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KAIST Researchers Receive Awards at the 13th Asian Congress on Biotechnology
(From left: Seon Young Park, Dr. So Young Choi, and Yoojin Choi) Researchers in the laboratory of KAIST Distinguished Professor Sang Yup Lee from the Department of Chemical and Biomolecular Engineering swept awards at the 13th Asian Congress on Biotechnology held in Thailand last month. The conference awarded a total of eight prizes in the areas of best research and best poster presentation. This is an exceptional case in which members of one research team received almost half of the awards at an international conference. Dr. So Young Choi received the Best Research Award, while Ph.D. candidates Yoojin Choi and Seon Young Park each received the Best Poster Presentation Award at the conference held in Khon Kaen, Thailand from July 23 to 27. The Asian Congress on Biotechnology is an international conference in which scientists and industry experts in Asia and from around the world gather to present recent research findings in the field of biotechnology. At the conference, around 400 researchers in biotechnology from 25 countries, including Korea, gathered to present and discuss various research findings under the theme of “Bioinnovation and Bioeconomy.” Distinguished Professor Sang Yup Lee attended the conference to give the opening plenary lecture on the topic of ‘Systems Strategies in Biotechnology.’ Professor Lee announced, “I have attended international conferences with students for the last 20 years, but this is the first in which my team received three awards at an international conference that only honors a total of eight awards, three for Best Research and five for Best Presentation.” Dr. Choi presented research results on poly (lactate-co-glycolate) (PLGA) synthesis through a biological method using micro-organisms and received the Best Research Award. PLGA is a random copolymer of DL-lactic and glycolic acids and is a biopolymer widely used for biomedical applications. PLGA is biodegradable, biocompatible, and nontoxic, and thus has been approved by the US Food and Drug Administration (FDA) for its use in implants, drug delivery, and sutures. Dr. Choi’s research was deemed to be innovative for synthesizing PLGA from glucose and xylose in cells through metabolic engineering of E.Coli. Dr. Choi received her Ph.D. under the supervision of Distinguished Professor Lee this February and is currently conducting post-doc research. Ph.D. candidate Choi presented her research on the use of recombinant E.Coli for the biological synthesis of various nanoparticles and received the Best Poster Presentation award. Choi used recombinant E.Coli-expressing proteins and peptides that adsorb to heavy metals to biologically synthesize diverse metal nanoparticles such as single-nanoparticle including gold and silver, quantum dots, and magnetic nanoparticles for the first time. The synthesized nanoparticles can be used in the fields of bio-imaging, diagnosis, environment, and energy. Ph.D. candidate Park, who also received the Best Poster Presentation award, synthesized and increased production of astanxanthin, a strong antioxidant found in nature, in E.Coli using metabolic engineering. Astanxanthin is a carotenoid pigment found in salmon and shrimp that widely used in health products and cosmetics.
2017.08.01
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KAIST Professors Sweep the Best Science and Technology Award
(Distinguished Professors Sang Yup Lee (left) and Kyu-Young Whang) Distinguished Professors Sang Yup Lee from the Department of Chemical and Biomolecular Engineering and Kyu-Young Whang of the College of Computing were selected as the winners of the "2017 Korea Best Science and Technology Award" by the Ministry of Science, ICT and Future Planning (MSIP) and the Korea Federation of Science and Technology Societies. The award, which was established in 2003, is the highest honor bestowed to the two most outstanding scientists in Korea annually. This is the first time that KAIST faculty members have swept the award since its founding. Distinguished Professor Lee is renowned for his pioneering studies of system metabolic engineering, which produces useful chemicals by utilizing microorganisms. Professor Lee has developed a number of globally-recognized original technologies such as gasoline production using micro-organisms, a bio-butanol production process, microbes for producing nylon and plastic raw materials, and making native-like spider silk produced in metabolically engineering bacterium which is stronger than steel but finer than human hair. System metabolism engineering was also selected as one of the top 10 promising technologies in the world in 2016 by the World Economic Forum. Selected as one of the world’s top 20 applied bioscientists in 2014 by Nature Biotechnology, he has many ‘first’ titles in his academic and research careers. He was the first Asian to win the James Bailey Award (2016) and Marvin Johnson Award (2012), the first Korean elected to both the US National Academy of Science (NAS) and the National Academy of Engineering (NAE) this year. He is the dean of KAIST institutes, a multi and interdisciplinary research institute at KAIST. He serves as co-chair of the Global Council on Biotechnology and as a member of the Global Future Council on the Fourth Industrial Revolution at the World Economic Forum. Distinguished Professor Whang, the first recipient in the field of computer science in this award, has been recognized for his lifetime achievement and contributions to the development of the software industry and the spreading of information culture. He has taken a pioneering role in presenting novel theories and innovative technologies in the field of database systems such as probabilistic aggregation, multidimensional indexing, query, and database and information retrieval. The Odysseus database management system Professor Hwang developed has been applied in many diverse fields of industry, while promoting the domestic software industry and its technical independence. Professor Hwang is a fellow at the American Computer Society (ACM) and life fellow at IEEE. Professor Whang received the ACM SIGMOD Contributions Award in 2014 for his work promoting database research worldwide, the PAKDD Distinguished Contributions Award in 2014, and the DASFAA Outstanding Contributions Award in 2011 for his contributions to database and data mining research in the Asia-Pacific region. He is also the recipient of the prestigious Korea (presidential) Engineering Award in 2012.
2017.07.03
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Top 10 Emerging Technologies of 2017
The World Economic Forum’s Expert Network and Global Future Councils in collaboration with Scientific American and its Board of Advisors announced the top 10 emerging technologies of 2017 on June 26 in Dalian, China where the 2017 Summer Davos Forum is being held. Each technology was chosen for its potential to improve lives, transform industries, and safeguard the planet. The KAIST delegation, headed by President Sung-Chul Shin, is participating in the forum’s diverse activities including IdeasLab and GULF (Global University Leaders Forum). KAIST is the only Korean representative participating in the IdeasLab. KAIST Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering, director of KAIST Institute, has served as a committee member of the Global Agenda Council on Emerging Technologies since 2012 and Global Future Council on the Fourth Industrial Revolution. He also chairs the Global Future Council on Biotechnologies. Professor Lee said, “Very diverse technological breakthroughs were proposed for the final list of candidates. We made the final selections through very in-depth discussion with experts in each field. We focused on the technologies which have a level of maturity that will enable them to be adopted widely within three to five years." The top 10 emerging technologies are (courtesy from https:// www.weforum.org/agenda/2017/06/these-are-the-top-10-emerging-technologies-of-2017): 2017 10대 기술. 1. Liquid biopsies Liquid biopsies mark a step forward in the fight against cancer. First, they are an alternative where traditional tissue-based biopsies are not possible. Second, they provide a full spectrum of information compared to tissue samples, which only reflect the information available in the sample. Lastly, by homing in on circulating-tumor DNA (ctDNA), genetic material that routinely finds its way from cancer cells into the bloodstream, disease progression or resistance to treatment can be spotted much faster than otherwise relying on symptoms or imaging. 2. Harvesting clean water from air The ability to extract clean water from air is not new, however existing techniques require high moisture levels and a lot of electricity. This is changing. A team from MIT and University of California, Berkeley has successfully tested a process using porous crystals that convert the water using no energy at all. 3. Deep learning for visual tasks Computers are beginning to recognize images better than humans. Thanks to deep learning, an emerging field of artificial intelligence, computer-vision technologies are increasingly being used in applications as diverse as driving autonomous vehicles, medical diagnostics, damage assessment for insurance claims, and monitoring water levels and crop yield. 4. Liquid fuels from sunshine Can we mimic the humble leaf to create artificial photosynthesis to generate and store energy? The prospects are looking increasingly positive. The answer lies in using sunlight-activated catalysts to split water molecules into water and hydrogen, and then using the same hydrogen to convert CO2 into hydrocarbons. 5. The Human Cell Atlas An international collaboration aimed at deciphering the human body, called the Human Cell Atlas, was launched in October 2016. The project aims to identify every cell type in every tissue; learn exactly which genes, proteins, and other molecules are active in each type, and the processes which control that activity. 6. Precision farming The Fourth Industrial Revolution is providing farmers with a new set of tools to boost crop yield and quality while reducing water and chemical use. Sensors, robots, GPS, mapping tools, and data-analytics software are all being used to customize the care that plants need. 7. Affordable catalysts for green vehicles Progress is being made on a promising zero-emission technology, the hydrogen-fed fuel cell. Progress to date has been stymied by the high price of catalysts which contain platinum. However, much progress has been made in reducing reliance on this rare and expensive metal, and the latest developments involve catalysts that include no platinum, or in some cases no metal at all. 8. Genomic vaccines Vaccines based on genes are superior to more conventional ones in a number of ways. They are faster to manufacture, which is crucial during violent outbreaks. Compared to manufacturing proteins in cell cultures or eggs, producing genetic material should also be simpler and less expensive. 9. Sustainable design of communities Applying green construction to multiple buildings at once has the potential to revolutionize the amount of energy and water we consume. Sending locally-generated solar power to a smart microgrid could reduce electricity consumption by half and reduce carbon emissions to zero if a project currently under development at the University of California at Berkeley goes according to plan. 10. Quantum computing Quantum computers’ almost limitless potential has only ever been matched by the difficulty and cost of their construction. This explains why today the small ones that have been built have not yet managed to exceed the power of supercomputers. But progress is being made and in 2016 the technology firm IBM provided public access to the first quantum computer in the cloud.
2017.06.28
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The Embassy Day Builds the Global Presence of KAIST
(Photo caption: Diplomats and KAIST faculty pose at the Embassy Day KAIST hosted on June 23.) KAIST is stepping up its initiative for building global competitiveness. The Embassy Day hosted on June 23 will be a stepping stone to diversify its channels for promoting the global presence of KAIST. KAIST invited the foreign diplomatic corps from Seoul to share their successful journey to emerge as the world-class university. The event featured KAIST’s research highlights, academic experiences, and global environment through presentations by faculty and students. KAIST President Sung-Chul Shin said in his welcoming speech that he hopes for brains from around the world to come to KAIST and believes this event will serve as an opportunity to spread the global reputation of KAIST more widely. President Shin, who took office in March, ambitiously hosted this event for the first time, saying, “We didn’t expect this big of a response from the diplomats. The presence of this leading group of diplomats reflects how KAIST’s reputation has blossomed.” Nearly 100 diplomats from 65 countries attended the event held at the Grand Hyatt Seoul. Among the participants were ambassadors from 33 countries including Australian Amb. James Choi, Canadian Amb. Eric Walsh, and German Amb. Stephan Auer, reflecting the growing interest in the advancements in science and technology education and innovation in KAIST. The entire leadership team of KAIST turned out for the event including Provost O-Ok Park, Associate Vice President of the International Office Jay Hyung Lee, and Dean of Admissions Hayong Shin to provide an update on KAIST activities as well as admission policies, and make a new network with the foreign envoys. At the event, KAIST presented some of its latest research highlights that are gaining international acclaim. Professor Jun-ho Oh, director at the Humanoid Robot Research Center talked on the short history of the development of the KAIST humanoid robot, HUBO, which won the DARPA Robotics Challenge (DRC) in 2015. Distinguished Professor Sang-Yup Lee, dean of the KAIST Institute, which is the center of multidisciplinary research projects in KAIST, made a presentation on advances in metabolic engineering. In addition, Professor David Helfman of the Department of Biological Science shared his research on breast cancer and metastasis. Foreign students and faculty shared their experiences on becoming part of the KAIST community during the testimonial session. In particular, the story of Professor Jean-Charles Bazin of the Graduate School of Culture Technology was quite moving. Originally from France, Professor Bazin talked about his unique career path, starting as an exchange student at KAIST before settling down as a faculty member here. He cited the high caliber group of faculty as one of the reasons he completed his Ph.D. at KAIST. “Most of the faculty members are from top institutions in the US, Europe, and around the world, so they have very resourceful contacts with distinguished researchers and scholars abroad. That helped me make up my mind to choose KAIST,” he said. Currently, 179 foreign faculty and researchers from over 31 countries, representing 8.7% of the total faculty, are working at KAIST. Also, 710 foreign students from 86 countries, representing about 8% of the total students, are now studying at KAIST. President Shin continued, “In this complex global era, brains follow the best path to where they can reach their potential. KAIST is now gaining tremendous strength by becoming a magnet for talents from around the world. We would like to recruit these brains to create new knowledge with a global impact. Then we will become true global university with supremacy in research and education. President Shin said KAIST is gearing up for another round of innovation initiatives in education, convergence research, technology commercialization, future strategies, and globalization. He emphasized that globalization of the campus is a must for building up our global competitiveness. (Photo caption from the top: President Shin greets participant. Professor Oh explains the functions of the HUBO. Professor Helfman presents on his research of breast cancer and metastasis. KAIST a capella group showcases singing skills at the event. Participants meet and greet at the Embassy Day.)
2017.06.23
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KAIST to Participate in the Summer Davos Forum
KAIST will participate in the 2017 Summer Davos Forum in Dalian, China from June 27 to 29. The Summer Davos Forum with the official title “Annual Meeting of New Champions” is an annual international meeting co-hosted by China and the World Economic Forum (WEF) to address global issues which has been held since 2007. Focusing on this year’s theme ‘Achieving Inclusive Growth in the Fourth Industrial Revolution,’ science and technology experts from 90 different countries will participate in various sessions to present on and discuss pending global innovative issues. KAIST is to be the only Korean university to run ‘IdeasLab,’ in which researchers will introduce current research trends and discuss ideas with global leaders. This is the sixth year for KAIST to run IdeasLab. This year’s IdeasLab has the theme ‘Materials of the Future,’ and will include presentations and discussions on materials developed at KAIST which could lead the Fourth Industrial Revolution. President Sung-Chul Shin, the chairman of the session, will first introduce the current status of KAIST and IdeasLab, followed by a presentation of cutting-edge integrated research findings by KAIST professors. President Shin will also participate in various sessions organized by the Global University Leaders Forum (GULF) as discussion leader. President Shin is the only Korean member of GULF, a community comprised of the presidents of the world’s top 27 universities. Other members include the presidents of the University of Oxford and the University of Cambridge in the U.K., MIT, Harvard, Stanford, and Columbia Universities in the US, and the University of Tokyo in Japan. Further, President Shin will participate in a strategy session for inclusive growth in the era of the Fourth Industrial Revolution and a meeting with the WEF directors. The Dean of KAIST Institutes, Distinguished Professor Sang Yup Lee from the Chemical and Biomolecular Engineering Department, who has been invited to the Davos Forum and Summer Davos Forum for the last 15 years, is to present in the ‘Future of Life: Medicine’ session to introduce advancements in traditional medicine through systems biology such as his research on microbiomes (gut microbes). Professor Lee, as the chair of the Global Future Council on Biotechnology at the WEF, and committee member of the Annual Meeting of the Global Future Councils on the Fourth Industrial Revolution, is to participate in various bio-sessions and the Fourth Industrial Revolution banquet session to lead the discussions. President Shin said, “KAIST has been sharing global research findings with global leaders through IdeasLab at the Davos Forum for the past six years and it has always been well received.” He continued, “The forum will be the place for in-depth discussion on the technological changes that accompany the Fourth Industrial Revolution and human-centered development plan, as well as introducing innovative research and integrated research findings from KAIST.” This year’s speakers include Li Keqiang, the current Premier of the State Council of China; Guo Ping, the rotating C.E.O. of Huawei; and Ya-Qin Zhang, the President of Baidu, a company leading technological innovation in various fields such as robotics and autonomous vehicles. Two thousand distinguished guests in politics, administration, finance, and academia from 90 countries are to participate in the meeting.
2017.06.21
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Bio-based p-Xylene Oxidation into Terephthalic Acid by Engineered E.coli
KAIST researchers have established an efficient biocatalytic system to produce terephthalic acid (TPA) from p-xylene (pX). It will allow this industrially important bulk chemical to be made available in a more environmentally-friendly manner. The research team developed metabolically engineered Escherichia coli (E.coli) to biologically transform pX into TPA, a chemical necessary in the manufacturing of polyethylene terephthalate (PET). This biocatalysis system represents a greener and more efficient alternative to the traditional chemical methods for TPA production. This research, headed by Distinguished Professor Sang Yup Lee, was published in Nature Communications on May 31. The research team utilized a metabolic engineering and synthetic biology approach to develop a recombinant microorganism that can oxidize pX into TPA using microbial fermentation. TPA is a globally important chemical commodity for manufacturing PET. It can be applied to manufacture plastic bottles, clothing fibers, films, and many other products. Currently, TPA is produced from pX oxidation through an industrially well-known chemical process (with a typical TPA yield of over 95 mol%), which shows, however, such drawbacks as intensive energy requirements at high temperatures and pressure, usage of heavy metal catalysts, and the unavoidable byproduct formation of 4-carboxybenzaldehyde. The research team designed and constructed a synthetic metabolic pathway by incorporating the upper xylene degradation pathway of Pseudomonas putida F1 and the lower p-toluene sulfonate pathway of Comamonas testosteroni T-2, which successfully produced TPA from pX in small-scale cultures, with the formation of p-toluate (pTA) as the major byproduct. The team further optimized the pathway gene expression levels by using a synthetic biology toolkit, which gave the final engineered E. coli strain showing increased TPA production and the complete elimination of the byproduct. Using this best-performing strain, the team designed an elegant two-phase (aqueous/organic) fermentation system for TPA production on a larger scale, where pX was supplied in the organic phase. Through a number of optimization steps, the team ultimately achieved production of 13.3 g TPA from 8.8 g pX, which represented an extraordinary yield of 97 mol%. The team has developed a microbial biotechnology application which is reportedly the first successful example of the bio-based production of TPA from pX by the microbial fermentation of engineered E. coli. This bio-based TPA technology presents several advantages such as ambient reaction temperature and pressure, no use of heavy metals or other toxic chemicals, the removable of byproduct formation, and it is 100% environmentally compatible. Professor Lee said, “We presented promising biotechnology for producing large amounts of the commodity chemical TPA, which is used for PET manufacturing, through metabolically engineered gut bacterium. Our research is meaningful in that it demonstrates the feasibility of the biotechnological production of bulk chemicals, and if reproducible when up-scaled, it will represent a breakthrough in hydrocarbon bioconversions.” Ph.D. candidate Zi Wei Luo is the first author of this research (DOI:10.1038/ncomms15689).The research was supported by the Intelligent Synthetic Biology Center through the Global Frontier Project (2011-0031963) of the Ministry of Science, ICT & Future Planning through the National Research Foundation of Korea. Figure: Biotransformation of pX into TPA by engineered E. coli. This schematic diagram shows the overall conceptualization of how metabolically engineered E. coli produced TPA from pX. The engineered E. coli was developed through reconstituting a synthetic metabolic pathway for pX conversion to TPA and optimized for increased TPA yield and byproduct elimination. Two-phase partitioning fermentation system was developed for demonstrating the feasibility of large-scale production of TPA from pX using the engineered E. coli strains, where pX was supplied in the organic phase and TPA was produced in the aqueous phase.
2017.06.05
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2017 KAIST Research Day Honors Professor Hoon Sohn
The 2017 KAIST Research Day recognized Professor Hoon Sohn of the Department of Civil and Environmental Engineering as Research Grand Prize Awardee in addition to the 10 most distinguished research achievements of the past year. The Research Grand Prize recognizes the professor whose comprehensive research performance evaluation indicator is the highest over the past five years. The indicator combines the factors of the number of research contracts, IPR, royalty income, as well as research overhead cost inclusion. During the ceremony, which was held on May 23, Professor Jun-Ho Oh of the Department of Mechanical Engineering and Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering also won the Best Research Award. The two professors had the best scores when evaluating their research performance for one-year periods. Meanwhile, the Research Innovation Award went to Professor YongKeun Park of the Department of Physics. The Research Innovation Award scores the factors of foreign patent registration, contracts of technological transfer and income from technology fees, technology consultations, and startups and selected Professor Park as the top winner. Professors Yong Hee Lee of the Department of Physics and Jonghwa Shin of the Department of Material Science won the Convergence Research Award. The Convergence Research Award recognizes the most outstanding research team who created innovative research results for a year. After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.” the Research Day ceremony, KAIST also presented the ten most distinguished research achievements made by KAIST professors during the last year as follows (Click): ▲ Commercialization of 3D Holographic Microscopy by Professor YongKeun Park of the Department of Physics ▲ Designer Proteins with Chemical Modifications by Professor Hee-Sung Park of the Department of Chemistry ▲ Lanthanum-Catalyzed Synthesis of Microporous 3D Graphene-Like Carbons in a Zeolite Template by Professor Ryong Ryoo of the Department of Chemistry ▲ Complete Prevention of Blood Loss by Self-Sealing Hemostatic Needles by Professor Haeshin Lee of the Department of Chemistry ▲ An Immunological Mechanism for the Contribution of Commensal Microbiota Against Herpes Simplex Virus Infection in Genital Mucosa by Heung Kyu Lee of the Graduate School of Medical Science and Engineering ▲ Development of a Pulse-Echo Laser Ultrasonic Propagation Imaging System by Professor Jung-Ryul Lee of the Department of Aerospace Engineering ▲ Bi-refractive Stereo Imaging for Single-Shot Depth Acquisition by Professor Min H. Kim of the School of Computing ▲ Development of Environment Friendly Geotechnical Construction Material Using Biopolymer by Professor Gye-Chun Cho of the Department of Civil and Environmental Engineering ▲ Protein Delivery Via Engineered Exosomes by Professor Chulhee Choi of the Department of Bio and Brain Engineering ▲ Hot Electron Detection Under Catalytic Reactions by Professor Jeong Young Park of the Graduate School of EEWS. After the ceremony, President Chen Shiyi of the Southern University of Science and Technology gave a distinguished lecture on the “Global & Entrepreneurial Universities for the Age of the Fourth Industrial Revolution.” (Photo:President Shin poses with the 2017 KAIST Research Grand Prize Winner Professor Hoon Sohn on May 23.)
2017.05.23
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Distinguished Professor Lee Elected to the NAS
Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering was elected as a foreign associate to the US National Academy of Sciences (NAS) on May 2. The National Academy of Sciences elected 84 new members and 21 foreign associates in recognition of their distinguished and continuing achievements in their original research. Election to the Academy is widely regarded as one of the highest honors that a scientist can receive. Professor Lee was also elected in 2010 as a member of the US National Academy of Engineering (NAE) for his leadership in microbial biotechnology and metabolic engineering, including the development of fermentation processes for biodegradable polymers and organic acids. Until 2016, there are only 12 people worldwide who are foreign associates of both NAS and NAE. He is the first Korean elected to both prestigious academies, the NAS and the NAE in the US. Professor Lee is currently the dean of KAIST Institutes, the world leading institute for multi-and interdisciplinary research. He is also serving as co-chair of the Global Council on Biotechnology and member of the Global Future Council on the Fourth Industrial Revolution, the World Economic Forum.
2017.05.16
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Policy Debate Series for Industry 4.0
(Photo caption: President Shin takes the podium as the first speaker of a year-long monthly policy dabate series on Industry 4.0 on May 11.) KAIST will kick off a monthly policy debate series on Industry 4.0 every Thursday from May 11 at the Startup KAIST building. The year-long series, featuring professors from key technology fields associated with Industry 4.0, is designed to help policy makers from government, industry, and research institutes respond better to the ramifications that Industry 4.0 brings about in each sector. The series will help them establish the vision and strategy that will work for the new industrial environment to take the lead in the new industrial era. Twelve professors, including President Sung-Chul Shin, from departments that are researching emerging technologies will speak on the megatrend of new technology, while facilitating debates and Q& A sessions with participants. The participants will include officials from the government complexes in Sejong and Daejeon cities, government-funded research institutes in Daejeon, and businessmen, among others. For registration, please go to https://startup.kaist.ac.kr/register. Schedule Speaker Theme May 11 President Sung-Chul Shin Challenges and Innovations of KAIST in the Era of Industry 4.0 June 8 Professor Jonghwan Kim Machine Intelligence and Deep Learning July 6 Professor Jun Ho Oh Robot Technology and the Future Aug. 3 Professor Hyunchul Shim Unmanned Vehicle Technology and Industry 4.0 Sept. 7 Professor Hawoong Jeong Complex Systems and Data Science Oct. 12 Professor Yongdae Kim Technology, Policy, and the Fostering of Talents: Industry 4.0 and Information Protection Nov. 9 Professor Sang Yup Lee The Role of Biotechnology in Industry 4.0 Dec. 7 Professor Meeyoung Cha AI-Based Research for Fake News Detection 2018 Jan. 4 Professor Joungho Kim Innovation for the Korean Semiconductor Industry: Kim’s Law Feb. 8 Professor Jaekyun Moon Education for Industry 4.0 March 8 Professor Sang Kil Cha Artificial Intelligence Cyber Warfare: Its Present and Future April 5 Professor Jaeseung Jeong The Future of Brain Engineering and Artificial Intelligence
2017.05.08
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Global Workshop on the Risks of Emerging Technologies
The Center for Science, Policy and Society (CSPS) at the Graduate School of Science and Technology Policy of KAIST will host the 2017 Global Expert Workshop on the Risks of Emerging Technologies Driving the Fourth Industrial Revolution March 17-18 at the Plaza Hotel in Seoul. At the workshop, experts from public and private sectors at home and abroad will address the socio-economic impacts and implications of the emergence of new technologies that the Fourth Industrial Revolution will bring about. The workshop will be hosted in collaboration with the World Economic Forum’s Global Future Council (GFC) on Technology, Values and Policy. The World Economic Forum’s network of GFCs is the world’s foremost interdisciplinary knowledge network dedicated to promoting innovative thinking about the future. Four keynote speakers, including Professor Wendell Wallach of the Interdisciplinary Center for Bioethics at Yale University and Dean of the School of Public Policy and Management at Tsinghua University Lan Xue, will deliver speeches. Professor Wallach is the leader of an AI/Robotics Global Governance Project sponsored by the World Economic Forum and will make a speech entitled “Build the Global Infrastructure to Make Sure that AI and Robotics Will Be Beneficial.” Dean Xue, a member of the World Economic Forum’s GFC on Tech, Values, and Policy, is well known for his analysis of the social implications of the risks brought about by emerging technologies. He will speak on “Global Risk Governance of Disruptive 4IR Technologies.” More than thirty experts will participate in the workshop. Speakers include the KAIST Vice President for Planning and Budget Soohyun Kim, Dean of KAIST Institute San Yup Lee, Professor Jaeseung Jeong of the Department of Bio and Brain Engineering at KAIST, Dr. Sung Chul Kang of the KIST Healthcare Robotics Research Group, and Korea Evaluation Institute of Industrial Technology Program Director Kyong Hoon Kim. The CSPS of KAIST will continue to make collaborative research efforts with the GFC for developing new insights and perspectives on key global systems as well as study the impact and governance of key emerging technologies.
2017.03.16
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KAIST to Participate in the 2017 Davos Forum
(President Sung-Mo Kang and Distinguished Professor Sang Yup Lee) KAIST representatives will join high profile, multi-stakeholder dialogues with global leaders across the world to discuss higher education, science, and technological innovation. KAIST President Sung-Mo Kang and Distinguished Professor Sang Yup Lee of the Chemical and Biomolecular Engineering Department will participate in the World Economic Forum’s (WEF) Annual Meeting on January 17-20, 2017, in Davos-Klosters, Switzerland. To be held under the theme “Responsive and Responsible Leadership,” the Annual Meeting will offer global leaders from government, business, academia, and civil society a highly interactive platform to address some of the most pressing issues facing the world today, from climate change, economic inequality, to the Fourth Industrial Revolution and its impact on future employment. On January 18, President Kang will participate in the Global University Leaders Forum, a community of top 26 universities invited from around the world, and will discuss the relevance of higher education in the context of the Fourth Industrial Revolution. He will also share KAIST’s experiences in developing innovative initiatives to bring future-oriented and creative values into its educational and research programs. On January 19, at the Global Future Council on Production, President Kang will speak about new technologies taking place in traditional production and distribution systems as introduced by the emergence of rapidly evolving technological advancements, and present KAIST’s endeavors to transform those changes into opportunities. With an eminent group of scientists, including the Director of the US National Science Foundation France A. Córdova and the Editor-in-Chief Philip Campbell of Nature at the Global Science Outlook session, on January 20, President Kang will discuss key challenges for the global science agenda in the year ahead and examine the role of science in formulating public discussions and polices that will have great impact on society and the lives of people. Currently, Professor Lee is the founding Co-Chair of the WEF’s Global Future Council, an interdisciplinary knowledge network dedicated to promoting innovative thinking on the future. On January 20, he will share his insights at an independent session entitled “World Changing Technology: Biotech and Neurotech,” briefing the audience on the current state of research, development, and commercialization in these fields, as well as explaining how they will contribute to coping with the Fourth Industrial Revolution. Professor Lee said, “In recent years, we have seen the world become ever more complex, interconnected, and realigned as it is deeply affected by this unprecedented technological innovations, collectively driving the Fourth Industrial Revolution. One pillar of such innovation will take place in biotechnology and neuroscience, which will help us design solutions to many of global problems such as environment, pandemic diseases, aging, healthcare, and previously intractable illnesses.” President Kang added, “This year’s Davos meeting will focus on the need to foster leadership at the national, regional, and global level to respond collectively with credible actions to issues of major concern for the sustainable and equitable growth, social inclusion, and human development. KAIST has always been a crucial player in these collaborative efforts, and I am happy to share our insights at the upcoming event.”
2017.01.17
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Mystery of Biological Plastic Synthesis Machinery Unveiled
Plastics and other polymers are used every day. These polymers are mostly made from fossil resources by refining petrochemicals. On the other hand, many microorganisms naturally synthesize polyesters known as polyhydroxyalkanoates (PHAs) as distinct granules inside cells. PHAs are a family of microbial polyesters that have attracted much attention as biodegradable and biocompatible plastics and elastomers that can substitute petrochemical counterparts. There have been numerous papers and patents on gene cloning and metabolic engineering of PHA biosynthetic machineries, biochemical studies, and production of PHAs; simple Google search with “polyhydroxyalkanoates” yielded returns of 223,000 document pages. PHAs have always been considered amazing examples of biological polymer synthesis. It is astounding to see PHAs of 500 kDa to sometimes as high as 10,000 kDa can be synthesized in vivo by PHA synthase, the key polymerizing enzyme in PHA biosynthesis. They have attracted great interest in determining the crystal structure of PHA synthase over the last 30 years, but unfortunately without success. Thus, the characteristics and molecular mechanisms of PHA synthase were under a dark veil. In two papers published back-to-back in Biotechnology Journal online on November 30, 2016, a Korean research team led by Professor Kyung-Jin Kim at Kyungpook National University and Distinguished Professor Sang Yup Lee at the Korea Advanced Institute of Science and Technology (KAIST) described the crystal structure of PHA synthase from Ralstonia eutropha, the best studied bacterium for PHA production, and reported the structural basis for the detailed molecular mechanisms of PHA biosynthesis. The crystal structure has been deposited to Protein Data Bank in February 2016. After deciphering the crystal structure of the catalytic domain of PHA synthase, in addition to other structural studies on whole enzyme and related proteins, the research team also performed experiments to elucidate the mechanisms of the enzyme reaction, validating detailed structures, enzyme engineering, and also N-terminal domain studies among others. Through several biochemical studies based on crystal structure, the authors show that PHA synthase exists as a dimer and is divided into two distinct domains, the N-terminal domain (RePhaC1ND) and the C-terminal domain (RePhaC1CD). The RePhaC1CD catalyzes the polymerization reaction via a non-processive ping-pong mechanism using a Cys-His-Asp catalytic triad. The two catalytic sites of the RePhaC1CD dimer are positioned 33.4 Å apart, suggesting that the polymerization reaction occurs independently at each site. This study also presents the structure-based mechanisms for substrate specificities of various PHA synthases from different classes. Professor Sang Yup Lee, who has worked on this topic for more than 20 years, said, “The results and information presented in these two papers have long been awaited not only in the PHA community, but also metabolic engineering, bacteriology/microbiology, and in general biological sciences communities. The structural information on PHA synthase together with the recently deciphered reaction mechanisms will be valuable for understanding the detailed mechanisms of biosynthesizing this important energy/redox storage material, and also for the rational engineering of PHA synthases to produce designer bioplastics from various monomers more efficiently.” Indeed, these two papers published in Biotechnology Journal finally reveal the 30-year mystery of machinery of biological polyester synthesis, and will serve as the essential compass in creating designer and more efficient bioplastic machineries. References: Jieun Kim, Yeo-Jin Kim, So Young Choi, Sang Yup Lee and Kyung-Jin Kim. “Crystal structure of Ralstonia eutropha polyhydroxyalkanoate synthase C-terminal domain and reaction mechanisms” Biotechnology Journal DOI: 10.1002/biot.201600648 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600648/abstract Yeo-Jin Kim, So Young Choi, Jieun Kim, Kyeong Sik Jin, Sang Yup Lee and Kyung-Jin Kim. “Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme” Biotechnology Journal DOI: 10.1002/biot.201600649 http://onlinelibrary.wiley.com/doi/10.1002/biot.201600649/abstract
2016.12.02
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