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Successful Development of Excavation System of Biomarkers containing Protein Decomposition Control Enzyme Information
A Korean team of researchers successfully developed a biomarker excavation system named E3Net that excavates biomarkers containing information of the enzymes that control the decomposition of proteins. The development of the system paved the possibility of development of new high quality biomarkers. *Biomarker: Molecular information of unique patterns derived from genes and proteins that allow the monitoring of physical changes from genetic or environmental causes. Professor Lee Kwan Soo’s team (Department of Biological Sciences) composed of Doctorate candidate Han Young Woong, Lee Ho Dong Ph.D. and Professor Park Jong Chul published a dissertation in the April edition of Molecular and Cellular Proteomics. (Dissertation Title: A system for exploring E3-mediated regulatory networks of cellular functions). Professor Lee’s team compiled all available information of the enzyme that controls protein decomposition (E3 enzyme) and successfully compiled the inter-substrate network by extracting information from 20,000 biology related data base dissertations. The result was the development of the E3Net system that analyzes the related cell function and disease. Cells have a system that produces, destroys, and recycles proteins in response to the ever changing environmental conditions. Error in these processes leads to disease. Therefore finding the relationship between E3 enzymes that control the decomposition of proteins and the substrates will allow disease curing and prevention to become much easier. E3 enzyme is responsible for 80% of the protein decomposition and is therefore predicted to be related to various diseases. However the information on E3 enzyme and inter-substrate behavior are spread out among numerous dissertations and data bases which prevented methodological analysis of the role of the related cells and characteristics of the disease itself. Professor Lee’s team was successful in creating the E3Net that compiled 2,201 pieces of E3 substrate information, 4,896 pieces of substrate information, and 1,671 pieces of inter-substrate relationship information. This compilation allows for the systematic analysis of cells and diseases. The newly created network is 10 times larger than the existing network and is the first case where it is possible to accurately find the cell function and related diseases. It is anticipated that the use of the E3Net will allow the excavation of new biomarkers for the development of personalized drug systems. The research team applied the E3Net to find tens of new candidate biomarkers related to the major modern diseases like diabetes and cancer.
2012.05.30
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Quantum Mechanical Calculation Theory Developed
An Electron Density Functional Calculation Theory, based on the widely used quantum mechanical principles and yet accurate and with shortened calculation period, was developed by Korean research team. *Electron Density Functional Calculation Theory: Theory that proves that it is possible to calculate energy and properties with only simple wave equations and electron densities. The research was conducted by Professor Jeong Yoo Sung (Graduate School of EEWS) and Professor William Goddard with support from WCU Foster Project initiated by Ministry of Education, Science and Technology and Korea Research Foundation. The result was published in the Proceedings of the National Academy of Sciences Journal. The research team corrected the error when performing quantum calculations that arises from the length of calculation time and incorrect assumptions and developed a theory and algorithm that is more accurate and faster. The use of wave equations in quantum mechanical calculations results in high accuracy but there is a rapid increase in calculation time and is therefore difficult to implement in large molecules with hundreds, or thousands of atoms. By implementing a low electron density variable with relatively less calculation work, the size of calculable molecule increases but the accuracy decreases. The team focused on the interaction between electrons with different spins to improve upon the speed of calculation in the conventional accurate calculation. The team used the fact that the interaction between electrons with different spins increases as it comes closer together in accordance with the Pauli’s Exclusion Principle. In addition the interaction between electrons are local and therefore can ignore the interactions between far away electrons and still get the total energy value. The team also took advantage of this fact and developed the algorithm that decreased calculation time hundredth fold. Professor Jeong commented that, “So far most of the domestic achievements were made by focusing on integrative researches by calculation science and material design communities but these involved short time frames. In areas that required lengthy time frames like fundamentals and software development, there was no competitive advantage. However this research is significant in that a superior solution was developed domestically”.
2012.01.31
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Honorary Doctorate Presented to President of the Royal Swedish Academy of Sciences
KAIST presented to Dr. Svante Lindqvist, President of the Royal Swedish Academy of Sciences and Marshal of the Realm to the Swedish Royal Court, an honorary doctorate in science and technology on the 21st of November at Fusion Hall, KI Building. Dr. Lindqvist, a pioneer in the field of history of science and technology, showed how science and technology have affected the development of human civilization. His work in explaining the relationship between science and history made it easier to the public to understand the importance of science in our society, upon which he was conferred the honorary doctorate. Director Lindqvist obtained a doctorate from the Uppsala University of Sweden in 1984 with the dissertation, “Introduction of Steam Locomotive in 18th century Sweden.” This single dissertation won him three awards, which has been regarded even today as an introductory reading text to readers in the field of science history. Dr. Lindqvist established the Department of History of Science and Technology in Sweden Royal Institute of Technology in 1989 and was the department chair for nine years until 1997. He then became the founding director of the Nobel Museum from 1998 to 2009 and developed the museum from a mere display venue of Nobel’s legacy to a multifunctional research oriented institute that supports and holds various outreach activities such as seminars and public lectures. From the visit of Dr. Lindqvist to KAIST, students had a wonderful opportunity to engage with an internationally renowned scholar and, once more, to remind the university"s vision and mission, whereby they make contributions to the development of science, and ultimately, to the advancement of humanity.
2011.12.13
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Professor Kim Seung Woo and Professor Ko Kyu Young Receive the 7th Gyeong Am Scholar Awards.
Professors Kim Seung Woo and Ko Kyu Young of KAIST were named the winners for the 7th Gyeong Am Scholar Awards. The award winners are: Professor Ko Kyu Young of KAIST in the Biological Sciences category, Professor Kim Seung Woo of KAIST in the Engineering category, Professor Kim Young Shik of Seoul National University and Professor Kil Hui Seoung of Sogang University in the Humanities category, and Professor Hong Byoung Hee of Seoul National University in the Natural Sciences category. In the Liberal Arts category leader of Universal Ballet Company Moon Hoon Sook was chosen, and the Special Achievement Award was given to Historian Dr. Park Myoung Sun. Professor Ko discovered that it is Angionpoietin-1 that induces the growth of new blood vessels and thus made a significant contribution to the field of blood vessel formation, immune mechanism, and causes of cancer spread. Professor Kim developed a mini extreme ultra violet laser light source using the resonance principles of plasmon and made a great contribution in the acquiring of core technologies and its industrial commercialization in the field of super precise optical instruments. Gyeong Am Education and Culture Foundation was founded by the Chairman of Tae Yang Group, Song Geum Jo who had donated his entire fortune amounting to 100billion Korean Won to society by creating a public foundation aimed at encouraging advancements in learning, training of experts, and cultural developments for the betterment of Korea. The Gyeong Am Scholar Awards was established in 2005 and recognizes those scholars and artists who are making significant contributions in the frontlines of society. The awards ceremony is to be held at Busan on the 4th of November, three thirty in the afternoon and the winner of each category is to receive 100mil Korean Won in prize money with a commemorative plaque.
2011.09.26
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KAIST Successfully Demonstrates Mobile Harbor in the Open Sea
Busan, South Korea—Large container ships are no longer required to come into ports to transport cargo, as KAIST has developed an innovative technology that will transform the paradigm of today’s cargo handling operations. A Mobile Harbor is a vessel that carries a large stabilized crane with a smart spreader and multistage trolley system, enabling the loading and unloading of ship cargo on the wavy open sea. Following a successful docking of two vessels at sea in April of this year, KAIST conducted a full scope of Mobile Harbor operations in the inner sea of Busan, South Korea, on June 29, 2011. Initiated in 2009, the Mobile Harbor (MH) is one of the university’s flagship research projects, which aims to provide a new growth engine that will lead the Korean economy to the next level of advancement, and to develop green technology through multidisciplinary and convergence research. The idea of MH came to light when thinking outside the box (why can’t a harbor go out to meet a ship on voyage and retrieve goods instead of ships coming into the harbor?) to improve problems relating to the current maritime transport system, such as port congestion, environmental issues caused by heavy sea transport, increased demand for supersized container ships, and the need for port construction and expansion. The essential technology to establish a Mobile Harbor is a docking system and crane system that can overcome the obstacles imposed by the sea, i.e., waves and wind. Connecting two operating vessels of different sizes in the unpredictable and ever-changing environment of the sea was regarded as “impossible” and had never been tried before, but, on April 26, 2011, KAIST successfully demonstrated the technology to moor vessels safely and securely. The Mobile Harbor has a unique way of mooring vessels that are anchored at sea: its flexibly designed robot arms with a square-shape vacuum suction pad at the tip reach out and attach to the hull of a container ship for docking. Each robot arm is connected to a cable and winch that further add stability to the Mobile Harbor. Foam-filled fenders are placed between the Mobile Harbor and the container ship, thereby maintaining a safe distance to prevent collisions. The crane system consists of a multistage trolley, smart spreader, and tension controller, all of which provide the crane with functionality and stability to move around cargo containers in the sea. The crane system also has various sensors like cameras and laser scanners, and therefore, it can gauge the movement of the spreader and ships as well as trace a target container in real time. As a result, the spreader, a container grabbing device, is free from the swing motions when lifting and putting down cargo and grabs a target container safely in the wavy open sea. During today’s at-sea demonstration in Busan, a research team from the KAIST Mobile Harbor Center docked a Mobile Harbor (a barge ship) right next to a container vessel (the other barge ship) and repeated freight transport operations between the two ships, presenting the great potential to commercialize the Mobile Harbor technology. The project has been implemented in collaboration with industries, research institutes, and universities in such fields as mechanical engineering, robotics, automation engineering, and ocean systems engineering. The demonstration proceeded with a wide range of participants including researchers, engineers, government officials, and entrepreneurs from Korea and around the world. Byung-Man Kwak, Director of the KAIST Mobile Harbor Center, explained his feelings on the successful demonstration: “It’s been a remarkable journey to develop a Mobile Harbor from scratch, and I’m genuinely thrilled to showcase what we have accomplished so far. Today’s demonstration of Mobile Harbor’s core technologies will really change the face of our maritime transportation system. We will be able to deliver more goods to global markets and consumers via sea route, not necessarily building more ports or expanding the existing harbors. KAIST’s Mobile Harbor will also significantly cut down the high cost related to overland transportation of cargo and in return, contribute to the reduction of carbon emission.” The Center has received much interest in possible market migration and broader application of the Mobile Harbor from businesses and organizations, e.g., US Office of Naval Research, King Fahd University of Petroleum and Minerals, Saudi Aramco, POSCO, and the Korean Navy.
2011.07.06
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University Alums go out directly in search of Creative Future Talents
KAIST decided to involve 140 alums in the interview process for the class enrolled in 2012. The alums participating in the interview process will be focusing on the finding of creative science and technology talent and the characteristics of becoming a leader in the math and science fields. Those alums participating in the interview process are from all walks of life including representatives of industries, universities professors, researchers, and public servants. The reason for the inclusion of the alums in the admissions process is to stress the togetherness of KAIST family and take another step to becoming a world class university.
2011.06.24
View 7443
Late Dr. Ryu Geun Chul's Achievements and Generous Contributions
First Doctor in the field of Korean Traditional Medicine The late Dr. Ryu was born in 1926 and is the father figure of Korea’s Traditional Medicine and is its First Doctor (1976 Kyung Hee University), and was the vice-professor of Kyung Hee University of Medicine, Vice-Director of Kyung Hee Institute of Korean Traditional Medicine, and was the first chairman of the Association of Korea Oriental Medicine. He developed the painless acupuncture administering device for the first time in Korea in 1962, and succeeded in anesthetizing a patient for cesarean procedure using acupuncture in 1972. He even was the first to receive a medical engineering doctorate degree from the Moscow National Engineering School in April of 1996 and developed a stroke rehabilitation machine. Korea’s Most Generous Donor Dr. Ryu surprised the world by donating 57.8billion Won worth of real estate to KAIST in August of 2008. Dr. Ryu revealed that his reason for donating such a huge sum to KAIST was due to its focused students giving him the belief that the future of Korea is at KAIST and that the development of science and technology is necessary for Korea to develop into a world class nation and KAIST is the institute most suitable to lead Korea in the field. Dr. Ryu lived on KAIST campus after donating his entire fortune and even established ‘KAIST scholars and spacemen health research center’ and ‘Dr. Ryu Health Clinic’ as he also wanted to donate his knowledge. Even when he was a professor at Moscow National Engineering University in the late 1990s he carried out free medical work throughout Korea and in recognition of his devoted work, he was named honorary citizen from Chun Ahn city, San Chung city, and DaeJeon city. In 2007 he donated 450million Won to Cheon Dong Elementary School in Chun Ahn city to build a gymnasium and an indoor golf practice range. Role as Science and Technology Public Relations Officer Dr. Ryu volunteered to numerous lectures and interviews after donation to advertise science and technology. His belief that the development of science and technology is necessary for Korea’s development was the driving force behind his efforts at increasing interest and support for the field of science and technology. In addition, through interviews with MBC, KBS, SBS, KTV, Joong Ang Newspapers, Dong Ah Newspaper and other media mediums, Dr. Ryu improved the public perception on donations whilst increasing the pride of scientists and researchers by highlighting their importance and the importance of science and technology. In recognition of Dr. Ryu’s efforts, he received the 43rd Science Day Science and Technology Creation Award, 2010 MBC Social Service Special Award, and 2010 ‘Proud Chung Cheong Citizen’ Award.
2011.03.22
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Graduate School of Medical Sciences sign Exchange Agreement with Yonsei Graduate School of Medicine
KAIST’s Graduate School of Medical Sciences signed on the 22nd of February an Exchange Agreement with the Yonsei Graduate School of Medicine. The Agreement was signed with hopes of cooperation in research in the field of medical science and will establish a Cooperation Committee. The committee will put in motion cooperative research, training programs, exchange students, exchange of technology, and hold symposiums and seminars. The representatives stated that the agreement is more than just a symbolic, ceremonial agreement. The agreement was made so that both graduate schools will develop into a world-class research institute in medical sciences.
2011.03.02
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Professor Kang Suk Joong receives 'Korea Engineering Award.'
KAIST”s Professor Kang Suk Joong of the Department of Material Science and Engineering received ‘Korea Engineering Award’ from the Ministry of Education, Science and Technology and Korea Research Foundation. The award is given to those professors who have accomplished world class research and results. Professor Kang has potentially redirected the direction of research in the field of the microstructure of materials by explaining the fundamental principle behind how the microstructure of a material that affects the physical properties of the polycrystalline structure and changes through processing. Professor Kang applied the results of his findings in the manufacture of new materials and made significant contributions to Korean Material Engineering Industry and was consequently awarded the award. The ‘Korea Engineering Award’ was thought of in 1994 and a total of 24 recipients were recognized through the award in various fields like electronics, mechanics, chemistry, construction, etc. The recipient is awarded in addition the President’s award and 50million won as prize money. The ceremony for ‘Korea Engineering Award’ and the ‘Young Scientist Award’ was held in Seoul Press Center Press Club on the 22nd of December at 3pm. The Minister of Education, Science and Technology (Lee Joo Ho), member of Board of Directors of the Korea Research Foundation (Kim Byoung Gook), Director of Korea Science and Technology Archive (Jeong Gil Seng), along with the recipients attended the ceremony. In addition, Professor Kang was appointed as Distinguished Professor in March 2010 in recognition of his research accomplishments.
2011.01.18
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The 9th International Conference on Entertainment Computing Held, Sep 8-11, 2010
The cyber world is no longer an unrealistic place for a contemporary man who spends most of his time in front of a computer nowadays. The entertainment contents industry, which materializes the cyber world, leads the new knowledge economy and is emerging as a new growth engine for high value-added industry. Professionals in entertainment computing gathered to discuss how to make the cyber space more elaborate and entertaining. The 9th 2010 International Conference on Entertainment Computing (ICEC) was held from September 8 to September 11 at Seoul COEX by KAIST and International Federation for Information Processing (IFIP). This year’s theme is “Creative and Innovative Science, Computing and Design for Digital and Entertainment Contents in 21C”, with fifteen global leaders of industry-university-institute collaboration speakers including George Joblove (Executive VP of Sony Pictures Technologies), Massimiliano Gasparri (VP of Warner Bros. Advanced Digital Services), Don Marinelli (Executive Producer of Entertainment Technology Center at University of Carnegie Mellon), Keith Devlin (Founding Executive Director of Stanford Media-X and Executive Director of Stanford H-STAR), Roy Ascott (President of Planetary Collegium). Speeches, paper sessions, workshops, exhibitions on the high-tech digital entertainment industry including computer graphics, cyber reality, telepresence, 3D/4D, mobile games, animation, special effects, robot design, content production and distribution, media art were held at the conference this year. This event was sponsored by IEEE, ACM, IPS, ADADA, Elsevier, ETRI, SK Telecom, KIISE, KMMS, HCI Korea, KCGS and KCGS.
2010.09.17
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Nanowire crystal transformation method was newly developed by a KAIST research team.
Figure 1 Schematic illustration of NW crystal transformation process. FeSi is converted to Fe3Si by high-temperature thermal annealing in diluted O2 condition and subsequent wet etching by 5% HF. Figure 2 Low-resolution TEM images of FeSi; Fe3Si@SiO2 core—shell; Fe3Si NW after shell-etching; and Scale bars are 20 nm Professor Bongsoo Kim of the Department of Chemistry, KAIST, and his research team succeeded to fabricate Heusler alloy Fe3Si nanowires by a diffusion-driven crystal structure transformation method from paramagnetic FeSi nanowires. This methodology is also applied to Co2Si nanowires in order to obtain metal-rich nanowires (Co) as another evidence of the structural transformation process. The newly developed nanowire crystal transformation method, Professor Kim said, would be valuable as a general method to fabricate metal-rich silicide nanowires that are otherwise difficult to synthesize. Metal silicide nanowires are potentially useful in a wide array of fields including nao-optics, information technology, biosensors, and medicine. Chemical synthesis of these nanowires, however, is challenging due to the complex phase behavior of silicides. The metal silicide nanowires are grown on a silicon substrate covered with a thin layer of silicon oxide via a simple chemical vapor deposition (CVD) process using single or multiple source precursors. Alternatively, the nanowires can be grown on the thin silicon oxide film via a chemical vapor transport (CVT) process using solid metal silicide precursors. The CVT-based method has been highly effective for the syntheses of metal silicide NWs, but changing the composition of metal silicide NWs in a wider range, especially achieving a composition of a metal to silicon, has been quite difficult. Thus, developing efficient and reliable synthetic methods to adjust flexibly the elemental compositions in metal silicide NWs can be valuable for the fabrication of practical spintronic and neonelectronic devices. Professor Kim expliained, “The key concept underlying this work is metal-enrichment of metal silicide NWs by thermal diffusion. This conversion method could prove highly valuable, since novel metal-rich silicide NWs that are difficult to synthesize but possess interesting physical properties can be fabricated from other metal silicide NWs.” The research result was published in Nanao Letters, a leading peer-reviewed journal, and posted online in early August 2010.
2010.08.25
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South Koreans Develop High-Performance Software Router.
HPC Wire, covering news on computing software, hardware, networking, storage, tools and applications, published an article on the development of high-performance router by a KAIST research team. The research team consisted of the Departments of Computer Science and Electrical Engineering, KAIST, presented PacketShader, a high-performance software router framework for general packet processing with Graphics Processing Unit (GPU) acceleration. PacketShader, the research team said, that exploits the massively-parallel processing power of GPU to address the CPU bottleneck in current software routers. For the article, please click the link: http://www.hpcwire.com/news/South-Koreans-Develop-High-Performance-Software-Router-101401434.html
2010.08.25
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