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Artificial Antibody-based Therapeutic Candidate for Lung Cancer Developed
Professor Hak-Sung Kim of Biological Sciences at KAIST publishes a cover article on artificial antibody in "Molecular Therapy".
Repebody-based lung cancer therapeutic drug candidate developed Repebody-based protein demonstrates the possibility of the development of a new drug
KAIST Biological Sciences Department’s Professor Hak-Sung Kim, in collaboration with Professor Eun-Kyung Cho from the College of Medicine at Chungnam National University, has successfully developed an artificial antibody-based, or repebody, cancer therapeutic candidate. These research results were published as a cover paper of the July edition of Molecular Therapy.
The repebody developed by Professor Kim and his team strongly binds to interleukin-6, a cancer-causing factor. It has also been confirmed that the repebody can significantly inhibit the proliferation of cancer cells in non-small-cell lung cancer animal model.
Numerous multinational pharmaceutical and biotechnology companies have invested astronomical amounts of money in research for the development of protein therapeutics with low side effects and high efficacy. More than 20 kinds of such therapeutics are currently under clinical trials, and over 100 drugs are under clinical demonstration. Among these, the majority is antibody-based therapeutics, and most of the investments are heavily concentrated in this field. However, antibody production cost is very high because it has large molecular weights and complex structural properties, and this makes it difficult to engineer. Consequently, the development costs a great deal of time and money.
In order to overcome the existing limitations of antibody-based therapeutics, Professor Kim and his team have developed a new artificial antibody, or repebody, which was published in Proceedings of the National Academy of Sciences (PNAS) in 2012. Based on this research, they have succeeded in developing a therapeutic candidate for treating non-small-cell lung cancer with a specifically strong cohesion to the cancer-causing factor, interleukin-6.
Interleukin-6 is a crucial substance within the body that is involved in immune and inflammatory-related signals. When abnormally expressed, it activates various carcinogenic pathways and promotes tumor growth and metastasis. Because of its importance, multinational pharmaceutical companies are heavily investing in developing therapeutics that can inhibit the signaling of interleukin-6.
In this study, Professor Kim and his team observed that a repebody consists of repeated modules, and they conceived a module-based affinity amplification technology that can effectively increase the binding affinity with the disease target. The developed therapeutic candidate has been confirmed in cell and animal experiments to show low immunogenicity, as well as to strongly inhibit the proliferation of non-small-cell lung cancer.
Furthermore, by investigating the complex structure of the repebody with interleukin-6, Professor Kim has identified its mechanism, which demonstrated the potential for therapeutic development. The researchers are currently carrying out pre-clinical trials for acquiring permission to perform clinical trials on animals with non-small-cell lung cancer. The repebody can be developed into a new protein drug after demonstrating its safety and efficacy.
Professor Hak-Sung Kim and his team have confirmed that the repebody can be utilized as a new protein drug, and this will be a significant contribution to Korea’s protein drugs and biotechnology industry development.
The research was supported by the Future Pioneer Industry project and sponsored by the Ministry of Science, ICT and Future Planning.
Figure 1. Professor Kim’s article published as the cover article of July edition of Molecular Therapy
Figure 2. Clinical proof of the repebody’s inhibition of cancer growth using animal models
2014.07.14 View 14329 -
Professor Haeng-Ki Lee appointed as "ICCES Distinguished Fellow"
Professor Haeng-Ki Lee
Professor Haeng-Ki Lee from the Department of Civil and Environmental Engineering at KAIST has been appointed as “Distinguished Fellow” and has also received the “Outstanding Research Award” at the International Conference on Computational & Experimental Engineering and Sciences (ICCES).
Founded in 1986, ICCES is regarded as one of the most prestigious international conferences in the field of computational mechanics and experimental engineering.
The Nominating Committee at ICCES recommends the appointment of a distinguished member who has made significant contributions to the development of computational mechanics and experimental engineering. Professor Lee was the first Korean who received such title. Furthermore, he was the recipient of the “Outstanding Research Award” presented by ICCES for his academic research on damage mechanics of complex systems.
Professor Lee is currently serving as the Head of the Department of Civil and Environmental Engineering at KAIST and the Director of BK Plus Agency, a Korean government’s research program. He received an award from the Minister of Science, ICT and Future Planning in 2013 for the promotion of science and technology.
2014.07.02 View 13053 -
KAIST doctoral student wins prize at 2014 International Military Science and Technology Fair
Min-Kyu Yoo (far left), a doctoral student in the Department of Materials Science Engineering, KAIST, received a silver prize at the 2014 International Military Science and Technology Fair held from May 29 to June 1, 2014 at KINTEX, Ilsan City, Korea.
Yoo presented a paper on aluminum composite materials that were reinforced by carbon nanotubes. Carbon nanotubes reinforced aluminum composite materials have strong mechanical properties, and some nations have used them to manufacture battle tanks.
Aluminum generates hydrogen in an alkaline solution. Utilizing this property and the galvanic corrosion of carbon nanotubes and aluminums, Yoo developed a hydrogen energy system that is fueled with composite materials of carbon nanotube reinforced aluminum. He produced 5 kW electric power and maintained it 22 days using 10 kg of the composite materials for a proton exchange membrane fuel cell and its auxiliary power system.
Yoo’s research will alleviate the difficulty of transporting fuels during wartime and can be applied to the development of an auxiliary power system for next generation aircrafts and battle tanks.
2014.06.24 View 10271 -
Professor Sung Yong Kim Appointed as Committee Member to Serve PICES
The Pacific International Council for the Exploration of the Sea: North Pacific Marine Science Organization (PICES) is an intergovernmental organization, which was established in 1992 to promote and coordinate marine research in the North Pacific and adjacent areas. Currently, the United States, Canada, Japan, China, Russia, and Korea are members of the organization.
Professor Sung Yong Kim of Ocean Systems Engineering, KAIST, has been appointed to serve the Scientific and Technical Committees of PICES. He will begin his stint from July 1, 2014. During his assignment, Professor Kim will identify the need for observation of the North Pacific marine environment, develop observation methodology, and publish an annual report on the observation.
Professor Kim is an expert in marine physics and environmental fluids, with a focus on coastal circulation and dynamics, mesoscale and submesoscale eddies, integrated coastal ocean observing system, and statistical and dynamic data analysis.
2014.06.18 View 10091 -
Immune Evasion Mechanism of Hepatitis C Virus Revealed
Professor Ui-Cheol Shin
Inhibiting major histocompatibility complex [MHC] class I protein expression, T cell immune response is evaded.
The research will be a great help to the development of C hepatitis vaccine.
Roughly 1-2% of the population in Korea is known to be infected with Hepatitis C. Most Hepatitis C Virus (HCV) infections progress to a chronic disease and can cause liver cirrhosis or liver cancer, which may lead to death.
Unlike Hepatitis type A or B, there is no vaccine for Hepatitis C Virus and therefore avoiding exposure to the virus is the best known method of prevention. However, a team of researchers at KAIST has produced research results, which may contribute significantly to the vaccine development.
KAIST Graduate School of Medical Sciences & Engineering’ Professor Ui-Cheol Shin and his team have successfully identified why Hepatitis C Virus does not cause an immune response within the human body. The research results were published in the May edition of The Journal of Gastroenterology, a world-renowned journal in the field of gastroenterology.
The immune response occurs to eliminate the virus that has invaded our body. During this process, a major histocompatibility complex [MHC] class I plays a key role in inducing T cell response, which is needed for the elimination of virus-infected cells.
When a cell is infected by a virus, a substance called interferon causes the increased expression of major histocompatibility complex class I. T cell recognizes the increased MHC class I and therefore finds the virus-infected cells.
However, the effect that Hepatitis C Virus has on major histocompatibility complex class I has not been clearly identified until now.
The research team has revealed, using a cell culture for infection systems, that the Hepatitis C Virus suppresses the expression of major histocompatibility complex class I. Also, the mechanism to prove that HCV activates a protein called PKR within the cell to inhibit MHC class I protein expression was identified at a molecular level.
In this study, researchers established the hypothesis that regulating PKR protein in the cell can enhance the T cell immune response, which was then proved through experiments.
Professor Ui-Cheol Shin said, “There are a lot of new drugs to treat Hepatitis C Virus, while its vaccine has not been developed yet. Revealing the HCV immune evasion mechanism will help stimulate momentum for the HCV vaccine development.”
The first author of the journal, Dr. Won-Seok Kang is a graduate from Yonsei College of Medicine. After earning his medical degree, he has continued his training as a ‘doctor-scientist’ at KAIST Graduate School of Medical Sciences & Engineering to study Hepatitis C Virus immune evasion mechanism in this research.
Hepatitis C Virus activates PKR-eIF2a pathway, which inhibits the major histocompatibility complex class I, and therefore weakens the T cell activation to the viral activity.
2014.05.19 View 11851 -
SPIE (The International Society for Optics and Photonics): Scattering Super-lens
The International Society for Optics and Photonics (SPIE), dedicated to advancing an interdisciplinary approach to the science and application of light, published online a short paper authored by a KAIST research team, Dr. Jung-Hoon Park and Professor YongKeun Park of Physics, introducing a new optical technology to observe sub-wavelength light by exploiting multiple light scattering in complex media.
For the article, please go to the link below:
SPIE: Nanotechnology
May 7th, 2014
"Scattering superlens" by Jung-Hoon Park and YongKeun Park
http://spie.org/x108298.xml
2014.05.14 View 8246 -
Press release from the Association to Advance Collegiate Schools of Business (AACSB International): Eighty-five business schools extend their AACSB accreditation in business or accounting
The Association to Advance Collegiate Schools of Business (AACSB International) released a news announcement on April 1, 2014, saying that 85 business schools around the world extended their AACSB accreditation in business or accounting. KAIST is one of the 85 schools which is renewing its business accreditation for another five years.
Founded in 1916, AACSB International is a global accrediting organization for business schools that offer undergraduate, master’s, and doctorate degrees in business and accounting. The release said, “AACSB Accreditation is the hallmark of excellence in business education and has been earned by less than five percent of the world’s business schools. Today, there are 694 business schools in 45 countries and territories that have earned the accreditation.”
For the entirety of the release, please go to:
http://www.aacsb.edu/en/newsroom/2014/4/eighty-five-b-schools-extend-accreditation/
2014.04.02 View 7287 -
Professor Huen Lee to Receive Lifetime Achievement Award from the International Conference on Gas Hydrates
Professor Huen Lee of the Chemical and
Biomolecular Engineering Department at KAIST will receive a lifetime
achievement award at the 8th International Conference on Gas
Hydrates (ICGH) to be held from July 28, 2014 to August 2, 2014 in Beijing,
China.
Among his other scholarly and research accomplishments, Professor Lee achieved the development of natural gas by injecting
carbon dioxide and nitrogen into the layers of gas hydrates. With this
technology, ConocoPhilips, an American multinational energy corporation,
successfully extracted natural gas from the gas hydrates in the North Slope of
Alaska in the US in April 2012.
Meeting every three years in a different
country around the world, ICGH is a leading gathering of scientists and
engineers in gas hydrates. The 8th conference will be held under the
theme of “Opportunity and Challenge-Development and Utilization of Gas
Hydrates.”
2014.03.25 View 8872 -
KAIST Holds the 2014 System on Chip (SoC) Robot War in August and October
Domestic and international competitions for robots with artificial intelligence are organized by Professor Hoi-Jun Yoo of Electrical Engineering.
KAIST will host two robot competitions this year: The Robot Integration Festival will be held in August at the Convention Center in Daejeon and the International Robot Contest in October at the Kintex in Ilsan. Participating robots are developed based on the System on Chip (SoC).
SoC robots refer to an autonomous robot that has a processor, a memory, peripheral devices, logic, and other system components combined on a single chip, which enables the robots to handle tasks and make decisions without human intervention.
The competitions include three entries: Taekwon Robot, HURO-competition, and SoC Drone which was added for the first time this year.
The Taekwon Robot involves a one-on-one sparring match, using a Korean traditional martial art, between two robots. Competitors score points based on front and side kicks, as well as punching. The HURO-competition pits robots in a competition to perform assignments such as hurdling, barricade clearing, crossing bridges, and overcoming other obstacles. The SoC Drone evaluates robots' capability to track miniature cars and navigate between buildings while in flight. The drone should have two cameras and a SoC brainboard equipped to offer autonomous, remote-controlled flight.
The director of the competitions, Professor Hoi-Jun Yoo of Electrical Engineering at KAIST, commented that with the integration of Korea’s world-class semiconductor technology, the competitions would lead to improvements in robotics engineering and unmanned aerial vehicle technology.
The competitions are open to anyone interested in SoC robots and unmanned aerial vehicles. For more information about the competitions, please visit http://www.socrobotwar.org . The application deadline is April 15, 2014.
2014.03.11 View 11757 -
K-Glass: Korea's Answer to Google Glass
Wall Street Journal (blog) published an
article on the K-Glass developed by Professor Hoi-Jun Yoo of Electrical
Engineering at KAIST. For the article, please go to the link below:
K-Glass: Korea’s Answer to Google Glass, March 5, 2014
http://blogs.wsj.com/digits/2014/03/05/meet-k-glass-koreas-answer-to-google-glass/
2014.03.07 View 8605 -
Seung-Han Lee, a doctoral student in electrical engineering, receives the best paper award from ISQED 2014
Seung-Han
Lee, a doctoral candidate in the department of electrical engineering at KAIST,
received a Best Paper Award from the International Symposium on Quality
Electronic Design (ISQED), a high-profile international conference started in 2000 to promote innovation and quality in electronic and
engineering designs through inter- and multidisciplinary approaches. The
award ceremony will take place at the 2014 ISQED on March 3-5, 2014 at the Convention
Center in Santa Clara, CA, USA.
Professor
Chong-Min Kyung, an advisor to Seung-Han, expressed his excitement about his student's achievement.
“This is
the first time a Korean has ever received the best paper award at this academic
conference. It’s great news to our student as well as to KAIST.”
The topic
of Lee’s research paper was dynamic cache data management for minimizing the
energy consumption of three-dimensional multi-processor semiconductor chips.
2014.03.03 View 12124 -
Professor Yong-Tak Im of Mechanical Engineering Appointed as President of Korea Institute of Machinery and Materials
Yong-Tak Im, Professor of the Department of
Mechanical Engineering at KAIST, was sworn in on February 25, 2014 as
the 16th president of the Korea Institute of Machinery and Materials
(KIMM), a leading government-funded research institution in Korea. KIMM was
established in 1976 to contribute to the development of
Korea through the invention of source technology and technology transfer in
mechanical engineering.
President Im graduated from Seoul National
University, obtaining degrees of Bachelor of Science and Master’s in mechanical
engineering. He later studied at the University of California in Berkeley and
received a doctoral degree in mechanical engineering.
After working as an assistant professor of
the Industrial and Systems Engineering at the Ohio State University,
President Im joined KAIST as a professor of mechanical engineering in 1989.
President Im took many important posts at
KAIST, including Dean of Planning Office, Dean of External Affairs and Public
Relations Office, and Associate Vice President of Special Projects and
Institutional Relations, making a great addition to the university’s endeavors for
globalization.
Among the awards President Im received was the
William Johnson Award in 2007 presented by the Advances in Materials and
Processing Technologies, the Research Achievement Award in 2010 by the Global
Congress on Manufacturing and Management, and the Presidential Award in 2012 by
the Republic of Korea. He was also elected as the vice president of the Korean
Society of Mechanical Engineers, the largest association of professionals in
the mechanical engineering field in Korea.
President Im is currently a professor at
POSCO, an internationally known Korean steel company, and a member of the
Korean Academy of Science and Technology and the National Academy of
Engineering of Korea, respectively.
President Im will serve KIMM for three
years until February 24, 2017.
2014.02.25 View 12483