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Professor Kwang-Hyun Cho publishes Encyclopaedia of Systems Biology
Professor Kwang-Hyun Cho KAIST Biological and Brain Engineering Department’s Professor Kwang-Hyun Cho edited the Encyclopaedia of Systems Biology with three scholars, all experts of Systems Biology in England, Germany and the United States. It is rare that a Korean scientist edits a world renowned academic science encyclopaedia. The Encyclopaedia, published by the New York office of Springer Verlag, was a grand international project five years in the making by 28 editors and 391 scientists with expertise in Systems Biology from around the world. The Encyclopaedia compiles various research areas of Systems Biology, the new academic paradigm of the 21st century through the integration of IT and BT, comprehensively on 3,000 pages in 4 four volumes. Professor Kwang-Hyun Cho, who led this international project, majored in electrical engineering and pioneered the field of Systems Biology, the integrated study of biological sciences and engineering, as a new integrated field of IT since the 1990s. The professor has achieved various innovative research results since then. Recently he has investigated “kernel,” an evolutionary core structure in complex biological networks and developed a new cancer treatment through the state space analysis of the molecular network of cancer cells. His work was published in Science Signalling, a sister journal of Science, as a cover story several times, and contributed to foundational research as well as commercialisation of the integrated fields of IT and BT.
Prof. Jong Chul Ye Appointed as the Editor of IEEE TIP
Professor Jong Chul Ye KAIST Bio & brain engineering department’s Professor Jong Chul Ye has been appointed as the editor of the "IEEE image processing transactions (IEEE TIP, IEEE Transaction on Image Processing)’, a prominent journal in the sector of imaging and medical image processing. Professor Ye will act as the editor in the field of medical imaging from February 2013 to January 2016, during which he will participate in examining thesis, establishing the direction of the journal and more. Professor Jong Chul Ye was recognized for his notable work in the field of medical imaging research using compressed sensing for the development of a high resolution medical image reconstruction techniques. This technique has pioneered a new area that is applicable in magnetic resonance imaging (MRI), computed tomography (CT), positron emission Camcorder (PET) and brain imaging. On the other hand, “IEEE TIP” was first published in 1992 and is currently the world’s leading authority in the field of image processing, medical imaging, image acquisition, compression and output.
Professor Cho Young-ho wins 'E2 Star' award
Professor Cho Young-ho from the Department of Bio and Brain Engineering at KAIST was chosen as the ‘E2 Star’ at the ‘2012 Engineering Education Festa’ in academics. The ‘2012 Engineering Education Festa’ hosted by the Ministry of Education, Science and Technology was held to display outstanding research results and to conceptualize the future of science education. The ‘E2 star’ award is given to renowned figures in industry, academia and society. A total of 35 candidates were recommended for the 3 fields and Professor Cho received the first place in the online voting. Professor Cho received high marks for his work in engineering education, research development and increasing the communication between academia and industry, as well as the commercialization of science and technology. Professor Cho was especially praised for the specialization of engineering education in integrated fields and the joint research with US and Swiss universities. Professor Cho Young-ho(Department of Bio and Brain Engineering, KAIST)
Using Light to Deliver Drugs to the Brain
The cerebral blood vessels have a unique blood-brain barrier. Using this unique structure, Professor Choi Chul Hee (Department of Bio-Brain Engineering) developed a technique to deliver drugs safely to the brain using lasers to alter the diffusivity of the blood-brain barrier. The blood-brain barrier allows the entry of only those drugs related to metabolic functions which made the entry of other drugs difficult. Due to this property it was difficult to administer the drug to a patient and have it affect the patient. Therefore the question was is it possible to maintain the effectiveness of the drug and allow it to pass through the barrier? The conventional method was to actually alter the structure of the drug or drill of small hole in the head and administering the drug directly, but these methods proved to be high risk and expensive. Professor Choi’s team used an ultra-short frequency laser beam on the barrier for 1/1000th of a second on the barrier to temporarily inhibit its function thereby allowing the drug to enter the brain safely.
Professor Young-Ho Cho elected as head of international academic conference
KAIST’s Professor Young-Ho Cho of the Department of Bio and Brain Engineering was appointed as the head of the PowerMems (Power Micro Electro Mechanical Systems) symposium to be held at Se-Jong Hotel in Seoul from November 15-18, 2011. Professor Jo is America’s first engineering doctor in the field of MEMS and is the founding member of the BSAC (Berkeley Sensor and Actuator Center), the start of the MEMS technology. PowerMEMS is the core of green growth and next generation energy production. It focuses on harvesting energy from minute vibrations or renewable energy sources such as sunlight or plants to harvest and store energy via micro or even nano size systems. The symposium was first held in 2000, and it is where leading experts in the field share papers on the production and harvesting energy in the micro scale.
Prof. Cho Elected Editor-in-Chief of Systems Biology
Prof. Kwang-Hyun Cho of Department of Bio and Brain Engineering at KAIST has been recently elected editor-in-chief of the Systems Biology, an international journal published by the London-based Institution of Engineering and Technology (IET), the university authorities said on Wednesday (Sept. 23) By the year 2012, Cho will oversee the editorial process of the journal covering intra- and inter-cellular dynamics, using systems- and signal-oriented approaches. IET, one of the world"s leading professional societies for the engineering and technology community, has a worldwide membership of more than 150,000. Prof. Cho"s research interests cover the areas of systems science with bio-medical applications including systems biology and bio-inspired engineering based on molecular systems biology. He is currently an editorial board member of Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007), Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007), and Bulletin of Mathematical Biology (Springer, New York, from 2008), and an editorial advisory board member of Molecular BioSystems (The Royal Society of Chemistry, U.K.).
Prof. Cho Appointed Editor-in-Chief of Systems Biology Encyclopedia
Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has been appointed as the editor-in-chief of the Encyclopedia of Systems Biology which is currently in development by Springer, a New York-based publishing company, university authorities said on Monday (July 6). Prof. Cho will share the position with three other eminent scholars from Britain, Germany and the United States. Cho will be responsible for selecting editorial members for each section of the Encyclopedia and overseeing the overall editorial process. The Encyclopedia of Systems Biology is a multi-volume reference compilation of the research outcomes in the field of systems biology all over the world. The ESB will consist of alphabetically ordered description of systems biology concepts and is envisaged to ultimately comprise 6-12 volumes. Publication of the Encyclopedia is scheduled for 2011.
Workshop on Biomedical IC to Be Held on March 26
KAIST will hold a workshop on "biomedical IC for future healthcare system" on March 26 at a lecture room of the School of Electrical Engineering & Computer Science. The workshop is organized by SEECS and the Korean Institute of Next Generation Computing. At the workshop, a variety of new technologies expected to expedite the development of biomedical systems will be presented. KAIST Prof. Hoi-Jun Yoo will speak on the "body channel communication" using the human body as the signal transmission medium and Dr. Seung-Hwan Kim of Electronics and Telecommunications Research Institute (ETRI) on a wearable vital sign monitoring system. Other subjects are CMOS (complementary metal-oxide semiconductor) fully electronic biosensor for biomolecular detection to be presented by KAIST Prof. Gyu-Hyeong Cho; nerve interface and IC (integrated circuit) system design by KAIST Prof. Yoon-gi Nam; design of neural recording and stimulation IC using time-varying magnetic field by KAIST Prof. Seong-Hwan Cho; low power multi-core digital signal processor for hearing aid by Dong-Wook Kim, senior researcher at the Samsung Advanced Institute of Technology; and a non-contact cardiac sensor by KAIST Prof. Seung-Chul Hong. With the advent of the ageing society, medical expenses of the elderly people are rapidly increasing. As a way to address the issue, interests are growing in "ubiquitous healthcare," a technology that uses a large number of environmental and patient sensors and actuators to monitor and improve patients’ physical and mental condition. The upcoming workshop is the first academic event on biomedical integrated chips to be held in Korea. The workshop will provide a valuable opportunity for experts in biomedical area to get together and examine the present status of Korean biomedical area and discuss about its future, KAIST officials said.
KAIST Wins First Prize at Recon Challenge of Int"l Magnetic Resonance Society
Professor Jong-chul Ye of the Department of Bio and Brain Engineering and Hong Jeong, a doctorate student, won the first prize at the Recon Challenge held as part of a workshop sponsored by the International Society for Magnetic Resonance in Medicine (ISMRM) held in Sedona, the United States. The workshop took place under the theme of “data sampling and image reconstruction” on Jan. 25-28 in Sedona, Arizona, the United States. The KAIST team beat out major magnetic resonance imaging groups from the U.S. and Europe. The Recon Challenge is a biennial competition highlighting different reconstruction strategies and metrics to compare them. ISMRM is an international, nonprofit, scientific association which promotes communication, research, development, and applications in the field of magnetic resonance in medicine and biology and other related topics. At the competition, the KAIST team presented a new dynamic MRI algorithm called k-t FOCUSS that is optimal from a compressed sensing perspective. The main contribution of the method is extension of k-t FOCUSS to a more general framework with prediction and residual encoding. The prediction provides an initial estimate while the residual encoding takes care of the remaining residual signals.
Prof. Cho Identifies Dynamics of Signal Transportation System in Control of Cell Proliferation
KAIST, Jan. 22, 2009 -- A research team led by Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, has identified a hidden mechanism of the dynamic behavior of signal transportation system involved in the control of cell proliferation, university authorities said. The finding is expected to provide a clue to appropriately controlling the pathway of ERK protein which is known to play a significant role in causing and spreading cancer. The research was featured as the cover paper of the latest online edition of the Journal of Cell Science. The Ras-Raf-MEK-ERK pathway (or ERK pathway) is an important signal transduction system involved in the control of cell proliferation, survival and differentiation. However, the dynamic regulation of the pathway by positive- and negative-feedback mechanism, in particular the functional role of Raf kinase inhibitor protein (RKIP) are still incompletely understood. RKIP is a physiological endogenous inhibitor of MEK phosphorylation by Raf kinases, but also participates in a positive-feedback loop in which ERK can inactivate RKIP. "We attempted to unearth the hidden dynamics of these feedback mechanisms and to identify the functional role of RKIP through combined efforts of biochemical experiments and computer simulations based on an experimentally validated mechanical model," Prof. Cho was quoted as saying.
KAIST Opens Cell Bench Research Center
KAIST opened a cell bench research center on the campus on Monday, Nov. 17, as a joint project with Samsung Electric Co. and Samsung Medical Center. On hand at the opening ceremony were about 100 persons from the three organizations, including KAIST President Nam-Pyo Suh, Samsung Electric"s Chief Technology Officer (CTO) Byung-Cheon Koh and Samsung Medical Center Vice President Hyo-Geun Lim. The newly-opened research center will be involved in the development of individually-tailored anti-cancer medicine using bio-inspired cell chips and technologies for clinical applications. Prof. Young-Ho Cho of the Department of Bio and Brain Engineering was named director of the research center. "Top-notch professionals from the electronic industry, academia and the medical community have gathered together to establish this research center. We expect the center will open a new path for the science and technology community and the industry to combine their strengths and develop innovative anti-cancer therapeutics," said KAIST President Nam-Pyo Suh at the opening ceremony. "The development of bio-cell chip technology represents a new challenge for the Samsung Electric which has focused on information technologies thus far. Through cooperation with KAIST and Samsung Medical Center, we expect to be able to develop a simple and efficient cure for cancer patients," commented Samsung Electric CTO Byung-Cheon Koh. The research center will be initially concentrating on the development of cell chips for lung cancer, one of the primary causes of death for Koreans.
KAIST Professor Named International Research Grant Reviewer
Prof. Kwang-Hyun Cho of the Department of Bio and Brain Engineering, KAIST, was appointed as a research grant review committee member of the international Human Frontier Science Program (HFSP) for 2008-2009, university authorities reported. The HFSP is a funding agency that supports international collaboration in interdisciplinary, basic research in the life sciences. It was initiated in 1989 by G7 countries as the sole funding program for international researches in neuroscience and molecular biology. The HFSP now has a membership of 35 countries and Korea joined the program in 2004. Prof. Cho will be responsible for reviewing grant applications in the field of systems biology. Prof. Cho received B.S., M.S. and Ph.D. degrees in electrical engineering from KAIST in 1993, 1995, and 1998, respectively. He has been working as a director of the KAIST Institute for the BioCentury and KAIST"s Laboratory for Systems Biology and Bio-Inspired Engineering. He has been serving on editorial advisory boards of various international science journals, including Systems and Synthetic Biology (Springer, Netherlands, from 2006), BMC Systems Biology (BMC, London, U.K., from 2007) and Gene Regulation and Systems Biology (Libertas Academica, New Zealand, from 2007). He is a senior member of the Engineering in Medicine and Biology Society (EMBS) affiliated with the Institute of Electronics and Electrical Engineers (IEEE). His research interests cover the areas of systems science with bio-medical applications, especially systems biology and bio-inspired engineering based on molecular systems biology.
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