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KAIST–Princeton University Officially Launch “Net-Zero Korea” to Address Climate Crisis
KAIST (President Kwang Hyung Lee) announced on the 27th of August that a research team led by Professor Hae-Won Jeon of the Graduate School of Green Growth and Sustainable Development has signed a memorandum of understanding (MOU) with the Andlinger Center for Energy and the Environment at Princeton University in the United States to promote joint research on carbon neutrality, officially launching the Net-Zero Korea (NZK) project. This project was unveiled at the World Climate Industry EXPO (WCE) held in BEXCO, Busan, and will begin with seed funding from Google.
The NZK project aims, in the short term, to accelerate the transition of Korea’s energy and industrial sectors toward carbon neutrality, and in the mid- to long term, to strengthen Korea’s energy system modeling capabilities for policy formulation and implementation. Energy system modeling plays a critical role in studying the transition to clean energy and carbon neutrality.
In particular, this research plans to apply Princeton’s leading modeling methodologies from the Net-Zero America project—published in 2021 and widely recognized—to the Korean context by integrating them with KAIST’s integrated assessment modeling research.
The Net-Zero Korea project will be supported by funding from Google, KAIST, and Princeton University. This research is characterized by its detailed analysis of a wide range of factors, from regional land-use changes to job creation, and by concretely visualizing the resulting transformations in energy and industrial systems. It will also be conducted through an international collaborative network while reflecting Korea’s specific conditions. In particular, KAIST will develop an optimization-based open-source energy and industrial system model that integrates the effects of international trade, thereby contributing to global academia and policy research.
Therefore, the core of this modeling research is to apply to Korea the precise analysis and realistic approach that drew attention in Net-Zero America. Through this, it will be possible to visualize changes in the energy and industrial systems at high spatial, temporal, sectoral, and technological resolution, and to comprehensively analyze various factors such as regional land-use changes, capital investment requirements, job creation, and health impacts from air pollution. This will provide stakeholders with practical and reliable information.
In addition, the KAIST research team will collaborate with Princeton researchers, who have conducted national-scale decarbonization modeling studies with major research institutions in Australia, Brazil, China, India, Poland, and others, leveraging a global research network for joint studies.
Building on its experience in developing globally recognized integrated assessment models (IAM) tailored to Korea, KAIST will lead a new initiative to integrate international trade impacts into optimization-based open-source energy and industrial system models. This effort seeks to overcome the limitations of existing national energy modeling by reflecting the particularity of Korea, where trade plays a vital role across the economy.
Professor Wei Peng, Princeton’s principal investigator, said: “Through collaboration with KAIST’s world-class experts in integrated assessment modeling, we will be able to build new research that combines the strengths of macro-energy models and integrated assessment models, thereby developing capabilities applicable to many countries where trade plays a crucial role in the economy, such as Korea.”
Antonia Gawel, Director of Partnerships at Google, stated: “We are very pleased to support this meaningful research being conducted by KAIST and Princeton University in Korea. It will greatly help Google achieve our goal of net-zero emissions across our supply chain by 2030.”
Professor Haewon McJeon of KAIST commented: “Through joint research with Princeton University, which has been leading net-zero studies, we expect to provide science-based evidence to support Korea’s achievement of carbon neutrality and sustainable energy.”
President Kwang Hyung Lee of KAIST remarked: “It is deeply meaningful that KAIST, as Korea’s representative research institution, joins hands with Princeton University, a leading institution in the United States, to jointly build a science-based policy support system for responding to the climate crisis. This collaboration will contribute not only to achieving carbon neutrality in Korean society but also to the global response to the climate crisis.”
2025.08.28 View 4251 -
Professor Sung Yong Kim Publishes English Book, 'A Cup of Coffee and the Ocean'
<Professor Sung Yong Kim from Department of Mechanical Engineering>
Professor Sung Yong Kim of the Department of Mechanical Engineering announced the publication of his English book, ‘A Cup of Coffee and the Ocean: Basics of Ocean Dynamics for Everyone’, by the world-renowned academic publisher Springer Nature on August 22nd. The book was designed to easily explain the basics of the ocean, various physical phenomena, and safety common sense to high school students, university students, and the general public, using the familiar subject of coffee.
Professor Kim previously published 'Coffee and the Ocean,' Volume 34 of the 'Scholars Talk about Science and Technology' series, with support from the Korean Academy of Science and Technology in 2019. The new English edition is a rewrite based on that content, targeting an international readership.
The book explains the characteristics of fluids found in everyday coffee, expanding this to illustrate fluid phenomena in the ocean, and also includes various ocean-related safety tips. The goal is to help readers understand the principles of fluids and raise awareness of marine safety. Furthermore, it emphasizes that understanding the ocean is directly connected to national competence and includes a plea from the perspective of an oceanographer.
Professor Kim commented, "The ocean is a global shared space that is not limited by the boundaries of specific regions. This English book was published to broaden the understanding of the ocean not just domestically but among readers worldwide. Through this, I hope to see more oceanographers with a sense of mission who can see the bigger picture."
Book Cover Image
< Book Cover Image >
Related Book Links:
(Link for KAIST Insiders)
https://link-springer-com.libra.kaist.ac.kr/book/10.1007/978-981-96-6835-9
(Link for the General Public)
https://link.springer.com/book/10.1007/978-981-96-6835-9
< QR Code Linking to the Site >
This book was introduced on the UN Ocean Decade official website, and its significance is further amplified by its subject matter being closely aligned with the UN Sustainable Development Goals (SDGs).Furthermore, Professor Nadia Pinardi, who specializes in Physical Oceanography at the University of Bologna (Università di Bologna) in Italy, has communicated that the university plans to translate the book into Italian and utilize it as a textbook for marine education across Italy starting in 2027.The search results include a video featuring Professor Nadia Pinardi discussing sea level rise and coastal adaptation.
https://oceandecade.org/publications/a-cup-of-coffee-and-the-ocean-the-basics-of-ocean-dynamics/
2025.08.27 View 763 -
KAIST achieves over 95% high-purity CO₂ capture using only smartphone charging power
Direct Air Capture (DAC) is a technology that filters out carbon dioxide present in the atmosphere at extremely low concentrations (below 400 ppm). The KAIST research team has now succeeded in capturing over 95% high-purity carbon dioxide using only low power at the level of smartphone charging voltage (3V), without hot steam or complex facilities. While high energy cost has been the biggest obstacle for conventional DAC technologies, this study is regarded as a breakthrough demonstrating real commercialization potential. Overseas patent applications have already been filed, and because it can be easily linked with renewable energy such as solar and wind power, the technology is being highlighted as a “game changer” for accelerating the transition to carbon-neutral processes.
KAIST (President Kwang Hyung Lee) announced on the 25th of August that Professor Dong-Yeun Koh’s research team from the Department of Chemical and Biomolecular Engineering, in collaboration with Professor T. Alan Hatton’s group at MIT’s Department of Chemical Engineering, has developed the world’s first ultra-efficient e-DAC (Electrified Direct Air Capture) technology based on conductive silver nanofibers.
Conventional DAC processes required high-temperature steam (over 100℃) in the regeneration stage, where absorbed or adsorbed carbon dioxide is separated again. This process consumes about 70% of the total energy, making energy efficiency crucial, and requires complex heat-exchange systems, which makes cost reduction difficult. The joint research team, led by KAIST, solved this problem with “fibers that heat themselves electrically,” adopting Joule heating, a method that generates heat by directly passing electricity through fibers, similar to an electric blanket. By heating only where needed without an external heat source, energy loss was drastically reduced.
This technology can rapidly heat fibers to 110℃ within 80 seconds with only 3V—the energy level of smartphone charging. This shortens adsorption–desorption cycles dramatically even in low-power environments, while reducing unnecessary heat loss by about 20% compared to existing technologies.
The core of this research was not just making conductive fibers, but realizing a “breathable conductive coating” that achieves both “electrical conductivity” and “gas diffusion.”
The team uniformly coated porous fiber surfaces with a composite of silver nanowires and nanoparticles, forming a layer about 3 micrometers (µm) thick—much thinner than a human hair. This “3D continuous porous structure” allowed excellent electrical conductivity while securing pathways for CO₂ molecules to move smoothly into the fibers, enabling uniform, rapid heating and efficient CO₂ capture simultaneously.
Furthermore, when multiple fibers were modularized and connected in parallel, the total resistance dropped below 1 ohm (Ω), proving scalability to large-scale systems. The team succeeded in recovering over 95% high-purity CO₂ under real atmospheric conditions.
This achievement was the result of five years of in-depth research since 2020. Remarkably, in late 2022, long before the paper’s publication, the core technology had already been filed for PCT and domestic/international patents (WO2023068651A1, countries entered: US, EP, JP, AU, CN), securing foundational intellectual property rights. This indicates that the technology is not only highly advanced but also developed with practical commercialization in mind beyond the laboratory level.
The biggest innovation of this technology is that it runs solely on electricity, making it very easy to integrate with renewable energy sources such as solar and wind. It perfectly matches the needs of global companies that have declared RE100 and seek carbon-neutral process transitions.
Professor Dong-Yeun Koh of KAIST said, “Direct Air Capture (DAC) is not just a technology for reducing carbon dioxide emissions, but a key means of achieving ‘negative emissions’ by purifying the air itself. The conductive fiber-based DAC technology we developed can be applied not only to industrial sites but also to urban systems, significantly contributing to Korea’s leap as a leading nation in future DAC technologies.”
This study was led by Young Hun Lee (PhD, 2023 graduate of KAIST; currently at MIT Department of Chemical Engineering) and co-first-authored by Jung Hun Lee and Hwajoo Joo (MIT, Department of Chemical Engineering). The results were published online on August 1, 2025, in Advanced Materials, one of the world’s leading journals in materials science, and in recognition of its excellence, the work was also selected for the Front Inside Cover.
※ Paper title: “Design of Electrified Fiber Sorbents for Direct Air Capture with Electrically-Driven Temperature Vacuum Swing Adsorption”
※ DOI: https://doi.org/10.1002/adma.202504542
This study was supported by the Aramco–KAIST CO₂ Research Center and the National Research Foundation of Korea with funding from the Ministry of Science and ICT (No. RS-2023-00259416, DACU Source Technology Development Project).
2025.08.25 View 4013 -
KAIST-KBSI, ‘Communication’ Between Proteins Found to Mitigate Alzheimer’s Toxicity… Opening the Path to Treatment
50 million people worldwide are estimated to have dementia, with Alzheimer’s disease—accounting for over 70%—being the representative neurodegenerative brain disorder. A Korean research team has, for the first time in the world, identified at the molecular level that tau and amyloid-β, the two key pathological proteins of Alzheimer’s disease, directly communicate to regulate toxicity. This achievement is expected to provide new insights into the pathophysiology of Alzheimer’s disease, as well as important clues for discovering biomarkers for early diagnosis and developing therapeutics for neurodegenerative brain disorders.
KAIST (President Kwang Hyung Lee) announced on the 24th of August that Professor Mi Hee Lim’s research team in the Department of Chemistry (Director of the Research Center for Metal–Neuroprotein Interactions), in collaboration with Dr. Young-Ho Lee’s team from the Division of Advanced Biomedical Research at the Korea Basic Science Institute (KBSI, President Sung-kwang Yang) under the National Research Council of Science & Technology (NST, Chairperson Yeung-Shik Kim), together with Dr. Yun Kyung Kim and Dr. Sung Su Lim from the Brain Science Institute at the Korea Institute of Science and Technology (KIST, President Sang-Rok Oh), has elucidated at the molecular level that the microtubule-binding domain of tau—one of the major pathological proteins of Alzheimer’s disease—directly interacts with amyloid-β (tau–amyloid-β communication), alters its aggregation pathway, and alleviates cellular toxicity.
Pathologically, Alzheimer’s disease is characterized by the accumulation of“neurofibrillary tangles” formed by aggregates of tau, a protein responsible for transporting nutrients and signaling molecules within neurons, and “amyloid plaques (senile plaques)” formed by clusters of amyloid-β fragments—abnormally cleaved from amyloid precursor protein, which is involved in brain development, intercellular signaling, and neuronal recovery—that aggregate in and around neuronal membranes in the brain.
Although tau and amyloid-β form pathological structures in spatially separated locations, it has been suggested that they may coexist inside and outside of cells and potentially interact. However, the molecular-level understanding of how their direct interaction affects the onset and progression of the disease has not been clearly revealed until now.
The joint research team found that among the structural repeats of tau protein that bind to microtubules (the intracellular transport system) inside neurons—K18, R1–R4, PHF6*, and PHF6—specifically K18, R2, and R3 bind with amyloid-β to form ‘tau–amyloid-β heterocomplexes.’ This process is significant because amyloid-β normally assembles into highly toxic, rigid fibers (amyloid fibrils), but when certain tau regions bind, amyloid-β shifts to an aggregation pathway that produces less toxic, less rigid aggregates.
Notably, these repeat regions of tau delay the nucleation stage (the initial step of amyloid aggregation linked to disease onset) and simultaneously alter the aggregation speed and structural form of amyloid-β associated with disease progression. As a result, the toxicity caused by amyloid-β was markedly reduced in both the intracellular and extracellular environments of the brain.
In this study, the team combined precise analytical techniques—including spectroscopy, mass spectrometry, isothermal titration calorimetry, and nuclear magnetic resonance—with cell-based toxicity assays to comprehensively analyze the structural, thermodynamic, and functional properties of tau–amyloid interactions.
The findings revealed that specific regions of tau’s microtubule-binding repeats possess both hydrophilic (water-attracting) and hydrophobic (water-repelling) characteristics, and when the balance of these two properties is optimized, tau binds more effectively to amyloid-β. In other words, the intrinsic properties of tau determine its binding affinity with amyloid-β, its modulation of aggregation pathways, and its ability to regulate toxicity.
Dr. Young-Ho Lee of KBSI stated, “This research has uncovered a new molecular mechanism for the onset and progression of dementia, an intractable neurodegenerative disease. In particular, multidisciplinary convergent research focused on molecular interactions and protein aggregation is expected to play a pivotal role in clarifying not only the cross-talk between Alzheimer’s and Parkinson’s diseases but also the interconnections among various diseases such as dementia, diabetes, and cancer.”
Professor Mi Hee Lim of KAIST added, “Tau protein does not merely contribute to pathological formation, but rather, through specific microtubule-binding repeat structures, it exerts a molecular function that actively mitigates amyloid-β aggregation and toxicity. This provides a new turning point in the pathological understanding of Alzheimer’s disease. The significance of this study lies in identifying new molecular motifs that could serve as therapeutic targets not only for Alzheimer’s but also for a variety of protein aggregation-based neurodegenerative brain disorders.”
This research, with Dr. Min Geun Kim of KAIST’s Department of Chemistry as first author, was published on August 22 in the internationally renowned journal Nature Chemical Biology (Impact factor: 13.7, top 3.8% in the field of chemistry).
※ Paper Title: “Interactions with tau’s microtubule-binding repeats modulate amyloid-β aggregation and toxicity”
※ DOI: 10.1038/s41589-025-01987-0
This research was supported by the National Research Foundation of Korea’s Basic Research Program (Leader Research and Mid-career Researcher Program), the Sejong Science Fellowship, as well as KBSI and KIST.
2025.08.25 View 4443 -
“Why are we depressed?” KAIST is identifying the cause of depression and uncovering clues for treatment
Major depressive disorder (MDD) is one of the most common psychiatric illnesses worldwide, but its molecular causes* have still not been clearly identified. A domestic research team has discovered that depression may not simply be caused by neuronal damage, but can also arise from the dysregulation of specific neural signaling pathways. In particular, they identified the molecular reason why elderly patients with depression do not respond to conventional antidepressants. This study suggests the possibility of therapeutic approaches using optogenetic technology to regulate neural signaling, and it provides clues for the development of new treatment strategies targeting the protein ‘Numb’ protein for elderly patients with depression.
*Molecular causes: explanations for the origin of a disease at the level of molecules, proteins, or genes in the brain.
KAIST (President Kwang Hyung Lee) announced on the 19th of August that a research team led by Distinguished Professor Won Do Heo of the Department of Biological Sciences at KAIST, in collaboration with forensic pathologist Minju Lee of the National Forensic Service (Director Bong Woo Lee) and Professor Seokhwi Kim of the Department of Pathology at Ajou University Medical Center (Director Sangwook Han), identified a new molecular mechanism for depression through RNA sequencing and the immunohistochemical analysis of brain tissue from patients who had committed suicide. Furthermore, they demonstrated in animal models that antidepressant effects can be restored by regulating the signaling pathway that induces neural recovery using optogenetic technology.
The research team focused on the hippocampus, the brain region responsible for memory and emotion, and in particular on the dentate gyrus (DG). The DG is the entry point of information into the hippocampus, playing a role in new memory formation, neurogenesis, and emotional regulation, and is closely linked with depression.
Using two representative mouse models for depression (the corticosterone stress model and the chronic unpredictable stress model), the team found that stress induced a striking increase in the signaling receptor FGFR1 (Fibroblast Growth Factor Receptor 1) in the DG. FGFR1 receives growth factor (FGF) signals and transmits growth and differentiation commands within cells.
Subsequently, using conditional knockout (cKO) mice in which the FGFR1 gene was deleted, the researchers revealed that the absence of FGFR1 made mice more vulnerable to stress and led them to exhibit depressive symptoms more quickly. This indicates that FGFR1 plays a critical role in proper neural regulation and stress resistance.
The team then developed an ‘optoFGFR1 system’ using optogenetics, enabling FGFR1 —essential for stress resistance—to be activated by light. They observed that activating FGFR1 in depression mouse models lacking FGFR1 restored antidepressant effects. In other words, they experimentally demonstrated that the activation of FGFR1 signaling alone could improve depressive behavior.
Surprisingly, however, in aged depression mouse models, the activation of FGFR1 signaling through the optoFGFR1 system did not yield antidepressant effects. Investigating further, the researchers found that in the aged brains, a protein called ‘Numb’ was excessively expressed and interfered with FGFR1 signaling.
Indeed, analysis of postmortem human brain tissue also showed the specific overexpression of Numb protein only in elderly patients with depression. When the researchers suppressed Numb using a gene regulatory tool (shRNA) while simultaneously activating FGFR1 signaling in mouse models, neurogenesis and behavior—previously unrecoverable—returned to normal even in aged depression models. This shows that the Numb protein acts as a “blocker” of FGFR1 signaling and is a key factor preventing the hippocampus from executing antidepressant mechanisms.
Distinguished Professor Won Do Heo of KAIST said, “This study is meaningful in that it revealed that depression may not only result from simple neuronal damage, but can also arise from the dysregulation of specific neural signaling pathways. In particular, we identified the molecular reason why antidepressants are less effective in elderly patients, and we expect this to provide a clue for the development of new therapeutic strategies targeting the Numb protein.”
He added, “Moreover, this interdisciplinary study, which combined KAIST’s expertise in neuroscience with the National Forensic Service’s forensic brain analysis technologies, is expected to serve as a bridge between basic research on psychiatric disorders and clinical applications.”
This study, led by first author Jongpil Shin, a PhD student in the Department of Biological Sciences at KAIST, was published on August 15, 2025, in the international journal Experimental & Molecular Medicine.
Paper title: “Dysregulation of FGFR1 signaling in the hippocampus facilitates depressive disorder”
DOI: https://doi.org/10.1038/s12276-025-01519-9
This research was supported by the Ministry of Science and ICT’s National Research Foundation of Korea through the ASTRA program and the Bio-Medical Technology Development project.
2025.08.19 View 3196 -
KAIST Takes the Lead in Developing Core Technologies for Generative AI National R&D Project
KAIST announced on the 15th of August that Professor Sanghoo Park of the Department of Nuclear and Quantum Engineering has won two consecutive awards for early-career researchers at two of the world's most prestigious plasma academic conferences.
Professor Park was selected as a recipient of the Early Career Award (ECA) at the Gaseous Electronics Conference (GEC), hosted by the American Physical Society, on August 4. He was also honored with the Young Investigator Award, presented by the International Plasma Chemistry Society (IPCS), on June 19.
The American Physical Society's GEC Early Career Award is given to only one person worldwide every two years, based on a comprehensive evaluation of research excellence, academic influence, and contributions to the field of plasma. The award will be presented at GEC 2025, which will be held at COEX in Seoul from October 13 to 17.
Established in 1948, the GEC is a leading academic conference in the plasma field with a 77-year history of showcasing key research achievements in all areas of plasma, including physics, chemistry, diagnostics, and application technologies. Recently, advanced application research such as eco-friendly chemical processes, next-generation semiconductors, and atomic layer and ultra-low-temperature etching technology for HBM processes have been gaining attention.
To commemorate the award, Professor Park will give an invited lecture at GEC 2025 on the topic of "Deep-Learning-Based Spectroscopic Data Analysis for Advancing Plasma Spectroscopy." In his lecture, he will use case studies to demonstrate a method that allows even non-specialists to easily and quickly perform spectroscopic data analysis—which is essential for spectroscopy, a key analytical method in modern science including plasma diagnostics—by using deep learning technology.
Professor Park also won the Young Investigator Award from the IPCS at the 26th International Symposium on Plasma Chemistry (ISPC 26), which was held in Minneapolis, USA, from June 15 to 20.
First held in 1973, the ISPC (International Symposium on Plasma Chemistry) is a representative international conference in the field of plasma chemistry, held biennially. It covers a wide range of topics, from basic plasma chemical reaction principles to applications in semiconductor processes, green energy, environmental science, and biotechnology. Researchers from industry, academia, and research institutions worldwide share their latest findings at each event. The Young Investigator Award is given to a scientist who has obtained their doctorate within the last 10 years and has demonstrated outstanding achievements in the field.
Professor Park was recognized for his leading research achievements in using plasma-liquid interactions and real-time optical diagnostic technology to environmentally fix nitrogen from the air and precisely control the quantity and types of reactive chemical species that are beneficial to the human body and the environment.
Professor Sanghoo Park stated, "It is very meaningful to receive the Young Investigator Award representing Korea at the GEC event, which is being held in Korea for the first time in its history." He added, "I am happy that my consistent interest in and achievements in fundamental plasma science have been recognized, and it is even more significant that the efforts of the KAIST research team have been acknowledged by the world's top conferences."
2025.08.16 View 3630 -
KAIST develops world’s most sensitive light-powered photodetector—20 times more sensitive, operating without electricity
<(From left) Ph.D candidate Jaeha Hwang, Ph.D candidate Jungi Song ,Professor Kayoung Lee from Electrical Engineering>
Silicon semiconductors used in existing photodetectors have low light responsivity, and the two-dimensional semiconductor MoS₂ (molybdenum disulfide) is so thin that doping processes to control its electrical properties are difficult, limiting the realization of high-performance photodetectors. The KAIST research team has overcome this technical limitation and developed the world’s highest-performing self-powered photodetector, which operates without electricity in environments with a light source. This paves the way for an era where precise sensing is possible without batteries in wearable devices, biosignal monitoring, IoT devices, autonomous vehicles, and robots, as long as a light source is present.
KAIST (President Kwang Hyung Lee) announced on the 14th of August that Professor Kayoung Lee’s research team from the School of Electrical Engineering has developed a self-powered photodetector that operates without external power supply. This sensor demonstrated a sensitivity up to 20 times higher than existing products, marking the highest performance level among comparable technologies reported to date.
Professor Kayoung Lee’s team fabricated a “PN junction structure” photodetector capable of generating electrical signals on its own in environments with light, even without an electrical energy supply, by introducing a “van der Waals bottom electrode” that makes semiconductors extremely sensitive to electrical signals without doping.
First, a “PN junction” is a structure formed by joining p-type (hole-rich) and n-type (electron-rich) materials in a semiconductor. This structure causes current to flow in one direction when exposed to light, making it a key component in photodetectors and solar cells.
Normally, to create a proper PN junction, a process called “doping” is required, which involves deliberately introducing impurities into the semiconductor to alter its electrical properties. However, two-dimensional semiconductors such as MoS₂ are only a few atoms thick, so doping in the conventional way can damage the structure or reduce performance, making it difficult to create an ideal PN junction.
To overcome these limitations and maximize device performance, the research team designed a new device structure incorporating two key technologies: the “van der Waals electrode” and the “partial gate.”
The “partial gate” structure applies an electrical signal only to part of the two-dimensional semiconductor, controlling one side to behave like p-type and the other like n-type. This allows the device to function electrically like a PN junction without doping.
Furthermore, considering that conventional metal electrodes can chemically bond strongly to the semiconductor and damage its lattice structure, the “van der Waals bottom electrode” was attached gently using van der Waals forces. This preserved the original structure of the two-dimensional semiconductor while ensuring effective electrical signal transfer.
This innovative approach secured both structural stability and electrical performance, enabling the realization of a PN junction in thin two-dimensional semiconductors without damaging their structure.
Thanks to this innovation, the team succeeded in implementing a high-performance PN junction without doping. The device can generate electrical signals with extreme sensitivity as long as there is light, even without an external power source. Its light detection sensitivity (responsivity) exceeds 21 A/W, more than 20 times higher than powered conventional sensors, 10 times higher than silicon-based self-powered sensors, and over twice as high as existing MoS₂ sensors. This level of sensitivity means it can be applied immediately to high-precision sensors capable of detecting biosignals or operating in dark environments.
Professor Kayoung Lee stated that they “have achieved a level of sensitivity unimaginable in silicon sensors, and although two-dimensional semiconductors are too thin for conventional doping processes, [they] succeeded in implementing a PN junction that controls electrical flow without doping.” She added, “This technology can be used not only in sensors but also in key components that control electricity inside smartphones and electronic devices, providing a foundation for miniaturization and self-powered operation of next-generation electronics.”
Jaeha Hwang, Jungi Song, Experimnet in Porgress>
This research, with doctoral students Jaeha Hwang and Jungi Song as co-first authors, was published online on July 26 in Advanced Functional Materials (IF 19), a leading journal in materials science.
※ Paper title: Gated PN Junction in Ambipolar MoS₂ for Superior Self-Powered Photodetection
※ DOI: https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202510113
Meanwhile, this work was supported by the National Research Foundation of Korea, the Korea Basic Science Institute, Samsung Electronics, and the Korea Institute for Advancement of Technology.
2025.08.16 View 3545 -
Professor Mikyoung Lim from Mathematical Sciences to Deliver Keynote at International Conference on Applied Inverse Problems
Professor Mikyoung Lim from KAIST Department of Mathematical Sciences gave a plenary talk on "Research on Inverse Problems based on Geometric Function Theory" at AIP 2025 (12th Applied Inverse Problems Conference). AIP is one of the leading international conferences in applied mathematics, organized biennially by the Inverse Problems International Association (IPIA). This year's conference was held from July 28 to August 1 in Rio de Janeiro, Brazil, and consisted of plenary talks, over 40 mini-symposia, and poster sessions. The IPIA began in 2007 and was re-established in 2022 as a non-profit international academic organization officially registered in Germany. At that time, Professor Lim served as an executive committee member for the re-establishment.
During the lecture, Professor Lim's research team introduced a new geometric solution and its applications to boundary value problems for electric/elastic equations, which they have been working on for the past 10 years. In particular, they presented a method for reconstructing partial differential equation boundary value problems into matrix equations and applying them to inverse problems using geometric function theory, a classical theory of complex analysis. A representative achievement was the formalization of the relationship between conformal mappings for simply connected domains in a plane and the measured values of solutions to equations of inhomogeneous conductors into a closed-form expression.
This research led to the plenary talk, as it was recognized for pioneering a new methodology for inverse problem research by connecting geometric function theory and layer potential theory.
2025.08.14 View 3649 -
KAIST Develops World’s First Wireless OLED Contact Lens for Retinal Diagnostics
<ID-style photograph against a laboratory background featuring an OLED contact lens sample (center), flanked by the principal authors (left: Professor Seunghyup Yoo ; right: Dr. Jee Hoon Sim). Above them (from top to bottom) are: Professor Se Joon Woo, Professor Sei Kwang Hahn, Dr. Su-Bon Kim, and Dr. Hyeonwook Chae>
Electroretinography (ERG) is an ophthalmic diagnostic method used to determine whether the retina is functioning normally. It is widely employed for diagnosing hereditary retinal diseases or assessing retinal function decline.
A team of Korean researchers has developed a next-generation wireless ophthalmic diagnostic technology that replaces the existing stationary, darkroom-based retinal testing method by incorporating an “ultrathin OLED” into a contact lens. This breakthrough is expected to have applications in diverse fields such as myopia treatment, ocular biosignal analysis, augmented-reality (AR) visual information delivery, and light-based neurostimulation.
On the 12th, KAIST (President Kwang Hyung Lee) announced that a research team led by Professor Seunghyup Yoo from the School of Electrical Engineering, in collaboration with Professor Se Joon Woo of Seoul National University Bundang Hospital (Director Jeong-Han Song), Professor Sei Kwang Hahn of POSTECH (President Sung-Keun Kim) and CEO of PHI Biomed Co., and the Electronics and Telecommunications Research Institute (ETRI, President Seungchan Bang) under the National Research Council of Science & Technology (NST, Chairman Youngshik Kim), has developed the world’s first wireless contact lens-based wearable retinal diagnostic platform using organic light-emitting diodes (OLEDs).
<Figure 1. Schematic and photograph of the wireless OLED contact lens>
This technology enables ERG simply by wearing the lens, eliminating the need for large specialized light sources and dramatically simplifying the conventional, complex ophthalmic diagnostic environment.
Traditionally, ERG requires the use of a stationary Ganzfeld device in a dark room, where patients must keep their eyes open and remain still during the test. This setup imposes spatial constraints and can lead to patient fatigue and compliances challenges.
To overcome these limitations, the joint research team integrated an ultrathin flexible OLED —approximately 12.5 μm thick, or 6–8 times thinner than a human hair— into a contact lens electrode for ERG. They also equipped it with a wireless power receiving antenna and a control chip, completing a system capable of independent operation.
For power transmission, the team adopted a wireless power transfer method using a 433 MHz resonant frequency suitable for stable wireless communication. This was also demonstrated in the form of a wireless controller embedded in a sleep mask, which can be linked to a smartphone —further enhancing practical usability.
<Figure 2. Schematic of the electroretinography (ERG) testing system using a wireless OLED contact lens and an example of an actual test in progress>
While most smart contact lens–type light sources developed for ocular illumination have used inorganic LEDs, these rigid devices emit light almost from a single point, which can lead to excessive heat accumulation and thus usable light intensity. In contrast, OLEDs are areal light sources and were shown to induce retinal responses even under low luminance conditions. In this study, under a relatively low luminance* of 126 nits, the OLED contact lens successfully induced stable ERG signals, producing diagnostic results equivalent to those obtained with existing commercial light sources.
*Luminance: A value indicating how brightly a surface or screen emits light; for reference, the luminance of a smartphone screen is about 300–600 nits (can exceed 1000 nits at maximum).
Animal tests confirmed that the surface temperature of a rabbit’s eye wearing the OLED contact lens remained below 27°C, avoiding corneal heat damage, and that the light-emitting performance was maintained even in humid environments—demonstrating its effectiveness and safety as an ERG diagnostic tool in real clinical settings.
Professor Seunghyup Yoo stated that “integrating the flexibility and diffusive light characteristics of ultrathin OLEDs into a contact lens is a world-first attempt,” and that “this research can help expand smart contact lens technology into on-eye optical diagnostic and phototherapeutic platforms, contributing to the advancement of digital healthcare technology.”
< Wireless operation of the OLED contact lens >
Jee Hoon Sim, Hyeonwook Chae, and Su-Bon Kim, PhD researchers at KAIST, played a key role as co-first authors alongside Dr. Sangbaie Shin of PHI Biomed Co.. Corresponding authors are Professor Seunghyup Yoo (School of Electrical Engineering, KAIST), Professor Sei Kwang Hahn (Department of Materials Science and Engineering, POSTECH), and Professor Se Joon Woo (Seoul National University Bundang Hospital). The results were published online in the internationally renowned journal ACS Nano on May 1st.
● Paper title: Wireless Organic Light-Emitting Diode Contact Lenses for On-Eye Wearable Light Sources and Their Application to Personalized Health Monitoring
● DOI: https://doi.org/10.1021/acsnano.4c18563
● Related video clip: http://bit.ly/3UGg6R8
< Close-up of the OLED contact lens sample >
2025.08.12 View 4856 -
KAIST Develops AI That Automatically Designs Optimal Drug Candidates for Cancer-Targeting Mutations
< (From left) Ph.D candidate Wonho Zhung, Ph.D cadidate Joongwon Lee , Prof. Woo Young Kim , Ph.D candidate Jisu Seo >
Traditional drug development methods involve identifying a target protin (e.g., a cancer cell receptor) that causes disease, and then searching through countless molecular candidates (potential drugs) that could bind to that protein and block its function. This process is costly, time-consuming, and has a low success rate. KAIST researchers have developed an AI model that, using only information about the target protein, can design optimal drug candidates without any prior molecular data—opening up new possibilities for drug discovery.
KAIST (President Kwang Hyung Lee) announced on the 10th that a research team led by Professor Woo Youn Kim in the Department of Chemistry has developed an AI model named BInD (Bond and Interaction-generating Diffusion model), which can design and optimize drug candidate molecules tailored to a protein’s structure alone—without needing prior information about binding molecules. The model also predicts the binding mechanism (non-covalent interactions) between the drug and the target protein.
The core innovation of this technology lies in its “simultaneous design” approach. Previous AI models either focused on generating molecules or separately evaluating whether the generated molecule could bind to the target protein. In contrast, this new model considers the binding mechanism between the molecule and the protein during the generation process, enabling comprehensive design in one step. Since it pre-accounts for critical factors in protein-ligand binding, it has a much higher likelihood of generating effective and stable molecules. The generation process visually demonstrates how types and positions of atoms, covalent bonds, and interactions are created simultaneously to fit the protein’s binding site.
<Figure 1. Schematic of the diffusion model developed by the research team, which generates molecular structures and non-covalent interactions based on protein structures. Starting from a noise distribution, the model gradually removes noise (via reverse diffusion) to restore the atom positions, types, covalent bond types, and interaction types, thereby generating molecules. Interacting patterns are extracted from prior knowledge of known binding molecules or proteins, and through an inpainting technique, these patterns are kept fixed during the reverse diffusion process to guide the molecular generation.>
Moreover, this model is designed to meet multiple essential drug design criteria simultaneously—such as target binding affinity, drug-like properties, and structural stability. Traditional models often optimized for only one or two goals at the expense of others, but this new model balances various objectives, significantly enhancing its practical applicability.
The research team explained that the AI operates based on a “diffusion model”—a generative approach where a structure becomes increasingly refined from a random state. This is the same type of model used in AlphaFold 3, the 2024 Nobel Chemistry Prize-winning tool for protein-ligand structure generation, which has already demonstrated high efficiency.
Unlike AlphaFold 3, which provides spatial coordinates for atom positions, this study introduced a knowledge-based guide grounded in actual chemical laws—such as bond lengths and protein-ligand distances—enabling more chemically realistic structure generation.
<Figure 2. (Left) Target protein and the original bound molecule; (Right) Examples of molecules designed using the model developed in this study. The values for protein binding affinity (Vina), drug-likeness (QED), and synthetic accessibility (SA) are shown at the bottom.>
Additionally, the team applied an optimization strategy where outstanding binding patterns from prior results are reused. This allowed the model to generate even better drug candidates without additional training. Notably, the AI successfully produced molecules that selectively bind to the mutated residues of EGFR, a cancer-related target protein.
This study is also meaningful because it advances beyond the team’s previous research, which required prior input about the molecular conditions for the interaction pattern of protein binding.
Professor Woo Youn Kim commented that “the newly developed AI can learn and understand the key features required for strong binding to a target protein, and design optimal drug candidate molecules—even without any prior input. This could significantly shift the paradigm of drug development.” He added, “Since this technology generates molecular structures based on principles of chemical interactions, it is expected to enable faster and more reliable drug development.”
Joongwon Lee and Wonho Zhung, PhD students in the Department of Chemistry, participated as co-first authors of this study. The research results were published in the international journal Advanced Science (IF = 14.1) on July 11.
● Paper Title: BInD: Bond and Interaction-Generating Diffusion Model for Multi-Objective Structure-Based Drug Design
● DOI: 10.1002/advs.202502702
This research was supported by the National Research Foundation of Korea and the Ministry of Health and Welfare.
2025.08.12 View 5025 -
KAIST Develops Bioelectrosynthesis Platform for Switch-Like Precision Control of Cell Signaling
<(From left)Professor Jimin Park, Ph.D candidate Myeongeun Lee, Ph.D cadidate Jaewoong Lee,Professor Jihan Kim>
Cells use various signaling molecules to regulate the nervous, immune, and vascular systems. Among these, nitric oxide (NO) and ammonia (NH₃) play important roles, but their chemical instability and gaseous nature make them difficult to generate or control externally. A KAIST research team has developed a platform that generates specific signaling molecules in situ from a single precursor under an applied electrical signal, enabling switch-like, precise spatiotemporal control of cellular responses. This approach could provide a foundation for future medical technologies such as electroceuticals, electrogenetics, and personalized cell therapies.
KAIST (President Kwang Hyung Lee) announced on August 11 that a research team led by Professor Jimin Park from the Department of Chemical and Biomolecular Engineering, in collaboration with Professor Jihan Kim's group, has developed a 'Bioelectrosynthesis Platform' capable of producing either nitric oxide or ammonia on demand using only an electrical signal. The platform allows control over the timing, spatial range, and duration of cell responses.
Inspired by enzymes involved in nitrite reduction, the researchers implemented an electrochemical strategy that selectively produces nitric oxide or ammonia from a single precursor, nitrite (NO₂⁻). By changing the catalyst, the team generated ammonia or nitric oxide from nitrite using a copper-molybdenum-sulfur catalyst (Cu2MoS4) and an iron-incorporated catalyst (FeCuMS4), respectively.
Through electrochemical measurements and computer simulations, the team revealed that Fe sites in the FeCuMoS4 catalyst bind nitric oxide intermediates more strongly, shifting product selectivity toward nitric oxide. Under the same electrical conditions, the Fe-containing catalyst preferentially produces nitric oxide, whereas the Cu2MoS4 catalyst favors ammonia production.
<Figure 1. Schematic diagram of a bio-electrosynthesis platform that synthesizes a desired signaling substance with an electrical signal (left) and the results of precise cell control using it (right)>
The research team demonstrated biological functionality by using the platform to activate ion channels in human cells. Specifically, electrochemically produced nitric oxide activated TRPV1 channels (responsive to heat and chemical stimuli), while electrochemically produced ammonia induced intracellular alkalinization and activated OTOP1 proton channels. By tuning the applied voltage and electrolysis duration, the team modulated the onset time, spatial extent, and termination of cellular responses, which effectively turned cellular signaling on and off like a switch.
<Figure 2. Experimental results showing the change in the production ratio of nitric oxide and ammonia signaling substances according to the type of catalyst (left) and computational simulation results showing the strong bond between iron and nitric oxide (right)>
Professor Jimin Park said, "This work is significant because it enables precise cellular control by selectively producing signaling molecules with electricity. We believe it has strong potential for applications in electroceutical technologies targeting the nervous system or metabolic disorders."
Myeongeun Lee and Jaewoong Lee, Ph.D. students in the Department of Chemical and Biomolecular Engineering at KAIST, served as the co-first authors. Professor Jihan Kim is a co-author. The paper was published online in 'Angewandte Chemie International Edition' on July 8, 2025 (DOI: 10.1002/ange.202508192).
Reference: https://doi.org/10.1002/ange.202508192
Authors: Myeongeun Lee†, Jaewoong Lee†, Yongha Kim, Changho Lee, Sang Yeon Oh, Prof. Jihan Kim, Prof. Jimin Park*
†These authors contributed equally. *Corresponding author.
2025.08.12 View 3619 -
KAIST’s Wearable Robot Design Wins ‘2025 Red Dot Award Best of the Best’
<Professor Hyunjoon Park, M.S candidate Eun-ju Kang, Prospective M.S candidate Jae-seong Kim, undergraduate student Min-su Kim>
A team led by Professor Hyunjoon Park from the Department of Industrial Design won the ‘Best of the Best’ award at the 2025 Red Dot Design Awards, one of the world's top three design awards, for their 'Angel Robotics WSF1 VISION Concept.'
The design for the next-generation wearable robot for people with paraplegia successfully implements functionality, aesthetics, and social inclusion. This latest achievement follows the team's iF Design Award win for the WalkON Suit F1 prototype, which also won a gold medal at the Cybathlon last year. This marks consecutive wins at top-tier international design awards.
KAIST (President Kwang-hyung Lee) announced on the 8th of August that Move Lab, a research team led by Professor Hyunjoon Park from the Department of Industrial Design, won the 'Best of the Best' award in the Design Concept-Professional category at the prestigious '2025 Red Dot Design Awards' for their next-generation wearable robot design, the ‘Angel Robotics WSF1 VISION Concept.’
The German 'Red Dot Design Awards' is one of the world's most well-known design competitions. It is considered one of the world's top three design awards along with Germany’s iF Design Awards and America’s IDEA. The ‘Best of the Best’ award is given to the best design in a category and is awarded only to a very select few of the top designs (within the top 1%) among all Red Dot Award winners.
Professor Hyunjoon Park’s team was honored with the ‘Best of the Best’ award for a user-friendly follow-up development of the ‘WalkON Suit F1 prototype,’ which won a gold medal at the 2024 Cybathlon and an iF Design Award in 2025.
<Figure 1. WSF1 Vision Concept Main Image>
This award-winning design is the result of industry-academic cooperation with Angel Robotics Inc., founded by Professor Kyoungchul Kong from the KAIST Department of Mechanical Engineering. It is a concept design that proposes a next-generation wearable robot (an ultra-personal mobility device) that can be used by people with paraplegia in their daily lives.
The research team focused on transforming Angel Robotics Inc.'s advanced engineering platform into an intuitive and emotional, user-centric experience, implementing a design solution that simultaneously possesses functionality, aesthetics, and social inclusion.
<Figure 2. WSF1 Vision Concept Full Exterior (Front View)>
The WSF1 VISION Concept includes innovative features implemented in Professor Kyoungchul Kong’s Exo Lab, such as:
An autonomous access function where the robot finds the user on its own.
A front-loading mechanism designed for the user to put it on alone while seated.
Multi-directional walking functionality realized through 12 powerful torque actuators and the latest control algorithms.
AI vision technology, along with a multi-visual display system that provides navigation and omnidirectional vision.
This provides users with a safer and more convenient mobility experience.
The strong yet elegant silhouette was achieved through a design process that pursued perfection in proportion, surfaces, and details not seen in existing wearable robots. In particular, the fabric cover that wraps around the entire thigh from the robot's hip joint is a stylish element that respects the wearer's self-esteem and individuality, like fashionable athletic wear. It also acts as a device for the wearer to psychologically feel safe in interacting with the robot and blending in with the general public. This presents a new aesthetic for wearable robots where function and form are harmonized.
<Figure 3. WSF1 Vision Concept's Operating Principle. It walks autonomously and is worn from the front while the user is seated.>
KAIST Professor Hyunjoon Park said of the award, "We are focusing on using technology, aesthetics, and human-centered innovation to present advanced technical solutions as easy, enjoyable, and cool experiences for users. Based on Angel Robotics Inc.'s vision of 'recreating human ability with technology,' the WSF1 VISION Concept aimed to break away from the traditional framework of wearable robots and deliver a design experience that adds dignity, independence, and new style to the user's life."
<Figure 4. WSF1 Vision Concept Detail Image>
A physical model of the WSF1 VISION Concept is scheduled to be unveiled in the Future Hall of the 2025 Gwangju Design Biennale from August 30 to November 2. The theme is 'Po-yong-ji-deok' (the virtue of inclusion), and it will showcase the role of design language in creating an inclusive future society.
<Figure 5. WSF1 Vision Concept: Image of a Person Wearing and Walking>
2025.08.09 View 4913