 percent of normal flies were paralyzed with the same stimulus, indicating pyrexia is responsible for protecting animals from high-temperature stress.
``Our next goal is to develop pyrexia-embedded drugs, which can be expected to commercially debut in about five years,’’ Kim said.
Kim has already applied for international patents for his medical breakthrough, which will be printed in the March edition of Nature Genetics, a science journal.
voc200@koreatimes.co.kr
2005.02.02 View 14159