RNA
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New BioFactory Technique Developed using sRNAs
Professor Sang Yup Lee
- published on the online edition of Nature Biotechnology. “Expected as a new strategy for the bio industry that may replace the chemical industry.”-
KAIST Chemical & Biomolecular engineering department’s Professor Sang Yup Lee and his team has developed a new technology that utilizes the synthetic small regulatory RNAs (sRNAs) to implement the BioFactory in a larger scale with more effectiveness.
* BioFactory: Microbial-based production system which creates the desired compound in mass by manipulating the genes of the cell.
In order to solve the problems of modern society, such as environmental pollution caused by the exhaustion of fossil fuels and usage of petrochemical products, an eco-friendly and sustainable bio industry is on the rise. BioFactory development technology has especially attracted the attention world-wide, with its ability to produce bio-energy, pharmaceuticals, eco-friendly materials and more.
For the development of an excellent BioFactory, selection for the gene that produces the desired compounds must be accompanied by finding the microorganism with high production efficiency; however, the previous research method had a complicated and time-consuming problem of having to manipulate the genes of the microorganism one by one.
Professor Sang Yup Lee’s research team, including Dr. Dokyun Na and Dr. Seung Min Yoo, has produced the synthetic sRNAs and utilized it to overcome the technical limitations mentioned above.
In particular, unlike the existing method, this technology using synthetic sRNAs exhibits no strain specificity which can dramatically shorten the experiment that used to take months to just a few days.
The research team applied the synthetic small regulatory RNA technology to the production of the tyrosine*, which is used as the precursor of the medicinal compound, and cadaverine**, widely utilized in a variety of petrochemical products, and has succeeded developing BioFactory with the world’s highest yield rate (21.9g /L, 12.6g / L each).
*tyrosine: amino acid known to control stress and improve concentration
**cadaverine: base material used in many petrochemical products, such as polyurethane
Professor Sang Yup Lee highlighted the significance of this research: “it is expected the synthetic small regulatory RNA technology will stimulate the BioFactory development and also serve as a catalyst which can make the chemical industry, currently represented by its petroleum energy, transform into bio industry.”
The study was carried out with the support of Global Frontier Project (Intelligent Bio-Systems Design and Synthesis Research Unit (Chief Seon Chang Kim)) and the findings have been published on January 20th in the online edition of the worldwide journal Nature Biotechnology.
2013.02.21 View 11786 -
Op-Ed by Prof. David Helfman: Global Science and Education in the 21st Century
Professor David Helfman from the Department of Biological Sciences and Graduate School of Nanoscience and Technology(https://sites.google.com/site/cellsignalinglaboratory/home) recently wrote an Op-Ed in the January 2013 issue of Journal of Happy Scientists and Engineers that ispublished by the Ministry of Science, Education and Technology, the Republic of Korea. In the article entitled “Global Science and Education in the 21st Century,” Professor Helfman addressed three important issues in science and education, which will have a great impact for the development of world-leading universities in Korea. For the article, please see the attachment.
2013.01.22 View 12662
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High Efficiency Bio-butanol production technology developed
KAIST and Korean Company cooperative research team has developed the technology that increases the productivity of bio-butanol to equal that of bio-ethanol and decreases the cost of production.
Professor Lee Sang Yeop (Department of Biological-Chemical Engineering) collaborated with GS Caltex and BioFuelChem Ltd. to develop a bio-butanol production process using the system metabolism engineering method that increased the productivity and decreased the production cost.
Bio-butanol is being widely regarded as the environmentally friendly next generation energy source that surpasses bio-ethanol.
The energy density of bio-butanol is 29.9MJ (mega Joule) per Liter, 48% larger than bio-ethanol (19.6MJ) and comparable to gasoline (32MJ). Bio-butanol is advantageous in that it can be processed from inedible biomass and is therefore unrelated to food crises.
Especially because bio-butanol shows similar characteristics especially in its octane rating, enthalpy of vaporization, and air-fuel ratio, it can be used in a gasoline engine.
However barriers such as difficulty in gene manipulation of producer bacterium and insufficient information prevented the mass production of bio-butanol.
Professor Lee’s team applied the system metabolism engineering method that he had invented to shift the focus to the production pathway of bio-butanol and made a new metabolism model.
In the new model the bio-butanol production pathway is divided into the hot channel and the cold channel.
The research team focused on improving the efficiency of the hot channel and succeeded in improving the product yield of 49% (compared to theoretical yield) to 87%.
The team furthered their research and developed a live bio-butanol collection and removal system with GS Caltex. The collaboration succeeded in producing 585g of butanol using 1.8kg of glucose at a rate of 1.3g per hour, boasting world’s highest concentration, productivity, and rate and improving productivity of fermentation by three fold and decreasing costs by 30%.
The result of the research was published in world renowned ‘mBio’ microbiology journal.
2012.12.21 View 9477
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KAIST International Students Organize KAIST ONE Program
International Students at KAIST are running a program called “KAIST ONE” (Overseas Networking Exchange) in order to promote an active exchange between students and to present their cultures.
Originally an international cultural activity at the ICU (then the Information and Communications University) in 2007, the program changed its name to “KAIST ONE” and was continued after the merging of the university with KAIST. Students of about 40 different countries have participated to date, and each annual event attracts more than 150 students.
Over 700 international students from 70 different countries around the world spontaneously organize and manage the KAIST ONE program, which is run five times this semester, every other Thursday from 7p.m. to 9p.m. at the KAIST International Center.
The 11th of last month and the 1st of this month witnessed an enthusiastic response from about 150 participants who joined the Columbian and the Saudi Arabian students in introducing their cultures, presenting traditional cultural performances, and sharing traditional foods.
The next in line are Danish, Ugandan, and Cameroonian students who are set to have their turns on this month’s 15th, 29th, and next month’s 6th, respectively.
Also notable is the active attention and support from foreign embassies such as the participation of Tunisian, Brazilian, Pakistani, Azerbaijani, Thai, and German ambassadors in the program since last year to provide food and introductory guides to cultures.
The director of this year’s program, Karim Charfi (Tunisian, 3rd year Electrical Engineering) said, “During the selection stage of each semester, everyone competes for the chance to present their country,” and “KAIST ONE has established itself as a unique and exotic cultural event at KAIST since it networks about 40 of the relatively less known countries such as Uganda, Cameroon, Tunisia, and Chile and the people with diverse cultures.”
The supervisor of the program, Chang Dong Yoo of the Office of Special Projects and Institutional Relations said, “KAIST ONE is an opportunity for international students to acquaint people with their cultures, and it is also a site of cultural exchange and of building friendships among KAIST students and international students,” and “we plan to extend the event such that not only the KAIST members but also the local residents can join in.”
The program welcomes KAIST students as well as the general public.
2012.12.21 View 8225
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Novel material that prevents health decline with age found
Professor Kim Dae Soo (Department of Biological Science), his research team, the Choong Nam University Medicine School, and various companies conducted collaborative research succeeded in developing a novel material that prevents health decline with age. The result was published in PLoS One Journal with the title “Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice”.
Longevity and health can be obtained with reducing consumption of food and aerobic exercise.
Professor Kim’s team focused on the fact that reduced consumption of food and aerobic exercise increase the coenzyme (NAD+) which suppresses the aging of cells. The research team discovered that by activating NQO1 enzyme with Beta-lapachone, the amount of NAD+ in the body increases even without reduction of food consumption or aerobic exercise.
Even consumption of Beta-lapachone by aging mice caused an improved on the brain and exercise ability of the mice. It is expected that commercialization of Beta-lapachone will be possible as it is a chemical that is commonly found in herbs used in both the orient and the oxidant.
2012.12.21 View 7796
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KAIST shocks the world with its creativity
Researchers at KAIST yielded great results at the world’s leading international Human Computer Interaction Society.
Professor Lee Gi Hyuk’s (Department of Computer Sciences) and Professor Bae Seok Hyung’ (Department of Industrial Design) respective teams received awards in two criteria in student innovation contest and was the only domestic university that presented their thesis at the ACM Symposium on User Interface Software.
The ACM UIST holds a student innovation contest prior to its opening. This year’s topic was the pressure sensing multi touch pad of Synaptics and involved 27 prestigious universities including MIT and CMU.
The KAIST team (Ki Son Joon Ph.D. candidate, Son Jeong Min M.A. candidate of Department of Computer Sciences and Woo Soo Jin M.A. candidate of Department of Industrial Design) designed a system that allows modulated control by attaching a simple structure to the pressure sensing multi touch pad.
The second KAIST team (Huh Seong Guk Ph.D. candidate, Han Jae Hyun Ph.D. candidate, Koo Ji Sung Ph.D. candidate at the Department of Computer Sciences, and Choi Ha Yan M.A. candidate at Department of Industrial Design) designed a system that utilizes a highly elastic fiber to allow the sensing of lateral forces. They also created a slingshot game application which was the second most popular system.
In the thesis session Professor Bae’s team (Lee DaWhee Ph.D. candidate, Son Kyung Hee Ph.D. candidate, Lee Joon Hyup M.A. candidate at Department of Industrial Design) presented a thesis that dealt with the technology that innovated the table pen for displays.
The new ‘phantom pen’ solved the issue arising from the hiding effect of the pen’s contact point and the display error due to the thickness of the display. In addition the ‘phantom pen’ has the ability to show the same effects as crayons or markers in a digital environment.
2012.11.29 View 11427
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International Forum on Electric Vehicles 2012
KAIST hosted the International Forum on Electric Vehicles 2012 was held on the 7th of November.
IFEV provided the opportunity for domestic and international front runners of future transportation technology research to come together and discuss the direction and possibility of commercialization of electric vehicles.
The keynote speaker of the forum was Hong Soon Man Director of Korea Railroad Research Institute. Lectures were given by distinguished speakers including Kim Gyung Chul Director of Korea Transportation Research Institute, Takashi Ohira Professor at Toyohashi University of Technology, Tomoyuki Shinkai Professor at Keio University, Christian Kobel Director of Development at Germany’s Bombardier, and Peter Burggraef Professor at Rheinisch University of Technology.
Four topics will be debated on: Future road vehicles and wireless power technology, future high speed railway system, future maritime transportation system, and strategy and policy for green transportation technology.
The IFEV is expected to yield a positive result by allowing government, academia, and industry to come together and discuss the direction of future transportation technology and its social implications.
Detailed information can be found at http://gt.kaist.ac.kr/ifev2012/
2012.11.29 View 8242
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'KAIST ONE" program run by international students
International Students at KAIST are currently running the ‘KAIST ONE (Overseas Networking Exchange)’ program which promotes cultural exchange with other students.
The program started in 2007 at ICU and continues on as the ‘KAIST ONE’ event, after the school was integrated into KAIST. Students from over 40 different nationalities have participated in the program and an average of 150 students participates in each event.
The ‘KAIST ONE’ event is held every other Thursday at the KAIST international center from 7 to 9pm. Columbian and Saudi Arabian students hosted the event in October and November respectively and displayed their traditional culture and food. Students from Denmark, Uganda and Cameroon will host the event on November 15th, 19th and on December 6th respectively.
Since last year, the event has received great interest from many different embassies, with foreign ambassadors participating in the events.
Karim Charfi (Tunisia, Junior at the Department of Electrical Engineering), who planned the event, said that “KAIST ONE is a great opportunity to introduce foreign to other students” and that “it has become a unique event that can only be experienced at KAIST”.
Anyone can participate in the program, from KAIST students to outsiders.
2012.11.22 View 9104 -
Education 3.0: a change from teaching to learning
On October 16th, educationalists and Presidents from research-oriented universities around the world gathered in Seoul to attend the 2012 International Presidential Forum on Global Research Universities, where KAIST introduced its new smart learning model ‘Education 3.0’.
Smart learning ‘Education 3.0’ allows students to learn from lectures given by renowned scholars through the internet and encouraged student to professor discussion. This technology was created to deal with the ever-changing classroom dynamics due to the advancement of IT technology.‘Education 3.0’ differs from the traditional teaching-based lectures in that it offers a platform for self-directed learning. KAIST is working to spread ‘Education 3.0’ by providing specialized classrooms and running an online learning platform that complements it.
This spring, KAIST adopted ‘Education 3.0’ in 3 courses and received high praise from students (a rating of 4.4 out of 5.0). Hence, the number of courses was extended to 10 this fall.
Through this gathering, KAIST hopes to develop cooperative connections between foreign universities to share learning platforms and contents. On October 16th, KAIST signed a MOU with Denmark’s Danmarks Tekniske Universitet (DTU) to provide a cyber-dual degree program using ‘Education 3.0’. Hence, students studying Web science and Digital Media in either KAIST or DTU can receive degrees from both schools without physically visiting them.
President Suh said that “‘Education 3.0’ provides a new paradigm of learning which moves from the tradition cramming method of teaching to self-directed learning” and that this model will help the globalization of KAIST by initiating global cooperation with foreign universities.
Over 60 Universities from 27 different countries attended the forum, including ULCA and Caltech from the United States, DTU from Denmark, University of Southampton and University of York from England, University of Queensland from Australia, Nanyang Technological University from Singapore and Tokyo Institute of Technology from Japan. Members from Korean Universities such as Hanyang University, Handong Global University, Sogang University and Sookmyung Women"s University also attended.
2012.10.25 View 11105 -
DNA based semiconductor technology developed
Professor Park Hyun Gyu’s research team from the Department of Chemical and Biomolecular Engineering at KAIST has successfully implemented all logic gates using DNA, a feat that led the research to be published as the cover paper for the international nanotechnology paper "Small".
Even with the latest technology, it was impossible to create a silicon based semiconductor smaller than 10nm, but because DNA has a thickness of only 2nm, this could lead to the creation of semiconductors with groundbreaking degrees of integration.
A 2 nm semiconductor will be able to store 10,000 HD movies within a size of a postage stamp, at least 100 times more than the current 20nm semiconductors.
DNAs are comprised of 4 bases which are continually connected: Adenine (A) with Thymine (T), and Guanine (G) with Cytosine (C).
For this research, the team used the specific binding properties of DNA, which forms its helix-shape, and a circular molecular beacon that has fluorescent signaling properties under structural changes.
The research team used input signals to open and close the circular DNA, the same principle that is applied to logic gates in digital circuits.
The output signal was measured using the increase and decrease of the fluorescent signal from the molecular beacon due to the opening and closing of the circular DNA respectively.
The team overcame the limited system problems of the existing logic gates and managed to implement all 8 logic gates (AND, OR, XOR, INHIBIT, NAND, NOR, XNOR, IMPlCATION). A multilevel circuit that connects different logic gates was also tested to show its regenerative properties.
Professor Park said that “cheap bio-electric devices with high degrees of integration will be made possible by this research” and that “there will be a large difference in the field of molecular level electronic research”
Mr. Park Gi Su, a doctoral candidate and the 1st author of this research, said that “a DNA sequence of 10 bases is only 3.4nm long and 2nm thick, which can be used to effectively increase the degree of integration of electronic devices” and that “a bio computer could materialize in the near future through DNA semiconductors with accurate logic gates”.
XOR Gate: The output signal 1 comes through the open circular DNA when either input DNA A or input DNA B is present. When both inputs are not present, the flourescent signal does not come through
2012.09.27 View 10208 -
Lee Su Young President of Gwang Won Industries Donates Real Estate worth 7 Million USD
On the 14th of September Lee Su Young President of Gwang Won Industries (since 1988) donated her entire personal real estate in Los Angeles worth 7 million USD.
President Lee commented that “the strength of Science and Technology is the strength behind the development of Korea and I am certain that KAIST is the driving force” and the she “wishes to help out on the nurture of excellent intellectuals”.
“I have led a frugal life, working hard and buying real estate in America. Wealth is not something that you can take beyond death so I always spent rationally in order to return my accumulated wealth back to society. I pondered what would be best for the development of Korea and without a moment’s hesitation I chose KAIST.”
President Lee was touched by the drive for innovation by President Seo and the members of KAIST working day and night for the development of KAIST.
“It was very moving to see a world renowned scholar like President Seo working tirelessly for the past six years to resurrect and develop KAIST. If KAIST continues to develop at such a pace then I am sure that KAIST will become a world class university. Donating to KAIST was sure to be equivalent to donating the Korea.”
President Lee led a life more frugal and most and yet she did not have even a moment’s hesitation in donating her entire fortune.
“My only wish is to see my donation help the students of KAIST with their studies. What more could I expect from them if they become outstanding servants of Korea.”
President Lee graduated from Gyungi Girl’s High School and majored Law in Seoul National University and worked as a newspaper reporter from 1963 to 1980.
She is the President of Gwang Won Industries which began as Gwang Won Ranch in 1971, and is also the Head Board Member at Seoul National University’s Scholarship Foundation for the College of Law.
The donation will be used to fund the ‘KAIST-Lee Su Young International Education Program’ which encompasses the currently under test Education 3.0 program which will allow for the next generation student led education system using multimedia services.
2012.09.22 View 7941
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Professor Yoon Dong Ki becomes first Korean to Receive the Michi Nakata Prize
Professor Yoon Dong Ki (Graduate School of Nano Science and Technology) became the first Korean to receive the Michi Nakata Prize from the International Liquid Crystal Society.
The Awards Ceremony was held on the 23rd of August in Mainz, Germany in the 24th Annual International Liquid Crystal Conference.
The Michi Nakata Prize was initiated in 2008 and is rewarded every two years to a young scientist that made a ground breaking discovery or experimental result in the field of liquid crystal. Professor Yoon is the first Korean recipient of the Michi Nakata Prize.
Professor Yoon is the founder of the patterning field that utilizes the defect structure formed by smectic displays. He succeeded in large scale patterning complex chiral nano structures that make up bent-core molecules.
Professor Yoon’s experimental accomplishment was published in the Advanced Materials magazine and the Proc. Natl. Acad. Sci. U.S.A. and also as the cover dissertation of Liquid Crystals magazine.
Professor Yoon is currently working on Three Dimensional Nano Patterning of Supermolecular Liquid Crystal and is part of the World Class University organization.
2012.09.11 View 12824