Research
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First Annual CanSat Idea Exhibition held
The Ministry of Education, Science, and Technology held the ‘CanSat’ Exhibition in order to increase interest and understanding of satellites in primary, secondary, and high school level students.
The exhibition, hosted by KAIST Satellite Research Center and funded by Korea Aerospace Institute, was held in SaeJeong City.
90 primary, secondary school teams, 57 high school teams, and 14 university teams submitted their applications for participation. Of these teams 20 primary, secondary school teams, 5 high school teams, and 5 university teams were selected after thorough document valuation and presentation assessment.
The 20 primary, secondary school teams participated in the science camp to gain firsthand experience in the construction and launch of a simple satellite system.
The high school and university teams were evaluated by the level of completion of the task given and the level of creativity involved.
The CanSat Exhibition has been held in aerospace powerhouses and this was the first time such an exhibition was held in Korea.
2012.08.21 View 9332 -
Systems biology demystifies the resistance mechanism of targeted cancer medication
Korean researchers have found the fundamental resistance mechanism of the MEK inhibitor, a recently highlighted chemotherapy method, laying the foundation for future research on overcoming cancer drug resistance and improving cancer survival rates. This research is meaningful because it was conducted through systems biology, a fusion of IT and biotechnology.
The research was conducted by Professor Gwang hyun Cho’s team from the Department of Biology at KAIST and was supported by the Ministry of Education, Science and Technology and the National Research Foundation of Korea.
The research was published as the cover paper for the June edition of the Journal of Molecular Cell Biology (Title: The cross regulation between ERK and PI3K signaling pathways determines the tumoricidal efficacy of MEK inhibitor).
Targeted anticancer medication targets certain molecules in the signaling pathway of the tumor cell and not only has fewer side effects than pre-existing anticancer medication, but also has high clinical efficacy. The technology also allows the creation of personalized medication and has been widely praised by scientists worldwide.
However, resistances to the targeted medication have often been found before or during the clinical stage, eventually causing the medications to fail to reach the drug development stage. Moreover, even if the drug is effective, the survival rate is low and the redevelopment rate is high.
An active pathway in most tumor cells is the ERK (Extracellular signal-regulated kinases) signaling pathway. This pathway is especially important in the development of skin cancer or thyroid cancer, which are developed by the mutation of the BRAF gene inside the path. In these cases, the MEK (Extracellular signal-regulated kinases) inhibitor is an effective treatment because it targets the pathway itself. However, the built-up resistance to the inhibitor commonly leads to the redevelopment of cancer.
Professor Cho’s research team used large scale computer simulations to analyze the fundamental resistance mechanism of the MEK inhibitor and used molecular cell biological experiments as well as bio-imaging* techniques to verify the results.
* Bio-imaging: Checking biological phenomena at the cellular and molecular levels using imagery
The research team used different mutational variables, which revealed that the use of the MEK inhibitor reduced the transmission of the ERK signal but led to the activation of another signaling pathway (the PI3K signaling pathway), reducing the effectiveness of the medication. Professor Cho’s team also found that this response originated from the complex interaction between the signaling matter as well as the feedback network structure, suggesting that the mix of the MEK inhibitor with other drugs could improve the effects of the targeted anticancer medication.
Professor Cho stated that this research was the first of its kind to examine the drug resistivity against the MEK inhibitor at the systematic dimension and showed how the effects of drugs on the signaling pathways of cells could be predicted using computer simulation. It also showed how basic research on signaling networks can be applied to clinical drug use, successfully suggesting a new research platform on overcoming resistance to targeting medication using its fundamental mechanism.
2012.07.06 View 11944
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The hereditary factor of autism revealed
Korean researchers have successfully investigated the causes and hereditary factors for autistic behavior and proposed a new treatment method with fewer side effects.
This research was jointly supported by the Ministry of Education, Science and Technology and the National Research Foundation as part of the Leading Researcher and Science Research Center Program
The research findings were publishing in the June edition of Nature magazine and will also be introduced in the July edition of Nature Reviews Drug Discovery, under the title ‘Autistic-like social behavior in Shank2-mutant mice improved by restoring NMDA receptor function’.
The research team found that lack of Shank2 genes in mice, which are responsible for the production of synapse proteins, caused autistic-like behavior. The results strongly suggested that the Shank2 gene was linked to autistic behavior and that Shank2 deficiency induced autistic behaviors.
Autism is a neural development disorder characterized by impaired social interaction, repetitive behavior, mental retardation, anxiety and hyperactivity. Around 100 million people worldwide display symptoms of autistic behavior. Recent studies conducted by the University of Washington revealed that 1 out of 3 young adults who display autistic behavior do not fit into the workplace or get accepted to college, a much higher rate than any other disorder. However, an effective cure has not yet been developed and current treatments are limited to reducing repetitive behavior.
The research team confirmed autistic-like social behavior in mice without the Shank2 genes and that the mice had decreased levels of neurotransmission in the NMDA receptor. The mice also showed damaged synaptic plasticity* in the hippocampus**.
* Plasticity: ability of the connectionbetween two neurons to change in strength in response to transmission of information
**Hippocampus: part of the brain responsible for short-term and long-term memory as well as spatial navigation.
The research team also found out that, to restore the function of the NMDA receptor, the passive stimulation of certain receptors, such as the mGLuR5, yielded better treatment results than the direct stimulation of the NMDA. This greatly reduces the side effects associated with the direct stimulation of receptors, resulting in a more effective treatment method.
This research successfully investigated the function of the Shank2 gene in the nerve tissue and showed how the reduced function of the NMDA receptor, due to the lack of the gene, resulted in autistic behavior. It also provided new possibilities for the treatment of autistic behavior and impaired social interaction
2012.06.24 View 12449
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KAIST hosts the first Can Satellite (Cansat) competition
Figure: The cansat is sent up into the air using a balloon and then separated at a certain height. The cansat slowly descends and sends terrestrial observation or atmospheric information back to earth.
KAIST will host the first ever Cansat Competition Korea, in which students from different age groups can participate in building and testing the performance of their custom satellites.
The Satellite Technology Research Center (SaTReC) at KAIST announced that it will take applications for the Cansat Competition Korea until May 25th. A cansat is a can-sized educational satellite that contains the basic elements of a real satellite. It is fired up to a few hundred meters in the air using balloons or small rockets and then separated like a real satellite, collecting data and sending the information back to earth. Cansat competitions are regularly held in the United States or Europe, where they have advanced space development programs, but this is the first time this competition will be held in Korea.
The competition caters to different age groups through a cansat experience science camp for elementary and middle school students and a cansat competition for high school and college students.
The science camp will be held from August 7th to 9th at KAIST and Sejong City and will include satellite education, visits to space development centers (KAIST Satellite Technology Research Center and the Korea Aerospace Research Institute), hand-on experience with basic cansat kits, and other various programs.
The science camp will consist of a maximum of 20 teams comprised of students from fifth to ninth grade. Each team will have an advisory teacher and 3 to 4 students and can apply for the competition at no cost.
The cansat competition will test high school and college students on their personally designed and built can satellites along with the creativity of their mission and developmental outcome.
The preliminary review will choose a maximum of 15 teams, while the secondary review will select the 5 teams that will make the final competition based on their design presentation. On August 9th, these 5 teams will be evaluated on their technical ability, mission capacity and presentation skills. The winning team will be given the KAIST presidential award along with a trophy and prize money.
Doctor Park from KAIST SaTReC explained that countries with advanced space technology actively support cansat competitions to expand the base of the field. He emphasized Korea’s need for regular cansat competitions to actively promote potential space researchers.
More information on the competition can be found on the homepage (http://cansat.kaist.ac.kr) or at the KAIST SaTReC (042-350-8613~4)
2012.05.14 View 12229 -
The output of terahertz waves enhanced by KAIST team
KAIST researchers have greatly improved the output of terahertz waves, the blue ocean of the optics world. This technology is expected to be applied to portable X-ray cameras, small bio-diagnostic systems, and in many other devices.
Professor Ki-Hun Jeong"s research team from the Department of Bio and Brain Engineering used optical nano-antenna technology to increase the output of terahertz waves by three times.
Terahertz waves are electromagnetic waves with frequencies between 100GHz to 30THz. They are produced when a femtosecond (10^-15 s) pulse laser is shone on a semiconductor substrate with photoconduction antennas, causing a photocurrent pulse of one picosecond (10^-12 s). Their long wavelengths, in comparison to visible light and infrared rays, give terahertz waves a high penetration power with less energy than X-rays, making them less harmful to humans.
These qualities allow us to see through objects, just as X-rays do, but because terahertz waves absorb certain frequencies, we can detect hidden explosives or drugs, which was not possible with X-rays. We can even identify fake drugs. Furthermore, using the spectral information, we can analyze a material"s innate qualities without chemical processing, making it possible to identify skin diseases without harming the body. However, the output was not sufficient to be used in biosensors and other applications.
Prof. Jeong"s team added optical nano-antennas, made from gold nano-rods, in between the photoconduction antennas and optimized the structure. This resulted in nanoplasmonic resonance in the photoconduction substrate, increasing the degree of integration of the photocurrent pulse and resulting in a three times larger output.
Hence, it is not only possible to see through objects more clearly, but it is also possible to analyze components without a biopsy.
Professor Jeong explained, "This technology, coupled with the miniaturization of terahertz devices, can be applied to endoscopes to detect early epithelial cancer" and that he will focus on creating and commercializing these biosensor systems.
This research was published in the March issue of the international nanotechnology journal ACS Nano and was funded by the Korea Evaluation Institute of Industrial Technology and the National Research Foundation of Korea.
Figure: Mimetic diagram of a THz generator with nano-antennas
2012.04.29 View 12815 -
Undergraduate Research Program, Putting Wings on Undergraduate"s Dreams
KAIST held the 2011 URP Research Result Presentation in the Creative Learning Center on the 17th. Four students Jae Gyung Seo, Tran An Tu, Gun Sik Ahn, and Gyung Ryul Bong have been chosen as the grand prize winners.
The grand prize winners receive 3.5million won to allow them to participate in an international academic conference. The URP program is the first of its kind in Korea and has been benchmarked from MIT’s UROP(Undergraduate Research Opportunity Program).
The school selects 60 individual and 20 team research projects for undergraduates twice a year and provides mentorship as well as financial support.
Students signing up for the URP are to submit research plans and are then chosen through looking at these documents. Students receive 6 months of research funds and are to work under a professor and TA in groups of 2 to 3 or individually.
The URP program which is funded by the Ministry of Science and Technology has settled in successfully and has been expanded to the entire country.
The head of the R&D team, Yong Jae Sung, stated, “The number of research plans have been 154 in 2008, 189 in 2009, 220 and 251 respectively in 2010 and 2011. It’s continuously rising. And over 80% of responses on satisfaction surveys have replied that students were satisfied. It is very popular among undergraduates.“
Student Sang Yeon Cho has also said, “I was able to research on everything that I wanted under funding of the school and the guidance of renowned professors thanks to the URP program.”
To Seul Gi Lee, a graduate student for the electrical engineering department who has developed the wearable sleeping pattern analysis system, URP is an especially special program.
She said, “I successfully researched in the wearable health care field as my URP research material in 2006 when I was in my junior year. I made second place. After this, I have continued my research in this field on SoC(System on Chip) for wearable healthcare in graduate school and will be receiving my doctorate degree on the 24h.”
Doctor Seul Gi Lee has been recognized in the field of wearable healthcare for her research and has been hired as a researcher in the Holst Centre which is a national research center funded by the Netherlands’ government. She will continue to research on measuring and analyzing biological readings.
2012.04.04 View 10613
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Inexpensive Separation Method of Graphene Developed
The problem with commercializing graphene that is synthesized onto metals over a wide area is that it can not be separated from the metal. However, a groundbreaking separation technology which is both cheap and environment friendly has been developed.
Prof. Taek soo Kim and Prof. Byung Jin Cho"s research teams have conducted this research under the support of the Global Frontier program and Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research results have been posted on the online news flash of Nano Letters on februrary 29th. (Thesis title: Direct Measurement of Adhesion Energy of Monolayer Graphene As-Grown on Copper and Its Application to Renewable Transfer Process)
The research has generated exact results on the interfacial adhesive energy of graphene and its surface material for the first time. Through this, the catalyst metal are no longer to be used just once, but will be used for an infinite number of times, thereby being ecofriendly and efficient.
Wide area graphine synthesized onto the catalyst meatal are used in various ways such as for display and for solar cells. There has been much research going on in this field. However, in order to use this wide area graphene, the graphene must be removed from the catalyst metal without damage.
Until now, the metal had been melted away through the use of chemical substances in order to separate the graphene. However, this method has been very problematic. The metal can not be reused, the costs are very high, much harmful wastes were created in the process of melting the metals, and the process was very complicated.
The research teams of Professors Taek Su Kim and Byung Jin Cho measured the interfacial adhesive energy of the synthesized graphene and learned that it could be easily removed.
Also, the mechanically removed graphene was successfully used in creating molecular electronic devices directly. This has thus innovatively shortened the graphene manufacturing process. Also, it has been confirmed that the metalic board can be reused multiple times after the graphene is removed. A new, ecofriendly and cost friendly method of graphene manufacturing has been paved.
Through this discovery, it is expected that graphene will become easier to manufacture and that the period til the commercialization date of graphene will therefore be greatly reduced
Prof. Cho stated " This reserach has much academical meaning significance in that it has successfully defined the surfacial adhesive energy between the graphene and its catalyst material and it should receive much attention in that it solved the largest technical problem involved in the production of graphene.
2012.04.04 View 14275
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New Era for Measuring Ultra Fast Phenomena: Atto Science Era
Domestic researchers successfully measured the exact status of the rapidly changing Helium atom using an atto second pulse. Thanks to this discovery, many ultrafast phenomena in nature can now be precisely measured. This will lead to an opening of a new "Atto Science" era.
Prof. Nam Chang Hee led this research team and Ph.d Kim Kyung Taek and Prof. Choi Nak Ryul also participated in this research. They have conducted the research under the support of the Researcher Support Program initiated by The Ministry of Education and Science and Korea Research Foundation. The research result was published in the prestigious journal "Physical Review Letters" on March 2nd. (Title: Amplitude and Phase Reconstruction of Electron Wave Packets for Probing Ultrafast Photoionization Dynamics)
Prof. Nam Chang Hee"s research team used atto second pulse to measure the ultrafast photoionization.
His team used atto second X-ray pulse and femto second laser pulse to photoionize Helium atoms, and measure the wave speed of the produced electron to closely investigate the ultrafast photoionization process.
Atom"s photoionization measurement using an atto second pulse was possible using the research team"s high-energy femto second laser and high-performance photo ion measurement device. This research team succeeded in producing the shortest 60 atto second pulse in the world using high-harmonic waves.
The research team used high-power femto second laser to produce atto second high-harmonic pulse from argon gas, used this to photoionize Helium atoms, and measured the ultrafast photoionization of the atoms.
Prof. Nam Chang Hee said, "This research precisely measured the exact status of rapidly changing Helium atoms. I am planning to research on measuring the ultrafast phenomena inside atoms and molecules and controlling the status of the atoms and molecules based on the research result."
2012.04.04 View 10819
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Professor Sang-Min Bae appears on EBS Global Theme Travel.
"We want to present "hope" by designing schools and homes for the third-world countries, while considering the culture of the nation.”
Professor Bae and his team went to Ethiopia, Africa, for "Design for Social Donation and Design Research for isolated third-world nations".
Professor Bae commented that, "We have visited for preparatory investigation, experiencing and investigating the life and cultures of the third-world nations in order to design schools and homes."
He continued, "From this visit, we want to develop adequate technology catered for the locals and create a design guideline." He added "We also want to propose a new model using design and technology that contributes to social welfare".
Meanwhile, EBS team accompanied to cover the report and was broadcasted through "EBS Global Theme Travel.
2012.03.06 View 8777
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Annual Future Knowledge Service International Symposium
Knowledge Service Research preparing for the future knowledge based society has been academically publicized.
The First Annual Future Knowledge Service International Symposium was held in COEX Grand Ball Room Hall by KAIST’s department of Knowledge Service Engineering.
Knowledge Service Engineering is a core component to the future knowledge based society and is the convergent result of decision making, recognition sciences, artificial intelligence, IT, and other knowledge management technologies from each of the industries. Therefore Knowledge Service Engineering will innovate the cooperation and communication between humans and machines thereby forming the center point of the development of knowledge society.
The symposium was attended by 9 important figures from domestic and foreign academia, government representative, and key figures from industries. The symposium was based around debates concerning the role of the Knowledge Service Engineering in the future knowledge based society.
The key note speaker was Chairman of Korea Science and Technology Information Research Institute Park Young Suh and the theme of the speech was ‘Change in Information Environment and Knowledge Service’.
Director of National IT Industry Promotion Agency Kang Hyun Gu gave a lecture on the topic of ‘Important Knowledge Service Policies by National IT Industry Promotion Agency’. And from industry experts, Bradley K. Jensen (Manager of Microsoft Industry-Education Cooperation), Lee Kang Yoon (Research Director at IBM), Choi Yoon Shik (Head of Asia Future Human Resource Institute) proposed a direction for research and gave their account on recent trends of knowledge service from the perspective of onsite experience.
Academic experts like Fred D. Davis (Professor at State University of Arkansas), Jussi Kantola (Professor at KAIST), Kim Young Gul (Professor at KAIST Management University), Yoon Wan Chul (Professor at KAIST Knowledge Service Engineering) gave the recent trends in academic research.
The symposium was held in 3 sessions: ▲Policy of Korean Government ▲Academic Research Trend ▲Recent Trend and Application.
More information can be found at http://kss.kaist.ac.kr
2012.01.31 View 9416
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Quantum Mechanical Calculation Theory Developed
An Electron Density Functional Calculation Theory, based on the widely used quantum mechanical principles and yet accurate and with shortened calculation period, was developed by Korean research team.
*Electron Density Functional Calculation Theory: Theory that proves that it is possible to calculate energy and properties with only simple wave equations and electron densities.
The research was conducted by Professor Jeong Yoo Sung (Graduate School of EEWS) and Professor William Goddard with support from WCU Foster Project initiated by Ministry of Education, Science and Technology and Korea Research Foundation. The result was published in the Proceedings of the National Academy of Sciences Journal.
The research team corrected the error when performing quantum calculations that arises from the length of calculation time and incorrect assumptions and developed a theory and algorithm that is more accurate and faster. The use of wave equations in quantum mechanical calculations results in high accuracy but there is a rapid increase in calculation time and is therefore difficult to implement in large molecules with hundreds, or thousands of atoms. By implementing a low electron density variable with relatively less calculation work, the size of calculable molecule increases but the accuracy decreases.
The team focused on the interaction between electrons with different spins to improve upon the speed of calculation in the conventional accurate calculation. The team used the fact that the interaction between electrons with different spins increases as it comes closer together in accordance with the Pauli’s Exclusion Principle.
In addition the interaction between electrons are local and therefore can ignore the interactions between far away electrons and still get the total energy value. The team also took advantage of this fact and developed the algorithm that decreased calculation time hundredth fold.
Professor Jeong commented that, “So far most of the domestic achievements were made by focusing on integrative researches by calculation science and material design communities but these involved short time frames. In areas that required lengthy time frames like fundamentals and software development, there was no competitive advantage. However this research is significant in that a superior solution was developed domestically”.
2012.01.31 View 11625
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'Scientist-Engineer of the Month' for December: Professor Choi Joon Ho
Professor Choi Joon Ho (department of Biological Sciences) was made ‘Scientist-Engineer of December’ for his discovery of new gene (twenty-four) that helps biorhythm and proving that this gene helps control biorhythm.
Professor Choi published 100 dissertations over the past 25 years and made significant advancements in the field of molecular virus and neurobiology.
In 1995 Professor Choi uncovered the fact that the NS3 protein in C type hepatitis function as RNA helicase thereby opening the path to developing a cure for C type hepatitis; this is an international patent with Chiron corporation. The result was published in Biochemical and Biophysical Research Communications Journal and was the most domestically referred to dissertation in biological sciences in 1999.
In addition Professor Choi published in Nature magazine in 1999, a dissertation that uncovered the fact that the DNA of papillomar virus has another protein (hSNF5) that direct it apart from ordinary proteins.
In 2000~2005 Professor Choi published many dissertations in journals like Immunity, Cancer Research, Molecular and Cellular Biology, Oncogene, Journal of Virology, and etc.
Professor Choi screened over 10,000 species of pomace fly mutations and discovered the twenty-four gene that affects the biorhythm of pomace flies. He analyzed this gene further and found a new function that was different from known biorhythm mechanisms.
This research allowed a better understanding of biological clock of pomace flies and therefore was another step towards better understanding the control mechanism of human biological clock.
2012.01.31 View 9742