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Professor Won Do Heo on LED Light Technology for Controlling Proteins in Living Cells
With the newly developed LED technology, Professor Won Do Heo at the College of Life Science and Bioengineering, KAIST, was able to suppress cell migration and division when cells are exposed to LED light. This suggests a breakthrough to apply in future cancer cell research. Professor Heo talked about the impact of his research in the following excerpt from a news article: “We are already conducting research on the spread of cancer, as well as brain science in animal models with the Light-Activated Reversible Inhibition by Assembled Trap. I believe this technology will be a breakthrough in investigating cancer treatments and the function of neurons in a complex neural network, which existing technologies have not been able to do.” From EE Times Europe, June 19, 2014 “LED Light Technology Controls Proteins in Living Cells” http://www.ledlighting-eetimes.com/en/led-light-technology-controls-proteins-in-living-cells.html?cmp_id=7&news_id=222909336
2014.06.22
View 6984
Professor Sang-Ouk Kim's Research on Carbon Materials Featured in a Philippines Science News
The subject article said that Professor Sang-Ouk Kim of Materials Science Engineering at KAIST “developed a technique to change the nature of the next-generation carbon-based materials. His research has expanded the possibility of carbon-based materials to be used in clothes.” For details, please refer to the article below: Centrio Times, June 10, 2014 KAIST scientist develops color changing carbon materials that can be used in clothes http://www.centriotimes.com/2014/06/kaist-scientist-develops-color-changing-carbon-materials-can-used-clothes.html.
2014.06.15
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KAIST ranked third in the top 100 universities under 50 years old
The Times Higher Education (THE) released on April 30, 2014 its annual ranking of 100 top universities whose history is under 50 years. KAIST placed 3rd, holding the same spot from last year. The (THE) 100 Under 50 ranking used 13 indicators across five factors to measure the performance of institutions: research, citations, teaching, international outlook, and industry income. The indicators included research volume and income, reputation, learning environment, staff-to-student ratio, scholarly papers produced, and the percentage of international staff as part of the institution’s faculty. Phil Baty, editor of the Times ranking, compared younger and older universities as follows: “Young universities are free to be more agile, lean, and risk-taking, giving them an advantage in a rapidly changing global marketplace. They are also free to offer innovative teaching and focus their research in niche, high-impact areas.” KAIST and Pohang University of Science and Technology (ranked first) are the only Korean universities that made the ranking list. For the full list, please go to: http://www.timeshighereducation.co.uk/world-university-rankings/2014/one-hundred-under-fifty This information was provided by the Times Higher Education 100 Under 50.
2014.05.03
View 10017
Times Higher Education 2014 World Reputation Rankings
Times Higher Education released the 2014 World Reputation Rankings on March 6, 2014. KAIST moved from the 61-70 band in 2013 to the 51-60 place this year. For details, please visit the link below: http://www.scoop.co.nz/stories/WO1403/S00091/times-higher-education-2014-world-reputation-rankings.htm
2014.03.07
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Seung-Han Lee, a doctoral student in electrical engineering, receives the best paper award from ISQED 2014
Seung-Han Lee, a doctoral candidate in the department of electrical engineering at KAIST, received a Best Paper Award from the International Symposium on Quality Electronic Design (ISQED), a high-profile international conference started in 2000 to promote innovation and quality in electronic and engineering designs through inter- and multidisciplinary approaches. The award ceremony will take place at the 2014 ISQED on March 3-5, 2014 at the Convention Center in Santa Clara, CA, USA. Professor Chong-Min Kyung, an advisor to Seung-Han, expressed his excitement about his student's achievement. “This is the first time a Korean has ever received the best paper award at this academic conference. It’s great news to our student as well as to KAIST.” The topic of Lee’s research paper was dynamic cache data management for minimizing the energy consumption of three-dimensional multi-processor semiconductor chips.
2014.03.03
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World's Largest Web Conference To Be Held in Korea
The 2014 International World Wide Web Conference (WWW 2014), the world’s most prestigious academic conference in the field of web, will be held for the first time in Korea. The conference is to be last for five days at Seoul COEX, from 7th to 11th April. International World Wide Web Conference covers a wide range of web-related areas, including technologies, research papers, services and more. Since the first conference in 1994 in Switzerland, it has been held in various parts of North America, Europe, South America and Asia, attracting more than 1000 experts in the field. The 23rd International World Wide Web Conference is managed by the International World Wide Web Conferences Steering Committee (IW3C2) and co-hosted by KAIST and National Agency for Technology and Standards, as well as sponsored by Korea Information Science Society and the World Wide Web Consortium (W3C). Keynote speakers for this year’s conference include inventor of the World Wide Web, Sir Tim Berners-Lee, senior vice president of Microsoft, Dr. Qi Lu, and Carnegie Mellon University’s Prof. Christos Faloutsos, as well as Samsung Electronic’s vice president Jong-Deok Choi. In addition to WWW 2014, BigData Innovators Gathering (BIG 2014) and Web for Access (W4A 2014) is also to be held in joint. KAIST Computer Sciences Department’s Prof. Jinwan Jeong, in charge of directing this year’s conference, said “From one-sided 1st generation web to two-way 2nd generation web, such as blogs, and then recently to the 3rd generation web, which include social networks and semantic webs, the web technologies has grown vastly over the past 25 years. WWW 2014 will be the opportunity for Korea to discuss with the world about the informatization and future of the web.” Pre-registration for WWW 2014 can be applied at the official webpage for WWW 2014 (http://www2014.kr) before 17th February.
2014.02.14
View 8058
KAIST announced a novel technology to produce gasoline by a metabolically engineered microorganism
A major scientific breakthrough in the development of renewable energy sources and other important chemicals; The research team succeeded in producing 580 mg of gasoline per liter of cultured broth by converting in vivo generated fatty acids For many decades, we have been relying on fossil resources to produce liquid fuels such as gasoline, diesel, and many industrial and consumer chemicals for daily use. However, increasing strains on natural resources as well as environmental issues including global warming have triggered a strong interest in developing sustainable ways to obtain fuels and chemicals. Gasoline, the petroleum-derived product that is most widely used as a fuel for transportation, is a mixture of hydrocarbons, additives, and blending agents. The hydrocarbons, called alkanes, consist only of carbon and hydrogen atoms. Gasoline has a combination of straight-chain and branched-chain alkanes (hydrocarbons) consisted of 4-12 carbon atoms linked by direct carbon-carbon bonds. Previously, through metabolic engineering of Escherichia coli (E. coli), there have been a few research results on the production of long-chain alkanes, which consist of 13-17 carbon atoms, suitable for replacing diesel. However, there has been no report on the microbial production of short-chain alkanes, a possible substitute for gasoline. In the paper (entitled "Microbial Production of Short-chain Alkanes") published online in Nature on September 29, a Korean research team led by Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering at the Korea Advanced Institute of Science and Technology (KAIST) reported, for the first time, the development of a novel strategy for microbial gasoline production through metabolic engineering of E. coli. The research team engineered the fatty acid metabolism to provide the fatty acid derivatives that are shorter than normal intracellular fatty acid metabolites, and introduced a novel synthetic pathway for the biosynthesis of short-chain alkanes. This allowed the development of platform E. coli strain capable of producing gasoline for the first time. Furthermore, this platform strain, if desired, can be modified to produce other products such as short-chain fatty esters and short-chain fatty alcohols. In this paper, the Korean researchers described detailed strategies for 1) screening of enzymes associated with the production of fatty acids, 2) engineering of enzymes and fatty acid biosynthetic pathways to concentrate carbon flux towards the short-chain fatty acid production, and 3) converting short-chain fatty acids to their corresponding alkanes (gasoline) by introducing a novel synthetic pathway and optimization of culture conditions. Furthermore, the research team showed the possibility of producing fatty esters and alcohols by introducing responsible enzymes into the same platform strain. Professor Sang Yup Lee said, "It is only the beginning of the work towards sustainable production of gasoline. The titer is rather low due to the low metabolic flux towards the formation of short-chain fatty acids and their derivatives. We are currently working on increasing the titer, yield and productivity of bio-gasoline. Nonetheless, we are pleased to report, for the first time, the production of gasoline through the metabolic engineering of E. coli, which we hope will serve as a basis for the metabolic engineering of microorganisms to produce fuels and chemicals from renewable resources." This research was supported by the Advanced Biomass Research and Development Center of Korea (ABC-2010-0029799) through the Global Frontier Research Program of the Ministry of Science, ICT and Future Planning (MSIP) through the National Research Foundation (NRF), Republic of Korea. Systems metabolic engineering work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries (NRF-2012-C1AAA001-2012M1A2A2026556) by MSIP through NRF. Short-Chain Alkanes Generated from Renewable Biomass This diagram shows the metabolic engineering of Escherichia coli for the production of short-chain alkanes (gasoline) from renewable biomass. Nature Cover Page (September 29th, 2013)
2013.11.04
View 9458
Artist in residence program at KAIST
A new and innovative program to support artists’ creative activities was launched by KAIST for the first time in Korean college history. The artist in residence program is an unusual collaboration between engineers and artists. Out of hundreds of applicants for the program, three writers were selected: a novelist, web-based cartoonist, and screen writer. In late October, they became the residents of KAIST. Housing and an office are provided for the writers in addition to a monthly cash stipend of 800,000 won for up to six months. A variety of programs will be available as well including a tour of laboratories to help the writers get ideas and inspiration. KAIST’s Vice President Jun-Ho Oh, the founder of the program, said, “Artists can freshen their imagination, and KAIST members can benefit from them to promote creative and innovative ideas through exchange and collaboration.”
2013.11.04
View 5682
KAIST Placed 3rd in the World's Best 100 Emerging Universities
The Times Higher Education (THE) published its world university rankings on June 20, 2013. It is a list of the best 100 universities whose histories are 50 years old or younger. KAIST was ranked 3rd in the list, two places up from the 5th last year. Forbes and Reuters carried a story on the top ten emerging universities out of the listed 100 institutions, highlighting strong showings in the Asian region. For the articles, please see the attached file (Forbes) or click the link (Reuters) below: http://www.reuters.com/article/2013/06/19/education-university-rankings-idUSL2N0EU1HZ20130619
2013.06.22
View 6234
The new era of personalized cancer diagnosis and treatment
Professor Tae-Young Yoon - Succeeded in observing carcinogenic protein at the molecular level - “Paved the way to customized cancer treatment through accurate analysis of carcinogenic protein” The joint KAIST research team of Professor Tae Young Yoon of the Department of Physics and Professor Won Do Huh of the Department of Biological Sciences have developed the technology to monitor characteristics of carcinogenic protein in cancer tissue – for the first time in the world. The technology makes it possible to analyse the mechanism of cancer development through a small amount of carcinogenic protein from a cancer patient. Therefore, a personalised approach to diagnosis and treatment using the knowledge of the specific mechanism of cancer development in the patient may be possible in the future. Until recently, modern medicine could only speculate on the cause of cancer through statistics. Although developed countries, such as the United States, are known to use a large sequencing technology that analyses the patient’s DNA, identification of the interactions between proteins responsible for causing cancer remained an unanswered question for a long time in medicine. Firstly, Professor Yoon’s research team has developed a fluorescent microscope that can observe even a single molecule. Then, the “Immunoprecipitation method”, a technology to extract a specific protein exploiting the high affinity between antigens and antibodies was developed. Using this technology and the microscope, “Real-Time Single Molecule co-Immunoprecipitation Method” was created. In this way, the team succeeded in observing the interactions between carcinogenic and other proteins at a molecular level, in real time. To validate the developed technology, the team investigated Ras, a carcinogenic protein; its mutation statistically is known to cause around 30% of cancers. The experimental results confirmed that 30-50% of Ras protein was expressed in mouse tumour and human cancer cells. In normal cells, less than 5% of Ras protein was expressed. Thus, the experiment showed that unusual increase in activation of Ras protein induces cancer. The increase in the ratio of active Ras protein can be inferred from existing research data but the measurement of specific numerical data has never been done before. The team suggested a new molecular level diagnosis technique of identifying the progress of cancer in patients through measuring the percentage of activated carcinogenic protein in cancer tissue. Professor Yoon Tae-young said, “This newly developed technology does not require a separate procedure of protein expression or refining, hence the existing proteins in real biological tissues or cancer cells can be observed directly.” He also said, “Since carcinogenic protein can be analyzed accurately, it has opened up the path to customized cancer treatment in the future.” “Since the observation is possible on a molecular level, the technology confers the advantage that researchers can carry out various examinations on a small sample of the cancer patient.” He added, “The clinical trial will start in December 2012 and in a few years customized cancer diagnosis and treatment will be possible.” Meanwhile, the research has been published in Nature Communications (February 19). Many researchers from various fields have participated, regardless of the differences in their speciality, and successfully produced interdisciplinary research. Professor Tae Young Yoon of the Department of Physics and Professors Dae Sik Lim and Won Do Huh of Biological Sciences at KAIST, and Professor Chang Bong Hyun of Computational Science of KIAS contributed to developing the technique. Figure 1: Schematic diagram of observed interactions at the molecular level in real time using fluorescent microscope. The carcinogenic protein from a mouse tumour is fixed on the microchip, and its molecular characteristics are observed live. Figure 2: Molecular interaction data using a molecular level fluorescent microscope. A signal in the form of spike is shown when two proteins combine. This is monitored live using an Electron Multiplying Charge Coupled Device (EMCCD). It shows signal results in bright dots. An organism has an immune system as a defence mechanism to foreign intruders. The immune system is activated when unwanted pathogens or foreign protein are in the body. Antibodies form in recognition of the specific antigen to protect itself. Organisms evolved to form antibodies with high specificity to a certain antigen. Antibodies only react to its complementary antigens. The field of molecular biology uses the affinity between antigens and antibodies to extract specific proteins; a technology called immunoprecipitation. Even in a mixture of many proteins, the protein sought can be extracted using antibodies. Thus immunoprecipitation is widely used to detect pathogens or to extract specific proteins. Technology co-IP is a well-known example that uses immunoprecipitation. The research on interactions between proteins uses co-IP in general. The basis of fixing the antigen on the antibody to extract antigen protein is the same as immunoprecipitation. Then, researchers inject and observe its reaction with the partner protein to observe the interactions and precipitate the antibodies. If the reaction occurs, the partner protein will be found with the antibodies in the precipitations. If not, then the partner protein will not be found. This shows that the two proteins interact. However, the traditional co-IP can be used to infer the interactions between the two proteins although the information of the dynamics on how the reaction occurs is lost. To overcome these shortcomings, the Real-Time Single Molecule co-IP Method enables observation on individual protein level in real time. Therefore, the significance of the new technique is in making observation of interactions more direct and quantitative. Additional Figure 1: Comparison between Conventional co-IP and Real-Time Single Molecule co-IP
2013.04.01
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2012 Times Higher Education Ranks KAIST a Record High of 68th
KAIST was evaluated as the 68th best university by the Times Higher Education, a English University Evaluation Body. The 2012 evaluation is 29 places higher than the 2011 evaluation. As a side note, KAIST was ranked a record high of 63rd in the world by Quacquarelli Symonds’ 2012 QS World University Evaluation.
2012.10.16
View 6301
KAIST College of Business ranks no.1 in Asia for executive education
KAIST College of Business ranked 28th in the world and 1st in Asia in the UK Financial Times (FT) 2012 Executive Education open ranking, making it the only school in Korea to be included. The FT ranking selects the world’s top 65 business graduate schools based on executive education course design, teaching methods & materials, faculty, new skills & learning, quality of participants, and several other criteria. Last year, the KAIST executive education program ranked 29th in the world and 2nd in Asia. This year, it surpassed China’s CEIBS to rank 1st in Asia and has now been included in the ranking for three consecutive years. Looking at the individual criteria, KAIST ranked highly in course preparation (11th), international location (11th), facilities (12th), and follow-up (5th) and saw increases in aims achieved (31st) and course design (29th). KAIST attributed its success to the differentiation and specialization of education courses based on position, industry, and enterprise. KAIST College of Business operates an integrative course that fuses business management with science & technology, information media, medicine and innovation. The school runs both a chief and junior executive program to cater to different positional needs and provides specialized lectures that consider a company’s industry and size. The ‘international location’ criteria saw a huge leap from 23rd to 11th due to the use of both long term and short term overseas exchange programs. The ‘Global Leader’ course created in 2011 is taught only in English and allows students to study abroad in a partner school in the second semester. The college’s knowhow in the MBA program also achieved recognition with high rankings in new skills & learning (18th) as well as in teaching methods & materials (24th). College of Business President Lee Byung Tae said that the school’s success was achieved through a specialized curriculum that considers the market and explained that the ranking reflects the school’s competitiveness. He also said that KAIST will continue to provide the best educational services appropriate for KAIST’s outstanding reputation. In the overall ranking, Swiss IMD was ranked number 1, followed by the Harvard Business School. In Asia, China’s CEIBS (29th), Singapore’s Aalto University (42nd), and the National University of Singapore Business School (64th) followed suit.
2012.05.17
View 8150
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