KAIST

<(From Left) Hyun Bae Bang, Cheon Woo Moon, Cindy Pricilia Surya Prabowo, Minjung Ki, Sang Yup Lee, Changhee Cho, (Upper Left) Jae Sung Cho, Namjin Jang>

KAIST announced on May 19th that the KAIST-Hanwha Solutions Future Technology Research Institute, has secured bio-technology capable of mass-producing eco-friendly raw materials for plastics and textiles using waste resources, offering an alternative to petroleum-derived naphtha.

Naphtha, an essential feedstock for the petrochemical industry, has faced sharp price increases and supply instability in recent years, driving demand for sustainable alternatives. The new technology, addresses both resource supply stability and environmental concerns simultaneously.

A study led by Distinguished Professor Sang-yup Lee of the Department of Chemical and Biomolecular Engineering was published on May 12th in the journal Nature Chemical Engineering and has been selected as the cover paper for the May issue, a designation reserved for research achievements that represent the corresponding issue.

This platform uses ‘glycerol,’ a byproduct discarded during the biodiesel production process, as a raw material. The team engineered high-efficiency microorganisms to convert this waste into 1,3-propanediol (1,3-PDO), a key material for plastics and cosmetics, and optimized the fermentation process for industrial application. The research team succeeded in maintaining high production level even in a 300L pilot process, which serves as a test production stage before application in large-scale plant facilities, moving beyond the laboratory scale.

This study also used computer simulations to predict which genes to engineer, which resulted in improved production levels. The team also developed the fermentation system without antibiotic supplementation — a significant advance, as antibiotic use in industrial fermentation raises concerns about antimicrobial resistance and regulatory hurdles for food, cosmetic, and pharmaceutical applications.

< (AI Image) Microbial-based process for 1,3-propanediol (1,3-PDO) production >

The achievement reflects a 10-year partnership between KAIST and Hanwha Solutions that began in November 2015, with researchers from both sides working together directly on the experiments. Through the KAIST-Hanwha Solutions Future Technology Research Institute, the collaboration has produced 6 patent applications and 13 published papers, standing as a representative model of industry-academic cooperation in South Korea.

< Schematic diagram of microbial-based metabolic engineering strategies for 1,3-PDO production >

※ Paper Title: High-titer, antibiotic-free, pilot-scale production of 1,3-propanediol by engineered Corynebacterium, DOI: 10.1038/s44286-026-00389-w

※ Authors: Jae Sung Cho (KAIST, First Author), Cindy Pricilia Surya Prabowo (KAIST, First Author), Taehee Han (KAIST), Cheon Woo Moon (KAIST), Yoo-Sung Ko (KAIST), Changhee Cho (Hanwha Solutions), Je Woong Kim (KAIST), Won Jun Kim (Hanwha Solutions), Hyun Bae Bang (Hanwha Solutions), Jae Eun Lee (KAIST), Minjung Ki (KAIST), Namjin Jang (Hanwha Solutions), Sang Yup Lee (KAIST, Corresponding Author)

Jung-dae Kim, Head of the Research Institute at Hanwha Solutions, said, “This research is highly significant in that it confirmed the possibility of replacing existing petrochemical processes using bio-based raw materials. We expect it to be an important foundation for sustainable chemical material production and industrial application in the future.”

KAIST Distinguished Professor Sang Yup Lee of the Department of Chemical and Biomolecular Engineering stated, “This research is a case showing that microorganism-based chemical production can be sufficiently expanded to an actual industrial scale beyond the laboratory. It will contribute to producing various chemical materials in a more eco-friendly way in the future.”