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Singularity Professors Represent the Future of Research at KAIST
KAIST will launch a Singularity Professor track, which gives more freedom to researchers for pursuing their research goal. This more flexible and creative research environment institutionally supports researchers as they dive deeper into their research for a longer period of time without any strings attached.
The track was established in an effort to ensure more competitive researchers who can lead the way for new advances in science and technology. This innovative research initiative is part of KAIST’s expansive effort to envision and position itself to build global research competitiveness in the wake of its 50th anniversary in 2021 and beyond.
From this year, KAIST will select two to three research faculty for this special track with full-scale funding for 10 years. Singularity Professors will have their annual performance evaluations waived for 10 years. Instead, their research will be reviewed in their fifth year. The professors in this track will not participate in government-funded R&D projects and be fully funded by KAIST’s endowment.
In addition to those newly hired into this track, Singularity Professorships are opens to existing faculty members. The selection criteria are very simple but highly demanding: one who can pivot an existing academic paradigm or invent a new discipline by presenting a novel scientific theory.
KAIST recently hosted a briefing session for current faculty members and encouraged them to apply for the new track. As part of the selection criteria, the research topic’s innovativeness, feasibility, and appropriateness will be major factors for this track. Employment under this track will continue for up to 20 years. After receiving an evaluation of Very Satisfactory at the end of first ten-year contract, another ten years will be added.
President Sung-Chul Shin, who has pushed for this system since he took office in 2017, said during the briefing session, “It takes quite a long time to bear fruit in academics, especially in science. I am very delighted that KAIST is paving the way for building a longer-term research environment which allows full and longer commitments for research that the faculty is excited to try. That’s the first step to sow the seeds for bearing fruit in academics, especially in science.”
This is a paradigm shift to embrace transformation in a new era. The new institutional strategy supports the change from a fast follower to a first mover during these technologically turbulent times. Under its Global Singularity Research Projects initiative, KAIST already selected focus research topics in the most challenging as well as most creative fields of neuro-rehabilitation, new materials, and molecular optogenetics.
“Especially in the post-COVID era, we have a very clear mission for the world. Our knowledge should translate into global value that can benefit those suffering from this pandemic, and mitigate the inequity coming from the digital discrepancies,” President Shin added.
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2020.07.21 View 7414 -
Every Moment of Ultrafast Chemical Bonding Now Captured on Film
- The emerging moment of bond formation, two separate bonding steps, and subsequent vibrational motions were visualized. -
< Emergence of molecular vibrations and the evolution to covalent bonds observed in the research. Video Credit: KEK IMSS >
A team of South Korean researchers led by Professor Hyotcherl Ihee from the Department of Chemistry at KAIST reported the direct observation of the birthing moment of chemical bonds by tracking real-time atomic positions in the molecule. Professor Ihee, who also serves as Associate Director of the Center for Nanomaterials and Chemical Reactions at the Institute for Basic Science (IBS), conducted this study in collaboration with scientists at the Institute of Materials Structure Science of High Energy Accelerator Research Organization (KEK IMSS, Japan), RIKEN (Japan), and Pohang Accelerator Laboratory (PAL, South Korea). This work was published in Nature on June 24.
Targeted cancer drugs work by striking a tight bond between cancer cell and specific molecular targets that are involved in the growth and spread of cancer. Detailed images of such chemical bonding sites or pathways can provide key information necessary for maximizing the efficacy of oncogene treatments. However, atomic movements in a molecule have never been captured in the middle of the action, not even for an extremely simple molecule such as a triatomic molecule, made of only three atoms.
Professor Ihee's group and their international collaborators finally succeeded in capturing the ongoing reaction process of the chemical bond formation in the gold trimer. "The femtosecond-resolution images revealed that such molecular events took place in two separate stages, not simultaneously as previously assumed," says Professor Ihee, the corresponding author of the study. "The atoms in the gold trimer complex atoms remain in motion even after the chemical bonding is complete. The distance between the atoms increased and decreased periodically, exhibiting the molecular vibration. These visualized molecular vibrations allowed us to name the characteristic motion of each observed vibrational mode." adds Professor Ihee.
Atoms move extremely fast at a scale of femtosecond (fs) ― quadrillionths (or millionths of a billionth) of a second. Its movement is minute in the level of angstrom equal to one ten-billionth of a meter. They are especially elusive during the transition state where reaction intermediates are transitioning from reactants to products in a flash. The KAIST-IBS research team made this experimentally challenging task possible by using femtosecond x-ray liquidography (solution scattering). This experimental technique combines laser photolysis and x-ray scattering techniques. When a laser pulse strikes the sample, X-rays scatter and initiate the chemical bond formation reaction in the gold trimer complex. Femtosecond x-ray pulses obtained from a special light source called an x-ray free-electron laser (XFEL) were used to interrogate the bond-forming process. The experiments were performed at two XFEL facilities (4th generation linear accelerator) that are PAL-XFEL in South Korea and SACLA in Japan, and this study was conducted in collaboration with researchers from KEK IMSS, PAL, RIKEN, and the Japan Synchrotron Radiation Research Institute (JASRI).
Scattered waves from each atom interfere with each other and thus their x-ray scattering images are characterized by specific travel directions. The KAIST-IBS research team traced real-time positions of the three gold atoms over time by analyzing x-ray scattering images, which are determined by a three-dimensional structure of a molecule. Structural changes in the molecule complex resulted in multiple characteristic scattering images over time. When a molecule is excited by a laser pulse, multiple vibrational quantum states are simultaneously excited. The superposition of several excited vibrational quantum states is called a wave packet. The researchers tracked the wave packet in three-dimensional nuclear coordinates and found that the first half round of chemical bonding was formed within 35 fs after photoexcitation. The second half of the reaction followed within 360 fs to complete the entire reaction dynamics.
They also accurately illustrated molecular vibration motions in both temporal- and spatial-wise. This is quite a remarkable feat considering that such an ultrafast speed and a minute length of motion are quite challenging conditions for acquiring precise experimental data.
In this study, the KAIST-IBS research team improved upon their 2015 study published by Nature. In the previous study in 2015, the speed of the x-ray camera (time resolution) was limited to 500 fs, and the molecular structure had already changed to be linear with two chemical bonds within 500 fs. In this study, the progress of the bond formation and bent-to-linear structural transformation could be observed in real time, thanks to the improvement time resolution down to 100 fs. Thereby, the asynchronous bond formation mechanism in which two chemical bonds are formed in 35 fs and 360 fs, respectively, and the bent-to-linear transformation completed in 335 fs were visualized. In short, in addition to observing the beginning and end of chemical reactions, they reported every moment of the intermediate, ongoing rearrangement of nuclear configurations with dramatically improved experimental and analytical methods.
They will push this method of 'real-time tracking of atomic positions in a molecule and molecular vibration using femtosecond x-ray scattering' to reveal the mechanisms of organic and inorganic catalytic reactions and reactions involving proteins in the human body. "By directly tracking the molecular vibrations and real-time positions of all atoms in a molecule in the middle of reaction, we will be able to uncover mechanisms of various unknown organic and inorganic catalytic reactions and biochemical reactions," notes Dr. Jong Goo Kim, the lead author of the study.
Publications:
Kim, J. G., et al. (2020) ‘Mapping the emergence of molecular vibrations mediating bond formation’. Nature. Volume 582. Page 520-524. Available online at https://doi.org/10.1038/s41586-020-2417-3
Profile: Hyotcherl Ihee, Ph.D.
Professor
hyotcherl.ihee@kaist.ac.kr
http://time.kaist.ac.kr/
Ihee Laboratory
Department of Chemistry
KAIST
https://www.kaist.ac.kr
Daejeon 34141, Korea
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2020.06.24 View 14812 -
Energy Storage Using Oxygen to Boost Battery Performance
Researchers have presented a novel electrode material for advanced energy storage device that is directly charged with oxygen from the air. Professor Jeung Ku Kang’s team synthesized and preserved the sub-nanometric particles of atomic cluster sizes at high mass loadings within metal-organic frameworks (MOF) by controlling the behavior of reactants at the molecular level. This new strategy ensures high performance for lithium-oxygen batteries, acclaimed as a next-generation energy storage technology and widely used in electric vehicles.
Lithium-oxygen batteries in principle can generate ten times higher energy densities than conventional lithium-ion batteries, but they suffer from very poor cyclability. One of the methods to improve cycle stability is to reduce the overpotential of electrocatalysts in cathode electrodes. When the size of an electrocatalyst material is reduced to the atomic level, the increased surface energy leads to increased activity while significantly accelerating the material’s agglomeration.
As a solution to this challenge, Professor Kang from the Department of Materials Science and Engineering aimed to maintain the improved activity by stabilizing atomic-scale sized electrocatalysts into the sub-nanometric spaces. This is a novel strategy for simultaneously producing and stabilizing atomic-level electrocatalysts within metal-organic frameworks (MOFs).
Metal-organic frameworks continuously assemble metal ions and organic linkers.
The team controlled hydrogen affinities between water molecules to separate them and transfer the isolated water molecules one by one through the sub-nanometric pores of MOFs. The transferred water molecules reacted with cobalt ions to form di-nuclear cobalt hydroxide under precisely controlled synthetic conditions, then the atomic-level cobalt hydroxide is stabilized inside the sub-nanometric pores.
The di-nuclear cobalt hydroxide that is stabilized in the sub-nanometric pores of metal-organic frameworks (MOFs) reduced the overpotential by 63.9% and showed ten-fold improvements in the life cycle.
Professor Kang said, “Simultaneously generating and stabilizing atomic-level electrocatalysts within MOFs can diversify materials according to numerous combinations of metal and organic linkers. It can expand not only the development of electrocatalysts, but also various research fields such as photocatalysts, medicine, the environment, and petrochemicals.”
This study was reported in Advanced Science (Title: Autogenous Production and Stabilization of Highly Loaded Sub-Nanometric Particles within Multishell Hollow Metal-Organic Frameworks and Their Utilization for High Performance in Li-O2 Batteries).
This research was mainly supported by the Global Frontier R&D Program of the Ministry of Science, ICT & Planning (Grant No. 2013M3A6B1078884) funded by the Ministry of Science, ICT & Future Planning, and the National Research Foundation of Korea (Grant No. 2019M3E6A1104196).
Profile:Professor Jeung Ku Kang
jeungku@kaist.ac.kr
http://nanosf.kaist.ac.kr/
Nano Materials Simulation and Fabrication Laboratory
Department of Materials Science and Engineering
KAIST
2020.06.15 View 11153 -
A Deep-Learned E-Skin Decodes Complex Human Motion
A deep-learning powered single-strained electronic skin sensor can capture human motion from a distance. The single strain sensor placed on the wrist decodes complex five-finger motions in real time with a virtual 3D hand that mirrors the original motions. The deep neural network boosted by rapid situation learning (RSL) ensures stable operation regardless of its position on the surface of the skin.
Conventional approaches require many sensor networks that cover the entire curvilinear surfaces of the target area. Unlike conventional wafer-based fabrication, this laser fabrication provides a new sensing paradigm for motion tracking.
The research team, led by Professor Sungho Jo from the School of Computing, collaborated with Professor Seunghwan Ko from Seoul National University to design this new measuring system that extracts signals corresponding to multiple finger motions by generating cracks in metal nanoparticle films using laser technology. The sensor patch was then attached to a user’s wrist to detect the movement of the fingers.
The concept of this research started from the idea that pinpointing a single area would be more efficient for identifying movements than affixing sensors to every joint and muscle. To make this targeting strategy work, it needs to accurately capture the signals from different areas at the point where they all converge, and then decoupling the information entangled in the converged signals. To maximize users’ usability and mobility, the research team used a single-channeled sensor to generate the signals corresponding to complex hand motions.
The rapid situation learning (RSL) system collects data from arbitrary parts on the wrist and automatically trains the model in a real-time demonstration with a virtual 3D hand that mirrors the original motions. To enhance the sensitivity of the sensor, researchers used laser-induced nanoscale cracking.
This sensory system can track the motion of the entire body with a small sensory network and facilitate the indirect remote measurement of human motions, which is applicable for wearable VR/AR systems.
The research team said they focused on two tasks while developing the sensor. First, they analyzed the sensor signal patterns into a latent space encapsulating temporal sensor behavior and then they mapped the latent vectors to finger motion metric spaces.
Professor Jo said, “Our system is expandable to other body parts. We already confirmed that the sensor is also capable of extracting gait motions from a pelvis. This technology is expected to provide a turning point in health-monitoring, motion tracking, and soft robotics.”
This study was featured in Nature Communications.
Publication:
Kim, K. K., et al. (2020) A deep-learned skin sensor decoding the epicentral human motions. Nature Communications. 11. 2149. https://doi.org/10.1038/s41467-020-16040-y29
Link to download the full-text paper:
https://www.nature.com/articles/s41467-020-16040-y.pdf
Profile: Professor Sungho Jo
shjo@kaist.ac.kr
http://nmail.kaist.ac.kr
Neuro-Machine Augmented Intelligence Lab
School of Computing
College of Engineering
KAIST
2020.06.10 View 10789 -
Professor Jee-Hwan Ryu Receives IEEE ICRA 2020 Outstanding Reviewer Award
Professor Jee-Hwan Ryu from the Department of Civil and Environmental Engineering was selected as this year’s winner of the Outstanding Reviewer Award presented by the Institute of Electrical and Electronics Engineers International Conference on Robotics and Automation (IEEE ICRA). The award ceremony took place on June 5 during the conference that is being held online May 31 through August 31 for three months.
The IEEE ICRA Outstanding Reviewer Award is given every year to the top reviewers who have provided constructive and high-quality thesis reviews, and contributed to improving the quality of papers published as results of the conference.
Professor Ryu was one of the four winners of this year’s award. He was selected from 9,425 candidates, which was approximately three times bigger than the candidate pool in previous years. He was strongly recommended by the editorial committee of the conference.
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2020.06.10 View 7371 -
A New Strategy for the Optimal Electroreduction of CO2 to High-Value Products
-Researchers suggest that modulation of local CO2 concentration improves the selectivity, conversion rate, and electrode stability, and shed a new light on the electrochemical CO2 reduction technology for controlling emissions at a low cost.-
A KAIST research team presented three novel approaches for modulating local carbon dioxide (CO2) concentration in gas-diffusion electrode (GDE)-based flow electrolyzers. Their study also empirically demonstrated that providing a moderate local CO2 concentration is effective in promoting Carbon–Carbon (C–C) coupling reactions toward the production of multi-carbon molecules. This work, featured in the May 20th issue of Joule, serves as a rational guide to tune CO2 mass transport for the optimal production of valuable multi-carbon products.
Amid global efforts to reduce and recycle anthropogenic CO2 emissions, CO2 electrolysis holds great promise for converting CO2 into useful chemicals that were traditionally derived from fossil fuels. Many researches have been attempting to improve the selectivity of CO2 for commercially and industrially high-value multi-carbon products such as ethylene, ethanol, and 1-propanol, due to their high energy density and large market size.
In order to achieve the highly-selective conversion of CO2 into valuable multi-carbon products, past studies have focused on the design of catalysts and the tuning of local environment related to pH, cations, and molecular additives.
Conventional CO2 electrolytic systems relied heavily on an alkaline electrolyte that is often consumed in large quantities when reacting with CO2, and thus led to an increase in the operational costs. Moreover, the life span of a catalyst electrode was short, due to its inherent chemical reactivity.
In their recent study, a group of KAIST researchers led by Professor Jihun Oh from the Department of Materials Science and Engineering reported that the local CO2 concentration has been an overlooked factor that largely affects the selectivity toward multi-carbon products.
Professor Oh and his researchers Dr. Ying Chuan Tan, Hakhyeon Song, and Kelvin Berm Lee proposed that there is an intimate relation between local CO2 and multi-carbon product selectivity during electrochemical CO2 reduction reactions. The team employed the mass-transport modeling of a GDE-based flow electrolyzer that utilizes copper oxide (Cu2O) nanoparticles as model catalysts. They then identified and applied three approaches to modulate the local CO2 concentration within a GDE-based electrolytic system, including 1) controlling the catalyst layer structure, 2) CO2 feed concentration, and 3) feed flow rate.
Contrary to common intuition, the study showed that providing a maximum CO2 transport leads to suboptimal multi-carbon product faradaic efficiency. Instead, by restricting and providing a moderate local CO2 concentration, C–C coupling can be significantly enhanced.
The researchers demonstrated experimentally that the selectivity rate increased from 25.4% to 61.9%, and from 5.9% to 22.6% for the CO2 conversion rate. When a cheap milder near-neutral electrolyte was used, the stability of the CO2 electrolytic system improved to a great extent, allowing over 10 hours of steady selective production of multi-carbon products.
Dr. Tan, the lead author of the paper, said, “Our research clearly revealed that the optimization of the local CO2 concentration is the key to maximizing the efficiency of converting CO2 into high-value multi-carbon products.”
Professor Oh added, “This finding is expected to deliver new insights to the research community that variables affecting local CO2 concentration are also influential factors in the electrochemical CO2 reduction reaction performance. My colleagues and I hope that our study becomes a cornerstone for related technologies and their industrial applications.”
This work was supported by the Korean Ministry of Science and ICT (MSIT) Creative Materials Discovery Program.
Publication:
Tan, Y. C et al. (2020) ‘Modulating Local CO2 Concentration as a General Strategy for Enhancing C−C Coupling in CO2 Electroreduction’, Joule, Vol. 4, Issue 5, pp. 1104-1120. Available online at https://doi.org/10.1016/j.joule.2020.03.013
Profile: Jihun Oh, PhD
Associate Professor
jihun.oh@kaist.ac.kr
http://les.kaist.ac.kr/
Laboratory for Energy and Sustainability (LE&S)
Department of Materials Science and Engineering (MSE)
Korea Advanced Institute of Science and Technology (KAIST)
https://www.kaist.ac.kr
Daejeon 34141, Republic of Korea
Profile: Ying Chuan Tan, PhD
tanyc@kaist.ac.kr
LE&S, MSE, KAIST
Profile: Hakhyeon Song, PhD Candidate
hyeon0401@kaist.ac.kr
LE&S, MSE, KAIST
Profile: Kelvin Berm Lee, M.S. Candidate
kbl9105@kaist.ac.kr
LE&S, MSE, KAIST
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2020.06.03 View 10688 -
Universal Virus Detection Platform to Expedite Viral Diagnosis
Reactive polymer-based tester pre-screens dsRNAs of a wide range of viruses without their genome sequences
The prompt, precise, and massive detection of a virus is the key to combat infectious diseases such as Covid-19. A new viral diagnostic strategy using reactive polymer-grafted, double-stranded RNAs will serve as a pre-screening tester for a wide range of viruses with enhanced sensitivity.
Currently, the most widely using viral detection methodology is polymerase chain reaction (PCR) diagnosis, which amplifies and detects a piece of the viral genome. Prior knowledge of the relevant primer nucleic acids of the virus is quintessential for this test.
The detection platform developed by KAIST researchers identifies viral activities without amplifying specific nucleic acid targets. The research team, co-led by Professor Sheng Li and Professor Yoosik Kim from the Department of Chemical and Biomolecular Engineering, constructed a universal virus detection platform by utilizing the distinct features of the PPFPA-grafted surface and double-stranded RNAs.
The key principle of this platform is utilizing the distinct feature of reactive polymer-grafted surfaces, which serve as a versatile platform for the immobilization of functional molecules. These activated surfaces can be used in a wide range of applications including separation, delivery, and detection. As long double-stranded RNAs are common byproducts of viral transcription and replication, these PPFPA-grafted surfaces can detect the presence of different kinds of viruses without prior knowledge of their genomic sequences.
“We employed the PPFPA-grafted silicon surface to develop a universal virus detection platform by immobilizing antibodies that recognize double-stranded RNAs,” said Professor Kim.
To increase detection sensitivity, the research team devised two-step detection process analogues to sandwich enzyme-linked immunosorbent assay where the bound double-stranded RNAs are then visualized using fluorophore-tagged antibodies that also recognize the RNAs’ double-stranded secondary structure.
By utilizing the developed platform, long double-stranded RNAs can be detected and visualized from an RNA mixture as well as from total cell lysates, which contain a mixture of various abundant contaminants such as DNAs and proteins.
The research team successfully detected elevated levels of hepatitis C and A viruses with this tool.
“This new technology allows us to take on virus detection from a new perspective. By targeting a common biomarker, viral double-stranded RNAs, we can develop a pre-screening platform that can quickly differentiate infected populations from non-infected ones,” said Professor Li.
“This detection platform provides new perspectives for diagnosing infectious diseases. This will provide fast and accurate diagnoses for an infected population and prevent the influx of massive outbreaks,” said Professor Kim.
This work is featured in Biomacromolecules. This work was supported by the Agency for Defense Development (Grant UD170039ID), the Ministry of Science and ICT (NRF-2017R1D1A1B03034660, NRF-2019R1C1C1006672), and the KAIST Future Systems Healthcare Project from the Ministry of Science and ICT (KAISTHEALTHCARE42).
Profile:-Professor Yoosik KimDepartment of Chemical and Biomolecular Engineeringhttps://qcbio.kaist.ac.kr
KAIST-Professor Sheng LiDepartment of Chemical and Biomolecular Engineeringhttps://bcpolymer.kaist.ac.kr
KAIST
Publication:Ku et al., 2020. Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity. Biomacromolecules (https://doi.org/10.1021/acs.biomac.0c00379).
2020.06.01 View 17100 -
Visualization of Functional Components to Characterize Optimal Composite Electrodes
Researchers have developed a visualization method that will determine the distribution of components in battery electrodes using atomic force microscopy. The method provides insights into the optimal conditions of composite electrodes and takes us one step closer to being able to manufacture next-generation all-solid-state batteries.
Lithium-ion batteries are widely used in smart devices and vehicles. However, their flammability makes them a safety concern, arising from potential leakage of liquid electrolytes.
All-solid-state lithium ion batteries have emerged as an alternative because of their better safety and wider electrochemical stability. Despite their advantages, all-solid-state lithium ion batteries still have drawbacks such as limited ion conductivity, insufficient contact areas, and high interfacial resistance between the electrode and solid electrolyte.
To solve these issues, studies have been conducted on composite electrodes in which lithium ion conducting additives are dispersed as a medium to provide ion conductive paths at the interface and increase the overall ionic conductivity.
It is very important to identify the shape and distribution of the components used in active materials, ion conductors, binders, and conductive additives on a microscopic scale for significantly improving the battery operation performance.
The developed method is able to distinguish regions of each component based on detected signal sensitivity, by using various modes of atomic force microscopy on a multiscale basis, including electrochemical strain microscopy and lateral force microscopy.
For this research project, both conventional electrodes and composite electrodes were tested, and the results were compared. Individual regions were distinguished and nanoscale correlation between ion reactivity distribution and friction force distribution within a single region was determined to examine the effect of the distribution of binder on the electrochemical strain.
The research team explored the electrochemical strain microscopy amplitude/phase and lateral force microscopy friction force dependence on the AC drive voltage and the tip loading force, and used their sensitivities as markers for each component in the composite anode.
This method allows for direct multiscale observation of the composite electrode in ambient condition, distinguishing various components and measuring their properties simultaneously.
Lead author Dr. Hongjun Kim said, “It is easy to prepare the test sample for observation while providing much higher spatial resolution and intensity resolution for detected signals.” He added, “The method also has the advantage of providing 3D surface morphology information for the observed specimens.”
Professor Seungbum Hong from the Department of Material Sciences and Engineering said, “This analytical technique using atomic force microscopy will be useful for quantitatively understanding what role each component of a composite material plays in the final properties.”
“Our method not only will suggest the new direction for next-generation all-solid-state battery design on a multiscale basis but also lay the groundwork for innovation in the manufacturing process of other electrochemical materials.”
This study is published in ACS Applied Energy Materials and supported by the Big Science Research and Development Project under the Ministry of Science and ICT and the National Research Foundation of Korea, the Basic Research Project under the Wearable Platform Materials Technology Center, and KAIST Global Singularity Research Program for 2019 and 2020.
Publication:Kim, H, et al. (2020) ‘Visualization of Functional Components in a Lithium Silicon Titanium Phosphate-Natural Graphite Composite Anode’. ACS Applied Energy Materials, Volume 3, Issue 4, pp. 3253-3261. Available online at https://doi.org/10.1021/acsaem.9b02045
Profile:
Seungbum Hong
Professor
seungbum@kaist.ac.kr
http://mii.kaist.ac.kr/
Materials Imaging and Integration Laboratory
Department of Material Sciences and Engineering
KAIST
2020.05.22 View 8678 -
Professor Youngchul Kim Joins Presidential Commission on Architecture Policy
Professor Youngchul Kim from the Department of Civil and Environmental Engineering, who is also the Director of the Smart City Research Center at KAIST, was appointed as a commissioner of the 6th Presidential Commission on Architecture Policy on May 19. Professor Kim will contribute to coordinating and deliberating national architecture and urban development policies. He will serve a two-year term beginning this month.
The Presidential Commission on Architecture Policy is made up of 30 commissioners. Nineteen members, including Professor Kim, are experts from the private sector, and the rest include the Minister of Land, Infrastructure, and Transport, the Minister for Environment, and other government officials. The non-governmental commissioners represent a diverse mixture of genders, ages, and regions for the balanced development of the nation.
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2020.05.21 View 5799 -
Highly Efficient Charge-to-Spin Interconversion in Graphene Heterostructures
Researchers present a new route for designing a graphene-based active spintronic component
KAIST physicists described a route to design the energy-efficient generation, manipulation and detection of spin currents using nonmagnetic two-dimensional materials. The research team, led by Professor Sungjae Cho, observed highly efficient charge-to-spin interconversion via the gate-tunable Rashba-Edelstien effect (REE) in graphene heterostructures.
This research paves the way for the application of graphene as an active spintronic component for generating, controlling, and detecting spin current without ferromagnetic electrodes or magnetic fields.
Graphene is a promising spintronic component owing to its long spin diffusion length. However, its small spin-orbit coupling limits the potential of graphene in spintronic applications since graphene cannot be used to generate, control, or detect spin current.
“We successfully increased the spin-orbit coupling of graphene by stacking graphene on top of 2H-TaS2, which is one of the transition metal dichalcogenide materials with the largest spin-orbit coupling. Graphene now can be used to generate, control, and detect spin current,” Professor Cho said.
The Rashba-Edelstein effect is a physical mechanism that enables charge current-to-spin current interconversion by spin-dependent band structure induced by the Rashba effect, a momentum-dependent splitting of spin bands in low-dimensional condensed matter systems.
Professor Cho’s group demonstrated the gate-tunable Rashba-Edelstein effect in a multilayer graphene for the first time. The Rahsba-Edelstein effect allows the two-dimensional conduction electrons of graphene to be magnetized by an applied charge current and form a spin current. Furthermore, as the Fermi level of graphene, tuned by gate voltage, moves from the valence to conduction band, the spin current generated by graphene reversed its spin direction.
This spin reversal is useful in the design of low-power-consumption transistors utilizing spins in that it provides the carrier “On” state with spin up holes (or spin down electrons) and the "Off" state with zero net spin polarization at so called “charge neutrality point” where numbers of electrons and holes are equal.
“Our work is the first demonstration of charge-to-spin interconversion in a metallic TMD (transition-metal dichalcogenides) and graphene heterostructure with a spin polarization state controlled by a gate. We expect that the all-electrical spin-switching effect and the reversal of non-equilibrium spin polarization by the application of gate voltage is applicable for the energy-efficient generation and manipulation of spin currents using nonmagnetic van der Waals materials,” explained Professor Cho.
This study (https://pubs.acs.org/doi/10.1021/acsnano.0c01037) was supported by the National Research Foundation of Korea.
Publication:
Lijun Li, Jin Zhang, Gyuho Myeong, Wongil Shin, Hongsik Lim, Boram Kim, Seungho Kim, Taehyeok Jin, Stuart Cavill, Beom Seo Kim, Changyoung Kim, Johannes Lischner, Aires Ferreira, and Sungjae Cho, Gate-Tunable Reversible Rashba−Edelstein Effect in a Few-Layer Graphene/2H-TaS2 Heterostructure at Room Temperature. ACS Nano 2020. Link to download the paper: https://pubs.acs.org/doi/10.1021/acsnano.0c01037
Profile:
Professor Sungjae Cho, PhD
sungjae.cho@kaist.ac.kr
http://qtak.kaist.ac.kr
Department of Physics
Korea Advanced Institute of Science and Technology (KAIST)
https://www.kaist.ac.kr
Daejeon 34141, Korea
2020.05.18 View 8347 -
Breastfeeding Helps Prevent Mothers from Developing Diabetes after Childbirth
A team of South Korean researchers found that lactation can lower the incidence and reduce the risk of maternal postpartum diabetes. The researchers identified that lactation increases the mass and function of pancreatic beta cells through serotonin production. The team suggested that sustained improvements in pancreatic beta cells, which can last for years even after the cessation of lactation, improve mothers’ metabolic health in addition to providing health benefits for infants.
Pregnancy imposes a substantial metabolic burden on women through weight gain and increased insulin resistance. Various other factors, including a history of gestational diabetes, maternal age, and obesity, further affect women’s risk of progressing to diabetes after delivery, and the risk of postpartum diabetes increases more in women who have had gestational diabetes and/or repeated deliveries.
Diabetes-related complications include damage to blood vessels, which can lead to cardiovascular and cerebrovascular diseases such as heart attack and stroke, and problems with the nerves, eyes, kidneys, and many more. Since diabetes can pose a serious threat to mothers’ metabolic health, the management of maternal metabolic risk factors is important, especially in the peripartum period. Previous epidemiological studies have reported that lactation reduces the risk of postpartum diabetes, but the mechanisms underlying this benefit have remained elusive.
The study, published in Science Translational Medicine on April 29, explains the biology underpinning this observation on the beneficial effects of lactation. Professor Hail Kim from the Graduate School of Medical Science and Engineering at KAIST led and jointly conducted the study in conjunction with researchers from the Seoul National University Bundang Hospital (SNUBH) and Chungnam National University (CNU) in Korea, and the University of California, San Francisco (UCSF) in the US.
In their study, the team observed that the milk-secreting hormone ‘prolactin’ in lactating mothers not only promotes milk production, but also plays a major role in stimulating insulin-secreting pancreatic beta cells that regulate blood glucose in the body.
The researchers also found that ‘serotonin’, known as a chemical that contributes to wellbeing and happiness, is produced in pancreatic beta cells during lactation. Serotonin in pancreatic beta cells act as an antioxidant and reduce oxidative stress, making mothers’ beta cells healthier. Serotonin also induces the proliferation of beta cells, thereby increasing the beta cell mass and helping maintain proper glucose levels.
The research team conducted follow-up examinations on a total of 174 postpartum women, 85 lactated and 99 non-lactated, at two months postpartum and annually thereafter for at least three years. The results demonstrated that mothers who had undergone lactation improved pancreatic beta cell mass and function, and showed improved glucose homeostasis with approximately 20mg/dL lower glucose levels, thereby reducing the risk of postpartum diabetes in women. Surprisingly, this beneficial effect was maintained after the cessation of lactation, for more than three years after delivery.
Professor Kim said, “We are happy to prove that lactation benefits female metabolic health by improving beta cell mass and function as well as glycemic control.”
“Our future studies on the modulation of the molecular serotonergic pathway in accordance with the management of maternal metabolic risk factors may lead to new therapeutics to help prevent mothers from developing metabolic disorders,” he added.
This work was supported by grants from the National Research Foundation (NRF) and the National Research Council of Science and Technology (NST) of Korea, the National Institutes of Health (NIH), the Larry L. Hillblom Foundation, and the Health Fellowship Foundation.
Image credit: Professor Hail Kim, KAIST
Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Publication:
Moon, J. H et al. (2020) ‘Lactation improves pancreatic β cell mass and function through serotonin production.’ Science Translational Medicine, 12, eaay0455. Available online at https://doi.org/10.1126/scitranslmed.aay0455
Profile: Hail Kim, MD, PhD
hailkim@kaist.edu
Associate Professor
Graduate School of Medical Science and Engineering (GSMSE)
Korea Advanced Institute of Science and Technology (KAIST)
Profile: Hak Chul Jang, MD, PhD
janghak@snu.ac.kr
Professor
Division of Endocrinology and Metabolism
Seoul National University Bundang Hospital (SNUBH)
President
Korean Diabetes Association
Profile: Joon Ho Moon, MD, PhD
moonjoonho@gmail.com
Clinical Fellow
Division of Endocrinology and Metabolism
SNUBH
Profile: Hyeongseok Kim, MD, PhD
hskim85kor@gmail.com
Assistant Professor
Chungnam National University (CNU)
Profile: Professor Michael S. German, MD
Michael.German@ucsf.edu
Professor
Diabetes Center
University of California, San Francisco (UCSF)
(END)
2020.04.29 View 16131 -
Long Economic Depressions and Disparities Loom in the Wake of the COVID-19
"Global Cooperation for Managing Data Key to Mitigating the Impacts Around the World"
<Full recorded video of the GSI-IF2020>
The COVID-19 pandemic will lead to long economic depressions around the entire world. Experts predicted that the prevalent inequities among the countries, regions, and individuals will aggravate the economic crisis. However, crises always come with new opportunities and international cooperation and solidarity will help creating a new normal in the post-coronavirus era.
In a very basic but urgent step, global cooperation for managing data is the key to respond to COVID-19 since medicine and healthcare are intertwined with data science, said experts during an online international forum hosted by the Global Strategy Institute at KAIST on April 22.
KAIST launched its think-tank, the Global Strategy Institute (GSI), in February. The GSI aims to identify global issues proactively and help make breakthroughs well aligned with solid science-based policies.
The inaugural forum of the GSI focused on how the COVID-19 pandemic would impact socio-economic, scientific, and political landscapes, under the theme “Global Cooperation in the Coronavirus Era.”
In his opening remarks, KAIST President Sung-Chul Shin stressed that future global governance will be dominated by the power of science and technology. “If we can implement efficient policies together with troubleshooting technology for responding to future crises, we will emerge stronger than before,” he said.
President Shin said ‘the Korean model’, which is being recognized as a shining example for dealing with the pandemic, is the result of collaborations combining the creativity of the private sector, the public sector’s strong infrastructure, and the full support of the citizens. He added, “Without the technological prowess coming from the competent R&D power of Korea, we could not achieve these impressive results.”
“Creative collaboration among the private and public sectors, along with research universities from around the world, will help shore up global resilience against the epidemic. We should work together to build a world of growing prosperity,” President Shin said.
Prime Minister Sye-Kyun Chung, who is in charge of the Central Disaster and Safety Countermeasures Headquarters in Korea, stressed global solidarity in his welcoming remarks, saying that “We need to share information and rely on the strength of our connections, rather than retreating into nationalistic isolation.”
Peter Lee, Vice President of the Microsoft Healthcare, pointed out in his welcoming remarks three critical sectors for global cooperation: medicine and healthcare, public health and prevention, and life and the economy. He emphasized the rule of thumb for managing data, saying that data in these fields should be open, standardized, and shared among countries to combat this global pandemic.
During a keynote session, Director General of the International Vaccine Institute (IVI) Jerome Kim described the challenges that go along with developing a vaccine. Dr. Kim said that only 7% of vaccine candidates go through the clinical trial stages, and it will take five to 10 years to completely prove a new vaccine’s safety after completing three stages of clinical tests.
“It’s very challenging to develop the vaccine for COVID-19 within 12 to 15 months,” said Dr. Kim. He added that 78 out of 115 candidates are currently undergoing clinical trials around the world.
There are five groups, including Moderna, Inovio, Jenner Institute, CanSino, and the Beijing Institute of Biological Products, who are doing clinical trials in phases 1 and 2. “Given the fact that COVID-19 is a totally new type of virus, various stakeholders’ participation, such as the National Immunization Technical Advisory Groups, the WHO, and UNICEF, is needed to work together to benefit the entire world,” he pointed out.
Professor Edward Yoonjae Choi from the Graduate School of AI at KAIST shared how AI and data sciences are being utilized to interpret the major trends of the epidemic. His group mainly focuses on deep learning to model electronic health records (EHR) for disease predictions. Professor Choi said AI and machine learning would be crucial solutions and collaborative research projects will surely accelerate how quickly we can overcome the pandemic.
In addition, Dr. Kijung Shin’s group is interpreting the SIR (Susceptible, Infected, and Recovered) model in Korea to predict the number of infections and when people were infected. However, researchers noticed that they could not see the typical modeling in Korea for predicting the number of infections since the model disregarded the new variable of humans’ efforts to stop the spread the virus.
According to research by Professor Steven Whang’s group on social distancing and face mask distribution among vulnerable age groups, people in their 20s, 60s, and 70s followed the social distancing guidelines the most strictly. The research team analyzed the data provided by SK Telecom in the Gangnam district of Seoul. The data provided on people in their 70s, a group that accounted for half of all fatalities, showed that masks were generally well distributed nationwide.
Dr. Alexandros Papaspyrids, Tertiary Education Industry Director of the Asia region of Microsoft, said that despite all the disadvantages and problems related to remote education, we shouldn’t expect to return to the days before the COVID-19 any time soon. “We should accept the new normal and explore new opportunities in the new educational environment,” he said.
Hongtaek Yong, Deputy Minister at the Office of R&D Policy at the Ministry of Science and ICT presented the Korean government’s disease prevention and response policy and how they tried to mitigate the economic and social impact.
He stressed the government’s fast testing, tracing, and openness for successfully flattening the curve, adding that the government used an ICT-based approach in all aspects of their response. From early this year when the first patient was reported, the government aggressively encouraged the biotech industry to develop diagnostic kits and novel therapeutic medications.
As a result, five companies were able to produce genetic diagnostic reagents through the emergency approval. More notably, four of them are conducting massive R&D projects sponsored by the government and this is the result of the government’s continuous investment in R&D. Korea is the leader in R&D investment among the OECD countries.
According to Yong, the government’s big data project that was launched in 2017 continuously traces the trends of epidemics in Korea. The epidemiological studies based on the paths taken by suspected patients using credit card transaction made the difference in predicting the spread of the coronavirus and implementing countermeasures. The data has been provided to the Korea’s Center for Disease Control (CDC).
“In addition to the epidemics, we have so many other pending issues arising from digital and social equities, un-contact services, and job security. We are very open to collaborate and cooperate with other countries to deal with this global crisis,” Yong said.
During the subsequent panel discussions, David Dollar, a senior fellow at the Brookings Institution, said, “The global economy in the coronavirus era will not have a rapid V-shaped recovery, but rather will fall into a long depression for at least two years.” He pointed out that if countries practice protectionism like they did during the Great Depression, the recession will be even worse. Hence, he urged the international community, especially developed nations, to avoid protectionism, consider the economic difficulties of developing countries, and provide them with financial support.
Co-Director of the Center for Universal Education at the Brookings Institution Rebecca Winthrop raised concerns over the recent shift to online teaching and learning, claiming that insufficient infrastructures in low-income families in developing nations are already causing added educational disparities and provoking the inequity issue around the world. “The ways to provide quality education equally through faster and more effective means should be studied,” she said.
Professor Joungho Kim, the director of the KAIST GSI and the forum’s organizer, concluded the event by saying that this forum will be a valuable resource for everyone who is providing assistance to those in need, both during and after the COVID-19 pandemic.
(END)
2020.04.22 View 18327