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Renault 5 EV and Canoo’s Pickup Truck Win the 2021 FMOTY Awards
KAIST Future Mobility of the Year Awards recognize the most innovative concept cars of the year The Renault 5 EV from France and a pickup truck from the US startup Canoo won the 2021 Future Mobility of the Year Awards (FMOTY) hosted by the Cho Chun Shik Graduate School of Green Transportation at KAIST. The awards ceremony was held at Renault Samsung Motors in Seoul on November 25. KAIST began the FMOTY in 2019 to advance future car technology and stimulate growth in the industry. The award recognizes the most innovative ideas for making the most futuristic concept car and improving the technological and social value of the industry. The awards ceremony was attended by KAIST President Kwang Hyung Lee, the dean of the Cho Chun Shik Graduate School of Green Transportation In Gwun Jang, CEO of Renault Samsung Motors Dominique Signora, and CEO of Canoo Tony Aquila. President Lee said, “The new world order will be impacted by new technology developers who envision the future. Their innovation and creative ideas will open a new world of sustainable future transportation.” Out of the 46 concept cars revealed at global motor exhibitions between last year and the first quarter of this year, models demonstrating transport technology useful for future society and innovative service were selected in the categories of passenger cars and commercial vehicles. Sixteen automotive journalists from 11 countries, including the chief editor of Car Magazine in Germany Georg Kacher and editorial director of BBC Top Gear Charlie Turner, participated as judges. This year’s award for the best concept car for a passenger vehicle went to an electric vehicle, the Renault 5 EV. The compact electric car was highly regarded for its practicality and environmental friendliness. A pickup truck by Canoo, an American EV manufacturing start-up, won the award in the commercial vehicle category. The pickup features an innovative design allowing for a variety of functions topped with a competitive price and it received overwhelming support from the judges. While Hyundai Motors swept both prizes at the awards last year and demonstrated the potential of Korean concept cars, Canoo’s win in the commercial vehicle section as a young American venture company brought attention to the changing dynamics in the automotive market. This shows that young EV start-ups can compete with existing car companies as the automotive paradigm is shifting from those with internal combustion engines to EVs. The awards organizers said that the Cho Chun Shik Graduate School of Green Transportation will continue to hold the FMOTY to lead the fast-changing global mobility market. For more information, please visit www.fmoty.org.
2021.11.26
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Marien Buissonniere Awarded the 9th Grand Award for Future Strategy
Global healthcare and humanitarian activist honored by the Grand Award for Future Strategy The Moon Soul Graduate School of Future Strategy awarded the 9th Grand Award for Future Strategy to Marine Buissonniere, an independent advisor and practitioner in the fields of global health and humanitarian action. She currently works as a senior advisor to the Prevent Epidemics team at Resolve to Save Lives. She also co-chairs Doctors Without Borders’ Transformational Investment Capacity. Buissonniere was recognized for designing and implementing global response strategies in global strife and disaster stricken areas over the 25 years while serving as secretary general of Doctors Without Borders. She has been working with various government agencies around the world including Resolve to Save Lives to respond to the Covid-19 pandemic and preparing global future strategies for the post-pandemic era. The Grand Award for Future Strategy recognizes individual and organization who have contributed to the nation and humanity through future research and strategies in the fields of science and technology, economy and industry, society and culture, politics and governance, and resources and environment. The selection committee place particular emphasis on her humanitarian efforts toward North Korea. She was in charge of the task force for resuming the health project in North Korea and facilitated the North Korean program in 2002. She also played a significant role in raising awareness of North Korea’s humanitarian issues in the international community by lecturing at Columbia and Princeton. Buissonniere said during the awards ceremony held online on November 5, “I am very grateful to receive this award from KAIST, a world’s top-flight university as well as from South Korea related to the Korean Peninsula and North Korea, where I have spent most of my life. What makes this award even more special is it is about the international medical relief activities and system innovations that I’ve devoted my life to over the last 25 years. I am going to continue this journey to help many people in difficult situations. Eventually, I would like to make it possible for those people in need to make their own future by themselves.”
2021.11.11
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Nanoscale Self-Assembling Salt-Crystal ‘Origami’ Balls Envelop Liquids
Mechanical engineers have devised a ‘crystal capillary origami’ technique where salt crystals spontaneously encapsulate liquid droplets Researchers have developed a technique whereby they can spontaneously encapsulate microscopic droplets of water and oil emulsion in a tiny sphere made of salt crystals—sort of like a minute, self-constructing origami soccer ball filled with liquid. The process, which they are calling ‘crystal capillary origami,’ could be used in a range of fields from more precise drug delivery to nanoscale medical devices.The technique is described in a paper appearing in the journal Nanoscale on September 21. Capillary action, or ‘capillarity,’ will be familiar to most people as the way that water or other liquids can move up narrow tubes or other porous materials seemingly in defiance of gravity (for example within the vascular systems of plants, or even more simply, the drawing up of paint between the hairs of a paintbrush). This effect is due to the forces of cohesion (the tendency of a liquid’s molecules to stick together), which results in surface tension, and adhesion (their tendency to stick to the surface of other substances). The strength of the capillarity depends on the chemistry of the liquid, the chemistry of the porous material, and on the other forces acting on them both. For example, a liquid with lower surface tension than water would not be able to hold up a water strider insect. Less well known is a related phenomenon, elasto-capillarity, that takes advantage of the relationship between capillarity and the elasticity of a very tiny flat sheet of a solid material. In certain circumstances, the capillary forces can overcome the elastic bending resistance of the sheet. This relationship can be exploited to create ‘capillary origami,’ or three-dimensional structures. When a liquid droplet is placed on the flat sheet, the latter can spontaneously encapsulate the former due to surface tension. Capillary origami can take on other forms including wrinkling, buckling, or self-folding into other shapes. The specific geometrical shape that the 3D capillary origami structure ends up taking is determined by both the chemistry of the flat sheet and that of the liquid, and by carefully designing the shape and size of the sheet. There is one big problem with these small devices, however. “These conventional self-assembled origami structures cannot be completely spherical and will always have discontinuous boundaries, or what you might call ‘edges,’ as a result of the original two-dimensional shape of the sheet,” said Kwangseok Park, a lead researcher on the project. He added, “These edges could turn out to be future defects with the potential for failure in the face of increased stress.” Non-spherical particles are also known to be more disadvantageous than spherical particles in terms of cellular uptake. Professor Hyoungsoo Kim from the Department of Mechanical Engineering explained, “This is why researchers have long been on the hunt for substances that could produce a fully spherical capillary origami structure.” The authors of the study have demonstrated such an origami sphere for the first time. They showed how instead of a flat sheet, the growth of salt-crystals can perform capillary origami action in a similar manner. What they call ‘crystal capillary origami’ spontaneously constructs a smooth spherical shell capsule from these same surface tension effects, but now the spontaneous encapsulation of a liquid is determined by the elasto-capillary conditions of growing crystals. Here, the term ‘salt’ refers to a compound of one positively charged ion and another negatively charged. Table salt, or sodium chloride, is just one example of a salt. The researchers used four other salts: calcium propionate, sodium salicylate, calcium nitrate tetrahydrate, and sodium bicarbonate to envelop a water-oil emulsion. Normally, a salt such as sodium chloride has a cubical crystal structure, but these four salts form plate-like structures as crystallites or ‘grains’ (the microscopic shape that forms when a crystal first starts to grow) instead. These plates then self-assemble into perfect spheres. Using scanning electron microscopy and X-ray diffraction analysis, they investigated the mechanism of such formation and concluded that it was ‘Laplace pressure’ that drives the crystallite plates to cover the emulsion surface. Laplace pressure describes the pressure difference between the interior and exterior of a curved surface caused by the surface tension at the interface between the two substances, in this case between the salt water and the oil. The researchers hope that these self-assembling nanostructures can be used for encapsulation applications in a range of sectors, from the food industry and cosmetics to drug delivery and even tiny medical devices. -Publication Kwangseok Park, Hyoungsoo Kim “Crystal capillary origami capsule with self-assembled nanostructure,” Nanoscale, 13(35), 14656-14665 (DOI: 10.1039/d1nr02456f) -Profile Professor Hyoungsoo Kim Fluid and Interface Laboratory http://fil.kaist.ac.kr Department of Mechanical Engineering KAIST
2021.11.04
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GSI Forum Highlights Global Collaboration Toward a Sustainable Global Economy
The forum stresses global collaboration to make the global value chain more resilient Speakers at the 5th Global Strategy Institute International Forum on October 28 stressed the importance of global collaboration for rebuilding the global economy and making innovations in national science and technology governance in order to enhance national competitiveness. The forum entitled “Grand Strategic Shift under Global Techno-Geopolitical Paradigm” examined strategies for making the global supply chain more resilient and rebuild the global economy as well as how Korea could advance in the technology race. Speakers concurred that technology has become an issue of national security. The global supply chain has been disrupted amid the global pandemic and intense conflict between the U.S. and China. Speakers presented a common solution: global collaboration and innovations in science and technology governance. KAIST President Kwang Hyung Lee said in his opening remarks that the future ‘world map’ may turn out very differently depending on how we prepare and what we envision for the future. He also stressed the importance of technology sovereignty, adding that only those who can create their own new technology independently will be the future leaders. Prime Minister Boo Kyum Kim and Vice Minister of Science and ICT Hongtaek Yong delivered congratulatory remarks. Keynote speakers included Professor Scott Stern from the MIT Sloan School of Management, Professor Aaron Chatterji from the Fuqua School of Business at Duke University, Professor Sarah Kreps from the Department of Government at Cornell University, SK Group Chairperson Tae-Won Chey, President Woo Il Lee of the Korean Federation of Science and Technology Societies, Professor Young Kwan Yoon at Seoul National University, President Eun Mee Kim of Ewha Womans University, and President Ieehwan Kim of the University of Science and Technology. During the first session, Professor Chatterji stressed that how to make supply chains resilience will be the key for making long-term strategy with relevant government policy. He said that AI has become a general purpose technology (GPT) and Korea ranked 4th in AI innovation in the world, but how to translate this innovativeness into national strategic leadership will be a new challenge for Korea. He suggested that Korea strengthen its strategic partnerships with allies such as the U.S. and provide opportunities not only for established players but start-ups and entrepreneurs. Meanwhile, Professor Kreps said that industrial policy should also leverage trust and innovations for building technology alliances with a more longer-term approach, without antagonizing certain groups of nations. Vice President for Planning and Budget Bowon Kim who joined the forum as a discussant pointed out that in this hyper-connected era, nothing can be manufactured in a single company and country without the global supply chain. “In longer-term policy and strategies, we should embrace China as a global economy partner and include all nations around the world.” Chairman Chey from SK said that the clear role among universities, industry, and the government doesn’t exist any longer. Now, universities are working hard for the commercialization of technology from their labs. Industry is nurturing the talents inept for future industry, and the government is trying to introduce a more private-sector approach. As such, universities, the government, and industry should embrace all-inclusive approaches encompassing global politics and trade to lead on the global stage. Meanwhile in the second session, all of the speakers stressed innovation in science and technology governance in order to adopt to the new industrial paradigm. They agreed to make prompt innovations and solid collaborative systems among the government ministries to ensure national competitiveness, especially in the field of science and technology. President Lee from KOFST said Korea should adopt a first mover strategy and the government should adopt a mission-oriented projects and deregulate more. He pointed out that when mandating more autonomy in decision making, scientists and students can make more creative outcomes. Professor Yoon at SNU stressed the close alliance with the U.S. in the technology race, but suggested that Korea should also seek ways to help minimize the technology gap between advanced and developing countries. Universities should also be allowed more autonomy in running creative curriculum and academic affairs to in order boost the competitiveness of science and technology. President Kim from Ewha pointed out the role of education as a public good. In some countries, strengthening science and technology can be accomplished with wider educational opportunities in middle and high schools. President Kim also stressed expanding strategic partnerships. She said Korea should expand its alliances and partnerships, not only with the U.S. but with European countries and other niche countries where certain technologies are superior. President Kim of UST stressed a new science and technology leadership is required to build technology sovereignty and the government should spearhead the deregulations of the government policy. This GSI forum was co-hosted by two think-tanks at KAIST, the Korea Policy Center for the Fourth Industrial Revolution (KPC4IR) and the Innovation Strategy and Policy Institute (ISPI).
2021.10.28
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Flexible Sensor-Integrated RFA Needle Leads to Smarter Medical Treatment
Clinical trial of flexible sensor-integrated radiofrequency ablation (RFA) needle tip monitors physical changes and steam pop Researchers have designed a thin polymeric sensor platform on a radiofrequency ablation needle to monitor temperature and pressure in real time. The sensors integrated onto 1.5 mm diameter needle tip have proven their efficacy during clinical tests and expect to provide a new opportunity for safer and more effective medical practices. The research was reported in Advanced Science as the frontispiece on August 5. Radiofrequency ablation (RFA) is a minimally invasive surgery technique for removing tumors and treating cardiovascular disease. During a procedure, an unintended audible explosion called ‘steam pop’ can occur due to the increased internal steam pressure in the ablation region. This phenomenon has been cited as a cause of various negative thermal and mechanical effects on neighboring tissue. Even more, the relationship between steam pop and cancer recurrence is still being investigated. Professor Inkyu Park said that his team’s integrated sensors reliably detected the occurrence of steam pop. The sensors also monitor rapidly spreading hot steam in tissue. It is expected that the diverse properties of tissue undergoing RFA could be checked by utilizing the physical sensors integrated on the needle. “We believe that the integrated sensors can provide useful information about a variety of medical procedures and accompanying environmental changes in the human body, and help develop more effective and safer surgical procedures,” said Professor Park. Professor Park’s team built a thin film type pressure and temperature sensor stack with a thickness of less than 10 μm using a microfabrication process. For the pressure sensor, the team used contact resistance changes between metal electrodes and a carbon nanotube coated polymeric membrane. The entire sensor array was thoroughly insulated with medical tubes to minimize any exposure of the sensor materials to external tissue and maximize its biocompatibility. During the clinical trial, the research team found that the accumulated hot steam is suddenly released during steam pops and this hot air spreads to neighboring tissue, which accelerates the ablation process. Furthermore, using in-situ ultrasound imaging and computational simulations, the research team could confirm the non-uniform temperature distribution around the RFA needle can be one of the primary reasons for the steam popping. Professor Park explained that various physical and chemical sensors for different targets can be added to create other medical devices and industrial tools. “This result will expand the usability and applicability of current flexible sensor technologies. We are also trying to integrate this sensor onto a 0.3mm diameter needle for in-vivo diagnosis applications and expect that this approach can be applied to other medical treatments as well as the industrial field,” added Professor Park. This study was supported by the National Research Foundation of Korea. -PublicationJaeho Park, Jinwoo Lee, Hyo Keun Lim, Inkyu Park et al. “Real-Time Internal Steam Pop Detection during Radiofrequency Ablation with a Radiofrequency Ablation Needle Integrated with a Temperature and Pressure Sensor: Preclinical and clinical pilot tests," Advanced Science (https://doi/org/10.1002/advs.202100725) on August 5, 2021 -ProfileProfessor Inkyu ParkMicro & Nano Tranducers Laboratory http://mintlab1.kaist.ac.kr/ Department of Mechanical EngineeringCollege of EngineeringKAIST
2021.10.20
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KAIST Entrepreneurial Partnership to Accelerate Startups and Venture Ecosystem
KAIST will launch the KAIST Entrepreneurial Partnership (KEP) program, which connects faculty members who own technology with those who want to launch startup. The program encourages open innovation startups using strategies tailored to market-client demand requirements. This is also one of efforts to help realize ‘one startup per lab,’ initiated by President Kwang Hyung Lee’s new innovation strategy. KEP also aims to introduce the best technologies developing at KAIST to startups and to raise the success rate of technology commercialization. The program will match KAIST faculty and student entrepreneur candidates with parties enrolled in the new Entrepreneur in Residence and Entrepreneurial Partner programs. Each team will be given a six-month test period with funding support. KAIST will invite entrepreneurial experts from both technology and management fields to support the program participants. Around 30 experts with experience in developing new businesses, startups, and investments in large corporations or venture companies will be recruited as entrepreneurial partners. They will offer support for research and business development (R&BD), technology marketing, attracting venture investment from corporations, mergers and acquisitions, and business openings. A survey showed that KAIST members who are interested in starting a business are experiencing difficulties finding an entrepreneurial expert (72.2%), with the complicated startup approval procedures (33.3%), and their lack of knowledge on entrepreneurship and funding (27.8%). The KEP program hopes to encourage KAIST faculty members and students who have well-developed business ideas and the appropriate technology but lack the capabilities to realize and develop them into a business. Associate Vice President of Startups Young-Tae Kim said, “We will develop KEP into KAIST’s distinct entrepreneurial support system and produce exemplary outcomes of faculty and student startups. We will spread the startup DNA and lead the building of a virtuous cycle between entrepreneurship and the venture ecosystem.”
2021.10.14
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Industrial Liaison Program to Provide Comprehensive Consultation Services
The ILP’s one-stop solutions target all industrial sectors including conglomerates, small and medium-sized enterprises, venture companies, venture capital (VC) firms, and government-affiliated organizations. The Industrial Liaison Center at KAIST launched the Industrial Liaison Program (ILP) on September 28, an industry-academic cooperation project to provide comprehensive solutions to industry partners. The Industrial Liaison Center will recruit member companies for this service every year, targeting all industrial sectors including conglomerates, small and medium-sized enterprises, venture companies, venture capital (VC) firms, and government-affiliated organizations. The program plans to build a one-stop support system that can systematically share and use excellent resource information from KAIST’s research teams, R&D achievements, and infrastructure to provide member companies with much-needed services. More than 40 KAIST professors with abundant academic-industrial collaboration experience will participate in the program. Experts from various fields with different points of view and experiences will jointly provide solutions to ILP member companies. To actively participate in academic-industrial liaisons and joint consultations, KAIST assigned 10 professors from related fields as program directors. The program directors will come from four different fields including AI/robots (Professor Alice Oh, School from the School of Computing, Professor Young Jae Jang from the Department of Industrial & Systems Engineering, and Professor Yong-Hwa Park from Department of Mechanical Engineering), bio/medicine (Professor Daesoo Kim from Department of Biological Sciences and Professor YongKeun Park from Department of Physics), materials/electronics (Professor Sang Ouk Kim from the Department of Materials Science and Engineering and Professors Jun-Bo Yoon and Seonghwan Cho from the School of Electrical Engineering), and environment/energy (Professor Hee-Tak Kim from the Department of Biological Sciences and Professor Hoon Sohn from the Department of Civil and Environmental Engineering). The transdisciplinary board of consulting professors that will lead technology innovation is composed of 30 professors including Professor Min-Soo Kim (School of Computing, AI), Professor Chan Hyuk Kim (Department of Biological Sciences, medicine), Professor Hae-Won Park (Department of Mechanical Engineering, robots), Professor Changho Suh (School of Electrical Engineering, electronics), Professor Haeshin Lee (Department of Chemistry, bio), Professor Il-Doo Kim (Department of Materials Science and Engineering, materials), Professor HyeJin Kim (School of Business Technology and Management), and Professor Byoung Pil Kim (School of Business Technology and Management, technology law) The Head of the Industrial Liaison Center who is also in charge of the program, Professor Keon Jae Lee, said, “In a science and technology-oriented generation where technological supremacy determines national power, it is indispensable to build a new platform upon which innovative academic-industrial cooperation can be pushed forward in the fields of joint consultation, the development of academic-industrial projects, and the foundation of new industries. He added, “KAIST professors carry out world-class research in many different fields and faculty members can come together through the ILP to communicate with representatives from industry to improve their corporations’ global competitiveness and further contribute to our nation’s interests by cultivating strong small enterprises
2021.09.30
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Deep Learning Framework to Enable Material Design in Unseen Domain
Researchers propose a deep neural network-based forward design space exploration using active transfer learning and data augmentation A new study proposed a deep neural network-based forward design approach that enables an efficient search for superior materials far beyond the domain of the initial training set. This approach compensates for the weak predictive power of neural networks on an unseen domain through gradual updates of the neural network with active transfer learning and data augmentation methods. Professor Seungwha Ryu believes that this study will help address a variety of optimization problems that have an astronomical number of possible design configurations. For the grid composite optimization problem, the proposed framework was able to provide excellent designs close to the global optima, even with the addition of a very small dataset corresponding to less than 0.5% of the initial training data-set size. This study was reported in npj Computational Materials last month. “We wanted to mitigate the limitation of the neural network, weak predictive power beyond the training set domain for the material or structure design,” said Professor Ryu from the Department of Mechanical Engineering. Neural network-based generative models have been actively investigated as an inverse design method for finding novel materials in a vast design space. However, the applicability of conventional generative models is limited because they cannot access data outside the range of training sets. Advanced generative models that were devised to overcome this limitation also suffer from weak predictive power for the unseen domain. Professor Ryu’s team, in collaboration with researchers from Professor Grace Gu’s group at UC Berkeley, devised a design method that simultaneously expands the domain using the strong predictive power of a deep neural network and searches for the optimal design by repetitively performing three key steps. First, it searches for few candidates with improved properties located close to the training set via genetic algorithms, by mixing superior designs within the training set. Then, it checks to see if the candidates really have improved properties, and expands the training set by duplicating the validated designs via a data augmentation method. Finally, they can expand the reliable prediction domain by updating the neural network with the new superior designs via transfer learning. Because the expansion proceeds along relatively narrow but correct routes toward the optimal design (depicted in the schematic of Fig. 1), the framework enables an efficient search. As a data-hungry method, a deep neural network model tends to have reliable predictive power only within and near the domain of the training set. When the optimal configuration of materials and structures lies far beyond the initial training set, which frequently is the case, neural network-based design methods suffer from weak predictive power and become inefficient. Researchers expect that the framework will be applicable for a wide range of optimization problems in other science and engineering disciplines with astronomically large design space, because it provides an efficient way of gradually expanding the reliable prediction domain toward the target design while avoiding the risk of being stuck in local minima. Especially, being a less-data-hungry method, design problems in which data generation is time-consuming and expensive will benefit most from this new framework. The research team is currently applying the optimization framework for the design task of metamaterial structures, segmented thermoelectric generators, and optimal sensor distributions. “From these sets of on-going studies, we expect to better recognize the pros and cons, and the potential of the suggested algorithm. Ultimately, we want to devise more efficient machine learning-based design approaches,” explained Professor Ryu.This study was funded by the National Research Foundation of Korea and the KAIST Global Singularity Research Project. -Publication Yongtae Kim, Youngsoo, Charles Yang, Kundo Park, Grace X. Gu, and Seunghwa Ryu, “Deep learning framework for material design space exploration using active transfer learning and data augmentation,” npj Computational Materials (https://doi.org/10.1038/s41524-021-00609-2) -Profile Professor Seunghwa Ryu Mechanics & Materials Modeling Lab Department of Mechanical Engineering KAIST
2021.09.29
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Professor Il-Doo Kim Receives the Science Minister’s Award
Professor Il-Doo Kim from the Department of Materials Science and Engineering received the Science and ICT Minister’s Award in recognition of his commercialization and technology transfer achievements during the Day of IP celebration. Professor Kim, who has made over 222 patents application and registration home and abroad, has advanced toxic gas detection and breath gas sensor technology by arraying nanosensor fibers. His technological advances in micro-electro-mechanical systems (MEMS) helped to advance the commercialization of the MEMS-related sensor and improve its overall competitiveness. He founded the Il-Doo Kim Research Center in 2019 and focuses on the commercialization of nanofiber manufacturing through electrospinning and highly efficient nanofiber filters. For instance, he succeeded in manufacturing a nano-filter recyclable mask that maintains excellent filtering efficiency even after hand washing through the development of proprietary technology that aligns nanofibers with a diameter of 100~500 nanometers in orthogonal or unidirectional directions. Professor Kim also serves as an associate editor at ACS Nano. He said, “The importance of IP goes without saying. I look forward to the registration and application of more KAIST patents leading to commercialization, paving the way for national technological competitiveness.”
2021.09.15
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The Dynamic Tracking of Tissue-Specific Secretory Proteins
Researchers develop a versatile and powerful tool for studying the spatiotemporal dynamics of secretory proteins, a valuable class of biomarkers and therapeutic targets Researchers have presented a method for profiling tissue-specific secretory proteins in live mice. This method is expected to be applicable to various tissues or disease models for investigating biomarkers or therapeutic targets involved in disease progression. This research was reported in Nature Communications on September 1. Secretory proteins released into the blood play essential roles in physiological systems. They are core mediators of interorgan communication, while serving as biomarkers and therapeutic targets. Previous studies have analyzed conditioned media from culture models to identify cell type-specific secretory proteins, but these models often fail to fully recapitulate the intricacies of multi-organ systems and thus do not sufficiently reflect biological realities. These limitations provided compelling motivation for the research team led by Jae Myoung Suh and his collaborators to develop techniques that could identify and resolve characteristics of tissue-specific secretory proteins along time and space dimensions. For addressing this gap in the current methodology, the research team utilized proximity-labeling enzymes such as TurboID to label secretory proteins in endoplasmic reticulum lumen using biotin. Thereafter, the biotin-labeled secretory proteins were readily enriched through streptavidin affinity purification and could be identified through mass spectrometry. To demonstrate its functionality in live mice, research team delivered TurboID to mouse livers via an adenovirus. After administering the biotin, only liver-derived secretory proteins were successfully detected in the plasma of the mice. Interestingly, the pattern of biotin-labeled proteins secreted from the liver was clearly distinctive from those of hepatocyte cell lines. First author Kwang-eun Kim from the Graduate School of Medical Science and Engineering explained, “The proteins secreted by the liver were significantly different from the results of cell culture models. This data shows the limitations of cell culture models for secretory protein study, and this technique can overcome those limitations. It can be further used to discover biomarkers and therapeutic targets that can more fully reflect the physiological state.” This work research was supported by the National Research Foundation of Korea, the KAIST Key Research Institutes Project (Interdisciplinary Research Group), and the Institute for Basic Science in Korea. -PublicationKwang-eun Kim, Isaac Park et al., “Dynamic tracking and identification of tissue-specific secretory proteins in the circulation of live mice,” Nature Communications on Sept.1, 2021(https://doi.org/10.1038/s41467-021-25546-y) -ProfileProfessor Jae Myoung Suh Integrated Lab of Metabolism, Obesity and Diabetes Researchhttps://imodkaist.wixsite.com/home Graduate School of Medical Science and Engineering College of Life Science and BioengineeringKAIST
2021.09.14
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How Stingrays Became the Most Efficient Swimmers in Nature
Study shows the hydrodynamic benefits of protruding eyes and mouth in a self-propelled flexible stingray With their compressed bodies and flexible pectoral fins, stingrays have evolved to become one of nature’s most efficient swimmers. Scientists have long wondered about the role played by their protruding eyes and mouths, which one might expect to be hydrodynamic disadvantages. Professor Hyung Jin Sung and his colleagues have discovered how such features on simulated stingrays affect a range of forces involved in propulsion, such as pressure and vorticity. Despite what one might expect, their research team found these protruding features actually help streamline the stingrays. ‘The influence of the 3D protruding eyes and mouth on a self-propelled flexible stingray and its underlying hydrodynamic mechanism are not yet fully understood,” said Professor Sung. “In the present study, the hydrodynamic benefit of protruding eyes and mouth was explored for the first time, revealing their hydrodynamic role.” To illustrate the complex interplay between hydrodynamic forces, the researchers set to work creating a computer model of a self-propelled flexible plate. They clamped the front end of the model and then forced it to mimic the up-and-down harmonic oscillations stingrays use to propel themselves. To re-create the effect of the eyes and mouth on the surrounding water, the team simulated multiple rigid plates on the model. They compared this model to one without eyes and a mouth using a technique called the penalty immersed boundary method. “Managing random fish swimming and isolating the desired purpose of the measurements from numerous factors was difficult,” Sung said. “To overcome these limitations, the penalty immersed boundary method was adopted to find the hydrodynamic benefits of the protruding eyes and mouth.” The team discovered that the eyes and mouth generated a vortex of flow in the forward-backward , which increased negative pressure at the simulated animal’s front, and a side-to-side vortex that increased the pressure difference above and below the stingray. The result was increased thrust and accelerated cruising. Further analysis showed that the eyes and mouth increased overall propulsion efficiency by more than 20.5% and 10.6%, respectively. Researchers hope their work, driven by curiosity, further stokes interest in exploring fluid phenomena in nature. They are hoping to find ways to adapt this for next-generation water vehicle designs based more closely on marine animals. This study was supported by the National Research Foundation of Korea and the State Scholar Fund from the China Scholarship Council. -ProfileProfessor Hyung Jin SungDepartment of Mechanical EngineeringKAIST -PublicationHyung Jin Sung, Qian Mao, Ziazhen Zhao, Yingzheng Liu, “Hydrodynamic benefits of protruding eyes and mouth in a self-propelled flexible stingray,” Aug.31, 2021, Physics of Fluids (https://doi.org/10.1063/5.0061287) -News release from the American Institute of Physics, Aug.31, 2021
2021.09.06
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Quantum Emitters: Beyond Crystal Clear to Single-Photon Pure
‘Nanoscale Focus Pinspot’ can quench only the background noise without changing the optical properties of the quantum emitter and the built-in photonic structure Photons, fundamental particles of light, are carrying these words to your eyes via the light from your computer screen or phone. Photons play a key role in the next-generation quantum information technology, such as quantum computing and communications. A quantum emitter, capable of producing a single, pure photon, is the crux of such technology but has many issues that have yet to be solved, according to KAIST researchers. A research team under Professor Yong-Hoon Cho has developed a technique that can isolate the desired quality emitter by reducing the noise surrounding the target with what they have dubbed a ‘nanoscale focus pinspot.’ They published their results on June 24 in ACS Nano. “The nanoscale focus pinspot is a structurally nondestructive technique under an extremely low dose ion beam and is generally applicable for various platforms to improve their single-photon purity while retaining the integrated photonic structures,” said lead author Yong-Hoon Cho from the Department of Physics at KAIST. To produce single photons from solid state materials, the researchers used wide-bandgap semiconductor quantum dots — fabricated nanoparticles with specialized potential properties, such as the ability to directly inject current into a small chip and to operate at room temperature for practical applications. By making a quantum dot in a photonic structure that propagates light, and then irradiating it with helium ions, researchers theorized that they could develop a quantum emitter that could reduce the unwanted noisy background and produce a single, pure photon on demand. Professor Cho explained, “Despite its high resolution and versatility, a focused ion beam typically suppresses the optical properties around the bombarded area due to the accelerated ion beam’s high momentum. We focused on the fact that, if the focused ion beam is well controlled, only the background noise can be selectively quenched with high spatial resolution without destroying the structure.” In other words, the researchers focused the ion beam on a mere pin prick, effectively cutting off the interactions around the quantum dot and removing the physical properties that could negatively interact with and degrade the photon purity emitted from the quantum dot. “It is the first developed technique that can quench the background noise without changing the optical properties of the quantum emitter and the built-in photonic structure,” Professor Cho asserted. Professor Cho compared it to stimulated emission depletion microscopy, a technique used to decrease the light around the area of focus, but leaving the focal point illuminated. The result is increased resolution of the desired visual target. “By adjusting the focused ion beam-irradiated region, we can select the target emitter with nanoscale resolution by quenching the surrounding emitter,” Professor Cho said. “This nanoscale selective-quenching technique can be applied to various material and structural platforms and further extended for applications such as optical memory and high-resolution micro displays.” Korea’s National Research Foundation and the Samsung Science and Technology Foundation supported this work. -PublicationMinho Choi, Seongmoon Jun, and Yong-Hoon Cho et al. ACS Nano‘Nanoscale Focus Pinspot for High-Purity Quantum Emitters via Focused-Ion-Beam-Induced Luminescence Quenching,’(https://pubs.acs.org/doi/10.1021/acsnano.1c00587) -ProfileProfessor Yong-Hoon ChoQuantum & Nanobio Photonics Laboratoryhttp://qnp.kaist.ac.kr/ Department of PhysicsKAIST
2021.09.02
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