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KAIST, NTU, and Technion Collaborate for Research in Emerging Fields
KAIST, Nanyang Technological University (NTU) of Singapore, and Technion of Israel signed an agreement on April 11, 2016 in Seoul to create a five-year joint research program for some of the most innovative and entrepreneurial areas: robotics, medical technologies, satellites, materials science and engineering, and entrepreneurship. Under the agreement, the universities will also offer dual degree opportunities, exchange visits, and internships.
In the picture from the left, Bertil Andersson of NTU, Sung-Mo Kang of KAIST, and Peretz Lavie of Technion hold the signed memorandum of understanding.
2016.04.14 View 9927 -
Non-Natural Biomedical Polymers Produced from Microorganisms
KAIST researchers have developed metabolically engineered Escherichia coli strains to synthesize non-natural, biomedically important polymers including poly(lactate-co-glycolate) (PLGA), previously considered impossible to obtain from biobased materials.
Renewable non-food biomass could potentially replace petrochemical raw materials to produce energy sources, useful chemicals, or a vast array of petroleum-based end products such as plastics, lubricants, paints, fertilizers, and vitamin capsules. In recent years, biorefineries which transform non-edible biomass into fuel, heat, power, chemicals, and materials have received a great deal of attention as a sustainable alternative to decreasing the reliance on fossil fuels.
A research team headed by Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at KAIST has established a biorefinery system to create non-natural polymers from natural sources, allowing various plastics to be made in an environmentally-friendly and sustainable manner. The research results were published online in Nature Biotechnology on March 7, 2016. The print version will be issued in April 2016.
The research team adopted a systems metabolic engineering approach to develop a microorganism that can produce diverse non-natural, biomedically important polymers and succeeded in synthesizing poly(lactate-co-glycolate) (PLGA), a copolymer of two different polymer monomers, lactic and glycolic acid. PLGA is biodegradable, biocompatible, and non-toxic, and has been widely used in biomedical and therapeutic applications such as surgical sutures, prosthetic devices, drug delivery, and tissue engineering.
Inspired by the biosynthesis process for polyhydroxyalkanoates (PHAs), biologically-derived polyesters produced in nature by the bacterial fermentation of sugar or lipids, the research team designed a metabolic pathway for the biosynthesis of PLGA through microbial fermentation directly from carbohydrates in Escherichia coli (E. coli) strains.
The team had previously reported a recombinant E. coli producing PLGA by using the glyoxylate shunt pathway for the generation of glycolate from glucose, which was disclosed in their patents KR10-1575585-0000 (filing date of March 11, 2011), US08883463 and JP5820363. However, they discovered that the polymer content and glycolate fraction of PLGA could not be significantly enhanced via further engineering techniques. Thus, in this research, the team introduced a heterologous pathway to produce glycolate from xylose and succeeded in developing the recombinant E. coli producing PLGA and various novel copolymers much more efficiently.
In order to produce PLGA by microbial fermentation directly from carbohydrates, the team incorporated external and engineered enzymes as catalysts to co-polymerize PLGA while establishing a few additional metabolic pathways for the biosynthesis to produce a range of different non-natural polymers, some for the first time. This bio-based synthetic process for PLGA and other polymers could substitute for the existing complicated chemical production that involves the preparation and purification of precursors, chemical polymerization processes, and the elimination of metal catalysts.
Professor Lee and his team performed in silico genome-scale metabolic simulations of the E. coli cell to predict and analyze changes in the metabolic fluxes of cells which were caused by the introduction of external metabolic pathways. Based on these results, genes are manipulated to optimize metabolic fluxes by eliminating the genes responsible for byproducts formation and enhancing the expression levels of certain genes, thereby achieving the effective production of target polymers as well as stimulating cell growth.
The team utilized the structural basis of broad substrate specificity of the key synthesizing enzyme, PHA synthase, to incorporate various co-monomers with main and side chains of different lengths. These monomers were produced inside the cell by metabolic engineering, and then copolymerized to improve the material properties of PLGA. As a result, a variety of PLGA copolymers with different monomer compositions such as the US Food and Drug Administration (FDA)-approved monomers, 3-hydroxyburate, 4-hydroxyburate, and 6-hydroxyhexanoate, were produced. Newly applied bioplastics such as 5-hydroxyvalerate and 2-hydroxyisovalerate were also made.
The team employed a systems metabolic engineering application which, according to the researchers, is the first successful example of biological production of PGLA and several novel copolymers from renewable biomass by one-step direct fermentation of metabolically engineered E.coli.
Professor Lee said, “We presented important findings that non-natural polymers, such as PLGA which is commonly used for drug delivery or biomedical devices, were produced by a metabolically engineered gut bacterium. Our research is meaningful in that it proposes a platform strategy in metabolic engineering, which can be further utilized in the development of numerous non-natural, useful polymers.”
Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning of Korea, who oversees the Technology Development Program to Solve Climate Change, said, “Professor Lee has led one of our research projects, the Systems Metabolic Engineering for Biorefineries, which began as part of the Ministry’s Technology Development Program to Solve Climate Change. He and his team have continuously achieved promising results and been attracting greater interest from the global scientific community. As climate change technology grows more important, this research on the biological production of non-natural, high value polymers will have a great impact on science and industry.”
The title of the research paper is “One-step Fermentative Production of Poly(lactate-co-glycolate) from Carbohydrates in Escherichia coli (DOI: 10.1038/nbt.3485).” The lead authors are So Young Choi, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at KAIST, and Si Jae Park, Assistant Professor of the Environmental Engineering and Energy Department at Myongji University. Won Jun Kim and Jung Eun Yang, both doctoral students in the Department of Chemical and Biomolecular Engineering at KAIST, also participated in the research.
This research was supported by the Technology Development Program to Solve Climate Change’s research project titled “Systems Metabolic Engineering for Biorefineries” from the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF-2012M1A2A2026556).
Figure: Production of PLGA and Other Non-Natural Copolymers
This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced a variety of PLGAs with different monomer compositions, proposing the chemosynthetic process of non-natural polymers from biomass. The non-natural polymer PLGA and its other copolymers, which were produced by engineered bacteria developed by taking a systems metabolic engineering approach, accumulate in granule forms within a cell.
2016.03.08 View 11073 -
Asia Pacific Biotech News' Special Coverage of Korean Biotechnology
The Asia Pacific Biotech News covered five major biotechnology research projects sponsored by the Korean government in the areas of biofuels, biomedicine, bio-nano healthcare, and biorefinery.
The Asia Pacific Biotech News (APBN), a monthly magazine based in Singapore, which offers comprehensive reports on the fields of pharmaceuticals, healthcare, and biotechnology, recently published a special feature on Korea’s biotechnology research and development (R&D) programs.
The magazine feature selected five research programs sponsored by the Korean government, which are either part of the Global Frontier or the Climate Change Technology Development Projects.
The programs are:
Systems Metabolic Engineering Research: Distinguished Professor Sang Yup Lee
of the Chemical and Biomolecular Engineering Department at the Korea Advanced
Institute of Science and Technology (KAIST) has been leading a research group to
develop biorefining technology using renewable non-food biomass to produce
chemicals, fuels, and materials that were largely drawn from fossil resources
through petrochemical refinery processes. Applying a systems metabolic
engineering approach, the group succeeded in modifying the metabolic pathways of
microorganisms. As a result, they produced, for the first time in the world,
engineered plastic raw materials and gasoline. The team also developed a technique
to produce butanol and succinic acid with a higher titer and yield using metabolically
engineered microorganisms.
Next-generation Biomass Research: Under the leadership of Professor Yong-
Keun Chang of the Chemical and Biomolecular Engineering Department at KAIST,
the research project, which belongs to the Global Frontier Project, develops biofuels
and bioproducts utilizing microalgae typically found in water and other marine
systems.
Convergence Research for Biomedicine: Professor Sung-Hoon Kim of Seoul
National University leads this project that develops targeted new drugs based on
convergence research strategies.
Bionano Healthcare Chip Research: Director Bong-Hyun Chung of the Korea
Research Institute of Bioscience and Biotechnology has integrated information and
communications technology, nanotechnology, and biotechnology to develop a
diagnostic kit that can screen toxic germs, virus, and toxic materials in a prompt
and accurate manner.
Biosynergy Research: Led by Professor Do-Hun Lee of the Bio and Brain
Engineering Department at KAIST, this research project develops new treatments
with a multi-target, multi-component approach in the context of systems biology
through an analysis of synergistic reactions between multi-compounds in traditional
East Asian medicine and human metabolites. In East Asian medicine, treatment and
caring of the human body are considered analogous to the politics of governing a
nation. Based on such system, the research focuses on designing a foundation for
the integration of traditional medicine with modern drug discovery and development.
Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning, Republic of Korea, who is responsible for the Global Frontier Program and the Technology to Solve Climate Change, said, “It is great to see that Asia Pacific Biotech News published an extensive coverage of Korea’s several key research programs on biotechnology as its first issue of this year. I am sure that these programs will lead to great outcomes to solve many worldwide pending issues including climate change and healthcare in the aging society.”
Professor Sang Yup Lee, who served as an editor of the feature, said, “At the request of the magazine, we have already published lead articles on our biotechnology research three times in the past in 2002, 2006, and 2011. I am pleased to see continued coverage of Korean biotechnology by the magazine because it recognizes the excellence of our research. Biotechnology has emerged as one of the strong fields that addresses important global issues such as climate change and sustainability.”
2016.02.04 View 11580 -
A Firefighter Drone That Flies and Crawls Up Walls
KAIST researchers developed a wall-climbing scout drone to fight fires in high-rises, finding the source of the fires and locating people trapped inside.
The 1974 American disaster film Towering Inferno depicted well the earnest struggles of firefighters engaged in ending a fire at a 138-story skyscraper. To this day, fires at high-rise buildings are considered one of the most dangerous disasters.
Skyscraper fires are particularly difficult to contain because of their ability to spread rapidly in high-occupant density spaces and the challenge of fighting fires in the buildings’ complex vertical structure. Accessibility to skyscrapers at the time of the fire is limited, and it is hard to assess the initial situation.
A research team at KAIST led by Professor Hyun Myung of the Civil and Environmental Engineering Department developed an unmanned aerial vehicle, named the Fireproof Aerial RObot System (FAROS), which detects fires in skyscrapers, searches the inside of the building, and transfers data in real time from fire scenes to the ground station.
As an extended version of Climbing Aerial RObot System (CAROS) that was created in 2014 by the research team, the FAROS can also fly and climb walls.
The FAROS, whose movements rely on a quadrotor system, can freely change its flight mode into a spider’s crawling on walls, and vice versa, facilitating unimpeded navigation in the labyrinth of narrow spaces filled with debris and rubble inside the blazing building.
The drone “estimates” its pose by utilizing a 2-D laser scanner, an altimeter, and an Inertia Measurement Unit sensor to navigate autonomously. With the localization result and using a thermal-imaging camera to recognize objects or people inside a building, the FAROS can also detect and find the fire-ignition point by employing dedicated image-processing technology.
The FAROS is fireproof and flame-retardant. The drone’s body is covered with aramid fibers to protect its electric and mechanical components from the direct effects of the flame. The aramid fiber skin also has a buffer of air underneath it, and a thermoelectric cooling system based on the Peltier effect to help maintain the air layer within a specific temperature range.
The research team demonstrated the feasibility of the localization system and wall-climbing mechanism in a smoky indoor environment. The fireproof test showed that the drone could endure the heat of over 1,000° Celsius from butane gas and ethanol aerosol flames for over one minute.
Professor Myung said, “As cities become more crowded with skyscrapers and super structures, fire incidents in these high-rise buildings are life-threatening massive disasters. The FAROS can be aptly deployed to the disaster site at an early stage of such incidents to minimize the damage and maximize the safety and efficiency of rescue mission.”
The research team has recently started to enhance the performance of the fireproof design for the exteroceptive sensors including a 2-D laser scanner and a thermal-imaging camera because those sensors could be more exposed to fire than other inside sensors and electric components.
This research was funded by the KAIST Initiative for Disaster Studies and the KAIST Institute.
YouTube link: https://youtu.be/gPNRZi0EPQw
Picture 1: Demonstration of Wall-climbing
The Fireproof Aerial RObot System (FAROS) is a wall-climbing scout drone developed to conduct explorations into the site of skyscraper fires. It has an ability to climb walls in smoky, narrow spaces inside buildings.
Figure 2: An Ability to Withstand Fires
The FAROS can endure the heat of over 1,000° Celsius from butane gas and ethanol aerosol flames for over one minute.
2016.01.20 View 14849 -
IdeasLab Presents Biotechnology Solutions for Aging Populations at 2016 Davos Forum
KAIST researchers will discuss how biological sciences and health technologies can address challenges and opportunities posed by aging populations in an era of increasing longevity.
Many countries around the world today are experiencing the rapid growth of aging populations, with a decline in fertility rate and longer life expectancy.
At this year's Annual Meeting of the World Economic Forum (a.k.a. Davos Forum) on January 20-23, 2016 in Davos-Klosters, Switzerland, four researchers in the field of biological sciences and biotechnology at the Korea Advanced Institute of Science and Technology (KAIST) will discuss the implications of an aging population and explore possible solutions to provide better health care services to the elderly.
KAIST will host an IdeasLab twice on the theme "Biotechnology Solutions for Ageing Populations" on January 21st and 23rd, respectively.
Professor Byung-Kwan Cho of the Biological Sciences Department will give a presentation on "Rejuvenation via the Microbiome," explaining how microorganisms in the human gut play an important role in preventing aging, or even rejuvenating it.
Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department will talk about "Traditional Medicine Reimagined through Modern Systems Biology." Professor Lee will introduce his research results published in Nature Biotechnology (March 6, 2015) and some more new results. He discovered the mechanisms of traditional oriental medicine's (TOM) efficacy by applying systems biology to study structural similarities between natural and nontoxic multi-compounds in the medicine and human metabolites. He will discuss TOM's multi-target approach, which is based on the synergistic combinations of multi-compounds to treat symptoms of a disease, can contribute to the development of new drugs, cosmetics, and nutrients.
Professor Youn-Kyung Lim of the Industrial Design Department will speak about a mobile and the Internet of Things-based health care service called "Dr. M" in her presentation on "Advanced Mobile Healthcare Systems."
Professor Daesoo Kim of the Biological Sciences Department will share his research on human's happiness and greed in the context of nueroscience and behavioral and biological sciences in a talk entitled "A Neural Switch for Being Happy with Less on a Crowded Planet."
KAIST has hosted IdeasLabs several times at the Summer Davos Forum in China, but this is the first time it will participate in the Davos Forum in January.
Professor Lee said, "Just like climate change, the issue of how to address aging populations has become a major global issue. We will share some exciting research results and hope to have in depth discussion on this issue with the leaders attending the Davos Forum. KAIST will engage actively in finding solutions that benefit not only Korea but also the international community."
2016.01.19 View 10307 -
Professor Duck-Joo Lee Receives the Achievement Award in the Asian-Australian Rotorcraft Forum 2015
Professor Duck-Joo Lee of the Aerospace Engineering Department at KAIST received the achievement award in ARF (Asian-Australian Rotorcraft Forum) 2015. In ARF, companies such as Bell Helicopter and Airbus Helicopter gather and share their technological discoveries.
Professor Lee was elected as Chairman of the first ARF to oversee the organization of its forum as well as exhibitions, and his effort towards advancing rotorcraft was recognized.
Professor Lee said, “I hope that research findings of many scholars will be applied to the domestic air transportation businesses.” He added, “More companies in the field should enter the global market.”
Professor Lee started his career as a researcher in NASA Ames Research Center. He is an expert in the fields of jet engines and aeroacoustics.
2015.12.08 View 6113 -
KAIST and the University of Minnesota-Twin Cities Partner for Research and Education Collaboration
President Steve Kang of KAIST and President Eric W. Kaler of the University of Minnesota-Twin Cities (United States) signed a memorandum of understanding to create exchange programs for students and faculty and to conduct joint research in the field of health and food. The following is an excerpt from President Kaler’s blog (https://storify.com/UMNstory/globalumn-hksk#edaadf) on his visit of KAIST on November 18, 2015:
A visit to the Korea Advanced Institute of Science and Technology
About 90 miles from Seoul—and more than that two-and-a-half-hours of a bus ride through the rugged early-morning traffic of South Korea’s capital city—sits Daejeon, Korea’s sixth largest city and home to KAIST, the Korea Advanced Institute of Science and Technology. Today, President Kaler and the small University of Minnesota delegation accompanying him visited what’s considered Korea’s MIT, a place focused on research and known to push the limits toward the future.
Fingernail heart monitors? Wireless anesthetic-monitoring devices?
KAIST is working on them.
The overlap of interests—from biomedical engineering to nanotechnology to robotics—between KAIST (pronounced “Kyst”) and the U are remarkable. Smartphone apps to monitor human health and GPS-driven robots to serve military interests or deliver packages were among the developing inventions that KAIST scientists showed to Kaler.
And even the personal relationships seem to illustrate the cliché of a small world and the natural affinity of Minnesota and KAIST.
KAIST’s President Sang Mo Kang was once the head of the University of Illinois’ department of electrical and computer engineering, and he and Kaler—a renowned chemical engineer before becoming the U’s president—hit it off … despite disagreeing about the potential outcome of Saturday’s Illinois-Gophers football game.
Accompanying Kaler on the day’s journey, meetings, and signing of a Memorandum of Understanding between the two schools to advance collaborations was U Associate Professor Sang Hyun Oh. Oh happens to be a physics graduate of this very KAIST and is now a rising star in Minnesota’s Department of Electrical and Computer Engineering.
The two sides agreed to focus on matching scholars on their respective campuses to discuss the sorts of research the two institutions can partner on. The idea of “Grand Challenges,” at the core of the U’s Twin Cities campus Strategic Plan, has fascinated Korean higher education leaders during Kaler’s weeklong visit, and KAIST’s leadership was interested in the health and food research, two U strengths.
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2015.12.04 View 7628 -
KAIST's Top 10 Contributions to Korea and the World
Established in 1971, the Korea Advanced Institute of Science and Technology (KAIST) started off as a relatively modest graduate school in a few disciplines in science and technology, but has gradually expanded into a full-fledged research university over the years.
From the beginning, KAIST was intended to offer an elite science education, setting it apart from other universities in Korea. A majority of its graduates have contributed to the development of, what the world now praises, Korean industry and economy, and have led the Korean scientific community for several decades. The university has also advanced the frontiers of knowledge, conducting the lion’s share of the nation’s private research and development in basic and applied science, leading to innovations and technologies essential to the growth of today’s Korea.
As it establishes international benchmarks of success, KAIST has acquired a global reputation for delivering the highest level of science and engineering education, while performing cutting-edge research and serving as a crucial driver to generate new knowledge and innovation beneficial not only to Korea but also to the world. The university has consistently ranked in the top 100 research universities for over more than a decade, according to the world university rankings published by international ranking institutions for higher education, among others, Quacquarelli Symonds and the Times Higher Education.
KAIST will mark its 45th anniversary next year. It plans to celebrate the anniversary, and here are some of the reasons why:
KAIST’s Win at the DARPA Robotics Challenge (DRC) 2015
Team KAIST, consisted of 29 members (students and researchers) led by Professors Jun-Ho Oh of the Mechanical Engineering Department and In-So Kweon of the Electrical Engineering Department, won the international humanoid robotics competition hosted by the United States (US) Defense Advanced Research Projects Agency (DARPA). Upon completion of the first and second competitions, the finals were held on June 5-6, 2015, at the Fairplex in Pomona, California. DARPA hosted the event to spur the development of humanoid robots to assist rescue and relief efforts in dangerous environments such as the Fukushima Daiichi nuclear incident in 2011. With 24 international teams participating in the finals from the US, Japan, Germany, China, Italy, and Korea, Team KAIST’s humanoid robot, DRC-HUBO, completed all eight tasks in 44 minutes and 28 seconds, six minutes earlier than the runner-up, and almost eleven minutes earlier than the third-place team, walking away with the grand prize of USD 2 million.
Hitting a Grand Slam to Win Major International Design Awards
Professor Sang-Min Bae of the Industrial Design Department achieved a grand slam in international design awards with his work HEARTea, an interactive tumbler, winning four major design competitions in the world: the iF Design Award, the International Design Excellence Awards, the Red Dot Design Award, and the Good Design Award. Released in 2010, HEARTea swept prizes from the four awards which were held during the period of the year 2010-2011. The tumbler displays the temperature of liquid contained inside in three degrees (cool, warm, and hot) by showing different colored lights on the surface of the tumbler based on the liquid temperature (see picture below). In 2015, Professor Bae and his research team won three awards from the 2015 Red Dot Design Award: the Best of the Best Award and two Red Dot Design Concept Awards. The team received the Best of the Best Award, the most prestigious award among the Red Dot Design awards, for Boxchool, a modular classroom built on shipping containers, which offers underprivileged children better opportunities for learning. With greater mobility, Boxchool can be easily installed in any setting, including remote areas where children do not have access to regular school facilities.
Glass Fabric Thermoelectric Generator, the Grand Prize Winner at the Netexplo Forum 2015
Professor Byung-Jin Cho of the Electrical Engineering Department received the grand prize at the Netexplo Forum 2015 held in partnership with the United Nations Educational, Scientific, and Cultural Organization (UNESCO) on February 4-5, 2015, at the UNESCO House in Paris. Established in 2007, the Netexplo Forum is an annual international conference hosted by the Netexplo Observatory, a non-profit organization sponsored by the French Senate and the French Ministry for the Digital Economy, which studies the impact of digital technology on society and business. Each year, the Netexplo Forum highlights major trends in digital technology and innovation worldwide and lists the top ten most promising technologies that it considers will greatly impact the world. Among the list for this year, Professor Cho’s glass fabric-based thermoelectric (TE) generator received the grand prize. Using a screen-printing technique, Professor Cho printed TE liquid materials onto a glass fabric to generate electricity through the thermoelectric effect, that is, by generating electricity from temperature difference. Since the glass fabric is light and flexible, this technology is expected to have a wide range of applications in wearable computers and devices.
Charging on the Go: Online Electric Vehicle System
KAIST’s Online Electric Vehicle (OLEV) is a system that charges electric vehicles while stationary or driving, thus removing the need to stop for charges. Developed by Professor Dong-Ho Cho of the Electrical Engineering Department and his research team, OLEV receives power wirelessly through a new application called “Shaped Magnetic Field in Resonance technology (SMFIR).” Electrical cables buried underneath roads create magnetic fields, and a receiving device installed underneath the electric vehicle collects the fields and converts them into electricity. Time, a US weekly magazine, listed OLEV as one of the 50 Greatest Inventions of the Year 2010 in its November 22nd issue. Since 2012, several OLEV buses have been operating daily to provide citizens with transportation in cities such as Yeosu, Gumi, and Sejong in Korea. In April 2015, Professor Cho signed a memorandum of understanding with the city government of Medellín, the second largest city in Colombia, to provide two OLEV buses for inner-city transportation services. The research team also developed OLEV for a high capacity transit system including trams and high-speed trains, successfully showcasing 60 kHz of power transferred wirelessly to trams and trains in 2013 and 2014, respectively.
Pioneer in the Development of Functional Mesoporous Materials and Zeolites
On September 25, 2014, Thomson Reuters announced the “2014 Citation Laureates,” a list of candidates considered likely to win the Nobel Prize in the fields of physics, chemistry, physiology or medicine, and economics. Distinguished Professor Ryong Ryoo of the Department of Chemistry was named the 2014 Thomson Reuters Citation Laureates in Chemistry in recognition of his significant contribution to the advancement of designing functional mesoporous materials. He is the first Korean scientist to make the list. Professor Ryoo has pioneered the field of functional mesoporous materials and zeolites which are widely used as catalysts and sorbents. In 1999, he developed a nanocasting method, and with the technique, was able to synthesize ordered mesoporous carbon materials, for the first time in the world. Today, ordered mesoporous carbon materials have widespread applications in many areas such as adsorbents, catalysts and supports, gas-storage hosts, and electrode materials. Since 2006, using zeolite frameworks, Professor Ryoo has led the development of new methods to synthesize mesoporous materials whose molecules are designed to have a hierarchical structure of microspores and mesopores. He has published 255 research papers in renowned academic journals including Nature and Science. In December 2011, Science highlighted his research as one of the top ten breakthroughs in the year of 2011 in an article entitled “Directing Zeolite Structures into Hierarchically Nanoporous Architectures.” Professor Ryoo received numerous awards and honors including the World’s Top 100 Chemists over the Past 11 Years (2000-2010) by UNESCO and IUPAC (International Union of Pure and Applied Chemistry), the Breck Award by International Zeolite Association, and the Ho-Am prize in Science.
The Launch of Korea’s First Satellites into Space
Founded in 1989, the Satellite Technology Research Center (SaTReC) at KAIST has led the development of a series of Korean-made satellites over the past 26 years. The first satellite, the Korea Institute of Technology Satellite-1 (KITSAT-1), was launched on August 11, 1992, at the Guiana Space Center in Kourou, French Guiana. KITSAT-1 was designed in collaboration with a British university, the University of Surrey in Guildford. The success of KITSAT-1 sparked nation-wide interest in the development of space technology and led to the subsequent launches of 18 satellites and three carrier rockets such as KITSAT-2 and 3 (meteorological satellites); KSR-1, 2, and 3 (carrier rockets); KOREASAT-1, 2, 3, 5, and 6 (communication satellites); KOMPSAT-1, 2, 3, and 5 (multipurpose satellites); STSAT-1, 2C, and 3 (scientific satellites); and COMS-1 (navigation satellite). The latest scientific satellite, STSAT-3, and an earth observation satellite, KOMPSAT-3A, were launched in 2013 and 2015, respectively. The STSAT-2C, exclusively developed by SaTReC, was launched in January 2013 and transmitted data on the observation of space environments to the ground station located on KAIST’s campus for 14 months. The STSAT-2C was the first satellite developed solely with Korean technology. On June 30, 2009, the Korean government also established a spaceport in South Jeolla’s Goheung County, the Naro Space Center to launch satellites and spacecraft.
KAIST: Major Feeder for Startups in Korea
As seen in its core values of promoting creativity and a challenging spirit, KAIST has always encouraged startups and technology transfers led by university members including students and faculty. In the past four years from 2011 to 2014, students and faculty members have created 104 startups based on technology innovation and research outcomes, with an average of 26 new companies started per year. This is the highest number of university-led startups in Korea. As of 2013, KAIST graduates founded a total of 1,245 companies, generating approximately USD 1.5 billion sales and creating 34,000 jobs. KAIST has provided a variety of programs and facilities to build a startup-friendly campus culture and support student- and faculty-led entrepreneurship, for example, the End-Run Policy, Startup KAIST Studio, the Institute of Startup and Entrepreneurship, and the Startup Incubation Center. In particular, KAIST Idea Factory, a startup laboratory established last year, where students play around with ideas by conducting new experiments or building test products, created 3-D printers this year, producing 20 prototypes and filing four pending patents. Recently, KAIST has registered four proprietary standard patents with MPEG (Moving Picture Experts Group)-LA’s HEVC (High Efficiency Video Coding) Patent Portfolio License, which provides access to essential patent rights for the HEVC digital video coding standard. KAIST expects to acquire more than 50 proprietary standard patents within two years, generating close to UDS 1 million in income.
The Number of KAIST Doctoral Graduates Reaches Over 10,000
Since the establishment of KAIST forty-four years ago, more than ten thousand alumni have received their doctorates. The university’s 2015 Commencement ceremony took place on February 13, 2015, at the Sports Complex on campus, awarding Dr. Sun-Mi Cho of the Department of Biological Sciences the 10,000th doctoral degree. She also received her Bachelor’s and Master’s degrees from KAIST. In 1978, KAIST had only two doctoral graduates, but since 1987, there have been more than one hundred graduates each year, two hundred since 1994, and four hundred since 2000. In 2015 alone, 522 doctoral students graduated. One of the first doctoral graduates, Dr. Dong-Yol Yang (Class of 1978 in the Mechanical Engineering Department) became a professor in the same department of KAIST. In the early 1970s, many Koreans preferred to go abroad for Ph.D. degrees, but this changed when KAIST began to select candidates for master’s degrees in 1973, and doctoral degrees in 1975. Talented Korean students began to work in KAIST laboratories, and its graduates were known for their knowledge and skills. Now, KAIST receives many applications from talented foreign students as well. At the 2015 Commencement, KAIST conferred 522 Doctoral, 1,241 Master’s, and 915 Bachelor of Science degrees. Since its inception in 1971, KAIST has granted 10,403 doctoral degrees, 26,402 master’s degrees, and 51,412 bachelor’s degrees.
Fostering a New Learning Model: The Education 3.0 Program
KAIST undertook a bold initiative to improve its education system that would address more effectively the needs of today’s higher education to foster talents with creative and critical thinking skills. It introduced a new pedagogical model, the Education 3.0 program, to the campus in the spring of 2012, which was then an extremely rare movement taken by universities around the world. The Education 3.0 program incorporates flipped learning and smart classrooms. This means there are no formal lectures while in-class time is devoted to problem solving, exercises, projects, or discussions. The program provided students with greater opportunity to control their learning and interact more with professors and peers. Originally started with three general courses in physics, chemistry, and biology, the Education 3.0 is now offered in 50-60 courses per semester. In 2013 alone, approximately 2,000 KAIST students took the Education 3.0 courses. The university has also developed and implemented an e-Learning system to provide online courses, as well as participated in the Massive Open Online Course (MOOC). Partnering with Coursera since 2013, KAIST has offered three MOOCs in engineering and business management to the global community. Leading the efforts to create Korean MOOCs (K-MOOCs), KAIST agreed with other Korean universities in October 2015 to create online courses in basic subjects of physics, chemistry, mathematics, life science, mechanical engineering, and material science. K-MOOCs will be available in the summer of 2016.
Holistic Admissions for Undergraduates
Korean universities traditionally put an emphasis on students’ empirical data such as a GPA or the national College Scholastic Ability Test (CSAT) when reviewing applicants for the undergraduate admission. This practice, however, has posed serious challenges, most notably with CSAT’s requirement that the test takes place only once a year. It was simply impossible and unfair to assess students’ capability from the scores of a high-pressure, high-stakes standardized test. In 2009, KAIST changed its undergraduate admission process to consider the whole applicant’s profile, not just looking for students with good grades, but interesting and promising students who would contribute to the campus community in different and diverse ways. KAIST’s admissions officers have taken into account applicants’ interests, passions, special talents, and personality through their personal essays, recommendation letters, extracurricular activities, and intensive interviews. Prior to KAIST’s new policy, no other university in the nation had ever incorporated such a holistic approach to review student applications. Today, most Korean universities have adopted this admission policy. In addition, for the first time in Korea, KAIST offered all freshmen the option to defer the decision on majors, thereby allowing them to explore their interests more freely. Even after declaring majors as sophomores and higher classes, KAIST students can easily change their majors, and undergraduate students can actually create and lead their own research projects. As such, KAIST has continued to offer innovations to provide students with a quality education to foster their potential.
2015.11.27 View 16463 -
Dr. Ryu of KAIST Receives the S-Oil Outstanding Paper Award
Dr. Je-Kyung Ryu of KAIST’s Department of Physics has been awarded the S-Oil Outstanding Paper Award for his doctoral dissertation’s originality and applicability.
Professor Tae-Young Yoon of Physics is his doctoral advisor.
The award ceremony took place on November 25, 2015 at the Press Center in Seoul.
This S-Oil Outstanding Paper Award, jointly sponsored by the Korean Academy of Science and Technology (KAST) and the Scholastic University Presidential Association, was established to foster young talented scientists in basic science and to advance the field.
The award is given every other year for each of the fields of physics, chemistry, mathematics, biology, and earth sciences.
With the award, Dr. Ryu received a research grant of USD 8,600.
He discovered, for the first time in the world, how NSF (N-ethylmaleimide-sensitive factor), a protein involved in a vesicular transport in cellular activities, disassembles a SNARE (soluble NSF attachment protein receptor) complex, using a unimolecular biophysics method.
Unlike the existing studies, he proposed a model in which NSF disassembles SNARE complexes at one step, and as a result, provided evidence of how the SNARE complex influenced the fusion of biological membranes.
His research was published in the scientific journal Science issued on March 27, 2015. The title of the paper is “Spring-loaded Unraveling of a Single SNARE Complex by NSF in One Round of ATP Turnover.”
2015.11.27 View 7962 -
HUBO to Present at the 2016 World Economic Forum
KAIST researchers will lead an IdeasLab on biotechnology for an aging society while HUBO, the winner of the 2015 DARPA Robotics Challenge, will interact with the forum participants, offering an experience of state-of-the-art robotics technology.
Representatives from KAIST will attend the 2016 Annual Meeting of the World Economic Forum to run an IdeasLab and showcase its humanoid robot.
With over 2,500 leaders from business, government, international organizations, civil society, academia, media, and the arts expected to participate, the 2016 Annual Meeting will take place on January 20-23, 2016 in Davos-Klosters, Switzerland. Under the theme of “Mastering the Fourth Industrial Revolution,” global leaders will discuss the period of digital transformation that will have profound effects on economies, societies, and human behavior.
President Sung-Mo Kang will join the Global University Leaders Forum (GULF), a high-level academic meeting to foster collaboration among experts on issues of global concern for the future of higher education and the role of science in society. He will discuss how the emerging revolution in technology will affect the way universities operate and serve society. KAIST is the only Korean university participating in GULF, which is composed of prestigious universities invited from around the world.
Four KAIST professors, including Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department, will lead an IdeasLab on “Biotechnology for an Aging Society.”
Professor Lee said, “In recent decades, much attention has been paid to the potential effect of the growth of an aging population and problems posed by it. At our IdeasLab, we will introduce some of our research breakthroughs in biotechnology to address the challenges of an aging society.”
In particular, he will present his latest research in systems biotechnology and metabolic engineering. His research has explained the mechanisms of how traditional Oriental medicine works in our bodies by identifying structural similarities between effective compounds in traditional medicine and human metabolites, and has proposed more effective treatments by employing such compounds.
KAIST will also display its networked mobile medical service system, “Dr. M.” Built upon a ubiquitous and mobile Internet, such as the Internet of Things, wearable electronics, and smart homes and vehicles, Dr. M will provide patients with a more affordable and accessible healthcare service.
In addition, Professor Jun-Ho Oh of the Mechanical Engineering Department will showcase his humanoid robot, “HUBO,” during the Annual Meeting. His research team won the International Humanoid Robotics Challenge hosted by the United States Defense Advanced Research Projects Agency (DARPA), which was held in Pomona, California, on June 5-6, 2015. With 24 international teams participating in the finals, HUBO completed all eight tasks in 44 minutes and 28 seconds, 6 minutes earlier than the runner-up, and almost 11 minutes earlier than the third-place team. Team KAIST walked away with the grand prize of USD 2 million.
Professor Oh said, “Robotics technology will grow exponentially in this century, becoming a real driving force to expedite the Fourth Industrial Revolution. I hope HUBO will offer an opportunity to learn about the current advances in robotics technology.”
President Kang pointed out, “KAIST has participated in the Annual Meeting of the World Economic Forum since 2011 and has engaged with a broad spectrum of global leaders through numerous presentations and demonstrations of our excellence in education and research. Next year, we will choreograph our first robotics exhibition on HUBO and present high-tech research results in biotechnology, which, I believe, epitomizes how science and technology breakthroughs in the Fourth Industrial Revolution will shape our future in an unprecedented way.”
2015.11.18 View 11341 -
Open KAIST 2015
KAIST’s research environment and its most recent achievements were open to the public.
KAIST hosted “Open KAIST 2015” over two days from November 5-6, 2015 in which its 17 departments and three research centers were open to the public. The event is one of the largest events that KAIST holds, which permits such public viewings of its facilities. It is the eighth time it has taken place.
During this event, the departments and centers offered 64 programs including laboratory tours, research achievement exhibitions, department introductions, and special lectures.
The “Motion Capture System”of Professor Jun-Yong Noh’s lab (Graduate School of Culture Technology) drew particular attention.
The “Motion Capture System” expresses human and animal motion in three-dimensional (3D) space using infrared cameras and optic markers, which can then be applied to various industries such as movies, games, and animation. During the program, researchers themselves demonstrated the recording of the movement and its conversion into 3D characters.
Professor Yong-Hoon Cho’s laboratory introduced the scientific mechanism behind the Light Emitting Diode (LED) as well as its manufacturing process under the topic:“A to Z of LED Production.” The reserachers explained that how green LED is much more efficient compared to previous light sources and presented applications that how it is widely used in everyday life in smart phones, electronic displays, and other mobile gadgets.
Professor Jun-tani of the Department of Electronic and Electrical Engineering introduced “Humanoid Robot Nao’s Imitation of Human Motions.” Nao is an autonomous, programmable humanoid robot developed by a French robotics company based in Paris. Nao has an artificial neural circuit, which is the functional equivalent of a human brain, and can thus mimic the subject’s motions through learning.
In addition, Professor Hyo-Choong Bang (Department of Aerospace Engineering) in his lecture on “Unmanned Vehicle Research and Nano Satellites” and Professor Hyun Myung (Department of Civil and Environmental Engineering) on his lecture on “Future Civilization Robot System: the Jellyfish Elimination Robotic Swarm and the Wall-Climbing Drone” provided information on the progress of their respective research.
KAIST also displayed its most recent research achievements. A lecture on “Information Technology Convergence” offered a showroom for “Dr. M,” which is a mobile healthcare platform. Dr. M is a mobile healthcare system that collects and analyzes biosignals via a smart sensor attached to the human body that shows around 20 advanced technologies.
The Satellite Technology Research Center introduced the public to its “Get to Know Satellites” program on Korea’s first satellite “Our Star 1” in addition to showing the satellite assembly room and the satellite communication center.
Special lectures were also held for visitors. Professor Min-Hyuk Kim and Hye-Yeon Oh of the School of Computing talked about “Computer Graphics and Advanced Video Technology” and “Man and the Computer,” respectively, from the perspective of non-experts.
Another interesting feature was the “Wearable Computer Competition” in which college students held fashion shows with computers attached to their clothes.
Professor Jung Kwon Lee, the Dean of the College of Engineering, who led this event, said that “the Open KAIST, which is being held for the eighth time this year, is an excellent opportunity for the general public to experience KAIST’s research environment.” He hoped this could motivate young adults to widen their spectrum of scientific knowledge and raise affection for science.
2015.11.13 View 9543 -
Mapping the Folding Process of a Single Membrane Protein
KAIST and UCLA scientists were able to observe an individual membrane protein fold and unfold by pulling and releasing magnetically trapped protein molecules.
Proteins are huge molecules containing hundreds to thousands of atoms that adopt a unique three dimensional structure, placing chemical groups in just the right place to catalyze reactions or build cellular structures. How all those atoms manage to find the right location - the so-called folding problem - has fascinated molecular biologists since the first structures were seen in the 1950s. Moreover, folding has important medical implications because most genetic defects cause protein misfolding.
About a third of all proteins float around in the cell membrane where they ensure the right chemicals get in the cell in the right amounts. Membrane proteins also provide key information links between the cell and its environment. Indeed, most drugs target membrane proteins. Nevertheless, the folding of membrane proteins has been particularly difficult to study and has rarely been studied in natural environments, leaving the folding process for a large fraction of the protein universe still largely cloaked in mystery.
In a recent issue of Nature Chemical Biology, published on October 19, 2015, a research team led by Tae-Young Yoon of the Department of Physics at the Korea Advanced Institute of Science and Technology (KAIST) and James U. Bowie of the Department of Chemistry and Biochemistry at the University of California, Los Angeles (UCLA), report a new method for manipulating the folding of membrane proteins in a membrane environment using a tool called a magnetic tweezer.
Researchers first attach long DNA handles to the ends of the protein. One handle is attached to a glass surface and the other to a magnetic bead. Using a magnet, they can essentially grab the protein and pull on it, inducing it to unfold. By playing with the bead attached to the protein, they can force the protein to unfold or allow it to refold, and watch all this happening by 3D-tracking of the magnetic bead. With this novel strategy, they were able to quantitatively map the folding energy landscape, the folding kinetic rate, and folding intermediates of a membrane protein in a membrane environment for the first time.
“I have been dreaming about this experiment for a decade. To see it work so well is really gratifying,” said Dr. Bowie.
One of the major surprises in the study was that essentially all the atoms of the protein jump into the correct structure together. The researchers expected that the protein structure would come together in a more piecemeal fashion, with different parts of the structure forming separately, but that was not the case. It is possible that nature evolved such a smooth, highly cooperative folding process to prevent partially folded forms that could get into trouble in the crowded cell membrane. On the other hand, the cooperative folding seen here might not apply to other membrane proteins.
“We need to look at more proteins. The technique developed here may allow us to do just that,” said Dr. Yoon.
The single molecule mechanical manipulation technique could enable detailed folding studies of many other membrane proteins. A major barrier to the study of membrane proteins previously is that the proteins tend to stick together and get tangled up, as computer cords lying at your feet tend to do. With the tweezer technique used in this work, the protein cords are held apart from other cords so they can’t get knotted up. It is hoped that the new approach will open up an important part of the protein universe to scrutiny, including many proteins that become misfolded in disease states.
The title of the research paper is “Mapping the energy landscape for second-stage folding of a single membrane protein” (DOI: 10.1038/nchembio.1939).
Picture: Single-molecule magnetic tweezers that induce mechanical unfolding and refolding of a single membrane protein. Since the force applied is parallel to the biological lipid membrane, the unfolding and refolding processes occur within the membrane.
2015.10.20 View 9331