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The thermal fluctuation and elasticity of cell membranes, lipid vesicles, interacting with pore-forming peptides were reported by a research team at KAIST.
A research team from KAIST, consisted of Sung-Min Choi, Professor of Nuclear and Quantum Engineering Department, and Ji-Hwan Lee, a doctoral student in the Department, published a paper on the “thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides.” The paper was carried by Physical Review Letters, an internationally renowned peer-review journal on physics on July 16, 2010.
Cell membranes, which consist of lipid bilayers, play important roles in cells as barriers to maintain concentrations and matrices to host membrane proteins. During cellular processes such as cell fission and fusion, the cell membranes undergo various morphological changes governed by the interplay between protein and lipid membranes. There have been many theoretical and experimental approaches to understand cellular processes driven by protein-lipid membrane interactions. However, it is not fully established how the membrane elastic properties, which play an important role in membrane deformation, are affected by the protein-membrane interactions.
Antimicrobial peptides are one of the most common examples of proteins that modify membrane morphology. While the pore-forming mechanisms of antimicrobial peptides in lipid bilayers have been widely investigated, there have been only a few attempts to understand the mechanisms in terms of membrane elastic properties. In particular, the effects of pore formation on the membrane fluctuation and elastic properties, which provide key information to understand the mechanism of antimicrobial peptide activity, have not been reported yet. The research team reports the thermal fluctuation and elasticity of lipid vesicles interacting with pore-forming peptides, which were measured by neutron spin-echo spectroscopy.
The results of this study are expected to pay an important role in understanding the elastic behavior and morphological changes of cell membranes induced by protein-membrane interactions, and may provide new insights for developing new theoretical models for membrane fluctuations which include the membrane mediated interaction between protein patches.
(a) (b)
Figure
(a) Schematics for bound melittin and pores in lipid bilayers
(b) P NMR signal ratio (with/without Mn2+) of DOPC LUV-melittin vs P/L at 30˚C. The dashed line is a guide for eyes.
2010.07.23 View 11181 -
A new facility at KAIST opened on July 6, 2010.
Ryu Geun-Chul Sports Complelx will allow students, faculty and staff to pause a moment and exhale in the hustle and bustle of their daily lives.
An opening ceremony celebrating the completion of a new facility for the KAIST family was held on July 6, 2010 at the campus. Had it not been for contributions of many people and organizations throughout the nation, among others, Dr. Geun-Chul Ryu, POSCO, Woori Bank, members of KAIST community, parents, and other citizens, it would be impossible to build the facility, said the university.
The Complex, a three-story building with a basement, has an indoor court for basketball and volleyball with 3,000 individual seats, 200 meters of running track, indoor golf range, a fitness center, and other convenient facilities.
Any members of KAIST community can visit the building and relax their body and mind stressed with work and study. It also provides a large space for ceremonial and cultural gatherings such as 2010 KAIST commencement ceremony.
The official name of the building is “Ryu Geun-Chul Sports Complelx,” which was created in appreciation of Dr. Geun-Chul Ryu’s generous act who had donated 57.8 billion won worth of real estate to KAIST in August 2008.
2010.07.07 View 11897 -
New drug targeting method for microbial pathogens developed using in silico cell
A ripple effect is expected on the new antibacterial discovery using “in silico” cells
Featured as a journal cover paper of Molecular BioSystems
A research team of Distinguished Professor Sang Yup Lee at KAIST recently constructed an in silico cell of a microbial pathogen that is resistant to antibiotics and developed a new drug targeting method that could effectively disrupt the pathogen"s growth using the in silico cell.
Hyun Uk Kim, a graduate research assistant at the Department of Chemical and Biomolecular Engineering, KAIST, conducted this study as a part of his thesis research, and the study was featured as a journal cover paper in the February issue of Molecular BioSystems this year, published by The Royal Society of Chemistry based in Europe.
It was relatively easy to treat infectious microbes using antibiotics in the past. However, the overdose of antibiotics has caused pathogens to increase their resistance to various antibiotics, and it has become more difficult to cure infectious diseases these days.
A representative microbial pathogen is Acinetobacter baumannaii. Originally isolated from soils and water, this microorganism did not have resistance to antibiotics, and hence it was easy to eradicate them if infected. However, within a decade, this miroorganism has transformed into a dreadful super-bacterium resistant to antibiotics and caused many casualties among the U.S. and French soldiers who were injured from the recent Iraqi war and infected with Acinetobacter baumannaii.
Professor Lee’s group constructed an in silico cell of this A. baumannii by computationally collecting, integrating, and analyzing the biological information of the bacterium, scattered over various databases and literatures, in order to study this organism"s genomic features and system-wide metabolic characteristics. Furthermore, they employed this in silico cell for integrative approaches, including several network analysis and analysis of essential reactions and metabolites, to predict drug targets that effectively disrupt the pathogen"s growth. Final drug targets are the ones that selectively kill pathogens without harming human body.
Here, essential reactions refer to enzymatic reactions required for normal metabolic functioning in organisms, while essential metabolites indicate chemical compounds required in the metabolism for proper functioning, and their removal brings about the effect of simultaneously disrupting their associated enzymes that interact with them.
This study attempted to predict highly reliable drug targets by systematically scanning biological components, including metabolic genes, enzymatic reactions, that constitute an in silico cell in a short period of time.
This research achievement is highly regarded as it, for the first time, systematically scanned essential metabolites for the effective drug targets using the concept of systems biology, and paved the way for a new antibacterial discovery. This study is also expected to contribute to elucidating the infectious mechanism caused by pathogens.
"Although tons of genomic information is poured in at this moment, application research that efficiently converts this preliminary information into actually useful information is still lagged behind. In this regard, this study is meaningful in that medically useful information is generated from the genomic information of Acinetobacter baumannii," says Professor Lee. "In particular, development of this organism"s in silico cell allows generation of new knowledge regarding essential genes and enzymatic reactions under specific conditions," he added.
This study was supported by the Korean Systems Biology Project of the Ministry of Education, Science and Technology, and the patent for the development of in silico cells of microbial pathogens and drug targeting methods has been filed.
[Picture 1 Cells in silico]
[Picture 2 A process of generating drug targets without harming human body while effectively disrupting the growth of a pathogen, after predicting metabolites from in silico cells]
2010.04.05 View 14587 -
New Text Book on Chemistry Published by KAIST Professor and Student
A chemistry textbook written in English and Korean will aid Korean students to learn General Chemistry in a global academic setting.
Korean students majoring in chemistry and looking for an opportunity to study abroad will have a new, handy textbook that presents them with a practical introduction to an English speaking lecture on general chemistry.
Aiming for advanced Korean high school and college/university students, the inter-language textbook is written by two incumbent professors teaching chemistry at a university in Korea and the US. The book will help Korean students prepare for a classroom where various topics of general chemistry are presented and discussed in English. Clear, collated sections of English and Korean text provide the student with sufficient explanation of the rudimentary topics and concepts.
Composed of 15 chapters on the core subjects of General Chemistry, i.e., Stoichiometry and Chemical Reactions, Thermochemistry, Atomic Structure, and Bonding, the textbook includes essential English vocabulary and usage sections for each chapter; it also contains a pre-reading study guide on the subject that prepares the student for listening to a lecture. This section includes view-graph type slides, audio files, and follow-up questions the student can use to prepare for an English-speaking course. The various accompanying audio files are prepared to expose the student to English scientific dialogue and serve as examples for instruction at Korean secondary and tertiary schools.
The book was coauthored by Korean and American scientists: A father and son, who have taught chemistry at an American and Korean university, wrote the book. Professor Melvyn R. Churchill at the State University of New York at Buffalo and Professor David G. Churchill at KAIST prepared all of the technical English text which was adapted from General Chemistry course lecture notes; the text was further shaped by original perspectives arising from many student interactions and questions.
This English text was translated into Korean by Professor Kwanhee Lee from the Department of Life and Food Science at Handong Global University, who coauthored a previous preparatory book for Korean students in a different subject. He also supplied an important introductory section which serves as a general guide to the classroom student. Kibong Kim, a doctoral student in the Department of Chemistry at KAIST, helped in preparing the book as well.
“This has been definitely a collaborative undertaking with an international academic crew and it underscores that the Korean internationalization in science is mainstream. Professors and a Korean student created a new book for Korean consumption and benefit,” Professor David G. Churchill says.
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Bibliography: “How to Prepare for General Chemistry Taught in English” by David George Churchill, Melvyn Rowen Churchill, Kwanhee Lee & Kibong Kim, Darakwon Publishing, Paju, Republic of Korea, 2010, 400 pp, ISBN 978-89-5995-730-9 (1 Audio CD included)
2010.04.02 View 13454
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Prof. Lee"s Team Succeeds in Producing Plastics Without Use of Fossil Fuels
A team of scientists led by Prof. Sang-Yup Lee of the Department of Biological Sciences at KAIST have succeeded in producing the polymers used for everyday plastics through bioengineering, rather than through the use of fossil fuel based chemicals, the university authorities said on Tuesday (Nov. 24).
This groundbreaking research, which may now allow for the production of environmentally conscious plastics, has been published in two papers in the journal Biotechnology and Bioengineering.
Polymers are molecules found in everyday life in the form of plastics and rubbers. The team consisted of scientists from KAIST and Korean chemical company LG Chem focused their research on polylactic acid (PLA), a bio-based polymer which holds the key to producing plastics through natural and renewable resources.
"The polyesters and other polymers we use everyday are mostly derived from fossil oils made through the refinery or chemical process," said Lee. "The idea of producing polymers from renewable biomass has attracted much attention due to the increasing concerns of environmental problems and the limited nature of fossil resources. PLA is considered a good alternative to petroleum based plastics as it is both biodegradable and has a low toxicity to humans."
Until now PLA has been produced in a two-step fermentation and chemical process of polymerization, which is both complex and expensive. Now, through the use of a metabolically engineered strain of E.coli, the team has developed a one-stage process which produces polylactic acid and its copolymers through direct fermentation. This makes the renewable production of PLA and lactate-containing copolymers cheaper and more commercially viable.
"By developing a strategy which combines metabolic engineering and enzyme engineering, we"ve developed an efficient bio-based one-step production process for PLA and its copolymers," said Lee. "This means that a developed E. coli strain is now capable of efficiently producing unnatural polymers, through a one-step fermentation process,"
This combined approach of systems-level metabolic engineering and enzyme engineering now allows for the production of polymer and polyester based products through direct microbial fermentation of renewable resources.
"Global warming and other environmental problems are urging us to develop sustainable processes based on renewable resources," concluded Lee. "This new strategy should be generally useful for developing other engineered organisms capable of producing various unnatural polymers by direct fermentation from renewable resources".
2009.11.30 View 13847 -
World Research University Heads Discuss Challenges in Global Financial Turmoil at 2009 International Presidential Forum in Seoul
Leaders of the world"s major research universities discussed the impact of the global economic crisis on institutions of higher learning and their research activities in particular and exchanged opinions and visions on ways to increase cooperation with governments and industry at a symposium organized by KAIST Monday (Sept. 21) at the Westin Chosun Hotel in Seoul.
More than 50 participants of the 2nd International Presidential Forum on Global Research Universities represented institutions in North America, Europe, Southeast Asia, Australia, China and Japan. They were joined by 20 presidents of Korean universities and two dozens of leaders from industry and the government.
Under the main subject of "Challenges to Global Research Universities," the international symposium proceeded in four panel sessions. The subjects of each session and their keynote speakers were:
-- "Institutional Management in Times of Financial Crisis" by Kurt Kutzler, President of Berlin Institute of Technology
-- "Innovations in Education & Research" by Brian Cantor, Vice Chancellor of University of York
-- "Globalization of Institutes of Higher Learning" by Gary Schuster, Provost and Executive Vice President of Georgia Institute of Technology
-- "The Roles of Government, University and Industry in Green Technology Development" by KAIST President Nam-Pyo Suh
KAIST President Suh expressed deep gratitude to all participants for their presentations focused on how universities weathered the difficulties from the economic turmoil and how they were continuing efforts for innovation in research and education. He observed that the 2009 International Presidential Forum was again most successful and productive after the first in 2008 and offered a precious opportunity for leaders of research universities to establish effective networking among their institutions.
"The world has witnessed a global financial turmoil of unseen magnitude and many nations are still struggling under the devastating impacts. While universities were no exception in facing economic turmoil, they have realized renewed pressures and expectations from their respective communities to provide answers to the great challenges,” he said in his welcoming remarks.
"The conference I am sure will have a far-reaching influence on the course our research universities will take to shoulder greater responsibilities for building a better future of the mankind."
Some of the participants in the 2009 International Presidential Forum came to KAIST’s Daejeon campus to take part in the EEWS (energy, environment, water and sustainability) workshop which was held on Tuesday, Sept. 22.
The Chronicle of Higher Learning, the Washington-based newspaper specializing in university education, reported from Seoul that the Forum revealed that, while American universities struggle amid the harshest economic climate in a generation, institutions in much of the rest of the world are sheltered from the fallout by strong government backing.
“Delegates to a conference of university presidents (in Seoul on Monday, Sept. 22) heard that colleges in Asia and Europe are pushing ahead with expansion plans – even as their U.S. counterparts cut back.
“The 2009 International Presidential Forum… was marked by a sharp divide in the tone set by European, Asian, and U.S. college leaders. The Americans often sounded a deeply gloomy note,” The Chronicle reported. “Never before has the impact been this bad,” the paper quoted Vishwanath Prasad, vice president for research and economic development at the University of North Texas, as saying.
On the other hand, Yves Poilane, vice president of the Paris Institute of Technology, said, according to The Chronicle, “The largely state financing of most European universities has so far acted as a shelter, and higher education remains a priority for both European and French Universities.”
The Korea Herald, published in Seoul, said in its Sept. 23 editorial:
“This week in Seoul, a symposium of leaders from international and Korean research universities heard top scholars and administrators reveal how their schools have suffered through the year under reduced government subsidies and private endowments which forced them to postpone various globalization schemes and cut down on research expenditures. Applications for master"s and Ph.D. programs declined while large percentages of graduates failed to find jobs.
“With their country showing a rapid pace of recovery, universities in Korea are in a better situation than many of their overseas counterparts, especially considering the substantial government outlays for research and development in "low carbon, green growth" projects that are largely dependent on research universities. The more the government seeks their direct contributions, the harder universities should try to increase transparency and accountability in the use of taxpayer money, so as not to betray the nation"s trust in them.
“In the wake of the global economic crisis, academia, government and industry find themselves in closer ties as they share new concepts of innovation and development in a common quest for growth. The tripartite cooperation has new significance in the recovery process. To achieve any development objectives, the other two partners must prioritize the funding of universities.”
2009.09.24 View 12671 -
Prof. Lee"s Team Pioneers Biotechnological Production of Chemical Using Renewable Materials
A research team led by Prof. Sang-Yup Lee of the Bio and Brain Engineering Department at KAIST has succeeded in engineering the bacterium E. coli to produce the industrial chemical putrescine, university authorities said on Monday (Aug. 31).
Putrescine, a four carbon chain diamine, is an important platform chemical with a wide range of applications for the pharmaceutical, agrochemical and chemical industries. It is currently used to synthesize nylon-4,6, a widely used engineering plastic.
The research result, published in the Biotechnology and Bioengineering journal, proviDrdes a renewable alternative to the traditional process using fossil fuels.
Currently the production of putrescine on an industrial scale relies on chemical synthesis, which requires non-renewable petrochemicals and expensive catalyst systems. This process is highly toxic and flammable with potentially severe repercussions for both the environment and human health.
"For the first time we have developed a metabolically engineered E. coli strain that efficiently produces putrescine," said Professor Lee. "The development of a bio-refinery for chemicals and materials is very important in a world where dependency on fossil fuels is an increasing concern."
The team developed a strain of E.coli capable of producing putrescine through metabolic engineering. This is where a cell"s metabolic and regulatory networks are enhanced in order to increase production of a needed material.
First the team weakened or deleted competing metabolic pathways within the E. coli strain before deleting pathways which cause putrescine degradation. They also amplified the crucial enzyme Spec C, which converts the chemical ornithine into putrescine. Finally the putrescine exporter, which allows excretion of intracellularly made putrescine, was engineered while a global regulator was engineered to further increase the concentration of putrescine. The final result of this process was an engineered E.coli strain which produced 24.2 g of putrescine per litre.
However, as it was believed that putrescine is toxic to microorganisms the team had to study putrescine tolerance in E.coli before it could be engineered to overproduce the chemical to the levels needed for industrial production.
The results revealed that E. coli can tolerate at least 0.5 M of putrescine, which is tenfold higher than the usual concentration in the cell. This level of tolerance was an important surprise as it means that E. coli can be engineered to overproduce putrescine to industrially competitive levels.
"The previously expected toxicity of putrescine may explain why its microbial production has been overlooked," said Lee. "Now a metabolically engineered E. coli strain has been developed which is capable of efficiently producing putrescine using renewable methods to an industrial level. This metabolic engineering framework should be useful for developing metabolically engineered microorganisms for the efficient production of other chemicals from renewable resources," he added.
2009.09.01 View 12874 -
KAIST Undergraduates Open Four-Day International Conference
The ICISTS-KAIST, an annual international conference organized by KAIST undergraduate students, opened on Thursday (Aug. 20) at the KAIST"s main campus in Daejeon.
The 2009 ICISTS (International Conference for the Integration of Science and Technology into Society) drew around 200 experts and students from 44 countries. Since its inception in 2005 to promote discourse on important science and technology issues affecting modern society, the conference has served as an opportunity for academic networking among students in various parts of the world.
The four-day conference consists of lectures, open discussions among lecturers and students, field trips to help students to understand actual applications, and team projects.
This year"s conference offers three workshops under the themes of "Climate Change: Merging Technology and Policy for Green Solutions"; "Human-Computer Interaction: Designing Computer System for Intuitive Human Access"; and "Nano Clinic: Breakthrough in Conquering Disease."
Lectures by invited experts in various scientific fields will help broaden students" perspectives particularly from interdisciplinary viewpoints, said an organizer of the conference.
2009.08.28 View 13508
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Transparent Antenna for Automobile Developed
A research team led by Prof. Jae-Woo Park of the School of Electrical Engineering & Computer Science, KAIST, developed a transparent antenna for the next-generation automobiles, university authorities said on Monday (Aug. 17).
The development was made possible through joint researches with the Hyundai-Kia Automotive Group; Winncom, a car antenna manufacturer; and a group of researchers led by Han-Ki Kim of the Department of Display Materials Engineering at Kyung Hee University in Seoul.
The transparent antennas were developed in two kinds -- one for the HSDPA (High-Speed Downlink Packet Access), a new protocol for mobile telephone data transmission, and the other for transmitting and receiving radio wave for emergency call.
Using the transparent electrically conductive film formation technology, the transparent antennas are to be mounted on the windshield of a vehicle.
"The development of transparent antenna represents a step forward for the advancement of the next-generation automotive electronic technology," said Seong-woo Kim, a senior researcher at the Hyundai-Kia Group.
2009.08.18 View 12320 -
KAIST's OLEV Best Model of Creative Growth Engine
Various models of electric vehicles designed to replace the internal combustion automobiles face significant problems as they invariably failed to overcome the limitations involving lithium battery in terms of power capacity, weight, raw materal price, recharging time and preparation of charging stations. Worst of all, the limited supply of lithium will eventually raise its price sky high when all cars use lithium batteries, and the economic value of electric cars will be lost.
KAIST"s online electric vehicle project (OLEV) seeks to resolve these fundamental problems involving electric vehicles that have so far been developed. KAIST OLEV, a project to develop a new growth engine for the nation and lead the future of global automotive industry, is an entirely new concept: the electric vehicle picks up power from underground power supplier lines through the non-contact magnetic charging method, while either running or standing. This is the first eco-friendly and economic automotive system that can resolve the problems inherent to previously-developed electric vehicles, according to the KAIST OLEV Project Center.
In February 2009, KAIST researchers first proved that up to 80 percent power conveyance is possible through a gap of 1 centimeter from the power line, and in July they successfully supplied power to a bus -- up to 60 percent across a 12 cm gap from the power line embedded in the ground -- using power supply and pick-up devices they developed. In this process, KAIST has secured the core technologies for maximizing power efficiency and minimizing the cost of installing the non-contact power supply system. KAIST has established the Online Electric Vehicle Co., Ltd., to undertake business activities related to the OLEV project, including the IPR on power supply and pick-up devices, parts and accessories and commercial promotion. A demonstration event is scheduled for Aug. 13, Thursday.
The impact of the development of the OLEV technology on the energy and environment issues and the overall economy will be enormous. In case a half of the total automobiles running in Korea, or 6 million vehicles, are replaced with OLEV, electric power produced by just two of the nation"s atomic power plants will be enough to operate them all, and the nation will be able to reduce crude oil import by 35 million barrels worth U.S.$3 billion a year (supposing $80 per barrel).
Korea"s export of OLEV units will in the future surpass the present level of overseas sale of conventional cars. When nations use online electric vehicles in large numbers, their demand for CO2-free power plants will grow. Korea has cutting-edge technology in the construction of atomic power plants. As a world leader in the area of nuclear power plant, Korea will enjoy new opportunities to contribute to the global advancement of atomic power generation as well as transportation industries.
Korea still shares a small portion of the world"s automobile market estimated to worth some 2,000 trillion Korean won. But commercialization of the OLEV technology worldwide will greatly enhance Korea"s global automotive market share. Successful development of the online electric vehicle requires preemptive investment and positive support by the government for the ultimate purpose of resolving energy and environment problems.
If and when domestic enterprises secure technological supremacy in the next generation automobile market with their online electric vehicles which will replace the 100-year-old combustion engine, it will be the most desirable shortcut to raising Korea"s international competitiveness. OLEV promises to be the model of creative growth engine in the 21st century.
2009.07.30 View 15880
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Prof. Park to Receive HP's Annual Innovation Research Award
Prof. In-Kyu Park of the Department of Mechanical Engineering, KAIST, has been will receive an award from Hewlett-Packard"s second annual Labs Innovation Research Program, university authorities said on Wednesday (July 8).
Prof. Park was chosen as the winner of the research award for his paper entitled "Eco-friendly nanomanufacturing for intelligent environment sensing applications."
Sixty projects from 46 universities in 12 countries were selected as the recipients of the awards from HP Labs, the company"s central research arm. The program is designed to create opportunities for colleges, universities and research institutes to conduct collaborative research with HP.
HP Labs Innovation Research Awards provide project funding of up to $100,000 for one year to each of the chosen academic institutions, which is renewable for up to three years based on research progress and HP business requirements.
Prof. Park has conducted joint researches on nanoimprinting, nanosensors, and nanoelectronics with HP"s Information and Quantum Systems Lab since 2005. Starting from the later half of 2009, he is to receive research grants under the industry-academia cooperation program of the world"s information technology giant firm.
2009.07.09 View 12745 -
KAIST President Suh Honored with 2009 ASME Medal
KAIST President Nam-Pyo Suh has chosen as the 2009 winner of the ASME Medal presented by the American Society of Mechanical Engineers, university authorities said on Thursday (July 2).
President Suh received the honor for "seminal contributions to the advancement of engineering through research in tribology, polymer processing, metal processing, design and manufacturing, as well as contributions to engineering education and research infrastructure."
The selection of President Suh was unanimously approved by the 13-member Board of Governors of the ASME. Suh became the first scientist of Asian descent in the award"s 89-year-long history.
Founded in 1880, the ASME is a non-profit professional organization promoting the art, science and practice of mechanical and multidisciplinary engineering and allied sciences. The organization is known for setting codes and standards for mechanical devices. As of 2009, it has 120,000 members worldwide.
Only one ASME medal is awarded annually to recognize "eminently distinguished achievement." The award consists of a $17,000 honorarium, a gold medal, certificate and travel supplement for two days. It will be presented to President Suh during the 2009 International Mechanical Engineering Congress and Exposition, which will be held in Lake Buena Vista, Florida, November 13-10, 2009.
President Suh is an internationally known educator, engineer and inventor. Born in Korea, he immigrated to the U.S. in 1954 to join his father, who was teaching at Harvard. He earned both his bachelor"s and master"s degrees from MIT before coming to Carnegie Tech for his doctoral education in mechanical engineering.
While teaching at MIT, he founded the MIT-Industry Polymer Processing Program in 1973 and the Laboratory for Manufacturing and Productivity. He left these positions in 1984 to serve with the U.S. National Science Foundation as its assistant director for engineering, until 1988.
He invented many new materials, products and manufacturing processes, earning more than 60 U. S. patents and founding several companies. He has written seven books and more than 300 scholarly papers. Among dozens of honors throughout his career, President Suh most recently received the 2007 Lifetime Achievement from the Society of Plastics Engineers.
The ASME conducts one of the world"s largest technical publishing operations through its ASME Press, holds numerous technical conferences and hundreds of professional development courses each year, and sponsors numerous outreach and educational programs.
2009.07.02 View 12676