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Jaewook Myung, First Korean Selected as '40 Under 40 Recognition Program' Next Generation Environmental Engineering Leader
< Professor Jaewook Myung of KAIST Department of Civil and Environmental Engineering >
KAIST announced on December 12th that Professor Jaewook Myung of the Department of Civil and Environmental Engineering was selected as the first Korean recipient of the '40 Under 40 Recognition Program' for Next Generation Environmental Engineering Leaders, organized by the American Academy of Environmental Engineers and Scientists (AAEES).
< The '40 Under 40 Recognition Program' is an international award program selecting next-generation leaders in the field of Environmental Engineering and Science >
This award is presented annually by AAEES to select next-generation environmental engineering researchers who demonstrate innovative research achievements, social contribution, and educational leadership. Professor Myung's selection is particularly significant as he is the first Korean to be chosen since the program's inception. The award ceremony is scheduled to be held in Washington D.C. in April 2026.
AAEES is the world's highest-authority professional organization leading the global environmental engineering sector through operating the Professional Environmental Engineer (PEE) certification system, policy consultation, and international academic exchange. This award is highly regarded for greatly enhancing the international standing of domestic environmental engineering and sustainability research.
Amid the deepening problems of plastic waste increase and greenhouse gas emissions, where existing technologies are showing limitations in providing solutions, Professor Jaewook Myung has garnered significant attention from academia and industry by developing technology to convert greenhouse gases such as methane ($CH_4$) and carbon dioxide ($CO_2$) into biodegradable plastics. His research is highly praised for presenting a new industrial paradigm that fuses environmental microbiology and materials science to convert greenhouse gases into high-value bio-materials.
Professor Myung's research team secured microbial metabolic control technology to transform greenhouse gases into materials, an accelerated process that simultaneously enhances the synthesis and decomposition efficiency of plastics, and pilot process design and engineering technology applicable in industrial settings. This established a sustainable circular technology model capable of simultaneously addressing greenhouse gas reduction and plastic pollution issues.
Furthermore, the research team expanded these foundational technologies to develop various application products, such as biodegradable coating materials that naturally decompose in the ocean, biocompatible bio-based electronic materials, and industrial 3D printing filaments, realizing full-cycle innovation from basic research to application and industrialization. These achievements are recognized as world-class sustainable technology alternatives that can simultaneously overcome the problems of plastic downcycling and the economic limitations of greenhouse gas utilization technology.
Professor Myung also shows excellent performance in nurturing talent. His advised students are growing into next-generation environmental and sustainability researchers, having won major awards both domestically and internationally, including the American Chemical Society (ACS) Environmental Chemistry Graduate Student Award, the Presidential Science Scholarship, the Merck Innovation Cup Prize, and the Republic of Korea Talent Award. He is also establishing himself as a leading researcher in the commercialization of sustainable technology by expanding his research achievements into the social and industrial ecosystem through technology collaboration with industries, patents, and consultation with public institutions.
The AAEES Selection Committee evaluated Professor Jaewook Myung as "a researcher possessing technical excellence, social responsibility, and educational leadership, and an innovator who has pioneered new areas of environmental engineering." Professor Myung expressed his thoughts, saying, "This award is a result made possible by the students who researched and challenged alongside me and the collaborative research culture of KAIST," and added, "I will contribute to brightening the future of humanity and the planet through sustainable resource circulation technology."
2025.12.12 View 1365 -
KAIST Unveils Cause of Performance Degradation in Electric Vehicle High-Nickel Batteries: "Added with Good Intentions
<(From left in the front row) Professor Nam-Soon Choi, Professor Dong-Hwa Seo, (back row, from left) Ph.D candidate Gihoon Lee, Ph.D candidate Seung Hee Han, Ph.D candidate Jae-Seung Kim, (top) M.S candidate Junyoung Kim>
High-nickel batteries, which are high-energy lithium-ion batteries primarily used in electric vehicles, offer high energy density but suffer from rapid performance degradation. A research team from KAIST has, for the first time globally, identified the fundamental cause of the rapid deterioration (degradation) of high-nickel batteries and proposed a new approach to solve it.
KAIST announced on December 3rd that a research team led by Professor Nam-Soon Choi of the Department of Chemical and Biomolecular Engineering, in collaboration with a research team led by Professor Dong-Hwa Seo of the Department of Materials Science and Engineering, has revealed that the electrolyte additive 'succinonitrile (CN4), which has been used to improve battery stability and lifespan, is actually the key culprit causing performance degradation in high-nickel batteries.
In a battery, electricity is generated as lithium ions travel between the cathode and the anode. A small amount of CN4 is included in the electrolyte to facilitate the movement of lithium. The research team confirmed through computer calculations that CN4, which has two nitrile (-CN) structures, attaches excessively strongly to the nickel ions on the surface of the high-nickel cathode.
The nitrile structure is a 'hook-like' structure, where carbon and nitrogen are bound by a triple bond, making it adhere well to metal ions. This strong bonding destroys the protective electrical double layer (EDL) that should form on the cathode surface. During the charging and discharging process, the cathode structure is distorted (Jahn-Teller distortion), and even electrons from the cathode are drawn out to the CN4, leading to rapid damage of the cathode.
Nickel ions that leak out during this process migrate through the electrolyte to the anode surface, where they accumulate. This nickel acts as a 'bad catalyst' that accelerates electrolyte decomposition and wastes lithium, further speeding up battery degradation.
Various analyses confirmed that CN4 transforms the high-nickel cathode surface into an abnormal layer deficient in nickel, and changes the normally stable structure into an abnormal 'rock-salt structure'.
This proves the dual nature of CN4: while useful in LCO batteries (lithium cobalt oxide), it actually causes the structural collapse in high-nickel batteries with a high nickel ratio.
This research holds significant meaning as a precise analysis that goes beyond simple control of charging/discharging conditions, to even elucidating the actual electron transfer occurring between metal ions and electrolyte molecules. Based on this achievement, the research team plans to develop a new electrolyte additive optimized for high-nickel cathodes.
<Schematic diagram of the ligand coordination between CN₄ molecules and Ni³⁺ on the high-nickel cathode surface and the cathode structural degradation process>
Professor Nam-Soon Choi stated, "A precise, molecular-level understanding is essential to enhance battery lifespan and stability. This research will pave the way for the development of new additives that do not excessively bond with nickel, significantly contributing to the commercialization of next-generation high-capacity batteries."
This research, jointly led by Professor Nam-Soon Choi, Seung Hee Han, Junyoung Kim, and Gihoon Lee of the Department of Chemical and Biomolecular Engineering, and Professor Dong-Hwa Seo and Jae-Seung Kim of the Department of Materials Science and Engineering as co-first authors, was published online on November 14th in the prestigious international journal 'ACS Energy Letters' and was selected as the cover article.
※ Paper Title: Unveiling Bidentate Nitrile-Driven Structural Degradation in Ultra-High-Nickel Cathodes,
https://doi.org/10.1021/acsenergylett.5c02845
<Cover Page of International Journal(ACS Energy Letters)>
The research was supported by Samsung SDI.
2025.12.03 View 1873 -
The World's Smallest Fully Wireless Neural Implant Achieved
< (From left) Sunwoo Lee, KAIST Joint Professor, Alyosha Molnar, Cornell University Professor >
The human brain contains about 100 billion brain cells, and the chemical and electrical signals they exchange create most mental functions. Neural implant technology for precisely reading these signals is essential for the research and treatment of neurodegenerative diseases. A research team from KAIST and international collaborators has successfully implemented a fully wireless, ultra-small implant, which was previously only a theoretical possibility, going beyond simple miniaturization and weight reduction of neural implants.
KAIST announced on the November 27th that a joint research team led by Professor Sunwoo Lee (Joint Professor in Materials Science and Engineering at KAIST and from the School of Electrical and Electronic Engineering at Nanyang Technological University, NTU) and Professor Alyosha Molnar's team from Cornell University in the US has developed 'MOTE (Micro-Scale Opto-Electronic Tetherless Electrode)', an ultra-small wireless neural implant less than 100 micrometers (µm) — smaller than a grain of salt. The team successfully implanted this device into the brains of laboratory mice and stably measured brain waves for one year.
In the brain, invisible, minute electrical signals constantly move, creating our various mental activities such as memory, judgment, and emotion. The technology to directly measure these signals outside the body without connecting wires has been highlighted as key for brain research and the treatment of neurological disorders like dementia and Parkinson's disease.
However, existing implants have limitations: their thick wired structure causes movement in the brain, leading to inflammation and signal degradation over time, and their size and heat generation restrict long-term use.
To overcome these limitations, the research team created an ultra-small circuit based on the existing semiconductor process (CMOS) and combined it with their self-developed ultra-fine Micro-LEDs (µLEDs) to drastically miniaturize the device. They also applied a special surface coating to significantly enhance durability, allowing it to withstand the biological environment for a long time.
The resulting MOTE is less than 100 µm thick and has a volume of less than 1 nanoliter, making it thinner than a human hair and smaller than a grain of salt, the world's smallest level among currently reported wireless neural implants.
Another key feature of MOTE is that it is a fully wireless system that requires no battery. The device is structured to receive external light to generate power, detect brain waves, and then transmit the information back outside embedded in the light signal using Pulse Position Modulation (PPM).
This method drastically reduces energy consumption, minimizes the risk of heat generation, and eliminates the need for battery replacement, enabling long-term use.
The research team conducted a one-year long-term experiment by implanting the ultra-small MOTE into the brains of mice. The results showed normal brain wave measurement over the extended period, with almost no inflammation observed around the implant and no degradation in device performance.
This is considered the first clear demonstration that an ultra-small wireless implant can maintain normal function for a prolonged time inside a living body.
< MOTE neural implant on a salt crystal (left), MOTE neural implants after 296 days of implantation in a laboratory mouse (right) >
Professor Sunwoo Lee stated, "The greatest significance of the newly developed neural implant lies in its actual implementation of a fully wireless, ultra-small implant that was previously only anticipated as a possibility, going beyond simple miniaturization and weight reduction." He added, "This proves the technological possibility of resolving not only the known unknowns raised during the development and use of wireless neural implants, but also the unknown unknowns that newly emerge during the actual development process."
He further added, "This technology will be broadly applicable not only to brain science research but also to nervous system disease monitoring and the development of long-term recording-based treatment technologies."
The research results were published online in the prestigious journal Nature Electronics on November 3rd. ※ Paper Title: A subnanolitre tetherless optoelectronic microsystem for chronic neural recording in awake mice, DOI: https://doi.org/10.1038/s41928-025-01484-1
This research was supported by the US National Institutes of Health (NIH), Nanyang Technological University (Singapore), the Singapore National Research Foundation, the Singapore Ministry of Education, and the ASPIRE League Partnership Seed Fund 2024. The specialized fabrication processes were conducted at the Cornell NanoScale Facility (part of the US National Nanotechnology Coordinated Infrastructure, NNCI) and NTU's Nanyang NanoFabrication Centre.
2025.11.27 View 1777 -
KAIST K HERO Rides Nuri Rocket, Next Generation Micro Hall Thruster Technology Verified in Space
< (From left) Ph.D candidate Jaehong Park, COSMOVY researcher Yoonsoo Kim, Professor Wonho Choe, Ph.D candidate Dongha Park, M.S candidate Seungbeom Heo >
KAIST announced on the November 26th that the CubeSat 'K-HERO (KAIST Hall Effect Rocket Orbiter)', developed by the research team of Professor Wonho Choe from the Department of Nuclear and Quantum Engineering, is scheduled to launch into space aboard the 4th Nuri rocket launch vehicle on November 27th from the Naro Space Center in Goheung, Jeollanam-do.
This 4th Nuri launch is the first to be managed by the private company Hanwha Aerospace, which received technology transfer from the Korea Aerospace Research Institute (KARI), marking a significant milestone in the transformation of the domestic space industry. Along with the main payload, the Next-Generation Medium Satellite 3, twelve CubeSats developed by industry, academia, and research institutions will be onboard, with K-HERO being one of them.
The development of K-HERO was officially initiated when Professor Wonho Choe's research team was selected as the basic satellite development team in the '2022 CubeSat Competition' organized by KARI.
The basic satellite is a technology verification satellite designed to confirm whether the design and core components operate normally in the space environment before proceeding with the flight model (FM) production. K-HERO is a 3U standard CubeSat with dimensions of $10\text{ cm}$ (width) $\times$ $10\text{ cm}$ (length) $\times$ $30\text{ cm}$ (height) and a weight of $3.9\text{ kg}$. It was designed to satisfy all stability, electrical specifications, and interface conditions with the launch vehicle.
The core mission of K-HERO is to directly verify the in-space operation of the 150 W class micro-satellite Hall thruster developed by the research team.
The Hall thruster can be simply described as a 'space engine powered by electricity'. It is an electric propulsion engine that moves the satellite slowly but very efficiently using electricity.
Instead of burning a lot of fuel to generate instantaneous thrust, like a rocket, it works by using electricity to turn gas (Xenon) into a plasma state and rapidly accelerating it backward to push the satellite forward. Hall thrusters are considered a core technology for the era of small and constellation satellites due to their high fuel efficiency.
< Image of plasma generation in the micro-satellite Hall thruster mounted on the K-HERO CubeSat >
Hall thrusters are already a proven technology, having been used in large satellites and deep-space probes for over 20-30 years. However, their size and power requirements were large, so in the past, they were mainly operated on large geostationary (GEO) communication/broadcasting satellites and used by NASA and ESA deep-space probes for long-distance flights.
Recently, the emergence of the SpaceX Starlink satellite constellation has led to a surge in demand for small and micro electric thrusters. As the global space industry shifts towards satellite constellations, 'small and efficient thrusters' have become essential technology.
K-HERO is the first case of direct in-space demonstration of a micro Hall thruster made with domestic technology, and it is expected to be an important milestone in enhancing domestic technological competitiveness.
Professor Wonho Choe's research team began research on Hall thrusters in Korea in 2003, securing original technology based on plasma physics. In 2013, they successfully mounted a 200 W class Hall thruster on the 'KAIST Science and Technology Satellite 3,' proving its practical utility. This time, they have improved the design to operate even at a lower power of 30 W, developing a next-generation model aimed at micro-satellites.
COSMOVY Inc, a laboratory startup founded by Professor Wonho Choe's research team, also participated in the development of K-HERO, further strengthening the foundation for technology commercialization.
< K-HERO CubeSat being loaded into the Nuri rocket's CubeSat dispenser (Photo source: Korea Aerospace Research Institute) >
Professor Wonho Choe stated, "Starting with K-HERO, the number of small satellites equipped with electric thrusters will increase significantly in Korea. The Hall thruster being verified this time can be utilized for various missions, including low-Earth orbit constellation surveillance and reconnaissance satellites, 6G communication satellites, very-low-Earth orbit high-resolution satellites, and asteroid probes."
President Kwang Hyung Lee stated, "The launch of K-HERO is a significant opportunity to directly verify KAIST's electric propulsion technology on a micro-satellite platform once again in space, and it will be an important turning point that will further enhance the technological competitiveness of small satellites in Korea. KAIST will continue to contribute to the development of our country's space technology.
2025.11.26 View 2016 -
AI Opens a New Era in Medical Science and Bio
< (From left) KAIST Professors Yoonjae Choi, Tae-Kyun Kim, Jong Chul Ye, Hyunwoo Kim, Seunghoon Hong, Sang Yup Lee >
KAIST announced on the 14th of November that it has been selected as a major participating institution in the 'Lunit Consortium' for the 'AI Specialized Foundation Model Development Project' supervised by the Ministry of Science and ICT, and has officially started developing an AI foundation model for the medical science and bio fields. Through this project, KAIST plans to develop an 'AI Foundation Model Specialized for Medical Science' that encompasses the entire lifecycle of bio and medical data, and lead the creation of an AI based life science innovation ecosystem. The 'Lunit Consortium' includes 7 companies-Lunit, Trillion Labs, Kakao Healthcare, Igenscience, SK Biopharm, and Rebellion-along with 9 medical and research institutions, including KAIST, Seoul National University, NYU, National Health Insurance Service Ilsan Hospital, and Yonsei Severance Hospital. This consortium will be supported by 256 state of the art B200 GPUs to build and demonstrate a 'Chain of Evidence-Based Full-Cycle Medical Science AI Model', an AI system that connects and analyzes medical data from beginning to end, and a 'Multi-Agent Service', a system where multiple AIs collaborate to perform diagnosis and prediction. KAIST's participation in this project involves a joint research team formed by professors from the School of Computing and the Kim Jaechul Graduate School of AI. Professors Yoonjae Choi, Tae-Kyun Kim, Jong Chul Ye, Hyunwoo Kim, and Seunghoon Hong will serve as the research team, and Vice President for Research Sang Yup Lee will take on an advisory role. The research team is not merely collecting data but they are establishing a strategy (L1~L7 stages) to precisely process and systematically manage medical and life science data so that the AI can actually learn and utilize it. Through this, they plan to develop and verify an AI model that connects and analyzes diverse life science data, including medical information, gene/protein data, and new drug candidates. The data the research team aims to integrate includes a wide range from language to actual patient treatment information. Specifically, L1 represents language data, L2 is the structure of molecules, L3 is proteins and antibodies, L4 is omics data encompassing genetic and protein information, L5 is drug information, L6 is medical science research and clinical data, and L7 is real-world clinical data obtained from actual hospitals. In essence, the data handled by the AI connects everything from speech and text to molecules, proteins, drugs, clinical research, and actual patient treatment information.
< The process of training AI by viewing X ray images and doctor's interpretation (text) together (MedViLL from Professor Jae-Yoon Choi' s lab) >
Vice President Sang Yup Lee is a world-renowned scholar in the fields of synthetic biology and systems metabolic engineering, leading the establishment of a bio manufacturing platform and policy advice through the convergence of life science, engineering, and AI. He advises on the analysis of life information (omics) such as genes and proteins and designs a feedback system for verifying experimental results, supporting the Korean-developed medical AI model to secure international reliability and competitiveness. Vice President Lee stated, "AI technology is breaking down the boundaries of life science and engineering, creating a new paradigm for knowledge creation," adding, "KAIST will utilize full cycle medical science data to accelerate the era where AI uncovers the causes of diseases and predicts treatments." KAIST President Kwang Hyung Lee said, "KAIST will contribute to creating an AI-based life science innovation ecosystem, lead the innovation of national strategic industries through world-class AI-bio convergence research, and drive the progress of human health and science and technology." The model developed in the Lunit Consortium will be released as an Open License for commercial use, and is expected to expand into various medical and healthcare services such as national health chatbots. With this participation, KAIST plans to strengthen research on AI-based life science data infrastructure establishment, medical AI standardization, and AI ethics and policy advice, leading the AI transition of national bio and medical science research.
2025.11.14 View 1898 -
KAIST's 'FluidGPT' Wins Grand Prize at the 2025 AI Champion Competition
<Commemorative Photo After Winning at the 2025 AI Champions Award Ceremony>
The era has begun where an AI assistant goes beyond simple conversation to directly view the screen, make decisions, and complete tasks such as hailing a taxi or booking an SRT ticket.
KAIST (President Kwang Hyung Lee) announced on the 6th that the AutoPhone Team (Fluidez, KAIST, Korea University, Sungkyunkwan University), led by Professor Insik Shin (CEO of Fluidez Co., Ltd.) of the School of Computing, was selected as the inaugural AI Champion (1st place) in the '2025 Artificial Intelligence Champion (AI Champion) Competition,' hosted by the Ministry of Science and ICT.
This competition is the nation's largest AI technology contest, comprehensively evaluating the innovativeness, social impact, and commercial potential of AI technology. With 630 teams participating nationwide, the AutoPhone Team claimed the top honor and will receive 3 billion Korean won in research and development funding.
The technology developed by the AutoPhone Team, 'FluidGPT,' is a fully autonomous AI agent that understands a user's voice command and enables the smartphone to independently run apps, click, input, and even complete payments.
For example, when a user says, "Book an SRT ticket from Seoul Station to Busan," or "Call a taxi," FluidGPT opens the actual app and sequentially performs the necessary steps to complete the request.
The core of this technology is its 'Non-Invasive (API-Free)' structure. Previously, calling a taxi using an app required directly connecting to the app's internal system (API communication) through the taxi app's API. In contrast, this technology does not modify the existing app's code or link an API. Instead, the AI directly recognizes and operates the screen (UI), acquiring the ability to use the smartphone just like a human.
As a result, FluidGPT presents a new paradigm—"AI that sees, judges, and moves a hand on behalf of a person"—and is evaluated as a core technology that will usher in the 'AI Phone Era.'
FluidGPT moves beyond simple voice assistance to implement the concept of 'Agentic AI' (Action-Oriented Artificial Intelligence), where the AI directly views the screen, makes decisions, and takes action. As a fully action-oriented system, the AI clicks app buttons, fills in input fields, and references data to autonomously achieve the user's objective, foreshadowing an innovation in how smartphones are used.
Professor In-sik Shin of the School of Computing shared his thoughts, stating, "AI is now evolving from conversation to action. FluidGPT is a technology that understands the user's words and autonomously executes actual apps, and it will be the starting point of the 'AI Phone Era.' The AutoPhone Team possesses world-class research capabilities, and we will contribute to the widespread adoption of AI services that everyone can easily use."
KAIST President Kwang Hyung Lee remarked, "This achievement is a representative example that demonstrates KAIST's vision for AI convergence," adding, "AI technology is entering the daily lives of citizens and leading a new wave of innovation." He further added, "KAIST will continue to lead research in future core technologies such as AI and semiconductors to bolster national competitiveness."
2025.11.06 View 2334 -
KAIST Uncovers the Mechanism Behind Overactive Immune Cells
<(From Right) Professor Eui-Cheol Shin, Ph.D candidate So-Young Kim, Professor Su-Hyung Park, Professor Hyuk Soo Eun, Dr. Hoyoung Lee>
“Why do immune cells that are supposed to eliminate viruses suddenly turn against our own body?”
There are instances where killer T cells—which are meant to precisely remove virus-infected cells—malfunction like overheated engines, attacking even healthy cells and damaging tissues. A KAIST research team has now identified the key mechanism that regulates this excessive activation of killer T cells, offering new insights into controlling immune overreactions and developing therapies for immune-related diseases.
KAIST (President Kwang Hyung Lee) announced on November 5 that a research team led by Professors Eui-Cheol Shin and Su-Hyung Park from the Graduate School of Medical Science and Engineering, in collaboration with Professor Hyuk Soo Eun from Chungnam National University College of Medicine, has uncovered the molecular basis of nonspecific activation in killer T cells and proposed a new therapeutic strategy to control it.
Killer T cells (CD8⁺ T cells) selectively eliminate infected cells to prevent viral spread. However, when excessively activated, they can attack uninfected cells, causing inflammation and tissue damage. Such overactive immune responses can lead to severe viral infections and autoimmune diseases.
In 2018, Professor Shin’s team was the first in the world to discover that killer T cells can be nonspecifically activated by cytokines and randomly attack host cells—a phenomenon they termed “bystander activation of T cells”. The current study builds on that discovery by revealing the molecular mechanism driving this abnormal process.
The team focused on a cytokine called interleukin-15 (IL-15). Experiments showed that IL-15 can abnormally excite killer T cells by a bystander activation mechanism, causing them to attack uninfected host cells. However, when there is a concurrent antigen-specific stimulation, IL-15-induced bystander activation is suppressed.
The researchers further identified that this suppression occurs through an intracellular signaling process. When the concentration of calcium ions (Ca²⁺) changes, a protein called calcineurin activates, which in turn triggers a regulatory protein known as NFAT, suppressing IL-15-induced bystander activation of killer T cells. In other words, the calcineurin–NFAT pathway activated by antigen stimulation acts as a brake on overactivation by a bystander mechanism.
The team also discovered that some immunosuppressants, which are known to block the calcineurin pathway, may not always suppress immune responses—in certain contexts, they can instead promote IL-15-induced bystander activation of killer T cells. This finding underscores that not all immunosuppressants work the same way and that treatments must be carefully tailored to each patient’s immune response.
Through gene expression analysis, the researchers identified a gene set that increase only in abnormally activated killer T cells induced by IL-15 as markers. They further confirmed that these same markers were elevated in bystander killer T cells from patients with acute hepatitis A, suggesting that the markers could be used for disease diagnosis.
<In a normal immune response, killer T cells are activated by antigen stimulation and selectively eliminate only virus-infected cells, thereby controlling viral replication and promoting the patient’s rapid recovery. However, when killer T cells are nonspecifically overactivated by interleukin-15, they may randomly attack normal cells as well, causing excessive tissue damage and leading to severe disease. Future research may identify diseases in which such nonspecific hyperimmune responses occur, making it possible to develop new drugs to control them>
This study provides crucial clues for understanding the pathogenesis of various immune-related diseases, including severe viral infections, chronic inflammatory disorders, autoimmune diseases, and organ transplant rejection. It also paves the way for developing novel immunoregulatory therapies targeting IL-15 signaling.
Professor Eui-Cheol Shin explained that, “this study shows that killer T cells are not merely defenders—they can transform into ‘nonspecific attackers’ depending on the inflammatory environment. By precisely regulating this abnormal activation, we may be able to develop new treatments for intractable immune diseases.”
This research was published in the journal Immunity on October 31, with Dr. Hoyoung Lee and Ph.D. candidate So-Young Kim as co–first authors.
Title: “TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8⁺ T cells”, DOI: doi.org/10.1016/j.immuni.2025.10.002
The study was supported by the National Research Foundation of Korea (NRF), the Korea Health Industry Development Institute (KHIDI), and the Institute for Basic Science (IBS).
2025.11.06 View 2204 -
AI Finds Urban Commercial Districts Resilient to Climate Risk
< (From left) Integrated M.S.-Ph.D candidate Keonhee Jang, Postdoctoral Researcher Namwoo Kim, Professor Yoonjin Yoon, Researcher Seok-woo Yoon, Postdoctoral Researcher Young-jun Park, (Top) M.S candidate Juneyoung Ro >
KAIST announced on October 29th that its Urban AI Research Institute (Director, Distinguished Professor Yoonjin Yoon of Civil and Environmental Engineering conducted joint research in the field of 'Urban AI' with MIT's Senseable City Lab (Director, Professor Carlo Ratti) and disclosed the results at the 'Smart Life Week 2025' exhibition held at COEX, Seoul, in late September.
KAIST and MIT have been pursuing the 'Urban AI Joint Research Program' to interpret major urban problems using artificial intelligence. At this exhibition, the research results were presented in a form that citizens could directly experience, focusing on three themes: ▲Urban Climate Change, ▲Green Environment, and ▲Data Inclusivity.
Through this collaboration, the two institutions demonstrated that AI technology can expand beyond a tool for calculating urban problems to a new intelligence that promotes social understanding and empathy. They carried out three projects: ▲Urban Heat and Sales, ▲Nature That Heals, Seoul, and ▲Data Sonification.
The first project, 'Urban Heat and Sales,' is a study that analyzes the impact of climate change on urban commercial areas and the small business ecosystem using AI. An AI model was trained on over 300 million data points, including sales and weather for 96 business categories across 426 administrative dong (neighborhoods) in Seoul, to quantify the effect of climatic factors, such as temperature and humidity, on sales by industry type.
The results were visualized into 40,896 'Urban Heat Resilience' indicators, which score how well each region and business category can adapt to and recover from climate change. This allows the level of commercial area resilience to climate risk to be grasped at a glance, showing which areas are strong against temperature risks.
According to the study, for the convenience store sector, 64.7% of the total 426 dong were analyzed as 'climate-neutral areas,' which are relatively stable against climate change, while the remaining 35.3% belong to 'climate-sensitive areas,' which are significantly affected by climate change. This suggests that the operating environment for convenience stores varies significantly by region in terms of climate impact, and the data can be utilized for future location strategy planning from an urban resilience perspective.
< '3D Mesh Structure' that visually represents sales data for 426 regions in Seoul. The height and color of each region indicate the scale of sales. The left shows the distribution of sales in Seoul under actual temperature conditions, and the right shows the sales change predicted by AI when the temperature rises by 5 degrees. >
Visitors to the exhibition could select a region and business type on a real Seoul map and experience a system where the AI predicted sales changes in real-time based on future temperature rise scenarios.
This prediction model is a proprietary technology developed by KAIST, and plans are underway to expand cooperation with other major global cities, such as Boston and London. This research is expected to propose a new direction for establishing opening strategies for small business owners and developing urban climate risk response policies.
< Numerous visitors listening to explanations and experiencing the KAIST-MIT exhibition space >
The second project, 'Nature That Heals, Seoul,' is an extension of MIT's global project 'Feeling Nature' to Seoul. It combines urban environment data (Street View, maps, satellite images, etc.) with citizen survey data to train an AI to estimate the 'psychological green'—the actual psychological experience of green spaces felt by Seoul citizens.
This approach goes beyond simply calculating the area of trees or parks, offering new urban design directions that reflect citizens' emotional resilience and well-being. This research is expected to provide scientific evidence for future Seoul green space policies and locally tailored urban design.
The final project, 'Data Sonification,' is the world's first AI technology that translates over 300 million data points into sounds, like music, to be 'heard.' The AI uses data such as temperature, humidity, and sales to represent information through sound: for example, the pitch rises when the temperature goes up, and the sound lowers when sales decrease. This provides a new sensory experience of 'listening' to urban data through sound instead of sight.
This technology is a prime example of 'Barrier-Free AI' (AI for All), an inclusive AI technology that helps people with visual impairments or children—who may have difficulty accessing visual information—to intuitively understand data.
< A visitor experiencing Data Sonification, the world's first AI technology that converts data into sound >
Man-ki Kim, Chairman of the Seoul AI Hub (Seoul AI Foundation), which sponsored this research, stated, "We have achieved meaningful results by analyzing the urban environment and citizens' lives with artificial intelligence through collaboration with world-class research institutions like KAIST and MIT," adding, "This research has laid the groundwork for understanding urban change from the perspective of citizens and connecting it to policy and daily life."
Director Yoonjin Yoon remarked, "This exhibition demonstrated that artificial intelligence can evolve beyond a technology that merely calculates the city to an intelligence that understands and empathizes with people and the city," and concluded, "We will create data and experiences together with citizens, and collaborate with various cities worldwide to open a more inclusive and sustainable urban future."
This achievement is a global collaborative research project in the AI sector involving the KAIST Urban AI Research Institute and the MIT Senseable City Lab, and was conducted with sponsorship from the Seoul AI Hub.
※Research Results Images/Videos: https://05970c0c.slw-6vy.pages.dev/
2025.10.29 View 2143 -
“AI,” the New Language of Materials Science and Engineering Spoken at KAIST
<(From Left) M.S candidate Chaeyul Kang, Professor Seumgbum Hong, Ph. D candidate Benediktus Madika, Ph.D candidate Batzorig Buyantogtokh, Ph.D candiate Aditi Saha, >
Collaborating authors include Professor Joshua Agar (Drexel University), Professors Chris Wolverton and Peter Voorhees (Northwestern University), Professor Peter Littlewood (University of St Andrews), and Professor Sergei Kalinin (University of Tennessee).
Paper Title: Artificial Intelligence for Materials Discovery, Development, and Optimization
The era has arrived in which artificial intelligence (AI) autonomously imagines and predicts the structures and properties of new materials. Today, AI functions as a researcher’s “second brain,” actively participating in every stage of research, from idea generation to experimental validation.
KAIST (President Kwang Hyung Lee) announced on October 26 that a comprehensive review paper analyzing the impact of AI, Machine Learning (ML), and Deep Learning (DL) technologies across materials science and engineering has been published in ACS Nano (Impact Factor = 18.7). The paper was co-authored by Professor Seungbum Hong and his team from the Department of Materials Science and Engineering at KAIST, in collaboration with researchers from Drexel University, Northwestern University, the University of St Andrews, and the University of Tennessee in the United States.
The research team proposed a full-cycle utilization strategy for materials innovation through an AI-based catalyst search platform, which embodies the concept of a Self-Driving Lab—a system in which robots autonomously perform materials synthesis and optimization experiments.
Professor Hong’s team categorized materials research into three major stages—Discovery, Development, and Optimization—and detailed the distinctive role of AI in each phase:
In the Discovery Stage, AI designs new structures, predicts properties, and rapidly identifies the most promising materials among vast candidate pools.
In the Development Stage, AI analyzes experimental data and autonomously adjusts experimental processes through Self-Driving Lab systems, significantly shortening research timelines.
In the Optimization Stage, AI employs Reinforcement Learning, which identifies optimal conditions through Bayesian Optimization, which efficiently finds superior results with minimal experimentation, to fine-tune designs and process conditions for maximum performance.
In essence, AI serves as a “smart assistant” that narrows down the most promising materials, reduces experimental trial and error, and autonomously optimizes experimental conditions to achieve the best-performing outcomes.
The paper further highlights how cutting-edge technologies such as Generative AI, Graph Neural Networks (GNNs), and Transformer models are transforming AI from a computational tool into a “thinking researcher.” Nonetheless, the team cautions that AI’s predictions are not error-proof and that key challenges persist, such as imbalanced data quality, limited interpretability of AI predictions, and integration of heterogeneous datasets.
To address these limitations, the authors emphasize the importance of developing AI systems capable of autonomously understanding physical principles and ensuring transparent, verifiable decision-making processes for researchers.
The review also explores the concept of the Self-Driving Lab, where AI autonomously designs experimental plans, analyzes results, and determines the next experimental steps—without manual operation by researchers. The AI-Based Catalyst Search Platform exemplifies this concept, enabling robots to automatically design, execute, and optimize catalyst synthesis experiments.
In particular, the study presents cases in which AI-driven experimentation has dramatically accelerated catalyst development, suggesting that similar approaches could revolutionize research in battery and energy materials.
<AI Driving Innovation Across the Entire Cycle of New Material Discovery, Development, and Optimization>
“This review demonstrates that artificial intelligence is emerging as the new language of materials science and engineering, transcending its role as a mere tool,” said Professor Seungbum Hong. “The roadmap presented by the KAIST team will serve as a valuable guide for researchers in Korea’s national core industries including batteries, semiconductors, and energy materials.”
Benediktus Madika (Ph.D. candidate), Aditi Saha (Ph.D. candidate), Chaeyul Kang (M.S. candidate), and Batzorig Buyantogtokh (Ph.D. candidate) from KAIST’s Department of Materials Science and Engineering contributed as co-first authors.
Collaborating authors include Professor Joshua Agar (Drexel University), Professors Chris Wolverton and Peter Voorhees (Northwestern University), Professor Peter Littlewood (University of St Andrews), and Professor Sergei Kalinin (University of Tennessee).
Paper Title: Artificial Intelligence for Materials Discovery, Development, and Optimization
DOI: 10.1021/acsnano.5c04200
This work was supported by the National Research Foundation of Korea (NRF) with funding from the Ministry of Science and ICT (RS-2023-00247245).
2025.10.27 View 2241 -
KAIST Develops Ultrafast Photothermal Process Achieving 3,000 °C in 0.02 Seconds, Boosting Hydrogen Production Efficiency Sixfold
< (from left) Ph.D. candidate Seohak Park, Dr. Jaewan Ahn, Ph.D. candidate Dogyeong Jeon, Prof. Sung-Yool Choi, Prof. Il-Doo Kim, Dr. Chungseong Park, Ph.D. candidate Euichul Shin (top left) Dr. Hamin Shin, Dr. Jun-Hwe Cha i>
The rapid and energy-efficient synthesis of high-performance catalysts is a critical hurdle in advancing clean energy technologies like hydrogen production. Addressing this challenge, a research team at KAIST has now developed a novel platform technology that utilizes a 0.02-second flash of light to generate an ultrahigh temperature of 3,000 °C, enabling the highly efficient synthesis of catalysts. This breakthrough process reduces energy consumption by more than a thousandfold compared to conventional methods while increasing hydrogen production efficiency by up to six times, marking a significant step toward the commercialization of clean energy.
KAIST (President Kwang Hyung Lee) announced on October 20 that a joint research team, co-led by Professor Il-Doo Kim from the Department of Materials Science and Engineering and Professor Sung-Yool Choi from the School of Electrical Engineering, has developed a “direct-contact photothermal annealing” platform. This technique synthesizes high-performance nanomaterials through brief exposure to intense light, generating a transient temperature of 3,000 °C in just 0.02 seconds.
Using this intense photothermal energy, the researchers successfully converted chemically inert nanodiamond (ND) precursors into highly conductive and catalytically active carbon nanoonions (CNOs).
More impressively, the method simultaneously functionalizes the surface of the newly formed CNOs with single atoms. This integrated, one-step process restructures the support material and embeds catalytic functionality in a single light pulse, representing a significant innovation in catalyst synthesis.
CNOs, composed of concentric graphitic shells, are ideal catalyst supports due to their high conductivity, large specific surface area, and chemical stability. However, traditional CNO synthesis has been hindered by complex, multi-step post-processing required to load metal catalysts and by reliance on energy-intensive, time-consuming thermal treatments that limit scalability.
< Schematic Illustration of the Limitations of Conventional Thermal-Radiation Synthesis and the Carbon Nano-Onion Conversion via Direct-Contact Photothermal Treatment >
To overcome these limitations, the KAIST team leveraged the photothermal effect. They devised a method of mixing ND precursors with light-absorbing carbon black (CB) and applying an intense pulse from a xenon lamp. This approach triggers the transformation of NDs into CNOs in just 0.02 seconds, a phenomenon validated by molecular dynamics simulations.
A key innovation of this platform is the simultaneous synthesis of CNOs and functionalization of single-atom catalysts (SACs). When metal precursors, such as platinum (Pt), are included in the mixture, they decompose and anchor onto the surface of the nascent CNOs as individual atoms. The subsequent rapid cooling prevents atomic aggregation, resulting in a perfectly integrated one-step process for both synthesis and functionalization. The team has successfully synthesized eight different high-density SACs, including platinum (Pt), cobalt (Co), and nickel (Ni). The resulting Pt-CNO demonstrated a sixfold enhancement in hydrogen evolution efficiency compared to conventional catalysts, achieving high performance with significantly smaller quantities of precious metals. This highlights the technology's potential for scalable and sustainable hydrogen production.
“We have developed, for the first time, a direct-contact photothermal annealing process that reaches 3,000°C in under 0.02 seconds,” said Professor Il-Doo Kim. “This ultrafast synthesis and single-atom functionalization platform reduces energy consumption by more than a thousandfold compared to traditional methods. We expect it to accelerate the commercialization of technologies in hydrogen energy, gas sensing, and environmental catalysis.”
The study’s first authors are Dogyeong Jeon (Ph.D. candidate, Department of Materials Science and Engineering, KAIST), Dr. Hamin Shin (an alumnus of the Department of Materials Science and Engineering and a current postdoctoral researcher at ETH Zurich), and Dr. Jun-Hwe Cha (an alumnus of the School of Electrical Engineering, now at SK hynix). Professors Sung-Yool Choi and Il-Doo Kim are the corresponding authors.\
< Inside Cover Image of the September Issue of ACS >
The research was published as a Supplementary Cover Article in the September issue of ACS Nano, a leading international journal of the American Chemical Society (ACS).
※ Paper title: “Photothermal Annealing-Enabled Millisecond Synthesis of Carbon Nanoonions and Simultaneous Single-Atom Functionalization,” DOI: 10.1021/acsnano.5c11229
This research was supported by the Global R&D Infrastructure Program and the Leading Research Center Program of the National Research Foundation of Korea (NRF), funded by the Ministry of Science and ICT, and the Nano Convergence Technology Center’s Semiconductor–Battery Interfacing Platform Development Project.
2025.10.21 View 2301 -
KAIST Launches Student Led ESG Research Platform with Brand Revenue
KAIST (President Kwang Hyung Lee) announced on the 19th of October that it is launching a new action-oriented ESG program, 'PDSP (Problem Definition to Solution Program),' which returns brand revenue to students to support research aimed at solving social problems. Brand revenue refers to profits from the sale of branded products, such as 'Nubjuk-i,' and the brand shop that KAIST operates near the campus's duck pond.
This initiative is the first model to concretize KAIST's brand value and social responsibility through a student-centric approach, serving as an innovative starting point that connects 'research–startup–social contribution.'
The project is funded by dividends from Brand KAIST, a subsidiary of KAIST Holdings (CEO Hyunmin Bae), led by co-CEOs Hyun Jung Suk and Byeongjun Bok (CEO of KAI Patent Law Firm, and KAIST Industrial Design alumni).
By reinvesting brand revenue into student research activities, KAIST aims to implement a KAIST-style virtuous cycle ESG structure: 'Brand->Revenue->Student->Social Contribution.'
PDSP is a research program where KAIST undergraduate students voluntarily form teams to explore social and technological problems and propose solutions. The program name, 'Problem Definition to Solution Program,' signifies that students directly define the problem and design the solution, aiming to become a practical research platform that connects learned knowledge to solving social issues.
Through the PDSP, KAIST is expanding the concept of ESG beyond Environment, Society, and Governance to 'Practicing Social Responsibility through Education and Science.'
The process of students proactively defining social problems and proposing solutions is itself a form of ESG value realization, and KAIST seeks to build a science and technology-based, action-oriented ESG model through this.
The PDSP operates with two research tracks: Deep Tech and ESG. The 'Deep Tech Track' supports fundamental technology research that will lead future industries, leveraging KAIST's advanced science and technology capabilities in areas such as Artificial Intelligence (AI), semiconductors, robotics, biotechnology, new materials, and energy. The 'ESG Track' focuses on research on social issues such as climate change, carbon neutrality, and aging, concentrating on realizing a sustainable society through science and technology.
<KAIST PDSP (Problem Definition to Solution Program) Poster>
This program is regarded not merely as an idea contest but as a 'student-led Deep Tech incubation program' that promotes substantial technological innovation originating from research labs.
Participation is open to approximately 20 teams, each composed of three to five undergraduate students. Each team can choose to apply for either the Deep Tech Track or the ESG Track. A maximum of 1.5 million KRW in research activity expenses will be provided per team for three months, with the funding executed according to KAIST's internal research project standards. Applications are accepted through the KAIST portal site from September 29 until midnight on November 5. Selected teams, after being reviewed by an evaluation committee, will go through stages including orientation, interim check, and performance presentation.
Hyeonmin Bae, CEO of KAIST Holdings (Professor of Electrical Engineering), stated, "The PDSP will be the starting point for KAIST-style autonomous research culture where students define problems and design solutions themselves," adding, "We plan to actively consider providing initial investments and commercialization support for outstanding research teams to develop their ideas into startups."
Hyeong-Jeong Suk, CEO of Brand KAIST (Professor of Industrial Design), said, "This program, where Brand KAIST's revenue is reinvested into student research, shows that the KAIST brand is evolving beyond a mere symbol to a platform for creating social value. I believe the true power of the KAIST brand lies in students creating new change that bridges technology and society through creative research."
A student who submitted an application for the program commented, "I wanted to explore social topics like environmental issues or technological inequality through research, and I am excited that this program offers such an opportunity," adding, "I feel a sense of pride as a KAIST student to be able to give back the knowledge I've gained to society."
KAIST President Kwang Hyung Lee emphasized, "Creating a co-prosperity innovation model that returns the value generated by the KAIST brand to our students is also KAIST's strength," and "I hope that the problems defined by the students themselves will contribute to the progress of humanity, and that creative research will become the driving force for social change."
Since its establishment in 1971, leading South Korea's scientific and technological development and industrial innovation, KAIST is realizing the 'virtuous cycle of brand value' through its PDSP, presenting a new ESG paradigm that combines student-led social contribution and technological innovation.
2025.10.20 View 1601 -
Chemobiological Platform Enables Renewable Conversion of Sugars into Core Aromatic Hydrocarbons of Petroleum
<(From Left) Professor Sun Kyu Han, Ph.D candidate Tae Wan Kim, Professor Kyeong Rok Choi, Professor Sang Yup Lee>
With growing concerns over fossil fuel depletion and the environmental impacts of petrochemical production, scientists are actively exploring renewable strategies to produce essential industrial chemicals. A collaborative research team—led by Distinguished Professor Sang Yup Lee, Senior Vice President for Research, from the Department of Chemical and Biomolecular Engineering, together with Professor Sunkyu Han from the Department of Chemistry at the Korea Advanced Institute of Science and Technology (KAIST)—has developed an integrated chemobiological platform that converts renewable carbon sources such as glucose and glycerol into oxygenated precursors, which are subsequently deoxygenated in the same solvent system to yield benzene, toluene, ethylbenzene, and p-xylene (BTEX), which are fundamental aromatic hydrocarbons used in fuels, polymers, and consumer products.
<Figure 1. Schematic representation of the chemobiological synthesis of BTEX from glucose or glycerol in Escherichia coli>
From Sugars to Aromatic Hydrocarbons of Petroleum
The researchers designed four metabolically engineered strains of Escherichia coli, each programmed to produce a specific oxygenated precursor—phenol, benzyl alcohol, 2-phenylethanol, or 2,5-xylenol. These intermediates are generated through tailored genetic modifications, such as deletion of feedback-regulated enzymes, overexpression of pathway-specific genes, and introduction of heterologous enzymes to expand metabolic capabilities.
During fermentation, the products were continuously extracted into the organic solvent isopropyl myristate (IPM). Acting as a dual-function solvent, IPM not only mitigated the toxic effects of aromatic compounds on cell growth but also served directly as the reaction medium for downstream chemical upgrading. By eliminating the need for intermediate purification, solvent exchange, or distillation, this solvent-integrated system streamlined the conversion of renewable feedstocks into valuable aromatics.
Overcoming Chemical Barriers in An Unconventional Solvent
A central innovation of this work lies in adapting chemical deoxygenation reactions to function efficiently within IPM—a solvent rarely used in organic synthesis. Traditional catalysts and reagents often proved ineffective under these conditions due to solubility limitations or incompatibility with biologically derived impurities.
Through systematic optimization, the team established mild and selective catalytic strategies compatible with IPM. For example, phenol was successfully deoxygenated to benzene in up to 85% yield using a palladium-based catalytic system, while benzyl alcohol was efficiently converted to toluene after activated charcoal pretreatment of the IPM extract. More challenging transformations, such as converting 2-phenylethanol to ethylbenzene, were achieved through a mesylation–reduction sequence adapted to the IPM phase. Likewise, 2,5-xylenol derived from glycerol was converted to p-xylene in 62% yield via a two-step reaction, completing the renewable synthesis of the full BTEX spectrum.
A Sustainable, Modular Framework
Beyond producing BTEX, the study establishes a generalizable framework for integrating microbial biosynthesis with chemical transformations in a continuous solvent environment. This modular approach reduces energy demand, minimizes solvent waste, and enables process intensification—key factors for scaling up renewable chemical production.
The high boiling point of IPM (>300 °C) simplifies product recovery, as BTEX compounds can be isolated by fractional distillation while the solvent is readily recycled. Such a design is consistent with the principles of green chemistry and the circular economy, providing a practical alternative to fossil-based petrochemical processes.
Toward A Carbon-Neutral Future
Dr. Xuan Zou, the first author of this paper, explaind, “By coupling the selectivity of microbial metabolism with the efficiency of chemical catalysis, this platform establishes a renewable pathway to some of the most widely used building blocks in the chemical industry. Future efforts will focus on optimizing metabolic fluxes, extending the platform to additional aromatic targets, and adopting greener catalytic systems.”
In addition, Distinguished Professor Sang Yup Lee noted “As the global demand for BTEX and related chemicals continues to grow, this innovation provides both a scientific and industrial foundation for reducing reliance on petroleum-based processes. It marks an important step toward lowering the carbon footprint of the fuel and chemical sectors while ensuring a sustainable supply of essential aromatic hydrocarbons.”
This research was supported by the Development of Platform Technologies of Microbial Cell Factories for the Next-Generation Biorefineries Project (2022M3J5A1056117) and the Development of Advanced Synthetic Biology Source Technologies for Leading the Biomanufacturing Industry Project (RS-2024-00399424), funded by the National Research Foundation supported by the Korean Ministry of Science and ICT. This study was published in the latest issue of the Proceedings of the National Academy of Sciences of the United States of America (PNAS).
2025.10.13 View 2171