sensor
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Blood-Based Multiplexed Diagnostic Sensor Helps to Accurately Detect Alzheimer’s Disease
A research team at KAIST reported clinically accurate multiplexed electrical biosensor for detecting Alzheimer’s disease by measuring its core biomarkers using densely aligned carbon nanotubes.
Alzheimer’s disease is the most prevalent neurodegenerative disorder, affecting one in ten aged over 65 years. Early diagnosis can reduce the risk of suffering the disease by one-third, according to recent reports. However, its early diagnosis remains challenging due to the low accuracy but high cost of diagnosis.
Research team led by Professors Chan Beum Park and Steve Park described an ultrasensitive detection of multiple Alzheimer's disease core biomarker in human plasma. The team have designed the sensor array by employing a densely aligned single-walled carbon nanotube thin films as a transducer.
The representative biomarkers of Alzheimer's disease are beta-amyloid42, beta-amyloid40, total tau protein, phosphorylated tau protein and the concentrations of these biomarkers in human plasma are directly correlated with the pathology of Alzheimer’s disease.
The research team developed a highly sensitive resistive biosensor based on densely aligned carbon nanotubes fabricated by Langmuir-Blodgett method with a low manufacturing cost.
Aligned carbon nanotubes with high density minimizes the tube-to-tube junction resistance compared with randomly distributed carbon nanotubes, which leads to the improvement of sensor sensitivity. To be more specific, this resistive sensor with densely aligned carbon nanotubes exhibits a sensitivity over 100 times higher than that of conventional carbon nanotube-based biosensors.
By measuring the concentrations of four Alzheimer’s disease biomarkers simultaneously Alzheimer patients can be discriminated from health controls with an average sensitivity of 90.0%, a selectivity of 90.0% and an average accuracy of 88.6%.
This work, titled “Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma”, were published in Nature Communications on January 8th 2020. The authors include PhD candidate Kayoung Kim and MS candidate Min-Ji Kim.
Professor Steve Park said, “This study was conducted on patients who are already confirmed with Alzheimer’s Disease. For further use in practical setting, it is necessary to test the patients with mild cognitive impairment.” He also emphasized that, “It is essential to establish a nationwide infrastructure, such as mild cognitive impairment cohort study and a dementia cohort study. This would enable the establishment of world-wide research network, and will help various private and public institutions.”
This research was supported by the Ministry of Science and ICT, Human Resource Bank of Chungnam National University Hospital and Chungbuk National University Hospital.
< A schematic diagram of a high-density aligned carbon nanotube-based resistive sensor that distinguishes patients with Alzheimer’s Disease by measuring the concentration of four biomarkers in the blood. >
Profile:
Professor Steve Park
stevepark@kaist.ac.kr
Department of Materials Science and Engineering
http://steveparklab.kaist.ac.kr/
KAIST
Profile:
Professor Chan Beum Park
parkcb at kaist.ac.kr
Department of Materials Science and Engineering
http://biomaterials.kaist.ac.kr/
KAIST
2020.02.07 View 8941 -
New Liquid Metal Wearable Pressure Sensor Created for Health Monitoring Applications
Soft pressure sensors have received significant research attention in a variety of fields, including soft robotics, electronic skin, and wearable electronics. Wearable soft pressure sensors have great potential for the real-time health monitoring and for the early diagnosis of diseases.
A KAIST research team led by Professor Inkyu Park from the Department of Mechanical Engineering developed a highly sensitive wearable pressure sensor for health monitoring applications. This work was reported in Advanced Healthcare Materials on November 21 as a front cover article.
This technology is capable of sensitive, precise, and continuous measurement of physiological and physical signals and shows great potential for health monitoring applications and the early diagnosis of diseases.
A soft pressure sensor is required to have high compliance, high sensitivity, low cost, long-term performance stability, and environmental stability in order to be employed for continuous health monitoring. Conventional solid-state soft pressure sensors using functional materials including carbon nanotubes and graphene have showed great sensing performance. However, these sensors suffer from limited stretchability, signal drifting, and long-term instability due to the distance between the stretchable substrate and the functional materials.
To overcome these issues, liquid-state electronics using liquid metal have been introduced for various wearable applications. Of these materials, Galinstan, a eutectic metal alloy of gallium, indium, and tin, has great mechanical and electrical properties that can be employed in wearable applications. But today’s liquid metal-based pressure sensors have low-pressure sensitivity, limiting their applicability for health monitoring devices.
The research team developed a 3D-printed rigid microbump array-integrated, liquid metal-based soft pressure sensor. With the help of 3D printing, the integration of a rigid microbump array and the master mold for a liquid metal microchannel could be achieved simultaneously, reducing the complexity of the manufacturing process. Through the integration of the rigid microbump and the microchannel, the new pressure sensor has an extremely low detection limit and enhanced pressure sensitivity compared to previously reported liquid metal-based pressure sensors. The proposed sensor also has a negligible signal drift over 10,000 cycles of pressure, bending, and stretching and exhibited excellent stability when subjected to various environmental conditions.
These performance outcomes make it an excellent sensor for various health monitoring devices. First, the research team demonstrated a wearable wristband device that can continuously monitor one’s pulse during exercise and be employed in a noninvasive cuffless BP monitoring system based on PTT calculations. Then, they introduced a wireless wearable heel pressure monitoring system that integrates three 3D-BLiPS with a wireless communication module.
Professor Park said, “It was possible to measure health indicators including pulse and blood pressure continuously as well as pressure of body parts using our proposed soft pressure sensor. We expect it to be used in health care applications, such as the prevention and the monitoring of the pressure-driven diseases such as pressure ulcers in the near future. There will be more opportunities for future research including a whole-body pressure monitoring system related to other physical parameters.”
This work was supported by a National Research Foundation of Korea (NRF) grant funded by the Ministry of Science and ICT.
< Figure 1. The front cover image of Advanced Healthcare Materials, Volume 8, Issue 22. >
< Figure 2. Highly sensitive liquid metal-based soft pressure sensor integrated with 3D-printed microbump array. >
< Figure 3. High pressure sensitivity and reliable sensing performances of the proposed sensor and wireless heel pressure monitoring application. >
-ProfileProfessor Inkyu ParkMicro/Nano Transducers Laboratoryhttp://mintlab1.kaist.ac.kr/
Department of Mechanical EngineeringKAIST
2019.12.20 View 11889 -
Professor Il-Doo Kim Named Scientist of the Year by the Journalists
Professor Il-Doo Kim from the Department of Materials Science and Engineering was named the 2019 Scientist of the Year by Korean science journalists. The award was conferred at the 2019 Science Press Night ceremony of the Korea Science Journalists Association (KSJA) on November 29.
Professor Kim focuses on developing nanofiber gas sensors for diagnosing diseases in advance by analyzing exhaled biomarkers with electrospinning technology. His outstanding research was praised and selected as one of the top 10 nanotechnology of 2019 by the Korea Nano Technology Research Society (KoNTRS), the Ministry of Science and ICT (MSIT), and the Ministry of Trade, Industry and Energy (MOTIE).
Professor Kim was honored with the QIAN Baojun Fiber Award, which is awarded every two years by Donghua University in Shanghai, China to recognize outstanding contributions in fiber science and technology. Professor Kim was also elected as an academician of the Asia Pacific Academy of Materials (APAM) on November 21 in Guangzhou, China.
In May, Professor Kim was appointed as an associate editor of ACS Nano, a leading international research journal in the field of nanoscience. In his editorial published in the May issue of ACS Nano, Professor Kim introduced and shared the history of KAIST and its vision for the future with other members of the journal. He hopes this will help with promoting a closer relationship between the members of the journal and KAIST moving forward.
“Above all,” he said in his acceptance speech, “the greatest news for me as an educator is that the first PhD graduate from our lab, Dr. Seonjin Choi, was appointed as the youngest professor in the Division of Materials Science and Engineering at Hanyang University on September 1.”
2019.12.17 View 9133 -
Professor Hyun Gyu Park Appointed as Associate Editor for Biosensors and Bioelectronics
Professor Hyun Gyu Park from the Department of Chemical and Biomolecular Engineering was appointed as an associate editor for Biosensors and Bioelectronics, an international journal published by Elsevier.
Biosensors and Bioelectronics is one of the top SCI journals in the fields of chemistry and analytical science (IF 9.518 as of 2018). Professor Park was recognized and appointed as the associate editor for this journal due to his outstanding research achievements in the fields of nucleic acid engineering, biosensors, and nanobiotechnology.
Professor Park will serve as the associate editor from this October until December 2021.
(END)
2019.10.01 View 5758 -
Highly Uniform and Low Hysteresis Pressure Sensor to Increase Practical Applicability
< Professor Steve Park (left) and the First Author Mr. Jinwon Oh (right) >
Researchers have designed a flexible pressure sensor that is expected to have a much wider applicability. A KAIST research team fabricated a piezoresistive pressure sensor of high uniformity with low hysteresis by chemically grafting a conductive polymer onto a porous elastomer template.
The team discovered that the uniformity of pore size and shape is directly related to the uniformity of the sensor. The team noted that by increasing pore size and shape variability, the variability of the sensor characteristics also increases.
Researchers led by Professor Steve Park from the Department of Materials Science and Engineering confirmed that compared to other sensors composed of randomly sized and shaped pores, which had a coefficient of variation in relative resistance change of 69.65%, their newly developed sensor exhibited much higher uniformity with a coefficient of variation of 2.43%. This study was reported in Small as the cover article on August 16.
Flexible pressure sensors have been actively researched and widely applied in electronic equipment such as touch screens, robots, wearable healthcare devices, electronic skin, and human-machine interfaces. In particular, piezoresistive pressure sensors based on elastomer‐conductive material composites hold significant potential due to their many advantages including a simple and low-cost fabrication process.
Various research results have been reported for ways to improve the performance of piezoresistive pressure sensors, most of which have been focused on increasing the sensitivity. Despite its significance, maximizing the sensitivity of composite-based piezoresistive pressure sensors is not necessary for many applications. On the other hand, sensor-to-sensor uniformity and hysteresis are two properties that are of critical importance to realize any application.
The importance of sensor-to-sensor uniformity is obvious. If the sensors manufactured under the same conditions have different properties, measurement reliability is compromised, and therefore the sensor cannot be used in a practical setting.
In addition, low hysteresis is also essential for improved measurement reliability. Hysteresis is a phenomenon in which the electrical readings differ depending on how fast or slow the sensor is being pressed, whether pressure is being released or applied, and how long and to what degree the sensor has been pressed. When a sensor has high hysteresis, the electrical readings will differ even under the same pressure, making the measurements unreliable.
Researchers said they observed a negligible hysteresis degree which was only 2%. This was attributed to the strong chemical bonding between the conductive polymer and the elastomer template, which prevents their relative sliding and displacement, and the porosity of the elastomer that enhances elastic behavior.
“This technology brings forth insight into how to address the two critical issues in pressure sensors: uniformity and hysteresis. We expect our technology to play an important role in increasing practical applications and the commercialization of pressure sensors in the near future,” said Professor Park.
This work was conducted as part of the KAIST‐funded Global Singularity Research Program for 2019, and also supported by the KUSTAR‐KAIST Institute.
Figure 1. Image of a porous elastomer template with uniform pore size and shape (left), Graph showing high uniformity in the sensors’ performance (right).
Figure 2. Hysteresis loops of the sensor at different pressure levels (left), and after a different number of cycles (right).
Figure 3. The cover page of Small Journal, Volume 15, Issue 33.
Publication:
Jinwon Oh, Jin‐Oh Kim, Yunjoo Kim, Han Byul Choi, Jun Chang Yang, Serin Lee, Mikhail Pyatykh, Jung Kim, Joo Yong Sim, and Steve Park. 2019. Highly Uniform and Low Hysteresis Piezoresistive Pressure Sensors Based on Chemical Grafting of Polypyrrole on Elastomer Template with Uniform Pore Size. Small. Wiley-VCH Verlag GmbH & Co. KgaA, Weinheim, Germany, Volume No. 15, Issue No. 33, Full Paper No. 201901744, 8 pages. https://doi.org/10.1002/smll.201901744
Profile: Prof. Steve Park, MS, PhD
stevepark@kaist.ac.kr
http://steveparklab.kaist.ac.kr/
Assistant Professor
Organic and Nano Electronics Laboratory
Department of Materials Science and Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon 34141, Korea
Profile: Mr. Jinwon Oh, MS
jwoh1701@gmail.com
http://steveparklab.kaist.ac.kr/
Researcher
Organic and Nano Electronics Laboratory
Department of Materials Science and Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr Daejeon 34141, Korea
Profile: Prof. Jung Kim, MS, PhD
jungkim@kaist.ac.kr
http://medev.kaist.ac.kr/
Professor
Biorobotics Laboratory
Department of Mechanical Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr Daejeon 34141, Korea
Profile: Joo Yong Sim, PhD
jsim@etri.re.kr
Researcher
Bio-Medical IT Convergence Research Department
Electronics and Telecommunications Research Institute (ETRI)
https://www.etri.re.krDaejeon 34129, Korea
(END)
2019.08.19 View 25621 -
2017 KAIST Research Day Honors Professor Hoon Sohn
The 2017 KAIST Research Day recognized Professor Hoon Sohn of the Department of Civil and Environmental Engineering as Research Grand Prize Awardee in addition to the 10 most distinguished research achievements of the past year.
The Research Grand Prize recognizes the professor whose comprehensive research performance evaluation indicator is the highest over the past five years. The indicator combines the factors of the number of research contracts, IPR, royalty income, as well as research overhead cost inclusion.
During the ceremony, which was held on May 23, Professor Jun-Ho Oh of the Department of Mechanical Engineering and Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering also won the Best Research Award. The two professors had the best scores when evaluating their research performance for one-year periods.
Meanwhile, the Research Innovation Award went to Professor YongKeun Park of the Department of Physics. The Research Innovation Award scores the factors of foreign patent registration, contracts of technological transfer and income from technology fees, technology consultations, and startups and selected Professor Park as the top winner.
Professors Yong Hee Lee of the Department of Physics and Jonghwa Shin of the Department of Material Science won the Convergence Research Award. The Convergence Research Award recognizes the most outstanding research team who created innovative research results for a year.
After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.” the Research Day ceremony, KAIST also presented the ten most distinguished research achievements made by KAIST professors during the last year as follows (Click):
▲ Commercialization of 3D Holographic Microscopy by Professor YongKeun Park of the Department of Physics
▲ Designer Proteins with Chemical Modifications by Professor Hee-Sung Park of the Department of Chemistry
▲ Lanthanum-Catalyzed Synthesis of Microporous 3D Graphene-Like Carbons in a Zeolite Template by Professor Ryong Ryoo of the Department of Chemistry
▲ Complete Prevention of Blood Loss by Self-Sealing Hemostatic Needles by Professor Haeshin Lee of the Department of Chemistry
▲ An Immunological Mechanism for the Contribution of Commensal Microbiota Against Herpes Simplex Virus Infection in Genital Mucosa by Heung Kyu Lee of the Graduate School of Medical Science and Engineering
▲ Development of a Pulse-Echo Laser Ultrasonic Propagation Imaging System by Professor Jung-Ryul Lee of the Department of Aerospace Engineering
▲ Bi-refractive Stereo Imaging for Single-Shot Depth Acquisition by Professor Min H. Kim of the School of Computing
▲ Development of Environment Friendly Geotechnical Construction Material Using Biopolymer by Professor Gye-Chun Cho of the Department of Civil and Environmental Engineering
▲ Protein Delivery Via Engineered Exosomes by Professor Chulhee Choi of the Department of Bio and Brain Engineering
▲ Hot Electron Detection Under Catalytic Reactions by Professor Jeong Young Park of the Graduate School of EEWS.
After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.”
(Photo:President Shin poses with the 2017 KAIST Research Grand Prize Winner Professor Hoon Sohn on May 23.)
2017.05.23 View 11316 -
Professor Junehwa Song Appointed as the General Chair of the Organizing Committee of ACM SenSys
Professor Junehwa Song from the Schooling of Computing at KAIST has been appointed the general chair of the organizing committee of ACM SenSys—the American Computing Machine (ACM) Conference on Embedded Networked Sensor Systems.
ACM SenSys held its first conference in 2003 to promote research on wireless sensor networks and embedded systems. Since then, it has expanded into an influential international conference especially with the increasing importance in sensor technologies. Recently the committee has expanded its field of interest to mobile sensors, the Internet of Things, smart device system, and security.
Professor Song is considered a world-renown researcher in mobile and ubiquitous computing system. He presented numerous research papers at various conferences organized by ACM. He is also a member of the editorial committee of the Institute of Electrical and Electronics Engineers (IEEE) Transactions on Mobile Computing journal. For his achievements in the field and flair for coordinating and planning conferences, he is now the first Korean researcher to be appointed the chair of ACM SenSys.
Professor Song said that, as the chair, he would help discover new technology in and applications of networked, wireless sensors that would meet the demands of our modern society.
The 13th ACM SenSys will take place in Seoul—the first one to be held in Asia. The event will begin on November 1, 2015 and last four days. More information about this year’s event can be found at http://sensys.acm.org/2015/.
2015.10.02 View 6449 -
Dr. Hyundoo Hwang Receives a Tenured Position at Monterrey Institute of Technology and Higher Education
Hyundoo Hwang, a former graduate student in the Department of Bio & Brain Engineering at KAIST, has been granted a tenured position at the Monterrey Institute of Technology and Higher Education (ITSEM), Mexico.
Dr. Hwang received his bachelor’s, master’s, and doctoral degree at KAIST and started his professorship at Ulsan National Institute of Science & Technology (UNIST) in Korea. He continued his research in the United States as a professor at Georgia Institute of Technology. He has been acknowledged for the development of an advanced nanotechnology for the diagnosis of rare diseases and research in cell signals. He is one of the leading researchers in an international research project in microelectromechanical systems (MEMS) with participation by researchers from over ten countries. He has been active in commercializing biosensor technology in the U.S. and Mexico.
Since its establishment in 1943, ITSEM has grown to 33 campuses in 25 cities in Mexico. It is the largest university in Latin America with over 90,000 students (47% of its graduate students has oversea research experience). It recruits over 5,000 international students and professors every year.
Dr. Hwang will begin teaching at ITSEM as a professor in the Department of Biomedical Engineering (Ingeniería Biomédica) this fall. He will also conduct research in nano- and micro-technology as a member of Sensors and Devices research group.
Professor Gwang Hyun Cho, head of KAIST's Department of Bio and Brain Engineering said that Dr. Hwang’s tenure professorship at ITSEM demonstrated that the academic program at KAIST—from undergraduate to doctoral—was on par with the international standard. He hoped that more talents from the department would seek academic careers in internationally renowned universities around the world.
2015.08.13 View 5755 -
KAIST's Center for Integrated Smart Sensors made a partnership with a Silicon Valley start-up
KAIST's Center for Integrated Smart Sensors (CISS) will implement a joint venture project with Dual Aperture, Inc., a leading digital camera provider based in Palo Alto, California. The two will work on the development of 3-D imaging technology.
CISS, headed by Professor Chong-Min Kyung of Electrical Engineering, KAIST, is dedicated to technological advancement by developing innovative devices, circuits, and smart sensors.
In its press release dated June 18, 2014, Dual Aperture, Inc. stated that “by combining top talents in engineering, the partnership will establish a groundbreaking smart sensor technology accessible on multiple platforms and devices.”
For details, a Fox news article follows below:
Dual Aperture, Inc., June 18, 2014
“Image technology leader and top research institute collaborate engineering resources to create world’s first-ever smart sensor technology”
http://www.fox14tv.com/story/25808022/dual-aperture-announces-joint-venture-with-kaists-center-for-integrated-smart-sensors
2014.06.19 View 8561 -
Nanofiber sensor detects diabetes or lung cancer faster and easier
Metal-oxide nanofiber based chemiresistive gas sensors offer greater usability for portable real-time breath tests that can be available on smart phones or tablet PCs in the near future.
Daejeon, Republic of Korea, June 11, 2013 -- Today"s technological innovation enables smartphone users to diagnose serious diseases such as diabetes or lung cancer quickly and effectively by simply breathing into a small gadget, a nanofiber breathing sensor, mounted on the phones.
Il-Doo Kim, Associate Professor of Materials Science and Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST), and his research team have recently published a cover paper entitled "Thin-Wall Assembled SnO2 Fibers Functionalized by Catalytic Pt Nanoparticles and their Superior Exhaled Breath-Sensing Properties for the Diagnosis of Diabetes," in an academic journal, Advanced Functional Materials (May 20th issue), on the development of a highly sensitive exhaled breath sensor by using hierarchical SnO2 fibers that are assembled from wrinkled thin SnO2 nanotubes.
In the paper, the research team presented a morphological evolution of SnO2 fibers, called micro phase-separations, which takes place between polymers and other dissolved solutes when varying the flow rate of an electrospinning solution feed and applying a subsequent heat treatment afterward.
The morphological change results in nanofibers that are shaped like an open cylinder inside which thin-film SnO2 nanotubes are layered and then rolled up. A number of elongated pores ranging from 10 nanometers (nm) to 500 nm in length along the fiber direction were formed on the surface of the SnO2 fibers, allowing exhaled gas molecules to easily permeate the fibers. The inner and outer wall of SnO2 tubes is evenly coated with catalytic platinum (Pt) nanoparticles. According to the research team, highly porous SnO2 fibers, synthesized by eletrospinning at a high flow rate, showed five-fold higher acetone responses than that of the dense SnO2 nanofibers created under a low flow rate. The catalytic Pt coating shortened the fibers" gas response time dramatically as well.
The breath analysis for diabetes is largely based on an acetone breath test because acetone is one of the specific volatile organic compounds (VOC) produced in the human body to signal the onset of particular diseases. In other words, they are biomarkers to predict certain diseases such as acetone for diabetes, toluene for lung cancer, and ammonia for kidney malfunction. Breath analysis for medical evaluation has attracted much attention because it is less intrusive than conventional medical examination, as well as fast and convenient, and environmentally friendly, leaving almost no biohazard wastes.
Various gas-sensing techniques have been adopted to analyze VOCs including gas chromatography-mass spectroscopy (GC-MS), but these techniques are difficult to incorporate into portable real-time gas sensors because the testing equipment is bulky and expensive, and their operation is more complex. Metal-oxide based chemiresistive gas sensors, however, offer greater usability for portable real-time breath sensors.
Il-Doo Kim said, "Catalyst-loaded metal oxide nanofibers synthesized by electrospinning have a great potential for future exhaled breath sensor applications. From our research, we obtained the results that Pt-coated SnO2 fibers are able to identify promptly and accurately acetone or toluene even at very low concentration less than 100 parts per billion (ppb)."
The exhaled acetone level of diabetes patients exceeds 1.8 parts per million (ppm), which is two to six-fold higher than that (0.3-0.9 ppm) of healthy people. Therefore, a highly sensitive detection that responds to acetone below 1 ppm, in the presence of other exhaled gases as well as under the humid environment of human breath, is important for an accurate diagnosis of diabetes. In addition, Professor Kim said, "a trace concentration of toluene (30 ppb) in exhaled breath is regarded to be a distinctive early symptom of lung cancer, which we were able to detect with our prototype breath tester."
The research team has now been developing an array of breathing sensors using various catalysts and a number of semiconducting metal oxide fibers, which will offer patients a real-time easy diagnosis of diseases.
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Youtube Link: http://www.youtube.com/watch?v=t_Hr11dRryg
For further inquires:
Il-Doo Kim, Professor of Materials Science and Engineering, KAIST
Advanced Nanomaterials and Energy Laboratory
Tel: +82-42-350-3329
Email: idkim@kaist.ac.kr
Clockwise from left to right: left upper shows a magnified SEM image of a broken thin-wall assembled SnO2 fiber. Left below is an array of breath sensors (Inset is an actual size of a breath sensor). The right is the cover of Advanced Functional Materials (May 20th issue) in which a research paper on the development of a highly sensitive exhaled breath sensor by using SnO2 fibers is published.
This is the microstructural evolution of SnO2 nanofibers as a function of flow rate during electrospinning.
2013.06.20 View 13377 -
Professor Choi Chul Hui appointed as editor-in-chief of Nanobiosensors in a disease diagnosis magazine
Professor Choi Chul Hui of the Department of Biological and Brain Engineering has been appointed the editor-in-chief of Nanobiosensors, an international medical magazine that concentrates on disease diagnosis.
As the editor-in-chief, Professor Choi will be involved in dissertation evaluations and overall direction of the magazine.
Professor Choi is one of the leading authorities in the field of clinical medicine and has published 60 SCI level dissertations in the fields of cell biology, computational biology, and bio-optics.
He is also the executive director of the KAIST BioImaging Research Center, and his research lab focuses on cell signals and bio imaging. Professor Choi is researching the generation process of degenerative diseases like arteriosclerosis by taking a multidisciplinary approach.
Professor Choi has recently developed a new bio imaging technique that allows for the measurement of perfusion and a new technology for the drug delivery to nerves using ultra short wavelength laser beams.
2011.10.10 View 9775 -
New Technology Developed for Analysis of New Drugs by Using Smart Nano-Sensors
Doctor Sang-Kyu Lee
Doctor Sang-Kyu Lee of the Department of Biological Sciences, KAIST, has developed the technology that allows biological nano particles to be implanted into human cells for monitoring the effect of new drugs in real time from within the cell. It is expected that this technology will boost the ability to weigh the effects and properties of a new drug more quickly and accurately.
Conventionally, the candidate drug was injected into the human body, and then its cells are extracted to analyze the effects of the drugs. The problem with this method was that the cells were analyzed at a ‘dead’ state which made it incredibly difficult to find candidate substances due to uncontrollable side effects. This made the development of new drugs very difficult despite the large costs and efforts invested into its development.
The research team latched onto the idea that nanoparticles can connect to form a large complex. The complex acts as a nanosensor which allows for real time observation of drug target and the drug itself binding.
The team named the nanosensor technology ‘InCell SMART-i’ and was named ‘Hot Paper’ of the September edition of ‘Angewandte Chemie International Edition’ magazine, a world famous Chemistry Magazine.When a new drug injected into the human body, the drug and drug targets are gradually combined, and the smart nanosensor detects in real time the effect of the new drug as shown in the pictures above (shaded spot).
2011.09.19 View 9005