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An Improved Carbon Nanotube Semiconductor
Professor Yang-Kyu Choi and his research team of the School of Electrical Engineering at KAIST collaborated with Professor Sung-Jin Choi of Kookmin University to develop a large-scale carbon nanotube semiconductor by using a 3-D fin-gate structure with carbon nanotubes on its top. Dong Il Lee, a postdoctoral researcher at KAIST’s Electrical Engineering School, participated in this study as the first author. It was published in ACS Nano on November 10, 2016, and was entitled “Three-Dimensional Fin-Structured Semiconducting Carbon Nanotube Network Transistor.” A semiconductor made with carbon nanotubes operates faster than a silicon semiconductor and requires less energy, yielding higher performance. Most electronic equipment and devices, however, use silicon semiconductors because it is difficult to fabricate highly purified and densely packed semiconductors with carbon nanotubes (CNTs). To date, the performance of CNTs was limited due to their low density. Their purity was also low, so it was impossible to make products that had a constant yield on a large-surface wafer or substrate. These characteristics made the mass production of semiconducting CNTs difficult. To solve these difficulties, the research team used a 3-D fin-gate to vapor-deposit carbon nanotubes on its top. They developed a semiconductor that had a high current density with a width less than 50 nm. The three-dimensional fin structure was able to vapor-deposit 600 carbon nanotubes per micrometer. This structure could have 20 times more nanotubes than the two dimensional structure, which could only vapor-deposit thirty in the same 1 micrometer width. In addition, the research team used semi-conductive carbon nanotubes having a purity rating higher than 99.9% from a previous study to obtain a high yield semiconductor. The semiconductor from the research group has a high current density even with a width less than 50 μm. The new semiconductor is expected to be five times faster than a silicon-based semiconductor and will require five times less electricity during operation. Furthermore, the new semiconductor can be made by or will be compatible with the equipment for producing silicon-based semiconductors, so there will be no additional costs. Researcher Lee said, “As a next generation semiconductor, the carbon nanotube semiconductor will have better performance, and its effectiveness will be higher.” He also added, “Hopefully, the new semiconductor will replace the silicon-based semiconductors in ten years.” This study received support from the Center for Integrated Smart Sensors funded by the Ministry of Science, ICT & Future Planning of Korea as the Global Frontier Project, and from the CMOS (Complementary Metal-Oxide-Semiconductor) THz Technology Convergence Center of the Pioneer Research Center Program sponsored by the National Research Foundation of Korea. Picture 1: 3D Diagram of the Carbon Nanotube Electronic Device and Its Scanning Electron Microscope (SEM) Image Picture 2: 3D Transistor Device on an 8-inch Base and the SEM Image of Its Cross Section
2017.02.16
View 8142
A New Approach to 3D Holographic Displays Greatly Improves the Image Quality
With the addition of holographic diffusers or frosted glasses to wavefront modulators, KAIST researchers offer a simple and practical solution to significantly enhance the performance of 3D dynamic holographic displays by 2,600 times. The potential applications of three-dimensional (3D) digital holograms are enormous. In addition to arts and entertainment, various fields including biomedical imaging, scientific visualization, engineering design, and displays could benefit from this technology. For example, creating full-sized organs for 3D analysis by doctors could be helpful, but it remained a challenge owing to the limitation of hologram-generation techniques. A research team led by Professor YongKeun Park of the Physics Department at KAIST has come up with a solution and developed a 3D holographic display that performs more than 2,600 times better than existing 3D holographic displays. This study is expected to improve the limited size and viewing angle of 3D images, which were a major problem of the current holographic displays. The study was published online in Nature Photonics on January 23, 2017. 3D holograms, which often appear in science fiction films, are a familiar technology to the public, but holograms in movies are created with computer graphic effects. Methods for creating true 3D holograms are still being studied in the laboratory. For example, due to the difficulty of generating real 3D images, recent virtual reality (VR) and augmented reality (AR) devices project two different two-dimensional (2D) images onto a viewer to induce optical illusions. To create a 3D hologram that can be viewed without special equipment such as 3D glasses, the wavefront of light must be controlled using wavefront modulators such as spatial light modulators (SLMs) and deformable mirrors (DMs). A wavefront modulator is an optical manipulation device that can control the direction of light propagation. However, the biggest limitation to using these modulators as 3D displays is the number of pixels. The large number of pixels that are packed into high-resolution displays developed in recent years are suitable for a 2D image, and the amount of information contained in those pixels cannot produce a 3D image. For this reason, a 3D image that can be made with existing wavefront modulator technology is 1 cm in size with a narrow viewing angle of 3 degrees, which is far from practicable. As an alternative, KAIST researchers used a DM and added two successive holographic diffusers to scatter light. By scattering light in many directions, this allows for a wider viewing angle and larger image, but results in volume speckle fields, which are caused by the interference of multiple scattered light. Random volume speckle fields cannot be used to display 3D images. To fix the problem, the researchers employed a wavefront-shaping technique to control the fields. As a result, they succeeded in producing an enhanced 3D holographic image with a viewing angle of 35 degrees in a volume of 2 cm in length, width, and height. This yielded a performance that was about 2,600 times stronger than the original image definition generated when they used a DM without a diffuser. Professor Park said, “Scattering light has previously been believed to interfere with the recognition of objects, but we have demonstrated that current 3D displays can be improved significantly with an increased viewing angle and image size by properly controlling the scattered light.” Hyeonseung Yu, who is the lead author of this research article and a doctoral candidate in the Department of Physics, KAIST, noted that this technology signals a good start to develop a practical model for dynamic 3D hologram displays that can be enjoyed without the need for special eyeglasses. “This approach can also be applied to AR and VR technology to enhance the image resolution and viewing angles,” added Yu. The research paper is entitled “Ultrahigh-definition Dynamic 3D Holographic Display by Active Control of Volume Speckle Fields.” Figure 1. Concept of Scattering Display The size and viewing angle of 3D images can be simultaneously increased when a scattering medium (diffuser) is introduced. By controlling the wavefront impinging on the scattering medium, the desired 3D hologram is generated. Figure 2. Experimental Setup The optical set-up consists of a deformable mirror and the scattering medium with two successive holographic diffusers. A high-numerical-aperture imaging unit mounted on a three-axis motorized translational system is utilized for wavefront optimization and imaging. Figure 3. 3D Images Projected This picture shows 3D images in a volume of 2 cm × 2 cm × 2 cm with a viewing angle of 35 degrees using one of the wavefront modulators, a digital micromirror device (DMD). Figure 4. Artist’s Rendition of the Proposed Concept A dynamic 3D hologram of a face is displayed.
2017.02.01
View 11717
Professor Dongman Lee Wins the 2016 Korea Internet Award
Professor Dongman Lee of KAIST’s School of Computing received the 11th Korea Internet Award in the category of personal achievement on December 13 at the Creative Economy and Innovation Center in Gyeonggi province. Hosted by the Ministry of Science, ICT and Future Planning of Korea, the Internet Award recognizes leaders in the Internet industry and their contributions. Since 2010, Professor Lee has conducted research on the Internet of Things (IoT) platforms, resulting in the publication of five research papers in Science Citation Index (SCI) journals, ten papers in Korean journals, 30 best papers nominations at international conferences, and the registration of eleven patents. He has also worked on the creation of an IoT ecosystem through his research on object interworking platforms that can provide diverse user-customized services in the IoT environment. His research team built a test bed for applicable IoT platforms on the 8th floor of the IT Convergence Center on campus to implement experiments and collect various data, thereby creating a foundation to carry out research projects in this field. Professor Lee has helped the advancement of an Internet governance system in Korea by researching Internet governance policies, holding important posts in related academic societies including the Chairman of the Korea Internet Governance Alliance (KIGA) Council, and hosting major conferences such as the Asia Pacific Regional Internet Governance Forum (APrIGF).
2016.12.20
View 5773
Professor Kwon to Represent the Asia-Pacific Region of the IEEE RAS
Professor Dong-Soon Kwon of the Mechanical Engineering Department at KAIST has been reappointed to the Administrative Committee of the Institute of Electrical and Electronics Engineers (IEEE) Robotics and Automation Society (IEEE RAS). Beginning January 1, 2017, he will serve his second three-year term, which will end in 2019. In 2014, he was the first Korean appointed to the committee, representing the Asia-Pacific community of the IEEE Society. Professor Kwon said, “I feel thankful but, at the same time, it is a great responsibility to serve the Asian research community within the Society. I hope I can contribute to the development of robotics engineering in the region and in Korea as well.” Consisted of 18 elected members, the administrative committee manages the major activities of IEEE RAS including hosting its annual flagship meeting, the International Conference on Robotics and Automation. The IEEE RAS fosters the advancement in the theory and practice of robotics and automation engineering and facilitates the exchange of scientific and technological knowledge that supports the maintenance of high professional standards among its members.
2016.12.06
View 6262
Mystery of Biological Plastic Synthesis Machinery Unveiled
Plastics and other polymers are used every day. These polymers are mostly made from fossil resources by refining petrochemicals. On the other hand, many microorganisms naturally synthesize polyesters known as polyhydroxyalkanoates (PHAs) as distinct granules inside cells. PHAs are a family of microbial polyesters that have attracted much attention as biodegradable and biocompatible plastics and elastomers that can substitute petrochemical counterparts. There have been numerous papers and patents on gene cloning and metabolic engineering of PHA biosynthetic machineries, biochemical studies, and production of PHAs; simple Google search with “polyhydroxyalkanoates” yielded returns of 223,000 document pages. PHAs have always been considered amazing examples of biological polymer synthesis. It is astounding to see PHAs of 500 kDa to sometimes as high as 10,000 kDa can be synthesized in vivo by PHA synthase, the key polymerizing enzyme in PHA biosynthesis. They have attracted great interest in determining the crystal structure of PHA synthase over the last 30 years, but unfortunately without success. Thus, the characteristics and molecular mechanisms of PHA synthase were under a dark veil. In two papers published back-to-back in Biotechnology Journal online on November 30, 2016, a Korean research team led by Professor Kyung-Jin Kim at Kyungpook National University and Distinguished Professor Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) described the crystal structure of PHA synthase from Ralstonia eutropha, the best studied bacterium for PHA production, and reported the structural basis for the detailed molecular mechanisms of PHA biosynthesis. The crystal structure has been deposited to Protein Data Bank in February 2016. After deciphering the crystal structure of the catalytic domain of PHA synthase, in addition to other structural studies on whole enzyme and related proteins, the research team also performed experiments to elucidate the mechanisms of the enzyme reaction, validating detailed structures, enzyme engineering, and also N-terminal domain studies among others. Through several biochemical studies based on crystal structure, the authors show that PHA synthase exists as a dimer and is divided into two distinct domains, the N-terminal domain (RePhaC1ND) and the C-terminal domain (RePhaC1CD). The RePhaC1CD catalyzes the polymerization reaction via a non-processive ping-pong mechanism using a Cys-His-Asp catalytic triad. The two catalytic sites of the RePhaC1CD dimer are positioned 33.4 Å apart, suggesting that the polymerization reaction occurs independently at each site. This study also presents the structure-based mechanisms for substrate specificities of various PHA synthases from different classes. Professor Sang Yup Lee, who has worked on this topic for more than 20 years, said, “The results and information presented in these two papers have long been awaited not only in the PHA community, but also metabolic engineering, bacteriology/microbiology, and in general biological sciences communities. The structural information on PHA synthase together with the recently deciphered reaction mechanisms will be valuable for understanding the detailed mechanisms of biosynthesizing this important energy/redox storage material, and also for the rational engineering of PHA synthases to produce designer bioplastics from various monomers more efficiently.” Indeed, these two papers published in Biotechnology Journal finally reveal the 30-year mystery of machinery of biological polyester synthesis, and will serve as the essential compass in creating designer and more efficient bioplastic machineries. References: Jieun Kim, Yeo-Jin Kim, So Young Choi, Sang Yup Lee and Kyung-Jin Kim. “Crystal structure of Ralstonia eutropha polyhydroxyalkanoate synthase C-terminal domain and reaction mechanisms” Biotechnology Journal DOI: 10.1002/biot.201600648 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600648/abstract Yeo-Jin Kim, So Young Choi, Jieun Kim, Kyeong Sik Jin, Sang Yup Lee and Kyung-Jin Kim. “Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme” Biotechnology Journal DOI: 10.1002/biot.201600649 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600649/abstract
2016.12.02
View 7769
KAIST's Doctoral Student Receives a Hoffman Scholarship Award
Hyo-Sun Lee, a doctoral student at the Graduate School of EEWS (Environment, Energy, Water and Sustainability), KAIST, is a recipient of the 2016 Dorothy M. and Earl S. Hoffman Scholarships presented by the American Vacuum Society (AVS). The award ceremony took place during the Society’s 63rd International Symposium and Exhibition on November 6-11, 2016 in Nashville, Tennessee. Lee is the first Korean and foreign student to receive this scholarship. The Hoffman Scholarships were established in 2002 to recognize and encourage excellence in graduate studies in the sciences and technologies of interest to AVS. The scholarships are funded by a bequest from Dorothy M. Hoffman, who was a pioneering member of the Society of Women Engineers and served as the president of AVS in 1974. Lee received the scholarship for her research that detects hot electrons from chemical reactions on catalytic surface using nanodevices. Nano Letters, an academic journal published by the American Chemical Society, described her work in its February 2016 issue as a technology that allows quantitative analysis of hot electrons by employing a new nanodevice and therefore helps researchers understand better the mechanism of chemical reactions on nanocatalytic surface. She also published her work to detect the flow of hot electrons that occur on metal nanocatalytic surface during hydrogen oxidation reactions in Angewandte Chemie. Lee said, “I am pleased to receive this honor from such a world-renowned academic society. Certainly, this will be a great support for my future study and research.” Founded in 1953, AVS is an interdisciplinary, professional society composed of approximately 4,500 members worldwide. It supports networking among academic, industrial, government, and consulting professionals involved in a range of established and emerging science and technology areas such as chemistry, physics, engineering, business, and technology development.
2016.11.17
View 6394
Professor Lee Co-chairs the Global Future Councils on Biotechnology of the WEF
The World Economic Forum (WEF) established a new global network of the world’s leading experts, “The Annual Meeting of the Global Future Councils,” to explore innovative solutions for the most pressing global challenges. The Councils’ first meeting took place on November 13-14, 2016, in Dubai, the United Arab Emirates (UAE). Some 25 nations joined as member states. The Councils have 35 committees. Over 700 global leaders in business, government, civil society and academia gathered at the inaugural meeting to “develop ideas and strategies to prepare the world for the Fourth Industrial Revolution, with topics including smart cities, robotics, and the future of mobility,” according to a statement issued by the WEF. Distinguished Professor Sang Yup Lee of Chemical and Biomolecular Engineering at KAIST was appointed to co-chair one of the Councils' committees, The Annual Meeting of the Global Future Councils on Biotechnology, for two years. The other chairperson is Dr. Feng Zhang, a professor of Biomedical Engineering at the Massachusetts Institute of Technology (MIT), who played a critical role in the development of optogenetics and CRISPR technologies. The Biotechnology Committee consists of 24 globally recognized professionals in life sciences, law, ethics and policy including Thomas Connelly, the executive director of the American Chemical Society, Tina Fano, the executive vice president of Novozymes, and Mostafa Ronaghi, the chief technology officer of Illumina. Professor Lee also serves as a committee member of The Annual Meeting of the Global Future Councils on the Fourth Industrial Revolution. “Life sciences and engineering will receive more attention as a key element of the Fourth Industrial Revolution that the global society as a whole has been experiencing now. Together with thought leaders gathered worldwide, I will join the international community’s concerted efforts to address issues of importance that impact greatly on the future of humanity,” Professor Lee said. In addition, Professor Lee received the James E. Bailey Award 2016 from The Society for Biological Engineering on November 15, 2016. He is the first Asian researcher to be recognized for his contributions to the field of biotechnology.
2016.11.15
View 6452
Doctoral Student Receives the Best Paper Award from the International Metabolic Engineering Conference 2016
So Young Choi, a Ph.D. candidate at the Department of Chemical and Biomolecular Engineering at KAIST, received the Student and Young Investigator Poster Award at the 11th International Metabolic Engineering Conference held in Awaji, Japan on June 26-30. Choi received the award for her research on one-step fermentative production of Poly(lactate-co-glycolate) (PLGA) from carbohydrates in Escherichia coli, which was published in the April 2016 issue of Nature Biotechnology. In her paper, she presented a novel technology to synthesize PLGA, a non-natural copolymer, through a biological production process. Because of its biodegradability, non-toxicity, and biocompatibility, PLGA is widely used in biomedical and therapeutic applications, including surgical sutures, prosthetic devices, drug delivery, and tissue engineering. Employing a metabolic engineering approach, Choi manipulated the metabolic pathway of an Escherichia coli bacterium to convert glucose and xylose into the biosynthesis of PLGA within the cell. Previously, PLGA could be obtained only through chemical synthesis. Choi said, “I’m thrilled to receive an award from a flagship conference of my research field. Mindful of this recognition, I will continue my research to produce meaningful results, thereby contributing to the development of science and technology in Korea.” The International Metabolic Engineering Conference is a leading professional gathering where state-of-the-art developments and achievements made in the field of metabolic engineering are shared. With the participation of about 400 professionals from all around the world, the conference participants discussed this year’s theme of “Design, Synthesis and System Integration for Metabolic Engineering.”
2016.07.07
View 8925
KAIST, NTU, and Technion Collaborate for Research in Emerging Fields
KAIST, Nanyang Technological University (NTU) of Singapore, and Technion of Israel signed an agreement on April 11, 2016 in Seoul to create a five-year joint research program for some of the most innovative and entrepreneurial areas: robotics, medical technologies, satellites, materials science and engineering, and entrepreneurship. Under the agreement, the universities will also offer dual degree opportunities, exchange visits, and internships. In the picture from the left, Bertil Andersson of NTU, Sung-Mo Kang of KAIST, and Peretz Lavie of Technion hold the signed memorandum of understanding.
2016.04.14
View 7859
Non-Natural Biomedical Polymers Produced from Microorganisms
KAIST researchers have developed metabolically engineered Escherichia coli strains to synthesize non-natural, biomedically important polymers including poly(lactate-co-glycolate) (PLGA), previously considered impossible to obtain from biobased materials. Renewable non-food biomass could potentially replace petrochemical raw materials to produce energy sources, useful chemicals, or a vast array of petroleum-based end products such as plastics, lubricants, paints, fertilizers, and vitamin capsules. In recent years, biorefineries which transform non-edible biomass into fuel, heat, power, chemicals, and materials have received a great deal of attention as a sustainable alternative to decreasing the reliance on fossil fuels. A research team headed by Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at KAIST has established a biorefinery system to create non-natural polymers from natural sources, allowing various plastics to be made in an environmentally-friendly and sustainable manner. The research results were published online in Nature Biotechnology on March 7, 2016. The print version will be issued in April 2016. The research team adopted a systems metabolic engineering approach to develop a microorganism that can produce diverse non-natural, biomedically important polymers and succeeded in synthesizing poly(lactate-co-glycolate) (PLGA), a copolymer of two different polymer monomers, lactic and glycolic acid. PLGA is biodegradable, biocompatible, and non-toxic, and has been widely used in biomedical and therapeutic applications such as surgical sutures, prosthetic devices, drug delivery, and tissue engineering. Inspired by the biosynthesis process for polyhydroxyalkanoates (PHAs), biologically-derived polyesters produced in nature by the bacterial fermentation of sugar or lipids, the research team designed a metabolic pathway for the biosynthesis of PLGA through microbial fermentation directly from carbohydrates in Escherichia coli (E. coli) strains. The team had previously reported a recombinant E. coli producing PLGA by using the glyoxylate shunt pathway for the generation of glycolate from glucose, which was disclosed in their patents KR10-1575585-0000 (filing date of March 11, 2011), US08883463 and JP5820363. However, they discovered that the polymer content and glycolate fraction of PLGA could not be significantly enhanced via further engineering techniques. Thus, in this research, the team introduced a heterologous pathway to produce glycolate from xylose and succeeded in developing the recombinant E. coli producing PLGA and various novel copolymers much more efficiently. In order to produce PLGA by microbial fermentation directly from carbohydrates, the team incorporated external and engineered enzymes as catalysts to co-polymerize PLGA while establishing a few additional metabolic pathways for the biosynthesis to produce a range of different non-natural polymers, some for the first time. This bio-based synthetic process for PLGA and other polymers could substitute for the existing complicated chemical production that involves the preparation and purification of precursors, chemical polymerization processes, and the elimination of metal catalysts. Professor Lee and his team performed in silico genome-scale metabolic simulations of the E. coli cell to predict and analyze changes in the metabolic fluxes of cells which were caused by the introduction of external metabolic pathways. Based on these results, genes are manipulated to optimize metabolic fluxes by eliminating the genes responsible for byproducts formation and enhancing the expression levels of certain genes, thereby achieving the effective production of target polymers as well as stimulating cell growth. The team utilized the structural basis of broad substrate specificity of the key synthesizing enzyme, PHA synthase, to incorporate various co-monomers with main and side chains of different lengths. These monomers were produced inside the cell by metabolic engineering, and then copolymerized to improve the material properties of PLGA. As a result, a variety of PLGA copolymers with different monomer compositions such as the US Food and Drug Administration (FDA)-approved monomers, 3-hydroxyburate, 4-hydroxyburate, and 6-hydroxyhexanoate, were produced. Newly applied bioplastics such as 5-hydroxyvalerate and 2-hydroxyisovalerate were also made. The team employed a systems metabolic engineering application which, according to the researchers, is the first successful example of biological production of PGLA and several novel copolymers from renewable biomass by one-step direct fermentation of metabolically engineered E.coli. Professor Lee said, “We presented important findings that non-natural polymers, such as PLGA which is commonly used for drug delivery or biomedical devices, were produced by a metabolically engineered gut bacterium. Our research is meaningful in that it proposes a platform strategy in metabolic engineering, which can be further utilized in the development of numerous non-natural, useful polymers.” Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning of Korea, who oversees the Technology Development Program to Solve Climate Change, said, “Professor Lee has led one of our research projects, the Systems Metabolic Engineering for Biorefineries, which began as part of the Ministry’s Technology Development Program to Solve Climate Change. He and his team have continuously achieved promising results and been attracting greater interest from the global scientific community. As climate change technology grows more important, this research on the biological production of non-natural, high value polymers will have a great impact on science and industry.” The title of the research paper is “One-step Fermentative Production of Poly(lactate-co-glycolate) from Carbohydrates in Escherichia coli (DOI: 10.1038/nbt.3485).” The lead authors are So Young Choi, a Ph.D. candidate in the Department of Chemical and Biomolecular Engineering at KAIST, and Si Jae Park, Assistant Professor of the Environmental Engineering and Energy Department at Myongji University. Won Jun Kim and Jung Eun Yang, both doctoral students in the Department of Chemical and Biomolecular Engineering at KAIST, also participated in the research. This research was supported by the Technology Development Program to Solve Climate Change’s research project titled “Systems Metabolic Engineering for Biorefineries” from the Ministry of Science, ICT and Future Planning through the National Research Foundation of Korea (NRF-2012M1A2A2026556). Figure: Production of PLGA and Other Non-Natural Copolymers This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced a variety of PLGAs with different monomer compositions, proposing the chemosynthetic process of non-natural polymers from biomass. The non-natural polymer PLGA and its other copolymers, which were produced by engineered bacteria developed by taking a systems metabolic engineering approach, accumulate in granule forms within a cell.
2016.03.08
View 9424
Asia Pacific Biotech News' Special Coverage of Korean Biotechnology
The Asia Pacific Biotech News covered five major biotechnology research projects sponsored by the Korean government in the areas of biofuels, biomedicine, bio-nano healthcare, and biorefinery. The Asia Pacific Biotech News (APBN), a monthly magazine based in Singapore, which offers comprehensive reports on the fields of pharmaceuticals, healthcare, and biotechnology, recently published a special feature on Korea’s biotechnology research and development (R&D) programs. The magazine feature selected five research programs sponsored by the Korean government, which are either part of the Global Frontier or the Climate Change Technology Development Projects. The programs are: Systems Metabolic Engineering Research: Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department at the Korea Advanced Institute of Science and Technology (KAIST) has been leading a research group to develop biorefining technology using renewable non-food biomass to produce chemicals, fuels, and materials that were largely drawn from fossil resources through petrochemical refinery processes. Applying a systems metabolic engineering approach, the group succeeded in modifying the metabolic pathways of microorganisms. As a result, they produced, for the first time in the world, engineered plastic raw materials and gasoline. The team also developed a technique to produce butanol and succinic acid with a higher titer and yield using metabolically engineered microorganisms. Next-generation Biomass Research: Under the leadership of Professor Yong- Keun Chang of the Chemical and Biomolecular Engineering Department at KAIST, the research project, which belongs to the Global Frontier Project, develops biofuels and bioproducts utilizing microalgae typically found in water and other marine systems. Convergence Research for Biomedicine: Professor Sung-Hoon Kim of Seoul National University leads this project that develops targeted new drugs based on convergence research strategies. Bionano Healthcare Chip Research: Director Bong-Hyun Chung of the Korea Research Institute of Bioscience and Biotechnology has integrated information and communications technology, nanotechnology, and biotechnology to develop a diagnostic kit that can screen toxic germs, virus, and toxic materials in a prompt and accurate manner. Biosynergy Research: Led by Professor Do-Hun Lee of the Bio and Brain Engineering Department at KAIST, this research project develops new treatments with a multi-target, multi-component approach in the context of systems biology through an analysis of synergistic reactions between multi-compounds in traditional East Asian medicine and human metabolites. In East Asian medicine, treatment and caring of the human body are considered analogous to the politics of governing a nation. Based on such system, the research focuses on designing a foundation for the integration of traditional medicine with modern drug discovery and development. Director Ilsub Baek at the Platform Technology Division of the Ministry of Science, ICT and Future Planning, Republic of Korea, who is responsible for the Global Frontier Program and the Technology to Solve Climate Change, said, “It is great to see that Asia Pacific Biotech News published an extensive coverage of Korea’s several key research programs on biotechnology as its first issue of this year. I am sure that these programs will lead to great outcomes to solve many worldwide pending issues including climate change and healthcare in the aging society.” Professor Sang Yup Lee, who served as an editor of the feature, said, “At the request of the magazine, we have already published lead articles on our biotechnology research three times in the past in 2002, 2006, and 2011. I am pleased to see continued coverage of Korean biotechnology by the magazine because it recognizes the excellence of our research. Biotechnology has emerged as one of the strong fields that addresses important global issues such as climate change and sustainability.”
2016.02.04
View 9780
A Firefighter Drone That Flies and Crawls Up Walls
KAIST researchers developed a wall-climbing scout drone to fight fires in high-rises, finding the source of the fires and locating people trapped inside. The 1974 American disaster film Towering Inferno depicted well the earnest struggles of firefighters engaged in ending a fire at a 138-story skyscraper. To this day, fires at high-rise buildings are considered one of the most dangerous disasters. Skyscraper fires are particularly difficult to contain because of their ability to spread rapidly in high-occupant density spaces and the challenge of fighting fires in the buildings’ complex vertical structure. Accessibility to skyscrapers at the time of the fire is limited, and it is hard to assess the initial situation. A research team at KAIST led by Professor Hyun Myung of the Civil and Environmental Engineering Department developed an unmanned aerial vehicle, named the Fireproof Aerial RObot System (FAROS), which detects fires in skyscrapers, searches the inside of the building, and transfers data in real time from fire scenes to the ground station. As an extended version of Climbing Aerial RObot System (CAROS) that was created in 2014 by the research team, the FAROS can also fly and climb walls. The FAROS, whose movements rely on a quadrotor system, can freely change its flight mode into a spider’s crawling on walls, and vice versa, facilitating unimpeded navigation in the labyrinth of narrow spaces filled with debris and rubble inside the blazing building. The drone “estimates” its pose by utilizing a 2-D laser scanner, an altimeter, and an Inertia Measurement Unit sensor to navigate autonomously. With the localization result and using a thermal-imaging camera to recognize objects or people inside a building, the FAROS can also detect and find the fire-ignition point by employing dedicated image-processing technology. The FAROS is fireproof and flame-retardant. The drone’s body is covered with aramid fibers to protect its electric and mechanical components from the direct effects of the flame. The aramid fiber skin also has a buffer of air underneath it, and a thermoelectric cooling system based on the Peltier effect to help maintain the air layer within a specific temperature range. The research team demonstrated the feasibility of the localization system and wall-climbing mechanism in a smoky indoor environment. The fireproof test showed that the drone could endure the heat of over 1,000° Celsius from butane gas and ethanol aerosol flames for over one minute. Professor Myung said, “As cities become more crowded with skyscrapers and super structures, fire incidents in these high-rise buildings are life-threatening massive disasters. The FAROS can be aptly deployed to the disaster site at an early stage of such incidents to minimize the damage and maximize the safety and efficiency of rescue mission.” The research team has recently started to enhance the performance of the fireproof design for the exteroceptive sensors including a 2-D laser scanner and a thermal-imaging camera because those sensors could be more exposed to fire than other inside sensors and electric components. This research was funded by the KAIST Initiative for Disaster Studies and the KAIST Institute. YouTube link: https://youtu.be/gPNRZi0EPQw Picture 1: Demonstration of Wall-climbing The Fireproof Aerial RObot System (FAROS) is a wall-climbing scout drone developed to conduct explorations into the site of skyscraper fires. It has an ability to climb walls in smoky, narrow spaces inside buildings. Figure 2: An Ability to Withstand Fires The FAROS can endure the heat of over 1,000° Celsius from butane gas and ethanol aerosol flames for over one minute.
2016.01.20
View 13738
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