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Breastfeeding Helps Prevent Mothers from Developing Diabetes after Childbirth
A team of South Korean researchers found that lactation can lower the incidence and reduce the risk of maternal postpartum diabetes. The researchers identified that lactation increases the mass and function of pancreatic beta cells through serotonin production. The team suggested that sustained improvements in pancreatic beta cells, which can last for years even after the cessation of lactation, improve mothers’ metabolic health in addition to providing health benefits for infants. Pregnancy imposes a substantial metabolic burden on women through weight gain and increased insulin resistance. Various other factors, including a history of gestational diabetes, maternal age, and obesity, further affect women’s risk of progressing to diabetes after delivery, and the risk of postpartum diabetes increases more in women who have had gestational diabetes and/or repeated deliveries. Diabetes-related complications include damage to blood vessels, which can lead to cardiovascular and cerebrovascular diseases such as heart attack and stroke, and problems with the nerves, eyes, kidneys, and many more. Since diabetes can pose a serious threat to mothers’ metabolic health, the management of maternal metabolic risk factors is important, especially in the peripartum period. Previous epidemiological studies have reported that lactation reduces the risk of postpartum diabetes, but the mechanisms underlying this benefit have remained elusive. The study, published in Science Translational Medicine on April 29, explains the biology underpinning this observation on the beneficial effects of lactation. Professor Hail Kim from the Graduate School of Medical Science and Engineering at KAIST led and jointly conducted the study in conjunction with researchers from the Seoul National University Bundang Hospital (SNUBH) and Chungnam National University (CNU) in Korea, and the University of California, San Francisco (UCSF) in the US. In their study, the team observed that the milk-secreting hormone ‘prolactin’ in lactating mothers not only promotes milk production, but also plays a major role in stimulating insulin-secreting pancreatic beta cells that regulate blood glucose in the body. The researchers also found that ‘serotonin’, known as a chemical that contributes to wellbeing and happiness, is produced in pancreatic beta cells during lactation. Serotonin in pancreatic beta cells act as an antioxidant and reduce oxidative stress, making mothers’ beta cells healthier. Serotonin also induces the proliferation of beta cells, thereby increasing the beta cell mass and helping maintain proper glucose levels. The research team conducted follow-up examinations on a total of 174 postpartum women, 85 lactated and 99 non-lactated, at two months postpartum and annually thereafter for at least three years. The results demonstrated that mothers who had undergone lactation improved pancreatic beta cell mass and function, and showed improved glucose homeostasis with approximately 20mg/dL lower glucose levels, thereby reducing the risk of postpartum diabetes in women. Surprisingly, this beneficial effect was maintained after the cessation of lactation, for more than three years after delivery. Professor Kim said, “We are happy to prove that lactation benefits female metabolic health by improving beta cell mass and function as well as glycemic control.” “Our future studies on the modulation of the molecular serotonergic pathway in accordance with the management of maternal metabolic risk factors may lead to new therapeutics to help prevent mothers from developing metabolic disorders,” he added. This work was supported by grants from the National Research Foundation (NRF) and the National Research Council of Science and Technology (NST) of Korea, the National Institutes of Health (NIH), the Larry L. Hillblom Foundation, and the Health Fellowship Foundation. Image credit: Professor Hail Kim, KAIST Image usage restrictions: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only. Publication: Moon, J. H et al. (2020) ‘Lactation improves pancreatic β cell mass and function through serotonin production.’ Science Translational Medicine, 12, eaay0455. Available online at https://doi.org/10.1126/scitranslmed.aay0455 Profile: Hail Kim, MD, PhD hailkim@kaist.edu Associate Professor Graduate School of Medical Science and Engineering (GSMSE) Korea Advanced Institute of Science and Technology (KAIST) Profile: Hak Chul Jang, MD, PhD janghak@snu.ac.kr Professor Division of Endocrinology and Metabolism Seoul National University Bundang Hospital (SNUBH) President Korean Diabetes Association Profile: Joon Ho Moon, MD, PhD moonjoonho@gmail.com Clinical Fellow Division of Endocrinology and Metabolism SNUBH Profile: Hyeongseok Kim, MD, PhD hskim85kor@gmail.com Assistant Professor Chungnam National University (CNU) Profile: Professor Michael S. German, MD Michael.German@ucsf.edu Professor Diabetes Center University of California, San Francisco (UCSF) (END)
2020.04.29
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Long Economic Depressions and Disparities Loom in the Wake of the COVID-19
"Global Cooperation for Managing Data Key to Mitigating the Impacts Around the World" <Full recorded video of the GSI-IF2020> The COVID-19 pandemic will lead to long economic depressions around the entire world. Experts predicted that the prevalent inequities among the countries, regions, and individuals will aggravate the economic crisis. However, crises always come with new opportunities and international cooperation and solidarity will help creating a new normal in the post-coronavirus era. In a very basic but urgent step, global cooperation for managing data is the key to respond to COVID-19 since medicine and healthcare are intertwined with data science, said experts during an online international forum hosted by the Global Strategy Institute at KAIST on April 22. KAIST launched its think-tank, the Global Strategy Institute (GSI), in February. The GSI aims to identify global issues proactively and help make breakthroughs well aligned with solid science-based policies. The inaugural forum of the GSI focused on how the COVID-19 pandemic would impact socio-economic, scientific, and political landscapes, under the theme “Global Cooperation in the Coronavirus Era.” In his opening remarks, KAIST President Sung-Chul Shin stressed that future global governance will be dominated by the power of science and technology. “If we can implement efficient policies together with troubleshooting technology for responding to future crises, we will emerge stronger than before,” he said. President Shin said ‘the Korean model’, which is being recognized as a shining example for dealing with the pandemic, is the result of collaborations combining the creativity of the private sector, the public sector’s strong infrastructure, and the full support of the citizens. He added, “Without the technological prowess coming from the competent R&D power of Korea, we could not achieve these impressive results.” “Creative collaboration among the private and public sectors, along with research universities from around the world, will help shore up global resilience against the epidemic. We should work together to build a world of growing prosperity,” President Shin said. Prime Minister Sye-Kyun Chung, who is in charge of the Central Disaster and Safety Countermeasures Headquarters in Korea, stressed global solidarity in his welcoming remarks, saying that “We need to share information and rely on the strength of our connections, rather than retreating into nationalistic isolation.” Peter Lee, Vice President of the Microsoft Healthcare, pointed out in his welcoming remarks three critical sectors for global cooperation: medicine and healthcare, public health and prevention, and life and the economy. He emphasized the rule of thumb for managing data, saying that data in these fields should be open, standardized, and shared among countries to combat this global pandemic. During a keynote session, Director General of the International Vaccine Institute (IVI) Jerome Kim described the challenges that go along with developing a vaccine. Dr. Kim said that only 7% of vaccine candidates go through the clinical trial stages, and it will take five to 10 years to completely prove a new vaccine’s safety after completing three stages of clinical tests. “It’s very challenging to develop the vaccine for COVID-19 within 12 to 15 months,” said Dr. Kim. He added that 78 out of 115 candidates are currently undergoing clinical trials around the world. There are five groups, including Moderna, Inovio, Jenner Institute, CanSino, and the Beijing Institute of Biological Products, who are doing clinical trials in phases 1 and 2. “Given the fact that COVID-19 is a totally new type of virus, various stakeholders’ participation, such as the National Immunization Technical Advisory Groups, the WHO, and UNICEF, is needed to work together to benefit the entire world,” he pointed out. Professor Edward Yoonjae Choi from the Graduate School of AI at KAIST shared how AI and data sciences are being utilized to interpret the major trends of the epidemic. His group mainly focuses on deep learning to model electronic health records (EHR) for disease predictions. Professor Choi said AI and machine learning would be crucial solutions and collaborative research projects will surely accelerate how quickly we can overcome the pandemic. In addition, Dr. Kijung Shin’s group is interpreting the SIR (Susceptible, Infected, and Recovered) model in Korea to predict the number of infections and when people were infected. However, researchers noticed that they could not see the typical modeling in Korea for predicting the number of infections since the model disregarded the new variable of humans’ efforts to stop the spread the virus. According to research by Professor Steven Whang’s group on social distancing and face mask distribution among vulnerable age groups, people in their 20s, 60s, and 70s followed the social distancing guidelines the most strictly. The research team analyzed the data provided by SK Telecom in the Gangnam district of Seoul. The data provided on people in their 70s, a group that accounted for half of all fatalities, showed that masks were generally well distributed nationwide. Dr. Alexandros Papaspyrids, Tertiary Education Industry Director of the Asia region of Microsoft, said that despite all the disadvantages and problems related to remote education, we shouldn’t expect to return to the days before the COVID-19 any time soon. “We should accept the new normal and explore new opportunities in the new educational environment,” he said. Hongtaek Yong, Deputy Minister at the Office of R&D Policy at the Ministry of Science and ICT presented the Korean government’s disease prevention and response policy and how they tried to mitigate the economic and social impact. He stressed the government’s fast testing, tracing, and openness for successfully flattening the curve, adding that the government used an ICT-based approach in all aspects of their response. From early this year when the first patient was reported, the government aggressively encouraged the biotech industry to develop diagnostic kits and novel therapeutic medications. As a result, five companies were able to produce genetic diagnostic reagents through the emergency approval. More notably, four of them are conducting massive R&D projects sponsored by the government and this is the result of the government’s continuous investment in R&D. Korea is the leader in R&D investment among the OECD countries. According to Yong, the government’s big data project that was launched in 2017 continuously traces the trends of epidemics in Korea. The epidemiological studies based on the paths taken by suspected patients using credit card transaction made the difference in predicting the spread of the coronavirus and implementing countermeasures. The data has been provided to the Korea’s Center for Disease Control (CDC). “In addition to the epidemics, we have so many other pending issues arising from digital and social equities, un-contact services, and job security. We are very open to collaborate and cooperate with other countries to deal with this global crisis,” Yong said. During the subsequent panel discussions, David Dollar, a senior fellow at the Brookings Institution, said, “The global economy in the coronavirus era will not have a rapid V-shaped recovery, but rather will fall into a long depression for at least two years.” He pointed out that if countries practice protectionism like they did during the Great Depression, the recession will be even worse. Hence, he urged the international community, especially developed nations, to avoid protectionism, consider the economic difficulties of developing countries, and provide them with financial support. Co-Director of the Center for Universal Education at the Brookings Institution Rebecca Winthrop raised concerns over the recent shift to online teaching and learning, claiming that insufficient infrastructures in low-income families in developing nations are already causing added educational disparities and provoking the inequity issue around the world. “The ways to provide quality education equally through faster and more effective means should be studied,” she said. Professor Joungho Kim, the director of the KAIST GSI and the forum’s organizer, concluded the event by saying that this forum will be a valuable resource for everyone who is providing assistance to those in need, both during and after the COVID-19 pandemic. (END)
2020.04.22
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14-Day Drawing Challenge Helps Maintain a Sense of Connection Amid Prolonged Social Distancing
- “You need space, but you also need connections.” - Schools and workplaces have closed and people are staying at home around the globe. Governments across the world have urged their people to keep a distance from others as a measure to slow the spread of the pandemic. With the Korean government’s decision to extend the intensive social distancing campaign until at least April 19, people in Korea are advised to avoid nonessential trips, public facilities, and social gatherings for another two weeks or so. This unprecedented prolonged social distancing drive leads people to feel fatigue and frustration. Such emotional stress is worse for those who live alone in a foreign country. The International Scholar and Student Services (ISSS) Team at KAIST has been working around the clock to build a dedicated COVID-19 Mental Health Support Service to support the university’s international community on campus and abroad and help get them connected online. As the COVID-19 situation lingers, there has been a growing demand for mental health support from many KAIST international members including 299 students who have been staying in Korea on their own and away from their families, as well as from those who could not return to campus from their overseas homes. In response to this, the KAIST ISSS Team has been offering some special online events and programs that can help the KAIST international community stay feeling connected whereever they are, while still keeping a safe distance from each other. For instance, the team is running an art-therapy program called ‘The 14-day Drawing Challenge’ March 30 through April 12. This program is online and individual-based, so it does not require any physical contact between participants. Each participant is asked to draw a picture at home using the daily topics previously set by the ISSS Team over 14 days. The topics include (Day 1) self-portrait, (Day 2) spring flowers, (Day 3) if you could become anything…, (Day 4) funniest memory you have, (Day 5) animals at KAIST, (Day 6) something you love, (Day 7) country or city you want to visit, (Day 8) what’s for dinner? (Day 9) person you miss, (Day 10) your favorite place at KAIST, (Day 11) your feeling today, (Day 12) things in your favorite color, (Day 13) song lyrics, and (Day 14) your future self in 10 years. Once all 14 pieces have been completed, submissions can be made online by sending an e-mail to the ISSS Team after scanning or taking a photo of each drawing. Selected submissions will be awarded small prizes for participation and shared through the university’s official website and SNS channels. “All the participants need is paper, coloring tools, and their creativity and imagination. They don’t have to be a great artist to join this challenge. There is no right or wrong or good or bad. They just need to have fun drawing every day for two weeks, ease their coronavirus anxiety, and remain emotionally stable just like they did back in the normal days,” said Su-yeon Ahn, the manager of the KAIST ISSS Team. She added, “In times like these, you need space, but you also need connections. Our team wants our international students, professors, and researchers to build strong connections with each other, even online.” Katherine Michelle Pena Santana, an M.S. candidate from the Department of Industrial and Systems Engineering who is taking part in ‘The 14-day Drawing Challenge,’ looked back and said, “Lately with the new coronavirus spreading around Korea and the entire world, I was feeling very anxious. I didn't get out of my room and lived by just looking at the same walls and creating some kind of a psychological burden on myself.” Santana added that these kinds of activities could give many foreign members of KAIST an opportunity to not only relieve fear and stress, but also share each other’s experiences dealing with this pandemic. She explained that this is why she decided to participate in this challenge. An undergraduate student from the Department of Physics, Ada Carpenter, appreciated the KAIST ISSS Team’s efforts to provide a variety of special online mental health support services to help the university’s international community socialize, while strictly following the government’s guidelines for social distancing. She expressed excitement about participating and said, “I’m so looking forward to the challenge of things that I wouldn’t normally draw.” < Short Self-interview Video Clip Filmed by Ada Carpenter > The COVID-19 Mental Health Support Service by the KAIST ISSS Team will be continually updated with new information and enhanced with other tools and support over the coming weeks and months. Some of the upcoming events and programs include ‘The Online Guitar Lessons’, ‘The Growing Houseplants Challenge’, and ‘The Any Song Challenge*’. * The song titled “Any Song” by Korean rapper Zico has been gaining attention on social media thanks to many celebrities taking on the ‘Any Song Challenge’, performing a short dance to the chorus of the song and sharing it on social media. (END)
2020.04.08
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COVID-19 Update: Reaching Out to Help Local Schools’ Online Classes
After the Ministry of Education decided that all schools would conduct online classes from April 9, schools began to ramp up online education tools and systems. On March 30, the Ministry announced a three-phased opening for the schools, putting online classes for third-year middle and high school students first. The online classes will expand to first and second-year middle and high schoolers and the upper grades of elementary schools on April 16, followed by first to third graders of elementary schools on April 20. Although some schools have already introduced online teaching and learning into the curriculum, most schools are still unprepared, raising concerns over possible educational disparities caused by insufficient infrastructures and a lack of training for teachers. To counter these issues, KAIST rolled up its sleeves to help teachers from 38 local middle and high schools in the Yuseong District of Daejeon better prepare for their interactive online classes by providing a special training course from April 7 through 29. Following the course, approximately 40 undergraduate and graduate students will be assigned to schools to help them set up and better utilize the online educational program. On April 3, Professor Youngsun Kwon, the Dean of KAIST Academy and the Director of the Center for Excellence in Learning and Teaching, gave a two-hour online interactive tutorial session on the utilization of the real-time video conferencing platform ‘Zoom’ for online classes. He shared best practices for checking attendance, running classes, and giving and marking quizzes and assignments. A total of 102 local middle and high school teachers attended this session. “We feel very fortunate to reach out to teachers who are so passionate about learning online education methodology. We were pleasantly surprised to see this many educators show up for the tutorial session,” said Dean Kwon. He also appreciated KAIST students’ strong interests and support in the community outreach project in response to COVID-19 during these challenging times when social distancing is so critical. He said more than 150 student volunteers signed up for this project 10 hours after his office posted the opening for volunteers on the KAIST intranet. “We will help front-line school teachers, strictly following the government’s guidelines for social distancing,” he added. The students’ online class support group will provide additional help to schools that are inexperienced users of Zoom. The students will be those who are very familiar with online lectures using Zoom, and are fully acquainted with how to operate them. One or two of the students will be assigned to each school that requests support, and will directly help solve complications that stem from preparing and running the classes through online measures for safety reasons. The expenses for the support group’s activities will be fully covered by KAIST, and the period of support may be extended upon request. KAIST has been offering approximately 1,200 courses remotely since the spring semester opened on March 16 and will do so until the COVID-19 situation stabilizes. Along with the provision of pre-recorded one-way lecture contents, real-time two-way lessons are being delivered through various video conferencing platforms including Zoom, YouTube Live, and Microsoft Teams. There were both minor and major technical issues at the beginning of the semester, caused by the instability of servers and system overloads as well as from users being inexperienced with the tools and systems. However, the class procedures have gradually stabilized and are now running better. KAIST President Sung-Chul Shin said, “As the COVID-19 situation lingers, this is a more difficult time than ever, where all educational establishments and educators must quickly learn and apply new methods of education, often in insufficient preparation conditions.” He added, “KAIST will provide support for secondary schools in the region to quickly resolve the inconveniences caused by new users of online classes so that they may provide high-quality education.” (END)
2020.04.06
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COVID-19 Map Shows How the Global Pandemic Moves
- A School of Computing team facilitated the data from COVID-19 to show the global spread of the virus. - The COVID-19 map made by KAIST data scientists shows where and how the virus is spreading from China, reportedly the epicenter of the disease. Professor Meeyoung Cha from the School of Computing and her group facilitated data based on the number of confirmed cases from January 22 to March 22 to analyze the trends of this global epidemic. The statistics include the number of confirmed cases, recoveries, and deaths across major continents based on the number of confirmed case data during that period. The moving dot on the map strikingly shows how the confirmed cases are moving across the globe. According to their statistics, the centroid of the disease starts from near Wuhan in China and moved to Korea, then through the European region via Italy and Iran. The data is collected by a graduate student from the School of Computing, Geng Sun, who started the process during the time he was quarantined since coming back from his home in China. An undergraduate colleague of Geng's, Gabriel Camilo Lima who made the map, is now working remotely from his home in Brazil since all undergraduate students were required to move out of the dormitory last week. The university closed all undergraduate housing and advised the undergraduate students to go back home in a preventive measure to stop the virus from spreading across the campus. Gabriel said he calculated the centroid of all confirmed cases up to a given day. He explained, “I weighed each coordinate by the number of cases in that region and country and calculated an approximate center of gravity.” “The Earth is round, so the shortest path from Asia to Europe is often through Russia. In early March, the center of gravity of new cases was moving from Asia to Europe. Therefore, the centroid is moving to the west and goes through Russia, even though Russia has not reported many cases,” he added. Professor Cha, who is also responsible for the Data Science Group at the Institute for Basic Science (IBS) as the Chief Investigator, said their group will continue to update the map using public data at https://ds.ibs.re.kr/index.php/covid-19/. (END)
2020.03.27
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COVID-19 Update: Students and Professors Adjust to 1,200 Online Classes
- Approximately 1,200 online classes are being offered during the cyber semester. - COVID-19 is transforming the way KAISTians live. Many restrictions imposed to contain the spread of the virus have us adjusting to a new environment swiftly. A cyber MOU signing ceremony with a foreign partner university took place on March 25, as did a cyber Board of Trustees Meeting on March 26. KAIST’s Main Campus is normally one of the most iconic picnic destinations for the citizens of Daejeon, but this is not the case this spring, as the campus has been temporarily closed to protect our own community as well as our neighboring communities. KAIST has been offering approximately 1,200 courses remotely since this semester opened on March 16 and will do so until further notice. Students and faculty members are experiencing the newly emerging norms of remote education in this time of social distancing. This unexpected disruption might advance the new digital pedagogy at KAIST, which was already ahead of the curve with its online learning and teaching infrastructure. Professor Youngsun Kwon, the Dean of KAIST Academy and the Director of the Center for Excellence in Learning and Teaching, said, “We had already initiated the KAIST Learning Management System (KLMS) in 2011 for introducing flipped learning, a student-centric creative-learning pedagogy. Since then, about nine percent of all our classes have been run using this methodology. Students pre-study the online streaming lecture materials that professors have uploaded in advance outside the classroom, and in-class activities are mainly group discussions and problem-solving activities.” According to Dean Kwon, the university was planning to further introduce real-time online education from this spring semester and were in the process of setting up the system started from last year. “Our plan was to connect the real-time video conferencing service Zoom to our existing remote educational platform KLMS. However, things related to COVID-19 all happened so rapidly that we didn’t yet have a full-fledged connection,” said Dean Kwon. Professors had to choose either to conduct their lectures remotely in the form of a pre-made one-way lesson or a real-time two-way lesson. They could also modify them using both platforms. Professor Youngchul Kim from the Department of Civil and Environmental Engineering said, “I had to also make some changes in my class activities and assignments. I removed a group design project and some tutorial workshops that were meant to provide students with hands-on experience using design tools such a 3D printer and a laser cutting system. Ironically, I found that students seem to focus on online lectures more intensely than I expected. I feel like students give me their thoughts and respond much quicker as well.” Unfortunately, the online learning and teaching infrastructure and resources that had been put in place could not handle the overwhelming volume of classes being uploaded over very short period of time. To handle the new demand, IT technicians are setting up the technical environment with stable servers to improve network traffic. For professors, teaching assistants, and students to teach and learn better in an online space, department offices have been lending spare equipment such as laptops, tablets, headsets, and webcams to those who do not have their own, based on availability. Academic support staff have also been pitching in by developing the best guidelines for online training. “Even in these uncharted waters, all of the members of KAIST are doing their best to keep the ship steadily sailing in the right direction. I am very grateful for everyone’s efforts to make things work,” said Dean Kwon. About 60% of the courses currently offered online are being uploaded using the non-real-time KLMS, and the remaining 40% are run in real time via Zoom. Each class runs for 50 minutes per academic credit, and comprises at least 25 minutes of lecture, a Q&A session, and a group discussion. Students enrolled in the 481 courses that include experiments are asked to conduct their experiments individually after watching a 50-minute online lecture. Experimental, practical, and physical courses that are impossible to provide online have been cancelled or postponed until the next semester or summer/winter breaks. “I find the online lessons quite convenient for the courses that I am taking this semester, especially the non-real-time ones, because I can watch the lecture videos over and over again even after the class has finished to understand the contents better,” said Jaymee Palma, an undergraduate student from the Department of Chemistry. Ada Carpenter, an undergraduate student from the Department of Physics, added, “Students who normally feel uncomfortable speaking in class raise their questions on an online Q&A board more easily. Besides, I saw many other students asking questions and leading a discussion verbally as well. I think, when students join a synchronous Zoom classroom, they are more engaged than when just attending a regular lecture in a conventional classroom. It’s like everyone can sit in the front row of the class.” Still, there are reportedly pedagogical, logistical, and technological challenges to these extraordinary educational measures. Some students express concerns about keeping up with professors and other students if they don’t have sufficient technological knowledge and skills. Some also cite the disadvantage of online classes having much less interaction and engagement among students and between professors and students than offline ones. “Fortunately, I think my professors are all excellent, so I can immerse myself well during all my cyber classes,” said Sang-Hyeon Lee, a graduate student from the School of Computing. (END)
2020.03.26
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‘OSK Rising Stars 30’ Recognizes Four KAISTians
Four KAISTians were selected as star researchers to brighten the future of optics in commemoration of the 30th anniversary of the Optical Society of Korea (OSK). As ‘OSK Rising Stars 30’, the OSK named 27 domestic researchers under the age of 40 who have made significant contributions and will continue contributing to the development of Korea’s optics academia and industry. Professor YongKeun Park from the Department of Physics was selected in recognition of his contributions to the field of biomedical optics. Professor Park focuses on developing novel optical methods for understanding, diagnosing, and treating human diseases, based on light scattering, light manipulation, and interferometry. As a member of numerous international optics societies including the OSA and the SPIE and a co-founder of two start-up companies, Professor Park continues to broaden his boundaries as a leading opticist and entrepreneur. Professor Jonghwa Shin from the Department of Materials Science and Engineering was recognized for blazing a trail in the field of broadband metamaterials. Professor Shin’s research on the broadband enhancement of the electric permittivity and refractive index of metamaterials has great potential in both academia and industry. Professor Hongki Yoo from the Department of Mechanical Engineering is expected to create a significant ripple effect in the diagnosis of cardiovascular disorders through the development of new optical imaging techniques and applications. Finally, Dr. Sejeong Kim, a KAIST graduate and a Chancellor’s postdoctoral research fellow at the University of Technology Sydney (UTS), was acknowledged for her optical device research utilizing two-dimensional materials. Dr. Kim’s research at UTS now focuses on the introduction of micro/nano cavities for new materials. (END)
2020.03.16
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COVID-19 Update: All Undergrad Housing Closed
KAIST stepped up preventive measures against the outbreak of COVID-19 by closing all housing complexes for undergraduate students. Provost Kwang-Hyung Lee, in an email to KAIST community members on March 12, advised all undergraduate students who had already moved in to the dormitories to move out by March 23. The university opened the spring semester on March 16, two weeks later than originally scheduled, due to the outbreak. All in-person classes have been shifted to online classes and this will continue until further notice. “The dormitory would likely become the source of a COVID-19 cluster on the campus. Given the gravity of the current situation, we can’t help but make this unprecedented measure. It is fully for the best interests for our students’ health and safety. It saddens me to say that students are required to go back to their homes,” said Provost Lee. Dormitory fees will be refunded, and transportation and storage services will be provided for students who return back home. It has not yet been decided when they can return to the campus. There are four exceptional cases for this special measure: 1. when a student does not have legal residency in Korea, 2. if a student’s legal residence is located in a severely affected region such as Daegu, Chongdo, and Kyongsan, 3. if students in their final semester before the graduation need to take a research class that is not available online, 4. if students have a very special reason that does not allow them to stay at home. Such students are required to meet the Associate Vice President of Student Life for approval of the exceptional stay. Meanwhile, the first day of the online semester on March 16 saw an overwhelming amount of traffic on the remote educational platform, the KAIST learning management system (KLMS), and the real-time platform, Zoom. The two systems were both overloaded. The Dean of the KAIST Academy sent an email to the community, explaining the technical glitch causing the overload. He said his office had fixed the problem, allowing resumed access to the system from inside and outside the campus. Considered the nature of classes that are difficult or impossible to provide online, the university decided to cancel the some of physical training classes such as golf, dance sports, badminton, swimming, and tennis this semester. Social distancing is another issue the university is enhancing throughout the campus. The university announced new lunch break shifts to disperse the dining hall crowds; the first shift is from 11:30 to 12:30 and the second shift is from 12:30 to 13:30, effective from March 17. The COVID-19 response bulletin also instructed KAIST community members to sit in a row, not face to face, when eating together with colleagues, and asked them to refrain from talking while eating. In addition, a total of 29 virus and fine duster filtering machines have been installed across the campus dining facilities. The bulletin posted on March 13 restressed the importance of wearing a face mask in compact areas such as elevators and refrain the non-essential business or personal travel. Parents who need to take care of their children due to the closure of schools and day care centers are advised to work from home. (END)
2020.03.16
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COVID-19 Update: All Classes to Go Online after Semester Opens
All classes of undergraduate and graduate courses will go online from March 16 in a protective measure for the KAIST community to slow the spread of COVID-19. No decision has yet been made for how long the online classes will last. The spring semester will start two weeks later than scheduled due to the outbreak of the COVID-19. For online classes, professors are uploading their taped class video clips onto the KAIST Learning Management System (KLMS). These classes will be conducted in both real time and on demand. The video conferencing solution Zoom will be employed for real-time online classes, and professors and students will interact using the bulletin board function for on-demand classes. The university is scaling up its institutional response to protect the KAIST community against the outbreak of the disease following the cancellation and postponing of major academic events including the commencement and matriculation ceremonies scheduled in February and March. The new protective measures include all sports complexes and facilities temporarily closing from February 24. All building entrance gates are only accessible with those carrying a KAIST ID card. A total of nine fever monitors have been installed in the university headquarter building, main library, dining halls, the day care center at Daejeon campus, and at the Seoul campus. The Emergency Response Team is posting a daily bulletin and response manual on the KAIST portal system with updates on the number of confirmed cases in Daejeon and other regions including Seoul as well as reminder notices to help contain the spread. Provost Kwang-Hyung Lee advised KAIST community members to refrain from traveling to the gravely affected region and foreign countries in an email sent on March 11. Anyone who has a travel history in those regions should report it to the Emergency Response Team and self-quarantine for two weeks at home or in a designated dorm complex. KAIST surveyed all community members’ travel histories last month and instructed those who had traveled to Daegu and foreign countries or had contact with a confirmed patient to go into self-isolation or work from home while conducting intensive self-monitoring. They have been asked to report their temperature to the Emergency Response Team twice a day. The response manual recommends canceling or postponing meetings and events at the campus. “If necessary, we ask that you make a conference call instead,” said the Emergency Response Team. Meanwhile, the Academic Affairs Office decided to employ a flexible academic schedule in consideration of students’ circumstances during this extraordinary outbreak situation. “We still need to run 16 weeks of classes for the semester but we are being flexible in how the classes can be run. It will wholly depend on the professor and students’ discussions based on their situation. We won’t apply a unilateral mid-term and final exam week during this special time,” said the bulletin from the Academic Affairs Office. (END)
2020.03.11
View 5339
“A drop of water shall be returned with a rushing river.”
- Chinese KAISTians Donate Supplies to Fight COVID-19 in Daegu - The Chinese community at KAIST donated 2.49 million won worth of personal protective equipment on March 4 to support on-site medical personnel in the city of Daegu. South Korea has been witnessing a significant surge in novel COVID-19 transmissions, and Daegu and nearby North Gyeongsang Province are the most affected regions. As the COVID-19 situation grows more serious globally day by day, a Chinese master’s student from the KAIST Department of Civil and Environmental Engineering, Yuewen Jia, suggested a fundraising campaign on the KAIST Chinese Community’s WeChat messenger chat room, and her idea was enthusiastically supported by many peer-members. The KAIST Chinese Community is comprised of 105 undergraduates, graduates, post-doctoral fellows, researchers, and professors. With Jia’s post-doc colleague Pei Li volunteering to manage the fundraising process, a total of 2.49 million won was collected in 12 days between January 27 and February 7. The donors, including Qin Xu, a PhD candidate in the School of Electrical Engineering, reportedly asked for their donations to be used to support on-site medical personnel affected by the outbreak. They believed that medical supplies are the most essential in times like these. The group purchased personal protective equipment online and waited for more than 20 days until the items were finally delivered to them. The goods include 1,280 protective caps, 57 protective suits, 15 protective glasses, and two protective face shields. Given the surging spread of the COVID-19 disease in Korea, where the confirmed cases have increased multi-fold since mid-February, the KAIST Chinese Community decided that their items should be used immediately in Korea, instead of being sent back to their home country as they had planned. Guoyuan An, a student representative of the community studying for his master’s degree in the School of Computing, said, “Earlier, some members of the KAIST Chinese Community who had visited China were self-quarantined for two weeks in a special facility designated by KAIST as a precautionary measure. Thanks to the outstanding care we received from offices at KAIST including the COVID-19 Task Force Team, the International Office, the Student Offices, and the Clinic, those who were quarantined could return to campus safe and healthy.” He continued, “KAIST and the Koreans as a whole spared no effort in helping China and Chinese people living in Korea fight the COVID-19 outbreak in its early days, and all of the members of the KAIST Chinese Community felt deeply grateful for all the attention and aid. This has been a definitive reason for us to change the donate recipient from China to Korea.” “As an old Chinese saying goes, ‘A drop of water shall be returned with a rushing river.’ This proverb means that even if you receive a little help from others, you should return the favor with all you can when others are in need. We decided to make a donation ourselves in hopes that our small contribution could help on-site medical personnel work for the health and wellbeing of Koreans who are affected in that area.” he explained. The donated items were delivered to the Division of Disaster Preparedness and Emergency Management at the Daegu Metropolitan Government Office, with help from the on-campus medical center KAIST Clinic Pappalardo Center and the KAIST International Scholar and Student Services (ISSS) Team. Dr. Yun-Jung Lee, the executive director of the KAIST Clinic Pappalardo Center, expressed “a huge thank you to the KAIST Chinese Community for pitching in to help battle this national and global crisis.” She added, “Their donations have been passed to those in desperate need, and their warm-hearted act of kindness will go a long way.” (END)
2020.03.05
View 6775
New Catalyst Recycles Greenhouse Gases into Fuel and Hydrogen Gas
< Professor Cafer T. Yavuz (left), PhD Candidate Youngdong Song (center), and Researcher Sreerangappa Ramesh (right) > Scientists have taken a major step toward a circular carbon economy by developing a long-lasting, economical catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas, and other chemicals. The results could be revolutionary in the effort to reverse global warming, according to the researchers. The study was published on February 14 in Science. “We set out to develop an effective catalyst that can convert large amounts of the greenhouse gases carbon dioxide and methane without failure,” said Cafer T. Yavuz, paper author and associate professor of chemical and biomolecular engineering and of chemistry at KAIST. The catalyst, made from inexpensive and abundant nickel, magnesium, and molybdenum, initiates and speeds up the rate of reaction that converts carbon dioxide and methane into hydrogen gas. It can work efficiently for more than a month. This conversion is called ‘dry reforming’, where harmful gases, such as carbon dioxide, are processed to produce more useful chemicals that could be refined for use in fuel, plastics, or even pharmaceuticals. It is an effective process, but it previously required rare and expensive metals such as platinum and rhodium to induce a brief and inefficient chemical reaction. Other researchers had previously proposed nickel as a more economical solution, but carbon byproducts would build up and the surface nanoparticles would bind together on the cheaper metal, fundamentally changing the composition and geometry of the catalyst and rendering it useless. “The difficulty arises from the lack of control on scores of active sites over the bulky catalysts surfaces because any refinement procedures attempted also change the nature of the catalyst itself,” Yavuz said. The researchers produced nickel-molybdenum nanoparticles under a reductive environment in the presence of a single crystalline magnesium oxide. As the ingredients were heated under reactive gas, the nanoparticles moved on the pristine crystal surface seeking anchoring points. The resulting activated catalyst sealed its own high-energy active sites and permanently fixed the location of the nanoparticles — meaning that the nickel-based catalyst will not have a carbon build up, nor will the surface particles bind to one another. “It took us almost a year to understand the underlying mechanism,” said first author Youngdong Song, a graduate student in the Department of Chemical and Biomolecular Engineering at KAIST. “Once we studied all the chemical events in detail, we were shocked.” The researchers dubbed the catalyst Nanocatalysts on Single Crystal Edges (NOSCE). The magnesium-oxide nanopowder comes from a finely structured form of magnesium oxide, where the molecules bind continuously to the edge. There are no breaks or defects in the surface, allowing for uniform and predictable reactions. “Our study solves a number of challenges the catalyst community faces,” Yavuz said. “We believe the NOSCE mechanism will improve other inefficient catalytic reactions and provide even further savings of greenhouse gas emissions.” This work was supported, in part, by the Saudi-Aramco-KAIST CO2 Management Center and the National Research Foundation of Korea. Other contributors include Ercan Ozdemir, Sreerangappa Ramesh, Aldiar Adishev, and Saravanan Subramanian, all of whom are affiliated with the Graduate School of Energy, Environment, Water and Sustainability at KAIST; Aadesh Harale, Mohammed Albuali, Bandar Abdullah Fadhel, and Aqil Jamal, all of whom are with the Research and Development Center in Saudi Arabia; and Dohyun Moon and Sun Hee Choi, both of whom are with the Pohang Accelerator Laboratory in Korea. Ozdemir is also affiliated with the Institute of Nanotechnology at the Gebze Technical University in Turkey; Fadhel and Jamal are also affiliated with the Saudi-Armco-KAIST CO2 Management Center in Korea. <Newly developed catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas and other chemicals.> Publication: Song et al. (2020) Dry reforming of methane by stable Ni–Mo nanocatalysts on single-crystalline MgO. Science, Vol. 367, Issue 6479, pp. 777-781. Available online at http://dx.doi.org/10.1126/science.aav2412 Profile: Prof. Cafer T. Yavuz, MA, PhD yavuz@kaist.ac.kr http://yavuz.kaist.ac.kr/ Associate Professor Oxide and Organic Nanomaterials for the Environment (ONE) Laboratory Graduate School of Energy, Environment, Water and Sustainability (EEWS) Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea Profile: Youngdong Song ydsong88@kaist.ac.kr Ph.D. Candidate Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea (END)
2020.02.17
View 12540
What Fuels a “Domino Effect” in Cancer Drug Resistance?
KAIST researchers have identified mechanisms that relay prior acquired resistance to the first-line chemotherapy to the second-line targeted therapy, fueling a “domino effect” in cancer drug resistance. Their study featured in the February 7 edition of Science Advances suggests a new strategy for improving the second-line setting of cancer treatment for patients who showed resistance to anti-cancer drugs. Resistance to cancer drugs is often managed in the clinic by chemotherapy and targeted therapy. Unlike chemotherapy that works by repressing fast-proliferating cells, targeted therapy blocks a single oncogenic pathway to halt tumor growth. In many cases, targeted therapy is engaged as a maintenance therapy or employed in the second-line after front-line chemotherapy. A team of researchers led by Professor Yoosik Kim from the Department of Chemical and Biomolecular Engineering and the KAIST Institute for Health Science and Technology (KIHST) has discovered an unexpected resistance signature that occurs between chemotherapy and targeted therapy. The team further identified a set of integrated mechanisms that promotes this kind of sequential therapy resistance. “There have been multiple clinical accounts reflecting that targeted therapies tend to be least successful in patients who have exhausted all standard treatments,” said the first author of the paper Mark Borris D. Aldonza. He continued, “These accounts ignited our hypothesis that failed responses to some chemotherapies might speed up the evolution of resistance to other drugs, particularly those with specific targets.” Aldonza and his colleagues extracted large amounts of drug-resistance information from the open-source database the Genomics of Drug Sensitivity in Cancer (GDSC), which contains thousands of drug response data entries from various human cancer cell lines. Their big data analysis revealed that cancer cell lines resistant to chemotherapies classified as anti-mitotic drugs (AMDs), toxins that inhibit overacting cell division, are also resistant to a class of targeted therapies called epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). In all of the cancer types analyzed, more than 84 percent of those resistant to AMDs, representatively ‘paclitaxel’, were also resistant to at least nine EGFR-TKIs. In lung, pancreatic, and breast cancers where paclitaxel is often used as a first-line, standard-of-care regimen, greater than 92 percent showed resistance to EGFR-TKIs. Professor Kim said, “It is surprising to see that such collateral resistance can occur specifically between two chemically different classes of drugs.” To figure out how failed responses to paclitaxel leads to resistance to EGFR-TKIs, the team validated co-resistance signatures that they found in the database by generating and analyzing a subset of slow-doubling, paclitaxel-resistant cancer models called ‘persisters’. The results demonstrated that paclitaxel-resistant cancers remodel their stress response by first becoming more stem cell-like, evolving the ability to self-renew to adapt to more stressful conditions like drug exposures. More surprisingly, when the researchers characterized the metabolic state of the cells, EGFR-TKI persisters derived from paclitaxel-resistant cancer cells showed high dependencies to energy-producing processes such as glycolysis and glutaminolysis. “We found that, without an energy stimulus like glucose, these cells transform to becoming more senescent, a characteristic of cells that have arrested cell division. However, this senescence is controlled by stem cell factors, which the paclitaxel-resistant cancers use to escape from this arrested state given a favorable condition to re-grow,” said Aldonza. Professor Kim explained, “Before this research, there was no reason to expect that acquiring the cancer stem cell phenotype that dramatically leads to a cascade of changes in cellular states affecting metabolism and cell death is linked with drug-specific sequential resistance between two classes of therapies.” He added, “The expansion of our work to other working models of drug resistance in a much more clinically-relevant setting, perhaps in clinical trials, will take on increasing importance, as sequential treatment strategies will continue to be adapted to various forms of anti-cancer therapy regimens.” This study was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF-2016R1C1B2009886), and the KAIST Future Systems Healthcare Project (KAISTHEALTHCARE42) funded by the Korean Ministry of Science and ICT (MSIT). Undergraduate student Aldonza participated in this research project and presented the findings as the lead author as part of the Undergraduate Research Participation (URP) Program at KAIST. < Figure 1. Schematic overview of the study. > < Figure 2. Big data analysis revealing co-resistance signatures between classes of anti-cancer drugs. > Publication: Aldonza et al. (2020) Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Science Advances, Vol. 6, No. 6, eaav7416. Available online at http://dx.doi.org/10.1126/sciadv.aav7416 Profile: Prof. Yoosik Kim, MA, PhD ysyoosik@kaist.ac.kr https://qcbio.kaist.ac.kr/ Assistant Professor Bio Network Analysis Laboratory Department of Chemical and Biomolecular Engineering Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea Profile: Mark Borris D. Aldonza borris@kaist.ac.kr Undergraduate Student Department of Biological Sciences Korea Advanced Institute of Science and Technology (KAIST) http://kaist.ac.kr Daejeon, Republic of Korea (END)
2020.02.10
View 8728
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