Engineering
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Professor Jong Chul Ye Appointed as Distinguished Lecturer of IEEE EMBS
Professor Jong Chul Ye from the Department of Bio and Brain Engineering was appointed as a distinguished lecturer by the International Association of Electrical and Electronic Engineers (IEEE) Engineering in Medicine and Biology Society (EMBS). Professor Ye was invited to deliver a lecture on his leading research on artificial intelligence (AI) technology in medical video restoration. He will serve a term of two years beginning in 2020.
IEEE EMBS's distinguished lecturer program is designed to educate researchers around the world on the latest trends and technology in biomedical engineering. Sponsored by IEEE, its members can attend lectures on the distinguished professor's research subject.
Professor Ye said, "We are at a time where the importance of AI in medical imaging is increasing.” He added, “I am proud to be appointed as a distinguished lecturer of the IEEE EMBS in recognition of my contributions to this field.”
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2020.02.27 View 8226 -
Professor Minsoo Rhu Recognized as Facebook Research Scholar
Professor Minsoo Rhu from the School of Electrical Engineering was selected as the recipient of the Systems for Machine Learning Research Awards presented by Facebook.
Facebook launched the award last year with the goal of funding impactful solutions in the areas of developer tookits, compilers and code generation, system architecture, memory technologies, and machine learning accelerator support.
A total of 167 scholars from 100 universities representing 26 countries submitted research proposals, and Facebook selected final 10 scholars. Professor Rhu made the list with his research topic ‘A Near-Memory Processing Architecture for Training Recommendation Systems.’ He will receive 5,000 USD in research funds at the award ceremony which will take place during this year’s AI Systems Faculty Summit at the Facebook headquarters in Menlo Park, California.
Professor Rhu’s submission was based on research on ‘Memory-Centric Deep Learning System Architecture’ that he carried out for three years under the auspices of Samsung Science and Technology Foundation from 2017. It was an academic-industrial cooperation research project in which leading domestic companies like Samsung Electronics and SK Hynix collaborated to make a foray into the global memory-centric smart system semiconductor market.
Professor Rhu who joined KAIST in 2018 has led various systems research projects to accelerate the AI computing technology while working at NVIDIA headquarters from 2014.
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2020.02.21 View 7889 -
Jeju Inspired Packaging by ID+IM Design Lab Wins 2020 iF Design Award
A water bottle designed by researchers from the ID+IM Design Laboratory led by Professor Sangmin Bae from the Department of Industrial Design won the packaging section of the 2020 iF Design Award.
The iF Design Award, hosted by the Hannover Exhibition Center in Germany, is one of the three major international design competitions. It receives more than 7,000 submissions from participants representing 60 countries.
The Jeju Yong-Am-Soo (which means ‘volcanic mineral water’ in English) bottle design was a product of an academic-industrial cooperation project carried out by Professor Bae’s team and a Korean confectionery company, Orion Corporation, to create a design for a premium mineral water bottle.
The motif of the awarded design was the beautiful nature of Jeju Island in Korea. The columnar joints and the horizon of Jeju Island were each represented by horizontal and vertical lines, completing a simple yet sensuous design.
The mystical volcanic Mount Halla printed on the transparent front-label of the bottle represents the daytime of Jeju Island, while the rear-label design, which is reflected through the transparent front-label, symbolizes the nighttime of Jeju Island. By putting the Orion constellation, a symbol of tourist’s guide, right above the Orion Corporation’s brand logo, Professor Bae’s team ambiently promotes the company’s identity.
Although the design uses a significantly smaller amount of materials than traditional water bottles, it can withstand about four times the pressure and weight. The efficient structure therefore shows excellence in both aesthetic and functional areas.
Professor Bae said, “I am happy with the fact that the result of this academic-industrial cooperation project became mass-produced through commercialization and was recognized by an international design award.” He continued, “Even though it was difficult for my team to come up with the design that fits both manufacturing and the distribution processes, we worked hard to achieve the structural and functional aspects, while also expressing beauty through its appearance.”
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2020.02.20 View 5863 -
New Graphene-Based Metasurface Capable of Independent Amplitude and Phase Control of Light
Researchers described a new strategy of designing metamolecules that incorporates two independently controllable subwavelength meta-atoms. This two-parametric control of the metamolecule secures the complete control of both amplitude and the phase of light.
A KAIST research team in collaboration with the University of Wisconsin-Madison theoretically suggested a graphene-based active metasurface capable of independent amplitude and phase control of mid-infrared light. This research gives a new insight into modulating the mid-infrared wavefront with high resolution by solving the problem of the independent control of light amplitude and phase, which has remained a long-standing challenge.
Light modulation technology is essential for developing future optical devices such as holography, high-resolution imaging, and optical communication systems. Liquid crystals and a microelectromechanical system (MEMS) have previously been utilized to modulate light. However, both methods suffer from significantly limited driving speeds and unit pixel sizes larger than the diffraction limit, which consequently prevent their integration into photonic systems.
The metasurface platform is considered a strong candidate for the next generation of light modulation technology. Metasurfaces have optical properties that natural materials cannot have, and can overcome the limitations of conventional optical systems, such as forming a high-resolution image beyond the diffraction limit. In particular, the active metasurface is regarded as a technology with a wide range of applications due to its tunable optical characteristics with an electrical signal.
However, the previous active metasurfaces suffered from the inevitable correlation between light amplitude control and phase control. This problem is caused by the modulation mechanism of conventional metasurfaces. Conventional metasurfaces have been designed such that a metaatom only has one resonance condition, but a single resonant design inherently lacks the degrees of freedom to independently control the amplitude and phase of light.
The research team made a metaunit by combining two independently controllable metaatoms, dramatically improving the modulation range of active metasurfaces. The proposed metasurface can control the amplitude and phase of the mid-infrared light independently with a resolution beyond the diffraction limit, thus allowing complete control of the optical wavefront.
The research team theoretically confirmed the performance of the proposed active metasurface and the possibility of wavefront shaping using this design method. Furthermore, they developed an analytical method that can approximate the optical properties of metasurfaces without complex electromagnetic simulations. This analytical platform proposes a more intuitive and comprehensively applicable metasurface design guideline.
The proposed technology is expected to enable accurate wavefront shaping with a much higher spatial resolution than existing wavefront shaping technologies, which will be applied to active optical systems such as mid-infrared holography, high-speed beam steering devices that can be applied for LiDAR, and variable focus infrared lenses.
Professor Min Seok Jang commented, "This study showed the independent control amplitude and phase of light, which has been a long-standing quest in light modulator technology. The development of optical devices using complex wavefront control is expected to become more active in the future."
MS candidate Sangjun Han and Dr. Seyoon Kim of the University of Wisconsin-Madison are the co-first authors of the research, which was published and selected as the front cover of the January 28 edition of ACS Nano titled “Complete complex amplitude modulation with electronically tunable graphene plasmonic metamolecules.”
This research was funded by the Samsung Research Funding & Incubation Center for Future Technology.
Publication:
Han et al. (2020) Complete Complex Amplitude Modulation with Electronically Tunable Graphene Plasmonic Metamolecules. ACS Nano, Vol. 14, Issue 1, pp. 1166-1175. Available online at https://doi.org/10.1021/acsnano.9b09277
Profile: Prof. Min Seok Jang, MS, PhD
jang.minseok@kaist.ac.kr
http://jlab.kaist.ac.kr/
Associate Professor
Jang Research Group
School of Electrical Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
Profile: Sangjun Han
sangjun.han@kaist.ac.kr
MS Candidate
School of Electrical Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
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2020.02.20 View 8070 -
New Catalyst Recycles Greenhouse Gases into Fuel and Hydrogen Gas
< Professor Cafer T. Yavuz (left), PhD Candidate Youngdong Song (center), and Researcher Sreerangappa Ramesh (right) >
Scientists have taken a major step toward a circular carbon economy by developing a long-lasting, economical catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas, and other chemicals. The results could be revolutionary in the effort to reverse global warming, according to the researchers. The study was published on February 14 in Science.
“We set out to develop an effective catalyst that can convert large amounts of the greenhouse gases carbon dioxide and methane without failure,” said Cafer T. Yavuz, paper author and associate professor of chemical and biomolecular engineering and of chemistry at KAIST.
The catalyst, made from inexpensive and abundant nickel, magnesium, and molybdenum, initiates and speeds up the rate of reaction that converts carbon dioxide and methane into hydrogen gas. It can work efficiently for more than a month.
This conversion is called ‘dry reforming’, where harmful gases, such as carbon dioxide, are processed to produce more useful chemicals that could be refined for use in fuel, plastics, or even pharmaceuticals. It is an effective process, but it previously required rare and expensive metals such as platinum and rhodium to induce a brief and inefficient chemical reaction.
Other researchers had previously proposed nickel as a more economical solution, but carbon byproducts would build up and the surface nanoparticles would bind together on the cheaper metal, fundamentally changing the composition and geometry of the catalyst and rendering it useless.
“The difficulty arises from the lack of control on scores of active sites over the bulky catalysts surfaces because any refinement procedures attempted also change the nature of the catalyst itself,” Yavuz said.
The researchers produced nickel-molybdenum nanoparticles under a reductive environment in the presence of a single crystalline magnesium oxide. As the ingredients were heated under reactive gas, the nanoparticles moved on the pristine crystal surface seeking anchoring points. The resulting activated catalyst sealed its own high-energy active sites and permanently fixed the location of the nanoparticles — meaning that the nickel-based catalyst will not have a carbon build up, nor will the surface particles bind to one another.
“It took us almost a year to understand the underlying mechanism,” said first author Youngdong Song, a graduate student in the Department of Chemical and Biomolecular Engineering at KAIST. “Once we studied all the chemical events in detail, we were shocked.”
The researchers dubbed the catalyst Nanocatalysts on Single Crystal Edges (NOSCE). The magnesium-oxide nanopowder comes from a finely structured form of magnesium oxide, where the molecules bind continuously to the edge. There are no breaks or defects in the surface, allowing for uniform and predictable reactions.
“Our study solves a number of challenges the catalyst community faces,” Yavuz said. “We believe the NOSCE mechanism will improve other inefficient catalytic reactions and provide even further savings of greenhouse gas emissions.”
This work was supported, in part, by the Saudi-Aramco-KAIST CO2 Management Center and the National Research Foundation of Korea.
Other contributors include Ercan Ozdemir, Sreerangappa Ramesh, Aldiar Adishev, and Saravanan Subramanian, all of whom are affiliated with the Graduate School of Energy, Environment, Water and Sustainability at KAIST; Aadesh Harale, Mohammed Albuali, Bandar Abdullah Fadhel, and Aqil Jamal, all of whom are with the Research and Development Center in Saudi Arabia; and Dohyun Moon and Sun Hee Choi, both of whom are with the Pohang Accelerator Laboratory in Korea. Ozdemir is also affiliated with the Institute of Nanotechnology at the Gebze Technical University in Turkey; Fadhel and Jamal are also affiliated with the Saudi-Armco-KAIST CO2 Management Center in Korea.
<Newly developed catalyst that recycles greenhouse gases into ingredients that can be used in fuel, hydrogen gas and other chemicals.>
Publication:
Song et al. (2020) Dry reforming of methane by stable Ni–Mo nanocatalysts on single-crystalline MgO. Science, Vol. 367, Issue 6479, pp. 777-781. Available online at http://dx.doi.org/10.1126/science.aav2412
Profile: Prof. Cafer T. Yavuz, MA, PhD
yavuz@kaist.ac.kr
http://yavuz.kaist.ac.kr/
Associate Professor
Oxide and Organic Nanomaterials for the Environment (ONE) Laboratory
Graduate School of Energy, Environment, Water and Sustainability (EEWS)
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
Profile: Youngdong Song ydsong88@kaist.ac.kr
Ph.D. Candidate
Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
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2020.02.17 View 15002 -
What Fuels a “Domino Effect” in Cancer Drug Resistance?
KAIST researchers have identified mechanisms that relay prior acquired resistance to the first-line chemotherapy to the second-line targeted therapy, fueling a “domino effect” in cancer drug resistance. Their study featured in the February 7 edition of Science Advances suggests a new strategy for improving the second-line setting of cancer treatment for patients who showed resistance to anti-cancer drugs.
Resistance to cancer drugs is often managed in the clinic by chemotherapy and targeted therapy. Unlike chemotherapy that works by repressing fast-proliferating cells, targeted therapy blocks a single oncogenic pathway to halt tumor growth. In many cases, targeted therapy is engaged as a maintenance therapy or employed in the second-line after front-line chemotherapy.
A team of researchers led by Professor Yoosik Kim from the Department of Chemical and Biomolecular Engineering and the KAIST Institute for Health Science and Technology (KIHST) has discovered an unexpected resistance signature that occurs between chemotherapy and targeted therapy. The team further identified a set of integrated mechanisms that promotes this kind of sequential therapy resistance.
“There have been multiple clinical accounts reflecting that targeted therapies tend to be least successful in patients who have exhausted all standard treatments,” said the first author of the paper Mark Borris D. Aldonza. He continued, “These accounts ignited our hypothesis that failed responses to some chemotherapies might speed up the evolution of resistance to other drugs, particularly those with specific targets.”
Aldonza and his colleagues extracted large amounts of drug-resistance information from the open-source database the Genomics of Drug Sensitivity in Cancer (GDSC), which contains thousands of drug response data entries from various human cancer cell lines. Their big data analysis revealed that cancer cell lines resistant to chemotherapies classified as anti-mitotic drugs (AMDs), toxins that inhibit overacting cell division, are also resistant to a class of targeted therapies called epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs).
In all of the cancer types analyzed, more than 84 percent of those resistant to AMDs, representatively ‘paclitaxel’, were also resistant to at least nine EGFR-TKIs. In lung, pancreatic, and breast cancers where paclitaxel is often used as a first-line, standard-of-care regimen, greater than 92 percent showed resistance to EGFR-TKIs. Professor Kim said, “It is surprising to see that such collateral resistance can occur specifically between two chemically different classes of drugs.”
To figure out how failed responses to paclitaxel leads to resistance to EGFR-TKIs, the team validated co-resistance signatures that they found in the database by generating and analyzing a subset of slow-doubling, paclitaxel-resistant cancer models called ‘persisters’.
The results demonstrated that paclitaxel-resistant cancers remodel their stress response by first becoming more stem cell-like, evolving the ability to self-renew to adapt to more stressful conditions like drug exposures. More surprisingly, when the researchers characterized the metabolic state of the cells, EGFR-TKI persisters derived from paclitaxel-resistant cancer cells showed high dependencies to energy-producing processes such as glycolysis and glutaminolysis.
“We found that, without an energy stimulus like glucose, these cells transform to becoming more senescent, a characteristic of cells that have arrested cell division. However, this senescence is controlled by stem cell factors, which the paclitaxel-resistant cancers use to escape from this arrested state given a favorable condition to re-grow,” said Aldonza.
Professor Kim explained, “Before this research, there was no reason to expect that acquiring the cancer stem cell phenotype that dramatically leads to a cascade of changes in cellular states affecting metabolism and cell death is linked with drug-specific sequential resistance between two classes of therapies.”
He added, “The expansion of our work to other working models of drug resistance in a much more clinically-relevant setting, perhaps in clinical trials, will take on increasing importance, as sequential treatment strategies will continue to be adapted to various forms of anti-cancer therapy regimens.”
This study was supported by the Basic Science Research Program of the National Research Foundation of Korea (NRF-2016R1C1B2009886), and the KAIST Future Systems Healthcare Project (KAISTHEALTHCARE42) funded by the Korean Ministry of Science and ICT (MSIT). Undergraduate student Aldonza participated in this research project and presented the findings as the lead author as part of the Undergraduate Research Participation (URP) Program at KAIST.
< Figure 1. Schematic overview of the study. >
< Figure 2. Big data analysis revealing co-resistance signatures between classes of anti-cancer drugs. >
Publication:
Aldonza et al. (2020) Prior acquired resistance to paclitaxel relays diverse EGFR-targeted therapy persistence mechanisms. Science Advances, Vol. 6, No. 6, eaav7416. Available online at http://dx.doi.org/10.1126/sciadv.aav7416
Profile: Prof. Yoosik Kim, MA, PhD
ysyoosik@kaist.ac.kr
https://qcbio.kaist.ac.kr/
Assistant Professor
Bio Network Analysis Laboratory
Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
Profile: Mark Borris D. Aldonza
borris@kaist.ac.kr
Undergraduate Student
Department of Biological Sciences
Korea Advanced Institute of Science and Technology (KAIST)
http://kaist.ac.kr
Daejeon, Republic of Korea
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2020.02.10 View 11633 -
Blood-Based Multiplexed Diagnostic Sensor Helps to Accurately Detect Alzheimer’s Disease
A research team at KAIST reported clinically accurate multiplexed electrical biosensor for detecting Alzheimer’s disease by measuring its core biomarkers using densely aligned carbon nanotubes.
Alzheimer’s disease is the most prevalent neurodegenerative disorder, affecting one in ten aged over 65 years. Early diagnosis can reduce the risk of suffering the disease by one-third, according to recent reports. However, its early diagnosis remains challenging due to the low accuracy but high cost of diagnosis.
Research team led by Professors Chan Beum Park and Steve Park described an ultrasensitive detection of multiple Alzheimer's disease core biomarker in human plasma. The team have designed the sensor array by employing a densely aligned single-walled carbon nanotube thin films as a transducer.
The representative biomarkers of Alzheimer's disease are beta-amyloid42, beta-amyloid40, total tau protein, phosphorylated tau protein and the concentrations of these biomarkers in human plasma are directly correlated with the pathology of Alzheimer’s disease.
The research team developed a highly sensitive resistive biosensor based on densely aligned carbon nanotubes fabricated by Langmuir-Blodgett method with a low manufacturing cost.
Aligned carbon nanotubes with high density minimizes the tube-to-tube junction resistance compared with randomly distributed carbon nanotubes, which leads to the improvement of sensor sensitivity. To be more specific, this resistive sensor with densely aligned carbon nanotubes exhibits a sensitivity over 100 times higher than that of conventional carbon nanotube-based biosensors.
By measuring the concentrations of four Alzheimer’s disease biomarkers simultaneously Alzheimer patients can be discriminated from health controls with an average sensitivity of 90.0%, a selectivity of 90.0% and an average accuracy of 88.6%.
This work, titled “Clinically accurate diagnosis of Alzheimer’s disease via multiplexed sensing of core biomarkers in human plasma”, were published in Nature Communications on January 8th 2020. The authors include PhD candidate Kayoung Kim and MS candidate Min-Ji Kim.
Professor Steve Park said, “This study was conducted on patients who are already confirmed with Alzheimer’s Disease. For further use in practical setting, it is necessary to test the patients with mild cognitive impairment.” He also emphasized that, “It is essential to establish a nationwide infrastructure, such as mild cognitive impairment cohort study and a dementia cohort study. This would enable the establishment of world-wide research network, and will help various private and public institutions.”
This research was supported by the Ministry of Science and ICT, Human Resource Bank of Chungnam National University Hospital and Chungbuk National University Hospital.
< A schematic diagram of a high-density aligned carbon nanotube-based resistive sensor that distinguishes patients with Alzheimer’s Disease by measuring the concentration of four biomarkers in the blood. >
Profile:
Professor Steve Park
stevepark@kaist.ac.kr
Department of Materials Science and Engineering
http://steveparklab.kaist.ac.kr/
KAIST
Profile:
Professor Chan Beum Park
parkcb at kaist.ac.kr
Department of Materials Science and Engineering
http://biomaterials.kaist.ac.kr/
KAIST
2020.02.07 View 8971 -
Cancer cell reversion may offer a new approach to colorectal cancer treatment
A novel approach to reverse the progression of healthy cells to malignant ones may offer a more effective way to eradicate colorectal cancer cells with far fewer side effects, according to a team of researchers based in South Korea.
Colorectal cancer, or cancer of the colon, is the third most common cancer in men and the second most common in women worldwide. South Korea has the second highest incident rate of colorectal cancer in the world, topped only by Hungary, according to the World Cancer Research Fund.
Their results were published as a featured cover article on January 2 in Molecular Cancer Research, a journal of the American Association for Cancer Research.
Led by Kwang-Hyun Cho, a professor and associate vice president of research at KAIST , the researchers used a computational framework to analyze healthy colon cells and colorectal cancer cells. They found that some master regulator proteins involved in cellular replication helped healthy colon cells mature, or differentiate into their specific cell type, and remain healthy. One particular protein, called SETDB1, suppressed the helpful proteins, forcing new cells to remain in a state of immaturity with the potential to become cancerous.
“This suggests that differentiated cells have an inherent resistance mechanism against malignant transformation and indicates that cellular reprogramming is indispensable for malignancy,” said Cho. “We speculated that malignant properties might be eradicated if the tissue-specific gene expression is reinstated — if we repress SETDB1 and allow the colon cells to mature and differentiate as they would normally.”
Image credit: Kwang-Hyun Cho, KAIST
Image restriction: News organizations may use or redistribute this image, with proper attribution, as part of news coverage of this paper only.
Using human-derived cells, Cho and his team targeted the tissue-specific gene expression programs identified in their computational analysis. These are the blueprints for the proteins that eventually help immature cells differentiate into tissue-specific cell types, such as colon cells. When a person has a genetic mutation, or has exposure to certain environmental factors, this process can go awry, leading to an overexpression of unhelpful proteins, such as SEDTB1.
The researchers specifically reduced the amount of SEDTB1 in these tissue-specific gene expression programs, which allowed the cells to mature and fully differentiate into colon cells.
“Our experiment also shows that SETDB1 depletion combined with cytotoxic drugs might be potentially beneficial to anticancer treatment,” Cho said. Cytotoxic drugs are often used for cancer treatment because the type of medicine contains chemicals that are toxic to cancer cells which can prevent them from replicating or growing. He noted that this combination could be more effective in treating cancer by transforming the cancer cell state into a less malignant or resistant state. He eventually pursues a cancer reversion therapy alone instead of conventional cytotoxic drug therapy since the cancer reversion therapy can provide a much less painful experience for patients with cancer who often have severe side effects from treatments intended to kill off cancerous cells, such as chemotherapy.
The researchers plan to continue studying how to return cancer cells to healthier states, with the ultimate goal of translating their work to therapeutic treatment for patients with colorectal cancer.
“I think our study of cancer reversion would eventually change the current medical practice of treating cancer toward the direction of keeping the patient’s quality of life while minimizing the side effects of current anti-cancer therapies,” Cho said.
###
This work was funded by KAIST and the National Research Foundation of Korea grants funded by the Korean government, the Ministry of Science and Information and Communication Technology.
Other authors include Soobeom Lee, Chae Young Hwang and Dongsan Kim, all of whom are affiliated with the Laboratory for Systems Biology and Bio-Inspired Engineering in the Department of Bio and Brain Engineering at KAIST; Chansu Lee and Sung Noh Hong, both with the Department of Medicine, and Seok-Hyung Kim of the Department of Pathology in the Samsung Medical Center at the Sungkyunkwan University School of Medicine.
-Profile
Professor Kwang-Hyun Cho
ckh@kaist.ac.kr
http://sbie.kaist.ac.kr/
Department of Bio and Brain Engineering
KAIST
https://www.kaist.ac.kr
2020.01.31 View 5851 -
KAIST Vaccine for Tick-Borne Disease ‘SFTS’ Protects Against Lethal Infection
A KAIST research team reported the development of a DNA vaccine for Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV) which completely protects against lethal infection in ferrets. The team confirmed that ferrets immunized with DNA vaccines encoding all SFTSV proteins showed 100% survival rate without detectable viremia and did not develop any clinical symptoms. This study was published in Nature Communications on August 23.
Severe Fever with Thrombocytopenia Syndrome (SFTS) is a newly emerging tick-borne infectious disease. The disease causes fever, severe thrombocytopenia, leukocytopenia as well as vomiting and diarrhea. Severe cases end up with organ system failure often accompanied by hemorrhages, and its mortality rate stands at 10–20%.
The viral disease has been endemic to East Asia but the spread of the tick vector to North America increases the likelihood of potential outbreak beyond the Far East Asia. The World Health Organization (WHO) has also put SFTSV into the priority pathogen requiring urgent attention category. Currently, no vaccine has been available to prevent SFTS.
The research team led by Professor Su-Hyung Park noted that DNA vaccines induce broader immunity to multiple antigens than traditional ones. Moreover, DNA vaccines stimulate both T cell and antibody immunity, which make them suitable for vaccine development.
They constructed DNA vaccines that encode full-length Gn, Gc, N, NS, and RNA polymerase genes based on common sequences of 31 SFTSV strains isolated from patients. Their vaccine candidates induced both neutralizing antibody response and multifunctional SFTSV-specific T cell response in mice and ferrets.
To investigate the vaccine’s efficacy in vivo, the research team applied a recently developed ferret model that recapitulates fatal clinical symptoms in SFTSV infection in humans. Vaccinated ferrets were completely protected from lethal SFTSV challenge without SFTSV detection in their blood, whereas all control ferrets died within 10 days’ post-infection.
The KAIST team found that anti-envelope antibodies play an important role in protective immunity, suggesting that envelope glycoproteins of SFTSV may be the most effective antigens for inducing protective immunity. Moreover, the study revealed that T cell responses specific to non-envelope proteins of SFTSV also can contribute to protection against SFTSV infection.
Professor Park said, “This is the first study demonstrating complete protection against lethal SFTSV challenge using an immunocompetent, middle-sized animal model with clinical manifestations of SFTSV infection. We believe this study provides valuable insights into designing preventive vaccines for SFTSV.”
2020.01.31 View 4648 -
Transformative Electronics Systems to Broaden Wearable Applications
Imagine a handheld electronic gadget that can soften and deform when attached to our skin. This will be the future of electronics we all dreamed of. A research team at KAIST says their new platform called 'Transformative Electronics Systems' will open a new class of electronics, allowing reconfigurable electronic interfaces to be optimized for a variety of applications.
A team working under Professor Jae-Woong Jeong from the School of Electrical Engineering at KAIST has invented a multifunctional electronic platform that can mechanically transform its shape, flexibility, and stretchability. This platform, which was reported in Science Advances, allows users to seamlessly and precisely tune its stiffness and shape.
"This new class of electronics will not only offer robust, convenient interfaces for use in both tabletop or handheld setups, but also allow seamless integration with the skin when applied onto our bodies," said Professor Jeong.
The transformative electronics consist of a special gallium metal structure, hermetically encapsulated and sealed within a soft silicone material, combined with electronics that are designed to be flexible and stretchable. The mechanical transformation of the electronic systems is specifically triggered by temperature change events controlled by the user.
"Gallium is an interesting key material. It is biocompatible, has high rigidity in solid form, and melts at a temperature comparable to the skin's temperature," said lead author Sang-Hyuk Byun, a researcher at KAIST.
Once the transformative electronic platform comes in contact with a human body, the gallium metal encapsulated inside the silicone changes to a liquid state and softens the whole electronic structure, making it stretchable, flexible, and wearable. The gallium metal then solidifies again once the structure is peeled off the skin, making the electronic circuits stiff and stable. When flexible electronic circuits were integrated onto these transformative platforms, it empowered them with the ability to become either flexible and stretchable or rigid.
"This technology could not have been achieved without interdisciplinary efforts," said co-lead author Joo Yong Sim, who is a researcher with ETRI. "We worked together with electrical, mechanical, and biomedical engineers, as well as material scientists and neuroscientists to make this breakthrough."
This universal electronics platform allowed researchers to demonstrate applications that were highly adaptable and customizable, such as a multi-purpose personal electronics with variable stiffness and stretchability, a pressure sensor with tuneable bandwidth and sensitivity, and a neural probe that softens upon implantation into brain tissue.
Applicable for both traditional and emerging electronics technologies, this breakthrough can potentially reshape the consumer electronics industry, especially in the biomedical and robotic domains. The researchers believe that with further development, this novel electronics technology can significantly impact the way we use electronics in our daily life.
< Transformative electronics in soft mode,which becomes wearable for outdoor applications.>
Video Material:
https://youtu.be/im0J18TfShk
Publication: Sang-Hyuk Byun, Joo Yong Sim, Zhanan Zhou, Juhyun Lee, Raza Qazi, Marie C. Walicki, Kyle E. Parker, Matthew P. Haney, Su Hwan Choi, Ahnsei Shon, Graydon B. Gereau, John Bilbily, Shuo Li, Yuhao Liu, Woon-Hong Yeo, Jordan G. McCall, Jianliang Xiao, and Jae-Woong Jeong. 2019. Mechanically transformative electronics, sensors, and implantable devices. Science Advances. Volume 5. No. 11. 12 pages. https://doi.org/10.1126/sciadv.aay0418
Link to download the full-text paper: https://advances.sciencemag.org/content/advances/5/11/eaay0418.full.pdf
Profile: Prof. Jae-Woong Jeong, PhD jjeong1@kaist.ac.kr
https://www.jeongresearch.org/
Professor
Bio-Integrated Electronics and Systems Laboratory
School of Electrical Engineering
Korea Advanced Institute of Science and Technology (KAIST) https://www.kaist.ac.kr
Daejeon 34141, Korea
Profile: Sang-Hyuk Byun, PhD Candidate
shbun95@kaist.ac.kr
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2020.01.31 View 6280 -
Professor Youngseok Ju Awarded the 13th ASAN Award for Young Medical Scientists
Professor Youngseok Ju from the Graduate School of Medical Science and Engineering was selected for the 13th ASAN Award for Young Medical Scientists under the age of 40. Professor Ju will receive 50 million won in prize money.
The ASAN Foundation established this Award in 2007 to encourage young medical scientists who accomplished outstanding achievements in basic and clinical medicine.
The winners are chosen based on a comprehensive assessment of consistency and originality, domestic and international impact, and contributions to medical development and fostering future generations.
Professor Ju is known for having identified the generation principle of cancer genome mutations. In particular, he is recognized for his contributions to the development of cancer prevention, diagnosis, and treatment, by having proven that some cases of lung cancer can occur from destructive changes in chromosomes in lung cells regardless of smoking.
The award ceremony will be held on March 19 in Seoul. The other award will be given to Professor Yong-Ho Lee from the Yonsei University College of Medicine.
2020.01.31 View 3626 -
Professor Sungyeol Choi Receives Science and ICT Ministerial Commendation
< Professor Sungyeol Choi >
Professor Sungyeol Choi from the Department of Nuclear and Quantum Engineering received the Science and ICT Ministerial Commendation on the 9th Annual Nuclear Safety and Promotion Day last month, in recognition of his contributions to the promotion of nuclear energy through the safe management of spent nuclear fuel and radioactive waste.
Professor Choi developed high-precision, multi-physics codes that can predict and prevent abnormal power fluctuations caused by boron hideout within nuclear fuel in a pressurized water reactor, solving the problem that has caused economic losses of tens of billions of won every year from industrial sites.
He is now developing a new technology that can reduce high-level waste by recycling spent nuclear fuel, while preventing nuclear material from being used for nuclear weapons, which is one of the biggest challenges faced by the nuclear industry.
In 2017, his first year in office as a KAIST professor, Professor Choi was selected as the youngest and the only member under 50 of the Standing Scientific Advisory Committee at the Information Exchange Meeting on Partitioning and Transmutation (IEMPT), an authoritative association on the disposal of high-level nuclear waste.
The following year, he became the first Korean to receive the Early Career Award, which is given to one person every two years by the International Youth Nuclear Congress.
2020.01.15 View 4675