Intel
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Production of chemicals without petroleum
Systems metabolic engineering of microorganisms allows efficient production of natural and non-natural chemicals from renewable non-food biomass
In our everyday life, we use gasoline, diesel, plastics, rubbers, and numerous chemicals that are derived from fossil oil through petrochemical refinery processes. However, this is not sustainable due to the limited nature of fossil resources. Furthermore, our world is facing problems associated with climate change and other environmental problems due to the increasing use of fossil resources. One solution to address above problems is the use of renewable non-food biomass for the production of chemicals, fuels and materials through biorefineries. Microorganisms are used as biocatalysts for converting biomass to the products of interest. However, when microorganisms are isolated from nature, their efficiencies of producing our desired chemicals and materials are rather low. Metabolic engineering is thus performed to improve cellular characteristics to desired levels. Over the last decade, much advances have been made in systems biology that allows system-wide characterization of cellular networks, both qualitatively and quantitatively, followed by whole-cell level engineering based on these findings. Furthermore, rapid advances in synthetic biology allow design and synthesis of fine controlled metabolic and gene regulatory circuits. The strategies and methods of systems biology and synthetic biology are rapidly integrated with metabolic engineering, thus resulting in "systems metabolic engineering".
In the paper published online in Nature Chemical Biology on May 17, Professor Sang Yup Lee and his colleagues at the Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea present new general strategies of systems metabolic engineering for developing microorganisms for the production of natural and non-natural chemicals from renewable biomass. They first classified the chemicals to be produced into four categories based on whether they have thus far been identified to exist in nature (natural vs. nonnatural) and whether they can be produced by inherent pathways of microorganisms (inherent, noninherent, or created): natural-inherent, natural-noninherent, non-natural-noninherent, and non-natural-created ones. General strategies for systems metabolic engineering of microorganisms for the production of these chemicals using various tools and methods based on omics, genome-scale metabolic modeling and simulation, evolutionary engineering, synthetic biology are suggested with relevant examples. For the production of non-natural chemicals, strategies for the construction of synthetic metabolic pathways are also suggested. Having collected diverse tools and methods for systems metabolic engineering, authors also suggest how to use them and their possible limitations.
Professor Sang Yup Lee said "It is expected that increasing number of chemicals and materials will be produced through biorefineries. We are now equipped with new strategies for developing microbial strains that can produce our desired products at very high efficiencies, thus allowing cost competitiveness to those produced by petrochemical refineries."
Editor of Nature Chemical Biology, Dr. Catherine Goodman, said "It is exciting to see how quickly science is progressing in this field – ideas that used to be science fiction are taking shape in research labs and biorefineries. The article by Professor Lee and his colleagues not only highlights the most advanced techniques and strategies available, but offers critical advice to progress the field as a whole."
The works of Professor Lee have been supported by the Advanced Biomass Center and Intelligent Synthetic Biology Center of Global Frontier Program from the Korean Ministry of Education, Science and Technology through National Research Foundation.
Contact: Dr. Sang Yup Lee, Distinguished Professor and Dean, KAIST, Daejeon, Korea (leesy@kaist.ac.kr, +82-42-350-3930)
2012.05.23 View 13819 -
KAIST signs strategic partnership with Global Techlink
On April 5th, KAIST signed an official strategic partnership with Global Techlink (GTL), an IP total service company that specializes in international patents and the technology trade, regarding the commercialization of technology (Tech-biz) at KAIST’s Munji Campus.
Through this partnership, KAIST hopes to systematically manage not only patents and related technologies developed by the KAIST faculty, but also industrial developments based on business models.
Until now, KAIST has concentrated on using its own human resources to transfer its patents and technologies to domestic companies. However, this agreement with GTL allows KAIST to target overseas tech-biz markets.
GTL has agreed to help create, protect and strengthen patent rights stemming from KAIST’s research projects and ideas, as well as provide a unified management service extending from selling and licensing patents to venture incubation.
KAIST’s vice-president of research, Professor Paik Kyung-Wook said that “We should protect patents developed by talented students and use them in the market to generate profit, but the fact of the matter is that universities do not have the necessary man power or know-how to do so”. He emphasized that this partnership with GTL will accelerate the global commercialization of technological assets developed by KAIST professors, students and researchers.
Mr. Kim Jong-hyun, the president of Global Techlink, announced that GTL will provide KAIST’s outstanding intellectual property with a customized total consulting service based on the world’s largest and best technology database, which it monopolizes, and various other services. Also, using its network with global corporations and distributors, the veteran marketing specialists at GTL will support and carry out KAIST’s tech-biz, although the specifics are still being worked out.
2012.04.19 View 9197 -
KAIST placed the 5th in top 50 global universities for international patent applications
New York Times released an article, dated March 19, 2012, on the statistics of international patent applications filed by global universities during 2011, and with 103 applications published, KAIST was listed the fifth among the top 50 universities, right behind four US universities: University of California (277), the Massachusetts Institute of Technology (179), the University of Texas System (127), and Johns Hopkins University (111). A total of seven Korean universities including KAIST made the top 50 list. For the article, please check the link below:
New York Times, March 19, 2012
“U.S. Universities Retain Lead in Patent Applications”
By Christopher F. Schuetze
http://www.nytimes.com/2012/03/19/world/asia/us-universities-retain-lead-in-patent-applications.html
In addition, for the press release by the World Intellectual Property Organization, the UN agency responsible for the Patent Cooperation Treaty, on international patent filings in 2011, please click the following link:
“International Patent Filings Set new Record in 2011”
http://www.wipo.int/pressroom/en/articles/2012/article_0001.html
2012.03.21 View 10158
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Distinguished Professor Sang-Yeop Lee gave keynote speech in '2011 China Bio-Refinery Summit'
Distinguished Professor Sang-Yeop Lee gave keynote speech in ‘2011 China Bio-Refinery Summit’ held in Chang’an, Beijing
Professor Lee gave a lecture on the vitalization strategy of ‘Bio-Refinery’, which is ‘A bio-based chemical industry to replace fossil fuel-based petro chemistry.
Professor Lee, insisted that for the successful construction of ‘Bio-Refinery’, there should be innovation in all value chain of biomass; biomass producer, bio-refinery business, consumer, government, etc. ▲Securement and distribution of Biomass ▲Development of strain and process for fermentation separation to effectively change biomass into chemical substance and fuel ▲Optimization of transportation and marketing.
During this summit, high-ranking government officials in politics and economics, executives of multicultural and Chinese business participated. From Korea, Do-Young Seung of Manager of technology research of GS and Hang-Deok Roh of laboratory chief of SK Chemical participated as panelist.
World Economy Forum, the gathering of leaders and experts in politics, economics, and policy created a ‘Global Agenda Council’ to find solutions on the issue of ‘sustainable growth of environment of the Earth and humanity’. Professor Lee is the chairperson of ‘Emerging Technologies Global Agenda Council (GAC)’ of Word Economy Forum.
Professor Lee, founder of ‘Systems Metabolic Engineering’, has made remarkable achievements world-wide, including a technology that manipulates metabolic circuit of microorganisms to purify various crude-originated chemical substances into environmentally friendly substances.
Currently, he is working on Systems biology research business in Ministry of Education, Science and Technology, Global Frontier Biomass business, Global Frontier Intelligent Bio-system construction and composition, to make progress in metabolic engineering which is essential for the bio-chemical industry.
2012.03.06 View 12535
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Golfzon, makes donation of "Faculty Club" to KAIST for interactions
Golfzon donates "Faculty Club" for increased interaction and communication among professors.
The Opening Ceremony was held with about a hundred executives including President Nam-Pyo Seo and Young-Chan Kim of Chairman of Golfzon Corp in attendance.
The "Faculty Club" will increase the opportunity for communication amongst professors, thereby creating intellectuals values with interaction.
Expanding from the existing banquet hall, Faculty Club is a multi-purpose meeting space including; large scale banquet hall, meeting room, resting room and screen golf club.
Young-Chan Kim, president of Golfzon Corp. said "We are putting to practice our management philosophy, "Sharing and caring"." And commented that "we hope the faculty club to be a place where the members of KAIST actively communicate and exchange ideas.”
President Seo commented, "We really appreciate for the special love and care towards KAIST which would create the opportunity for communication and harmony.” And that “it will be a precious place for it will foster the creation of ideas.”
Meanwhile, Golfzon is the number one screen golf business went public on KOSDAQ, May 2011, it first move in KAIST Business Incubator in Novemeber 2000 and was grown as a star venture business through KAIST’s diverse supports and phased introduction to the market.
2012.03.06 View 10017
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Annual Future Knowledge Service International Symposium
Knowledge Service Research preparing for the future knowledge based society has been academically publicized.
The First Annual Future Knowledge Service International Symposium was held in COEX Grand Ball Room Hall by KAIST’s department of Knowledge Service Engineering.
Knowledge Service Engineering is a core component to the future knowledge based society and is the convergent result of decision making, recognition sciences, artificial intelligence, IT, and other knowledge management technologies from each of the industries. Therefore Knowledge Service Engineering will innovate the cooperation and communication between humans and machines thereby forming the center point of the development of knowledge society.
The symposium was attended by 9 important figures from domestic and foreign academia, government representative, and key figures from industries. The symposium was based around debates concerning the role of the Knowledge Service Engineering in the future knowledge based society.
The key note speaker was Chairman of Korea Science and Technology Information Research Institute Park Young Suh and the theme of the speech was ‘Change in Information Environment and Knowledge Service’.
Director of National IT Industry Promotion Agency Kang Hyun Gu gave a lecture on the topic of ‘Important Knowledge Service Policies by National IT Industry Promotion Agency’. And from industry experts, Bradley K. Jensen (Manager of Microsoft Industry-Education Cooperation), Lee Kang Yoon (Research Director at IBM), Choi Yoon Shik (Head of Asia Future Human Resource Institute) proposed a direction for research and gave their account on recent trends of knowledge service from the perspective of onsite experience.
Academic experts like Fred D. Davis (Professor at State University of Arkansas), Jussi Kantola (Professor at KAIST), Kim Young Gul (Professor at KAIST Management University), Yoon Wan Chul (Professor at KAIST Knowledge Service Engineering) gave the recent trends in academic research.
The symposium was held in 3 sessions: ▲Policy of Korean Government ▲Academic Research Trend ▲Recent Trend and Application.
More information can be found at http://kss.kaist.ac.kr
2012.01.31 View 9589
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Professor Lee Jae Kyu : Appointed Fellow at Association of Information Systems
Professor Lee Jae Kyu of the Graduate School of Information Media Management was made Fellow of the Association of Information Systems.
Professor Less was the Chief Editor of Electronic Commerce Research and Applications, Chairman of Asia Pacific Information System Symposium, and Chairman of Korea Academy of Management Information, in addition to Chairman of the Academy of Korea Intelligence Information System.
The ‘Electronic Commerce’ co-written by Professor Lee is being used as primary MBA textbook in many universities around the world.
Homepage : http://www.business.kaist.ac.kr/faculty/jklee/
2012.01.31 View 9390
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10th Annual POSTECH-KAIST Competition: 'Revenge of the Blue Dragon'
KAIST is out for revenge after losing last year in the POSTECH-KAIST Annual Competition, a college rivalry between the two science and technology schools. The competition was held over two days, 23rd and 24th of September and involved 2,000 students from the two universities.
The POSTECH-KAIST Competition, also known as ‘Science War,’ is an annual event which started in 2002 to encourage active interaction between the two universities and increase public interest in science and technology education. The 2011 Competition marked the 10th competition as the 2009 competition was cancelled due to “swine influenza.”
The Competition is held every mid-September, and the title of the competition depends on the venue; the name of the host university is marked last by convention, hence the 2011 Science War was known as ‘POSTECH-KAIST Competition’ since the competition was held in KAIST.
The competition is composed of Hacking Competition, Science Trivia, Artificial Intelligence Programming Contest, StarCraft, Soccer, Baseball, and Basketball.
800 points are up for grabs, and the university with the most points wins. Both universities have won four times and lost four times and therefore promises to be a mouthwatering encounter this year.
Apart from the various competitions, interaction between clubs, cheerleading performances, and congratulatory concert (Dynamic Duo) were prepared. In addition, a beer party was hosted from 11pm of the first day of the competition to 2am the following day which brought students from the two universities closer together.
President Seo Nam Pyo of KAIST commented, “I am very happy that the two universities at the forefront of Korean Science and Technology can come together to interact and compete wholeheartedly through the 10th POSTECH-KAIST Competition” and that, “I hope that the students can exhibit the skills and ability that they have practiced hard on and uphold the proud history and tradition of KAIST.”
All games can be viewed at http://voki.kaist.ac.kr after the end of the Competition.
2011.09.26 View 8514 -
Professor Kim Seung Woo and Professor Ko Kyu Young Receive the 7th Gyeong Am Scholar Awards.
Professors Kim Seung Woo and Ko Kyu Young of KAIST were named the winners for the 7th Gyeong Am Scholar Awards.
The award winners are: Professor Ko Kyu Young of KAIST in the Biological Sciences category, Professor Kim Seung Woo of KAIST in the Engineering category, Professor Kim Young Shik of Seoul National University and Professor Kil Hui Seoung of Sogang University in the Humanities category, and Professor Hong Byoung Hee of Seoul National University in the Natural Sciences category.
In the Liberal Arts category leader of Universal Ballet Company Moon Hoon Sook was chosen, and the Special Achievement Award was given to Historian Dr. Park Myoung Sun. Professor Ko discovered that it is Angionpoietin-1 that induces the growth of new blood vessels and thus made a significant contribution to the field of blood vessel formation, immune mechanism, and causes of cancer spread.
Professor Kim developed a mini extreme ultra violet laser light source using the resonance principles of plasmon and made a great contribution in the acquiring of core technologies and its industrial commercialization in the field of super precise optical instruments.
Gyeong Am Education and Culture Foundation was founded by the Chairman of Tae Yang Group, Song Geum Jo who had donated his entire fortune amounting to 100billion Korean Won to society by creating a public foundation aimed at encouraging advancements in learning, training of experts, and cultural developments for the betterment of Korea.
The Gyeong Am Scholar Awards was established in 2005 and recognizes those scholars and artists who are making significant contributions in the frontlines of society.
The awards ceremony is to be held at Busan on the 4th of November, three thirty in the afternoon and the winner of each category is to receive 100mil Korean Won in prize money with a commemorative plaque.
2011.09.26 View 11206 -
KAIST Began to Operate 20 Specialized Patent Offices
KAIST’s Industry-University Collaboration Team started the operation of 20 specialized patent offices in order to improve the efficiency and specialty of patenting and commercialization of research results of KAIST. With the start of the operation of the patent offices, KAIST now has laid the groundwork for creating patent rights and improved patent use through improving services for technology developers and inventors.
The patent offices will offer various types of support related to patent rights and technology transfer by providing services such as interviews with inventors, preliminary reviews of technologies, and evaluations to find the invented technology patents worthwhile.
KAIST overwhelmingly outpaced other universities in the nation and ranked the “number one research university” in patent ownerships. According to the Korean Intellectual Property Office that investigated the number of patents domestic universities had acquired over the period of 5 years from 2006 to 2010, KAIST had 4,403 patents and was named the first in the fields of information and communication, electric materials and semiconductors, electronic circuit, automobile, and inorganic chemistry.
2011.09.20 View 7316 -
Scientists develop highly efficient industrial catalyst
http://english.yonhapnews.co.kr/business/2011/07/14/48/0501000000AEN20110714009600320F.HTML
SEOUL, July 15 (Yonhap) -- South Korean scientists said Friday that they have developed a highly efficient nanoporous industrial catalyst that can have a considerable impact on chemical and oil-refining sectors.
The team of scientists led by Ryoo Ryong, a chemistry professor at the Korea Advanced Institute of Science and Technology (KAIST), said the solid zeolite compound developed in the laboratory has a reaction speed five to 10 times faster than that of conventional materials.
Zeolite, which is made from silica and aluminium, is frequently used as an absorbent, water purifier and in nuclear reprocessing, although it is mainly employed in the chemical industry.
The annual size of the zeolite market is estimated at US$2.5 billion with output using the material topping $30 billion. At present, 41 percent of all catalysts used in the chemical sector are nano-scale zeolite materials.
The KAIST team said that because the new zeolite is made up of different sized pores, the material can be used as a catalyst when existing materials are unable to act as a changing agent.
"Existing zeolites only have pores under 1 nanometer in diameter, but the new material has holes that range from 1 nanometer to 3.5 nanometers, which are all arranged in a regular honeycomb arrangement," Ryoo said. A nanometer is one-billionth of a meter.
He said the ability to have both micro- and meso-sized pores is key to the faster reaction speed that is an integral part of raising efficiency. The South Korean researchers used a so-called surfactant process to make the different sizes of pores.
The development is a breakthrough because researchers and companies such as Exxon Mobil Corp. have been trying to build zeolite with different sizes of pores for the past two decades without making serious headway. There are more than 200 different types of zeolites in the world.
Ryoo, who received funding from the government, has requested intellectual property rights for the discovery, which has been published in the latest issue of Science magazine. He also developed another zeolite in the past that can transform methanol to gasoline up to 10 times more efficiently than existing catalysts.
Exxon Mobil has expressed interest in the two zeolites made by Ryoo"s team. Undisclosed South Korean petrochemical companies have also made inquiries that may lead to commercial development in the future.
"There are some technical issues to resolve, mainly related with mass production and stability," the scientist said.
He said full-fledge production will be determined by how much companies are willing to spend on research to speed up development that can bring down overall production costs.
The KAIST team said it took two years to make the new zeolite, which can be custom made to meet specific needs.
(END)
2011.07.15 View 12729
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KAIST Tops Patent List Among Domestic Universities, Chosun Ilbo, July 5, 2011
According to the Korean Intellectual Property Office, KAIST took the first place among the universities in Korea registering patents from 2006 to 2010. For the article from Chosun Ilbo, please go to the below link:
http://english.chosun.com/site/data/html_dir/2011/07/05/2011070500743.html
2011.07.05 View 10524