RNA
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KAIST developed an extremely low-powered, high-performance head-mounted display embedding an augmented reality chip
Walking around the streets searching for a place to eat will be no hassle when a head-mounted display (HMD) becomes affordable and ubiquitous. Researchers at the Korea Advanced Institute of Science and Technology (KAIST) developed K-Glass, a wearable, hands-free HMD that enables users to find restaurants while checking out their menus. If the user of K-Glass walks up to a restaurant and looks at the name of the restaurant, today’s menu and a 3D image of food pop up. The Glass can even show the number of tables available inside the restaurant. K-Glass makes this possible because of its built-in augmented reality (AR) processor. Unlike virtual reality which replaces the real world with a computer-simulated environment, AR incorporates digital data generated by the computer into the reality of a user. With the computer-made sensory inputs such as sound, video, graphics or GPS data, the user’s real and physical world becomes live and interactive. Augmentation takes place in real-time and in semantic context with surrounding environments, such as a menu list overlain on the signboard of a restaurant when the user passes by it, not an airplane flight schedule, which is irrelevant information, displayed. Most commonly, location-based or computer-vision services are used in order to generate AR effects. Location-based services activate motion sensors to identify the user’s surroundings, whereas computer-vision uses algorithms such as facial, pattern, and optical character recognition, or object and motion tracking to distinguish images and objects. Many of the current HMDs deliver augmented reality experiences employing location-based services by scanning the markers or barcodes printed on the back of objects. The AR system tracks the codes or markers to identify objects and then align them with virtual reality. However, this AR algorithm is difficult to use for the objects or spaces which do not have barcodes, QR codes, or markers, particularly those in outdoor environments and thus cannot be recognized. To solve this problem, Hoi-Jun Yoo, Professor of Electrical Engineering at KAIST and his team developed, for the first time in the world, an AR chip that works just like human vision. This processor is based on the Visual Attention Model (VAM) that duplicates the ability of human brain to process visual data. VAM, almost unconsciously or automatically, disentangles the most salient and relevant information about the environment in which human vision operates, thereby eliminating unnecessary data unless they must be processed. In return, the processor can dramatically speed up the computation of complex AR algorithms. The AR processor has a data processing network similar to that of a human brain’s central nervous system. When the human brain perceives visual data, different sets of neurons, all connected, work concurrently on each fragment of a decision-making process; one group’s work is relayed to other group of neurons for the next round of the process, which continues until a set of decider neurons determines the character of the data. Likewise, the artificial neural network allows parallel data processing, alleviating data congestion and reducing power consumption significantly. KAIST’s AR processor, which is produced using the 65 nm (nanometers) manufacturing process with the area of 32 mm2, delivers 1.22 TOPS (tera-operations per second) peak performance when running at 250 MHz and consumes 778 miliWatts on a 1.2V power supply. The ultra-low power processor shows 1.57 TOPS/W high efficiency rate of energy consumption under the real-time operation of 30fps/720p video camera, a 76% improvement in power conservation over other devices. The HMDs, available on the market including the Project Glass whose battery lasts only for two hours, have revealed so far poor performance. Professor Yoo said, “Our processor can work for long hours without sacrificing K-Glass’s high performance, an ideal mobile gadget or wearable computer, which users can wear for almost the whole day.” He further commented:“HMDs will become the next mobile device, eventually taking over smartphones. Their markets have been growing fast, and it’s really a matter of time before mobile users will eventually embrace an optical see-through HMD as part of their daily use. Through augmented reality, we will have richer, deeper, and more powerful reality in all aspects of our life from education, business, and entertainment to art and culture.” The KAIST team presented a research paper at the International Solid-State Circuits Conference (ISSCC) held on February 9-13, 2014 in San Francisco, CA, which is entitled “1.22TOPS and 1.52mW/MHz Augmented Reality Multi-Core Processor with Neural Network NoC for HMD Applications.”Youtube Link: http://www.youtube.com/watch?v=wSqY30FOu2s&feature=c4-overview&list=UUirZA3OFhxP4YFreIJkTtXw
2014.02.20 View 18325 -
World's Largest Web Conference To Be Held in Korea
The 2014 International World Wide Web Conference (WWW 2014), the world’s most prestigious academic conference in the field of web, will be held for the first time in Korea. The conference is to be last for five days at Seoul COEX, from 7th to 11th April. International World Wide Web Conference covers a wide range of web-related areas, including technologies, research papers, services and more. Since the first conference in 1994 in Switzerland, it has been held in various parts of North America, Europe, South America and Asia, attracting more than 1000 experts in the field. The 23rd International World Wide Web Conference is managed by the International World Wide Web Conferences Steering Committee (IW3C2) and co-hosted by KAIST and National Agency for Technology and Standards, as well as sponsored by Korea Information Science Society and the World Wide Web Consortium (W3C). Keynote speakers for this year’s conference include inventor of the World Wide Web, Sir Tim Berners-Lee, senior vice president of Microsoft, Dr. Qi Lu, and Carnegie Mellon University’s Prof. Christos Faloutsos, as well as Samsung Electronic’s vice president Jong-Deok Choi. In addition to WWW 2014, BigData Innovators Gathering (BIG 2014) and Web for Access (W4A 2014) is also to be held in joint. KAIST Computer Sciences Department’s Prof. Jinwan Jeong, in charge of directing this year’s conference, said “From one-sided 1st generation web to two-way 2nd generation web, such as blogs, and then recently to the 3rd generation web, which include social networks and semantic webs, the web technologies has grown vastly over the past 25 years. WWW 2014 will be the opportunity for Korea to discuss with the world about the informatization and future of the web.” Pre-registration for WWW 2014 can be applied at the official webpage for WWW 2014 (http://www2014.kr) before 17th February.
2014.02.14 View 11978 -
Professor Hoi-Jun Yoo Appointed as the First Asian University Chairman of the ISSCC
Hoi-Jun Yoo, a professor of Electrical Engineering Department at KAIST, was chosen to be the first Asian University Chairman of the ISSCC (International Solid-State Circuits Conference) held in San Francisco, USA, from February 10 to 13, 2014. His term will last one year from April, 2014. Professor Yoo ranked tenth globally in thesis achievement over the 60-year history of the ISSCC. He ranked fourth globally over the last ten years and was the highest-ranked member from Asia over that time. He received an award for this remarkable achievement in 2012. ISSC is a world-renowned conference in the semiconductor field, where only 200 strictly selected papers are presented by semiconductor-related enterprises, research centers, and university representatives. Nicknamed the “The Olympics of the Semiconductor”, ISSCC runs for 4 days and hosts more than 3000 semiconductor engineers from around the world. It is most famous for the first CPU presentation by Intel and the first memory technology release of Samsung. Professor Yoo stated, “The Korean Semiconductor Engineering is leading the world’s technology instead of imitating it.” He aspires to devote himself to upgrading semiconductor engineering around the world.
2014.02.14 View 11687 -
ICISTS-KAIST Talk Concert 2014
The International Conference for the Integration of Science, Technology and Society at KAIST (ICISTS-KAIST) will hold a talk entitled “Scientific Technology and Culture” at Youngdungpo Art Hall in Seoul on Tuesday, February 11, 2014.The three main presenters will be: Jin-Hwa Kim, Director of Korbit, Dong-Hyeon Jo, Chief of New Business at Nexon, and media artist Yi-Nam Lee. They will address the meeting of culture and scientific technology in the fields of art, games, and other genres.Jin-Hwa Kim is the director of Korbit, the first Korean bitcoin exchange, and wrote The Next Money: Bitcoin, the world’s first bitcoin textbook. He will elaborate on how science and technology are constantly changing and have affected popular culture, and how public demand gave birth to bitcoin.Dong-Hyeon Jo from Nexon will explain how the appearance of new media and platforms such as smartphones has changed our lives.Media artist Yi-Nam Lee has been described as “the second Nam-June Paik,” an internationally-acclaimed video artist, for his integration of oriental and western masterpieces with modern media. During the event, samples of his artwork will be displayed.ICISTS-KAIST is a student organization which has held a conference every year since 2005 with hundreds of students attending from many parts of the world, Asia in particular.
2014.02.07 View 11806 -
Is it possible to identify rumors on SNS?
Rumors
sporadically spread with people with fewer followers in the centerResearched
over 100 rumors in the US from 2006 to 2009 Is it
possible to filter information on SNS such as Twitter and Facebook? A research
team led by Professor Mee-Young Cha from the Department of Cultural Technology
Graduate School at KAIST, Professor Kyo-Min Jung of Seoul National University,
Doctor Wei Chen and Yajun Wang of Microsoft Asia, has developed a technology
that can accurately filter out information on Twitter to 90% accuracy. The
research not only deduced a new mathematical model, network structure, and
linguistic characteristics on rumors from SNS data, but is also expected to
enhance the effort to make secure technology to regulate Internet rumors. The team
analysed the characteristics of rumors in over 100 widespread cases in the US
from 2006 to 2009 on Twitter. The team gathered data, which included a range of
areas such as politics, IT, health and celebrity gossips, and their analysis
could identify rumors to 90% accuracy. The filtering was more accurate in
rumors that included slanders or insults. The
research team identified three characteristics of the spread of rumors. Firstly,
rumors spread continuously. Normal news spreads widely once and is mentioned
rarely again on media, but rumors tend to continue for years. Secondly,
rumors spread through sporadic participation of random users with no
connections. Rumors start from people with fewer followers and spread to the
more popular. This phenomenon is often observed in rumors concerning
celebrities or politicians. Lastly,
rumors have unique linguistic characteristics. Rumors frequently include words
(such as “it may be true,” “although not certain, I think,” “although I cannot
fully remember”) related to psychological processes that question, deny, or
infer the reliability of the information. Professor
Cha said, “This research deduced not only a statistical and mathematical model
but also is an integrated research on social psychological theory on the
characteristics of rumors that attract great attention from the society based
on ample data.” The results
were made public in IEEE International Conference on Data Mining last December
in Texas, USA.
2014.02.03 View 11595 -
Professor Sang-Min received an award for scholar of the year from the KAISTian of the Year 2013
KAIST nominates a “Scholar of the Year” each year and presents the award to the recipient at a New Year’s opening ceremony. For the year 2013, Professor Sang-Min Bae of the Industrial Design Department at KAIST was named “KAIST Scholar of 2013” and received the award on January 2, 2014.
Professor Bae has been recognized for his design achievement in 2013: D’Light, a kinetic lighting that employs a transformable lampshade using flexible honeycomb structure, became one of the finalists in the living room and bedroom category of the International Design Excellence Award 2013 and was selected one of the best 100 for the 2013 Good Design Award. Users can easily change the shape and light intensity of the lamp by simply pivoting the lampshade with its small handle.
Professor Bae has also actively pursued his own philanthrophic projects through design: he has given the profits from the sales of his designs including D’Light directly toward a scholarship for needy children.
The Scholar of the Year award is presented to a faculty member or researcher at KAIST who has contributed to the advancement of science and technology such as publication of articles with influential research outcomes, invention of breakthrough technology, implementation of outstanding research projects, and improvement of public life. Professor Bae is the 13 th winner of the KAIST award.
The Korea Times, a leading English language newspaper in Korea, published an article on this award. For the article, please visit http://www.koreatimes.co.kr/www/news/people/2014/01/178_149117.html .
2014.01.09 View 12126 -
First International Conference on Science and Technology for Society
KAIST co-organized the 2013 International Conference on Science and Technology for Society which was held on November 28 at the Grace Hall in Seoul EL-Tower. More than 300 people, including members of the Global Social Technology Advisory Board, domestic social technology experts, private companies, government officials, private citizens, and students joined the conference to discuss the roles and responsibilities of science and technology for society.
R&D policies and technologies for solving social issues were introduced, and discussions were held on desirable directions for technological development.
The first speaker, Yasushi Watanabe, Director of RISTEX (Research Institute of Science and Technology for Society) in Japan, introduced the importance of science and technology for society under the title “Change of R&D Paradigm for Society.”
Robert Wimmer, GrAT (Center for Appropriate Technology), Vienna University of Technology in Austria, presented “Need-oriented Design & Solutions for Development.” Kiyoaki Murakami, MRI, Japan, presented “Introduction of Platinum Vision” and Robert Ries, University of Florida, U.S.A., presented “Evaluating the Social Impacts of the Built Environment Using Life Cycle Assessment.”
Case studies on social enterprises and presentations on R&D for solving social problems were introduced by ICISTS (International Conference for the Integration of Science, Technology and Society), which is a student group at KAIST, National Research Foundation of Korea (NRF), Korea Institute of Machinery and Materials (KIMM), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Korea Institute of Industrial Technology (KITECH), Electronics and Telecommunication Research Institute (ETRI), and Korea Research Institute of Chemical Technology (KRICT).The conference was hosted by the Ministry of Science, ICT, and Future Planning and co-organized by NRF, KIMM, KRIBB, KITECH, ETRI and KRICT.
2013.12.11 View 13249 -
UN biological weapons expert gives lecture at KAIST
KAIST’s student organization, the ICISTS Organizing Committee, invited United Nations Security Council expert Terence Taylor to deliver a speech under the topic of ‘Terrorists and Scientists: Biological Weapons and its impact on Global Society’. The lecture took place on November 19 on the Daejeon campus.
Taylor shared his experiences as a biochemical weapons expert at Iraq and discussed the fast-approaching future of the world with biochemical weapons.
Terence Taylor is a former British military officer, who served various governmental and non-governmental organizations around the world, including UK and U.S. agencies, as well as the UN. His current work involves the non-proliferation and disarmament of nuclear or biological weapons, toxic substances and other weapons of mass destruction.
ICISTS Organizing Committee is a student organization run by of KAIST students. Since 2005, it has actively held one of the largest student conferences in Asia, ICISTS-KAIST, at KAIST every year. "ICISTS" stands for “International Conference for the Integration of Science, Technology, and Society”, which conveys its vision in achieving a harmony between science and society.
UN Security Council expert Terence Taylor
2013.11.28 View 10276 -
Kinetic Lighting, Dlight, Dominates World Renowned Design Awards
Professor Sang-Min Bae
“D’light,” a lamp that transforms its lampshade shape, developed by a team led by KAIST Department of Industrial Design’s Professor Sang-Min Bae, won Japan’s Good Design Awards on October the 2nd, soon after winning the internationally renowned 2013 International Design Excellence Awards (IDEA) in August.
IDEA, sponsored by the Industrial Design Society of America (IDSA) and BusinessWeek, awards the best work from over 6,000 exhibits from 50 countries. Japan’s Good Design Awards, founded by the Japan Institute of Design Promotion (JDP) in 1957, is the most prestigious and one of the World’s four major design awards.
“D’light” combines “donative” and “light.” Its meaning originates from the meaning of “delight” which means “giving great joy.” The shape and the brightness of the lamp can be transformed by turning the end of the heart-shaped lampshade. The team states that the lamp carries a figurative meaning of generous hearts lighting the neglected of the world by designing the lamp to be the brightest when it takes the shape of a heart. D’light developed as the 5th product of “the Nanum” project that started in 2006. Professor Bae first participated in the project in developing the 2nd product, “Cross Cube” in 2007. The he designed and launched the environmentally friendly humidifier “Lovepot” in 2008 and interactive tumbler “Hearty” in 2009.
The “Nanum” project aims to develop innovative products for charity to create a humane social circulatory system. The project, led by the international relief and development organisation, World Vision and KAIST’s ID+IM laboratory run by Professor Bae, donates all profits to educate the children of low-income families. The project raised a total of 1.7 billion Korean won from 2007 this year to provide scholarships to 240 children in need.
Professor Bae’s team has undertaken seed and “Nanum” projects with the theme of philanthropy design helping people in need by creating innovative designs. The project has produced four excellent and authentic products which received 44 world renowned design awards.
Professor Bae said, “’The Nanum’ project consists of planning, designing, producing and selling for charity and donates all profit to children in need through education and scholarship.” He continued, “The consumers can purchase products that are aesthetically pleasing and convenient as well as gaining an opportunity to donate to children in need.”
Figure1 Kinetic lighting D’light
Figure 2. Characteristics of “Nanum” D’light
The shape of the lampshade can be transformed. The lamp sheds the brightest light when it takes the shape of a heart, hence showing the figurative meaning of brightening the neglected parts of the world with generous hearts.
Figure 3. Detailed Images of D’light
2013.11.11 View 11366 -
Metabolically engineered E. coli producing phenol
Many chemicals we use in everyday life are derived from fossil resources. Due to the increasing concerns on the use of fossil resources, there has been much interest in producing chemicals from renewable resources through biotechnology.
Phenol is an important commodity chemical, and is a starting material for the production of numerous industrial chemicals and polymers, including bisphenol A and phenolic resins, and others. At present, the production of phenol entirely depends on the chemical synthesis from benzene, and its annual production exceeds 8 million tons worldwide. Microbial production of phenol seems to be a non-viable process considering the high toxicity of phenol to the cell.
In the paper published online in Biotechnology Journal, a Korean research team led by Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering from the Korea Advanced Institute of Science and Technology (KAIST) reported the successful development of an engineered Escherichia coli (E. coli) strain which can produce phenol from glucose. E. coli has been a workhorse for biological production of various value-added compounds such as succinic acid and 1,4-butanediol in industrial scale. However, due to its low tolerance to phenol, E. coli was not considered a viable host strain for the biological production of phenol.
Professor Lee"s team, a leading research group in metabolic engineering, noted the genetic and physiological differences of various E. coli strains and investigated 18 different E. coli strains with respect to phenol tolerance and engineered all of the 18 strains simultaneously. If the traditional genetic engineering methods were used, this work would have taken years to do. To overcome this challenge, the research team used synthetic small RNA (sRNA) technology they recently developed (Nature Biotechnology, vol 31, pp 170-174, 2013). The sRNA technology allowed the team to screen 18 E. coli strains with respect to the phenol tolerance, and the activities of the metabolic pathway and enzyme involved in the production of phenol. The research team also metabolically engineered the E. coli strains to increase carbon flux toward phenol and finally generated an engineered E. coli strain which can produce phenol from glucose.
Furthermore, the team developed a biphasic extractive fermentation process to minimize the toxicity of phenol to E. coli cells. Glycerol tributyrate was found to have low toxicity to E. coli and allowed efficient extraction of phenol from the culture broth. Through the biphasic fed-batch fermentation using glycerol tributyrate as an in situ extractant, the final engineered E. coli strain produced phenol to the highest titer and productivity reported (3.8 g/L and 0.18 g/L/h, respectively). The strategy used for the strain development and the fermentation process will serve as a framework for metabolic engineering of microorganisms for the production of toxic chemicals from renewable resources.
This work was supported by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) of the Ministry of Science, ICT & Future Planning through the National Research Foundation of Korea.
Process of Phenol Production
2013.11.05 View 11443 -
A powerful strategy for developing microbial cell factories by employing synthetic small RNAs
The current systems for the production of chemicals, fuels and materials heavily rely on the use of fossil resources. Due to the increasing concerns on climate change and other environmental problems, however, there has been much interest in developing biorefineries for the production of such chemicals, fuels and materials from renewable resources. For the biorefineries to be competitive with the traditional fossil resource-based refineries, development of high performance microorganisms is the most important as it will affect the overall economics of the process most significantly. Metabolic engineering, which can be defined as purposeful modification of cellular metabolic and regulatory networks with an aim to improve the production of a desired product, has been successfully employed to improve the performance of the cell. However, it is not trivial to engineer the cellular metabolism and regulatory circuits in the cell due to their high complexity.
In metabolic engineering, it is important to find the genes that need to be amplified and attenuated in order to increase the product formation rate while minimizing the production of undesirable byproducts. Gene knock-out experiments are often performed to delete those metabolic fluxes that will consequently result in the increase of the desired product formation. However, gene knock-out experiments require much effort and time to perform, and are difficult to do for a large number of genes. Furthermore, the gene knock-out experiments performed in one strain cannot be transferred to another organism and thus the whole experimental process has to be repeated. This is a big problem in developing a high performance microbial cell factory because it is required to find the best platform strain among many different strains. Therefore, researchers have been eager to develop a strategy that allows rapid identification of multiple genes to be attenuated in multiple strains at the same time.
A Korean research team led by Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering from the Korea Advanced Institute of Science and Technology (KAIST) reported the development of a strategy for efficiently developing microbial cell factories by employing synthetic small RNAs (sRNAs). They first reported the development of such system in Nature Biotechnology last February. This strategy of employing synthetic sRNAs in metabolic engineering has been receiving great interest worldwide as it allows easy, rapid, high-throughput, tunable, and un-doable knock-down of multiple genes in multiple strains at the same time. The research team published a paper online on August 8 as a cover page (September issue) in Nature Protocols, describing the detailed strategy and protocol to employ synthetic sRNAs for metabolic engineering.
In this paper, researchers described the detailed step-by-step protocol for synthetic sRNA-based gene expression control, including the sRNA design principles. Tailor-made synthetic sRNAs can be easily manipulated by using conventional gene cloning method. The use of synthetic sRNAs for gene expression regulation provides several advantages such as portability, conditionality, and tunability in high-throughput experiments. Plasmid-based synthetic sRNA expression system does not leave any scar on the chromosome, and can be easily transferred to many other host strains to be examined. Thus, the construction of libraries and examination of different host strains are much easier than the conventional hard-coded gene manipulation systems. Also, the expression of genes can be conditionally repressed by controlling the production of synthetic sRNAs. Synthetic sRNAs possessing different repression efficiencies make it possible to finely tune the gene expression levels as well. Furthermore, synthetic sRNAs allow knock-down of the expression of essential genes, which was not possible by conventional gene knock-out experiments.
Synthetic sRNAs can be utilized for diverse experiments where gene expression regulation is needed. One of promising applications is high-throughput screening of the target genes to be manipulated and multiple strains simultaneously to enhance the production of chemicals and materials of interest. Such simultaneous optimization of gene targets and strains has been one of the big challenges in metabolic engineering. Another application is to fine tune the expression of the screened genes for flux optimization, which would enhance chemical production further by balancing the flux between biomass formation and target chemical production. Synthetic sRNAs can also be applied to finely regulating genetic interactions in a circuit or network, which is essential in synthetic biology. Once a sRNA scaffold-harboring plasmid is constructed, tailor-made, synthetic sRNAs can be made within 3-4 days, followed by the desired application experiments.
Dr. Eytan Zlotorynski, an editor at Nature Protocols, said "This paper describes the detailed protocol for the design and applications of synthetic sRNA. The method, which has many advantages, is likely to become common practice, and prove useful for metabolic engineering and synthetic biology studies."
This paper published in Nature Protocols will be useful for all researchers in academia and industry who are interested in the use of synthetic sRNAs for fundamental and applied biological and biotechnological studies.
This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012-C1AAA001-2012M1A2A2026556) and the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) of the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea.
2013.10.31 View 10952
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First Prize in the 2013 International Military Science and Technology Contest
Professor James R. Morrison and his students of the Industrial and Systems Engineering Department at KAIST were awarded the first prize in the 2013 International Military Science and Technology Contest organized by the Defense Acquisition Program Administration held in COEX from July 11 to 14.
The research group, Byungduk Song (Ph.D candidate), Jonghoe Kim (Ph.D candidate), Hyolin Park (MS candidate) and Professor James R. Morrison, received the first prize with their paper entitled “Automated and persistent UAV system for a complementary method for border patrol and target tracking.”
The Defense Acquisition Program Administration is the host of the annual contest which aims to contribute to the future of the defense industry and to expand technology exchange between private institutes and the military through the coordination of defense technology and advanced technology from industrial and educational cooperation.Professor Morrison’s team received the honor of the first-place prize out of 56 competitors from within Korea and 7 from overseas in the field of Synthetic New Technology/Academic Thesis.
2013.10.31 View 10345