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Doctoral Student Receives the Best Paper Award from the International Metabolic Engineering Conference 2016
So Young Choi, a Ph.D. candidate at the Department of Chemical and Biomolecular Engineering at KAIST, received the Student and Young Investigator Poster Award at the 11th International Metabolic Engineering Conference held in Awaji, Japan on June 26-30. Choi received the award for her research on one-step fermentative production of Poly(lactate-co-glycolate) (PLGA) from carbohydrates in Escherichia coli, which was published in the April 2016 issue of Nature Biotechnology. In her paper, she presented a novel technology to synthesize PLGA, a non-natural copolymer, through a biological production process. Because of its biodegradability, non-toxicity, and biocompatibility, PLGA is widely used in biomedical and therapeutic applications, including surgical sutures, prosthetic devices, drug delivery, and tissue engineering. Employing a metabolic engineering approach, Choi manipulated the metabolic pathway of an Escherichia coli bacterium to convert glucose and xylose into the biosynthesis of PLGA within the cell. Previously, PLGA could be obtained only through chemical synthesis. Choi said, “I’m thrilled to receive an award from a flagship conference of my research field. Mindful of this recognition, I will continue my research to produce meaningful results, thereby contributing to the development of science and technology in Korea.” The International Metabolic Engineering Conference is a leading professional gathering where state-of-the-art developments and achievements made in the field of metabolic engineering are shared. With the participation of about 400 professionals from all around the world, the conference participants discussed this year’s theme of “Design, Synthesis and System Integration for Metabolic Engineering.”
2016.07.07
View 11000
KAIST Researchers Receive the 2016 IEEE William R. Bennett Prize
A research team led by Professors Yung Yi and Song Chong from the Electrical Engineering Department at KAIST has been awarded the 2016 William R. Bennett Prize of the Institute of Electrical and Electronics Engineers (IEEE), which is the most prestigious award in the field of communications network. The IEEE bestows the honor annually and selects winning papers from among those published in the past three years for its quality, originality, scientific citation index, and peer reviews. The IEEE award ceremony will take place on May 24, 2016 at the IEEE International Conference on Communications in Kuala Lumpur, Malaysia. The team members include Dr. Kyoung-Han Lee, a KAIST graduate, who is currently a professor at Ulsan National Institute of Science and Technology (UNIST) in Korea, Dr. Joo-Hyun Lee, a postdoctoral researcher at Ohio State University in the United States, and In-Jong Rhee, a vice president of the Mobile Division at Samsung Electronics. The same KAIST team previously received the award back in 2013, making them the second recipient ever to win the IEEE William R. Bennett Prize twice. Past winners include Professors Robert Gallager of the Massachusetts Institute of Technology (MIT), Sachin Katti of Stanford University, and Ion Stoica of the University of California at Berkeley. The research team received the Bennett award for their work on “Mobile Data Offloading: How Much Can WiFi Deliver?” Their research paper has been cited more than 500 times since its publication in 2013. They proposed an original method to effectively offload the cellular network and maximize the Wi-Fi network usage by analyzing the pattern of individual human mobility in daily life.
2016.05.02
View 13431
Non-Natural Biomedical Polymers Produced from Microorganisms
KAIST researchers have developed metabolically engineered Escherichia coli strains to synthesize non-natural, biomedically important polymers including poly(lactate-co-glycolate) (PLGA), previously considered impossible to obtain from biobased materials. Renewable non-food biomass could potentially replace petrochemical raw materials to produce energy sources, useful chemicals, or a vast array of petroleum-based end products such as plastics, lubricants, paints, fertilizers, and vitamin capsules. In recent years, biorefineries which transform non-edible biomass into fuel, heat, power, chemicals, and materials have received a great deal of attention as a sustainable alternative to decreasing the reliance on fossil fuels. A research team headed by Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at KAIST has established a biorefinery system to create non-natural polymers from natural sources, allowing various plastics to be made in an environmentally-friendly and sustainable manner. The research results were published online in Nature Biotechnology on March 7, 2016. The print version will be issued in April 2016. The research team adopted a systems metabolic engineering approach to develop a microorganism that can produce diverse non-natural, biomedically important polymers and succeeded in synthesizing poly(lactate-co-glycolate) (PLGA), a copolymer of two different polymer monomers, lactic and glycolic acid. PLGA is biodegradable, biocompatible, and non-toxic, and has been widely used in biomedical and therapeutic applications such as surgical sutures, prosthetic devices, drug delivery, and tissue engineering. Inspired by the biosynthesis process for polyhydroxyalkanoates (PHAs), biologically-derived polyesters produced in nature by the bacterial fermentation of sugar or lipids, the research team designed a metabolic pathway for the biosynthesis of PLGA through microbial fermentation directly from carbohydrates in Escherichia coli (E. coli) strains. The team had previously reported a recombinant E. coli producing PLGA by using the glyoxylate shunt pathway for the generation of glycolate from glucose, which was disclosed in their patents KR10-1575585-0000 (filing date of March 11, 2011), US08883463 and JP5820363. However, they discovered that the polymer content and glycolate fraction of PLGA could not be significantly enhanced via further engineering techniques. Thus, in this research, the team introduced a heterologous pathway to produce glycolate from xylose and succeeded in developing the recombinant E. coli producing PLGA and various novel copolymers much more efficiently. In order to produce PLGA by microbial fermentation directly from carbohydrates, the team incorporated external and engineered enzymes as catalysts to co-polymerize PLGA while establishing a few additional metabolic pathways for the biosynthesis to produce a range of different non-natural polymers, some for the first time. This bio-based synthetic process for PLGA and other polymers could substitute for the existing complicated chemical production that involves the preparation and purification of precursors, chemical polymerization processes, and the elimination of metal catalysts. Professor Lee and his team performed in silico genome-scale metabolic simulations of the E. coli cell to predict and analyze changes in the metabolic fluxes of cells which were caused by the introduction of external metabolic pathways. Based on these results, genes are manipulated to optimize metabolic fluxes by eliminating the genes responsible for byproducts formation and enhancing the expression levels of certain genes, thereby achieving the effective production of target polymers as well as stimulating cell growth. The team utilized the structural basis of broad substrate specificity of the key synthesizing enzyme, PHA synthase, to incorporate various co-monomers with main and side chains of different lengths. These monomers were produced inside the cell by metabolic engineering, and then copolymerized to improve the material properties of PLGA. As a result, a variety of PLGA copolymers with different monomer compositions such as the US Food and Drug Administration (FDA)-approved monomers, 3-hydroxyburate, 4-hydroxyburate, and 6-hydroxyhexanoate, were produced. Newly applied bioplastics such as 5-hydroxyvalerate and 2-hydroxyisovalerate were also made. The team employed a systems metabolic engineering application which, according to the researchers, is the first successful example of biological production of PGLA and several novel copolymers from renewable biomass by one-step direct fermentation of metabolically engineered E.coli. Professor Lee said, “We presented important findings that non-natural polymers, such as PLGA which is commonly used for drug delivery or biomedical devices, were produced by a metabolically engineered gut bacterium. Our research is meaningful in that it proposes a platform strategy in metabolic engineering, which can be further utilized in the development of numerous non-natural, useful polymers.” Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning of Korea, who oversees the Technology Development Program to Solve Climate Change, said, “Professor Lee has led one of our research projects, the Systems Metabolic Engineering for Biorefineries, which began as part of the Ministry’s Technology Development Program to Solve Climate Change. He and his team have continuously achieved promising results and been attracting greater interest from the global scientific community. As climate change technology grows more important, this research on the biological production of non-natural, high value polymers will have a great impact on science and industry.” The title of the research paper is “One-step Fermentative Production of Poly(lactate-co-glycolate) from Carbohydrates in Escherichia coli (DOI: 10.1038/nbt.3485).” The lead authors are So Young Choi, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at KAIST, and Si Jae Park, Assistant Professor of the Environmental Engineering and Energy Department at Myongji University. Won Jun Kim and Jung Eun Yang, both doctoral students in the Department of Chemical and Biomolecular Engineering at KAIST, also participated in the research. This research was supported by the Technology Development Program to Solve Climate Change’s research project titled “Systems Metabolic Engineering for Biorefineries” from the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF-2012M1A2A2026556). Figure: Production of PLGA and Other Non-Natural Copolymers This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced a variety of PLGAs with different monomer compositions, proposing the chemosynthetic process of non-natural polymers from biomass. The non-natural polymer PLGA and its other copolymers, which were produced by engineered bacteria developed by taking a systems metabolic engineering approach, accumulate in granule forms within a cell.
2016.03.08
View 11809
GSIS Graduates Its First Doctor
The Graduate School of Information Security at KAIST (GSIS) granted its first doctoral degree to Il-Goo Lee at the university’s 2016 commencement on February 19, 2016. Lee received the degree for his dissertation entitled “Interference-Aware Secure Communications for Wireless LANs.” He explained the background of his research: “As we use wireless technology more and more in areas of the Internet of Things (IoT), unmanned vehicles, and drones, information security will become an issue of major concern. I would like to contribute to the advancement of communications technology to help minimize wireless interference between devices while ensuring their optimal performance.” Based on his research, he developed a communications technique to increase wireless devices’ energy efficiency and the level of their security, and created a prototype to showcase that technique. He plans to continue his research in the development of the next generation WiFi chip sets to protect the information security of IoT and wireless devices. Since its establishment in March 2011, KAIST’s GSIS has conferred 50 master’s and one doctoral degrees.
2016.02.18
View 8945
Asia Pacific Biotech News' Special Coverage of Korean Biotechnology
The Asia Pacific Biotech News covered five major biotechnology research projects sponsored by the Korean government in the areas of biofuels, biomedicine, bio-nano healthcare, and biorefinery. The Asia Pacific Biotech News (APBN), a monthly magazine based in Singapore, which offers comprehensive reports on the fields of pharmaceuticals, healthcare, and biotechnology, recently published a special feature on Korea’s biotechnology research and development (R&D) programs. The magazine feature selected five research programs sponsored by the Korean government, which are either part of the Global Frontier or the Climate Change Technology Development Projects. The programs are: Systems Metabolic Engineering Research: Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST) has been leading a research group to develop biorefining technology using renewable non-food biomass to produce chemicals, fuels, and materials that were largely drawn from fossil resources through petrochemical refinery processes. Applying a systems metabolic engineering approach, the group succeeded in modifying the metabolic pathways of microorganisms. As a result, they produced, for the first time in the world, engineered plastic raw materials and gasoline. The team also developed a technique to produce butanol and succinic acid with a higher titer and yield using metabolically engineered microorganisms. Next-generation Biomass Research: Under the leadership of Professor Yong- Keun Chang of the Chemical and Biomolecular Engineering Department at KAIST, the research project, which belongs to the Global Frontier Project, develops biofuels and bioproducts utilizing microalgae typically found in water and other marine systems. Convergence Research for Biomedicine: Professor Sung-Hoon Kim of Seoul National University leads this project that develops targeted new drugs based on convergence research strategies. Bionano Healthcare Chip Research: Director Bong-Hyun Chung of the Korea Research Institute of Bioscience and Biotechnology has integrated information and communications technology, nanotechnology, and biotechnology to develop a diagnostic kit that can screen toxic germs, virus, and toxic materials in a prompt and accurate manner. Biosynergy Research: Led by Professor Do-Hun Lee of the Bio and Brain Engineering Department at KAIST, this research project develops new treatments with a multi-target, multi-component approach in the context of systems biology through an analysis of synergistic reactions between multi-compounds in traditional East Asian medicine and human metabolites. In East Asian medicine, treatment and caring of the human body are considered analogous to the politics of governing a nation. Based on such system, the research focuses on designing a foundation for the integration of traditional medicine with modern drug discovery and development. Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning, Republic of Korea, who is responsible for the Global Frontier Program and the Technology to Solve Climate Change, said, “It is great to see that Asia Pacific Biotech News published an extensive coverage of Korea’s several key research programs on biotechnology as its first issue of this year. I am sure that these programs will lead to great outcomes to solve many worldwide pending issues including climate change and healthcare in the aging society.” Professor Sang Yup Lee, who served as an editor of the feature, said, “At the request of the magazine, we have already published lead articles on our biotechnology research three times in the past in 2002, 2006, and 2011. I am pleased to see continued coverage of Korean biotechnology by the magazine because it recognizes the excellence of our research. Biotechnology has emerged as one of the strong fields that addresses important global issues such as climate change and sustainability.”
2016.02.04
View 12774
IdeasLab Presents Biotechnology Solutions for Aging Populations at 2016 Davos Forum
KAIST researchers will discuss how biological sciences and health technologies can address challenges and opportunities posed by aging populations in an era of increasing longevity. Many countries around the world today are experiencing the rapid growth of aging populations, with a decline in fertility rate and longer life expectancy. At this year's Annual Meeting of the World Economic Forum (a.k.a. Davos Forum) on January 20-23, 2016 in Davos-Klosters, Switzerland, four researchers in the field of biological sciences and biotechnology at the Korea Advanced Institute of Science and Technology (KAIST) will discuss the implications of an aging population and explore possible solutions to provide better health care services to the elderly. KAIST will host an IdeasLab twice on the theme "Biotechnology Solutions for Ageing Populations" on January 21st and 23rd, respectively. Professor Byung-Kwan Cho of the Biological Sciences Department will give a presentation on "Rejuvenation via the Microbiome," explaining how microorganisms in the human gut play an important role in preventing aging, or even rejuvenating it. Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department will talk about "Traditional Medicine Reimagined through Modern Systems Biology." Professor Lee will introduce his research results published in Nature Biotechnology (March 6, 2015) and some more new results. He discovered the mechanisms of traditional oriental medicine's (TOM) efficacy by applying systems biology to study structural similarities between natural and nontoxic multi-compounds in the medicine and human metabolites. He will discuss TOM's multi-target approach, which is based on the synergistic combinations of multi-compounds to treat symptoms of a disease, can contribute to the development of new drugs, cosmetics, and nutrients. Professor Youn-Kyung Lim of the Industrial Design Department will speak about a mobile and the Internet of Things-based health care service called "Dr. M" in her presentation on "Advanced Mobile Healthcare Systems." Professor Daesoo Kim of the Biological Sciences Department will share his research on human's happiness and greed in the context of nueroscience and behavioral and biological sciences in a talk entitled "A Neural Switch for Being Happy with Less on a Crowded Planet." KAIST has hosted IdeasLabs several times at the Summer Davos Forum in China, but this is the first time it will participate in the Davos Forum in January. Professor Lee said, "Just like climate change, the issue of how to address aging populations has become a major global issue. We will share some exciting research results and hope to have in depth discussion on this issue with the leaders attending the Davos Forum. KAIST will engage actively in finding solutions that benefit not only Korea but also the international community."
2016.01.19
View 11231
Prof. Jae-Kyu Lee Campaigns on "Bright Internet" Worldwide
Professor Jae-Kyu Lee (pictured on the right) from the College of Business at KAIST is one step closer to fulfilling his dream of achieving the “Bright Internet,” a campaign that he first proposed as he became the president of the Association for Information Systems (AIS) in June 2015. On December 12, 2015, Professor Lee signed a memorandum of understanding (MOU) at a convention center in Fort Worth, Texas, between the AIS and the International Telecommunication Union (ITU)—a specialized agency of the United Nations that is responsible for issues related to information and communication technologies—on a collaborative research and development program to make the Internet safer for everyone. The MOU pursues building a trusted international information and communication technology (ICT) infrastructure by proposing telecommunication policies, developing international standards, and organizing interdisciplinary conferences. The Bright Internet is an initiative to protect online users from cyber terrors, privacy breaches, and cyber-crimes. Further, it involves putting accountability to those who initiate or deliver cyber threats, thereby eliminating the possible source of Internet related crimes. Following the MOU agreement, Prof. Lee delivered a speech on his campaign at the 2015 International Conference on Information Systems and received positive responses from the audience. The Bright Internet campaign has been selected as visions of various ICT organizations worldwide including the Korea Society of Management Information System and the International Federation of Information Processing. KAIST and Tsinghua University in China adopted it as an academic topic for research and teaching. Prof. Lee claimed that the Internet should be used in a manner based on the values of trust, ethics, and decorum. He further noted that it is important to build Internet environments that not only protect individuals from cyber threats or attacks, but also hold those who commit online crimes accountable for their actions.
2015.12.28
View 9174
KAIST and the University of Minnesota-Twin Cities Partner for Research and Education Collaboration
President Steve Kang of KAIST and President Eric W. Kaler of the University of Minnesota-Twin Cities (United States) signed a memorandum of understanding to create exchange programs for students and faculty and to conduct joint research in the field of health and food. The following is an excerpt from President Kaler’s blog (https://storify.com/UMNstory/globalumn-hksk#edaadf) on his visit of KAIST on November 18, 2015: A visit to the Korea Advanced Institute of Science and Technology About 90 miles from Seoul—and more than that two-and-a-half-hours of a bus ride through the rugged early-morning traffic of South Korea’s capital city—sits Daejeon, Korea’s sixth largest city and home to KAIST, the Korea Advanced Institute of Science and Technology. Today, President Kaler and the small University of Minnesota delegation accompanying him visited what’s considered Korea’s MIT, a place focused on research and known to push the limits toward the future. Fingernail heart monitors? Wireless anesthetic-monitoring devices? KAIST is working on them. The overlap of interests—from biomedical engineering to nanotechnology to robotics—between KAIST (pronounced “Kyst”) and the U are remarkable. Smartphone apps to monitor human health and GPS-driven robots to serve military interests or deliver packages were among the developing inventions that KAIST scientists showed to Kaler. And even the personal relationships seem to illustrate the cliché of a small world and the natural affinity of Minnesota and KAIST. KAIST’s President Sang Mo Kang was once the head of the University of Illinois’ department of electrical and computer engineering, and he and Kaler—a renowned chemical engineer before becoming the U’s president—hit it off … despite disagreeing about the potential outcome of Saturday’s Illinois-Gophers football game. Accompanying Kaler on the day’s journey, meetings, and signing of a Memorandum of Understanding between the two schools to advance collaborations was U Associate Professor Sang Hyun Oh. Oh happens to be a physics graduate of this very KAIST and is now a rising star in Minnesota’s Department of Electrical and Computer Engineering. The two sides agreed to focus on matching scholars on their respective campuses to discuss the sorts of research the two institutions can partner on. The idea of “Grand Challenges,” at the core of the U’s Twin Cities campus Strategic Plan, has fascinated Korean higher education leaders during Kaler’s weeklong visit, and KAIST’s leadership was interested in the health and food research, two U strengths. ###
2015.12.04
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KAIST Holds Its Fourth Public Art Exhibition
KAIST hosted an opening ceremony for the annual art exhibition on December 3, 2015 at the KAIST Institute building. The KAIST Art and Design Committee first organized the event in 2012 to promote the integration of art and technology. This year’s event entitled “Understanding the Purpose of an Object” will display 20 art pieces under six themes. Artist Keumhong Lee, Haeyool Roh, Joon Kim, Kyung Lee, and Juhae Yang participated in the exhibition. The names of some of the art pieces include “Feedback Field” by Joon Kim, “Self Action” by Haeyool Roh, and “Net of Time” by Juhae Yang. Juhae Yang believes that, in the digital age, an identity of an object is defined by the traces of light which we read in the information hidden in the barcodes. Based on this interpretation, she transforms the black bars and white spaces into a harmony of colors and sounds. The continuum of colors and sounds in her work arouses time-space synesthesia. Professor Sangmin Bae of the Industrial Design Department, the Director of the KAIST Art and Design Committee, hopes that the exhibition will inspire novel scientific ideas and artistic spirits. The exhibition will remain open to the public until December 20, 2015.
2015.12.03
View 8512
Dr. Ryu of KAIST Receives the S-Oil Outstanding Paper Award
Dr. Je-Kyung Ryu of KAIST’s Department of Physics has been awarded the S-Oil Outstanding Paper Award for his doctoral dissertation’s originality and applicability. Professor Tae-Young Yoon of Physics is his doctoral advisor. The award ceremony took place on November 25, 2015 at the Press Center in Seoul. This S-Oil Outstanding Paper Award, jointly sponsored by the Korean Academy of Science and Technology (KAST) and the Scholastic University Presidential Association, was established to foster young talented scientists in basic science and to advance the field. The award is given every other year for each of the fields of physics, chemistry, mathematics, biology, and earth sciences. With the award, Dr. Ryu received a research grant of USD 8,600. He discovered, for the first time in the world, how NSF (N-ethylmaleimide-sensitive factor), a protein involved in a vesicular transport in cellular activities, disassembles a SNARE (soluble NSF attachment protein receptor) complex, using a unimolecular biophysics method. Unlike the existing studies, he proposed a model in which NSF disassembles SNARE complexes at one step, and as a result, provided evidence of how the SNARE complex influenced the fusion of biological membranes. His research was published in the scientific journal Science issued on March 27, 2015. The title of the paper is “Spring-loaded Unraveling of a Single SNARE Complex by NSF in One Round of ATP Turnover.”
2015.11.27
View 9191
KAIST and Four Science and Technology Universities Host a Start-up Competition
KAIST and four other science and technology universities, such as Gwangju Institute of Science and Technology (GIST), Ulsan National Institute of Science and Technology (UNIST), Daegu Gyeongbuk Institute of Science and Technology (DGIST), and Pohang University of Science and Technology (POSTECH), hosted a startup competition on November 27, 2015 at the Dongdaemun Design Plaza in Seoul. Approximately 150 participants including students from the five universities, "angel" investors, and entrepreneurs attended the competition. The competition was held to promote startups that are based on research achievements in science and technology and to foster entrepreneurs with great potential. Two hundred and sixty applicants from 81 teams competed this year. Only ten teams made it to the finals. KAIST students presented two business plans: an experience-centered education platform and mobile taxi-pooling service. Students from other universities presented a brain-stimulating simulation software (GIST), handy smart health trainer (GIST), real-time reporting system for luggage (DGIST), a flower delivery system (UNIST), surveillance and alarm system for stock-related events via machinery studies (UNIST), augmented emotion toys using augmented reality (POSTECH), and a nasal spray for fine dust prevention (POSTECH). KAIST also displayed an exhibition of “wearable haptic device for multimedia contents” and “next generation recommendation service platform based on one-on-one matching system with high expandability and improved user experience system.” The winning team received an award from the Minister of Science, ICT and Future Planning of Korea, as well as an opportunity to participate in overseas startup programs over the course of ten days. Joongmyeon Bae, Director of the KAIST Industry and University Cooperation, who organized the contest, said, “The alumni of Stanford University (USA) has annually created over 5.4 million jobs through startup activities. Likewise, we hope that our event will contribute to job creation by fostering innovative entrepreneurs.”
2015.11.26
View 10981
Professor Keon-Jae Lee Lectures at IEDM and ISSCC Forums
Professor Keon-Jae Lee of KAIST’s Materials Science and Engineering Department delivered a speech at the 2015 Institute of Electrical and Electronics Engineers (IEEE) International Electron Devices Meeting (IEDM) held on December 7-9, 2015 in Washington, D.C. He will also present a speech at the 2016 International Solid-State Circuits Conference scheduled on January 31-February 4, 2016 in San Francisco, California. Both professional gatherings are considered the world’s most renowned forums in electronic devices and semiconductor technology. It is rare for a Korean researcher to be invited to speak at these global conferences. Professor Lee was recognized for his research on flexible NAND chips. The Korea Times, an English language daily newspaper in Korea, reported on his participation in the forums and his recent work. An excerpt of the article follows below: “KAIST Professor to Lecture at Renowned Tech Forums” By Lee Min-hyung, The Korea Times, November 26, 2015 Recently he has focused on delivering technologies for producing flexible materials that can be applied to everyday life. The flexible NAND flash memory chips are expected to be widely used for developing flexible handsets. His latest research also includes flexible light-emitting diodes (LED) for implantable biomedical applications. Lee is currently running a special laboratory focused on developing new flexible nano-materials. The research group is working to develop what it calls “self-powered flexible electronic systems” using nanomaterials and electronic technology. Lee’s achievement with flexible NAND chips was published in the October edition of Nano Letters, the renowned U.S.-based scientific journal. He said that flexible memory chips will be used to develop wearable computers that can be installed anywhere.
2015.11.26
View 11178
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