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Potential Drug to Cure Ciliopathies
(from left: Professor Joon Kim and PhD candidate Yong Joon Kim) Ciliopathies are rare disorders involving functional and structural abnormalities of cilia. Although they are rare, they may reach 1 in 1,000 births. Unfortunately, there are no small-molecule drugs for treating ciliary defects. A KAIST research team conducted successful research that introduces a potential treatment that will be a foundation for developing drugs to treat the disease as well as a platform for developing small-molecule drugs for similar genetic disorders. It was found that mutations in genes required for the formation or function of primary cilia cause ciliopathies and they result in cerebellar disorders, kidney dysfunction, and retinal degeneration. Primary cilia are cell organelles playing a crucial role in the human body. They participate in intercellular signal transduction during embryonic development and allow retinal photoreceptor cells to function. Currently, there are no approved drugs available for treating most ciliopathies. In fact, this is the case for most of the rare genetic disorders involving functional abnormalities through genetic mutation, and gene therapy is usually the only treatment available. To tackle this issue, a team led by Professor Joon Kim from the Graduate School of Medical Science and Engineering and Ho Jeong Kwon from Yonsei University constructed a cell that mimics a gene-mutated CEP290, one of the main causes of ciliopathies, through genome editing. They then used cell-based compound library screening to obtain a natural small-molecule compound capable of relieving defects in ciliogenesis, the production of cilia. The CEP290 protein forms a complex with a ciliopathy protein called NPHP5 to support the function of the ciliary transition zone. In cases where the CEP290 protein is not formed due to a genetic mutation, NPHP5 will not function normally. Here, the compound was confirmed to partially restore the function of the complex by normalizing the function of NPHP5. The team also identified that the compound is capable of retarding retinal degeneration by injecting the compound into animal models. As a result, they discovered a lead compound for developing medication to treat ciliopathy patients involving retinal degeneration. Hence, the findings imply that chemical compounds that target other proteins interacting with the disease protein can mitigate shortages of a disease protein in recessive genetic disorders. PhD candidate Yong Joon Kim stated, “This study shows how genetic disorders caused by genetic mutation can be treated with small-molecule drugs.” Professor Kim said, “Since the efficacy of the candidate drug has been verified through animal testing, a follow-up study will also be conducted to demonstrate the effect on humans.” This research was published in the Journal of Clinical Investigation on July 23. Figure 1. Identification of compounds that rescue ciliogenesis defects caused by CEP290 knockout Figure 2. Eupatilin injection ameliorates M-opsin trafficking and electrophysiological response of cone photoreceptors in rd16 mice
2018.08.30
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Flexible Drug Delivery Microdevice to Advance Precision Medicine
(Schematic view of flexible microdevice: The flexible drug delivery device for controlled release fabricated via inorganic laser lift off.) A KAIST research team has developed a flexible drug delivery device with controlled release for personalized medicine, blazing the path toward theragnosis. Theragnosis, an emerging medical technology, is gaining attention as key factor to advance precision medicine for its featuring simultaneous diagnosis and therapeutics. Theragnosis devices including smart contact lenses and microneedle patches integrate physiological data sensors and drug delivery devices. The controlled drug delivery boasts fewer side-effects, uniform therapeutic results, and minimal dosages compared to oral ingestion. Recently, some research groups conducted in-human applications of controlled-release bulky microchips for osteoporosis treatment. However they failed to demonstrate successful human-friendly flexible drug delivery systems for controlled release. For this microdevice, the team under Professor Daesoo Kim from the Department of Biological Science and Professor Keon Jae Lee from the Department of Materials Science and Engineering, fabricated a device on a rigid substrate and transferred a 50 µm-thick active drug delivery layer to the flexible substrate via inorganic laser lift off. The fabricated device shows mechanical flexibility while maintaining the capability of precise administration of exact dosages at desired times. The core technology is to produce a freestanding gold capping layer directly on top of the microreservoir with the drugs inside, which had been regarded as impossible in conventional microfabrication. The developed flexible drug delivery system can be applied to smart contact lenses or the brain disease treatments by implanting them into cramped and corrugated organs. In addition, when powered wirelessly, it will represent a novel platform for personalized medicine. The team already proved through animal experimentation that treatment for brain epilepsy made progress by releasing anti-epileptic medication through the device. Professor Lee believes the flexible microdevice will further expand the applications of smart contact lenses, therapeutic treatments for brain disease, and subcutaneous implantations for daily healthcare system. This study “Flexible Wireless Powered Drug Delivery System for Targeted Administration on Cerebral Cortex” was described in the June online issue of Nano Energy. (Photo: The flexible drug delivery device for contolled relase attached on a glass rod.)
2018.08.13
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AST Holdings Makes a Donation to KAIST
(KAIST President Sung-Chul Shin and the CEO of AST Holdings, Haegyoo Seo) KAIST President Sung-Chul Shin and the CEO of AST Holdings, Haegyoo Seo, agreed to a partnership on June 27 at the main campus of KAIST. AST Holdings donated one hundred million KRW to the school for fostering experts in the field of augmented reality (AR). The fund will also go to joint research on AR technologies required smart cities. AST Holdings, established in 1997, specializes in developing VR/AR contents. It has collaborated with Samsung Electronics and KIA Motors to produce various digital contents and develop solutions using VR/AR. Research and development carried out by the Augmented Reality Research Center (ARRC) of KAIST aims to foster talented manpower and has accumulated crucial components of technology for contributing to research dissemination. In particular, the ARRC established an industrial, academic, and research partnership that has suggested a new standard for industrial-academic joint research. Under this agreement, an industry assigns its staff to the research center to obtain new technical capabilities while the center strengthens the technological application of a study based on the industrial needs. Through the partnership funds, the center can provide a stable research environment for young researchers and recruit talented manpower from around the world. The center has the potential to become a new model of industrial-academic research platforms that will take a leading role in the field of VR/AR. CEO Seo said, “I would like to take the lead in research on VR/AR-based futuristic city platforms through this partnership with KAIST ARRC and the industrial-academic research program. I hope that this partnership between our company and KAIST will create synergy and secure crucial research, manpower, and basic technology according to our company’s needs. President Shin added, “KAIST will pursue creating an exemplary case of industrial-academic cooperation with outstanding national and international manpower.”
2018.07.02
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Professor Hee-Sung Park Named Scientist of May
(Professor Hee-Sung Park) Professor Hee-Sung Park from the Department of Chemistry was named ‘Scientist of May’ sponsored by the Ministry of Science and ICT and the National Research Foundation of Korea. Professor Park was honored in recognition of his developing a tool to engineer designer proteins via diverse chemical modifications. This approach provides a novel platform for investigating numerous diseases such as cancer and dementia. His research focuses on the production of synthetic proteins and the generation of diverse protein functions as well as the designing and engineering of new translation machinery for genetic code expansion, and the application of synthetic biology techniques for basic cell biology and applied medical science. Post-translational modifications (PTMs) are constantly taking place during or after protein biosynthesis. PTMs play a vital role in expanding protein functional diversity and, as a result, critically affect numerous biological processes. Abnormal PTMs have been known to trigger various diseases including cancer and dementia. Therefore, this technology enables proteins to reproduce with specific modifications at selected residues and will significantly help establish experimental strategies to investigate fundamental biological mechanisms including the development of targeted cancer therapies. Professor Park also received 10 million KRW in prize money.
2018.05.04
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Cross-Generation Collaborative Labs Open
KAIST opened two cross-generation collaborative labs last month. This novel approach will pair up senior and junior faculty members for sustaining research and academic achievements even after the senior researcher retires. This is one of the Vision 2031 innovation initiatives established to extend the spectrum of knowledge and research competitiveness. The selected labs will be funded for five years and the funding will be extended if necessary. KAIST will continue to select new labs every year. A five-member selection committee including the Nobel Laureates Professor Klaus Von Klitzing at the Max-Planck Institute for Solid State Research and Dr. Kurt Wüthrich from ETH Zürich selected the first two labs with senior-junior pairs in March. (Two renowned scholars' Cross-Generation Collaborative Labs which opened last month. Distinguished Professor Lee's lab (above) andChair Professor Sung's lab) Both labs are run by world-renowned scholars: the Systems Metabolic Engineering and Systems Healthcare Laboratory headed by Distinguished Professor Sang-Yup Lee in the Department of Chemical and Biomolecular Engineering and the Acousto-Microfluidics Research Center for Next-Generation Healthcare led by Chair Professor Hyung Jin Sung in the Department of Mechanical Engineering. Distinguished Professor Lee will be teamed up with Professor Hyun Uk Kim, and their lab aims to mass produce new eco-friendly chemical materials as well as higher-value-added materials which will be used for medicine. The new platform technologies created in the lab are expected to provide information which will benefit human healthcare. Meanwhile, the Acousto-Microfluidics Research Center for Next-Generation Healthcare will team up with Professors Hyoungsoo Kim and Yeunwoo Cho under Chair Professor Sung. The lab will conduct research on controlling fluids and objects exquisitely on a micro-nano scale by using high-frequency acoustic waves. The lab plans to develop a next-generation healthcare platform for customized diagnoses as well as disease treatment. KAIST President Sung-Chul Shin, who introduced this novel idea in his research innovation initiative, said that he hopes the Cross-Generation Collaborative Labs will contribute to honoring senior scholars’ research legacies and passing knowledge down to junior researchers in order to further develop their academic achievements. He said, “I sincerely hope the labs will make numerous research breakthroughs in the very near future.”
2018.05.03
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Deep Learning Predicts Drug-Drug and Drug-Food Interactions
A Korean research team from KAIST developed a computational framework, DeepDDI, that accurately predicts and generates 86 types of drug-drug and drug-food interactions as outputs of human-readable sentences, which allows in-depth understanding of the drug-drug and drug-food interactions. Drug interactions, including drug-drug interactions (DDIs) and drug-food constituent interactions (DFIs), can trigger unexpected pharmacological effects, including adverse drug events (ADEs), with causal mechanisms often unknown. However, current prediction methods do not provide sufficient details beyond the chance of DDI occurrence, or require detailed drug information often unavailable for DDI prediction. To tackle this problem, Dr. Jae Yong Ryu, Assistant Professor Hyun Uk Kim and Distinguished Professor Sang Yup Lee, all from the Department of Chemical and Biomolecular Engineering at Korea Advanced Institute of Science and Technology (KAIST), developed a computational framework, named DeepDDI, that accurately predicts 86 DDI types for a given drug pair. The research results were published online in Proceedings of the National Academy of Sciences of the United States of America (PNAS) on April 16, 2018, which is entitled “Deep learning improves prediction of drug-drug and drug-food interactions.” DeepDDI takes structural information and names of two drugs in pair as inputs, and predicts relevant DDI types for the input drug pair. DeepDDI uses deep neural network to predict 86 DDI types with a mean accuracy of 92.4% using the DrugBank gold standard DDI dataset covering 192,284 DDIs contributed by 191,878 drug pairs. Very importantly, DDI types predicted by DeepDDI are generated in the form of human-readable sentences as outputs, which describe changes in pharmacological effects and/or the risk of ADEs as a result of the interaction between two drugs in pair. For example, DeepDDI output sentences describing potential interactions between oxycodone (opioid pain medication) and atazanavir (antiretroviral medication) were generated as follows: “The metabolism of Oxycodone can be decreased when combined with Atazanavir”; and “The risk or severity of adverse effects can be increased when Oxycodone is combined with Atazanavir”. By doing this, DeepDDI can provide more specific information on drug interactions beyond the occurrence chance of DDIs or ADEs typically reported to date. DeepDDI was first used to predict DDI types of 2,329,561 drug pairs from all possible combinations of 2,159 approved drugs, from which DDI types of 487,632 drug pairs were newly predicted. Also, DeepDDI can be used to suggest which drug or food to avoid during medication in order to minimize the chance of adverse drug events or optimize the drug efficacy. To this end, DeepDDI was used to suggest potential causal mechanisms for the reported ADEs of 9,284 drug pairs, and also predict alternative drug candidates for 62,707 drug pairs having negative health effects to keep only the beneficial effects. Furthermore, DeepDDI was applied to 3,288,157 drug-food constituent pairs (2,159 approved drugs and 1,523 well-characterized food constituents) to predict DFIs. The effects of 256 food constituents on pharmacological effects of interacting drugs and bioactivities of 149 food constituents were also finally predicted. All these prediction results can be useful if an individual is taking medications for a specific (chronic) disease such as hypertension or diabetes mellitus type 2. Distinguished Professor Sang Yup Lee said, “We have developed a platform technology DeepDDI that will allow precision medicine in the era of Fourth Industrial Revolution. DeepDDI can serve to provide important information on drug prescription and dietary suggestions while taking certain drugs to maximize health benefits and ultimately help maintain a healthy life in this aging society.” Figure 1. Overall scheme of Deep DDDI and prediction of food constituents that reduce the in vivo concentration of approved drugs
2018.04.18
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KAIST Develops IoT Platform for Food Safety
A research team led by the KAIST Auto-ID Labs developed a GS1 international standard-based IoTs infrastructure platform dubbed Oliot (Open Language of Internet of Things). This platform will be applied to Wanju Local Food, the nation’s largest cooperative, and will be in operation from April 5. A total of eleven organizations participated in the development of Oliot, with KAIST as the center. This consortium is based on the GS1 international standard-based Oliot platform, which allows collecting and sharing data along the entire process of agrifood from production to processing, distribution, and consumption. It aims at increasing farm incomes and establishing a global ecosystem of domestic agriculture and stockbreeding that provides safe food. Wanju Local Food is now the world’s first local food co-op with a traceability system from the initial stage of production planning to end sales based on GS1 international standards, which will ensure food safety. KAIST has been sharing Oliot data in order to apply it to industries around the world. As of April 2018, approximately 900 enterprises and developers from more than 100 countries have downloaded it. Professor Daeyoung Kim from the School of Computing, who is also Research Director of Auto-ID Labs said, “We are planning to disseminate Oliot to local food cooperatives throughout the nation. We will also cooperate with other countries, like China, Holland, and Hong Kong to create a better ecosystem for the global food industry. “We are currently collaborating with related business to converge Oliot with AI or blockchain technology that can be applied to various services, such as healthcare and smart factories. Its tangible outcome will be revealed soon,” he added. Auto-ID Labs are a global research consortium of six academic institutions that research and develop new technologies for advancing global commerce, partnering with GS1 (Global Standard 1), a non-profit organization that established standards for global commerce such as introducing barcodes to the retail industry. The Auto-ID Labs include MIT, University of Cambridge, Keio University, Fudan University, ETH Zurich/University of St. Gallen, and KAIST. The consortium was supported by the Ministry of Science and ICT as well as the Institute for Information and Communications Technology Promotion for three years from 2015. The launching of Oliot at Wanju Local Food will be held on April 5.
2018.04.03
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Open Online Course in Science and Technology, STAR-MOOC
Four universities specializing in science and technology, along with POSTECH and UST, teamed up to establish programs for innovation in education programs, responding to the Fourth Industrial Revolution. KAIST held an opening ceremony for the Science & Technology Advanced Research - Massive Open Online Course (STAR-MOOC) and signed an MoU with GIST, DGIST, UNIST, POSTECH, and UST. STAR-MOOC was launched on February 26 to provide educational service to the public. It is a joint platform where people can take courses featuring lectures from professors from universities specializing in science and technology as well as national research universities. It offers 15 courses covering basics, majors, and electives related to science and technology developed by the STAR-MOOC committee. Students can take a variety of courses. At the opening ceremony, KAIST President Sung-Chul Shin, DGIST President Sang Hyuk Son, UST President Kil Choo Moon, POSTECH Vice President Wankyun Chung, UNIST Vice President Jae Sung Lee, GIST Vice President of Public Affairs Pil-hwan Park came to sign the MoU for provising educational services for the public. During the ceremony, there was also time to introduce a technical agreement with a non-profit organization founded by NAVER, the CONNECT Foundation, for its courses and platform. Universities participating in STAR-MOOC will put effort into capacity building in response to changes driven by the Fourth Industrial Revolution. President Shin said, “STAR-MOOC is a platform that provides science and technology courses from basics to electives and major courses. It will become a leading educational platform.” Students can register and choose courses from the website (http://starmooc.kr).
2018.03.19
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Recognizing Seven Different Face Emotions on a Mobile Platform
(Professor Hoi-Jun Yoo) A KAIST research team succeeded in achieving face emotion recognition on a mobile platform by developing an AI semiconductor IC that processes two neural networks on a single chip. Professor Hoi-Jun Yoo and his team (Primary researcher: Jinmook Lee Ph. D. student) from the School of Electrical Engineering developed a unified deep neural network processing unit (UNPU). Deep learning is a technology for machine learning based on artificial neural networks, which allows a computer to learn by itself, just like a human. The developed chip adjusts the weight precision (from 1 bit to 16 bit) of a neural network inside of the semiconductor in order to optimize energy efficiency and accuracy. With a single chip, it can process a convolutional neural network (CNN) and recurrent neural network (RNN) simultaneously. CNN is used for categorizing and recognizing images while RNN is for action recognition and speech recognition, such as time-series information. Moreover, it enables an adjustment in energy efficiency and accuracy dynamically while recognizing objects. To realize mobile AI technology, it needs to process high-speed operations with low energy, otherwise the battery can run out quickly due to processing massive amounts of information at once. According to the team, this chip has better operation performance compared to world-class level mobile AI chips such as Google TPU. The energy efficiency of the new chip is 4 times higher than the TPU. In order to demonstrate its high performance, the team installed UNPU in a smartphone to facilitate automatic face emotion recognition on the smartphone. This system displays a user’s emotions in real time. The research results for this system were presented at the 2018 International Solid-State Circuits Conference (ISSCC) in San Francisco on February 13. Professor Yoo said, “We have developed a semiconductor that accelerates with low power requirements in order to realize AI on mobile platforms. We are hoping that this technology will be applied in various areas, such as object recognition, emotion recognition, action recognition, and automatic translation. Within one year, we will commercialize this technology.”
2018.03.09
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Low-power, Flexible Memristor Circuit for Mobile and Wearable Devices
(from left: Yunyong Nam, Professor Sung-Yool Choi and Byung Chul Jang) A KAIST research team succeeded in developing an energy efficient, nonvolatile logic-in-memory circuit by using a memristor. This novel technology can be used as an energy efficient computing architecture for battery-powered flexible electronic systems, such as mobile and wearable devices. Professor Sung-Yool Choi from the School of Electrical Engineering and Professor Sang-Hee Ko Park from the Department of Materials Science and Engineering developed a memristive nonvolatile logic-in-memory circuit. Transistor-based conventional electronic systems have issues with battery supply and a long standby period due to their volatile computing architecture. The standby power consumption caused by subthreshold leakage current limits their potential applications for mobile electronic devices. Also, their physical separation of memory and processor causes power consumption and time delay during data transfer. In order to solve this problem, the team developed a logic-in-memory circuit that enables data storage as well as logic operation simultaneously. It can minimize energy consumption and time delay because it does not require data transfer between memory and processor. The team employed nonvolatile, polymer-based memristors and flexible back-to-back Schottky diode selector devices on plastic substrates. Unlike the conventional architecture, this memristive nonvolatile logic-in-memory is a novel computing architecture that consumes a minimal amount of standby power. This one-selector-one memristor (1S-1M) solved the issue of undesirable leakage currents, known as ‘sneak currents’. They also implemented single-instruction multiple-data (SIMD) to calculate multiple values at once. The proposed parallel computing method using a memristive nonvolatile logic-in-memory circuit can provide a low-power circuit platform for battery-powered flexible electronic systems with a variety of potential applications. Professor Choi said, “Flexible logic-in-memory circuits integrating memristor and selector device can provide flexibility, low power, memory with logic functions. This will be a core technology that will bring innovation to mobile and wearable electronic systems.” This research, collaborated with Ph.D. candidates Byung Chul Jang and Yunyong Nam, was published and chosen as the cover of Advanced Functional Materials on January 10. Figure 1. Cover of the Advanced Functional Materials Figure 2. Schematic illustration and cross-sectional TEM image of flexible memristive nonvolatile logic-in-memory circuit Figure 3. Test performance Figure 4. Parallel logic operation within 1S-1M memristor array
2018.02.21
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Finding Human Thermal Comfort with a Watch-type Sweat Rate Sensor
(from left: Professor Young-Ho Cho and Researcher SungHyun Yoon) KAIST developed a watch-type sweat rate sensor. This subminiature device can detect human thermal comfort accurately and steadily by measuring an individual’s sweat rate. It is natural to sweat more in the summer and less in the winter; however, an individual’s sweat rate may vary in a given environment. Therefore, sweat can be an excellent proxy for sensing core body temperature. Conventional sweat rate sensors using natural ventilation require bulky external devices, such as pumps and ice condensers. They are usually for physiological experiments, hence they need a manual ventilation process or high power, bulky thermos-pneumatic actuators to lift sweat rate detection chambers above skin for continuous measurement. There is also a small sweat rate sensor, but it needs a long recovery period. To overcome these problems, Professor Young-Ho Cho and his team from the Department of Bio and Brain Engineering developed a lightweight, watch-type sweat sensor. The team integrated miniaturized thermos-pneumatic actuators for automatic natural ventilation, which allows sweat to be measured continuously. This watch-type sensor measures sweat rate with the humidity rising rate when the chamber is closed during skin contact. Since the team integrated thermos-pneumatic actuators, the chamber no longer needs to be separated manually from skin after each measurement in order for the chamber to ventilate the collected humidity. Moreover, this sensor is wind-resistant enough to be used for portable and wearable devices. The team identified that the sensor operates steadily with air velocity ranging up to 1.5m/s, equivalent to the average human walking speed. Although this subminiature sensor (35mm x 25mm) only weighs 30 grams, it operates continuously for more than four hours using the conventional wrist watch batteries. The team plans to utilize this technology for developing a new concept of cognitive air-conditioning systems recognizing Human thermal status directly; while the conventional air-conditioning systems measuring air temperature and humidity. Professor Cho said, “Our sensor for human thermal comfort monitoring can be applied to customized or smart air conditioners. Furthermore, there will be more demands for both physical and mental healthcare, hence this technology will serve as a new platform for personalized emotional communion between humans and devices.” This research, led by researchers Jai Kyoung Sim and SungHyun Yoon, was published in Scientific Reports on January 19, 2018. Figure1. The fabricated watch-type sweat rate sensor for human thermal comfort monitoring Figure 2. Views of the watch-type sweat rate sensor Figure 3. Operation of the watch-type sweat rate sensor
2018.02.08
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KAIST to Host the THE Innovation & Impact Summit in 2019
KAIST and Times Higher Education (THE) agreed to co-host the THE Innovation & Impact Summit at KAIST from April 1 to 3, 2019. Global leaders from higher education, government, and industry will gather at KAIST to discuss how universities can better innovate for creating a greater impact. (from left: THE Managing Director Trevor Barratt and KAIST President Sung-Chul Shin) President Sung-Chul Shin and Trevor Barratt, managing director at the THE, signed an agreement to host the 2019 THE Innovation & Impact Summit at KAIST next April. The agreement was signed on February 6 during the THE Asia Universities Summit held at SUSTech in Shenzhen in China. Phil Baty, editorial director at the THE was also present during the agreement. By hosting the 2019 THE Innovation & Impact Summit, KAIST has a chance to introduce its innovative research and performance and its educational environment and startup ecosystem to the world. Having educational and industrial leaders meet at KAIST will add more power to the global status and capacity of KAIST. The THE Innovation & Impact Summit, first held in 2017, is one in the seven presidential summit series held by THE. During the second summit at KAIST, THE will launch their world university innovation rankings for the first time. As innovation at universities and its impact have been a crucial indicator in building an institutional brand and reputation, leading universities are gearing up to encourage startups and entrepreneurship education. Even more, innovation at universities is emerging as one of the growth engines of economies. The innovation indicators of KAIST have been highly recognized by many global ranking institutions in terms of the volume of patents and the patents-to-article citation impact. Thomson Reuters has recognized KAIST for two consecutive years as the most innovative university in Asia, and sixth in the world. President Shin has high expectations for the hosting of the Innovation & Impact Summit at KAIST. He explained, “Innovation makes up the DNA of KAIST and it has been our institutional mission from the start in 1971. KAIST was commissioned to make innovation for industrialization and economic development through education and research. I do not see any university more suitable than KAIST to host this innovation summit. I hope the summit at KAIST will serve as a global platform to provide very creative ideas for making innovation and collaboration among the leading universities for all the participants.” Meanwhile, at the THE Asia Universities Summit in Shenzhen, how to respond to the implications of the Fourth Industrial Revolution was the key agenda piercing the two-day sessions. As a panelist, President Shin shared his experiences on innovative strategies viable for spearheading university reform for the Fourth Industrial Revolution, along with Vice-Chancellor of the University of Sheffield Sir Keith Burnett, President of Monash University Margaret Gardner, and President of Hong Kong Polytechnic University President Timothy W. Tong. He said that universities should foster young talents by equipping them with creativity, collaboration, and convergent minds. To swiftly respond to the new industrial environment, President Shin said that universities should remove the high barriers between departments and establish cross- and inter-disciplinary education systems, convergence research and technology commercialization.
2018.02.06
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