Nature+Communications
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How to Trigger Innate Fear Response?
(Figure:This illustration describes how ACC-BLA circuit controls innate freezing response depending on its activity level.)
When animals encounter danger, they usually respond to the situation in one of two ways: to freeze or to flee. How do they make this quick decision in a life or death moment?
According to KAIST neuroscientists, there are two types of fear: learned versus innate. The latter is known to be induced without any prior experience and is thus naturally encoded in the brain. A research team under Professor Jin-Hee Han in the Department of Biological Sciences identified the brain circuit responsible for regulating the innate fear response.
The study, which appeared in the July 24 issue of Nature Communications represents a significant step toward understanding how the neural circuits in the prefrontal cortex create behavioral responses to external threats. This also represents a new paradigm in therapeutic development for fear-related mental disorders.
Responses of freezing or fleeing when facing external threats reflect behavioral and physiological changes in an instinctive move to adapt to the new environment for survival. These responses are controlled by the emotional circuit systems of the brain and the malfunction of this circuit leads to fear-related disorders.
The anterior cingulate cortex (ACC) is a sub-region within the prefrontal cortex, comprising a part of the brain circuitry that regulates behavioral and physiological fear responses. This area is capable of high-order processing of the perceived sensory information and conveys ‘top-down’ information toward the amygdala and brainstem areas, known as the response outlet.
Many studies have already demonstrated that the brain regions in the prefrontal cortex regulate the response against learned threats. However, it has been unknown how innate responses against fear are encoded in the neural circuits in the prefrontal cortex.
Dr. Jinho Jhang, the lead author of the study explains how the team achieved their key idea. “Many overseas studies have already proved that the prefrontal cortex circuit works to regulate the fear response. However, researchers have paid little attention to the innate response against predators. Professor Han suggested we do research on the instinctive fear response instead of the learned response. We particularly focused on the anterior cingulate region, which has been connected with memory, pain, and sympathy, but not the fear response itself. Since we turned in this new direction, we have accumulated some significant data,” said Dr. Jhang.
For this study, Professor Han’s team investigated how mice react when exposed to the olfactory stimuli of predators. Based on the results of optogenetic manipulation, neural circuit tracing, and ex vivo slice electrophysiology experiments, the team demonstrated that the anterior cingulate cortex and its projection input to the basolateral amygdala play a role in the inhibitory regulation of innate fear responses to predators’ odors in mice.
Professor Han believes these results will extend the understanding of how instinctive fear responses can be encoded in our brain circuits. “Our findings will help to develop therapeutic treatments for mental disorders aroused from fear such as panic disorders and post-traumatic stress disorder,” said Professor Han.
2018.08.08 View 7286 -
New Quantum Mechanical States Observed
(Professor Han (far right) and his research team)
A KAIST research team observed a new quantum mechanical magnetic state ‘Jeff = 3/2.’ This first observation of ‘Jeff=3/2’ could be the foundation for future research on superconductivity and quantum magnetism.
In quantum mechanics, total angular momentum is defined as the sum of spin and orbital angular momenta and is denoted with the ‘J.’ The newly identified magnetic moment can be described as a kind of angular momentum that occurs when specific conditions are met and has been denoted ‘Jeff’ with the meaning ‘effective angular momentum’ in the field. Jeff=3/2 has been a topic of discussion but was yet to be observed.
The research was co-led by Professor Myung Joon Han of the Department of Physics at Chung-Ang University in Korea, RIKEN in Japan, and the Argonne National Laboratory in the US. This research was published in Nature Communications on October 14, 2017.
In academia, spin-orbital coupling was known to lead to a unique quantum state and has been an active area of recent research. In contrast to magnetic moment by electron spin and orbital, the effective magnetic moment Jeff, formed from the coupling of the two, shows a unique ground state and interaction patterns, which could lead to new phenomena and properties.
Most studies in the last decade focused on ‘Jeff=1/2’, but there has not been any observation of ‘Jeff=3/2’, which led to slow progress. In 2014, the research team led by Prof. Han theoretically predicted the possibility of the ‘Jeff=3/2’ state in a certain type of materials based on molecular orbital, instead of atomic orbital. In the current study, the team applied the Selection Rule of quantum mechanics for the ‘Jeff=3/2’ state, which differs to the general spin moment, in order to experimentally detect this moment.
When electrons near the atomic nucleus are excited by X-rays, the excited electrons can be absorbed or re-emitted through interactions with other electrons. Here, the Selection Rule is applied to electrons. According to quantum mechanics, this rule is very unique in the ‘Jeff=3/2’ state and ‘Jeff=3/2’ is predicted to be distinguishable from general spin states. The prediction that was made using this idea was verified through the experiment using electrons extracted from tantalum at two different energy levels. In this material, the unique quantum mechanical interference by the ‘Jeff=3/2’ moment can be taken as direct evidence for its existence.
The new quantum state is very unique from any of the previously known magnetic states and this study could be the starting point for future research on the ‘Jeff=3/2’ moment. Further, this finding could contribute to future research on various properties of the magnetic states and its interactions.
(Figure 1: Crystal structure, MO levels, and RIXS process in GaTa4Se8.)
(Figure 2: Cluster model calculations of the L3 and L2 RIXS spectra)
2017.12.14 View 5328