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Biomarker Predicts Who Will Have Severe COVID-19
- Airway cell analyses showing an activated immune axis could pinpoint the COVID-19 patients who will most benefit from targeted therapies.-
KAIST researchers have identified key markers that could help pinpoint patients who are bound to get a severe reaction to COVID-19 infection. This would help doctors provide the right treatments at the right time, potentially saving lives. The findings were published in the journal Frontiers in Immunology on August 28.
People’s immune systems react differently to infection with SARS-CoV-2, the virus that causes COVID-19, ranging from mild to severe, life-threatening responses.
To understand the differences in responses, Professor Heung Kyu Lee and PhD candidate Jang Hyun Park from the Graduate School of Medical Science and Engineering at KAIST analysed ribonucleic acid (RNA) sequencing data extracted from individual airway cells of healthy controls and of mildly and severely ill patients with COVID-19. The data was available in a public database previously published by a group of Chinese researchers.
“Our analyses identified an association between immune cells called neutrophils and special cell receptors that bind to the steroid hormone glucocorticoid,” Professor Lee explained. “This finding could be used as a biomarker for predicting disease severity in patients and thus selecting a targeted therapy that can help treat them at an appropriate time,” he added.
Severe illness in COVID-19 is associated with an exaggerated immune response that leads to excessive airway-damaging inflammation. This condition, known as acute respiratory distress syndrome (ARDS), accounts for 70% of deaths in fatal COVID-19 infections.
Scientists already know that this excessive inflammation involves heightened neutrophil recruitment to the airways, but the detailed mechanisms of this reaction are still unclear.
Lee and Park’s analyses found that a group of immune cells called myeloid cells produced excess amounts of neutrophil-recruiting chemicals in severely ill patients, including a cytokine called tumour necrosis factor (TNF) and a chemokine called CXCL8.
Further RNA analyses of neutrophils in severely ill patients showed they were less able to recruit very important T cells needed for attacking the virus. At the same time, the neutrophils produced too many extracellular molecules that normally trap pathogens, but damage airway cells when produced in excess.
The researchers additionally found that the airway cells in severely ill patients were not expressing enough glucocorticoid receptors. This was correlated with increased CXCL8 expression and neutrophil recruitment.
Glucocorticoids, like the well-known drug dexamethasone, are anti-inflammatory agents that could play a role in treating COVID-19. However, using them in early or mild forms of the infection could suppress the necessary immune reactions to combat the virus. But if airway damage has already happened in more severe cases, glucocorticoid treatment would be ineffective.
Knowing who to give this treatment to and when is really important. COVID-19 patients showing reduced glucocorticoid receptor expression, increased CXCL8 expression, and excess neutrophil recruitment to the airways could benefit from treatment with glucocorticoids to prevent airway damage. Further research is needed, however, to confirm the relationship between glucocorticoids and neutrophil inflammation at the protein level.
“Our study could serve as a springboard towards more accurate and reliable COVID-19 treatments,” Professor Lee said.
This work was supported by the National Research Foundation of Korea, and Mobile Clinic Module Project funded by KAIST.
Figure. Low glucocorticoid receptor (GR) expression led to excessive inflammation and lung damage by neutrophils through enhancing the expression of CXCL8 and other cytokines.
Image credit: Professor Heung Kyu Lee, KAIST. Created with Biorender.com.
Image usage restrictions: News organizations may use or redistribute these figures and image, with proper attribution, as part of news coverage of this paper only.
-Publication:
Jang Hyun Park, and Heung Kyu Lee. (2020). Re-analysis of Single Cell Transcriptome Reveals That the NR3C1-CXCL8-Neutrophil Axis Determines the Severity of COVID-19. Frontiers in Immunology, Available online at https://doi.org/10.3389/fimmu.2020.02145
-Profile: Heung Kyu Lee
Associate Professor
heungkyu.lee@kaist.ac.kr
https://www.heungkyulee.kaist.ac.kr/
Laboratory of Host Defenses
Graduate School of Medical Science and Engineering (GSMSE)
The Center for Epidemic Preparedness at KAIST Institute
http://kaist.ac.kr
Korea Advanced Institute of Science and Technology (KAIST)
Daejeon, Republic of Korea
Profile: Jang Hyun Park
PhD Candidate
janghyun.park@kaist.ac.kr
GSMSE, KAIST
2020.09.17 View 13376 -
Education, a Silver Lining in the Dark COVID-19 Cloud
If there is a silver lining behind the COVID-19 pandemic clouds engulfing the world in darkness, it would be ‘education’. The disruption caused by the pandemic has reminded us of the skills that students need in this unpredictable world and raised public awareness of guaranteeing continuous, fair, and quality learning opportunities. Educational innovation can become a positive and powerful catalyst to transform the world for a better future in the post-COVID era.
According to the speakers at the virtual forum co-hosted by the Global Strategy Institute (GSI) and Korea Policy Center for the Fourth Industrial Revolution (KPC4IR) at KAIST on June 24, the recent transition to remote education amplifies the existing socio-economic disparities between the haves and the have-nots, and narrowing the digital divide is the most urgent challenge that should be addressed in this ever-evolving technology-dominating era. They also called for students to be resilient despite the numerous uncertainties ahead of them and prepare new skill sets to better adjust to new environments.
KAIST launched the GSI as its think tank in February of this year. The GSI aims to identify global issues proactively and help make breakthroughs well aligned with solid science and technology-based policies. The second forum of the KAIST GSI, following its inaugural forum in April, was held under the theme “Envisioning the Future of Education for a Non-Contact Society in the Post-Coronavirus Era”.
In his opening remarks, KAIST President Sung-Chul Shin stressed that “distance teaching and learning will eventually become integral components of our future education system”. He then called for close collaboration between the public and private sectors to better shape the future of digital education. President Shin said that global cooperation is also needed to continue offering inclusive, quality education that can equally benefit every student around the world. “We should never let a crisis go to waste, and the COVID-19 pandemic is no exception,” he added.
CEO of Minerva Schools Ben Nelson described the current coronavirus crisis as “an earthquake happening deep down on the ocean floor – we don’t feel it, but it can cause a devastating tsunami.” He continued, “Online learning can totally change the current education system forever.”
Saying that blended education, which combines online and offline classes, will be the new norm in the post-coronavirus era, Coursera CEO Jeff Maggioncalda anticipates that institutions will have to offer more and more online courses and credentials, and should at the same time prepare to drive down the cost of education as students expect to pay much less in tuition and fees for online learning options. “With the economy slumping and unemployment soaring, job-relevant education will also be a must,” Maggioncalda said.
National University of Singapore President Tan Eng Chye further pointed out that future education systems should prepare students to be creative lifelong learners. President Tan encouraged students to be able to integrate knowledge and technical skills from multiple disciplines for complex problem solving, and be adaptable and resilient with bigger appetites for risks and a higher tolerance for failures. He also mentioned digital competency, empathy, and social responsibility as virtues that students in the post-coronavirus era should possess.
Rebecca Winthrop, Co-Director of the Center for Universal Education at the Brookings Institution, raised concerns over the ever-growing digital disparities caused by the recent shift to online teaching and learning, claiming that insufficient infrastructures for low-income families in developing nations are already causing added educational disparities and provoking the inequity issue around the world. “New approaches to leapfrog inequality and provide quality education equally through faster and more effective means should be studied,” she said.
In response to this, Vice President of Microsoft Anthony Salcito introduced the Microsoft Education Transformation Framework, which provides practical advice to develop strategies for digital education transformation with a holistic, long-term view implemented in discrete phases that the global community can begin today. The Framework reportedly shows how emerging technologies, such as artificial intelligence, support new approaches to building efficient and effective physical and digital infrastructure, modernizing teaching and learning, empowering research, and managing student success.
The GSI will host two more forums in September and November.
(END)
2020.06.24 View 11917 -
KAIST Forum Envisions Education in the Post-Covid Era
Global leaders including the CEOs of Minerva and Coursera to join the KAIST online forum to discuss how to facilitate inclusive educational environment amidst the ever-growing digital disparities
An international forum hosted by the KAIST Global Strategy Institute will examine how the disruptions caused by the global pandemic will impact the future of education. Global leaders will reflect on ways to better facilitate inclusive educational environments and mitigate the digital divide, especially in an era where non-contact environments are so critical.
The online forum to be held on June 24 from 09:00 am KST will livestream on YouTube and KTV. This is the second forum hosted by the GSI following its inaugural forum in April.
Minerva School’s CEO Ben Nelson and Coursera CEO Jeff Maggioncalda will be among the 15 speakers who will share their insights on the new transformations in the education sector.
The digital transformation of higher education will be the key topic every speaker will highlight to predict the future education in the post-Covid era. According to UNESCO and UNICEF, 1.6 billion students from 192 countries, which account for 91 percent of the student population in the world, have experienced educational disruptions in the past four months. Approximately 29 percent of the youth worldwide, around 346 million individuals, are not online.
KAIST President Sung-Chul Shin’s opening remarks will stress that technological breakthroughs should be used to benefit us all and the private and public sectors should collaborate to facilitate an inclusive educational environment.
Ben Nelson believes that global universities are at the point of inflection for making tough choices to reform higher education. He will introduce what will affect the decision-making procedure for investing in the digital transformation and the best recipe for building a successful remote learning environment.
Dr. Paul Kim, CTO and Assistant Dean of Stanford Graduate School of Education, will analyze the ramifications brought about by Covid-19 among both advanced countries and developing countries, and propose an optimal educational model for developing countries.
Phil Baty, Chief Knowledge Officer at Times Higher Education, will present the key survey results the Times Higher Education made with approximately 200 university presidents on how higher education will adapt in the years to come.
As for innovation in higher education, Vice President at Microsoft Anthony Salcito and Professor Tae Eog Lee from the Department of Industrial and Systems Engineering at KAIST will discuss the education innovation solutions they are currently working on and how their projects will continue to develop.
National University of Singapore President Tan Eng Chye will also opine on how education could be more accessible. He will share what is exacerbating educational inequity and how to ensure an inclusive learning environment.
The second session will cover how to cope with the digital inequity.
Director General at the Ministry of Science and ICT Sang Wook Kang will explain the unavoidable online transition that is required to address the educational disruptions. He will also share his ideas on how this crisis can be leveraged to advance the educational environment.
Meanwhile, Rebecca Winthrop, senior fellow and co-director for universal education at Brooking Institution, and Sooinn Lee, CEO and Creative Lead of Enuma, will present on how to reduce the educational disparity during the un-contact era.
Director Joung-Ho Kim at the GSI, who is the organizer of the forum, said that KAIST has been the forerunner in the educational innovation. He hopes that this online forum will provide meaningful momentum to reshape the future of education by addressing the challenges and disruptions this pandemic has caused.
URL Link to Live-Streaming Service: https://www.youtube.com/c/KAISTofficial
2020.06.22 View 9978 -
A Global Campaign of ‘Facts before Rumors’ on COVID-19 Launched
- A KAIST data scientist group responds to facts and rumors on COVID-19 for global awareness of the pandemic. -
Like the novel coronavirus, rumors have no borders. The world is fighting to contain the pandemic, but we also have to deal with the appalling spread of an infodemic that is as contagious as the virus. This infodemic, a pandemic of false information, is bringing chaos and extreme fear to the general public.
Professor Meeyoung Cha’s group at the School of Computing started a global campaign called ‘Facts before Rumors,’ to prevent the spread of false information from crossing borders. She explained, “We saw many rumors that had already been fact-checked long before in China and South Korea now begin to circulate in other countries, sometimes leading to detrimental results. We launched an official campaign, Facts before Rumors, to deliver COVID-19-related facts to countries where the number of cases is now increasing.” She released the first set of facts on March 26 via her Twitter account @nekozzang.
Professor Cha, a data scientist who has focused on detecting global fake news, is now part of the COVID-19 AI Task Force at the Global Strategy Institute at KAIST. She is also leading the Data Science Group at the Institute for Basic Science (IBS) as Chief Investigator.
Her research group worked in collaboration with the College of Nursing at Ewha Woman’s University to identify 15 claims about COVID-19 that circulated on social networks (SNS) and among the general public. The team fact-checked these claims based on information from the WHO and CDCs of Korea and the US. The research group is now working on translating the list of claims into Portuguese, Spanish, Persian, Chinese, Amharic, Hindi, and Vietnamese. Delivering facts before rumors, the team says, will help contain the disease and prevent any harm caused by misinformation.
The pandemic, which spread in China and South Korea before arriving in Europe and the US, is now moving into South America, Africa, and Southeast Asia. “We would like to play a part in preventing the further spread of the disease with the provision of only scientifically vetted, truthful facts,” said the team.
For this campaign, Professor Cha’s team investigated more than 200 rumored claims on COVID-19 in China during the early days of the pandemic. These claims spread in different levels: while some were only relevant locally or in larger regions of China, others propagated in Asia and are now spreading to countries that are currently most affected by the disease.
For example, the false claim which publicized that ‘Fireworks can help tame the virus in the air’ only spread in China. Other claims such as ‘Eating garlic helps people overcome the disease’ or ‘Gargling with salt water prevents the contraction of the disease,’ spread around the world even after being proved groundless.
The team noted, however, that the times at which these claims propagate are different from one country to another. “This opens up an opportunity to debunk rumors in some countries, even before they start to emerge,” said Professor Cha.
Kun-Woo Kim, a master’s candidate in the Department of Industrial Design who joined this campaign and designed the Facts before Rumors chart also expressed his hope that this campaign will help reduce the number of victims. He added, “I am very grateful to our scientists who quickly responded to the Fact Check in these challenging times.”
2020.03.27 View 10773 -
A Mathematical Model Reveals Long-Distance Cell Communication Mechanism
How can tens of thousands of people in a large football stadium all clap together with the same beat even though they can only hear the people near them clapping?
A combination of a partial differential equation and a synthetic circuit in microbes answers this question. An interdisciplinary collaborative team of Professor Jae Kyoung Kim at KAIST, Professor Krešimir Josić at the University of Houston, and Professor Matt Bennett at Rice University has identified how a large community can communicate with each other almost simultaneously even with very short distance signaling. The research was reported at Nature Chemical Biology.
Cells often communicate using signaling molecules, which can travel only a short distance. Nevertheless, the cells can also communicate over large distances to spur collective action. The team revealed a cell communication mechanism that quickly forms a network of local interactions to spur collective action, even in large communities.
The research team used an engineered transcriptional circuit of combined positive and negative feedback loops in E. coli, which can periodically release two types of signaling molecules: activator and repressor. As the signaling molecules travel over a short distance, cells can only talk to their nearest neighbors. However, cell communities synchronize oscillatory gene expression in spatially extended systems as long as the transcriptional circuit contains a positive feedback loop for the activator.
Professor Kim said that analyzing and understanding such high-dimensional dynamics was extremely difficult. He explained, “That’s why we used high-dimensional partial differential equation to describe the system based on the interactions among various types of molecules.” Surprisingly, the mathematical model accurately simulates the synthesis of the signaling molecules in the cell and their spatial diffusion throughout the chamber and their effect on neighboring cells.
The team simplified the high-dimensional system into a one-dimensional orbit, noting that the system repeats periodically. This allowed them to discover that cells can make one voice when they lowered their own voice and listened to the others. “It turns out the positive feedback loop reduces the distance between moving points and finally makes them move all together. That’s why you clap louder when you hear applause from nearby neighbors and everyone eventually claps together at almost the same time,” said Professor Kim.
Professor Kim added, “Math is a powerful as it simplifies complex thing so that we can find an essential underlying property. This finding would not have been possible without the simplification of complex systems using mathematics."
The National Institutes of Health, the National Science Foundation, the Robert A. Welch Foundation, the Hamill Foundation, the National Research Foundation of Korea, and the T.J. Park Science Fellowship of POSCO supported the research.
(Figure: Complex molecular interactions among microbial consortia is simplified as interactions among points on a limit cycle (right).)
2019.10.15 View 24143 -
KAIST-THE Innovation & Impact Summit Touts New Roles of Higher Education
Global leaders from 115 institutions across 35 countries reaffirmed that the roles of universities are evolving to become much broader and more diverse, and redefined the impact of higher education last week at KAIST. During the THE Innovation and Impact Summit hosted by KAIST in partnership with the Times Higher Education, global leaders in higher education, industry, and government all agreed that universities should respond better in order to have a lasting and sustainable impact on society.
In an effort to encourage social responsibility and boost the impact of universities, the THE first launched the University Impact Rankings based on the Sustainable Developed Goals declared during the 2015 UN summit. The THE’s University Impact Rankings are the first global attempt to evaluate universities’ impact on society, rather than only focusing on research and teaching performance.
The new metrics include universities’ policies and outcomes based on 11 of the 17 UN SDGs. More than 500 institutions from 75 countries submitted data for the new rankings. The top three scores from ten of the SDGs were combined with SDG 17 to calculate the final score. The University of Auckland placed first in this new ranking while KAIST ranked fourth in the category of SDG 9 on Industry, Innovation, and Infrastructure.
President Shin said, “KAIST has dedicated itself to producing knowledge that could serve as a growth engine for national development over the past half century. Now, taking on the UN’s 17 SDGs as new indicators, we will do our utmost to become a leading university in creating global value and better serving the world.”
(Phil Baty, chief knowledge officer of THE)
Phil Baty, chief knowledge officer at THE said, “I would like to applaud KAIST for being a pioneer, taking a new way of looking at university excellence. KAIST’s performance was strong overall, but especially outstanding in SDG 9. Its data proves that the university is fully engaged in knowledge creation and entrepreneur activities.”
Keynote speakers all shared their views on disruptive knowledge and how to adjust to the new AI technology-driven, socio-economic culture.
(from left: Lino Guzzella, former ETH Zurich President and Sung-Chul Shin, KAIST President)
Lino Guzzella, former ETH Zurich President, argued in his keynote speech that there has been amazing growth in university enrollments, coupled with a substantial mismatch between what universities teach and what society needs. He went on to say that universities should look beyond the classical university model and find a way to train the next generation in a way that ensures society has a role for them.
“The likelihood of each generation having a higher income at the age of 30 than their parents has diminished dramatically,” he said. He provided data that showed that middle-income professions have been declining, and between 2000 and 2010 the number of very high-skilled jobs and very low-skilled jobs doubled, whereas the number of those in the middle increased far more slowly. He expected that this trend will continue, saying that universities should focus on instilling critical thinking, interdisciplinary studies, and ‘productive failure’ to students in the new era.
He also shared the secret recipe for the reduced youth unemployment statistics in Switzerland. He said that the education system in Switzerland was designed so that only 20 percent of an age cohort undertakes a classical university education, while 80 percent do vocational training run by companies. They learn what is really needed by industry and society from the early stages of their careers, so no mismatch exists.
(Young Suk Chi, chairman of Elsevier)
Meanwhile, Young Suk Chi, chairman of Elsevier, claimed in his keynote speech that universities should stop evaluating researchers only on their publication and citation counts. He said that doing so was driving academics to turn out multiple papers based on a single study in a practice called ‘salami publishing.’ Chi said, “It’s a responsibility we bear together, and we certainly, as industry associates, have to work hard to educate the world that publishing isn’t everything, but the impact is. But the impact is not just citations, either.”
Chi said that there is a global ‘tech-lash’ that has arisen due to falling trust in major IT companies. On the other hand, universities are trustworthy. People perceive that universities are not merely seeking profits, and they can take advantage of it for fostering next generation researchers and CEOs, which can stand for ‘Chief Ethics Officers’.
“Universities are collaborative,” said Chi. Universities’ research will flourish with more collaboration at a global scale. Collaborative research shows higher citation and impact rates. Instead of competing against one another, universities and industries should collaborate for advancing research. He argued further saying, “If they can uphold this reputation, universities, not companies, will be the institutions that people trust to influence and educate the next generation. Universities, in contrast to industry, have long-term vision, can facilitate collaborative research, and are trustworthy.”
(President Joseph Aoun, Northeastern University)
In the last day’s keynote speech, President Joseph Aoun of Northeastern University said that higher education risks becoming obsolete if it does not fully embrace lifelong learning. He also talked about preparing learners to succeed in the AI age.
He said that lifelong learners made up 74 percent of learners in the US, and only 34 percent of universities in the country fill their seats, but higher education has not yet incorporated lifelong learning as part of its core mission. He said that lifelong learning is going to require that we listen to the needs of society, of both individuals and organizations.
He also called for institutions to create curricula based on what he termed ‘humanics’ – the integration of technological literacy, data literacy, and human literacy, and said that this should be combined with experiential learning.
(from left: So Young Kim, Guohua Chen, Aqil Jamal, Mooyoung Jung and Max Lu)
(from left: Hubo and Duncan Ross, chief data officer of THE)
2019.04.09 View 4675 -
Professor Baik Awarded Sangsan Young Mathematician Prize
(Professor Hyungryul Baik)
Professor Hyungryul Baik from the Department of Mathematical Sciences was honored as the recipient of the 2018 Sangsan Prize for Young Mathematicians by the Korean Mathematical Society (KMS).
The Sangsan Prize recognizes young mathematicians who finished their degree within the previous five years and have begun an outstanding research career. Professor Baik was recognized for his studies in the fields of low-dimensional topology, geophysical mathematics, and geometric theory. In particular, his Ph.D. dissertation presented a new criterion that completely identifies the hyperbolic surface group, making an inference about the nature of the hyperbolic manifold group.
Recently, Professor Baik co-published a paper entitled Spaces of Invariant Circular Orders of Groups with Professor Eric Samperton at the University of California Santa Barbara in the renowned academic journal Groups, Geometry, and Dynamics in 2018.
Professor Baik earned his BS at KAIST and finished his MS and Ph.D. in mathematics in 2014 at Cornell University. He joined KAIST as a faculty member last year.
2018.10.30 View 5327 -
KAIST to Host the THE Innovation & Impact Summit in 2019
KAIST and Times Higher Education (THE) agreed to co-host the THE Innovation & Impact Summit at KAIST from April 1 to 3, 2019.
Global leaders from higher education, government, and industry will gather at KAIST to discuss how universities can better innovate for creating a greater impact.
(from left: THE Managing Director Trevor Barratt and KAIST President Sung-Chul Shin)
President Sung-Chul Shin and Trevor Barratt, managing director at the THE, signed an agreement to host the 2019 THE Innovation & Impact Summit at KAIST next April. The agreement was signed on February 6 during the THE Asia Universities Summit held at SUSTech in Shenzhen in China. Phil Baty, editorial director at the THE was also present during the agreement.
By hosting the 2019 THE Innovation & Impact Summit, KAIST has a chance to introduce its innovative research and performance and its educational environment and startup ecosystem to the world. Having educational and industrial leaders meet at KAIST will add more power to the global status and capacity of KAIST.
The THE Innovation & Impact Summit, first held in 2017, is one in the seven presidential summit series held by THE. During the second summit at KAIST, THE will launch their world university innovation rankings for the first time.
As innovation at universities and its impact have been a crucial indicator in building an institutional brand and reputation, leading universities are gearing up to encourage startups and entrepreneurship education. Even more, innovation at universities is emerging as one of the growth engines of economies.
The innovation indicators of KAIST have been highly recognized by many global ranking institutions in terms of the volume of patents and the patents-to-article citation impact. Thomson Reuters has recognized KAIST for two consecutive years as the most innovative university in Asia, and sixth in the world.
President Shin has high expectations for the hosting of the Innovation & Impact Summit at KAIST. He explained, “Innovation makes up the DNA of KAIST and it has been our institutional mission from the start in 1971. KAIST was commissioned to make innovation for industrialization and economic development through education and research. I do not see any university more suitable than KAIST to host this innovation summit. I hope the summit at KAIST will serve as a global platform to provide very creative ideas for making innovation and collaboration among the leading universities for all the participants.”
Meanwhile, at the THE Asia Universities Summit in Shenzhen, how to respond to the implications of the Fourth Industrial Revolution was the key agenda piercing the two-day sessions.
As a panelist, President Shin shared his experiences on innovative strategies viable for spearheading university reform for the Fourth Industrial Revolution, along with Vice-Chancellor of the University of Sheffield Sir Keith Burnett, President of Monash University Margaret Gardner, and President of Hong Kong Polytechnic University President Timothy W. Tong. He said that universities should foster young talents by equipping them with creativity, collaboration, and convergent minds. To swiftly respond to the new industrial environment, President Shin said that universities should remove the high barriers between departments and establish cross- and inter-disciplinary education systems, convergence research and technology commercialization.
2018.02.06 View 7640 -
Professor Lee Recognized by the KMS as Best Paper Awardee
Professor Ji Oon Lee of the Department of Mathematical Sciences was selected as the 2017 Best Paper Awardee by the Korean Mathematical Society. The award will be presented during the KMS spring meeting on April 29. Dr. Lee is being honored for proving a necessary and sufficient condition for the Tracy-Wisdom law of Wigner matrices. In a paper titled ‘A Necessary and Sufficient Condition for Edge Universality of Wigner Matrices,’ he proposed a solution for one of the many unanswered problems in the field of random matrix theory that have existed for decades. The paper, co-authored with Professor Jun Yin at the University of Wisconsin – Madison, was published in the Duke Mathematical Journal in 2014. Professor Lee joined KAIST in 2010 after finishing his Ph.D. at Harvard University. He was named a ‘POSCI Science Fellow’ and received the ‘Young Scientist Award’ from the KMS in 2014.
2017.04.27 View 7665 -
Professor Jae Kyoung Kim Receives the 2017 HSFP Award
The Human Frontier Science Program (HSFP), one of the most competitive research grants in life sciences, has funded researchers worldwide across and beyond the field since 1990. Each year, the program selects a handful of recipients who push the envelope of basic research in biology to bring breakthroughs from novel approaches. Among its 7,000 recipients thus far, 26 scientists have received the Nobel Prize. For that reason, HSFP grants are often referred to as “Nobel Prize Grants.”
Professor Jae Kyoung Kim of the Mathematical Sciences Department at KAIST and his international collaborators, Professor Robert Havekes from the University of Groningen, the Netherlands, Professor Sara Aton from the University of Michigan in Ann Arbor, the United States, and Professor Matias Zurbriggen from the University of Düsseldorf, Germany, won the Young Investigator Grants of the 2017 HSFP.
The 30 winning teams of the 2017 competition (in 9 Young Investigator Grants and 21 Program Grants) went through a rigorous year-long review process from a total of 1,073 applications submitted from more than 60 countries around the world. Each winning team will receive financial support averaging 110,000-125,000 USD per year for three years.
Although Professor Kim was trained as a mathematician, he has extended his research focus into biological sciences and attempted to solve some of the most difficult problems in biology by employing mathematical theories and applications including nonlinear dynamics, stochastic process, singular perturbation, and parameter estimation.
The project that won the Young Investigator Grants was a study on how a molecular circadian clock may affect sleep-regulated neurophysiology in mammals. Physiological and metabolic processes such as sleep, blood pressure, and hormone secretion exhibit circadian rhythms in mammals. Professor Kim used mathematical modeling and analysis to explain that the mammalian circadian clock is a hierarchical system, in which the master clock in the superchiasmatic nucleus, a tiny region in the brain that controls circadian rhythms, functions as a pacemaker and synchronizer of peripheral clocks to generate coherent systematic rhythms throughout the body.
Professor Kim said, “The mechanisms of our neuronal and hormonal activities regulating many of our bodily functions over a 24-hour cycle are not yet fully known. We go to sleep every night, but do not really know how it affects our brain functions. I hope my experience in mathematics, along with insights from biologists, can find meaningful answers to some of today’s puzzling problems in biological sciences, for example, revealing the complexities of our brains and showing how they work.”
“In the meantime, I hope collaborations between the fields of mathematics and biology, as yet a rare phenomenon in the Korean scientific community, will become more popular in the near future.”
Professor Kim received his doctoral degree in Applied and Interdisciplinary Mathematics in 2013 from the University of Michigan and joined KAIST in 2015. He has published numerous articles in reputable science journals such as Science, Molecular Cell, Proceedings of the National Academy of Sciences, and Nature Communications.
Both the Program Grants and Young Investigator Grants support international teams with members from at least two countries for innovative and creative research. This year, the Program Grants were awarded to research topics ranging from the evolution of counting and the role of extracellular vesicles in breast cancer bone metastasis to the examination of obesity from a mechanobiological point of view.
The Young Investigator Grants are limited to teams that established their independent research within the last five years and received their doctoral degrees within the last decade. Besides Professor Kim’s study, such topics as the use of infrasound for navigation by seabirds and protein formation in photochemistry and photophysics were awarded in 2017.
Full lists of the 2017 HFSP winners are available at: http://www.hfsp.org/awardees/newly-awarded.
About the Human Frontier Science Program (HFSP):
The HFSP is a research funding program implemented by the International Human Frontier Science Program (HFSPO) based in Strasbourg, France. It promotes intercontinental collaboration and training in cutting-edge, interdisciplinary research specializing in life sciences. Founded in 1989, the HFSPO consists of the European Union and 14 other countries including the G7 nations and South Korea.
2017.03.21 View 9060 -
KAIST's Board of Trustees Reappoints Dr. Jang-Moo Lee as Chairman
Dr. Jang-Moo Lee, the incumbent Chairman of the KAIST Board of Trustees, has been re-elected to head the office. His term will begin from the date of approval by the Minister of Science, ICT and Future Planning of Korea and will last for three years.
Dr. Lee received his undergraduate and master’s degrees in mechanical engineering from Seoul National University. He later earned his doctoral degree in mechanical engineering from Iowa State University in the United States.
Joined the faculty of his alma mater in 1976, Dr. Lee held various posts within the university including the dean of the engineering college. He served as the president of the Association of Korean Engineering Colleges, the founding chairman of the Korea Evaluation Institute of Industrial Technology, the president of the Korean Society of Mechanical Engineers, the 24th president of Seoul National University, and the 13th president of the Korean Council for University Education. He now serves as the president of the National Science and Technology Council of Korea and the chairman of Climate Change Center’s Board of Directors.
Dr. Lee has received numerous honors and awards, among others, the Academic Award of the Korean Society of Mechanical Engineers (1985), the Order of Science and Technology Merit from the Korean government (2005), the National Academy of Sciences Award (2005), and the Order of Service Merit in Blue Stripes (2010) from the Korean government. He was also selected as the Alma Mater Proud from Kyunggi High School in 2011.
2016.12.15 View 3723 -
KAIST Ranked the World's Sixth Most Innovative University
KAIST took sixth place in the list of “The World’s Top 100 Most Innovative Universities.” Thomson Reuters released the list on September 28, 2016, which was based on the data compiled by its division of Intellectual Property & Science such as patent filings, number of research papers and their citations, and industry collaboration. American universities took ranks from first to fifth; KAIST was the only non-American university that ranked highest in the list. Stressing the importance of linking basic research with commercializing efforts, Thomson Reuters said, the listed universities were “doing the most to advance science, invent new technologies and help drive the global economy.”
For details, go to the link below:
Reuters Top 100: The World’s Most Innovative Universities-2016
September 28, 2016
http://www.reuters.com/article/amers-reuters-ranking-innovative-univers-idUSL2N1C406D
2016.09.29 View 5729