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Prof. Lee"s Team Pioneers Biotechnological Production of Chemical Using Renewable Materials
A research team led by Prof. Sang-Yup Lee of the Bio and Brain Engineering Department at KAIST has succeeded in engineering the bacterium E. coli to produce the industrial chemical putrescine, university authorities said on Monday (Aug. 31). Putrescine, a four carbon chain diamine, is an important platform chemical with a wide range of applications for the pharmaceutical, agrochemical and chemical industries. It is currently used to synthesize nylon-4,6, a widely used engineering plastic. The research result, published in the Biotechnology and Bioengineering journal, proviDrdes a renewable alternative to the traditional process using fossil fuels. Currently the production of putrescine on an industrial scale relies on chemical synthesis, which requires non-renewable petrochemicals and expensive catalyst systems. This process is highly toxic and flammable with potentially severe repercussions for both the environment and human health. "For the first time we have developed a metabolically engineered E. coli strain that efficiently produces putrescine," said Professor Lee. "The development of a bio-refinery for chemicals and materials is very important in a world where dependency on fossil fuels is an increasing concern." The team developed a strain of E.coli capable of producing putrescine through metabolic engineering. This is where a cell"s metabolic and regulatory networks are enhanced in order to increase production of a needed material. First the team weakened or deleted competing metabolic pathways within the E. coli strain before deleting pathways which cause putrescine degradation. They also amplified the crucial enzyme Spec C, which converts the chemical ornithine into putrescine. Finally the putrescine exporter, which allows excretion of intracellularly made putrescine, was engineered while a global regulator was engineered to further increase the concentration of putrescine. The final result of this process was an engineered E.coli strain which produced 24.2 g of putrescine per litre. However, as it was believed that putrescine is toxic to microorganisms the team had to study putrescine tolerance in E.coli before it could be engineered to overproduce the chemical to the levels needed for industrial production. The results revealed that E. coli can tolerate at least 0.5 M of putrescine, which is tenfold higher than the usual concentration in the cell. This level of tolerance was an important surprise as it means that E. coli can be engineered to overproduce putrescine to industrially competitive levels. "The previously expected toxicity of putrescine may explain why its microbial production has been overlooked," said Lee. "Now a metabolically engineered E. coli strain has been developed which is capable of efficiently producing putrescine using renewable methods to an industrial level. This metabolic engineering framework should be useful for developing metabolically engineered microorganisms for the efficient production of other chemicals from renewable resources," he added.
2009.09.01
View 11028
Transparent Antenna for Automobile Developed
A research team led by Prof. Jae-Woo Park of the School of Electrical Engineering & Computer Science, KAIST, developed a transparent antenna for the next-generation automobiles, university authorities said on Monday (Aug. 17). The development was made possible through joint researches with the Hyundai-Kia Automotive Group; Winncom, a car antenna manufacturer; and a group of researchers led by Han-Ki Kim of the Department of Display Materials Engineering at Kyung Hee University in Seoul. The transparent antennas were developed in two kinds -- one for the HSDPA (High-Speed Downlink Packet Access), a new protocol for mobile telephone data transmission, and the other for transmitting and receiving radio wave for emergency call. Using the transparent electrically conductive film formation technology, the transparent antennas are to be mounted on the windshield of a vehicle. "The development of transparent antenna represents a step forward for the advancement of the next-generation automotive electronic technology," said Seong-woo Kim, a senior researcher at the Hyundai-Kia Group.
2009.08.18
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KAIST Professor Sang-Yup Lee Chair of International Metabolic Engineering Conference Due Next Year
KAIST distinguished professor Sang-Yup Lee was named to chair the 17th Metabolic Engineering Conference which will convene on Jeju Island, Korea, next year, under the theme of "Metabolic Engineering for Green Growth." It was decided at the 16th Biochemical Engineering Conference held in Burlington, Vermont, on July 5-9. Metabolic Engineering Conference in 2010 will not only involve presentations and discussions about metabolic engineering, but will inaugurate the “World Council on Industrial Biotechnology,” which will bring together global corporations and the world’s experts in industrial biochemical engineering, according to sources at KAIST. A KAIST official commented, “The fact that the Metabolic Engineering Conference is to be held here [in Korea] proves that Korea is being acknowledged as a key player in this field.” As the world faces the depletion of fossil fuels and environmental pollution, nations are showing increasing interest in industrial biochemical alternatives, such as microscopic organisms or new chemicals, to solve their problems. In addition, efficient production of biochemical materials and bio-fuels using microbes is deemed vital for the future. “The Korean government has become a model to other countries thanks to its leadership in carrying out the ‘Green Growth’ policy,” Professor Sang-Yup Lee said. He stated that KAIST is recognized for its research in advanced biochemical material and fuel production methods. “Green Growth,” a concept first developed by ESCAP, the UN agency working for social and economic cooperation in Asia and the Pacific, aims to achieve sustainable economic growth without destroying the environment. Ref. Department of Biochemical Engineering, Metabolic and BioMolecular Engineering Lab, KAIST
2009.07.17
View 11125
Prof. Choi Unveils Method to Improve Emission Efficiency of OLED
A KAIST research team led by Prof. Kyung-Cheol Choi of the School of Electrical Engineering & Computer Science discovered the surface plasmon-enhanced spontaneous emission based on an organic light-emitting device (OLED), a finding expected to improve OLED"s emission efficiency, KAIST authorities said on Thursday (July 9). For surface plasmon localization, silver nanoparticles were thermally deposited in a high vacuum on cathode. Since plasmons provide a strong oscillator decay channel, time-resolved photoluninescene (PL) results displayed a 1.75-fold increased emission rate, and continuous wave PL results showed a twofold enhanced intensity. "The method using surface plasmon represents a new technology to enhance the emission efficiency of OLED. It is expected to greatly contribute to the development of new technologies in OLED and flexible display, as well as securing original technology," Prof. Choi said. The finding was published in the April issue of Applied Physics Letters and the June 25 issue of Optics Express. It will be also featured as the research highlight of the August issue of Nature Photonics and Virtual Journal of Ultrafast Science.
2009.07.09
View 17363
KAIST to hold International Workshop on Flexible Displays
The 2009 KAIST International Workshop on Flexible Displays will take place at the Electrical Engineering Building on June 25, university sources said on Tuesday (June 23). The workshop organized by the Center for Advanced Flexible Display Convergence (CAFDC) will explore the status and future vision of flexible and transparent plasma displays, which are among the key technologies for the development of the next-generation displays. There will be also discussions about technologies to realize the large-scale flexible and transparent display which is regarded as the display of the future. Among the speakers are some of the most prominent figures in the field. Gary Eden from University of Illinois, Prof. Kunihide Tachibana from Kyoto University, and Carol Wedding, the president of Imaging Systems Tech., USA and several other well-known professors and engineers will participate in the workshop. Professor Kyung-Cheol Choi, CAFDC chair, said: "The workshop will provide an excellent opportunity to examine the flexible and transparent plasma display technologies. It will also be a good chance to explore large-scale flexible and transparent displays from various technical viewpoints."
2009.06.24
View 14165
Prof. Sang-Ouk Kim Featured on the Cover of Emerging Investigator Special Issue
KAIST Prof. Sang-Ouk Kim of the Department of Materials Science and Engineering was featured on the cover of the Emerging Investigator Special Issue published by Britain"s Royal Society of Chemistry on June 21, university authorities said on Monday (June 22). The special issue shed spotlight on 18 up-and-coming scientists who have been selected through the recommendation and rigorous screening process of the editorial and advisory boards of the Royal Society of Chemistry. The 18 scientists consist of six from the American continent, 10 from Europe, one from Japan and one from Korea. The journal introduced Prof. Kim"s paper, titled "Highly entangled carbon nanotube (CNT) scaffolds by self-organized aqueous droplets." Kim explained in the paper that the cellular CNT demonstrated high electrical conductivity and field-emission properties, which is potentially useful for various applications in electronics and energy storage devices.
2009.06.24
View 10529
KAIST Dedicates Geocentrifuge Experiment Center
KAIST dedicated the KOCED Geo-Centrifuge Experiment Center for researches in monitoring natural disasters such as earthquake and embankment collapse through miniature simulation tests on Wednesday (April 9) after a two-year construction work. The experiment center is part of the Korea Construction Engineering Development Collaboratory Program (KOCED) which has been sponsored by the Ministry of Land, Transport and Maritime Affairs to build an infrastructure for construction engineering researches at a national level. The ministry plans to build a total of 5 similar centers nationwide by the end of the year. On hand at the dedication ceremony were Jae-Choon Lee, President of the Korea Institute of Construction & Transportation Technology Evaluation and Planning, KAIST President Nam-Pyo Suh, and scores of experts and administration officials. The construction of the five-story building on an area of about 3,328 square meters cost 8.4 billion won (US$6.3 million). The center is expected to serve as a major laboratory in the field of geotechnical engineering. It is equipped with such state-of-the-art facilities as geocentrifuge, a useful tool for studying flow in unsaturated soil under well-controlled, repeatable conditions, a bidirectional shaking-table that can reproduce earthquake-like wave; and robots that can reproduce construction procedures by remote control. Geocentrifuge experiment allows detecting ground and structure motions easily and rapidly by simulation tests. Thus, it is widely used for various geotechnical engineering researches such as evaluation of seismic safety, soft ground movement, slope stability analysis, etc. The causes of the embankment collapse in New Orleans by Hurricane Katrina in 2005 were also revealed by the geocentrifuge experiment. The geocentrifuge research facility is available for use by outside researchers, so scientists from other universities, research institutes and corporations can perform research and test their scientific and engineering hypotheses. The center is divided into two sections, experiment building and research building. The experiment building is composed of a geocentrifuge laboratory, model-making rooms, workshops, a geotechnical engineering laboratory and specimen storehouse, while the research building has a control room, a video conference room, an electronic library and research rooms.
2009.04.09
View 10677
KAIST Research Team Discovers Process for Rapid Growth of N-Doped CNT Arrays
A team of scientists led by Profs. Sang-Ouk Kim, Won-Jong Lee and Duck-Hyun Lee of the Department of Materials Science and Engineering has found a straightforward process for rapid growth of wall-number selected, nitrogen-doped carbon nanotube (CNT) arrays, university officials said on Monday (March 16). KAIST researchers prepared highly uniform nanopatterned iron catalyst arrays by tilted deposition through block copolymer nanotemplates. This remarkably fast growth of highly uniform N-doped CNTs, whose material properties and chemical functionalizability are reinforced by N-doping, offers a new area of a large-scale nanofabrication, potentially useful for diverse nano-devices. Carbon nanotubes (CNTs) are of broad technical interest in electronics, photonics, energy devices, and other applications. However, establishing a straightforward process for mass production of uniform CNTs with desired structure and properties has been a long-standing challenge. In particular, it was strongly desired to precisely control the numbers of walls and diameter of CNTs, which are decisive parameters for the physical properties of CNTs. In this respect, the preparation of monodisperse catalyst array having a narrow size distribution is generally considered an effective pathway to produce well-defined CNTs, since the number of walls and diameter of the produced CNTs are closely related to the catalyst size. The finding was featured in the March 13 edition of Nano Letters, a leading journal in the nano technology field.
2009.03.20
View 11682
Six Organizations Join Forces to Induce Projected National Brain Institute to Daejeon
Six major organizations including KAIST have joined forces to help Daejeon City to win the government approval to build the envisioned Korean Brain Institute in Daedeok Research Complex. The six organizations signed a memorandum of understanding on cooperating in establishing the government-funded institute built within the Daedeok Research Complex in the city of Daejeon, at KAIST on Jan. 14. The six organizations are KAIST, the Daejeon City Government, Korea Research Institute of Bioscience and Biotechnology, Korea Research Institute of Standard and Science, Asan Medical Center, and SK Corp., a pioneer in effective therapeutic invention for serious brain disorders. The partnership of the six organizations is expected to bring a broad-based cooperation opportunities and create a massive synergy effect in the brain science researches and the development of new therapeutic treatment for brain disorders by combining their resources and infrastructures. The six organizations have also built an international research network with such globally-renowned brain research institutions as RIKEN, a large natural sciences research institute in Japan, Max Plank Institute in Germany, Federal Institute of Technology, Lausanne, in Switzerland and Brain Research Institute of University of Queensland in Australia. The research network is under the support and guidance of Dennis Choi, a prominent neuroscientist who once served as the President of the Society for Neuroscience and is currently a professor in the Departments of Neurology and biology at Emory University. The tentatively titled Korea Brain Institute is envisioned to help fight brain disorders and create Korea"s new growth engine, as well as lengthening life span, by conducting convergence researches in nero science, brain science and pharmacology. If the consortium of the six organizations wins the government approval to build the proposed institute within the Daedeok complex, the central government and the Daejeon city government are expected to pour a total of 329.7 billion won into the project by 2020.
2009.01.14
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2008 IEEE International Conference on Humanoid Robots Opens
The 2008 IEEE-RAS International Conference on Humanoid Robots, an international gathering to identify new research trends and technology in humanoid robotics, will open a three-day session on Monday (Dec. 1) at the Hotel Rivera and KAIST in Daejeon. The annual conference is organized by KAIST and the Robotics and Automation Society of the Institute for Electric and Electronic Engineers, a U.S.-based international non-profit, professional organization for the advancement of technology related to electricity. The conference is expected to draw a total of 200 robotics researchers from 19 different countries. Prof. Jun-Ho Oh, at the Department of Mechanical Engineering who led the creation of Korea"s first humanoid robot Hubo, is serving as general chair of the conference. Prof. Oh was named the host of the 2008 conference at the 2007 conference held at the Carnegie Melon University of the United States. The eight-year old conference was inaugurated in Boston in 2000. On the opening day of Dec. 1, seven lectures will be given on diverse areas of robotics including cognitive humanoid vision, and robot vision sensor and sensing. On the subsequent two days, a total of 110 papers will be presented. During the conference period, a variety of robots produced by six local and foreign robot makers will be on demonstration, providing opportunities for researchers and industrial robot makers to share technological ideas. Highlights of the conference will be special lectures by world-renowned robot researchers Prof. Yoshiyuki Sankai of University of Tsukuba, who has created an exoskeletal "robot suit," and Prof. Art Kuo of Univerity of Michigan who is regarded as a leading authority in dynamic walking. Following the conference, all participants are scheduled to tour Prof. Oh"s Hubo Lab and the Human-Robot Interaction Research Center, both located at KAIST.
2008.12.01
View 11165
KAIST Collaborating with U.S. Universities to Advance Humanoid Robotics
Hubo, a life-size walking bipedal humanoid robot, is perhaps the best-known character in Korea that KAIST has ever produced. It was shown to the government heads of the Asia-Pacific region during the APEC held in Busan, Korea, in 2005 and appeared at the hit concerts of the pop singer Jang-Hoon Kim. The humanoid robot is soon likely to catch the fancy of Americans as a U.S. government-funded project seeks to create a Hubo that can work and interact with people in collaboration with Korean scientists. "We are going to give the brains to Hubo. (Japanese) Asimo can do only pre-programmed actions. We want to create a Hubo that can help people, interact with people," said Prof. Paul Oh of the Department of Mechanical Engineering & Mechanics at Drexel University in Philadelphia and leader of the five-year international project which was launched in November 2007. The U.S.$2.5 million project is funded through the Partnership for International Research and Education (PIRE) Program of the National Science Foundation (NSF) of the United States. It brings together world-renowned experts in humanoid design and information technologies. "Dr. Jun-Ho Oh"s lab at KAIST (that has created Hubo) is the world"s leader in humanoid design and the U.S. has advanced technologies in the areas such as artificial intelligence, mechanical learning and robot vision. Combining the strengths of the two countries can create a synergy effect and develop a more advanced humanoid robot," said Paul Oh. He is currently serving as Program Director of Robotics of the NSF which is overseeing robotics research (non-military) in the U.S. consisting over 150 robotics faculty. Paul Oh"s research team consists of experts from five U.S. universities -- Drexel, Bryn Mawr College, Colby College, the University of Pennsylvania and Virginia Tech -- and KAIST. Leading a delegation of six professors and eight students, Dr. Paul Oh made a two-day visit to KAIST on Nov. 18-19 to review the progress of the project and have a technical meeting with participants. "The U.S. universities participating in this program are scattered across the nation. So we decided to have a technical meeting here in Korea," he said. Asked the reason why he chose KAIST as a partner for the program, Dr. Oh said that KAIST is willing to open Hugo to international researchers, whereas in Japan only Honda engineers are allowed to touch Asimo, which is a humanoid robot created by Honda Motor Company. The project is to establish no barrier for roboticists anywhere in the world to pursue the humanoid research; a suite of humanoid platforms will be available for researchers to develop and advance capabilities like locomotion and human-robot interaction. The team has been initially involved in development of three tools, all of which are based on the Hubo platform, in order to kick-start humanoid research in the U.S. They are the Mini-Hubo (a small, light-weight and affordable humanoid purchasable at the price lower than $8,000), On-Line Hubo (a program to operate Hubo online) and Virtual Hubo (a simulation program to do researches in cyberspace). As the first outcome of the project, the Mini-Hubo is expected to be released in the U.S. around next April. Another important purpose of the PIRE program is to seek transformative models to train scientists and engineers to effectively work in global multi-disciplined design teams. To this end, an aggregate number of 20 students from U.S. universities are to stay at the KAIST during the next five years, with two students taking turns on a six-month term. "I was really amazed how much work is done with small funding here. This is really an excellent example to learn," said Roy Gross, an undergraduate from Drexel who has been staying at Prof. Oh"s Lab for the past three months.
2008.11.21
View 14070
KAIST Research Team Unveils Method to Fabricate Photonic Janus Balls
A research team led by Prof. Seung-Man Yang of the Department of Chemical and Biomolecular Engineering has found a method to fabricate photonic Janus balls with isotropic structural colors. The finding draws attention since the newly-fabricated photonic balls may prove useful pigments for the realization of e-paper or flexible electronic displays. The breakthrough was published in the Nov. 3 edition of the science journal "Advanced Materials." The Nov. 6 issue of "Nature" also featured it as one of the research highlights under the title of "Future Pixels." Prof. Yang"s research team found that tiny marbles, black on one side and colored on the other, can be made by "curing" suspensions of silica particles with an ultraviolet lamp. When an electric field is applied, the marbles line up so that the black sides all face upwards, which suggests they may prove useful pigments for flexible electronic displays. The researchers suspended a flow of carbon-black particles mixed with silica and a transparent or colored silica flow in a resin that polymerizes under ultraviolet light. They then passed the mixture through a tiny see-through tube. The light solidified the silica and resin as balls with differently colored regions, each about 200 micrometers in diameter. Over the last decades, the development of industrial platforms to artificially fabricate structural color pigments has been a pressing issue in the research areas of materials science and optics. Prof. Yang, who is also the director of the National Creative Research Initiative Center for Integrated Optofluidic Systems, has led the researches focused on fabrication of functional nano-materials through the process of assembling nano-building blocks into designed patterns. The "complementary hybridization of optical and fluidic devices for integrated optofluidic systems" research was supported by a grant from the Creative Research Initiative Program of the Ministry of Education, Science & Technology.
2008.11.12
View 11114
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